Blood purification device for extracorporeal circulation blood path

Abstract

The invention provides a blood purification device for an extracorporeal circulation blood path, and belongs to the technical field of blood purification devices, the blood purification device comprises a first artery end blood vessel, a first peristaltic pump, a second artery end blood vessel, a blood treatment part, a first vein end blood vessel, a second peristaltic pump, a second vein end blood vessel and a PLC control system; one end of the first peristaltic pump is connected with the artery end blood vessel I, and the other end is connected with the artery end blood vessel II; one end of the second peristaltic pump is connected with the vein end blood vessel I, and the other end is connected with the vein end blood vessel II; a semipermeable membrane is arranged in the center of the blood treatment part, and the blood treatment part is divided into a blood side and a dialysate side through the semipermeable membrane; a liquid inlet pipe is arranged on one side of the dialysate side, and a liquid discharge pipeline is arranged at the bottom of the dialysate side; and a plurality of groups of air bag parts are arranged in the dialysate side. The air bag part is periodically inflated and deflated, so that the sectional area of the dialysate side is dynamically changed, small-molecule toxins are prevented from forming a dead zone locally in the area near the semipermeable membrane, and the overall dialysis effect is improved.

Description

Technical Field

[0001] The present invention belongs to the technical field of blood purification devices, and particularly relates to a blood purification device for an extracorporeal circulation blood circuit. Background Art

[0002] A blood purification device is a medical device used to remove harmful substances from the blood and regulate the balance of water and electrolytes. It is widely used in the treatment of various diseases. It works by draining the blood in the body to the outside of the body and passing it through a dialyzer composed of countless hollow fibers. Substance exchange occurs between the blood and an electrolyte solution (dialysate) with a concentration similar to that of the body through diffusion / convection inside and outside the hollow fibers, removing metabolic wastes in the body, maintaining the balance of electrolytes and acid-base, simultaneously removing excess water in the body, and then returning the purified blood.

[0003] As of the end of December 2022, the number of hemodialysis patients in China reached 844,265, and the number of newly added hemodialysis patients was 156,645, which was 3.6 times that in 2011. With the wide coverage of medical insurance and the improvement of dialysis technology and treatment capabilities, more and more patients can receive long-term treatment and survival, and the dialysis age of blood purification patients has increased significantly. As of the end of 2022, the proportion of patients with a dialysis age of more than 5 years has reached 33.7%.

[0004] After retrieval, CN115105660B discloses an extracorporeal circulation pipeline assembly of a blood purification device, including: an arterial pipeline and a venous pipeline, and pipeline clamps are provided on both the arterial pipeline and the venous pipeline; the pipeline clamp includes a clamp body and a snap ring detachably connected to the clamp body; the clamp body has a hollow inner cavity, a notch communicating with the hollow inner cavity is provided on the clamp body, a buckle is provided on the notch; the outer side surface of the clamp body includes a clamp installation surface, a positioning hole and a receiving hole are oppositely arranged on the clamp body, a ring body bayonet is provided on the snap ring, and the outer side surface of the snap ring includes a ring body installation surface, and two oppositely arranged brackets are provided on the ring body installation surface of the snap ring, and an installation bump is provided on each bracket. The extracorporeal circulation pipeline assembly of the blood purification device of the present invention can quickly find the pipeline clamp and the clamp body can be quickly disassembled and closed, improving the quickness of handling abnormal situations and the safety of the extracorporeal circulation pipeline assembly.

