Pelson berry composition and application thereof in improvement of lung health

Abstract

The invention belongs to the technical field of special meals, and particularly relates to a boessen berry composition and application thereof in improvement of lung health. The Ponsenberry is a convergent hybrid berry fruit formed by hybridizing European raspberry, European blackberry, American raspberry and American Rouslutian berry. The rubus bosenii is rich in high-concentration anthocyanin, plant polyphenol, dietary folic acid, dietary fibers, beta-carotene and various vitamins and trace elements. The effects of enhancing immunity, freeing lung, relieving sore-throat and promoting healthy cell division are achieved. According to the boessen berry composition disclosed by the invention, through the synergistic cooperation of various components and the adoption of an innovative preparation method, the effect of improving lung health is remarkable, and the boessen berry composition has the characteristics of being good in mouth feel, strong in immunity improving effect and high in stability.

Description

Technical Field

[0001] The present invention belongs to the technical field of special dietary beverages, and particularly relates to a boysenberry composition and its application in improving lung health. Background Art

[0002] Boysenberry is a composite hybrid berry formed by crossing European raspberry, European blackberry, American raspberry and American loganberry. Boysenberry is rich in high concentrations of anthocyanins, plant polyphenols, dietary folic acid, dietary fiber, β-carotene, as well as various vitamins and trace elements. It has the effects of enhancing immunity, promoting the dispersing of the lung qi and alleviating sore throat, and promoting the division of healthy cells. To improve the role of boysenberry in improving lung health, other components are generally added to boysenberry to enhance the synergistic effect, but this will also cause problems such as poor taste of the composition and easy loss of active ingredients.

[0003] In 2018, "CN 110996981A" disclosed a boysenberry, apple and blackcurrant composition, its preparation method and uses, and specifically disclosed the role of the composition in preventing or treating respiratory inflammation. The specific preparation method of the composition was not disclosed in the specification. Since boysenberry is rich in anthocyanins, if the preparation process is improper, anthocyanin loss is likely to occur, resulting in a deterioration of the effect of the final composition in preventing or treating respiratory inflammation.

[0004] In 2024, "CN118452376A" disclosed a composition, beverage, preparation method and uses with anti-photoaging, anti-glycation and antioxidant functions. The claims disclosed that: mixing the concentrated boysenberry juice, the white tomato powder, the Phyllanthus emblica powder, the white onion powder, the concentrated pomegranate powder, the olive fruit powder, the red grape yeast complex powder and the water to obtain the composition. From the preparation method and the composition of the composition, it can be concluded that the composition has problems such as poor taste, easy sedimentation, and easy loss of active ingredients of boysenberry.

[0005] In summary, the existing compositions using boysenberry as an active component for improving lung health generally have problems such as poor taste during use, easy sedimentation, and easy loss of active ingredients during the preparation process. Summary of the Invention

[0006] The technical problems to be solved by the present invention are: the problems of poor taste, easy sedimentation, and easy loss of active components existing in the boysenberry composition suitable for improving lung health.

[0007] Technical solution adopted by the present invention: A boysenberry composition, the composition comprising boysenberry concentrated juice, small molecule peptides and herbal components. The boysenberry composition of the present invention is composed of boysenberry concentrated juice, small molecule peptides and herbal components. Among them, the boysenberry concentrated juice is the most important component for improving lung health, having the function of repairing damaged lung tissues and maintaining lung health. It helps to remove foreign substances such as mucus, phlegm, and dust. It has super antioxidant capacity, anti-inflammatory effect and immune enhancement. It helps to lower blood pressure, reduce blood lipids and improve blood vessel function. The small molecule peptides, as supplements, further enhance the body's resistance and balance the immune mechanism, especially having an obvious effect on improving infantile bronchial asthma. The herbal components are used to improve the taste of the composition, relieve cough and reduce phlegm, clear heat and detoxify, regulate qi and harmonize the middle, and are a beneficial supplement to the composition for improving lung health. The three components nourish the spleen and benefit the lungs on the premise of having a good taste, and precisely care for lung health in a trinity manner.

