Bone eliminating decoction for hyperostosis

Abstract

The invention discloses bone eliminating soup for hyperostosis. The bone eliminating soup is prepared from, by weight, 1-2 parts of Sichuan safflower, 1-2 parts of ligusticum wallichii, 3-5 parts of angelica sinensis, 4-6 parts of eucommia ulmoides, 4-6 parts of curcuma zedoary, 2-3 parts of radix saposhnikoviae, 2-3 parts of pepper, 3-4 parts of schizonepeta, 1-2 parts of myrrh, 1-2 parts of akebiaquinata, 1-2 parts of rhizoma sparganii, 1-2 parts of pseudo-ginseng and 1-2 parts of cape jasmine. The invention provides a more efficient, safer and personalized solution for overall treatment of hyperostosis.

Description

Technical Field

[0001] The invention relates to the technical field of bone-eliminating soup, in particular to a bone-eliminating soup for bone hyperplasia. Background Art

[0002] With the change of modern people's lifestyle and the intensification of the aging process, the incidence of bone hyperplasia, a common degenerative bone disease, continues to rise, especially in the middle-aged and elderly population. The disease is mainly manifested by local bone hyperplasia, pain, and limited mobility in the joints. In severe cases, it can affect the quality of daily life. At present, the clinical treatment methods for bone hyperplasia mainly include non-steroidal anti-inflammatory drugs, hormone drugs, physical therapy and surgical intervention, but most of these methods focus on symptom relief, and there are problems such as limited efficacy, large side effects or strong trauma. Therefore, more and more patients are beginning to seek traditional Chinese medicine as an alternative or auxiliary therapy.

[0003] Traditional Chinese medicine has long-term application experience in the treatment of bone hyperplasia. It is usually based on herbs that promote blood circulation and remove blood stasis, relax muscles and tendons, and strengthen tendons and bones. It works through oral decoctions and external plasters. However, in the traditional preparation process, water decoction is generally used to extract Chinese herbal ingredients. This high-temperature and short-time treatment method can easily cause the decomposition or activity reduction of some heat-sensitive components in the medicinal materials, especially medicinal materials containing volatile oils, phenols and polysaccharides. It is not easy to retain its efficacy under high temperature conditions, thus affecting the overall therapeutic effect. In addition, the traditional decoction method has low efficiency in extracting fat-soluble components in medicinal materials, which limits the release and synergistic effect of multiple effective ingredients.

[0004] In terms of preparation technology, the existing Chinese herbal medicine processing process usually does not fully consider the dissolution characteristics of different components in the medicinal materials in different solvents, and lacks targeted methods for the synergistic extraction of multiple polar components. At the same time, conventional Chinese herbal decoctions have poor stability, are easy to deteriorate, have a short shelf life, and are difficult to standardize and mass produce, which is not conducive to clinical application and promotion.

[0005] In terms of treatment mechanism, existing technologies focus on relieving pain and inflammation caused by bone hyperplasia, but ignore the multi-factorial mechanism of bone hyperplasia, such as bone metabolism disorder, local microcirculation disorder, and persistent chronic inflammation. It is difficult for a single drug or local treatment to achieve a comprehensive intervention in complex pathological conditions.

[0006] Therefore, there is an urgent need for a new Chinese medicine preparation scheme that can improve the bioavailability without destroying the activity of the active ingredients and achieve systematic intervention in the pathological state of bone hyperplasia, thereby improving the overall therapeutic effect. Summary of the invention

[0007] One purpose of the present invention is to provide a bone-eliminating soup for bone hyperplasia, which provides a more efficient, safe and personalized solution for the overall treatment of bone hyperplasia.

[0008] A bone-removing soup for bone hyperplasia according to an embodiment of the present invention comprises the following raw materials by weight:

[0009] 1-2 parts of safflower, 1-2 parts of chuanxiong, 3-5 parts of angelica, 4-6 parts of eucommia, 4-6 parts of curcuma, 2-3 parts of siler, 2-3 parts of pepper, 3-4 parts of schizonepeta, 1-2 parts of myrrh, 1-2 parts of akebia, 1-2 parts of trillium, 1-2 parts of panax notoginseng, and 1-2 parts of gardenia.

