Detection method and detection system for water concentration in blood

Abstract

The invention provides a detection method and a detection system for water concentration in blood, and belongs to the technical field of blood detection. The system comprises a detection blood chamber, wherein an inlet and an outlet are formed in the two sides of the detection blood chamber respectively; the inlet and the outlet of the detection blood chamber are respectively connected with the flow guide tube; the light source is positioned on one side of the detection blood chamber and is used for directly irradiating the detection blood chamber; the detector is located on the other side of the detection blood chamber and used for receiving the light beams which are emitted by the light source and penetrate through the detection blood chamber. According to the detection system, separated components are adopted, and the light source component and the detector component are long-term fixed equipment and are stable in performance; the detection blood chamber is a disposable measuring device, and the device is simple, can be scrapped after being used by a person once, and is safe, low in cost and simple and convenient to operate.

Description

Technical Field

[0001] The present invention relates to the technical field of blood detection, and particularly to a method and a system for detecting the water concentration in blood. Background Art

[0002] The detection of blood water concentration is crucial in medical treatment and health management. By monitoring the water content in blood, the body fluid balance state of patients can be evaluated, and abnormal conditions such as dehydration or edema can be diagnosed. In intensive care, the detection of blood water concentration helps to guide fluid replacement therapy, ensure the body fluid balance of patients, and avoid damage to organ functions. In addition, it can also be used to monitor kidney function, cardiovascular diseases, and electrolyte disorders. For example, patients with heart failure need to strictly control their body fluid volume, and the detection of blood water concentration can help to adjust the treatment plan. Therefore, the detection of blood water concentration has important value in disease diagnosis, treatment, and prevention.

[0003] Currently, there are various conventional methods in the market and research field. Bioelectrical impedance analysis is a non-invasive method. By applying a small current to different parts of the human body and based on the changes when the current passes through human tissues (including water, fat, muscle, etc.), the ratio of intracellular fluid to extracellular fluid can be measured. This method can evaluate the water concentration of blood and other body fluids to a certain extent and is commonly used to evaluate the body fluid balance state, especially in patients with chronic diseases.

[0004] Water-specific nuclear magnetic resonance technology can provide detailed information on the water distribution in the body, including the water content in blood. The advantage of this technology is that it can distinguish intracellular water from extracellular water and has important value for studying water regulation at the cellular level. However, NMR equipment is expensive and its application is relatively limited.

[0005] The change in the water concentration in blood will affect the conductivity of serum. Therefore, by measuring the change in serum conductivity, the change in blood water concentration can be indirectly reflected. This method is simple and fast, but requires accurate calibration and may be affected by the concentration of other ions in blood. Plasma osmotic pressure is a direct indicator of blood water concentration.

[0006] Osmotic pressure reflects the number of particles (such as sodium ions, glucose, and urea, etc.) in a solution, and the number of these particles is inversely proportional to the water content in blood. By measuring plasma osmotic pressure, the blood water concentration can be accurately evaluated. The equipment cost is relatively high, and professional operation is required with high requirements for sample preservation conditions.

[0007] Raman spectroscopy can be used to non-invasively detect the content of water and other molecules in blood. By analyzing the light reflected from the sample, this method can provide detailed chemical composition information. Raman spectroscopy technology has high specificity and sensitivity in liquid detection, but its equipment cost is relatively high and requires professional operation.

[0008] With the development of science and technology and the rapidly increasing demand for medical care, it is of great practical significance to provide a blood water concentration monitoring system and method that is more cost-effective, more convenient and effective. Summary of the Invention

[0009] The purpose of the present invention is to provide a detection system for the water concentration in blood, aiming to solve the technical problems of high cost and complex operation in the existing blood water concentration detection methods.

[0010] In order to achieve the above-mentioned invention purpose, the present invention provides the following technical solutions:

[0011] The present invention provides a detection system for the water concentration in blood, including:

[0012] A detection blood chamber, with an inlet and an outlet respectively provided on both sides of the detection blood chamber;

[0013] A diversion tube, with the inlet and outlet of the detection blood chamber respectively connected to the diversion tube;

[0014] A light source, located on one side of the detection blood chamber, for directly irradiating the detection blood chamber;

[0015] A detector, located on the other side of the detection blood chamber, for receiving the light beam emitted by the light source after passing through the detection blood chamber.

[0016] Preferably, the detection system further includes:

[0017] A mirror assembly, the mirror assembly includes two mirrors.

[0018] Preferably, the detection blood chamber is made of a transparent material.

[0019] Preferably, the light source can emit at least one stable light beam.

[0020] Preferably, a needle penetrating the blood vessel is provided on one side of the diversion tube.

[0021] The present invention also provides a detection method for the water concentration in blood, and the detection method uses the detection system described in the above technical solution.

