Self-adaptive ovulation test paper detection method and device

Abstract

The invention discloses a self-adaptive ovulation test paper detection method which comprises the following steps: flatly placing colloidal gold ovulation test paper soaked with urine into a test paper groove of a test paper photographing device, fixing a mobile phone on a mobile phone clamping table of the test paper photographing device, and enabling a mobile phone camera to face the test paper; by adjusting the height of a mobile phone clamping table and the position of a mobile phone of the test paper photographing device, a camera of the mobile phone can shoot a clear and upright test paper picture; analyzing the clear and upright test paper picture to determine the model of the test paper; querying a test paper concentration algorithm database in which a plurality of test paper concentration algorithms are stored according to the determined test paper model to obtain a test paper concentration algorithm corresponding to the test paper model; using the obtained test paper concentration algorithm to process the clear and upright test paper photo to obtain the LH concentration value of the test paper; and estimating the ovulation time according to the LH concentration value of the test paper.

Description

Technical Field

[0001] The present invention relates to the technical field of urine LH concentration monitoring, and in particular to an adaptive ovulation test paper detection method and device. Background Art

[0002] The popularization and development of reproductive health services such as ovulation monitoring can help reduce the incidence of reproductive health problems such as infertility. Through ovulation monitoring, women can accurately predict their ovulation time, thereby increasing the chances of conception. For couples who hope to become pregnant, it is crucial to understand the woman's ovulation situation.

[0003] At present, the main technical means of ovulation monitoring include: basal body temperature monitoring, cervical mucus monitoring, ovulation test strip monitoring, B-ultrasound monitoring, and endocrine hormone monitoring. The above commonly used ovulation monitoring technologies have many problems and cannot conveniently and accurately help pregnant women to detect ovulation. The main defects and shortcomings of the existing technology are as follows:

[0004] 1. Basal body temperature monitoring: refers to the body temperature when you are inactive in the early morning. It is low in the early stage of ovulation, and increases significantly by about 0.2-0.5℃ after ovulation, and continues until the menstruation. Ovulation can be inferred by continuously monitoring the basal body temperature. This method has a low accuracy rate and is affected by factors such as colds, insomnia, drinking, and taking certain drugs.

[0005] 2. Cervical mucus monitoring: Before ovulation, cervical mucus will become thin, transparent, and easy to draw, and the amount of mucus secretion will increase. Ovulation can be monitored by observing cervical mucus. This method requires certain professional knowledge and experience to judge, and is highly subjective.

[0006] 3. Ovulation test strip monitoring: Predict ovulation time by detecting the level of luteinizing hormone (LH) in urine. LH will reach its peak before ovulation, and the test strip will show a strong positive at this time. This method relies on manual observation and comparison of the color changes of the test strips, and cannot quantitatively determine the LH concentration, so the accuracy is limited.

[0007] 4. Ultrasound monitoring: Clinical B-ultrasound examination is used to directly observe the development of the ovaries and follicles, including the size, shape, and number of follicles, to determine the ovulation situation. This method is time-consuming, requires frequent trips to the hospital, and is relatively expensive, which is not conducive to long-term testing.

[0008] 5. Endocrine hormone monitoring: By taking blood to check the endocrine hormone levels, such as estrogen, progesterone, luteinizing hormone, etc., ovulation can be indirectly judged. This method requires going to the hospital for blood tests and requires multiple monitoring, and the operability is poor. Summary of the invention

[0009] The object of the present invention is to provide an adaptive ovulation test strip detection method and device, which avoid the subjective error of manual judgment through the clinical application of ovulation detection by combining the urine LH concentration monitoring of an intelligent semi-quantitative immunochromatographic test strip with clinical examination.

[0010] More specifically, the object of the present invention is to solve the following technical problems existing in the clinical application of ovulation detection by combining the urine LH concentration monitoring of an intelligent semi-quantitative immunochromatographic test strip with clinical examination:

[0011] When taking a photo of an ovulation test strip with a mobile phone, there are problems such as non-standard placement of the test strip and inaccurate focusing.

[0012] It is impossible to perform ovulation detection on various models of ovulation test strips.

[0013] When monitoring with an ovulation test strip, by observing and comparing the color change of the test strip manually, the LH concentration cannot be quantitatively determined, and the accuracy is limited.

[0014] According to the first aspect of the present invention, an adaptive ovulation test strip detection method of the present invention includes:

[0015] Place the colloidal gold ovulation test strip soaked with urine flatly in the test strip groove of the test strip photographing device, and fix the mobile phone on the mobile phone card table of the test strip photographing device so that the mobile phone camera faces the test strip.

