Kidney essence regeneration and repair composition and preparation method thereof

Abstract

The invention discloses a composition and a preparation method thereof, and particularly relates to a kidney essence regeneration and repair composition and a preparation method thereof. 30 parts of fructus lycii; 15 parts of pilose antler; 25 parts of rhizoma polygonati; 20 parts of herba epimedii; 15 parts of Chinese yam; 10 parts of Chinese angelica; 20 parts of eucommia ulmoides; 15 parts of morinda officinalis; 10 parts of herba epimedii; 10 parts of dendrobium nobile; 20 parts of radix astragali; and 15 parts of semen cuscutae. Traditional herbal extraction mostly adopts single-time water decoction or alcohol extraction, raw materials are grouped according to efficacy, a multi-stage extraction process is adopted, water-soluble, polysaccharide, flavonoid, saponin, fat-soluble and other active ingredients are gradually released according to physicochemical characteristics of different ingredients, the medicine effect is reserved to the maximum extent, and the ingredient extraction rate and purity are improved.

Description

Technical Field

[0001] The present invention relates to the field of pharmaceutical technology, and particularly relates to a composition for regenerating and repairing kidney essence and a preparation method thereof. Background Art

[0002] Health problems such as kidney essence deficiency and decreased kidney function are manifested as phenomena such as physical decline, low immunity, premature aging, endocrine disorders, and reduced reproductive ability. Most of the existing kidney-tonifying products on the market adopt simple water decoction or alcohol extraction processes of traditional Chinese medicinal materials, with low extraction rate, insufficient active ingredients, and relatively single compatibility, unable to take into account multiple effects such as tonifying the kidney, nourishing essence, and regulating qi and blood. At the same time, some key active ingredients are difficult to be efficiently absorbed and utilized due to strong thermosensitivity and poor liposolubility, affecting the final curative effect. Therefore, developing a composition for regenerating and repairing kidney essence with high-efficiency extraction and scientific compatibility has become the technical breakthrough direction for solving kidney essence deficiency and related health problems. Summary of the Invention

[0003] In order to solve the problems existing in the above-mentioned prior art, the present invention provides a composition for regenerating and repairing kidney essence and a preparation method thereof to solve the current technical problems.

[0004] The technical solution adopted by the present invention to solve its technical problems is as follows: The present invention provides a composition for regenerating and repairing kidney essence and a preparation method thereof, including: Ginseng: 25 parts; Chinese wolfberry: 30 parts; Pilose antler: 15 parts; Polygonatum sibiricum: 25 parts; Epimedium brevicornum: 20 parts; Chinese yam: 15 parts; Angelica sinensis: 10 parts; Eucommia ulmoides: 20 parts; Morinda officinalis: 15 parts; Epimedium: 10 parts; Dendrobium officinale: 10 parts; Astragalus membranaceus: 20 parts; Cuscuta chinensis: 15 parts.

[0005] Preferably, it further includes several excipients: Honey: 30 parts; Maltodextrin: 20 parts; Licorice powder: 5 parts.

[0006] Preferably, it includes the following preparation process: Step1: Raw material pretreatment step; Step2: Extraction step; Step3: Composition preparation step.

[0007] Preferably, the Step1: Raw material pretreatment step includes: Cleaning and pretreatment: Each herbal raw material is cleaned thoroughly, impurities are removed, and it is drained; Pilose antler is soaked in warm water at 40°C until soft and then sliced. Drying and pulverizing: The herbal raw materials and the sliced pilose antler are dried until the moisture content ≤ 10%; and coarsely pulverized to more than 60 meshes with a pulverizer.

[0008] Preferably, the Step2: Extraction step includes raw material grouping, Group 1: Ginseng, Chinese wolfberry, polygonatum sibiricum, Chinese yam, angelica sinensis; Group 2: Pilose antler, epimedium brevicornum, morinda officinalis, epimedium, eucommia ulmoides; Group 3: Dendrobium officinale, astragalus membranaceus, cuscuta chinensis, liquorice.

[0009] Preferably, the Step 3: Composition preparation step includes: Mixing: Add 30 g of honey, 20 g of maltodextrin, and 5 g of liquorice powder to the powder obtained from the extraction step and mix them; Fine stirring: Stir for 20 minutes to ensure that the raw materials are evenly mixed and the materials are completely fused into a delicate paste.

[0010] The beneficial effects of the present invention are: Multi-stage fine extraction process: Traditional herbal extractions are mostly single-time water decoction or alcohol extraction. In the present invention, the raw materials are grouped according to their effects and a multi-stage extraction process is adopted. According to the physical and chemical properties of different components, water-soluble, polysaccharide, flavonoid, saponin, fat-soluble and other active components are gradually released, maximizing the retention of medicinal effects, and improving the extraction rate and purity of components.

