Resuscitation-inducing and intelligence-improving pill as well as preparation method and application thereof

Abstract

The invention discloses a resuscitation and intelligence development pill and a preparation method and application thereof, and relates to the technical field of traditional Chinese medicine, the resuscitation and intelligence development pill comprises a traditional Chinese medicine composition and auxiliary materials, and the traditional Chinese medicine composition is prepared from the following components in parts by weight: 10-40 parts of polygala tenuifolia (without cores), 8-20 parts of fructus alpiniae oxyphyllae, 15-35 parts of rhizoma acori graminei (without hair), 10-50 parts of ginseng and 10-25 parts of poria with hostwood (without veneers). , 8-15 parts of morinda officinalis (without cores), 10-25 parts of semen cuscutae, 15-30 parts of cortex lycii radicis and the like. The traditional Chinese medicine composition provided by the invention has the effects of inducing resuscitation, promoting intelligence, enhancing memory and the like, and animal experiments show that the resuscitation-promoting and intelligence-promoting pill provided by the invention can remarkably improve the spatial learning and memory ability of LPS-induced learning and memory impairment mice, shorten the escape latency of the mice in a positioned navigation experiment, and improve the learning and memory impairment of the mice. And a new treatment means is provided for improving memory and cognitive function decline symptoms.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a pill for improving the resuscitation and improving intelligence, and a preparation method and application thereof. Background Art

[0002] In the field of traditional Chinese medicine technology, drugs that can improve intelligence and memory have always attracted much attention. With the accelerated pace of modern life and the increase in work pressure, more and more people are experiencing problems such as memory loss and cognitive decline, which not only affects daily life and work efficiency, but may also have a negative impact on personal mental health. Therefore, the development of traditional Chinese medicine preparations with the effects of improving intelligence and memory is of great practical significance.

[0003] In traditional Chinese medicine, there are many herbs that are believed to have the effects of improving intelligence, calming the nerves, and nourishing the brain, such as Polygala tenuifolia, Alpinia oxyphylla, Acorus calamus, and Ginseng. In traditional Chinese medicine theory, these herbs each have their own unique medicinal properties and meridians, and through reasonable compatibility, they can play a synergistic and synergistic role. However, most of the existing Chinese medicine preparations for improving intelligence have problems such as unstable efficacy, which limits their wide clinical application.

[0004] Especially for the treatment of learning and memory impairment, the existing drug options are relatively limited, and some drugs have side effects. Therefore, the development of a safe, effective, and easy-to-prepare Chinese medicine preparation for improving intelligence has become a hot topic in the field of Chinese medicine research. Summary of the invention

[0005] In order to solve the above problems, the present invention provides a pill for improving resuscitation and improving intelligence, and a preparation method and application thereof.

[0006] In a first aspect, the present invention provides a pill for improving one's ability to awaken others and improve one's intelligence. The pill for improving one's ability to awaken others and improve one's intelligence comprises a traditional Chinese medicine composition and excipients. The traditional Chinese medicine composition is prepared from the following components in parts by weight:

[0007] 10-40 parts of Polygala (core removed), 8-20 parts of Alpinia oxyphylla, 15-35 parts of Acorus calamus (hair removed), 10-50 parts of Ginseng, 10-25 parts of Poria (wood bark removed), 8-15 parts of Morinda officinalis (core removed), 10-25 parts of Cuscuta seeds, 15-30 parts of Lycium bark, 8-15 parts of Polygonum multiflorum (processed), 12-20 parts of Salvia miltiorrhiza, 12-20 parts of Ziziphus jujuba seeds (fried), 8-15 parts of roasted tortoise shell, 8-15 parts of pearl, 15-20 parts of longan pulp, 12-20 parts of raw oyster, 12-20 parts of chicken's gizzard lining, 10-15 parts of chrysanthemum, 10-15 parts of atractylodes, 15-20 parts of astragalus, 6-8 parts of roasted liquorice, 8-15 parts of cyperus rotundus, 8-15 parts of curcuma, 10-15 parts of schisandra chinensis, 10-15 parts of raw rehmannia and 12-15 parts of chuanxiong.