[0022] Preferably, it includes the following steps:

[0023] The blood is drawn from the blood vessel by using the diversion tube, enters the detection blood chamber through the inlet of the detection blood chamber, and then flows back to the blood vessel through the outlet of the detection blood chamber;

[0024] When the blood flows through the detection blood chamber, the light source emits a light beam to irradiate the detection blood chamber, and the detector receives the light beam emitted by the light source.

[0025] Preferably, the calculation formula for the energy of the light beam received by the detector is:

[0026] I = I 0 *(T 1 *T 2i ) n ,

[0027] wherein, I 0 is the spot energy of the light beam just emitted by the light source;

[0028] T 1 is the transmittance of the monitoring blood chamber based on a single transmission of the measurement light source;

[0029] T 2i is the transmittance of the blood to the single transmission of the measurement light source at the i-th time point;

[0030] n is the number of times the measurement light source penetrates the monitoring blood chamber when it reaches the detector;

[0031] I 0 , T 1 can be obtained through pre-calibration (when the blood vessel is not connected and blood flows in), I is directly obtained during detector monitoring, and n is the number of times the beam penetrates the monitoring blood chamber multiple times caused by adjusting the mirror during actual testing.

[0032] Compared with the prior art, the technical solution of the present invention has the following beneficial effects:

[0033] (1) The present invention adopts a separated light source component, a detector component and a detection blood chamber component. Among them, the light source component and the detector component are long-term fixed devices with stable performance, which can well ensure the accuracy of measurement;

[0034] (2) In the detection system of the present invention, the detection blood chamber is a disposable measurement device, which is simple in structure, and can be discarded after one personal use, which is safe and low in cost;

[0035] (3) The measurement principle of the detection system of the present invention is optical non-contact measurement, and other devices are not easily contaminated by the blood of the user;

[0036] (4) The detection system of the present invention can replace different light source components or simultaneously adopt multiple light source components. The detector can obtain light spots with different energy attenuation degrees, which can relatively improve the detection accuracy;

[0037] (5) The detection system of the present invention also realizes multiple absorptions of the measurement beam in the monitoring blood chamber by setting a mirror or adjusting the angle of the mirror, so as to adjust the attenuation of the beam, and can quickly adapt to the detection of blood water concentration at different levels;

[0038] (6) The detection system of the present invention can accurately obtain relatively accurate water concentration data of individuals or the whole by establishing a large database. Description of the Drawings

[0039] Figures 1 to 3 It is a schematic diagram of the detection system of the present invention. Detailed Embodiments

[0040] The present invention provides a detection system for the water concentration in blood, including:

[0041] A detection blood chamber, with an inlet and an outlet respectively arranged on both sides of the detection blood chamber;

[0042] A diversion tube, with the inlet and the outlet of the detection blood chamber respectively connected to the diversion tube;

[0043] A light source, located on one side of the detection blood chamber, for directly irradiating the detection blood chamber;

[0044] A detector, located on the other side of the detection blood chamber, for receiving the beam that passes through the detection blood chamber and is emitted by the light source.

[0045] The implementation principle of the detection system of the present invention is as follows: Since the water content in blood is relatively large, by selecting a spectral light source that is easily absorbed by water, it penetrates the blood in the monitoring blood chamber. After being absorbed by the water in the blood, the transmittance of the beam decreases. The detector obtains and analyzes the spot image, and calculates the change in the water concentration in the blood by calculating the change in the spot intensity at different times through the change in the transmittance.

[0046] In the present invention, the detection system further includes:

[0047] A mirror assembly, which includes two mirrors.

[0048] In the present invention, when the detection system includes a mirror assembly, the detector and the light source are arranged on the same side of the monitoring blood chamber, and the mirror assembly is set to transmit the light emitted by the light source through the monitoring blood chamber and reflect it into the detector, and the included angle between the two mirrors can be adjusted to achieve the beam passing through the monitoring blood chamber more than once and entering the detector, and then the change in the spot light intensity is detected through image processing;

[0049] In the present invention, the detection blood chamber is made of a transparent material.

[0050] In the present invention, the light source can emit at least one stable light beam.

[0051] In the present invention, a needle penetrating the blood vessel is provided on one side of the diversion tube.

[0052] In the present invention, a needle is provided on one side of the diversion tube, and blood can be driven by blood pressure to flow into the diversion tube.

[0053] The present invention also provides a method for detecting the water concentration in blood, and the detection method uses the detection system described in the above technical solution.

[0054] Further, it includes the following steps:

[0055] Use the diversion tube to draw blood out of the blood vessel, enter the detection blood chamber through the inlet of the detection blood chamber, and then flow back to the blood vessel through the outlet of the detection blood chamber;

[0056] When the blood flows through the detection blood chamber, the light source emits a light beam to irradiate the detection blood chamber, and the detector receives the light beam emitted by the light source.

