A method for generating monodisperse aerosols of different particle sizes for inhalation by humans

Abstract

The application relates to the field of intelligent medical treatment, in particular to a method for generating hydrophilic monodisperse aerosols with different particle sizes for human inhalation. The method comprises the following steps: obtaining a hydrophilic aerosol generating liquid; and conveying the hydrophilic aerosol generating liquid to an aerosol generator to obtain first monodisperse hydrophilic aerosols. The aerosol generator comprises a polydisperse aerosol generator and an aerosol particle size sorting instrument. The hydrophilic aerosol generating liquid is used to generate polydisperse hydrophilic aerosols through the polydisperse aerosol generator. The polydisperse hydrophilic aerosols are filtered through the aerosol particle size sorting instrument to obtain first monodisperse hydrophilic aerosols with different particle sizes. The method can obtain radioactive hydrophilic monodisperse aerosols with good research value.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of intelligent medical treatment, in particular to a method and device for generating monodisperse hydrophilic aerosols with different particle sizes for human inhalation, a program product and a computer-readable storage medium. BACKGROUND

[0002] Most drugs are hydrophilic particles. However, most of the existing inhalation research of human targeted drugs adopts inhalable polydisperse non-radioactive hydrophobic aerosol generation technology, and there is no reliable human radioactive aerosol closed inhalation device, so it is impossible to obtain reliable high-resolution targeted drug deposition distribution quantification similar to drugs. In 2007, Jakob used an atomization device to first study the total deposition rate of nanoscale (50-150 nm) polydisperse hydrophobic particles in the respiratory tract. The study found that as the particle size increases, the total deposition rate of the particles gradually decreases. In 2017, Rissler et al. first used a polydisperse aerosol generation device to roughly quantitatively study the total deposition rate of polydisperse hydrophobic particles in the respiratory tract in the particle size range of 15-5000 nm. The study found that the total deposition rate of particles in the size range of 15-300 nm gradually decreases as the particle size increases; the total deposition rate of particles in the size range of 300-5000 nm gradually increases as the particle size increases. The above studies can only obtain the total deposition rate of polydisperse hydrophobic aerosol particles, so they cannot obtain the deposition distribution characteristics of each region of the respiratory tract, and have limited guiding significance for the existing clinical drug targeted treatment. SUMMARY

[0003] In view of the above problems, the present application provides a method for generating monodisperse hydrophilic aerosols with different particle sizes for human inhalation, which specifically comprises:

[0004] obtaining a hydrophilic aerosol generating liquid;

[0005] feeding the hydrophilic aerosol generating liquid into an aerosol generator to obtain first monodisperse hydrophilic aerosols; the aerosol generator comprises a polydisperse aerosol generator and an aerosol aerodynamic particle sizer. The hydrophilic aerosol generating liquid is used to generate polydisperse hydrophilic aerosols through the polydisperse aerosol generator, and the polydisperse hydrophilic aerosols are screened to obtain first monodisperse hydrophilic aerosols with different particle sizes through the aerosol particle sizer.

[0006] The first monodisperse hydrophilic aerosols with different particle sizes are monodisperse hydrophilic aerosols with different particle sizes less than or equal to 3 μm.

[0007] Optionally, the aerosol generator further comprises a monodisperse aerosol generator, which is in a parallel relationship without interference with the polydisperse aerosol generator, and the hydrophilic aerosol generating liquid is used to obtain second monodisperse hydrophilic aerosols through the monodisperse aerosol generator.

[0008] Optionally, the second monodisperse aerosol is a monodisperse hydrophilic aerosol with a particle size greater than 3 microns.

[0009] Optionally, the aerosol generator further comprises a medical nebulizer, the medical nebulizer being in parallel relationship with the polydisperse aerosol generator and the monodisperse aerosol generator, and the hydrophilic aerosol generating liquid is converted into a polydisperse hydrophilic aerosol by the medical nebulizer.

[0010] The hydrophilic aerosol generating liquid is a radioactive hydrophilic aerosol generating liquid; the radioactive hydrophilic aerosol generating liquid is fed into the aerosol generator to obtain a first monodisperse radioactive hydrophilic aerosol.

