Anti-hair-loss shampoo capable of effectively inhibiting bacteria and controlling oil and preparation method of anti-hair-loss shampoo

Abstract

The invention discloses an anti-hair loss shampoo capable of effectively inhibiting bacteria and controlling oil and a preparation method of the anti-hair loss shampoo, and belongs to the technical field of anti-hair loss shampoo. The anti-hair loss shampoo is prepared from the following components in percentage by weight: 0.2 to 0.5 percent of plant extract nano-liposome, 0.5 to 1.5 percent of surfactant, 0.5 to 1 percent of nitrilotriacetic acid, 0.2 to 0.8 percent of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 0.1 to 0.5 percent of D-panthenol, 0.5 to 1 percent of piroctone olamine salt, 1 to 5 percent of glycerol, 1 to 5 percent of 1, 3-butanediol, 0.4 to 0.8 percent of hyaluronic acid, 0.2 to 0.5 percent of preservative, 0.2 to 0.5 percent of essence, 0.5 to 1 percent of thickening agent and the balance of deionized water. 0.1-0.3% of tocopherol and the balance of water. According to the invention, a plurality of natural plant extracts with bacteriostatic, oil-control and anti-hair-loss effects are screened and are wrapped by using a nano-liposome technology, and other functional components are reasonably matched, so that the preparation of the efficient, stable and mild anti-hair-loss shampoo capable of effectively inhibiting bacteria and controlling oil is realized, the scalp environment is improved from multiple aspects, and the anti-hair-loss effect is improved. The hair loss problem is effectively reduced, and the requirements of people on anti-hair loss hair washing products are met.

Description

Technical Field

[0001] The invention belongs to the technical field of anti-hair loss shampoo, and in particular relates to an anti-hair loss shampoo with effective antibacterial and oil control and a preparation method thereof. Background Art

[0002] With the development of society, the accelerated pace of life and the influence of various factors such as the environment, the incidence of hair loss has increased year by year, and the demand for hair loss prevention and hair growth has increased day by day, which has become one of the important health issues that modern people are concerned about. Hair loss is often the result of the combined action of multiple factors, among which seborrheic dermatitis is one of the most common factors. The pathogenesis of seborrheic alopecia has not yet been fully clarified, and it is mainly related to genetic susceptibility, dysregulation of gonadal hormone secretion, local inflammatory response, etc. At present, there is still a lack of efficient and side-effect-free treatment methods for seborrheic alopecia. Common treatment methods mainly include hair transplantation, drug therapy, and the use of scalp care products, but surgical treatment has the disadvantages of large trauma, high cost, limited access to hair follicles, and possible inflammatory complications. Although drugs such as finasteride and minoxidil have therapeutic effects to a certain extent, their application is limited due to the long treatment cycle, which can easily lead to adverse reactions such as skin irritation, hirsutism, tachycardia, and sexual dysfunction. In contrast, scalp care products such as shampoo, as daily necessities that have the most contact with hair, are convenient to use and have relatively low costs in solving hair problems. Anti-hair loss shampoo, as a type of functional shampoo, has naturally become a current research hotspot.

[0003] However, although some shampoos on the market claim to have anti-hair loss effects, the actual effects are not good and they often fail to fundamentally solve the problem of hair loss. They are unstable in terms of oil control and may seem to reduce the oil secretion of the scalp in a short period of time, but the oil secretion will rebound soon, and the scalp cannot be effectively maintained in a refreshing state. In terms of antibacterial, many products cannot effectively inhibit the growth of harmful bacteria and fungi on the scalp, and it is difficult to improve the microecological environment of the scalp, resulting in persistent scalp inflammation problems, which in turn affects the healthy growth of hair. Moreover, due to poor stability and low bioavailability, the active ingredients in some anti-hair loss shampoos are difficult to fully play their due role. Some ingredients may even irritate the scalp, causing discomfort reactions such as itching, redness and swelling of the scalp, further aggravating the problem of hair loss. Summary of the invention

[0004] In view of the above situation, in order to overcome the defects of the prior art, the present invention screened a variety of natural plant extracts with antibacterial, oil-control and anti-hair loss effects, and encapsulated them using nanoliposome technology, while reasonably combining other functional ingredients to achieve the preparation of an efficient, stable and mild anti-bacterial and oil-control anti-hair loss shampoo, aiming to improve the scalp environment from multiple aspects, effectively reduce the problem of hair loss, and meet people's demand for anti-hair loss shampoo products.