[0016] By adjusting the height of the mobile phone card table and the position of the mobile phone of the test strip photographing device, make the mobile phone camera focus and be in the upright position, and take a clear and upright test strip photo.

[0017] Analyze the clear and upright test strip photo to determine the test strip model.

[0018] According to the determined test strip model, query the test strip concentration algorithm database storing multiple test strip concentration algorithms to obtain the test strip concentration algorithm corresponding to the test strip model.

[0019] Use the obtained test strip concentration algorithm to process the clear and upright test strip photo to obtain the LH concentration value of the test strip.

[0020] Estimate the ovulation time according to the LH concentration value of the test strip.

[0021] Preferably, an embodiment of the present invention for determining the test strip model includes: by analyzing the clear and upright test strip photo, obtaining the test strip size parameters in the test strip photo; according to the obtained test strip size parameters, query in the test strip database to obtain the test strip model corresponding to the test strip size.

[0022] Preferably, estimating the ovulation time according to the LH concentration value of the test strip includes:

[0023] Save the LH concentration values of the test strips for the patient over consecutive days calculated from the photos of the test strips for the urine to be tested received over consecutive days;

[0024] According to the change trend of the LH concentration values of the test strips for the patient over consecutive days, estimate that ovulation is about to occur at the time when the LH concentration value of the test strip is close to the peak;

[0025] When it is estimated that ovulation is about to occur for the patient, prompt the patient to undergo sex hormone examination and B-ultrasound examination, and then finally confirm that ovulation is about to occur by using the results of the patient's sex hormone examination and B-ultrasound examination.

[0026] Preferably, the LH concentration value is determined by comparing the RGB difference values of the C, T lines and the middle area on the photo of the immunochromatographic test strip for the urine to be tested.

[0027] Preferably, the RGB difference value diff is calculated according to the following formula:

[0028]

[0029] wherein, R, G, B respectively correspond to the RGB differences between the middle white area and the positions corresponding to the C, T lines, and rmean is the average value of the middle white area and the positions corresponding to the C, T lines on the R channel.

[0030] Preferably, determining the LH concentration value includes:

[0031] Judge whether the color difference value is greater than the color preset threshold;

[0032] If not, it is determined that the color concentration difference at this place is not obvious compared with the original color concentration, and it is judged that there is no result display;

[0033] If so, it is determined that the color concentration difference at this place is obvious compared with the original color concentration, and it is judged that there is a result display, and the corresponding color difference at this place is compared with the color differences in the standard library to confirm the test strip concentration.

[0034] According to another aspect of the present invention, an adaptive ovulation test strip detection device of the present invention includes:

[0035] A test strip photographing device, including:

[0036] A mobile phone card table for fixing the user's mobile phone;

[0037] A test strip groove for flatly placing the colloidal gold ovulation test strip soaked with urine and located directly below the mobile phone card table; and

[0038] An adjustment device for adjusting the height of the mobile phone card table and the position of the mobile phone so that the mobile phone camera focuses and is in a positive position to take a photo of the test strip with a clear and positive image;

[0039] A test strip model determination module, configured to determine the test strip model by analyzing the clear and upright test strip photo.

[0040] A test strip concentration algorithm acquisition module, configured to query a test strip concentration algorithm database storing multiple test strip concentration algorithms according to the determined test strip model, and obtain the test strip concentration algorithm corresponding to the test strip model.

[0041] A test strip LH concentration acquisition module, configured to process the clear and upright test strip photo by using the obtained test strip concentration algorithm to obtain the test strip LH concentration value.

[0042] An ovulation time estimation unit, configured to estimate the ovulation time according to the test strip LH concentration value.

[0043] Preferably, the ovulation time estimation unit includes:

[0044] An LH concentration value storage device, configured to store the test strip LH concentration values of the patient for consecutive days calculated by a test strip LH concentration numerical calculation device based on the immunochromatographic test strip photos of the urine to be detected received for consecutive days.

[0045] An ovulation prediction module, which, according to the change trend of the test strip LH concentration values of the patient for consecutive days, estimates that ovulation of the patient is about to occur at the time when the test strip LH concentration value is close to the peak.

[0046] An ovulation determination module, when the ovulation prediction device estimates that ovulation of the patient is about to occur, prompts the patient to undergo sex hormone examination and B-ultrasound examination, and then finally confirms that ovulation is about to occur by using the sex hormone examination results and B-ultrasound examination results of the patient.