[0011] Optionally, the preparation process of the radioactive hydrophilic aerosol generating liquid is as follows:

[0012] Obtaining a radioisotope and a hydrophilic particle;

[0013] Adding the radioisotope to ultrapure water to obtain a mixed solution;

[0014] Adding the hydrophilic particle to the mixed solution, oscillating and ultrasonicating to obtain a radioactive hydrophilic aerosol generating liquid.

[0015] Optionally, the radioisotope includes 18 F-FDG solution.

[0016] Optionally, the hydrophilic particle includes glucose.

[0017] Optionally, the ultrasonicating is performed for 8-12 minutes.

[0018] The present application aims to provide a method for quantitatively determining the deposition distribution of a hydrophilic aerosol in the respiratory tract, comprising: obtaining a radioactive hydrophilic aerosol according to the above-mentioned method for generating a hydrophilic monodisperse aerosol with different particle sizes for human inhalation, the hydrophilic aerosol comprising one or more of the following: a first monodisperse hydrophilic aerosol, a second monodisperse hydrophilic aerosol, and a polydisperse hydrophilic aerosol.

[0019] After the subject inhales the hydrophilic aerosol, tomography is performed on the respiratory tract of the subject to obtain image data of the subject; and based on the image data of the subject, a deposition distribution map of the hydrophilic aerosol in the respiratory tract is obtained.

[0020] The method further comprises exhaust gas recovery, wherein after the subject inhales the hydrophilic aerosol from the inhalation tower, the remaining radioactive hydrophilic aerosol in the inhalation tower and the exhalation tower is recovered.

[0021] The purpose of this invention is to provide a method for constructing a prediction model for the deposition distribution of hydrophilic particles, comprising: obtaining a deposition distribution dataset of the subject based on the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described above, with hydrophilic aerosols of different particle sizes as labels;

[0022] The dataset and labels are fed into a neural network for training until the loss function remains unchanged, thus obtaining a deposition prediction model.

[0023] The purpose of this invention is to provide a method for predicting the deposition distribution of hydrophilic aerosol particles of different sizes, comprising:

[0024] Obtain the particle size of the hydrophilic aerosol inhaled by the test subject;

[0025] The particle size is input into the sedimentation prediction model obtained by the above-mentioned sedimentation prediction model construction method based on hydrophilic particle sedimentation distribution to obtain a sedimentation distribution prediction map.

[0026] The purpose of this invention is to provide a computer program product comprising a computer program or instructions, wherein the computer program or instructions are executed by a processor to implement the above-described method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above-described method for predicting the deposition distribution of hydrophilic aerosols in the respiratory tract, or to implement the above-described method for constructing a prediction model based on the deposition distribution of hydrophilic particles, or to implement the above-described method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0027] The purpose of this invention is to provide a computer device comprising a memory, a processor, and a computer program or instructions stored in the memory. The computer program or instructions are executed by the processor to implement the above-described method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above-described method for quantitatively determining the deposition distribution of hydrophilic aerosols in the respiratory tract, or to implement the above-described method for constructing a predictive model for the deposition distribution of hydrophilic particles, or to implement the above-described method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0028] The purpose of this invention is to provide a computer-readable storage medium storing a computer program or instructions, wherein the computer program or instructions are executed by a processor to implement the above-described method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, or to implement the above-described method for generating a deposition distribution map of hydrophilic aerosols in the respiratory tract, or to implement the above-described method for constructing a prediction model for the deposition distribution of hydrophilic particles, or to implement the above-described method for predicting the deposition distribution of hydrophilic aerosol particles of different particle sizes.

[0029] Advantages of this invention:

[0030] 1. The aerosol generated by the aerosol generating device for human inhalation is non-radioactive polydisperse, and most of the particles are hydrophobic, and there is no reliable radioactive closed inhalation device, which cannot meet the high-resolution real-time quantification of hydrophilic aerosol particles in the respiratory tract. The present application provides a method for generating hydrophilic aerosol monodisperse, which is helpful for observing the deposition distribution of monodisperse in the human respiratory tract, and further helps to understand the deposition distribution of hydrophilic monodisperse aerosol in the human respiratory tract, and provides research basis for subsequent diagnosis and treatment. Precise targeted drug delivery requires accurate deposition of drugs at the lesion site and reduces drug deposition in healthy areas to minimize damage to the body. The deposition distribution of aerosols of different particle sizes is significantly different. The generation of monodisperse aerosols can obtain the deposition distribution of particles of different particle sizes, and can obtain the difference in deposition mechanism of particles of different particle sizes. However, polydispersion contains multiple particle sizes, and the deposition area is wide, which cannot achieve precise targeted drug delivery.