[0005] To achieve the above object, the following technical solutions are adopted: The present invention provides an anti - hair - loss shampoo with effective antibacterial and oil - control properties, containing the following components in weight percentages:

[0006] Plant extract nano - liposomes 0.2 - 0.5%, surfactant 0.5 - 1.5%, nitrilotriacetic acid 0.5 - 1%, disodium EDTA 0.2 - 0.8%, D - panthenol 0.1 - 0.5%, piroctone olamine 0.5 - 1%, glycerol 1 - 5%, 1,3 - butanediol 1 - 5%, hyaluronic acid 0.4 - 0.8%, preservative 0.2 - 0.5%, essence 0.2 - 0.5%, thickener 0.5 - 1%, tocopherol 0.1 - 0.3%, and the balance is water.

[0007] Further, the plant extract nano - liposomes are prepared by the following steps:

[0008] S1. Dissolve soy lecithin and cholesterol in absolute ethanol to obtain a first - phase solution. Add Inonotus obliquus extract, Plukenetia volubilis extract, Drosera peltata extract, Parasenecio roborowskii extract, Platycladus orientalis extract, Astragalus membranaceus extract, Zingiber officinale root extract, and wheat bran extract into propylene glycol to obtain a second - phase solution. Mix hydrogenated castor oil, glycerol, and deionized water and heat to 70°C to obtain a third - phase solution;

[0009] S2. Mix the first - phase solution, the second - phase solution, and the third - phase solution, stir for 30 - 50 min, then remove ethanol under reduced pressure, and perform high - pressure homogenization to obtain plant extract nano - liposomes.

[0010] Further, the first - phase solution includes the following components in parts by weight: 5 - 10 parts of soy lecithin, 2 - 5 parts of cholesterol, and 50 - 80 parts of absolute ethanol.

[0011] Further, the second - phase solution includes the following components in parts by weight: 3 - 8 parts of Inonotus obliquus extract, 2 - 6 parts of Plukenetia volubilis extract, 1 - 4 parts of Drosera peltata extract, 2 - 5 parts of Parasenecio roborowskii extract, 4 - 9 parts of Platycladus orientalis extract, 3 - 7 parts of Astragalus membranaceus extract, 2 - 6 parts of Zingiber officinale root extract, 1 - 5 parts of wheat bran extract, and 30 - 60 parts of propylene glycol.

[0012] Inonotus obliquus extract: The scientific name of Inonotus obliquus is Inonotus obliquus, which is a medicinal fungus growing on birch trees. Its extract is rich in various bioactive components such as polysaccharides and triterpenoids. It has antioxidant effects, can scavenge free radicals in the body, and delay cell aging; it also has an immune - regulating function, can enhance the body's immunity, and help resist the invasion of external pathogens. In the shampoo, it may help improve the micro - ecological environment of the scalp, inhibit the growth of harmful bacteria, and at the same time provide nourishment for the scalp and promote scalp health.

[0013] Plukenetia volubilis extract: It contains rich unsaturated fatty acids, such as linolenic acid, linoleic acid, etc. These fatty acids have good moisturizing and hydrating effects on the skin and hair, can effectively prevent water loss, and keep the hair smooth and shiny. In addition, it also has certain antioxidant properties, can reduce the oxidative stress reaction of the scalp, and has a positive effect on maintaining the healthy state of the scalp.

[0014] Drosera extract: Its extract contains antibacterial and anti-inflammatory components. The Drosera extract can inhibit the growth of harmful bacteria and fungi on the scalp, reduce the scalp inflammatory reaction, and is helpful for improving problems such as scalp itching and dandruff. At the same time, it creates a healthy environment for the scalp, which is beneficial to the growth and stability of hair.

[0015] Parasenecio roborowskii extract: It has the functions of antibacterial and anti-inflammatory, can relieve scalp inflammation, and reduce hair loss caused by inflammation. At the same time, it may also provide nutrition for the scalp, promote scalp blood circulation, and enhance the vitality of hair follicles.

[0016] Platycladus orientalis extract: Its extract contains various active ingredients such as volatile oils and flavonoid compounds. It has the effects of cooling blood to stop bleeding and promoting hair growth. The Platycladus orientalis extract can penetrate deep into the hair follicles, nourish the hair roots, promote hair growth, and at the same time has a certain oil control effect, can regulate scalp oil secretion, improve the greasy condition of the scalp, and has a certain preventive and improvement effect on seborrheic alopecia.