[0011] Grouped extraction and combined compatibility: Extraction is carried out in three major groups according to the effects of nourishing group, kidney-tonifying and yang-strengthening group, and qi and blood conditioning group, retaining the best active state of each component. Then, they are compounded into a composition according to a scientific ratio, forming a synergistic complementarity of the triple effects of tonifying the kidney, nourishing essence, and regulating qi and blood, comprehensively promoting the regeneration of kidney essence and the repair of the body, breaking through the limitations of single medicinal effects, and improving the overall curative effect.

[0012] Low-temperature protection and membrane separation and purification: Low-temperature freezing treatment and 500 Dalton membrane separation technology are adopted to retain the small-molecule active essence and remove the macromolecular impurities, ensuring high purity and high activity of the final product, avoiding the destruction of thermosensitive active components by high temperature, improving the stability and absorption rate of the preparation, and ensuring a long-term effect.

[0013] Optimization of excipients to improve taste and absorption rate: Combining honey, maltodextrin, and liquorice powder as excipients not only improves the taste, but also has the functions of protecting active components and preventing oxidation. At the same time, it enhances the absorption and utilization of effective components by the stomach and intestines, further improving the compliance of taking and the curative effect performance. Brief Description of the Drawings

[0014] The above aspects and advantages of the present invention will become obvious and easy to understand from the description of the embodiments in conjunction with the following drawings, where: Figure 1 is a schematic diagram of the composition for kidney essence regeneration and repair and its preparation method according to the embodiment of the present invention. Detailed Embodiments

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0016] The present invention provides a composition for kidney essence regeneration and repair and its preparation method, including the following components and preparation process: Components Main ingredients: Ginseng: 25 parts; Chinese wolfberry: 30 parts; Pilose antler: 15 parts; Polygonatum sibiricum: 25 parts; Epimedium brevicornum: 20 parts; Chinese yam: 15 parts; Angelica sinensis: 10 parts; Eucommia ulmoides: 20 parts; Morinda officinalis: 15 parts; Epimedium: 10 parts; Dendrobium officinale: 10 parts; Astragalus membranaceus: 20 parts; Cuscuta chinensis: 15 parts.

[0017] Auxiliary materials: Honey: 30 parts; Maltodextrin: 20 parts; Licorice powder: 5 parts.

[0018] Preparation process Raw material pretreatment step: Cleaning and pretreatment: Each herbal raw material is cleaned thoroughly, impurities are removed, and then drained. Pilose antler needs to be soaked in warm water at 40°C until softened and then sliced for standby.

[0019] Drying and pulverizing: The herbal raw materials are dried to a moisture content ≤ 10% (low-temperature drying at 50°C - 60°C for more than 4 hours), and coarsely pulverized by a pulverizer to 60 meshes or more. Pilose antler needs to be pulverized separately into extremely fine powder, 100 meshes or more.

[0020] Extraction step: Raw material grouping: The first group (tonifying group): Ginseng, Chinese wolfberry, Polygonatum sibiricum, Chinese yam, Angelica sinensis; The second group (kidney-tonifying and yang-strengthening group): Pilose antler, Epimedium brevicornum, Morinda officinalis, Epimedium, Eucommia ulmoides; The third group (qi and blood conditioning group): Dendrobium officinale, Astragalus membranaceus, Cuscuta chinensis, Licorice.

[0021] Multi-stage extraction process: Extraction of the first group: Pretreatment soaking: 120 g of the raw materials in the first group are added with 8 times purified water (960 ml), and left to stand and soak at room temperature for 12 hours to fully expand the cells, soften the cell walls, and promote the dissolution of active ingredients.

[0022] Warming extraction: Phase 1: Heat to 60°C and stir for extraction for 1 hour. This temperature can activate the release of components such as water-soluble polysaccharides and saponins, and avoid damage by high temperature. Phase 2: Raise the temperature to 85°C and continue extraction for 1.5 hours. Further promote the dissolution of heat-resistant active components such as flavonoids and glycosides. Phase 3: Cool down to 75°C and perform ultrasonic-assisted extraction (40kHz) for 30 minutes. In this phase, ultrasonic vibration is used to break the cell wall and improve the release efficiency of the remaining components inside plant cells.

[0023] Cooling and standing: Cool to room temperature and stand for 4 hours to allow large-particle impurities to settle naturally, reducing the subsequent filtration burden.

[0024] Centrifugal separation: Centrifuge at 4000rpm for 15 minutes to further remove coarse residues and improve the purity of the extract.

[0025] Second group extraction: Alcohol extraction process: Add the second group of raw materials in proportion, add 150ml of 60% ethanol, and soak at room temperature for 24 hours. Ethanol helps dissolve lipophilic components such as sterols, terpenoids, and positive activation substances.

[0026] Ultrasonic oscillation: Perform ultrasonic oscillation at 40kHz for 45 minutes, cool for 10 minutes, and repeat 3 times. High-frequency oscillation breaks the cell wall and accelerates the precipitation of components.