[0031] 2. The aerosol generating method of the present application can adjust the particles of different particle sizes to provide conditions for the deposition distribution of particles of different particle sizes in the human respiratory tract, and help to understand the deposition trajectory and rule of particles of different particle sizes, and provide help for the positioning of harmful substances in the respiratory tract and the targeted treatment of aerosol drugs. Compared with the existing human inhalation aerosol generation, the present application can generate monodisperse and polydisperse radioactive glucose, which can realize accurate analysis of the deposition difference of aerosols of different particle sizes in the respiratory tract. At the same time, the human inhalation exposure device designed in the present research can not only realize aerosol inhalation without leakage, but also accurately obtain the total deposition rate of the respiratory tract.

[0032] 3. In order to present the distribution of hydrophilic monodisperse aerosol particles of different particle sizes in the respiratory tract, the present application provides a hydrophilic aerosol with radioactivity, which is prepared by ultrasonicating radioactive isotopes with hydrophilic particles to improve the preparation efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0034] Figure 1 The different particle size hydrophilic monodisperse aerosol generation method for human inhalation provided by the embodiment of the present application is shown in the flowchart;

[0035] Figure 2 The different particle size hydrophilic monodisperse aerosol generation system for human inhalation provided by the embodiment of the present application is shown in the schematic diagram;

[0036] Figure 3 A schematic diagram of a hydrophilic monodisperse aerosol generating device for human inhalation is provided for the embodiments of the present application.

[0037] Figure 4 A radioactive hydrophilic aerosol preparation process is provided for the embodiments of the present application; a radioactive glucose aerosol generating liquid with different concentrations is prepared.

[0038] Figure 5 A monodisperse / multidisperse hydrophilic aerosol generating process is provided for the embodiments of the present application; a monodisperse and multidisperse radioactive glucose aerosol generating system.

[0039] Figure 6 An aerosol particle size spectrum is provided for the embodiments of the present application; a 0.7 μm and 3 μm monodisperse aerosol particle size spectrum.

[0040] Figure 7 A tail gas recovery process is provided for the embodiments of the present application; a human aerosol lung deposition quantification system and an aerosol tail gas recovery system.

[0041] Figure 8 A glucose particle deposition distribution PET-CT image in a human respiratory tract is provided for the embodiments of the present application; a 0.2 μm hydrophilic monodisperse aerosol inhalation deposition distribution image. DETAILED DESCRIPTION

[0042] In order to enable persons skilled in the art to better understand the present application, the technical solutions in the embodiments of the present application will be described clearly and completely below with reference to the accompanying drawings of the embodiments of the present application.

[0043] In some of the processes described in the specification and claims of the present application and the above-mentioned drawings, a plurality of operations appear in a specific order, but it should be clearly understood that these operations can be executed or performed in parallel or in the order in which they appear in this text. The serial numbers of the operations, such as S101, S102, etc., are only used to distinguish different operations, and the serial numbers themselves do not represent any execution order. In addition, these processes can include more or fewer operations, and the operations can be executed in sequence or in parallel. It should be noted that the descriptions of "first", "second", etc. in this text are used to distinguish different messages, devices, modules, etc., and do not represent the order of precedence. Also, "first" and "second" are not of different types.

[0044] Figure 1 The schematic diagram of the method for generating a hydrophilic monodisperse aerosol for human inhalation provided by the embodiments of the present application specifically includes:

[0045] S101: Obtain a hydrophilic aerosol generating liquid;

[0046] In one embodiment, the hydrophilic aerosol generating liquid is a radioactive hydrophilic aerosol generating liquid; the radioactive hydrophilic aerosol generating liquid is fed into an aerosol generator to obtain a first radioactive monodisperse hydrophilic aerosol.