[0005] The above-mentioned patent documents mainly focus on the safety optimization of the blood side in blood purification devices. For example, pipeline clamps are used to ensure the safe operation of the extracorporeal circulation pipeline components. However, the core process of blood purification is carried out through a dialysis membrane. Although the pressure values at each stage on the blood side can currently be controlled by precise pressure regulating elements and dialysis is carried out using the concentration difference gradient, during the flow of dialysis fluid in the prior art, a boundary layer will form on the surface of the semi-permeable membrane, resulting in a significant reduction in the fluid velocity in this area, which is prone to form a dead zone, thus affecting the dialysis efficiency. At the same time, due to the need to use a large amount of fresh dialysis fluid, it may cause excessive pressure on the dialysis fluid side. Once the pressure on the dialysis fluid side exceeds the pressure on the blood side, it may cause the dialysis membrane to rupture, leading to serious complications such as patient blood loss or infection. Summary of the Invention

[0006] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a blood purification device for an extracorporeal circulation blood path, which effectively solves the problems in the prior art that during the flow of dialysis fluid, a boundary layer will form on the surface of the semi-permeable membrane, resulting in a significant reduction in the fluid velocity in this area, which is prone to form a dead zone, thus affecting the dialysis efficiency. At the same time, due to the need to use a large amount of fresh dialysis fluid, it may cause excessive pressure on the dialysis fluid side. Once the pressure on the dialysis fluid side exceeds the pressure on the blood side, it may cause the dialysis membrane to rupture, leading to serious complications such as patient blood loss or infection.

[0007] To achieve the above purpose, the present invention provides the following technical solutions: A blood purification device for an extracorporeal circulation blood path, comprising an arterial end blood vessel one, a first peristaltic pump, an arterial end blood vessel two, a blood treatment unit, a venous end blood vessel one, a second peristaltic pump, a venous end blood vessel two, and a PLC control system;

[0008] The inlet end of the first peristaltic pump is connected to the arterial end blood vessel one, and the outlet end of the first peristaltic pump is connected to the arterial end blood vessel two;

[0009] The inlet end of the second peristaltic pump is connected to the venous end blood vessel one, and the outlet end of the second peristaltic pump is connected to the venous end blood vessel two;

[0010] A semi-permeable membrane is provided in the center of the blood treatment unit. Through the semi-permeable membrane, the blood treatment unit is divided into a blood side and a dialysis fluid side. The arterial end blood vessel two is communicated with the blood side, and the venous end blood vessel one is communicated with the blood side;

[0011] An inlet pipe is provided on the side of the dialysis fluid side away from the semi-permeable membrane, and a drainage pipeline is provided at the bottom of the dialysis fluid side;

[0012] A number of groups of air bag parts are provided inside the dialysis fluid side. The air bag part includes a first air bag and a second air bag.

[0013] As a preferred embodiment of the present invention, a bypass liquid storage tank is provided outside the dialysate side. A bypass pipeline is connected to the rear end of the bypass liquid storage tank. The bypass pipeline is communicated with the dialysate side. A second overflow valve is provided on one side of the bypass liquid storage tank away from the bypass pipeline. A liquid level sensor is provided on the front surface of the bypass liquid storage tank. A first electromagnetic valve and a second one-way valve are provided on the bypass pipeline.

[0014] As a preferred embodiment of the present invention, a booster pump is provided on the liquid inlet pipe. The dialysate is pumped into the dialysate side through the booster pump. A first overflow valve is provided on the bypass of the liquid inlet pipe. The first overflow valve is communicated with the bypass liquid storage tank. A second electromagnetic valve is provided on the liquid discharge pipeline.

[0015] As a preferred embodiment of the present invention, the air inlet end of the first airbag is connected to an airbag air inlet pipeline. The airbag air inlet pipeline is a three-way pipeline. The total inlet of the airbag air inlet pipeline is connected to an external air compressor. A third electromagnetic valve and a fourth electromagnetic valve are provided on the airbag air inlet pipeline. The fourth electromagnetic valve is located at the front end of the second airbag.

[0016] As a preferred embodiment of the present invention, the rear end of the first airbag is connected to a first airbag exhaust pipeline. The rear end of the second airbag is connected to a second airbag exhaust pipeline. A fifth electromagnetic valve is provided on the first airbag exhaust pipeline. A sixth electromagnetic valve is provided on the second airbag exhaust pipeline. During operation, the opening states of the third electromagnetic valve and the fourth electromagnetic valve are opposite. The opening states of the third electromagnetic valve and the sixth electromagnetic valve are the same. The opening states of the fourth electromagnetic valve and the fifth electromagnetic valve are the same.