[0010] A method for preparing a bone-removing soup for bone hyperplasia, comprising the following steps:

[0011] S1. Select Chinese medicinal materials including safflower, chuanxiong, angelica, eucommia, curcuma, saposhnikovia, pepper, schizonepeta, myrrh, akebia, sparganium, notoginseng and gardenia as raw materials, weigh and mix them according to the set weight ratio to form a medicinal mixture;

[0012] S2. placing the medicinal material mixture in a sealed container, adding 30%-50% by volume of edible alcohol as the first solvent, and adding an equal volume of edible vinegar as the second solvent, wherein the total volume of the wine-vinegar mixed solvent is 3-5 times the volume of the medicinal material mixture;

[0013] S3. Place the sealed container containing the medicinal material mixture and the wine vinegar mixed solvent in a light-proof and ventilated environment for static soaking, set the soaking period to 30 days, keep the room temperature stable between 15-25°C during this period, and gently shake the container once a day to enhance the contact efficiency between the medicinal material and the solvent;

[0014] S4. After the soaking period, the obtained soaking liquid was coarsely filtered to remove the residue, collect the preliminary filtrate, and use a filter cloth of 120 mesh or more to perform secondary fine filtration on the preliminary filtrate to obtain a clear and uniform liquid preparation of Xiaogutang;

[0015] S5. The obtained liquid preparation of Xiaogutang is sterilized by low-temperature pasteurization process, the temperature is controlled at 60-65 ° C, and the duration is 30-45 minutes to keep the active ingredient stable;

[0016] S6. Package the sterilized liquid preparation of Bone-Dismantling Soup into sealed packaging containers, attach labels and store them in a cool and dry place to form a finished product of Bone-Dismantling Soup that can be drunk directly or used under the guidance of a doctor.

[0017] Optionally, S2 includes the following steps:

[0018] S21. The weighed and mixed medicinal material mixture is placed in a dry and sterile sealed container, the sealed container is made of glass or stainless steel, the volume is 5-10 times the volume of the medicinal material mixture, and the container is ensured to have alkyd corrosion resistance and good sealing performance;

[0019] S22. Add 30%-50% edible alcohol by volume to the sealed container, wherein the alcohol is made from grain-brewed liquor, and the amount added is 1.5-2.5 times the volume of the medicinal mixture;

[0020] S23. Adding an edible vinegar having an equal volume to the edible alcohol to the sealed container, wherein the edible vinegar is selected from naturally brewed rice vinegar or aged vinegar, and the acidity thereof is not less than 4%, and the vinegar is in full contact with the alcohol to form a wine-vinegar mixed solvent;

[0021] S24. Control the total volume of the wine-vinegar mixed solvent to be 3-5 times the volume of the medicinal material mixture to ensure that the medicinal material mixture is completely immersed in the solution without leaving any bubble interlayer, thereby forming a preliminary immersion system.

[0022] Optionally, S3 includes the following steps:

[0023] S31. Place the sealed container containing the medicinal material mixture and the wine vinegar mixed solvent in a light-proof and ventilated environment, the environment should be away from heat sources and direct light, and the humidity should be controlled between 40% and 60% to ensure that the external environment of the container is stable during the soaking process;

[0024] S32. The sealed container is left to soak for a continuous period of 30 days. During the soaking process, the container is always kept sealed to prevent impurities from entering and the active ingredients from volatilizing;

[0025] S33. During the entire soaking period, the ambient temperature is controlled to be stable between 15°C and 25°C, and the temperature fluctuation range is controlled to not exceed ±2°C under natural constant temperature or constant temperature room conditions;

[0026] S34. Gently shake the container manually or mechanically once a day at a fixed time, with the shaking amplitude controlled between 5-10 cm up and down, and the duration being 30-60 seconds, to ensure uniform contact between the medicinal materials and the wine and vinegar mixed solvent and efficient component exchange.

[0027] Optionally, S4 includes the following steps:

[0028] S41. After completing the 30-day soaking cycle, the sealed container is opened, and the soaking liquid is subjected to the first coarse filtration operation using a coarse-mesh filter with a pore size of 1.0 mm to 2.0 mm to remove large particles of drug residues, and the preliminary filtrate is collected in a clean container;

[0029] S42. The preliminary filtrate is allowed to settle for 2 to 4 hours, and after the suspended matter has naturally settled, the supernatant is carefully poured out to avoid disturbing the sediment layer;

[0030] S43. Use 120-200 mesh stainless steel filter cloth or equivalent microporous fiber filter material to perform a second fine filtration on the upper clear liquid. During the fine filtration process, keep the filter cloth tension uniform and control the filtration speed to 100 to 200 ml per minute to ensure a stable filtrate flow rate;

[0031] S44. Collect the liquid preparation after fine filtration, which is a clear and uniform liquid with a light brown to brown color and no visible suspended matter or precipitation, as the final finished product of the bone-eliminating soup stock solution.