[0047] In one embodiment, the preparation process of the radioactive hydrophilic aerosol generating liquid is as follows:

[0048] To obtain radioactive isotopes and hydrophilic particles;

[0049] The radioactive isotope was added to ultrapure water to obtain a mixed solution;

[0050] The hydrophilic particles are added to the mixed solution, shaken and sonicated to obtain a radioactive hydrophilic aerosol generating liquid.

[0051] In one embodiment, the radioactive isotope includes 18 F-FDG solution.

[0052] In one embodiment, the hydrophilic particles comprise glucose.

[0053] In one embodiment, the ultrasound procedure takes 8-12 minutes.

[0054] In one specific embodiment, a radioactive hydrophilic aerosol is prepared:

[0055] Experimental materials: The main raw materials include ultrapure glucose (Thermo Scientific, USA), ultrapure water, 18 F-FDG, quantitative device for human lung deposition (Hui Ronghe Technology Co., Ltd.), TSI3321 aerodynamic particle size analyzer, TSI scanning electromobility particle size analyzer (TSI3756, TSI3081A, TSI3082, TSI3088), cascade filter (Hui Ronghe Technology Co., Ltd.), flow meter (Hui Ronghe Technology Co., Ltd.), valve (Hui Ronghe Technology Co., Ltd.), air pump (Hui Ronghe Technology Co., Ltd.), aerodynamic particle size separator (Cambustion, UK).

[0056] 10mCi 18 Add F-FDG and 10 mL of ultrapure water to a test tube and shake well to prepare. 18 F-FDG solution, such as Figure 4 As shown, the mass of glucose to be added was then calculated based on the particle size of the generated aerosol and the liquid aerosol generator manual. The glucose was then added to... 18 The solution was mixed with F-FDG solution, shaken and sonicated for ten minutes to obtain aerosol generating liquid. Finally, the generating liquid was added to the generator to generate monodisperse and polydisperse aerosols.

[0057] S102: The hydrophilic aerosol generating liquid is fed into an aerosol generator to obtain a first monodisperse hydrophilic aerosol. The aerosol generator includes a polydisperse aerosol generator and an aerosol particle size separator. The hydrophilic aerosol generating liquid is passed through the polydisperse aerosol generator to generate polydisperse hydrophilic aerosols. The polydisperse hydrophilic aerosols are then screened by the aerosol particle size separator to obtain first monodisperse hydrophilic aerosols with different particle sizes.

[0058] In one embodiment, the first monodisperse hydrophilic aerosol with different particle sizes is a monodisperse hydrophilic aerosol with different particle sizes of less than or equal to 3 μm.

[0059] In one embodiment, the particle size of the first monodisperse hydrophilic aerosol is 25 nm-3 μm.

[0060] S103:

[0061] In one embodiment, the aerosol generator further includes a monodisperse aerosol generator, and the monodisperse aerosol generator and the polydisperse aerosol generator are used to generate a second monodisperse hydrophilic aerosol by passing the hydrophilic aerosol generating liquid through the monodisperse aerosol generator.

[0062] In one embodiment, the second monodisperse aerosol is a monodisperse hydrophilic aerosol with a diameter greater than 3 μm. In another embodiment, the aerosol generator further includes a medical nebulizer, which operates in parallel with the multidisperse aerosol generator and the monodisperse aerosol generator, without interference from each other. The hydrophilic aerosol generating liquid is passed through the medical nebulizer to obtain a multidisperse hydrophilic aerosol.

[0063] In one specific embodiment, the hydrophilic aerosol undergoes monodispersity / polydispersity as follows: Figure 5 As shown, compressed air from an air compressor is filtered through a cascade of filters to obtain clean air. This clean air is then controlled by valves to enter different channels for aerosol generation. These channels are of three types: the first type consists of a polydisperse aerosol generator and an aerodynamic aerosol particle size sorter to generate monodisperse aerosols smaller than or equal to 3 micrometers; the second type uses a flow-aggregating monodisperse aerosol generator to generate monodisperse aerosols larger than 3 micrometers; and the third type uses an air-compressed medical nebulizer to generate polydisperse aerosols. The first type includes a single-particle-size glucose radioactive aerosol generating solution to obtain aerosols of a single particle size. The second type includes glucose radioactive aerosol generating solutions of different concentrations to obtain aerosols of different sizes and quantities.