[0008] The above is the basic technical solution of the present invention. To facilitate the understanding and implementation of the technical solution of the present invention by those skilled in the art, the present invention also has the following additional technical features:

[0009] In a preferred technical solution, the mass ratio of the boysenberry concentrated juice, small molecule peptides, and herbal components is 1: 0.35 - 0.55: 3.0 - 10.0. The boysenberry concentrated juice in the composition of the present invention is the most important component for improving lung health and has the most significant effect. The purpose of the other small molecule peptides and herbal components is to be a beneficial supplement to the boysenberry concentrated juice in improving lung health. The inventor determined through comparative experiments that when the ratio of boysenberry concentrated juice: small molecule peptides: herbal components is 1: 0.35 - 0.55: 3.0 - 10.0, the best synergistic effect of removing toxins, repairing tissues, and coordinating protection can be achieved.

[0010] In a preferred technical solution, the small molecule peptides include bovine spleen peptides and albumin peptides; the mass ratio of the bovine spleen peptides and albumin peptides is 1: 0.01 - 0.04. Bovine spleen peptides have the functions of enhancing immunity, protecting the liver and improving sleep. Albumin peptides also have the functions of enhancing immunity and protecting the liver. At the same time, it can also supplement nutrition and promote growth and development. The synergistic effect of the two further enhances the immune regulation effect. The present invention adopts a mass ratio of bovine spleen peptides and albumin peptides of 1: 0.01 - 0.04 to achieve the best synergistic effect.

[0011] In a preferred technical solution, the herbal component includes apple juice and at least one of orange red, liquorice, sophora flower bud, phyllanthus emblica, dried tangerine peel, almond, chrysanthemum, monk fruit, and platycodon grandiflorum; the mass ratio of the apple juice to the other components in the herbal component except the apple juice is 1:0.005 - 0.05. In the present invention, the herbal component improves the effects of relieving cough and resolving phlegm, clearing heat and detoxifying, regulating qi and harmonizing the middle-jiao through synergistic cooperation. In particular, the largest weight ratio of apple juice in the herbal component, in combination with the boysenberry concentrated juice, makes the composition have a sweet and refreshing berry flavor and is more easily accepted by infants and young children.

[0012] In a preferred technical solution, the composition further includes a thickener; the mass ratio of the boysenberry concentrated juice to the thickener is 1:0 - 0.3; the thickener is selected from at least one of xanthan gum, pectin, guar gum, acetylated distarch phosphate, arabic gum, microcrystalline cellulose, and lecithin. The addition of the herbal component in the composition improves the effects of enhancing immunity, moistening the lungs and relieving cough, and relieving cough and resolving phlegm. However, when the composition is used as a special dietary drink, the addition of the herbal component sometimes exists in the form of insoluble substances, affecting the uniformity and taste. To solve this problem, the present invention adds a thickener to the composition to make the insoluble substances in the composition more easily suspended in the system and improve the problem of poor uniformity. The mass ratio of the boysenberry concentrated juice to the thickener is 1:0 - 0.3. When the components forming insoluble substances in the herbal component are few or none, the thickener can be not added. On the contrary, a relatively larger proportion of the thickener needs to be added. The thickener is selected from at least one of xanthan gum, pectin, guar gum, acetylated distarch phosphate, arabic gum, microcrystalline cellulose, and lecithin. The above thickeners have good thickening effects and no adverse effects and can be selected according to needs.

[0013] The present invention also discloses a preparation method of the boysenberry composition as described above, specifically including the following steps:

[0014] (1) Fresh apples are washed, dried, peeled, cored, and juiced to form apple juice;

[0015] (2) The herbal components except apple juice are pulverized by a pulverizer and sieved to form fine herbal component powder;

[0016] (3) Add apple juice, fine herbal component powder, and thickener to an emulsifying kettle, and start a high-speed shearing device for high-speed shearing to form a suspension;

[0017] (4) The suspension is homogenized by a homogenizer for multiple times to form a homogeneous liquid;

[0018] (5) The homogeneous liquid is degassed by a deaerator to form a degassed liquid;

[0019] (6) Under nitrogen protection, boysenberry concentrated juice and small molecule peptides are added to the degassed liquid, and after stirring and mixing, a boysenberry composition is formed.

[0020] Different from the prior art which prepares the boysenberry composition through a simple mixing process, the present invention prepares the boysenberry composition in a manner similar to the preparation of microemulsion, solving the problem that the herbal components are prone to sedimentation and stratification. Through the combination of an innovative process and equipment, the problem that the boysenberry concentrated juice and small molecule peptides are prone to loss during the preparation of the composition is solved. The taste of the composition is improved through the combination of various herbal components, and it serves as a beneficial supplement to the role of the boysenberry concentrated juice and small molecule peptides in improving lung health.