[0047] Preferably, the test strip LH concentration numerical calculation device determines the test strip LH concentration value by comparing the RGB difference values of the C line, T line and the middle area on the immunochromatographic test strip photo of the urine to be detected.

[0048] The present invention solves the technical problems of irregular placement of the test strip and inaccurate focusing when photographing the ovulation test strip through the mobile phone card table of the test strip photographing device and the test strip groove located below the mobile phone card table.

[0049] The present invention identifies and determines the test strip model by analyzing the photographed test strip photo, and performs ovulation detection based on the determined test strip model, realizing adaptation to multiple test strip models.

[0050] The present invention performs automated semi-quantitative calculation of the LH concentration through the ovulation test strip model recognition algorithm and the ovulation test strip LH concentration value algorithm, and solves the technical problem that manual observation and comparison of the color change of the test strip cannot quantitatively determine the LH concentration.

[0051] The present invention has the following beneficial technical effects:

[0052] 1. Adaptation to multiple models of ovulation test strips: The system has strong adaptability and can be compatible with and identify multiple models of ovulation test strips on the market. Without the need for users to manually input the test strip model or perform complex settings, it greatly improves the convenience of the user's ovulation monitoring process.

[0053] 2. Improvement of the quality of mobile phone photos of ovulation test strips: By using the Detection Treasure, it can standardize the correct placement of the ovulation test strip with urine drops by the user, adjust the shooting height and angle of the mobile phone, ensure sufficient lighting and accurate focusing when taking photos, and make the photo of the ovulation test strip clear, thus improving the quality of the ovulation test strip photo;

[0054] 3. Intelligent calculation and calibration of LH concentration: The system can automatically identify the test line and control line of different models of ovulation test strips, extract key information through advanced image processing technology, automatically correct the image, and perform precise calibration, thereby ensuring the accuracy of LH concentration value calculation.

[0055] 4. It can adapt to multiple models of ovulation test strips, which means that users do not need to worry about the problem of test strip model mismatch, greatly improving the convenience and flexibility of use.

[0056] 5. It can automatically identify the color change on the test strip and accurately calculate the LH concentration value. This avoids the subjectivity and errors of manual judgment in traditional methods and improves the accuracy of the results.

[0057] 6. Users can immediately obtain the result of the LH concentration value without waiting or performing complex operations. This instant feedback mechanism helps users promptly understand their own ovulation status, thereby making more scientific pregnancy preparation decisions.

[0058] In addition, the present invention can also automatically record the user's detection data, including test strip photos, LH concentration values, detection time, etc., helping users understand the changing trend of their hormone levels and providing a more comprehensive reference for pregnancy preparation. Brief Description of the Drawings

[0059] Figure 1 is a schematic diagram of an adaptive ovulation test strip detection method of the present invention;

[0060] Figure 2 is a schematic diagram of the test strip photographing device of the present invention;

[0061] Figure 3 is a schematic diagram of an adaptive ovulation test strip detection device of the present invention;

[0062] Figure 4 is a schematic diagram for positioning the C line and T line. Detailed Embodiments

[0063] See Figures 1-3 , an adaptive ovulation test strip detection method of the present invention includes:

[0064] Place the urine-soaked colloidal gold ovulation test strip flatly in the test strip groove 121 of the test strip photographing device 100, and fix the mobile phone on the mobile phone holder 130 of the test strip photographing device 100 so that the mobile phone camera faces the test strip;

[0065] By adjusting the height of the mobile phone holder 130 of the test strip photographing device 100 and the position of the mobile phone, make the mobile phone camera focus and be in the upright position, and take a test strip photo with a clear and upright image;

[0066] Determine the test strip model by analyzing the test strip photo with a clear and upright image;

[0067] According to the determined test strip model, query the test strip concentration algorithm database storing multiple test strip concentration algorithms to obtain the test strip concentration algorithm corresponding to the test strip model;

[0068] Use the obtained test strip concentration algorithm to process the test strip photo with a clear and upright image to obtain the LH concentration value of the test strip;

[0069] Estimate the ovulation time according to the LH concentration value of the test strip.

[0070] See Figure 2 and Figure 3 , the test strip photographing device 100 of the present invention includes a chassis 110; a test strip tray 120 fixed on a part of the chassis 110; a test strip groove 121 provided on the tray 120; a first adjustment seat 151 fixed on another part of the chassis 110; a first cylindrical adjustment knob 150 installed in the first adjustment seat 151 and rotatable; a first support frame 160 with its lower end fixed on the first cylindrical adjustment knob 150; a second adjustment seat (not shown in the figure) fixed on the upper end of the first support frame 160; a cylindrical adjustment knob 140 installed in the second adjustment seat and rotatable; a second support frame (not shown in the figure) with its lower end fixed on the cylindrical adjustment knob 140; a mobile phone holder 170 fixed on the upper end of the second support frame; a mobile phone holder 130 provided above the mobile phone holder 170 and movable along the mobile phone holder.