[0064] In one specific embodiment, the aerosol generation and human inhalation process:

[0065] Experimental equipment: Human lung deposition quantitative device (Hui Ronghe Technology Co., Ltd.), TSI3321 aerodynamic particle size analyzer, TSI scanning electromobility particle size analyzer (TSI3756, TSI3081A, TSI3082, TSI3088), cascade filter (Hui Ronghe Technology Co., Ltd.), flow meter (Hui Ronghe Technology Co., Ltd.), valve (Hui Ronghe Technology Co., Ltd.), air pump (Hui Ronghe Technology Co., Ltd.), human SPECT / CT (Siemens, Germany), filter membrane sampler (Hui Ronghe Technology Co., Ltd.), negative pressure suction device (Siyamei Technology Co., Ltd.).

[0066] First, radioactive glucose was prepared into a monodisperse aerosol and introduced into an oral-nasal exposure tower to create a stable gaseous environment (the aerosol particle size spectrum was monitored using a TSI3321 aerodynamic particle size spectrometer and a TSI scanning electromobility particle size spectrometer).

[0067] In one specific embodiment, the display is achieved through aerosol particle size distribution, such as... Figure 6 As shown, the aerosol particle size distribution shows that the 0.7 μm and 3 μm aerosol particle size distributions have good concentration, with GSD < 1.2, which meets the monodispersity condition.

[0068] In one specific embodiment, the present invention first utilizes a radioactive isotope 18 F-FDG is a technique that uses the principle of miscibility to label soluble glucose to construct radioactive glucose solutions. 18 F-FDG+glucose) was then used to generate micro-nano wide-scale (25nm~10μm) monodisperse radioactive aerosols using a Collision three-hole multidisperse aerosol generator combined with an aerodynamic aerosol particle size sorter and a flow focusing monodisperse aerosol generator. Multidisperse aerosols were generated using an air-compressed medical nebulizer. Then, a pioneering human lung deposition quantitative device combined with an exhaust gas recovery system was used to expose the human body to inhaled radioactive aerosols. Finally, the inhaled human body was subjected to PET / CT high-resolution detection to quantify the deposition distribution.

[0069] The present invention also discloses a computer program product or system, including a computer program that, when executed by a processor, implements the steps of the above-described method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation.

[0070] Figure 2 The schematic diagram of the hydrophilic monodisperse aerosol generation system with different particle sizes for human inhalation provided in this embodiment of the invention specifically includes:

[0071] Acquisition Unit: Acquires hydrophilic aerosol generating liquid;

[0072] The generating unit: the hydrophilic aerosol generating liquid is transported into an aerosol generator to obtain a first monodisperse hydrophilic aerosol; the aerosol generator includes a polydisperse aerosol generator and an aerosol particle size sorting instrument; the hydrophilic aerosol generating liquid generates a polydisperse hydrophilic aerosol through the polydisperse aerosol generator; and the polydisperse hydrophilic aerosol is filtered through the aerosol particle size sorting instrument to obtain the first monodisperse hydrophilic aerosol with different particle sizes.

[0073] Figure 3 The embodiment of the present application provides a schematic diagram of a hydrophilic monodisperse aerosol generating device for human inhalation with different particle sizes, and specifically comprises:

[0074] The memory is used for storing program instructions; and the processor is used for calling the program instructions, so as to execute any one of the above-mentioned methods for generating hydrophilic monodisperse aerosol with different particle sizes for human inhalation.

[0075] The embodiment of the present application further provides a computer readable storage medium, which stores a computer program; and the computer program is executed by a processor to execute any one of the above-mentioned methods for generating hydrophilic monodisperse aerosol with different particle sizes for human inhalation.

[0076] The embodiment of the present application provides a method for generating a deposition distribution diagram of a hydrophilic aerosol in a respiratory tract, which comprises: obtaining a radioactive hydrophilic aerosol according to the above-mentioned method for generating hydrophilic monodisperse aerosol with different particle sizes for human inhalation; and the hydrophilic aerosol comprises one or more of the following: a first monodisperse hydrophilic aerosol, a second monodisperse hydrophilic aerosol and a polydisperse hydrophilic aerosol.

[0077] After the subject inhales the hydrophilic aerosol, tomography is performed on the respiratory tract of the subject to obtain image data of the subject; and a deposition distribution diagram of the hydrophilic aerosol in the respiratory tract is obtained based on the image data of the subject.