[0032] Optionally, S5 includes the following steps:

[0033] S51. The liquid preparation of Xiaogutang after fine filtration is placed in a heat-resistant container, wherein the container is made of food-grade certified stainless steel or high borosilicate glass material, having good thermal conductivity and sealing properties;

[0034] S52. The container is placed in a pasteurization device, sterilized by low-temperature constant temperature heating, the temperature is slowly increased to 60°C to 65°C, and maintained at a constant temperature;

[0035] S53. After the temperature stabilizes, continue the heat preservation process for 30 minutes to 45 minutes. During the sterilization process, the temperature fluctuation is continuously monitored by the external temperature control system, and the temperature error is controlled to not exceed ±1°C;

[0036] S54. After the sterilization time is over, immediately remove the container from the heating system and use natural cooling or flowing cold water to quickly reduce the temperature of the liquid preparation to room temperature in the range of 20°C to 25°C to inhibit the degradation or denaturation of the active ingredients after sterilization.

[0037] The beneficial effects of the present invention are:

[0038] (1) The present invention mixes 30%-50% edible alcohol by volume with an equal volume of edible vinegar to form a dual solvent system, and controls the total volume of the alcohol-vinegar mixed solvent to be 3-5 times the volume of the medicinal material mixture. Set a period of 30 days, static soaking in a low temperature environment of 15-25°C, and promote solute diffusion by gently shaking every day. Compared with the traditional high-temperature decoction process, this method greatly improves the dissolution rate of fat-soluble and partially water-soluble components without destroying heat-sensitive components. At the same time, the synergistic effect of alcohol and vinegar promotes the formation of natural complexes in medicinal materials, thereby improving the stability of the components and the consistency of the efficacy, and constructing a Chinese medicine liquid preparation model that is more suitable for industrial extraction and long-term storage.

[0039] (2) The present invention follows the theory of monarch, minister, assistant and envoy in the selection and proportion control of Chinese medicine, and combines the modern pharmacological research foundation to select 14 Chinese medicines such as safflower, chuanxiong, angelica, eucommia, curcuma, and saposhnikovia to form a synergistic prescription system with multiple effects of anti-inflammatory, blood circulation, analgesia, and bone metabolism regulation. A system intervention model based on the complex pathological state of bone hyperplasia is constructed, taking into account the three core links of local inflammation control, bone cell regulation and microcirculation improvement, reflecting the modern Chinese medicine innovation model of multi-factor coupling intervention, and providing a more efficient, safe and personalized solution for the overall treatment of bone hyperplasia. DETAILED DESCRIPTION

[0041] A bone-removing soup for bone hyperplasia, comprising the following raw materials by weight:

[0042] 1-2 parts of safflower, 1-2 parts of chuanxiong, 3-5 parts of angelica, 4-6 parts of eucommia, 4-6 parts of curcuma, 2-3 parts of siler, 2-3 parts of pepper, 3-4 parts of schizonepeta, 1-2 parts of myrrh, 1-2 parts of akebia, 1-2 parts of trillium, 1-2 parts of panax notoginseng, and 1-2 parts of gardenia.

[0043] A method for preparing a bone-removing soup for bone hyperplasia, comprising the following steps:

[0044] S1. Select Chinese medicinal materials including safflower, chuanxiong, angelica, eucommia, curcuma, saposhnikovia, pepper, schizonepeta, myrrh, akebia, sparganium, notoginseng and gardenia as raw materials, weigh and mix them according to the set weight ratio to form a medicinal mixture;

[0045] S2. placing the medicinal material mixture in a sealed container, adding 30%-50% by volume of edible alcohol as the first solvent, and adding an equal volume of edible vinegar as the second solvent, wherein the total volume of the wine-vinegar mixed solvent is 3-5 times the volume of the medicinal material mixture;

[0046] S3. Place the sealed container containing the medicinal material mixture and the wine vinegar mixed solvent in a light-proof and ventilated environment for static soaking, set the soaking period to 30 days, keep the room temperature stable between 15-25°C during this period, and gently shake the container once a day to enhance the contact efficiency between the medicinal material and the solvent;