[0008] Furthermore, the Chinese medicine composition is prepared from the following components in parts by weight:

[0009] 34.7 parts of Polygala tenuifolia (with heart removed), 11.5 parts of Alpinia oxyphylla, 20.1 parts of Acorus tatarinowii (with hairs removed), 15.8 parts of Ginseng, 13.9 parts of Poria (with root bark removed), 10.3 parts of Morinda officinalis (with heart removed), 16.5 parts of Cuscuta chinensis, 20.6 parts of Lycium chinense Mill., 9.9 parts of Polygonum multiflorum (processed), 15.1 parts of Salvia miltiorrhiza, 16.2 parts of Ziziphus jujuba Mill. var. spinosa (Huex) H. F. Chow (fried), 11.3 parts of Tortoise Plastron (prepared), 10.0 parts of Margarita, 17.4 parts of Longan Aril, 15.0 parts of Oyster Shell, 16.9 parts of Endothelium Corneum Gigeriae Galli, 13.5 parts of Chrysanthemum morifolium Ramat., 12.8 parts of Atractylodes macrocephala Koidz., 16.6 parts of Astragalus membranaceus (Fisch.) Bunge, 7.0 parts of Glycyrrhiza uralensis Fisch. (prepared), 10.5 parts of Cyperus rotundus L., 12.4 parts of Curcuma aromatica Salisb., 13.0 parts of Schisandra chinensis (Turcz.) Baill., 12.5 parts of Rehmannia glutinosa Libosch. and 13.0 parts of Ligusticum wallichii Franch.

[0010] Further, the adjuvant includes honey, and the weight ratio of the traditional Chinese medicine composition to the adjuvant is 1:(1.3 - 1.7).

[0011] In a second aspect, based on the same inventive concept, the present invention provides a preparation method of the resuscitation and intelligence - enhancing pill according to any one of the first aspect, as Figure 1 shown, the preparation method of the resuscitation and intelligence - enhancing pill includes the following steps:

[0012] Crush and sieve the traditional Chinese medicine composition to obtain a first fine powder of medicinal materials with a particle size of 100 - 200 meshes;

[0013] Place the first fine powder of medicinal materials in the cavity of a low - temperature plasma treatment device for low - temperature plasma treatment, and then spray a trehalose solution to obtain a second fine powder of medicinal materials;

[0014] Add the second fine powder of medicinal materials and a complex enzyme to a solvent for gradient heating extraction, then filter and concentrate and dry the obtained extract to obtain the traditional Chinese medicine composition;

[0015] Mix the traditional Chinese medicine composition and the adjuvant, then make pills and dry to obtain the resuscitation and intelligence - enhancing pill.

[0016] Further, the working condition parameters of the low - temperature plasma treatment include: using a mixed gas composed of argon and oxygen with a volume ratio of 9:1 as the working medium, a discharge power of 240 - 330 W, and a treatment time of 60 - 120 seconds.

[0017] Further, the weight ratio of the second fine powder of medicinal materials, the complex enzyme and the solvent is 1:(0.005 - 0.01):(8 - 12); the complex enzyme is composed of cellulase and pectinase with a weight ratio of (2 - 5):1.

[0018] Further, the solvent is obtained by mixing ethanol aqueous solution with a volume percentage of 40-50% and adding 0.1-0.2% (by weight of the solvent) of Tween 80.

[0019] Further, the steps of gradient heating extraction include the following process:

[0020] The first stage: Stir at a temperature of 25-35°C for 30-60 minutes;

[0021] The second stage: Stir at a temperature of 80-85°C for 90-120 minutes.

[0022] Further, when honey is used as an adjuvant, the steps of mixing the traditional Chinese medicine composition and the adjuvant, followed by pill making and drying to obtain the resuscitating and intelligence-enhancing pills include the following process:

[0023] Heat the honey at 110-115°C for 10-15 minutes for refining, and then add the traditional Chinese medicine composition under continuous stirring to obtain a honey medicine mass;

[0024] Add the honey medicine mass into a pill making machine to make pills, and then dry to obtain the resuscitating and intelligence-enhancing pills.