[0078] In one embodiment, the method further comprises tail gas recovery; and after the subject inhales the hydrophilic aerosol from the inhalation tower, the remaining radioactive hydrophilic aerosol in the inhalation tower and the exhalation tower is recovered.

[0079] In one specific embodiment, the human oral cavity is exposed to breathing, and the breathing time is 15 minutes. After the exposure is completed, PET / CT is used to quantitatively determine the particle deposition distribution in the human lung. After the experiment is completed, clean air is introduced into the inhalation tower and the exhalation tower, and the remaining tail gas is recovered as shown in Figure 7 .

[0080] In one specific embodiment, the PET-CT quantitative result shows that the deposition distribution of the radioactive glucose particles in the respiratory tract can be quantitatively determined with high resolution, as shown in Figure 8as shown.

[0081] The present application discloses an embodiment of a computer program product or system, comprising a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for quantifying the deposition distribution of hydrophilic aerosols in the respiratory tract.

[0082] The present application discloses an embodiment of a system for quantifying the deposition distribution of hydrophilic aerosols in the respiratory tract, comprising: an acquisition module for obtaining radioactive hydrophilic aerosols according to the above-mentioned method for generating hydrophilic monodisperse aerosols of different particle sizes for human inhalation, wherein the hydrophilic aerosols comprise one or more of the following: first monodisperse hydrophilic aerosols, second monodisperse hydrophilic aerosols, and polydisperse hydrophilic aerosols.

[0083] An imaging module for obtaining imaging data of the subject by tomography of the respiratory tract of the subject after the subject inhales the hydrophilic aerosols.

[0084] A deposition module for obtaining a deposition distribution map of the hydrophilic aerosols in the respiratory tract based on the imaging data of the subject. The present application discloses an embodiment of a computer program product or system, comprising a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for quantifying the deposition distribution of hydrophilic aerosols in the respiratory tract.

[0085] The present application discloses an embodiment of a method for constructing a prediction model of the deposition distribution of hydrophilic particles, comprising:

[0086] According to the above-mentioned method for quantifying the deposition distribution of hydrophilic aerosols in the respiratory tract, a deposition distribution data set of the subject is obtained, and the hydrophilic aerosols of different particle sizes are used as labels.

[0087] The data set and the labels are input into a neural network for training until the loss function is constant, and a deposition prediction model is obtained.

[0088] The present application discloses an embodiment of a computer program product or system, comprising a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for constructing a prediction model of the deposition distribution of hydrophilic particles.

[0089] The present application discloses an embodiment of a system for constructing a prediction model of the deposition distribution of hydrophilic particles, comprising: a particle size module for obtaining a deposition distribution data set of the subject according to the above-mentioned method for generating a deposition distribution map of hydrophilic aerosols in the respiratory tract, and the hydrophilic aerosols of different particle sizes are used as labels.

[0090] Model building module: input the data set and label into the neural network for training until the loss function is constant to obtain a deposition prediction model.

[0091] In one embodiment, the neural network adopts one or more of the following: convolutional neural network, dilated convolutional neural network, residual network, Transformer.

[0092] The prediction model construction device for hydrophilic particle deposition distribution provided by the embodiment of the application specifically comprises: a memory and a processor; the memory is used for storing program instructions; the processor is used for calling the program instructions, when the program instructions are executed, any one of the above-mentioned prediction model construction methods for hydrophilic particle deposition distribution. The embodiment of the application also provides a computer readable storage medium, the computer readable storage medium stores a computer program, and the computer program is executed by the processor to execute any one of the above-mentioned prediction model construction methods for hydrophilic particle deposition distribution.

[0093] The embodiment of the application provides a prediction method for hydrophilic aerosol particle deposition distribution based on different particle sizes, which comprises the following steps:

[0094] Obtaining the particle size of the inhaled hydrophilic aerosol of the to-be-tested person;

[0095] Inputting the particle size into the deposition prediction model obtained by the above-mentioned prediction model construction method for hydrophilic particle deposition distribution to obtain a deposition distribution prediction map.

[0096] The embodiment of the application also provides a computer program product or system, comprising a computer program, which is executed by a processor to implement the above-mentioned prediction method steps for hydrophilic aerosol particle deposition distribution based on different particle sizes.