[0017] Astragalus membranaceus extract: The Astragalus membranaceus extract contains various active ingredients such as astragalus polysaccharides, flavonoids, and amino acids, and has the effects of enhancing the immune function of the body and antioxidant. The Astragalus membranaceus extract can enhance the immunity of the scalp, resist the invasion of external pathogens, and at the same time provide nutrition for scalp cells, promote the metabolism of scalp cells, help maintain the health of the scalp, and reduce hair loss

[0018] Ginger root extract: Ginger root contains various active ingredients such as gingerol and curcumin. It has the effects of anti-inflammatory, antioxidant, and promoting blood circulation. The ginger root extract can stimulate scalp blood circulation, provide sufficient nutrition and oxygen for hair follicles, promote hair growth, and its anti-inflammatory effect can relieve scalp inflammation and reduce the production of dandruff, which has a positive effect on the healthy growth of hair.

[0019] Wheat bran extract: The wheat bran extract contains rich nutritional components such as dietary fiber, vitamins, and minerals. In shampoo, the wheat bran extract can provide various nutrients for the scalp, nourish scalp cells, and enhance the barrier function of the scalp.

[0020] Nitrilotriacetic acid and disodium EDTA: As chelating agents, they reduce the impact of metal ions in the shampoo on the stability of the product system, improve the stability and effectiveness of the shampoo, can undergo chelation reactions with metal ions in the shampoo, eliminate the adverse effects of these metal ions on the performance of the shampoo, and also help maintain the purity and color of the shampoo.

[0021] D-Panthenol: When applied to the skin, it is a deeply penetrating moisturizer that promotes wound healing by stimulating the growth of epidermal cells and has an anti-inflammatory effect. When applied to the hair, it has a long-lasting moisturizing function, can prevent hair from splitting and being damaged, increase hair density, and improve hair luster.

[0022] Piroctone olamine: It has strong antifungal and antibacterial activities, can inhibit the growth and reproduction of microorganisms such as Malassezia, effectively reduce dandruff and relieve scalp itching, can also regulate the balance of scalp oil secretion, make the hair fresh, is mild in nature and does not cause irritation, is friendly to the scalp and hair, and has strong chemical stability.

[0023] Glycerol: It is a colorless, transparent and viscous liquid, a relatively strong hygroscopic agent, and is widely used in cosmetic preparations. The concentrated solution has strong water absorption, absorbs the moisture of the epidermis and makes the skin feel irritating. The aqueous solution with a concentration lower than 50% by mass is mild, has an analgesic effect, and helps the healing of wounds.

[0024] 1,3-Butanediol: It is a colorless, odorless, transparent and viscous liquid, mainly used as a moisturizer in cosmetics, and can dissolve dirt and help the active ingredients penetrate.

[0025] Hyaluronic acid: It is one of the substances with the best moisturizing properties found in nature so far. Its moisturizing effect is 500 times that of glycerol. It can form a breathable film on the skin surface to prevent water from being lost through the epidermis. At the same time, it can also absorb water from the air to supplement water for the skin, making the skin stay moist for a long time.

[0026] Tocopherol: It has strong antioxidant properties, can scavenge free radicals in the hair and scalp, protect the hair structure, and prevent the aging of scalp cells; it can moisturize and form a film on the hair surface to lock water and enhance hydrophilicity; it can also promote hair growth, improve scalp blood circulation and regulate oil secretion, and supply energy to hair follicles; and it can stabilize the system in the formula, prevent the oxidation of other ingredients, extend the shelf life, and has good compatibility with each ingredient to jointly maintain hair health.

[0027] Furthermore, the third-phase solution comprises the following components in parts by weight: 3-7 parts of hydrogenated castor oil, 5-10 parts of glycerol, and 60-90 parts of deionized water.

[0028] Furthermore, the mass ratio of the first-phase solution, the second-phase solution, the third-phase solution and the buffer solution is 1: 1-2: 1-2: 0.2-0.5.

[0029] Further, the conditions for high-pressure homogenization are as follows: temperature 55 - 75°C, pressure 800 - 1000 bar, and homogenization is carried out three times.

[0030] Further, the surfactant is one or a combination of more than one of sodium lauryl polyether sulfate, ammonium lauryl polyether sulfate, sodium dodecyl sulfate, ammonium dodecyl sulfate, sodium dodecylbenzenesulfonate, coconut oil diethanolamide, coconut oil monoethanolamide, cocamidopropyl betaine, lauramidopropyl betaine, and lauryl alcohol amide propylamine oxide.