[0025] In a third aspect, based on the same inventive concept, the present invention provides an application of the resuscitating and intelligence-enhancing pills according to any one of the first aspect or the resuscitating and intelligence-enhancing pills prepared by the preparation method according to any one of the second aspect in the preparation of products for improving memory and cognitive function decline symptoms.

[0026] The above technical solutions provided by the embodiments of the present invention have at least the following advantages compared with the prior art:

[0027] The embodiments of the present invention provide a resuscitating and intelligence-enhancing pill, its preparation method and application. The traditional Chinese medicine composition provided by the present invention has the effects of resuscitating the mind and enhancing intelligence. Animal experiments show that the resuscitating and intelligence-enhancing pills provided by the present invention can significantly improve the spatial learning and memory ability of mice with learning and memory impairment induced by LPS, and shorten the escape latency of mice in the positioning navigation experiment, providing a new treatment means for improving memory and cognitive function decline symptoms. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The accompanying drawings here are incorporated into the specification and form a part of this specification, showing embodiments consistent with the present invention, and are used together with the specification to explain the principles of the present invention.

[0029] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0030] Figure 1 It is a schematic flow chart of a preparation method of a resuscitating and intelligence-enhancing pill provided by an embodiment of the present invention. Specific embodiments

[0031] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0032] Unless otherwise specifically stated, all kinds of raw materials, reagents, instruments, and equipment used in the present invention can be obtained through market purchases or can be prepared by existing methods.

[0033] In a first aspect, the present invention provides a resuscitating and intelligence-enhancing pill, and the resuscitating and intelligence-enhancing pill includes a traditional Chinese medicine composition and excipients. By weight parts, the traditional Chinese medicine composition is prepared from the following components:

[0034] Polygala tenuifolia (with the heart removed) 10 - 40 parts, Alpinia oxyphylla 8 - 20 parts, Acorus tatarinowii (with the hair removed) 15 - 35 parts, Ginseng 10 - 50 parts, Poria (with the woody bark removed) 10 - 25 parts, Morinda officinalis (with the heart removed) 8 - 15 parts, Cuscuta chinensis 10 - 25 parts, Lycium chinense Mill. 15 - 30 parts, Polygonum multiflorum Thunb. (processed) 8 - 15 parts, Salvia miltiorrhiza 12 - 20 parts, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chow (fried) 12 - 20 parts, Testudinis carapax et plastrum preparata 8 - 15 parts, Margarita 8 - 15 parts, Arillus longan 15 - 20 parts, Concha Ostreae 12 - 20 parts, Endothelium Corneum Gigeriae Galli 12 - 20 parts, Flos Chrysanthemi 10 - 15 parts, Atractylodes macrocephala Koidz. 10 - 15 parts, Astragalus membranaceus (Fisch.) Bunge 15 - 20 parts, Glycyrrhiza uralensis Fisch. preparata 6 - 8 parts, Cyperus rotundus L. 8 - 15 parts, Curcuma aromatica Salisb. 8 - 15 parts, Schisandra chinensis (Turcz.) Baill. 10 - 15 parts, Rehmannia glutinosa Libosch. 10 - 15 parts, and Ligusticum wallichii Franch. 12 - 15 parts.

[0035] The embodiments of the present invention provide a resuscitating and intelligence-enhancing pill. The traditional Chinese medicine composition provided by the present invention has the effects of resuscitating the mind and enhancing memory. Animal experiments show that the resuscitating and intelligence-enhancing pill provided by the present invention can significantly improve the spatial learning and memory ability of mice with learning and memory impairment induced by LPS, and shorten the escape latency of mice in the place navigation experiment, providing a new treatment means for improving memory and cognitive function decline symptoms.