[0027] Reflux extraction: Phase 1: Heat to 65°C and reflux for 2 hours to extract mild lipophilic components. Phase 2: Cool to 40°C and stand for 1 hour to retain heat-sensitive components and reduce volatilization loss. Phase 3: Heat to 70°C again and reflux for 1.5 hours to strengthen the extraction of unextracted active components.

[0028] Fine filtration: Filter the coarse residues, fine residues, and precipitates successively through multiple filter meshes to extract the effective liquid part and ensure clarity and purity.

[0029] High-pressure homogenization: Perform high-pressure homogenization at 80MPa twice to refine the lipophilic component particles and improve the component uniformity and bioavailability.

[0030] Third group extraction: Low-temperature extraction: Add the third group of raw materials in proportion, 960ml of pure water; soak at 40°C for 8 hours to protect polysaccharide and flavonoid active components that are easily damaged by high temperature.

[0031] Heating extraction at elevated temperature: Phase 1: Heat to 55°C and extract for 1 hour to promote the precipitation of water-soluble components. Phase 2: Raise the temperature to 70°C and continue stirring for extraction for 1 hour to release medium-temperature heat-resistant components such as glycosides and alkaline components. Phase 3: Raise the temperature to 90°C again and finally extract for 45 minutes to extract high-temperature tolerant components such as polyphenols and saponins.

[0032] Membrane separation and purification: Filter and purify using a 500 Dalton membrane to retain small molecule active essence, remove macromolecular impurities, and increase the concentration of the essence liquid.

[0033] Combination and concentration of the extract: Combine the extracts: Mix the extracts from the first group, second group, and third group, and stir evenly.

[0034] Concentration under reduced pressure: Evaporate and concentrate at 60°C under reduced pressure to 1 / 5 of the original volume of the stock solution. Concentrate at low temperature to avoid destroying thermosensitive active ingredients at high temperature and retain high-concentration active ingredients.

[0035] Static settling at low temperature: Let it stand at room temperature for 12 hours, filter the precipitate to ensure that the extract is clear and pure.

[0036] Freezing and micronization: Freezing treatment: Freeze at -20°C for 3 hours to prevent the crystallization of intracellular water from damaging the structure of active ingredients. Ultrafine grinding: Grind into powder with a 200-mesh ultrafine grinder for easy absorption by the human body.

[0037] Steps for preparing the composition: Mixing: Add 30 g of honey, 20 g of maltodextrin, and 5 g of licorice powder to the powder obtained in the extraction step and mix. Fine stirring: Stir for 20 minutes to ensure that the raw materials are evenly mixed and the materials are completely fused into a delicate paste.

[0038] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A composition for regenerating and repairing kidney essence and a preparation method thereof, characterized in that: include: Ginseng: 25 parts; Wolfberry: 30 servings; Deer antler: 15 parts; Polygonatum sibiricum: 25 parts; Epimedium: 20 parts; Chinese Yam: 15 servings; Angelica: 10 parts; Eucommia: 20 parts; Morinda officinalis: 15 parts; Epimedium: 10 parts; Dendrobium: 10 parts; Astragalus: 20 parts; Cuscuta australis: 15 parts.

2. The composition for regeneration and repair of kidney essence and its preparation method according to claim 1, characterized in that: It also includes several auxiliary materials: honey: 30 parts; maltodextrin: 20 parts; licorice powder: 5 parts.

3. The composition for regeneration and repair of kidney essence and its preparation method according to claim 1, characterized in that: The preparation process includes the following: Step 1: Raw material pretreatment step; Step 2: extraction step; Step 3: composition preparation step.

4. The composition for regeneration and repair of kidney essence and its preparation method according to claim 3, characterized in that: The step 1: raw material pretreatment step includes: Cleaning and pretreatment: Clean the herbal materials one by one and drain them; soak the antlers in 40°C warm water and slice them; Drying and crushing: Dry the herbal raw materials and antler slices until the moisture content is ≤10%; use a crusher to coarsely crush to above 60 mesh.

5. The composition for regeneration and repair of kidney essence and its preparation method according to claim 3, characterized in that: The Step 2: extraction step includes grouping the raw materials, Group 1: Ginseng, wolfberry, polygonatum, yam, and angelica; The second group: velvet antler, epimedium, Morinda officinalis, epimedium, and Eucommia ulmoides; The third group: Dendrobium, Astragalus, Cuscuta, and Licorice.

6. The composition for regeneration and repair of kidney essence and its preparation method according to claim 3, characterized in that: The step 3: the composition preparation step comprises: Mixing: add 30g honey, 20g maltodextrin and 5g licorice powder to the powder obtained in the extraction step; Fine stirring: Stir for 20 minutes to ensure that the raw materials are evenly mixed and the materials are completely integrated into a fine paste.

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