[0017] As a preferred embodiment of the present invention, both the first airbag and the second airbag are fixedly connected to the frame of the blood side through brackets. The first airbag and the second airbag are arranged alternately within the blood side.

[0018] As a preferred embodiment of the present invention, a blood sampling port and a first pressure sensor are provided on the first arterial end blood vessel. A second pressure sensor and a first one-way valve are provided on the second arterial end blood vessel.

[0019] As a preferred embodiment of the present invention, a slag discharge pipe is connected to the bottom of the blood side. A stop valve is provided on the slag discharge pipe.

[0020] As a preferred embodiment of the present invention, a blood sampling port and a third pressure sensor are provided on the first venous end blood vessel. A fourth pressure sensor is provided on the second venous end blood vessel.

[0021] As a preferred embodiment of the present invention, a temperature regulating element and a temperature sensor are further provided on the venous end blood vessel II, wherein the temperature regulating element is located at the rear end of the fourth pressure sensor, and the temperature sensor is located at the rear end of the temperature regulating element.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] (1) The blood purification device of an extracorporeal blood circuit provided by the present invention, by providing an airbag part, enables the first airbag and the second airbag to be periodically inflated and deflated, so that the cross-sectional area on the dialysate side changes dynamically. This dynamic change promotes the full mixing of small molecule toxins that have diffused to the dialysate side with the dialysate, avoiding the local enrichment of small molecule toxins in the area near the semipermeable membrane to form a dead zone, thereby improving the overall dialysis effect.

[0024] (2) The blood purification device of an extracorporeal blood circuit provided by the present invention, through the pressure setting of the first overflow valve and the second overflow valve, ensures that the pressure on the dialysate side is always lower than the pressure on the blood side. A plurality of pressure sensors are provided on the arteriovenous blood vessels to achieve full-process pressure monitoring and ensure the safety during the treatment process.

[0025] (3) The blood purification device of an extracorporeal blood circuit provided by the present invention is provided with a bypass liquid storage tank and a liquid level sensor to realize the automatic adjustment of the dialysate supply. When the liquid level in the liquid storage tank reaches the set high level, the system automatically switches the liquid supply mode, closes the booster pump, and enables the liquid storage tank to supply liquid. When the liquid level drops to the set low level, the booster pump supply is automatically restored to ensure the continuity and stability of the dialysate supply and realize intelligent liquid level management.

[0026] (4) The blood purification device of an extracorporeal blood circuit provided by the present invention has perfect safety protection measures. A one-way valve is provided to prevent liquid backflow, a blood sampling port is equipped to facilitate the monitoring of the blood state, a temperature regulating element and a temperature sensor are provided to ensure that the temperature of the blood to be transfused is appropriate; a slag discharge pipe is provided at the bottom to facilitate the timely removal of sediments. Description of the Drawings

[0027] Figure 1 is the overall top view of Embodiment 1 of the present invention;

[0028] Figure 2 is the schematic structural view of the arterial end blood vessel I of the present invention;

[0029] Figure 3 is the front view of the blood side of the present invention;

[0030] Figure 4 is the front view of the dialysate side of the present invention;

[0031] Figure 5It is an internal schematic diagram of the dialysate side of the present invention;

[0032] Figure 6 It is a front view of the bypass liquid storage tank of the present invention;

[0033] Figure 7 It is a structural schematic diagram of the airbag part of the present invention;

[0034] Figure 8 Overall top view of Embodiment 2 of the present invention.