[0036] In some specific embodiments, the traditional Chinese medicine composition is prepared from the following components by weight parts:

[0037] Polygala tenuifolia (with heart removed) 34.7 parts, Alpinia oxyphylla 11.5 parts, Acorus tatarinowii (with hairs removed) 20.1 parts, Panax ginseng 15.8 parts, Poria cocos (with root bark removed) 13.9 parts, Morinda officinalis (with heart removed) 10.3 parts, Cuscuta chinensis 16.5 parts, Lycium chinense 20.6 parts, Polygonum multiflorum (processed) 9.9 parts, Salvia miltiorrhiza 15.1 parts, Ziziphus jujuba var. spinosa (fried) 16.2 parts, Tortoise plastron (processed with honey) 11.3 parts, Margarita 10.0 parts, Arillus longan 17.4 parts, Ostrea gigas 15.0 parts, Endothelium corneum gigeriae galli 16.9 parts, Chrysanthemi flos 13.5 parts, Atractylodes macrocephala 12.8 parts, Astragalus membranaceus 16.6 parts, Glycyrrhiza uralensis (processed with honey) 7.0 parts, Cyperus rotundus 10.5 parts, Curcuma aromatica 12.4 parts, Schisandra chinensis 13.0 parts, Rehmannia glutinosa 12.5 parts, and Ligusticum wallichii 13.0 parts.

[0038] In some specific embodiments, the adjuvant includes honey, and the weight ratio of the traditional Chinese medicine composition to the adjuvant is 1:(1.3 - 1.7).

[0039] In a second aspect, based on the same inventive concept, the present invention provides a preparation method of the resuscitation and intelligence - enhancing pill according to any one of the first aspect, as Figure 1 shown, the preparation method of the resuscitation and intelligence - enhancing pill includes the following steps:

[0040] Crush and sieve the traditional Chinese medicine composition to obtain a first fine powder of medicinal materials with a particle size of 100 - 200 mesh;

[0041] Place the first fine powder of medicinal materials in the cavity of a low - temperature plasma treatment device for low - temperature plasma treatment, and then spray a trehalose solution to obtain a second fine powder of medicinal materials;

[0042] Add the second fine powder of medicinal materials and a complex enzyme to a solvent for gradient heating extraction, then filter and concentrate and dry the obtained extract to obtain the traditional Chinese medicine composition;

[0043] Mix the traditional Chinese medicine composition and the adjuvant, and then make pills and dry them to obtain the resuscitation and intelligence - enhancing pill.

[0044] The preparation method of the resuscitation and intelligence - enhancing pill provided by the embodiments of the present invention has simple operation, does not require additional specific equipment, and is suitable for industrial mass production.

[0045] In some specific embodiments, the working condition parameters of the low - temperature plasma treatment include: using a mixed gas composed of argon and oxygen with a volume ratio of 9:1 as the working medium, a discharge power of 240 - 330 W, and a treatment time of 60 - 120 seconds.

[0046] In some specific embodiments, the weight ratio of the second medicinal material fine powder, the composite enzyme, and the solvent is 1:(0.005 - 0.01):(8 - 12); the composite enzyme is composed of cellulase and pectinase with a weight ratio of (2 - 5):1.

[0047] In some specific embodiments, the solvent is obtained by compounding ethanol aqueous solution with a volume percentage of 40 - 50% and adding 0.1 - 0.2% (by weight of the solvent) of Tween 80.

[0048] In some specific embodiments, the steps of gradient heating extraction include the following process:

[0049] The first stage: Stir at a temperature of 25 - 35°C for 30 - 60 minutes;

[0050] The second stage: Stir at a temperature of 80 - 85°C for 90 - 120 minutes.

[0051] In some specific embodiments, when using honey as an adjuvant, the steps of mixing the traditional Chinese medicine composition and the adjuvant, followed by pill making and drying to obtain the resuscitation and intelligence - enhancing pills include the following process:

[0052] Heat the honey at 110 - 115°C for 10 - 15 minutes for refining honey, and then add the traditional Chinese medicine composition under continuous stirring to obtain a honey - medicine mass;

[0053] Add the honey - medicine mass into a pill - making machine for pill making, and then dry to obtain the resuscitation and intelligence - enhancing pills.

[0054] In a third aspect, based on the same inventive concept, the present invention provides an application of the resuscitation and intelligence - enhancing pills according to any one of the first aspect or the resuscitation and intelligence - enhancing pills prepared by the preparation method according to any one of the second aspect in the preparation of products for improving memory and cognitive function decline symptoms.