[0031] Further, the essence is one or a combination of more than one of lemon fragrance, rose fragrance, and chamomile fragrance.

[0032] Further, the thickener is one or a combination of two or more of sodium chloride, polyquaternium - 7, polyquaternium - 10, sodium alginate, casein, xanthan gum, and hydroxyethyl cellulose.

[0033] Further, the preservative is one of phenoxyethanol and DMDM hydantoin.

[0034] The present invention also provides a preparation method of an anti - hair - loss shampoo with effective antibacterial and oil - control functions, including the following steps: Slowly add the thickener to water, continuously stir until the thickener is uniformly dispersed in water to form a dispersion liquid. Then add nitrilotriacetic acid and disodium EDTA to the above - mentioned dispersion liquid, continue to stir to make them fully mixed evenly. Then heat to 70°C, add the surfactant. After that, maintain the system temperature at 70°C, add glycerol, 1,3 - butanediol, and hyaluronic acid in sequence, continuously stir until these components are completely melted to form a uniform mixed system, continue to keep warm for 20 min. Then add piroctone olamine to the system, and then slowly cool the system to 40°C, add tocopherol and stir evenly, then add plant extract nano - liposome, stir for 30 min. After the temperature drops to room temperature, add D - panthenol, preservative, and essence in sequence, continuously stir for 30 min. Discharge the finished product and store it in a suitable container, and obtain the anti - hair - loss shampoo through quality inspection and packaging.

[0035] The beneficial effects of the present invention are as follows: The core component of the present invention, the plant extract nano-liposome, integrates the essence of various plants such as Inonotus obliquus, Plukenetia volubilis, Drosera peltata, Parasenecio roborowskii, Platycladus orientalis, Astragalus membranaceus, Zingiber officinale root, wheat bran extract, etc., to form a unique nano-structure. It can not only effectively protect the plant active ingredients from being damaged by external factors and maintain their stability and activity, but also, due to its good biocompatibility with scalp cells, greatly improve the absorption efficiency of plant extracts in the scalp, enabling each component to play a more efficient role. For example, the antioxidant and immunomodulatory effects of Inonotus obliquus extract, the moisturizing and antioxidant properties of Plukenetia volubilis extract, the antibacterial and anti-inflammatory capabilities of Drosera peltata extract, the antibacterial, anti-inflammatory and blood circulation promoting effects of Parasenecio roborowskii extract, the effects of cooling blood and stopping bleeding and promoting hair growth of Platycladus orientalis extract, the immune enhancing and cell nutrition supply effects of Astragalus membranaceus extract, the anti-inflammatory and blood circulation promoting effects of Zingiber officinale root extract, and the nutritional supplement effect of wheat bran extract, etc., can all be fully exerted on the scalp, synergistically improving the scalp microecological environment, inhibiting the growth of harmful bacteria, reducing the inflammatory response, and creating a healthy scalp condition for hair growth. At the same time, the slow-release and controlled-release characteristics of the nano-liposome ensure that these active ingredients are slowly and continuously released during the shampooing process, prolonging their action time, allowing the scalp and hair to continuously benefit, reducing the risk of irritation that may be caused by the instantaneous contact of high-concentration ingredients with the scalp, and reducing side effects. In combination with the chelating effects of nitrilotriacetic acid and disodium EDTA on metal ions, the product stability is maintained; the moisturizing, anti-inflammatory and hair repair effects of D-panthenol; the powerful antifungal and antibacterial activities and sebum secretion regulating ability of piroctone olamine; the moisturizing and water-locking effects of glycerol, 1,3-butanediol and hyaluronic acid; the antioxidant, growth promoting and system stabilizing functions of tocopherol. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 It is the antibacterial performance evaluation result of a shampoo with effective antibacterial and oil control of the present invention;

[0037] Figure 2 It is the oil control performance evaluation result of a shampoo with effective antibacterial and oil control of the present invention;

[0038] Figure 3 It is the anti-hair loss performance evaluation result of a shampoo with effective antibacterial and oil control of the present invention.

[0039] The drawings are used to provide a further understanding of the present invention, and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention, and do not constitute a limitation to the present invention. DETAILED DESCRIPTION OF THE INVENTION

[0040] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention.

[0041] Unless otherwise defined, all professional and scientific terms used herein have the same meaning as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to the described content can be applied to the present invention. The preferred implementation methods and materials described herein are only for demonstration purposes and do not limit the content of this application.