[0047] S4. After the soaking period, the obtained soaking liquid was coarsely filtered to remove the residue, collect the preliminary filtrate, and use a filter cloth of 120 mesh or more to perform secondary fine filtration on the preliminary filtrate to obtain a clear and uniform liquid preparation of Xiaogutang;

[0048] S5. The obtained liquid preparation of Xiaogutang is sterilized by low-temperature pasteurization process, the temperature is controlled at 60-65 ° C, and the duration is 30-45 minutes to keep the active ingredient stable;

[0049] S6. Package the sterilized liquid preparation of Bone-Dismantling Soup into sealed packaging containers, attach labels and store them in a cool and dry place to form a finished product of Bone-Dismantling Soup that can be drunk directly or used under the guidance of a doctor.

[0050] In this implementation, S2 includes the following steps:

[0051] S21. Place the weighed and mixed medicinal material mixture in a dry and sterile sealed container, the sealed container is made of glass or stainless steel, the volume is 5-10 times the volume of the medicinal material mixture, and ensure that the container has alkyd corrosion resistance and good sealing performance;

[0052] S22. Add 30%-50% edible alcohol by volume to a sealed container, wherein the alcohol is selected from grain-brewed liquor, and the amount added is 1.5-2.5 times the volume of the medicinal mixture;

[0053] S23. Adding an edible vinegar having an equal volume of edible alcohol to the sealed container, wherein the edible vinegar is selected from naturally brewed rice vinegar or aged vinegar, the acidity of which is not less than 4%, and is in full contact with the alcohol to form a wine-vinegar mixed solvent;

[0054] S24. Control the total volume of the wine-vinegar mixed solvent to be 3-5 times the volume of the medicinal material mixture to ensure that the medicinal material mixture is completely immersed in the solution without leaving any bubble interlayer, thereby forming a preliminary soaking system.

[0055] In this implementation, S3 includes the following steps:

[0056] S31. Place the sealed container containing the medicinal material mixture and the wine and vinegar mixed solvent in a light-proof and ventilated environment, away from heat sources and direct light, and control the humidity between 40% and 60% to ensure that the external environment of the container is stable during the soaking process;

[0057] S32. The sealed container is left to soak for a continuous period of 30 days. During the soaking process, the container is always kept sealed to prevent impurities from entering and the active ingredients from volatilizing;

[0058] S33. During the entire soaking period, the ambient temperature is controlled to be stable between 15°C and 25°C, and the temperature fluctuation range is controlled to not exceed ±2°C under natural constant temperature or constant temperature room conditions;

[0059] S34. Gently shake the container manually or mechanically once a day at a fixed time, with the shaking amplitude controlled between 5-10 cm up and down, and the duration being 30-60 seconds, to ensure uniform contact between the medicinal materials and the wine and vinegar mixed solvent and efficient component exchange.

[0060] In this implementation, S4 includes the following steps:

[0061] S41. After completing the 30-day soaking cycle, the sealed container is opened, and the soaking liquid is subjected to the first coarse filtration operation using a coarse-mesh filter with a pore size of 1.0 mm to 2.0 mm to remove large particles of drug residues, and the preliminary filtrate is collected in a clean container;

[0062] S42. The preliminary filtrate is allowed to settle for 2 to 4 hours, and after the suspended matter has naturally settled, the supernatant is carefully poured out to avoid disturbing the sediment layer;

[0063] S43. Use 120-200 mesh stainless steel filter cloth or equivalent microporous fiber filter material to perform a second fine filtration on the upper clear liquid. During the fine filtration process, keep the filter cloth tension uniform and control the filtration speed to 100 to 200 ml per minute to ensure a stable filtrate flow rate;

[0064] S44. Collect the liquid preparation after fine filtration. The liquid preparation is a clear and uniform liquid with a light brown to brown color and no visible suspended matter or precipitation, and serve as the final finished product of the bone-eliminating soup concentrate.