[0055] It should be noted that for the component raw materials involved in the resuscitation and intelligence - enhancing pills, their preparation methods, and applications provided in the embodiments of the present invention, without special limitations or specific descriptions, commercially available products can be directly used, or they can be self - made by using existing publicly disclosed preparation methods; meanwhile, for the steps and parameters involved, without special limitations or specific descriptions, they can be carried out according to the steps and parameters of traditional Chinese medicine preparation processes disclosed in the prior art or directly used according to the operation manuals of existing equipment, and the present invention document will not elaborate one by one.

[0056] The present invention will be further described below in conjunction with specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and not to limit the scope of the present invention. The experimental methods without specific conditions in the following embodiments are usually determined according to national standards. If there is no corresponding national standard, they are carried out according to general international standards, conventional conditions, or conditions recommended by the manufacturer.

[0057] Example 1

[0058] This example provides a Kaiqiao Yizhi Pills, the Kaiqiao Yizhi Pills comprising a traditional Chinese medicine composition and an adjuvant, the adjuvant being honey, and the weight ratio of the traditional Chinese medicine composition to the adjuvant being 1:1.5; calculated by weight parts, the traditional Chinese medicine composition is prepared from the following components:

[0059] Radix Polygalae (with heart removed) 34.7 parts, Fructus Alpiniae Oxyphyllae 11.5 parts, Rhizoma Acori Tatarinowii (with hair removed) 20.1 parts, Radix Ginseng 15.8 parts, Poria (with bark removed) 13.9 parts, Radix Morindae Officinalis (with heart removed) 10.3 parts, Semen Cuscutae 16.5 parts, Cortex Lycii Radicis 20.6 parts, Radix Polygoni Multiflori Praeparata 9.9 parts, Radix Salviae Miltiorrhizae 15.1 parts, Semen Ziziphi Spinosae (fried) 16.2 parts, Carapax Testudinis Praeparatus 11.3 parts, Margarita 10.0 parts, Arillus Longan 17.4 parts, Concha Ostreae 15.0 parts, Endothelium Corneum Gigeriae Galli 16.9 parts, Flos Chrysanthemi 13.5 parts, Rhizoma Atractylodis Macrocephalae 12.8 parts, Radix Astragali 16.6 parts, Radix Glycyrrhizae Praeparata 7.0 parts, Rhizoma Cyperi 10.5 parts, Radix Curcumae 12.4 parts, Fructus Schisandrae Chinensis 13.0 parts, Radix Rehmanniae 12.5 parts and Rhizoma Chuanxiong 13.0 parts.

[0060] The preparation method of the above-mentioned Kaiqiao Yizhi Pills comprises the following steps:

[0061] Crush and sieve the traditional Chinese medicine composition to obtain a first fine powder of medicinal materials with a particle size of 150 mesh;

[0062] Place the first fine powder of medicinal materials in the cavity of a low-temperature plasma treatment device for low-temperature plasma treatment, and then spray a trehalose solution with a concentration of 0.5 g / mL, and the spraying amount accounts for 20 wt% of the first fine powder of medicinal materials to obtain a second fine powder of medicinal materials; wherein, the working condition parameters of the low-temperature plasma treatment include: using a mixed gas composed of argon and oxygen with a volume ratio of 9:1 as the working medium, the discharge power is 285 W, and the treatment time is 90 seconds;

[0063] Add the fine powder of the second medicinal material and the complex enzyme to a solvent for gradient heating extraction, then filter and concentrate and dry the obtained extract to obtain the traditional Chinese medicine composition; wherein, the weight ratio of the fine powder of the second medicinal material, the complex enzyme and the solvent is 1:0.008:11; the complex enzyme is composed of cellulase and pectinase with a weight ratio of 4:1; the solvent is obtained by compounding 0.2% Tween 80 by weight percentage into an ethanol aqueous solution with a volume percentage of 45%; the steps of gradient heating extraction include the following processes: the first stage: stir at 30°C for 45 minutes; the second stage: stir at 82°C for 100 minutes.

[0064] Heat the honey at 112°C for 13 minutes for refining honey, and then add the traditional Chinese medicine composition under continuous stirring to obtain a honey medicine mass; add the honey medicine mass into a pill making machine for pill making, and then dry to obtain the resuscitation and intelligence - promoting pill.