[0035] In the figure: 100, arterial end blood vessel one; 101, blood inlet sampling port; 102, first pressure sensor; 200, first peristaltic pump; 300, arterial end blood vessel two; 301, second pressure sensor; 302, first one-way valve; 400, blood side; 410, slag discharge pipe; 411, stop valve; 500, semipermeable membrane; 600, dialysate side; 610, liquid inlet pipe; 611, booster pump; 612, first overflow valve; 620, bypass liquid storage tank; 621, second overflow valve; 622, liquid level sensor; 630, bypass pipeline; 631, first solenoid valve; 632, second one-way valve; 640, liquid discharge pipeline; 641, second solenoid valve; 650, first airbag; 660, second airbag; 670, airbag air inlet pipeline; 671, third solenoid valve; 672, fourth solenoid valve; 680, first airbag exhaust pipeline; 681, fifth solenoid valve; 690, second airbag exhaust pipeline; 691, sixth solenoid valve; 700, venous end blood vessel one; 701, blood outlet sampling port; 702, third pressure sensor; 800, second peristaltic pump; 900, venous end blood vessel two; 901, fourth pressure sensor; 902, temperature regulating element; 903, temperature sensor. Detailed implementation manners

[0036] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0037] It should be noted that the terms "upper", "lower", "left", "right", "top", "bottom", "inner", "outer", etc. indicating the orientation or position relationship are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the components or elements referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus cannot be construed as a limitation to the present invention.

[0038] It should be understood that in the description of the invention, it should be noted that unless otherwise clearly specified and defined, the terms "installed", "connected", and "linked" should be understood in a broad sense.

[0039] Embodiment 1: Refer to the appendix Figures 1 to 7 , a blood purification device for an extracorporeal circulation blood path provided in this Embodiment 1 includes an arterial end blood vessel 100, a first peristaltic pump 200, an arterial end blood vessel 300, a blood treatment unit, a venous end blood vessel 700, a second peristaltic pump 800, a venous end blood vessel 900, and a PLC control system.

[0040] The inlet end of the first peristaltic pump 200 is connected to the arterial end blood vessel 100, and the outlet end of the first peristaltic pump 200 is connected to the arterial end blood vessel 300.

[0041] The inlet end of the second peristaltic pump 800 is connected to the venous end blood vessel 700, and the outlet end of the second peristaltic pump 800 is connected to the venous end blood vessel 900.

[0042] A semipermeable membrane 500 is provided in the center of the blood treatment unit. The blood treatment unit is divided into a blood side 400 and a dialysate side 600 by the semipermeable membrane 500. The arterial end blood vessel 300 is communicated with the blood side 400, and the venous end blood vessel 700 is communicated with the blood side 400.

[0043] On one side of the dialysate side 600 away from the semipermeable membrane 500, a liquid inlet pipe 610 is provided, and a drainage pipe 640 is provided at the bottom of the dialysate side 600.

[0044] Several groups of airbag parts are provided in the dialysate side 600. The airbag part includes a first airbag 650 and a second airbag 660.

[0045] A bypass storage tank 620 is provided outside the dialysate side 600. The rear end of the bypass storage tank 620 is connected to a bypass pipeline 630. The bypass pipeline 630 is communicated with the dialysate side 600. A second overflow valve 621 is provided on one side of the bypass storage tank 620 away from the bypass pipeline 630. A liquid level sensor 622 is provided on the front surface of the bypass storage tank 620. A first electromagnetic valve 631 and a second one-way valve 632 are provided on the bypass pipeline 630.

[0046] Among them, a booster pump 611 is provided on the liquid inlet pipe 610. The dialysate is pumped into the dialysate side 600 through the booster pump 611. A first overflow valve 612 is provided on the bypass of the liquid inlet pipe 610. The first overflow valve 612 is communicated with the bypass storage tank 620. A second electromagnetic valve 641 is provided on the drainage pipe 640.

[0047] It should be noted that during dialysis, the pressure on the blood side 400 should be higher than the pressure on the dialysate side 600. The pressure on the blood side 400 can be precisely controlled by a pressure sensor. However, since a large amount of fresh dialysate is required on the dialysate side, it is easy for the pressure on the dialysate side 600 to fluctuate within a large range. At a certain stage, the pressure on the dialysate side 600 may be higher than the pressure on the blood side 400, affecting the dialysis effect and even potentially causing the dialysis membrane to rupture, leading to serious complications such as patient blood loss or infection.