[0057] Further, the calculation formula for the energy of the light beam received by the detector is:

[0058] I = I 0 *(T 1 *T 2i ) n ,

[0059] wherein, I 0 is the spot energy of the light beam just emitted by the light source;

[0060] T 1 is the transmittance of the monitoring blood chamber based on a single transmission of the measurement light source;

[0061] T 2i is the transmittance of the blood to the single transmission of the measurement light source at the i-th time point;

[0062] n is the number of times the measurement light source penetrates the monitoring blood chamber when it reaches the detector;

[0063] I 0 , T 1 can be obtained through pre-calibration (without connecting the blood vessel and flowing in blood), I is directly obtained during detector monitoring, and n is the number of times the actual test adjusts the mirror to cause the light beam to penetrate the monitoring blood chamber multiple times.

[0064] In the present invention, unless otherwise specified, the raw materials required for preparation are all commercially available products well-known to those skilled in the art.

[0065] The technical solution provided by the present invention will be described in detail below in conjunction with embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0066] Embodiment 1

[0067] Blood is drawn from a blood vessel using a diversion tube. The blood enters the detection blood chamber through the inlet of the detection blood chamber and then flows back into the blood vessel through the outlet of the detection blood chamber. When the blood flows through the detection blood chamber, a light source emits a light beam to irradiate the detection blood chamber, and a detector receives the light beam emitted by the light source.

[0068] Among them, the calculation formula for the energy of the light beam received by the detector is:

[0069] I = I 0 *(T 1 *T 2i ) n ,

[0070] Among them, I 0 is the spot energy of the light beam just emitted by the light source;

[0071] T 1 is the transmittance of the monitoring blood chamber based on a single transmission of the measurement light source;

[0072] T 2i is the transmittance of the blood to the single transmission of the measurement light source at the i-th time point;

[0073] n is the number of times the measurement light source penetrates the monitoring blood chamber when it reaches the detector;

[0074] I 0 , T 1 can be obtained through pre-calibration (when the blood vessel is not connected and blood flows in), I is directly obtained during detector monitoring, and n is the number of times the light beam penetrates the monitoring blood chamber multiple times caused by adjusting the mirror during actual testing;

[0075] After the light beam emitted by the light source is absorbed by the water in the blood, the transmittance decreases. The detector obtains and analyzes the spot image, and calculates the change in the water concentration in the blood by calculating the change in the spot intensity at different times through the change in the transmittance.

[0076] The above is only the preferred embodiment of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. A system for detecting water concentration in blood, characterized in that: include: A blood testing chamber, wherein an inlet and an outlet are respectively provided on two sides of the blood testing chamber; A flow guide tube, the inlet and the outlet of the blood detection chamber are respectively connected to the flow guide tube; A light source, the light source is located at one side of the detection blood chamber and is used to directly illuminate the detection blood chamber; The detector is located at the other side of the detection blood chamber and is used to receive the light beam emitted by the light source and passing through the detection blood chamber.

2. The blood water concentration detection system according to claim 1, characterized in that: The detection system also includes: A reflector assembly comprises two reflectors.

3. The blood water concentration detection system according to claim 1, characterized in that: The blood detection chamber is made of transparent material.

4. The blood water concentration detection system according to claim 1, characterized in that: The light source can emit at least one stable light beam.

5. The blood water concentration detection system according to claim 1, characterized in that: A needle for penetrating a blood vessel is arranged on one side of the guide tube.

6. A method for detecting water concentration in blood, characterized in that: The detection method adopts the detection system according to any one of claims 1 to 5.

7. The method for detecting water concentration in blood according to claim 6, characterized in that: The following steps are involved: The blood is guided out of the blood vessel by the guide tube, enters the detection blood chamber through the inlet of the detection blood chamber, and then flows back to the blood vessel through the outlet of the detection blood chamber; When blood flows through the detection blood chamber, the light source emits a light beam to illuminate the detection blood chamber, and the detector receives the light beam emitted by the light source.

8. The method for detecting water concentration in blood according to claim 6, characterized in that: The calculation formula of the beam energy received by the detector is: I=I0*(T1*T 2i ) n , Among them, I0 is the spot energy of the light beam just emitted by the light source; T1 is the transmittance of the blood chamber based on the measurement of the light source's one-time transmission; T 2i is the transmittance of blood to the measurement light source at time point i; n is the number of times the measuring light source penetrates the monitoring blood chamber when reaching the detector; I0 and T1 can be obtained by pre-calibration (blood vessels are not connected and blood flows in), I is directly obtained during detector monitoring, and n is the number of times the light beam penetrates the monitoring blood chamber multiple times caused by adjusting the reflector during actual testing.

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