[0065] Example 2

[0066] This example provides a resuscitation and intelligence - promoting pill and its preparation method. The difference from Example 1 is only that: calculated by weight parts, the traditional Chinese medicine composition is prepared from the following components: polygala tenuifolia (with heart removed) 10 parts, semen carthami 8 parts, acorus tatarinowii (with hair removed) 15 parts, ginseng 10 parts, poria cocos (with woody bark removed) 10 parts, morinda officinalis (with heart removed) 8 parts, cuscuta chinensis 10 parts, cortex lycii radicis 15 parts, polygonum multiflorum (processed) 8 parts, salvia miltiorrhiza 12 parts, semen ziziphi spinosae (fried) 12 parts, tortoise plastron (prepared) 8 parts, pearl 8 parts, longan aril 15 parts, oyster 12 parts, endoconcha seu carapax galli 12 parts, flos chrysanthemi 10 parts, atractylodes macrocephala 10 parts, astragalus membranaceus 15 parts, roasted licorice root 6 parts, cyperus rotundus 8 parts, curcuma aromatica 8 parts, schizandra chinensis 10 parts, rehmannia glutinosa 10 parts, and ligusticum wallichii 12 parts.

[0067] Example 3

[0068] This example provides a resuscitation and intelligence - promoting pill and its preparation method. The difference from Example 1 is only that: calculated by weight parts, the traditional Chinese medicine composition is prepared from the following components: polygala tenuifolia (with heart removed) 40 parts, semen carthami 20 parts, acorus tatarinowii (with hair removed) 35 parts, ginseng 50 parts, poria cocos (with woody bark removed) 25 parts, morinda officinalis (with heart removed) 15 parts, cuscuta chinensis 25 parts, cortex lycii radicis 30 parts, polygonum multiflorum (processed) 15 parts, salvia miltiorrhiza 20 parts, semen ziziphi spinosae (fried) 20 parts, tortoise plastron (prepared) 15 parts, pearl 15 parts, longan aril 20 parts, oyster 20 parts, endoconcha seu carapax galli 20 parts, flos chrysanthemi 15 parts, atractylodes macrocephala 15 parts, astragalus membranaceus 20 parts, roasted licorice root 8 parts, cyperus rotundus 15 parts, curcuma aromatica 15 parts, schizandra chinensis 15 parts, rehmannia glutinosa 15 parts, and ligusticum wallichii 15 parts.

[0069] Comparative Example 1

[0070] This example provides an Acupuncture and Resuscitation Intelligence - Boosting Pill and its preparation method. The difference from Example 1 is only that the dosage of Tween 80 is 0.

[0071] Comparative Example 2

[0072] This example provides an Acupuncture and Resuscitation Intelligence - Boosting Pill and its preparation method. The difference from Example 1 is only that the dosage of the complex enzyme is 0.

[0073] Comparative Example 3

[0074] This example provides an Acupuncture and Resuscitation Intelligence - Boosting Pill and its preparation method. The difference from Example 1 is only that the dosage of the complex enzyme is 0 and the dosage of Tween 80 is 0.

[0075] Test Example

[0076] In this example, the Morris water maze experiment was used to investigate the effect of the Acupuncture and Resuscitation Intelligence - Boosting Pills obtained in Examples 1 - 3 and Comparative Examples 1 - 3 on the escape latency of mice with learning and memory impairment induced by LPS.

[0077] The test method is as follows:

[0078] A number of ICR male mice weighing 18 - 22 g were selected and randomly divided into 8 groups, with 10 mice in each group: blank control group, model control (LPS) group, administration and treatment group of Example 1, administration and treatment group of Example 2, administration and treatment group of Example 3, administration and treatment group of Comparative Example 1, administration and treatment group of Comparative Example 2, and administration and treatment group of Comparative Example 3. The animals in each group were slightly anesthetized with chloral hydrate and their heads were fixed for intracerebroventricular injection. The model group, Examples 1 - 3, and Comparative Examples 1 - 3 groups (each group was given 150 mg / kg of the corresponding obtained Acupuncture and Resuscitation Intelligence - Boosting Pill) were injected with LPS solution (5 mg / ml, 3 μl / mouse), and the mice in the blank control group were injected with an equal volume of normal saline. Starting from the day after LPS injection, the mice in each Acupuncture and Resuscitation Intelligence - Boosting Pill administration group were intragastrically administered a solution prepared from the Acupuncture and Resuscitation Intelligence - Boosting Pill according to their body weight every day, and the mice in the blank group and the model group were intragastrically administered an equal volume of normal saline every day. The Morris water maze experiment was carried out starting from the 10th day and lasted for 5 days. The escape latency of the mice in the place navigation experiment was measured. The data statistics and analysis results are shown in Table 1.