[0048] It is not difficult to understand that by setting the first overflow valve 612 and the second overflow valve 621, the present invention ensures that the pressure on the dialysate side 600 is always lower than the pressure on the blood side 400. At the same time, the set pressure of the second overflow valve 621 is lower than the set pressure of the first overflow valve 612. When the pressure of the booster pump 611 is higher than the set pressure of the first overflow valve 612, part of the dialysate flows into the bypass liquid storage tank 620 through the first overflow valve 612, thereby ensuring that the pressure value of the dialysate flowing into the dialysate side 600 is maintained within the set range.

[0049] The air inlet end of the first airbag 650 is connected to an airbag air inlet pipeline 670. The airbag air inlet pipeline 670 is a three-way pipeline. The total inlet of the airbag air inlet pipeline 670 is connected to an external air compressor. A one-way valve, a third solenoid valve 671, and a fourth solenoid valve 672 are provided on the airbag air inlet pipeline 670. The fourth solenoid valve 672 is located at the front end of the second airbag 660.

[0050] The rear end of the first airbag 650 is connected to a first airbag exhaust pipeline 680, and the rear end of the second airbag 660 is connected to a second airbag exhaust pipeline 690. Both the first airbag exhaust pipeline 680 and the second airbag exhaust pipeline 690 extend outside the dialysate side 600. A fifth solenoid valve 681 and a one-way valve are provided on the first airbag exhaust pipeline 680, and a sixth solenoid valve 691 and a one-way valve are provided on the second airbag exhaust pipeline 690. During operation, the opening states of the third solenoid valve 671 and the fourth solenoid valve 672 are opposite, the opening states of the third solenoid valve 671 and the sixth solenoid valve 691 are the same, and the opening states of the fourth solenoid valve 672 and the fifth solenoid valve 681 are the same.

[0051] Both the first airbag 650 and the second airbag 660 are fixedly connected to the frame of the blood side 400 through brackets. The first airbag 650 and the second airbag 660 are arranged alternately within the blood side 400, and a change in the dynamic cross-sectional area is formed according to the change in their air intake and exhaust states.

[0052] It is not difficult to understand that when the third solenoid valve 671 is opened, the fourth solenoid valve 672 and the fifth solenoid valve 681 are closed at this time, and at the same time the sixth solenoid valve 682 is opened. At this time, the air compressor inflates the first airbag 650, the volume of the first airbag 650 increases, deflates the second airbag 660, and the volume of the second airbag 660 becomes smaller. After a preset time, the third solenoid valve 671 and the sixth solenoid valve 682 are closed, and the fourth solenoid valve 672 and the fifth solenoid valve 681 are opened. At this time, the air compressor inflates the second airbag 660, the volume of the second airbag 660 increases, deflates the first airbag 650, and the volume of the first airbag 650 becomes smaller; the present invention makes the first airbag 650 and the second airbag 660 perform periodic inflation and deflation, so that the cross-sectional area of the dialysis fluid side 600 changes dynamically. This dynamic change promotes the full mixing of the small molecule toxins that have diffused to the dialysis fluid side 600 with the dialysis fluid, avoiding the local enrichment of small molecule toxins in the area near the semi-permeable membrane 500 to form a dead zone, thereby improving the overall dialysis effect.

[0053] A pipe clamp, a blood inlet sampling port 101 and a first pressure sensor 102 are provided on the arterial end blood vessel one 100, and a second pressure sensor 301 and a first one-way valve 302 are provided on the arterial end blood vessel two 300. The first one-way valve 302 can prevent blood from flowing back.

[0054] A slag discharge pipe 410 is connected to the bottom of the blood side 400, and a stop valve 411 is provided on the slag discharge pipe 410.

[0055] A blood outlet sampling port 701 and a third pressure sensor 702 are provided on the venous end blood vessel one 700, and a fourth pressure sensor 901 is provided on the venous end blood vessel two 900.