[0065] In this implementation, S5 includes the following steps:

[0066] S51. Place the finely filtered liquid preparation of Xiaogutang into a heat-resistant container, the container is made of food-grade certified stainless steel or high borosilicate glass, and has good thermal conductivity and sealing properties;

[0067] S52. Place the container in a pasteurization device and sterilize it by low-temperature constant temperature heating, slowly increase the temperature to a range of 60°C to 65°C, and maintain a constant temperature;

[0068] S53. After the temperature stabilizes, continue the heat preservation process for 30 minutes to 45 minutes. During the sterilization process, the temperature fluctuation is continuously monitored by the external temperature control system, and the temperature error is controlled to not exceed ±1°C;

[0069] S54. After the sterilization time is over, immediately remove the container from the heating system and use natural cooling or flowing cold water to quickly reduce the temperature of the liquid preparation to room temperature in the range of 20°C to 25°C to inhibit the degradation or denaturation of the active ingredients after sterilization.

[0070] Embodiment 1:

[0071] In March 2024, a 62-year-old male patient named Wang came to the outpatient clinic of the Rehabilitation Medicine Department of the Traditional Chinese Medicine Hospital of City A for "knee joint pain and limited activity". The symptoms had lasted for 18 months. X-ray and MRI examinations showed that the subchondral bone density of both knees was increased, and obvious osteophytes were formed in the intercondylar spines and joint edges. Combined with the symptoms and signs, he was diagnosed with moderate bone hyperplasia (knee osteoarthritis stage II). The patient's daily activity ability decreased, the pain worsened at night, and he had been dependent on nonsteroidal anti-inflammatory drugs for more than 1 year. Frequent medication caused stomach discomfort, and he was eager to find a milder, long-term and effective alternative treatment.

[0072] In view of the patient's condition, the rehabilitation department adopted the preparation method of the bone-removing soup for bone hyperplasia of the present invention for trial intervention, and compared it with 6 patients with similar symptoms who were treated with traditional Chinese medicine decoctions during the same period, and conducted efficacy comparison in four aspects: duration of drug efficacy, improvement in pain scores, changes in serum bone metabolism indicators and quality of life scores, in order to verify the actual effect of the method of the present invention.

[0073] The preparation process of Xiaogu Decoction is as follows:

[0074] The bone-clearing soup of the present invention is composed of the following 14 medicinal materials: 10g of Sichuan safflower, 12g of Chuanxiong, 10g of Chinese angelica, 15g of Eucommia ulmoides, 10g of Curcuma zedoaria, 10g of Saposhnikovia divaricata, 5g of Piper nipponicae, 8g of Nepeta tenuifolia, 10g of Myrrha, 8g of Akebia, 10g of Tripterygium wilfordii, 8g of Panax notoginseng, and 10g of Gardenia jasminoides. The above medicinal materials are weighed in proportion, mixed, and placed in a 5L glass sealed jar.

[0075] Then add 2000ml of edible-grade 38-proof kaoliang wine and 2000ml of naturally brewed rice vinegar (with an acetic acid concentration of about 4.5%) to form a wine-vinegar mixture, ensuring that all the medicinal materials are immersed. After mixing, seal it and place it in a 22°C constant temperature and light-proof storage cabinet for soaking for 30 days. During this period, the automatic mechanical shaker gently shakes it for 30 seconds at 8:00 am every day to promote uniform exchange of the medicinal liquid. After the 30th day, first use a 1000μm pore size filter to coarsely filter to remove large pieces of medicinal residues, and then use a 200-mesh filter cloth for fine filtration to obtain a clear brown-yellow liquid stock solution.

[0076] To ensure drinking safety and ingredient stability, the stock solution is pasteurized at 60°C for 40 minutes and quickly cooled to room temperature. It is then packaged in brown glass bottles of 100 ml / bottle and taken twice a day, 50 ml each time, warm in the morning and evening. (This product is for external use, and should be applied externally for 1 hour each day).

[0077] The trial period lasted for 60 consecutive days, and the intervention results were as follows:

[0078]

[0079]

[0080] In addition, we compared the extraction rates of ingredients of the method of the present invention with those of the traditional water decoction process during the preparation of the preparation, and selected notoginseng total saponins, ligustrazine and eucommia ulmoides phenols as representative ingredients for content determination, as follows:

[0081]

[0082] After taking the Xiaogu Decoction preparation of the present invention for 60 consecutive days, the patient Wang's spontaneous pain score decreased significantly, the night pain was significantly relieved, and the knee joint range of motion was improved to a near normal level. Compared with the traditional water decoction control group, Xiaogu Decoction showed more obvious advantages in anti-inflammatory, analgesic and bone metabolism regulation, and was superior to the traditional method in terms of drug efficacy maintenance time, component extraction rate and compliance.