[0079] Table 1

[0080] Test Group Escape Latency (s) Blank Group 37 Model Group 78 Administration and Treatment Group of Example 1 42 Administration and Treatment Group of Example 2 50 Administration and Treatment Group of Example 3 46 Administration and Treatment Group of Comparative Example 1 53 Administration and Treatment Group of Comparative Example 2 55 Administration and Treatment Group of Comparative Example 3 60

[0081] As can be seen from Table 1, the Acupuncture and Resuscitation Intelligence - Boosting Pills provided in Examples 1 - 3 of the present invention can significantly improve the spatial learning and memory ability of mice with learning and memory impairment induced by LPS, shorten the escape latency of mice in the place navigation experiment, and the intervention and treatment effects are significantly better than those of the administration and treatment groups of Comparative Examples 1 - 3.

[0082] In summary, the embodiments of the present invention provide an Acupuncture and Resuscitation Intelligence-Enhancing Pill, its preparation method and application. The traditional Chinese medicine composition provided by the present invention has the effects of acupuncture and resuscitation and intelligence enhancement, and animal experiments show that the Acupuncture and Resuscitation Intelligence-Enhancing Pill provided by the present invention can significantly improve the spatial learning and memory ability of mice with learning and memory impairment induced by LPS, and shorten the escape latency of mice in the place navigation experiment, providing a new treatment means for improving memory and cognitive function decline symptoms.

[0083] Various embodiments of the present invention may exist in the form of a range; it should be understood that the description in the form of a range is only for convenience and brevity, and should not be construed as a rigid limitation on the scope of the present invention; therefore, it should be considered that the range description has specifically disclosed all possible sub-ranges and single values within that range. For example, it should be considered that the range description from 1 to 6 has specifically disclosed sub-ranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., and single numbers within that range, such as 1, 2, 3, 4, 5, and 6, regardless of the range. Additionally, whenever a numerical range is indicated herein, it means including any cited number (fraction or integer) within the indicated range.

[0084] The above are only specific embodiments of the present invention, enabling those skilled in the art to understand or implement the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather to the broadest scope consistent with the principles and novel features claimed herein.

Claims

1. A pill for improving one's intelligence and improving one's moral, characterized in that: The Kaiqiao Yizhi Pills include a Chinese medicine composition and auxiliary materials. The Chinese medicine composition is prepared from the following components in parts by weight: 10-40 parts of Polygala (core removed), 8-20 parts of Alpinia oxyphylla, 15-35 parts of Acorus calamus (hair removed), 10-50 parts of Ginseng, 10-25 parts of Poria (wood bark removed), 8-15 parts of Morinda officinalis (core removed), 10-25 parts of Cuscuta seeds, 15-30 parts of Lycium bark, 8-15 parts of Polygonum multiflorum (processed), 12-20 parts of Salvia miltiorrhiza, 12-20 parts of Ziziphus jujuba seeds (fried), 8-15 parts of roasted tortoise shell, 8-15 parts of pearl, 15-20 parts of longan pulp, 12-20 parts of raw oyster, 12-20 parts of chicken's gizzard lining, 10-15 parts of chrysanthemum, 10-15 parts of atractylodes, 15-20 parts of astragalus, 6-8 parts of roasted liquorice, 8-15 parts of cyperus rotundus, 8-15 parts of curcuma, 10-15 parts of schisandra chinensis, 10-15 parts of raw rehmannia and 12-15 parts of chuanxiong.