[0021] In the specific preparation process, first, fresh apples are washed, dried, peeled, cored, and juiced to form apple juice. The herbal components other than apple juice are pulverized by a pulverizer and sieved to form fine herbal component powder. Apple juice contains sufficient water and can serve as a natural source of water in the composition. The other herbal components except apple juice need to be pulverized by a pulverizer to form fine herbal component powder. The particle size of the fine herbal component powder should be as small as possible, which is very beneficial for improving the uniformity of the final composition. A centrifugal pulverizer or a sand mill can be selected to pulverize the herbal components other than apple juice. Then, apple juice, fine herbal component powder, and a thickener are added to an emulsifying kettle, and a high-speed shearing device is turned on for high-speed shearing to form a suspension. The suspension is homogenized by a homogenizer multiple times to form a homogenized liquid. The homogenized liquid is degassed by a degasser to form a degassed liquid. At this time, the suspension is in a state where the herbal components are suspended in apple juice. The function of the thickener is similar to that of a wall material, separating the herbal component particles to avoid flocculation and improving the stability of the suspension. After the suspension is homogenized by the homogenizer multiple times, the particle size of the herbal components is further reduced to the micron level, and the obtained homogenized liquid is more stable. The homogenized liquid is degassed by a degasser, which can remove the gas brought in by high-speed shearing and the raw materials themselves completely, avoiding the subsequent oxidative damage to the boysenberry concentrated juice and small molecule peptides. The degasser spreads the homogenized liquid evenly on the inner surface of an inverted conical cylinder to form a thin layer with a thickness of only a few millimeters, and uses a vacuum system to remove the gas in the homogenized liquid completely. This degassing method can reduce the adverse effect of liquid column static pressure on the gas removal process, especially when the viscosity of the homogenized liquid is high, the effect is more significant. Finally, under nitrogen protection, boysenberry concentrated juice and small molecule peptides are added to the degassed liquid, and after stirring and mixing, a boysenberry composition is formed. In the preparation process of the present invention, the boysenberry concentrated juice and small molecule peptides are added at the end. At this time, the dissolved oxygen in the system has been reduced to the lowest level, avoiding the oxidative damage to the boysenberry concentrated juice and small molecule peptides. If when preparing a high-concentration boysenberry composition, the boysenberry concentrated juice and small molecule peptides are added before preparing the suspension, a high-pressure and high-temperature environment will be formed in the local area of the equipment during high-speed shearing and homogenization, which is very unfavorable for maintaining the stability of the boysenberry concentrated juice and small molecule peptides.

[0022] In a preferred technical solution, the mesh number of the sieve used in the sieving process of step (2) is 100-300 meshes. The sieve needs to separate large particles in the crushed herb components to avoid their adverse effects on the stability of the subsequent suspension. On the other hand, large particles will be throttled by the filter element of the homogenizer before entering the homogenizer, which is likely to cause blockage and affect the normal homogenization process. Here, the mesh number of the sieve should be as large as possible, and the sieved large particle herb components can be reused after repeated crushing.

[0023] In a preferred technical solution, the number of times of the homogenization process by the multi-stage homogenizer in step (4) is 3-8 times; the pressure of the homogenization process is 10-40 MPa. During the homogenization process, cooling measures should be taken for the material, and the temperature should be controlled at 20-30 °C as much as possible. The more times of homogenization, the more stable the obtained suspension is, and the less likely it is to occur the problem of flocculation. However, too many times of homogenization will also increase energy consumption and prolong the time. Generally, homogenization more than 3 times can meet the requirements.

[0024] In a preferred technical solution, the pressure of the degassing process by the degasser in step (5) is -0.08 to -0.095 MPa. As mentioned above, the degasser improves the degassing effect by reducing the hydrostatic pressure of the liquid column. The higher the operating vacuum degree during degassing, the more water evaporates, which will cause the viscosity of the homogenized liquid to increase and the solid content to increase. On the contrary, the lower the operating vacuum degree during degassing, the less water evaporates, but there is also the problem of incomplete degassing. When controlling the temperature of the homogenized liquid at 20-30 °C, controlling the degassing pressure of the degasser at -0.08 to -0.095 MPa has the best effect.

[0025] The present invention also discloses an application of a boysenberry composition. The boysenberry composition is prepared by the preparation method as described above, and the boysenberry composition is applied to improve lung health. The boysenberry composition described in the present invention is similar to a microemulsion, and has the characteristics of fast absorption, high stability, and difficult loss of active components.