[0042] The experimental methods in the following embodiments are all conventional methods unless otherwise specified. The test materials used in the following embodiments are all obtained from commercial channels unless otherwise specified.

[0043] Example 1

[0044] An anti - hair - loss shampoo with effective antibacterial and oil - control properties contains the following components in weight percentages:

[0045] Plant extract nano - liposomes 0.5%, surfactant 1.5%, nitrilotriacetic acid 1%, disodium EDTA 0.8%, D - panthenol 0.5%, piroctone olamine 1%, glycerol 5%, 1,3 - butanediol 5%, hyaluronic acid 0.8%, preservative 0.5%, essence 0.5%, thickener 1%, tocopherol 0.3%, and the rest is water.

[0046] The plant extract nano - liposomes are prepared through the following steps:

[0047] S1. Dissolve soy lecithin and cholesterol in absolute ethanol to obtain a first - phase solution. Add extracts of Inonotus obliquus, Plukenetia volubilis, Drosera peltata, Parasenecio roborowskii, Platycladus orientalis, Astragalus membranaceus, Zingiber officinale, and wheat bran into propylene glycol to obtain a second - phase solution. Mix hydrogenated castor oil, glycerol, and deionized water and heat to 70 °C to obtain a third - phase solution.

[0048] S2. Mix the first - phase solution, the second - phase solution, and the third - phase solution, stir for 30 min, then remove ethanol under reduced pressure, and perform high - pressure homogenization to obtain plant extract nano - liposomes.

[0049] The first-phase solution comprises components in the following parts by weight: 5 parts of soy lecithin, 2 parts of cholesterol, and 50 parts of absolute ethanol; the second-phase solution comprises components in the following parts by weight: 3 parts of Inonotus obliquus extract, 2 parts of Plukenetia volubilis extract, 1 part of Drosera extract, 2 parts of Parasenecio roborowskii extract, 4 parts of Platycladus orientalis extract, 3 parts of Astragalus membranaceus extract, 2 parts of ginger root extract, 1 part of wheat bran extract, and 30 parts of propylene glycol; the third-phase solution comprises components in the following parts by weight: 3 parts of hydrogenated castor oil, 5 parts of glycerol, and 60 parts of deionized water.

[0050] The mass ratio of the first-phase solution, the second-phase solution, the third-phase solution, and the buffer solution is 1:1:1:0.2.

[0051] The conditions for high-pressure homogenization are as follows: temperature 55°C, pressure 800 bar, and homogenization is carried out three times.

[0052] The surfactant is sodium lauryl polyether sulfate; the essence is lemon fragrance; the thickener is sodium chloride; the preservative is phenoxyethanol.

[0053] A preparation method of an anti-hair loss shampoo with effective antibacterial and oil control functions comprises the following steps: slowly add the thickener to water, continuously stir until the thickener is evenly dispersed in water to form a dispersion liquid, then add nitrilotriacetic acid and disodium EDTA to the above dispersion liquid, continue to stir to make them fully mixed evenly, then heat to 70°C, add the surfactant, and then maintain the system temperature at 70°C, add glycerol, 1,3-butanediol, and hyaluronic acid in sequence, continuously stir until these components are completely melted to form a uniform mixed system, continue to keep warm for 20 min, then add piroctone olamine to the system, then slowly cool the system to 40°C, add tocopherol and stir evenly, then add plant extract nano-liposomes, stir for 30 min, after the temperature drops to room temperature, add D-panthenol, preservative, and essence in sequence, continuously stir for 30 min, discharge the finished product and store it in a suitable container, and obtain the anti-hair loss shampoo through quality inspection and packaging.

[0054] Example 2

[0055] An anti-hair loss shampoo with effective antibacterial and oil control functions contains the following components in weight percentages:

[0056] 0.2% of plant extract nano-liposomes, 0.5% of surfactant, 0.5% of nitrilotriacetic acid, 0.2% of disodium EDTA, 0.1% of D-panthenol, 0.5% of piroctone olamine, 1% of glycerol, 1% of 1,3-butanediol, 0.4% of hyaluronic acid, 0.2% of preservative, 0.2% of essence, 0.5% of thickener, 0.1% of tocopherol, and the balance is water.

[0057] The plant extract nano-liposomes are prepared by the following steps:

[0058] S1. Dissolve soy lecithin and cholesterol in absolute ethanol to obtain a first-phase solution. Add the extracts of Inonotus obliquus, Plukenetia volubilis, Drosera peltata, Parasenecio roborowskii, Platycladus orientalis, Astragalus membranaceus, Zingiber officinale, and wheat bran into propylene glycol to obtain a second-phase solution. Mix hydrogenated castor oil, glycerol, and deionized water and heat to 70 °C to obtain a third-phase solution.