[0056] The working process of this Embodiment 1 is as follows: Start the first peristaltic pump 200, transport the blood to be dialyzed in the arterial end blood vessel one 100 connected to the human artery to the arterial end blood vessel two 300, and then flow into the blood side 400 of the blood treatment part. Through the semi-permeable membrane 500, dialysis treatment is carried out with the dialysis fluid. The small molecule toxins in the blood on the blood side 400 will diffuse through the semi-permeable membrane 500 into the dialysis fluid on the dialysis fluid side 600. At the same time, the electrolytes in the dialysis fluid on the dialysis fluid side 600 will enter the blood through the semi-permeable membrane 500. The updated blood flows from the blood side 400 to the venous end blood vessel one 700. Start the second peristaltic pump 800, and the updated blood flows into the human artery connected thereto through the venous end blood vessel two 900.

[0057] Set the overflow pressures of the first overflow valve 612 and the second overflow valve 621 according to the pressure value of the blood in the blood side 400. Start the booster pump 611. Fresh dialysis fluid flows into the dialysis fluid side 600 from the liquid inlet pipe 610. Through the PLC control system, the first airbag 650 and the second airbag 660 are in a periodic inflation and deflation change, resulting in a dynamic change in the cross-sectional area of the dialysis fluid side 600, promoting the mixing of small molecule toxins that have diffused into the dialysis fluid side 600 with the dialysis fluid, and avoiding the concentration of small molecule toxins in the area near the semi-permeable membrane 500, which affects the dialysis effect.

[0058] To ensure the dialysis effect, the pressure of the dialysis fluid side 600 needs to be lower than the pressure of the blood side 400. When the pressure of the booster pump 611 is higher than the set pressure of the first overflow valve 612, part of the dialysis fluid flows into the bypass liquid storage tank 620 through the first overflow valve 612, thus ensuring that the pressure value of the dialysis fluid flowing into the dialysis fluid side 600 is maintained within the set range. When the liquid level of the dialysis fluid in the bypass liquid storage tank 620 reaches the set high level of the liquid level sensor 622, the liquid level sensor 622 feeds back a signal to the PLC control system, opens the first solenoid valve 631 and closes the booster pump 611, and supplies dialysis fluid to the dialysis fluid side 600 through the bypass liquid storage tank 620. When the liquid level of the bypass liquid storage tank 620 drops to the set low level of the liquid level sensor 622, the liquid level sensor 622 feeds back a signal to the PLC control system, closes the first solenoid valve 631 and opens the booster pump 611, and supplies dialysis fluid to the dialysis fluid side 600 through the liquid inlet pipe.

[0059] Embodiment 2: Refer to the appendix Figures 2 to 8 A blood purification device for an extracorporeal circulation blood path provided in this Embodiment 2. Compared with Embodiment 1, this Embodiment 2 includes all the components of Embodiment 1. At the same time, a temperature regulating element 902 and a temperature sensor 903 are also provided on the venous end blood vessel II 900. The temperature regulating element 902 is located at the rear of the fourth pressure sensor 901, and the temperature sensor 903 is located at the rear of the temperature regulating element 902. When the blood dialysis time is relatively long, by setting the temperature regulating element 902 and the temperature sensor 903, it is ensured that the temperature of the blood for reinfusion is appropriate.

[0060] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A blood purification device for an extracorporeal blood circulation circuit, characterized in that: It comprises an arterial end blood vessel 1 (100), a first peristaltic pump (200), an arterial end blood vessel 2 (300), a blood processing unit, a venous end blood vessel 1 (700), a second peristaltic pump (800), a venous end blood vessel 2 (900) and a PLC control system; The inlet end of the first peristaltic pump (200) is connected to the arterial end blood vessel 1 (100), and the outlet end of the first peristaltic pump (200) is connected to the arterial end blood vessel 2 (300); The inlet end of the second peristaltic pump (800) is connected to the venous end blood vessel 1 (700), and the outlet end of the second peristaltic pump (800) is connected to the venous end blood vessel 2 (900); A semipermeable membrane (500) is provided in the center of the blood processing section, and the blood processing section is divided into a blood side (400) and a dialysate side (600) through the semipermeable membrane (500), the arterial end blood vessel 2 (300) is connected to the blood side (400), and the venous end blood vessel 1 (700) is connected to the blood side (400); A liquid inlet pipe (610) is provided on the side of the dialysate side (600) away from the semipermeable membrane (500), and a liquid discharge pipe (640) is provided at the bottom of the dialysate side (600); A plurality of groups of airbag sections are arranged in the dialysate side (600), and the airbag sections include a first airbag (650) and a second airbag (660).