[0071] An opening (or rectangular through hole) for exposing the mobile phone camera is provided on the mobile phone holder 130 so that the mobile phone camera can take a photo of the test strip below.

[0072] The present invention fixes the mobile phone through the test strip photographing device 100 to prevent the mobile phone from shaking during photographing. By adjusting the knobs 140 and 150, the distance between the mobile phone and the test strip can be adjusted, and a full-screen test strip photo can be taken. By placing the test strip in the test strip groove 121, a standard upright photo can be taken. Compared with the immunochromatographic test strip concentration detection method disclosed in Chinese Patent CN117911352A, the process of rotating the photo to the upright position can be omitted.

[0073] The specific steps of the self-adaptive ovulation test strip detection method of the present invention are as follows:

[0074] Place the colloidal gold ovulation test strip dipped in the user's urine into the test strip groove at the bottom of the detection device, ensuring that all test strips are placed flat and within the groove;

[0075] Fix the user's mobile phone on the mobile phone holder of the detection device, and turn on the camera of the mobile phone to ensure that the mobile phone can clearly capture all the ovulation test strips;

[0076] Open the test strip mobile phone photographing function of the portable reproductive data intelligent evaluation system mini-program, adjust the height of the mobile phone holder of the detection device and the position of the holder and the mobile phone to ensure accurate focusing of the camera, and then take a photo of the test strip.

[0077] Use the portable reproductive data intelligent evaluation system to automatically import the test strip photo just taken by the mobile phone;

[0078] The portable reproductive data intelligent evaluation system mini-program analyzes the test strip photo, applies the ovulation test strip model recognition algorithm, and automatically recognizes multiple models of test strips through this algorithm to quickly determine the current test strip model. The present invention can determine the test strip model in the following ways.

[0079] By analyzing the clear and upright test strip photo, parameters such as the size of the test strip in the test strip photo are obtained; according to the obtained parameters such as the size of the test strip, the test strip model corresponding to the test strip size is obtained by querying the test strip database.

[0080] The present invention can obtain algorithms for different models in the following ways:

[0081] Obtain mainstream ovulation test strips of multiple models, and record indicators such as the size and parameters of the collected ovulation test strips;

[0082] Apply ovulation test strips of multiple models to conduct ovulation detection experiments, and collect the experimental process data and train the model recognition algorithm;

[0083] Based on the data collected from multiple models of test strips, analyze the characteristics of different models of ovulation test strips and construct an ovulation test strip model sample library;

[0084] Refer to the training results of the reference model recognition algorithm, and combine with the data in the ovulation test strip model sample library to complete the ovulation test strip model recognition algorithm.

[0085] After determining the test strip model, query the automatic calculation algorithm for the LH concentration value of the ovulation test strip corresponding to this test strip model from the database, calculate and display the LH value of this test strip to complete the ovulation test strip detection.

[0086] The present invention estimates the ovulation time according to the LH concentration value of the test strip, including: saving the LH concentration values of the test strips of the patient for consecutive days calculated based on the photos of the test strips dipped with the urine to be detected received for consecutive days; according to the change trend of the LH concentration values of the test strips of the patient for consecutive days, estimate that ovulation of the patient is about to occur when the LH concentration value of the test strip is close to the peak; when it is estimated that ovulation of the patient is about to occur, prompt the patient to perform sex hormone examination and B-ultrasound examination, and then finally confirm that ovulation is about to occur by using the results of the patient's sex hormone examination and B-ultrasound examination.

[0087] The present invention determines the LH concentration value by comparing the RGB difference values of the C, T lines and the middle area on the immunochromatographic test strip photo of the urine to be detected. The RGB difference value diff is calculated according to the following formula:

[0088]

[0089] Wherein, R, G, B respectively correspond to the RGB differences between the middle white area and the positions corresponding to the C, T lines, and rmean is the average value of the middle white area and the positions corresponding to the C, T lines on the R channel.

[0090] The present invention determines the LH concentration value in the following way: judge whether the color difference value is greater than the color preset threshold; if not, determine that the color concentration at this place has no obvious difference from the original color concentration and judge it as no result display; if so, determine that the color concentration at this place has an obvious difference from the original color concentration, judge it as having a result display, and compare the corresponding color difference at this place with the color differences in the standard library to confirm the test strip concentration.