[0097] The prediction system for hydrophilic aerosol particle deposition distribution based on different particle sizes provided by the embodiment of the application specifically comprises:

[0098] The aerosol unit: obtaining the particle size of the inhaled hydrophilic aerosol of the to-be-tested person;

[0099] The prediction unit: inputting the particle size into the deposition prediction model obtained by the above-mentioned prediction model construction method for hydrophilic particle deposition distribution to obtain a deposition distribution prediction map.

[0100] The prediction device for hydrophilic aerosol particle deposition distribution based on different particle sizes provided by the embodiment of the application specifically comprises:

[0101] The memory is configured to store program instructions, and the processor is configured to invoke the program instructions to implement any one of the above-mentioned methods for predicting the deposition distribution of hydrophilic aerosol particles with different particle sizes.

[0102] The present application also discloses a computer readable storage medium storing a computer program, which, when executed by a processor, implements any one of the above-mentioned methods for predicting the deposition distribution of hydrophilic aerosol particles with different particle sizes.

[0103] The verification results of the verification embodiment show that assigning the inherent weight to the disease can improve the performance of the method compared with the default setting. It can be clearly understood by those skilled in the art that, for the convenience and brevity of description, the specific working processes of the above-described system, device and unit can refer to the corresponding processes in the foregoing method embodiments, which will not be described herein again. In the several embodiments provided by the present application, it should be understood that the disclosed system, device and method can be implemented in other ways. For example, the device embodiments described above are only schematic. For example, the division of the units is only a logical function division. There can be another division manner in actual implementation. For example, a plurality of units or components can be combined or integrated into another system, or some features can be ignored or not executed. In addition, the coupling or direct coupling or communication connection between the units shown or discussed can be indirect coupling or communication connection through some interface, device or unit, and can be electrical, mechanical or other forms. The units described as separated components can or can not be physical separate units, and the units shown as separate components can or can not be physical units, that is, they can be located in one place, or can be distributed on a plurality of network units. Some or all of the units can be selected according to actual needs to achieve the purposes of the embodiments. In addition, each functional unit in the embodiments of the present application can be integrated in one processing unit, or each unit can exist physically, or two or more units can be integrated in one unit. The integrated unit can be in the form of hardware or in the form of software function unit. Those skilled in the art can understand that all or part of the steps of the above-mentioned various methods can be completed by a program instructing related hardware, and the program can be stored in a computer readable storage medium, which can include read only memory (ROM), random access memory (RAM), magnetic disk or optical disk, etc.

[0104] Those skilled in the art can understand that all or part of the steps in the above-mentioned embodiment methods can be instructed by programs to relevant hardware, and the programs can be stored in a computer readable storage medium, such as a read-only memory, a magnetic disk or an optical disk.

[0105] The computer device provided by the present application is described in detail above, and for those skilled in the art, the specific implementation and application range will be changed according to the idea of the embodiment of the present application. In summary, the content of the specification should not be understood as a limitation of the present application.

Claims

1. A method for generating hydrophilic aerosols of different particle sizes for human inhalation, characterized in that, include: Obtain a hydrophilic aerosol generating liquid; The hydrophilic aerosol generating liquid is fed into an aerosol generator to obtain a first monodisperse hydrophilic aerosol; the aerosol generator includes a polydisperse aerosol generator and an aerosol particle size separator, the hydrophilic aerosol generating liquid is passed through the polydisperse aerosol generator to generate polydisperse hydrophilic aerosols, and the polydisperse hydrophilic aerosols are screened by the aerosol particle size separator to obtain first monodisperse hydrophilic aerosols with different particle sizes; The hydrophilic aerosol generating liquid is a radioactive hydrophilic aerosol generating liquid; The radioactive hydrophilic aerosol generating liquid is fed into an aerosol generator to obtain a first radioactive monodisperse hydrophilic aerosol. The preparation process of the radioactive hydrophilic aerosol generating liquid is as follows: Obtain radioactive isotopes and hydrophilic particles; the radioactive isotopes are... 18 F-FDG solution; the hydrophilic particles are glucose; The radioactive isotope was added to ultrapure water to obtain a mixed solution; The hydrophilic particles are added to the mixed solution, shaken and sonicated to obtain a radioactive hydrophilic aerosol generating liquid.