[0059] S2. Mix the first-phase solution, the second-phase solution, and the third-phase solution, stir for 50 min, then remove ethanol under reduced pressure, and perform high-pressure homogenization to obtain the plant extract nano-liposomes.

[0060] The first-phase solution comprises the following components in parts by weight: 10 parts of soy lecithin, 5 parts of cholesterol, and 80 parts of absolute ethanol; the second-phase solution comprises the following components in parts by weight: 8 parts of the extract of Inonotus obliquus, 6 parts of the extract of Plukenetia volubilis, 4 parts of the extract of Drosera peltata, 5 parts of the extract of Parasenecio roborowskii, 9 parts of the extract of Platycladus orientalis, 7 parts of the extract of Astragalus membranaceus, 6 parts of the extract of Zingiber officinale, 5 parts of the extract of wheat bran, and 60 parts of propylene glycol; the third-phase solution comprises the following components in parts by weight: 7 parts of hydrogenated castor oil, 10 parts of glycerol, and 90 parts of deionized water.

[0061] The mass ratio of the first-phase solution, the second-phase solution, the third-phase solution, and the buffer solution is 1:2:2:0.5.

[0062] The conditions of the high-pressure homogenization are: temperature 55 - 75 °C, pressure 800 - 1000 bar, and perform homogenization three times.

[0063] The surfactant is a combination of sodium lauryl polyether sulfate, ammonium lauryl polyether sulfate, and sodium dodecyl sulfate in a mass ratio of 1:1:1; the essence is rose fragrance; the thickener is polyquaternium-7; the preservative is DMDM hydantoin.

[0064] The preparation method of the anti-hair loss shampoo with effective antibacterial and oil control is the same as that of Example 1.

[0065] Example 3

[0066] An anti-hair loss shampoo with effective antibacterial and oil control contains the following components in weight percentages:

[0067] Plant extract nano-liposomes 0.35%, surfactant 1%, nitrilotriacetic acid 0.75%, disodium EDTA 0.5%, D-panthenol 0.3%, ethanolamine salt of piroctone olamine 0.75%, glycerol 3%, 1,3-butanediol 3%, hyaluronic acid 0.6%, preservative 0.3%, essence 0.3%, thickener 0.7%, tocopherol 0.2%, and the rest is water.

[0068] The nano-liposomes of the plant extract are prepared by the following steps:

[0069] S1. Dissolve soy lecithin and cholesterol in absolute ethanol to obtain a first-phase solution. Add extracts of Inonotus obliquus, Plukenetia volubilis, Drosera peltata, Parasenecio araiophyllus, Platycladus orientalis, Astragalus membranaceus, Zingiber officinale, and wheat bran extract into propylene glycol to obtain a second-phase solution. Mix hydrogenated castor oil, glycerol, and deionized water and heat to 70 °C to obtain a third-phase solution;

[0070] S2. Mix the first-phase solution, the second-phase solution, and the third-phase solution, stir for 40 min, then remove ethanol under reduced pressure, and perform high-pressure homogenization to obtain the nano-liposomes of the plant extract.

[0071] The first-phase solution comprises the following components in parts by weight: 6 parts of soy lecithin, 4 parts of cholesterol, and 50 - 860 parts of absolute ethanol; the second-phase solution comprises the following components in parts by weight: 5 parts of Inonotus obliquus extract, 3 parts of Plukenetia volubilis extract, 2 parts of Drosera peltata extract, 3 parts of Parasenecio araiophyllus extract, 5 parts of Platycladus orientalis extract, 6 parts of Astragalus membranaceus extract, 4 parts of Zingiber officinale extract, 4 parts of wheat bran extract, and 50 parts of propylene glycol; the third-phase solution comprises the following components in parts by weight: 6 parts of hydrogenated castor oil, 8 parts of glycerol, and 80 parts of deionized water.

[0072] The mass ratio of the first-phase solution, the second-phase solution, the third-phase solution, and the buffer solution is 1:1.2:1.5:0.3.

[0073] The conditions of the high-pressure homogenization are: temperature 60 °C, pressure 900 bar, and perform homogenization three times.