[0091] Figure 3 Shows an adaptive ovulation detection device of the present invention, including:

[0092] A test strip photographing device 100, having:

[0093] A test strip groove 101 for flatly placing the colloidal gold ovulation test strip dipped with urine;

[0094] A mobile phone and a mobile phone card table 102 for fixing the mobile phone;

[0095] An adjustment device for adjusting the height of the mobile phone card table 102 and the position of the mobile phone so that the mobile phone camera can take a clear and upright photo of the test strip;

[0096] The test strip model determination module is used to determine the test strip model by analyzing the clear and upright test strip photo.

[0097] The test strip concentration algorithm acquisition module is used to query the test strip concentration algorithm database storing multiple test strip concentration algorithms according to the determined test strip model, and obtain the test strip concentration algorithm corresponding to the test strip model.

[0098] The test strip LH concentration acquisition module is used to process the clear and upright test strip photo by using the obtained test strip concentration algorithm, and obtain the test strip LH concentration value.

[0099] The ovulation time estimation unit is used to estimate the ovulation time according to the test strip LH concentration value.

[0100] The ovulation time estimation unit of the present invention includes: an LH concentration value storage device for storing the test strip LH concentration values of the patient for consecutive days calculated by the test strip LH concentration value calculation device based on the immunochromatographic test strip pictures of the urine to be detected received for consecutive days; an ovulation prediction device for predicting that the ovulation of the patient is about to occur at the time when the test strip LH concentration value is close to the peak according to the change trend of the test strip LH concentration values of the patient for consecutive days; an ovulation determination device for prompting the patient to perform sex hormone examination and B-ultrasound examination when the ovulation prediction device predicts that the ovulation of the patient is about to occur, and then finally confirming that the ovulation is about to occur by using the sex hormone examination result and B-ultrasound examination result of the patient.

[0101] In a preferred embodiment of the present invention, the test strip LH concentration value acquisition module, the LH concentration value storage device, the ovulation prediction module and the ovulation determination module are all arranged in the mobile phone.

[0102] The present invention determines the concentration by comparing the RGB difference values of the C line, T line and the middle area on the test strip picture.

[0103] As Figure 4 shown, the positioning methods of the test strip C line and T line are as follows:

[0104] The test strip result display area is evenly divided into upper and lower areas, and the following operations are respectively performed on the two areas to obtain the positions of the C line and T line;

[0105] Convert the segmented image into RGB three-channel data;

[0106] Calculate the average value of the G channel of each row of the segmented image; (because the difference between the white area of the test strip and the red result display area is the most obvious in the G channel)

[0107] Calculate the average value of the G channel of the middle 10% part of the original image; (because the middle part is closest to white and has no noise; the selection of 10% avoids a large amount of calculation and ensures a relatively high accuracy of the obtained average value)

[0108] Find the row position with the largest difference from the average value of the G channel in the middle part, and the position of the darkest color, which is the position of the C line or the T line.

[0109] The LH concentration value calculation device of the test strip of the present invention determines the LH concentration value of the test strip by comparing the RGB difference values between the C and T lines and the middle area on the immunochromatographic test strip image of the urine to be detected. The RGB difference value diff is calculated according to the following formula:

[0110]

[0111] Among them, R, G, and B respectively correspond to the RGB differences between the middle white area and the positions corresponding to the C and T lines, and rmean is the average value of the middle white area and the positions corresponding to the C and T lines on the R channel.

[0112] Determining the LH concentration value of the test strip includes: judging whether the color difference value is greater than the color preset threshold; if not, it is determined that the color concentration difference at this place is not obvious from the original color concentration, and it is judged as no result display; if so, it is determined that the color concentration difference at this place is obvious from the original color concentration, and it is judged as having a result display, and the corresponding color difference at this place is compared with the color differences in the standard library to confirm the test strip concentration.

[0113] Color preset threshold: After taking multiple test strips with different concentrations and calculating the concentrations 0 and 10 (the lowest concentration prepared) by the above method, as many values as possible can be distinguished.

[0114] Color differences in the standard library: Take multiple test strips with different concentrations, calculate the color difference values corresponding to the C and T lines at different concentrations by the above method, and determine the color difference standard values corresponding to different concentrations by regression. For example, concentration 10 corresponds to x1, concentration 15 corresponds to x2, etc.

[0115] The test strip models of the present invention correspond to different concentrations one by one. Therefore, by determining the color preset values of different model test strips and the color differences in the standard library, the test strip concentration algorithms for different model test strips can be determined.