[0083] It can be seen from the test data that the present invention has indeed solved the problems of easy loss of ingredients, low bioavailability and single mechanism of action in the traditional decoction process in practical application, and has achieved standardization of preparation quality and systematic control of efficacy through dual solvent synergistic extraction and low-temperature activation soaking key process innovation. Clinical feedback also shows that it has low side effects, good palatability and is easy to use, making it suitable as one of the core drugs for the mid- to long-term management of bone hyperplasia in the middle-aged and elderly population.

[0084] Example 1 truly restores the actual application scenario of the present invention in a hospital outpatient clinic, and verifies the practical value and technical innovation of the method of the present invention in improving treatment effects, ensuring drug stability and enhancing patient compliance through comparative experiments and chemical composition detection data.

[0085] The present invention mixes 30%-50% edible alcohol by volume with an equal volume of edible vinegar to form a dual solvent system, and controls the total volume of the alcohol-vinegar mixed solvent to be 3-5 times the volume of the medicinal material mixture. Set a period of 30 days, static soaking in a low temperature environment of 15-25°C, and promote solute diffusion by gently shaking every day. Compared with the traditional high-temperature decoction process, this method greatly improves the dissolution rate of fat-soluble and partially water-soluble components without destroying heat-sensitive components. At the same time, the synergistic effect of alcohol and vinegar promotes the formation of natural complexes in medicinal materials, thereby improving the stability of the components and the consistency of the efficacy, and constructing a Chinese medicine liquid preparation model that is more suitable for industrial extraction and long-term storage.

[0086] The present invention follows the theory of monarch, minister, assistant and envoy in traditional Chinese medicine in terms of medicinal material selection and proportion control, and combines the modern pharmacological research foundation to select 14 Chinese medicinal materials such as Sichuan safflower, Chuanxiong, Angelica, Eucommia, Curcuma, and Saposhnikovia to form a synergistic prescription system with multiple effects of anti-inflammatory, blood circulation, analgesia, and bone metabolism regulation. A system intervention model based on the complex pathological state of bone hyperplasia is constructed, taking into account the three core links of local inflammation control, bone cell regulation and microcirculation improvement, reflecting the modern Chinese medicine innovation model of multi-factor coupling intervention, and providing a more efficient, safe and personalized solution for the overall treatment of bone hyperplasia.

[0087] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A bone-removing soup for bone hyperplasia, characterized in that: The preparation raw materials include the following weight components: 1-2 parts of safflower, 1-2 parts of chuanxiong, 3-5 parts of angelica, 4-6 parts of eucommia, 4-6 parts of curcuma, 2-3 parts of siler, 2-3 parts of pepper, 3-4 parts of schizonepeta, 1-2 parts of myrrh, 1-2 parts of akebia, 1-2 parts of trillium, 1-2 parts of panax notoginseng, and 1-2 parts of gardenia.

2. A method for preparing a bone-removing soup for bone hyperplasia, used for preparing a bone-removing soup for bone hyperplasia according to claim 1, characterized in that: The steps include: S1. Select Chinese medicinal materials including safflower, chuanxiong, angelica, eucommia, curcuma, saposhnikovia, pepper, schizonepeta, myrrh, akebia, sparganium, notoginseng and gardenia as raw materials, weigh and mix them according to the set weight ratio to form a medicinal mixture; S2. placing the medicinal material mixture in a sealed container, adding 30%-50% by volume of edible alcohol as the first solvent, and adding an equal volume of edible vinegar as the second solvent, wherein the total volume of the wine-vinegar mixed solvent is 3-5 times the volume of the medicinal material mixture; S3. Place the sealed container containing the medicinal material mixture and the wine vinegar mixed solvent in a light-proof and ventilated environment for static soaking, set the soaking period to 30 days, keep the room temperature stable between 15-25°C during this period, and gently shake the container once a day to enhance the contact efficiency between the medicinal material and the solvent; S4. After the soaking period, the obtained soaking liquid was coarsely filtered to remove the residue, collect the preliminary filtrate, and use a filter cloth of 120 mesh or more to perform secondary fine filtration on the preliminary filtrate to obtain a clear and uniform liquid preparation of Xiaogutang; S5. The obtained liquid preparation of Xiaogutang is sterilized by low-temperature pasteurization process, the temperature is controlled at 60-65 ° C, and the duration is 30-45 minutes to keep the active ingredient stable; S6. Package the sterilized liquid preparation of bone-diminishing soup into sealed packaging containers, attach labels and store them in a cool and dry place to form a finished product of bone-diminishing soup that can be drunk directly or used under the guidance of a doctor.