[0026] In summary, the present invention improves the role of the composition in improving lung health through the synergistic effect of boysenberry concentrated juice, small molecule peptides and herb components, achieving the effect of 1+1+1>3. By introducing the herb component apple juice, the taste of the composition is improved. During the preparation process, the stability of the composition is improved through high-speed shearing and homogenization. Through the degassing process, the oxygen content in the composition is reduced, and the possibility of oxidation and damage of boysenberry concentrated juice and small molecule peptides is reduced. By adding boysenberry concentrated juice and small molecule peptides at the end of the preparation process, the loss of active components of boysenberry concentrated juice and small molecule peptides is further reduced. Specific Embodiments

[0027] The present invention will be specifically described below through examples, but the present invention is not limited to these examples.

[0028] Preparation of herbal components:

[0029] Take about 200 g of tangerine peel, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine tangerine peel powder for standby.

[0030] Take about 200 g of liquorice root, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine liquorice root powder for standby.

[0031] Take about 200 g of sophora flower buds, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine sophora flower bud powder for standby.

[0032] Take about 200 g of phyllanthus emblica fruits, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine phyllanthus emblica fruit powder for standby.

[0033] Take about 200 g of dried tangerine peel, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine dried tangerine peel powder for standby.

[0034] Take about 200 g of apricot kernels, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine apricot kernel powder for standby.

[0035] Take about 200 g of chrysanthemums, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine chrysanthemum powder for standby.

[0036] Take about 200 g of monk fruits, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine monk fruit powder for standby.

[0037] Take about 200 g of platycodon roots, grind it into fine powder in a pulverizer and sieve it through a 100-mesh sieve to remove large particles, obtaining fine platycodon root powder for standby.

[0038] Take about 30 kg of red delicious apples, wash, dry, peel, core and cut them into pieces, then juice them in a juicer to obtain apple juice for standby.

[0039] Example 1

[0040] (1) Preparation of suspension:

[0041] Put into the emulsifying kettle: 1.75 kg of apple juice, 5.4 g of fine tangerine peel powder, 7.4 g of fine liquorice root powder, 6.0 g of fine sophora flower bud powder, 3.8 g of fine phyllanthus emblica fruit powder, 4.6 g of fine dried tangerine peel powder, 4.8 g of fine apricot kernel powder, 8.0 g of fine chrysanthemum powder, 3.0 g of fine monk fruit powder, 2.0 g of fine platycodon root powder. Turn on the high-speed shearing device, set the rotation speed at 8000 r / min, and carry out shearing emulsification. Control the temperature inside the emulsifying kettle at 20 - 30 °C through the jacket low-temperature water. After high-speed shearing is completed, obtain the suspension.

[0042] (2) High-pressure homogenization:

[0043] Homogenize the suspension through a high-pressure homogenizer, controlling the homogenization pressure at 20 MPa. After each homogenization, cool the material to 20 °C with ice water. Repeat the homogenization a total of 5 times, and measure the particle size: D(90) = 3.825 μm.

[0044] (3) Degassing:

[0045] Continuously transport the homogenized liquid into a degasser through a rotor pump for degassing, controlling the degasser pressure at -0.085 MPa to obtain a degassed liquid.

[0046] (4) Mixing:

[0047] Under nitrogen protection conditions, add 250.0 g of boysenberry concentrate, 100.0 g of bovine collagen peptide, and 2.5 g of albumin peptide to the degassed liquid, and start stirring to mix evenly. After sterilization, obtain the boysenberry composition, and package it into small packages of 10 ml / bag.

[0048] (5) Evaluation:

[0049] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at high speed for 10 minutes under the condition of controlling the centrifugal separation factor at 12000. After centrifugation, observe the state of the material in the centrifuge tube as a small amount of sedimentation.

[0050] Randomly select 40 respiratory-sensitive volunteers to participate in the clinical experiment. Among them, the volunteers are 3 - 7 years old, and the male-female ratio is 1:1. Among them, 20 people take 10 ml of placebo after three meals, and another 20 people take the boysenberry composition after three meals, and take it for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo is: 5 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 1 time.

[0051] Example 2

[0052] The preparation process of Example 2 is basically the same as that of Example 1. The difference is that when preparing the boysenberry composition, 10.0 g of microcrystalline cellulose and 15.0 g of pectin are added as thickeners.