2. The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 1, characterized in that, The first monodisperse hydrophilic aerosol with different particle sizes is a monodisperse hydrophilic aerosol with different particle sizes less than or equal to 3 μm.

3. The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 1, characterized in that, The aerosol generator also includes a monodisperse aerosol generator. The monodisperse aerosol generator and the polydisperse aerosol generator are in a parallel relationship without interference. The hydrophilic aerosol generating liquid is passed through the monodisperse aerosol generator to obtain a second monodisperse hydrophilic aerosol.

4. The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 3, characterized in that, The second monodisperse hydrophilic aerosol is a monodisperse hydrophilic aerosol with a size greater than 3 μm.

5. The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 3, characterized in that, The aerosol generator also includes a medical nebulizer. The medical nebulizer, the polydisperse aerosol generator, and the monodisperse aerosol nebulizer are all parallel and do not interfere with each other. The hydrophilic aerosol generating liquid is passed through the medical nebulizer to obtain polydisperse hydrophilic aerosol.

6. The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 1, characterized in that, The ultrasound procedure takes 8-12 minutes to complete.

7. A quantitative method for the deposition and distribution of hydrophilic aerosols in the respiratory tract, characterized in that, include: The method for generating hydrophilic aerosols of different particle sizes for human inhalation according to claim 5 yields radioactive hydrophilic aerosols, wherein the hydrophilic aerosols include one or more of the following: a first monodisperse hydrophilic aerosol, a second monodisperse hydrophilic aerosol, and a polydisperse hydrophilic aerosol. After the subject inhaled the hydrophilic aerosol, a tomographic scan of the subject's respiratory tract was performed to obtain imaging data of the subject; Based on the image data of the subjects, a deposition distribution map of hydrophilic aerosols in the respiratory tract was obtained.

8. The quantitative method for the deposition and distribution of hydrophilic aerosols in the respiratory tract according to claim 7, characterized in that, The method also includes exhaust gas recovery, whereby the subject inhales hydrophilic aerosols from the inhalation tower and then recovers the remaining radioactive hydrophilic aerosols in the inhalation and exhalation towers.

9. A method for constructing a predictive model for the distribution of hydrophilic particle sediments, characterized in that, include: The quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract according to claim 7 obtains a deposition distribution dataset of the subject, with hydrophilic aerosols of different particle sizes serving as tags; The dataset and labels are fed into a neural network for training until the loss function remains unchanged, thus obtaining a deposition prediction model.

10. A method for predicting the deposition distribution of hydrophilic aerosol particles of different sizes, characterized in that, include: Obtain the particle size of the hydrophilic aerosol inhaled by the test subject; The particle size is input into the deposition prediction model obtained by the prediction model construction method based on hydrophilic particle deposition distribution as described in claim 9 to obtain a deposition distribution prediction map.

11. A computer program product comprising a computer program or instructions, characterized in that, The computer program or instructions are executed by the processor to implement the method for generating hydrophilic aerosols of different particle sizes for human inhalation as described in any one of claims 1-6, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 7, or to implement the method for constructing a predictive model for the deposition distribution of hydrophilic particles as described in claim 9, or to implement the predictive method for the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 10.

12. A computer device comprising a memory, a processor, and a computer program or instructions stored in the memory, characterized in that, The computer program or instructions are executed by the processor to implement the method for generating hydrophilic aerosols of different particle sizes for human inhalation as described in any one of claims 1-6, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 7, or to implement the method for constructing a predictive model for the deposition distribution of hydrophilic particles as described in claim 9, or to implement the predictive method for the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 10.

13. A computer-readable storage medium having a computer program or instructions stored thereon, characterized in that, The computer program or instructions are executed by the processor to implement the method for generating hydrophilic aerosols of different particle sizes for human inhalation as described in any one of claims 1-6, or to implement the quantitative method for the deposition distribution of hydrophilic aerosols in the respiratory tract as described in claim 7, or to implement the method for constructing a predictive model for the deposition distribution of hydrophilic particles as described in claim 9, or to implement the predictive method for the deposition distribution of hydrophilic aerosol particles of different particle sizes as described in claim 10.

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