[0074] The surfactant is a combination of sodium lauryl polyether sulfate, ammonium lauryl polyether sulfate, sodium dodecyl sulfate, and coconut oil diethanolamide in a mass ratio of 1:2:1:0.5; the essence is a combination of lemon fragrance, rose fragrance, and chamomile fragrance in a mass ratio of 1:2:1; the thickener is a combination of sodium chloride, polyquaternium-7, casein, xanthan gum, and hydroxyethyl cellulose in a mass ratio of 1:2:1:0.5:1; the preservative is DMDM hydantoin.

[0075] The preparation method of the anti-hair loss shampoo with effective antibacterial and oil control is the same as that of Example 1.

[0076] Comparative Example 1

[0077] The difference between this comparative example and Example 3 is that the plant extract nano-liposomes are replaced with chaga extract, sacha inchi extract, sundew extract, Parasenecio roborowskii extract, Platycladus orientalis extract, Astragalus membranaceus extract, ginger root extract, and wheat bran extract, and the rest are the same as in Example 3 system.

[0078] Result analysis

[0079] Test Example 1

[0080] Antibacterial performance evaluation of shampoo

[0081] The antibacterial performance of the shampoo was evaluated according to the antibacterial performance test method for dissolving antibacterial (bacteriostatic) products in Appendix C of GB15979-2002 "Hygiene Standards for Disposable Sanitary Products", and the results are shown in Figure 1 .

[0082] Specifically, it includes the following steps:

[0083] (1) The product after 24-hour slant culture of Malassezia was washed with PBS to prepare a bacterial suspension.

[0084] (2) 100 μL of the bacterial suspension was added dropwise to each of the test samples and the control product. After mixing evenly, the timing program was started immediately, and they were allowed to act for 2 minutes, 5 minutes, 10 minutes, and 20 minutes respectively.

[0085] (3) Using sterile forceps, 0.5 mL of the sample was carefully put into a test tube containing 5 mL of PBS. After thorough shaking and mixing, appropriate dilution operations were carried out. Then, 0.5 mL was taken out and placed in a petri dish. 15 mL of nutrient agar medium cooled to 40 °C to 45 °C was poured, and the petri dish was rotated to make the medium evenly distributed. After the agar solidified, the plate was turned over and cultured at (35 ± 2) °C for 48 hours. Finally, the viable bacteria colony count was performed. The calculation method of the bacteriostatic rate is: (average colony count of the control sample - average colony count of the test sample) ÷ average colony count of the control sample × 100%.

[0086] From Figure 1As can be seen from the results, the antibacterial rates of the shampoo in Examples 1-3 against Malassezia were significantly higher than that in Comparative Example 1 after 2 minutes, 5 minutes, 10 minutes and 20 minutes of action. This is because the plant extract nano-liposomes in the examples integrate a variety of plant essences, such as components with antibacterial and anti-inflammatory effects like Drosera extract and Parasenecio roborowskii extract, which can more effectively inhibit the growth of harmful bacteria such as Malassezia. The unique structure of the nano-liposomes not only protects the plant active ingredients but also enhances their affinity with scalp cells, making the antibacterial components more easily absorbed by the scalp, thus showing strong antibacterial performance within a short action time. In Comparative Example 1, the plant extracts were not encapsulated by nano-liposomes, and the antibacterial effects of each plant extract could not be fully exerted, resulting in relatively weak antibacterial performance.

[0087] Test Example 2

[0088] Evaluation of the oil control performance of the shampoo

[0089] Use The initial oil content of the scalp of the test subjects was measured with an MB560 oil tester, and the products prepared in each example and comparative example of the present invention were used to wash the hair once a day. The oil content was measured at 20 days, 40 days and 60 days, and the oil change rate was recorded. The results are shown in Figure 2 .

[0090] From Figure 2 The results show that when using the shampoo prepared in Examples 1-3 of the present invention to wash the hair once a day, the oil change rate of the scalp after 20 days, 40 days and 60 days was significantly lower than that in Comparative Example 1. This is due to components such as Platycladus orientalis extract in the plant extract nano-liposomes, which have a certain oil control effect and can regulate the scalp oil secretion. At the same time, the slow-release characteristics of the nano-liposomes enable these oil control components to continuously act on the scalp, maintain the balance of scalp oil secretion, and keep the scalp fresh. In Comparative Example 1, the oil control effect of the plant extract lacks the protection and slow-release effect of the nano-liposomes and cannot effectively control the scalp oil secretion for a long time. Therefore, during long-term use, the oil control performance is not as good as that of Examples 1-3.