[0053] Evaluation:

[0054] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at high speed for 10 minutes under the condition of controlling the centrifugal separation factor at 12000. After centrifugation, observe the state of the material in the centrifuge tube as an extremely small amount of sedimentation.

[0055] Randomly screen 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people take 10 ml of placebo after three meals, and another 20 people take the boysenberry composition after three meals for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo is: 6 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 2 times.

[0056] Example 3

[0057] The preparation process of Example 3 is basically the same as that of Example 1. The difference is that when preparing the boysenberry composition, 30.0 g of microcrystalline cellulose and 45.0 g of pectin are added as thickeners.

[0058] Evaluation:

[0059] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12,000. After centrifugation, observe the state of the material in the centrifuge tube and find that there is no sedimentation.

[0060] Randomly screen 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people take 10 ml of placebo after three meals, and another 20 people take the boysenberry composition after three meals for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo is: 4 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 1 time.

[0061] Example 4

[0062] The preparation process of Example 4 is basically the same as that of Example 1. The difference is that when preparing the boysenberry composition, the number of homogenization times is reduced to 3 times.

[0063] Evaluation:

[0064] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12,000. After centrifugation, observe the state of the material in the centrifuge tube and find that there is a small amount of sedimentation.

[0065] Randomly screen 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people take 10 ml of placebo after three meals, and another 20 people take the boysenberry composition after three meals for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo is: 4 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 1 time.

[0066] Example 5

[0067] The preparation process of Example 5 is basically the same as that of Example 1, except that the number of homogenization times is increased to 8 times when preparing the boysenberry composition.

[0068] Stability evaluation: The boysenberry composition was filled into a centrifuge tube, and after centrifugal sedimentation, it was centrifuged at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12000. After centrifugation, the material state in the centrifuge tube was observed to have no sedimentation.

[0069] Randomly select 40 respiratory-sensitive volunteers to participate in the clinical experiment. Among them, the volunteers are 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people took 10 ml of placebo after three meals, and the other 20 people took the boysenberry composition after three meals for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo was: 7 times, and the average number of monthly asthma attacks for those taking the boysenberry composition was: 1 time.

[0070] Example 6

[0071] The preparation process of Example 6 is basically the same as that of Example 1, except that the degassing vacuum degree is reduced to -0.08 MPa when preparing the boysenberry composition.

[0072] Evaluation:

[0073] Stability evaluation: The boysenberry composition was filled into a centrifuge tube, and after centrifugal sedimentation, it was centrifuged at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12000. After centrifugation, the material state in the centrifuge tube was observed to have a small amount of sedimentation.

[0074] Randomly select 40 respiratory-sensitive volunteers to participate in the clinical experiment. Among them, the volunteers are 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people took 10 ml of placebo after three meals, and the other 20 people took the boysenberry composition after three meals for a total of one month. Among them, the average number of monthly asthma attacks for those taking the placebo was: 5 times, and the average number of monthly asthma attacks for those taking the boysenberry composition was: 3 times.

[0075] Example 7

[0076] The preparation process of Example 7 is basically the same as that of Example 1, except that the degassing vacuum degree is increased to -0.095 MPa when preparing the boysenberry composition.

[0077] Evaluation:

[0078] Stability evaluation: The boysenberry composition was filled into a centrifuge tube, and after centrifugal sedimentation, it was centrifuged at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12000. After centrifugation, the material state in the centrifuge tube was observed to have a small amount of sedimentation.

[0079] Randomly select 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 - 7 years old, and the male - female ratio is 1:1. 20 of them take 10 ml of placebo after three meals, and the other 20 take the boysenberry composition after three meals for a total of one month. The average number of monthly asthma attacks for those taking the placebo is: 4 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 1 time.

[0080] Comparative Example 1

[0081] The preparation process of Comparative Example 1 is basically the same as that of Example 1. The difference is that small - molecule peptides are not added during the preparation of the boysenberry composition.

[0082] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12000. After centrifugation, observe the state of the material in the centrifuge tube, and there is a small amount of sedimentation.

[0083] Randomly select 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 - 7 years old, and the male - female ratio is 1:1. 20 of them take 10 ml of placebo after three meals, and the other 20 take the boysenberry composition after three meals for a total of one month. The average number of monthly asthma attacks for those taking the placebo is: 5 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 3 times.

[0084] Comparative Example 2

[0085] The preparation process of Comparative Example 2 is basically the same as that of Example 1. The difference is that herbal components other than apple juice are not added during the preparation of the boysenberry composition.