2. The blood purification device for an extracorporeal blood circulation circuit according to claim 1, characterized in that: A bypass liquid storage tank (620) is arranged outside the dialysate side (600), and a bypass pipe (630) is connected to the rear end of the bypass liquid storage tank (620). The bypass pipe (630) is communicated with the dialysate side (600). A second overflow valve (621) is arranged on the side of the bypass liquid storage tank (620) away from the bypass pipe (630), and a liquid level sensor (622) is arranged on the front of the bypass liquid storage tank (620). A first solenoid valve (631) and a second one-way valve (632) are arranged on the bypass pipe (630).

3. The blood purification device for an extracorporeal blood circulation circuit according to claim 2, characterized in that: The liquid inlet pipe (610) is provided with a booster pump (611), and the dialysate is pumped into the dialysate side (600) through the booster pump (611). A first overflow valve (612) is provided on the bypass of the liquid inlet pipe (610), and the first overflow valve (612) is connected to the bypass liquid storage tank (620). The liquid discharge pipe (640) is provided with a second solenoid valve (641).

4. The blood purification device for an extracorporeal blood circulation circuit according to claim 3, characterized in that: The air inlet end of the first airbag (650) is connected to an airbag air inlet pipe (670), and the airbag air inlet pipe (670) is a three-way pipe. The total inlet of the airbag air inlet pipe (670) is connected to an external air compressor. The airbag air inlet pipe (670) is provided with a third solenoid valve (671) and a fourth solenoid valve (672), and the fourth solenoid valve (672) is located at the front end of the second airbag (660).

5. The blood purification device for an extracorporeal blood circulation circuit according to claim 4, characterized in that: The rear end of the first airbag (650) is connected to a first airbag exhaust pipe (680), and the rear end of the second airbag (660) is connected to a second airbag exhaust pipe (690). The first airbag exhaust pipe (680) is provided with a fifth solenoid valve (681), and the second airbag exhaust pipe (690) is provided with a sixth solenoid valve (691). When working, the opening states of the third solenoid valve (671) and the fourth solenoid valve (672) are opposite, the opening states of the third solenoid valve (671) and the sixth solenoid valve (691) are consistent, and the opening states of the fourth solenoid valve (672) and the fifth solenoid valve (681) are consistent.

6. The blood purification device for an extracorporeal blood circulation circuit according to claim 1, characterized in that: The first airbag (650) and the second airbag (660) are both fixedly connected to the frame of the blood side (400) through a bracket, and the first airbag (650) and the second airbag (660) are alternately arranged in the blood side (400).

7. The blood purification device for an extracorporeal blood circulation circuit according to claim 5, characterized in that: The arterial end blood vessel one (100) is provided with a blood sampling port (101) and a first pressure sensor (102), and the arterial end blood vessel two (300) is provided with a second pressure sensor (301) and a first one-way valve (302).

8. The blood purification device for an extracorporeal blood circulation circuit according to claim 1, characterized in that: The bottom of the blood side (400) is connected to a slag discharge pipe (410), and a stop valve (411) is provided on the slag discharge pipe (410).

9. The blood purification device for an extracorporeal blood circulation circuit according to claim 7, characterized in that: The venous end blood vessel one (700) is provided with a bleeding sampling port (701) and a third pressure sensor (702), and the venous end blood vessel two (900) is provided with a fourth pressure sensor (901).

10. The blood purification device for an extracorporeal blood circulation circuit according to claim 9, characterized in that: The second venous end blood vessel (900) is also provided with a temperature regulating element (902) and a temperature sensor (903), wherein the temperature regulating element (902) is located at the rear end of the fourth pressure sensor (901), and the temperature sensor (903) is located at the rear end of the temperature regulating element (902).

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