2. The pill for improving resuscitation and improving intelligence according to claim 1, characterized in that: The Chinese medicine composition is prepared from the following components in parts by weight: 34.7 parts of Polygala (core removed), 11.5 parts of Alpinia oxyphylla, 20.1 parts of Acorus calamus (hair removed), 15.8 parts of Ginseng, 13.9 parts of Poria (bark removed), 10.3 parts of Morinda officinalis (core removed), 16.5 parts of Cuscuta chinensis, 20.6 parts of Rehmannia root bark, 9.9 parts of Polygonum multiflorum (processed), 15.1 parts of Salvia miltiorrhiza, 16.2 parts of Ziziphus jujuba seeds (fried), 11.3 parts of roasted Tortoise Shell, 10.0 parts of Pearl, 17.4 parts of Longan pulp, 15.0 parts of Raw Oyster, 16.9 parts of Chicken Gizzard Stone, 13.5 parts of Chrysanthemum, 12.8 parts of Atractylodes macrocephala, 16.6 parts of Astragalus, 7.0 parts of roasted Licorice root, 10.5 parts of Cyperus rotundus, 12.4 parts of Curcuma aromatica, 13.0 parts of Schisandra chinensis, 12.5 parts of Rehmannia root and 13.0 parts of Chuanxiong.

3. The pill for improving resuscitation and improving intelligence according to claim 1, characterized in that: The auxiliary material includes honey, and the weight ratio of the traditional Chinese medicine composition to the auxiliary material is 1:(1.3-1.7).

4. A method for preparing the pills for improving one's resuscitation and improving one's intelligence according to any one of claims 1 to 3, characterized in that: The preparation method of the aphrodisiac and intelligence-enhancing pill comprises the following steps: The Chinese medicine composition is crushed and sieved to obtain a first medicinal material fine powder with a particle size of 100 to 200 meshes; Placing the first medicinal material fine powder in a cavity of a low-temperature plasma treatment device for low-temperature plasma treatment, and then spraying the trehalose solution to obtain a second medicinal material fine powder; The second medicinal material powder and the complex enzyme are added to a solvent for gradient heating extraction, and then filtered and the obtained extract is concentrated and dried to obtain the traditional Chinese medicine composition; The Chinese medicine composition and auxiliary materials are mixed, and then pilled and dried to obtain the revelation-enhancing and intelligence-enhancing pills.

5. The method for preparing the pills for improving one's resuscitation and improving one's intelligence according to claim 4, characterized in that: The working condition parameters of the low-temperature plasma treatment include: using a mixed gas consisting of argon and oxygen in a volume ratio of 9:1 as the working medium, a discharge power of 240 to 330 W, and a treatment time of 60 to 120 seconds.

6. The method for preparing the pills for improving one's resuscitation and improving one's intelligence according to claim 5, characterized in that: The weight ratio of the second medicinal material powder, the complex enzyme and the solvent is 1:(0.005-0.01):(8-12); the complex enzyme is composed of cellulase and pectinase in a weight ratio of (2-5):

1.

7. The method for preparing the pills for improving one's resuscitation and improving one's intelligence according to claim 6, characterized in that: The solvent is prepared by adding 0.1 to 0.2% Tween 80, which accounts for 0.1 to 0.2% of the weight percentage of the solvent, to 40 to 50% of the volume percentage of the ethanol aqueous solution.

8. The method for preparing the pills for improving one's resuscitation and improving one's intelligence according to claim 7, characterized in that: The step of gradient heating extraction includes the following process: The first stage: stirring at 25-35°C for 30-60 minutes; The second stage: stirring at 80-85°C for 90-120 minutes.

9. The method for preparing the pills for improving one's resuscitation and improving one's intelligence according to claim 8, characterized in that: When honey is used as an auxiliary material, the steps of mixing the Chinese medicine composition and the auxiliary material, and then making pills and drying to obtain the invigorating and intelligent pills include the following processes: Refining the honey at 110-115° C. for 10-15 minutes, and then adding the Chinese medicine composition under continuous stirring to obtain a honey-medicine mass; The honey medicine mass is added into a pill-making machine for pill-making, and then dried to obtain the revelation-enhancing and intelligence-enhancing pills.

10. Use of the pills for improving memory and cognitive impairment as described in any one of claims 1 to 3 or the pills for improving memory and cognitive impairment as described in any one of claims 4 to 9.

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