[0086] Evaluation:

[0087] Stability evaluation: Put the boysenberry composition into a centrifuge tube, and after centrifugal sedimentation, centrifuge at a high speed for 10 minutes under the condition of controlling the centrifugal separation factor of 12000. After centrifugation, observe the state of the material in the centrifuge tube, and there is no sedimentation.

[0088] Randomly select 40 volunteers with respiratory sensitivity to participate in the clinical trial. Among them, the age of the volunteers is 3 - 7 years old, and the male - female ratio is 1:1. 20 of them take 10 ml of placebo after three meals, and the other 20 take the boysenberry composition after three meals for a total of one month. The average number of monthly asthma attacks for those taking the placebo is: 4 times, and the average number of monthly asthma attacks for those taking the boysenberry composition is: 3 times.

[0089] Comparative Example 3

[0090] The preparation process of Comparative Example 3 is basically the same as that of Example 1. During the preparation of the boysenberry composition, homogenization is not carried out.

[0091] Evaluation:

[0092] Stability evaluation: The boysenberry composition was placed in a centrifuge tube and centrifugally sedimented. Under the condition of controlling the centrifugal separation factor of 12000, it was centrifuged at high speed for 10 minutes. After centrifugation, the state of the material in the centrifuge tube was observed to have a lot of sedimentation.

[0093] Randomly select 40 respiratory-sensitive volunteers to participate in the clinical trial. Among them, the age of the volunteers is 3 to 7 years old, and the male-female ratio is 1:1. Among them, 20 people took 10 ml of placebo after three meals, and another 20 people took the boysenberry composition after three meals for a total of one month. Among them, the average number of asthma attacks per month for those taking the placebo was 6 times, and the average number of asthma attacks per month for those taking the boysenberry composition was 1 time.

Claims

1. A boysenberry composition, characterized in that The composition comprises boysenberry concentrated juice, small molecule peptides and herbal components.

2. The boysenberry composition according to claim 1, characterized in that The mass ratio of the boysenberry concentrated juice, small molecule peptides and herbal components is 1:0.35-0.55:3.0-10.

0.

3. The boysenberry composition according to claim 1, characterized in that The small molecule peptides include bovine spleen peptide and albumin peptide; the mass ratio of the bovine spleen peptide to the albumin peptide is 1:0.01-0.

04.

4. The boysenberry composition according to claim 1, characterized in that The herbal component includes apple juice and at least one of tangerine peel, licorice, sophora japonica seed, emblica fruit, tangerine peel, almond, chrysanthemum, monk fruit and platycodon; the mass ratio of the apple juice to the other components of the herbal component except the apple juice is 1:0.005-0.

05.

5. The boysenberry composition according to claim 1, characterized in that The composition also includes a thickener; the mass ratio of the boysenberry concentrated juice to the thickener is 1:0-0.3; the thickener is selected from at least one of xanthan gum, pectin, guar gum, acetylated distarch phosphate, gum arabic, microcrystalline cellulose, and lecithin.

6. The composition according to any one of claims 1 to 5, characterized in that The preparation method of the composition comprises the following steps: (1) Fresh apples are washed, dried, peeled, cored, and squeezed to produce apple juice; (2) The herbal components except apple juice are crushed and sieved by a crusher to form fine powder of the herbal components; (3) adding apple juice, herbal component powder, and thickener to an emulsifying kettle, and turning on a high-speed shearing device for high-speed shearing to form a suspension; (4) The suspension is homogenized by a homogenizer multiple times to form a homogenous liquid; (5) the homogenized liquid is degassed by a degasser to form a degassed liquid; (6) Adding boysenberry concentrated juice and small molecule peptides to the degassed liquid under nitrogen protection, stirring and mixing, to form a boysenberry composition.

7. The preparation method according to claim 6, characterized in that: The mesh size of the sieve used in the sieving process of step (2) is 100 to 300 meshes.

8. The preparation method according to claim 6, characterized in that: The number of times of the multiple homogenization processes by the homogenizer in step (4) is 3 to 8 times; and the pressure of the homogenization process is 10 to 40 MPa.

9. The preparation method according to claim 6, characterized in that: The pressure of the degassing process of the degasser in step (5) is -0.08 to -0.095 MPa.

10. An application of a boysenberry composition, wherein the boysenberry composition is prepared by the preparation method according to any one of claims 6 to 9, characterized in that: The boysenberry composition is used to improve lung health.