[0116] The ovulation detection principle of the present invention is to predict the ovulation time by detecting the luteinizing hormone (LH) level in urine. The luteinizing hormone will reach a peak before ovulation, and the appearance of this peak usually indicates that ovulation is about to occur. The specific operations include:

[0117] Select the test time: Start the test at a specific stage of the menstrual cycle. Generally, it is recommended to start 5 - 7 days before ovulation and test at a fixed time every day to more accurately capture the changes in LH levels.

[0118] Collect urine: Use a dry and clean container to collect a urine sample. Note that do not use the first urine in the morning because the LH level at this time may be unstable due to various factors. It is recommended to collect urine between 10 am and 8 pm.

[0119] Take out the test strip: Tear open the aluminum foil bag and take out the semi-quantitative ovulation test strip.

[0120] Dip into urine: Vertically dip the absorbent end of the test strip (usually the end pointed by the arrow) into the urine for a certain period of time (such as 20 seconds or 30 seconds), and the specific time depends on the test strip instruction manual. Note that do not let the urine level exceed the maximum line on the test strip.

[0121] Take out the test strip: After taking out the test strip from the urine, place it flat on a dry and clean surface.

[0122] Wait for reaction: Wait for the reaction according to the time requirement on the test strip instruction manual, generally 5 - 10 minutes or longer.

[0123] Observe the color band: Observe the change of the color band in the middle section of the test strip. The depth of the color of the color band reflects the concentration of LH in the urine.

[0124] Compare with the color card: Compare the color band on the test strip with the color card attached to the test strip, find the color block closest to the color of the color band, and record the corresponding value.

[0125] Record the value: After each test every day, record the value on the test strip. As the LH level increases, the value will also increase accordingly.

[0126] Observe the trend: After testing for several consecutive days, observe the change trend of the values. When the values start to rise significantly, it indicates that the LH level is approaching the peak.

[0127] Estimate the ovulation time: When the value reaches or approaches the peak value (such as 65), it indicates that ovulation is about to occur. At this time, the test frequency can be increased (such as testing once every 4 hours) to more accurately capture the ovulation time. When the value starts to decline from the peak (such as from 65 to 45), it indicates that ovulation has occurred or is about to end.

[0128] Maintain the consistency of testing: Try to conduct the test at the same time every day and use the same urine collection method.

[0129] Avoid interfering factors: Avoid activities that may affect the LH level such as drinking a large amount of water or doing strenuous exercise before the test.

[0130] The present invention can be combined with other methods (such as sex hormone detection, B-ultrasound examination, etc.) to improve the accuracy of ovulation detection.

[0131] Steps for identifying the rule between ovulation time and the self-detected LH concentration value:

[0132] 1. Since the LH peak usually appears 1 - 2 days before ovulation, ovulation occurs within 24 - 36 hours after the peak. An ovulation test strip is used to detect the LH concentration in urine through an intelligent recognition algorithm. When the ovulation test strip detects a sharp rise in the LH concentration, forming an "LH peak", it indicates that ovulation is about to occur.

[0133] 2. At this time, the ovulation monitor immediately goes to the hospital for sex hormone examination and B - ultrasound examination. When the sex hormone test results show a sharp rise in estrogen level and the LH test strip also shows a strong positive result, it can be further confirmed that ovulation is about to occur. At the same time, check the prog (progesterone) value. The normal value is usually between 0.2 - 0.6 ng / ml during ovulation and 6.5 - 32.2 ng / ml after ovulation.

[0134] 3. The development of follicles can be directly observed through color ultrasound examination. Before ovulation, the follicles gradually grow and mature. During ovulation, the follicles rupture and release eggs, and at this time, the disappearance or collapse of the follicles can be seen in the ultrasound examination.

[0135] 4. The doctor combines the self - measured LH concentration value, sex hormone test results, and ultrasound examination results: Through comprehensive analysis of the LH concentration value detected by the ovulation test strip, sex hormone test results, and color ultrasound examination results, the ovulation time can be accurately judged. When the LH test strip shows a strong positive reaction, the sex hormone test shows a sharp rise in estrogen level, and the ultrasound examination shows that the follicles are mature, it can be confirmed that ovulation is about to occur.

[0136] Record the self - measured LH concentration value at this time. This LH concentration is the concentration when ovulation is about to occur for the ovulation monitor. When the LH concentration is detected at this level again during subsequent automatic LH concentration detection, it represents that ovulation is about to occur.