3. The method for preparing the bone-removing soup for bone hyperplasia according to claim 2, characterized in that: The S2 comprises the following steps: S21. The weighed and mixed medicinal material mixture is placed in a dry and sterile sealed container, the sealed container is made of glass or stainless steel, the volume is 5-10 times the volume of the medicinal material mixture, and the container is ensured to have alkyd corrosion resistance and good sealing performance; S22. Add 30%-50% edible alcohol by volume to the sealed container, wherein the alcohol is made from grain-brewed liquor, and the amount added is 1.5-2.5 times the volume of the medicinal mixture; S23. Adding an edible vinegar having an equal volume to the edible alcohol to the sealed container, wherein the edible vinegar is selected from naturally brewed rice vinegar or aged vinegar, and the acidity thereof is not less than 4%, and the vinegar is in full contact with the alcohol to form a wine-vinegar mixed solvent; S24. Control the total volume of the wine-vinegar mixed solvent to be 3-5 times the volume of the medicinal material mixture to ensure that the medicinal material mixture is completely immersed in the solution without leaving any bubble interlayer, thereby forming a preliminary immersion system.

4. The method for preparing the bone-removing soup for bone hyperplasia according to claim 2, characterized in that: The S3 comprises the following steps: S31. Place the sealed container containing the medicinal material mixture and the wine vinegar mixed solvent in a light-proof and ventilated environment, the environment should be away from heat sources and direct light, and the humidity should be controlled between 40% and 60% to ensure that the external environment of the container is stable during the soaking process; S32. The sealed container is left to soak for a continuous period of 30 days. During the soaking process, the container is always kept sealed to prevent impurities from entering and the active ingredients from volatilizing; S33. During the entire soaking period, the ambient temperature is controlled to be stable between 15°C and 25°C, and the temperature fluctuation range is controlled to not exceed ±2°C under natural constant temperature or constant temperature room conditions; S34. Gently shake the container manually or mechanically once a day at a fixed time, with the shaking amplitude controlled between 5-10 cm up and down, and the duration being 30-60 seconds, to ensure uniform contact between the medicinal materials and the wine and vinegar mixed solvent and efficient component exchange.

5. The method for preparing the bone-removing soup for bone hyperplasia according to claim 1, characterized in that: The S4 comprises the following steps: S41. After completing the 30-day soaking cycle, the sealed container is opened, and the soaking liquid is subjected to the first coarse filtration operation using a coarse-mesh filter with a pore size of 1.0 mm to 2.0 mm to remove large particles of drug residues, and the preliminary filtrate is collected in a clean container; S42. The preliminary filtrate is allowed to settle for 2 to 4 hours, and after the suspended matter has naturally settled, the supernatant is carefully poured out to avoid disturbing the sediment layer; S43. Use 120-200 mesh stainless steel filter cloth or equivalent microporous fiber filter material to perform a second fine filtration on the upper clear liquid. During the fine filtration process, keep the filter cloth tension uniform and control the filtration speed to 100 to 200 ml per minute to ensure a stable filtrate flow rate; S44. Collect the liquid preparation after fine filtration, which is a clear and uniform liquid with a light brown to brown color and no visible suspended matter or precipitation, as the final finished product of the bone-eliminating soup stock solution.

6. The method for preparing the bone-removing soup for bone hyperplasia according to claim 1, characterized in that: The S5 comprises the following steps: S51. The liquid preparation of Xiaogutang after fine filtration is placed in a heat-resistant container, wherein the container is made of food-grade certified stainless steel or high borosilicate glass material, having good thermal conductivity and sealing properties; S52. The container is placed in a pasteurization device, sterilized by low-temperature constant temperature heating, the temperature is slowly increased to 60°C to 65°C, and maintained at a constant temperature; S53. After the temperature stabilizes, continue the heat preservation process for 30 minutes to 45 minutes. During the sterilization process, the temperature fluctuation is continuously monitored by the external temperature control system, and the temperature error is controlled to not exceed ±1°C; S54. After the sterilization time is over, immediately remove the container from the heating system and use natural cooling or flowing cold water to quickly reduce the temperature of the liquid preparation to room temperature in the range of 20°C to 25°C to inhibit the degradation or denaturation of the active ingredients after sterilization.

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