[0137] For example, when a certain girl Xiaoli who is preparing for pregnancy conducts ovulation self - testing, when the self - measured LH concentration is 60 in a certain test, which is close to the peak concentration. After consulting a doctor, she goes to the hospital for sex hormone testing and ultrasound examination. After the examination, it is found that the sex hormone test shows a sharp rise in estrogen level and the ultrasound examination shows that the follicles are mature. Record the concentration 60 at this time, which is the concentration when Xiaoli is about to ovulate. When the LH concentration reaches 60 again next time, it is the time of impending ovulation.

[0138] The usage method of the present invention is as follows: The patient uses the mobile phone "Pregnancy Hope" WeChat mini-program integrated with the self-developed immunochromatographic test strip urine LH concentration automatic detection algorithm. The patient takes a photo of the immunochromatographic test strip dropped with the urine to be tested using the mobile phone, and then uploads the photo to the "Pregnancy Hope" mini-program. At this time, the mini-program will automatically calculate the LH concentration value of the test strip and record it in the system. The assisted reproductive medicine doctor combines the LH concentration values detected for the patient multiple times to estimate the ovulation time. At the same time, the patient is given venous blood sex hormone detection and color ultrasound examination. By comparing the LH concentration value automatically identified by the mini-program for the immunochromatographic test strip, the sex hormone detection result, and the color ultrasound examination result, the rule between the ovulation time and the self-detected LH concentration value is identified. After discovering the ovulation rule, the patient can realize the independent detection of the LH concentration of the immunochromatographic test strip through the "Pregnancy Hope" mini-program, accurately judge the ovulation time, and provide support for successful conception.

[0139] The clinical application mode of ovulation detection proposed by this medical technology, which combines the intelligent semi-quantitative immunochromatographic test strip urine LH concentration monitoring with clinical examinations, is an effective, convenient, and accurate ovulation monitoring method that can help women waiting for pregnancy to discover the ovulation rule in time and determine the ovulation time.

[0140] By combining the WeChat mini-program, the intelligent immunochromatographic test strip urine LH concentration detection technology with blood tests and color ultrasounds in medical institutions, it is convenient for patients to accurately perform ovulation detection at home independently, reasonably determine the ovulation date, and avoid the problem that the artificial independent judgment using a single immunochromatographic test strip is greatly affected by subjective factors and is inaccurate. At the same time, it avoids the problems of high time and economic costs and unsustainability caused by frequent visits to medical institutions for testing.

[0141] The present invention can automatically identify the LH concentration value by taking a photo of the immunochromatographic test strip using the WeChat mini-program. Compared with the traditional methods of artificial basal body temperature monitoring, cervical mucus monitoring, and ovulation test strip monitoring, it avoids the subjective error of artificial judgment, is more convenient to operate, and the quantitative LH value is more objective.

[0142] The present invention can automatically identify the LH concentration value by taking a photo of the immunochromatographic test strip using the WeChat mini-program. Compared with the traditional method of going to a medical institution for color ultrasound examination and blood test to determine whether ovulation occurs, it has lower costs, is more convenient, and has stronger sustainability.

[0143] The present invention can automatically detect the LH concentration in the immunochromatographic test strip dropped with the urine to be tested through an intelligent algorithm, and can semi-quantitatively give the LH concentration value, helping patients to use the immunochromatographic test strip at home more conveniently and economically.

[0144] The present invention combines the autonomous intelligent detection of the urine LH concentration in the immunochromatographic test strip with the blood test and ultrasound examination items carried out by medical institutions, and can accurately discover the law of the LH concentration and ovulation time of individual patients, so as to autonomously, conveniently and accurately help patients determine the ovulation time.

[0145] Although the present invention has been described in detail above, the present invention is not limited thereto, and those skilled in the art of the present technology can make various modifications according to the principle of the present invention. Therefore, all modifications made according to the principle of the present invention should be understood to fall within the protection scope of the present invention.

Claims

1. An adaptive ovulation test strip detection method, comprising: Placing the colloidal gold ovulation test paper soaked in urine evenly into the test paper groove (121) of the test paper photographing device (100), and fixing a mobile phone on the mobile phone card stand (130) of the test paper photographing device (100) so that the mobile phone camera faces the test paper; By adjusting the height of the mobile phone card stand (130) of the test paper photographing device (100) and the position of the mobile phone, the mobile phone camera can take a clear and upright test paper photograph; Determine the model of the test paper by analyzing the test paper photo with a clear and upright image; According to the determined test paper model, querying a test paper concentration algorithm database storing a plurality of test paper concentration algorithms to obtain a test paper concentration algorithm corresponding to the test paper model; Using the obtained test paper concentration algorithm, the test paper photo with a clear and upright image is processed to obtain the LH concentration value of the test paper; The ovulation time is estimated according to the LH concentration value of the test paper.

2. According to the adaptive ovulation test paper detection method of claim 1, determining the test paper model comprises: By analyzing the clear and upright test paper photo, the test paper size parameters in the test paper photo are obtained; According to the acquired test paper size parameters, the test paper database is queried to obtain the test paper model corresponding to the test paper size.

3. The adaptive ovulation test strip detection method according to claim 1, estimating the ovulation time according to the LH concentration value of the test strip comprises: Save the patient's test paper LH concentration values ​​for consecutive days calculated based on the test paper photos of the urine to be tested received for consecutive days; According to the changing trend of the LH concentration value of the test paper for several consecutive days, the time when the LH concentration value of the test paper is close to the peak is used to estimate the patient's ovulation. When it is estimated that the patient is about to ovulate, the patient is prompted to undergo sex hormone tests and B-ultrasound examinations, and then the patient's sex hormone test results and B-ultrasound examination results are used to finally confirm that ovulation is about to occur.

4. The adaptive ovulation test strip detection method according to claim 3, wherein the LH concentration value is determined by comparing the RGB difference values ​​of the C and T lines and the middle area on the immune layer test strip photo of the urine to be tested.

5. The adaptive ovulation test paper detection method according to claim 4, wherein: The RGB difference value diff is calculated as follows: Among them, R, G, and B correspond to the RGB difference between the middle white area and the corresponding positions of the C and T lines, respectively, and rmean is the average value of the middle white area and the corresponding positions of the C and T lines on the R channel.

6. According to the adaptive ovulation test strip detection method of claim 4 or 7, determining the LH concentration value comprises: Determine whether the color difference value is greater than the color preset threshold; If not, it is determined that the color concentration at this location is not significantly different from the original color concentration, and it is judged that no result is displayed; If so, it is determined that the color concentration at this location is significantly different from the original color concentration, and it is judged that there is a result to be displayed. The corresponding color difference at this location is compared with the color difference in the standard library to confirm the test paper concentration.

7. An adaptive ovulation test strip detection device, comprising: A test paper photographing device (100), comprising: A test paper groove (101) for evenly placing a colloidal gold ovulation test paper soaked in urine; A mobile phone and a mobile phone card station (102) for fixing the mobile phone; An adjustment device, used for adjusting the height of the mobile phone card stand (102) and the position of the mobile phone, so that the mobile phone camera can take a clear and upright test paper photo; A test paper model determination module, used to determine the test paper model by analyzing the clear and upright test paper photo; A test paper concentration algorithm acquisition module is used to query a test paper concentration algorithm database storing a plurality of test paper concentration algorithms according to the determined test paper model, and obtain a test paper concentration algorithm corresponding to the test paper model; A test paper LH concentration acquisition module, used to process the clear and upright test paper photo using the obtained test paper concentration algorithm to obtain the test paper LH concentration value; The ovulation time estimation unit is used to estimate the ovulation time according to the LH concentration value of the test paper.

8. According to the adaptive ovulation test strip detection device of claim 7, the test strip model determination module determines the test strip model by the following method: By analyzing the clear and upright test paper photo, the test paper size parameters in the test paper photo are obtained; According to the acquired test paper size parameters, the test paper database is queried to obtain the test paper model corresponding to the test paper size.

9. The adaptive ovulation test strip detection device according to claim 7, wherein the ovulation time estimation unit comprises: An LH concentration value storage device is used to store the LH concentration values ​​of the test paper of the patient for a number of consecutive days calculated by the test paper LH concentration numerical calculation device based on the photos of the immune layer test paper with the urine to be tested received for a number of consecutive days; The ovulation prediction module estimates that the patient's ovulation is about to occur based on the change trend of the patient's test strip LH concentration value for several consecutive days and the time when the test strip LH concentration value is close to the peak; The ovulation confirmation module prompts the patient to undergo a sex hormone test and a B-ultrasound examination when the ovulation prediction device predicts that the patient is about to ovulate, and then uses the patient's sex hormone test results and the B-ultrasound examination results to finally confirm that ovulation is about to occur.

10. The adaptive ovulation test strip detection device according to claim 9, wherein the test strip LH concentration numerical calculation device determines the test strip LH concentration value by comparing the RGB difference values ​​of the C and T lines and the middle area on the immune layer test strip photo of the urine to be tested.

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