[0091] Test Example 3

[0092] Evaluation of the anti-hair loss performance of the shampoo

[0093] The test subjects used the products prepared in each example and comparative example of the present invention to wash their hair once a day. Before use and 4 weeks after use, the tester used a comb with the same specifications (tooth pitch 0.9-1.1 mm, tooth length 2.0-3.0 cm) and combed 60 times (30 times on each side) in the order from the front left to the back left and from the front right to the back right at a constant speed to collect the fallen hair and count it, and record the change rate of hair loss. The results are shown in Figure 3 .

[0094] It was found that after 4 weeks of use, the hair loss change rate of the shampoo in Examples 1-3 was significantly lower than that in Comparative Example 1. This is because the various plant extracts in the plant extract nano-liposomes act synergistically. For example, ginger root extract can stimulate scalp blood circulation, providing sufficient nutrition and oxygen for hair follicles; astragalus root extract can enhance scalp immunity and promote scalp cell metabolism; Parasenecio roborowskii extract can relieve scalp inflammation and reduce hair loss caused by inflammation, etc. These ingredients act better on scalp hair follicles through the efficient delivery of nano-liposomes, creating a healthy environment for hair growth, thereby effectively reducing hair loss. In Comparative Example 1, since the effects of the plant extracts were not fully exerted, the improvement effect on the hair loss problem was not as good as that in Examples 1-3.

[0095] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principles and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

[0096] The above describes the present invention and its embodiments. This description is not restrictive. What is shown in the drawings is only one of the embodiments of the present invention, and the actual application is not limited thereto. Generally speaking, if those of ordinary skill in the art are inspired by it and, without departing from the purpose of the present invention, design similar methods and embodiments to this technical solution without creative efforts, they should all fall within the protection scope of the present invention.

Claims

1. An anti-hair loss shampoo with effective antibacterial and oil-control properties, characterized by: Contains the following components in weight percentage: Plant extract nanoliposomes 0.2-0.5%, surfactant 0.5-1.5%, aminotriacetic acid 0.5-1%, disodium EDTA 0.2-0.8%, D-panthenol 0.1-0.5%, piroctone olamine salt 0.5-1%, glycerol 1-5%, 1,3-butylene glycol 1-5%, hyaluronic acid 0.4-0.8%, preservative 0.2-0.5%, flavor 0.2-0.5%, thickener 0.5-1%, tocopherol 0.1-0.3%, the rest is water; The plant extract nanoliposomes are prepared by the following steps: S1. Dissolve soybean lecithin and cholesterol in anhydrous ethanol to obtain a first phase solution, add Chaga extract, Astragalus extract, Drosera extract, Echinops extract, Platycladus orientalis leaf extract, Astragalus extract, Ginger root extract, and Wheat bran extract to propylene glycol to obtain a second phase solution, mix hydrogenated castor oil, glycerin, and deionized water and heat to 70° C. to obtain a third phase solution; S2. The first phase solution, the second phase solution and the third phase solution are mixed, stirred for 30-50 minutes, and then the ethanol is removed under reduced pressure, and high pressure homogenization is performed to obtain plant extract nanoliposomes.

2. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 1, characterized in that: The first phase solution comprises the following components in parts by weight: 5-10 parts of soybean lecithin, 2-5 parts of cholesterol and 50-80 parts of anhydrous ethanol; the second phase solution comprises the following components in parts by weight: 3-8 parts of Chaga extract, 2-6 parts of Asteraceae extract, 1-4 parts of Drosera extract, 2-5 parts of Echinops strychnifolia extract, 4-9 parts of Platycladus orientalis leaf extract, 3-7 parts of Astragalus extract, 2-6 parts of ginger root extract, 1-5 parts of wheat bran extract and 30-60 parts of propylene glycol; the third phase solution comprises the following components in parts by weight: 3-7 parts of hydrogenated castor oil, 5-10 parts of glycerin and 60-90 parts of deionized water.

3. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 2, characterized in that: The mass ratio of the first phase solution, the second phase solution, the third phase solution and the buffer solution is 1:1-2:1-2:0.2-0.

5.

4. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 3, characterized in that: The conditions of the high-pressure homogenization are: temperature 55-75° C., pressure 800-1000 bar, and homogenization is performed three times.

5. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 4, characterized in that: The surfactant is a combination of one or more of sodium laureth sulfate, ammonium laureth sulfate, sodium dodecyl sulfate, ammonium dodecyl sulfate, sodium dodecylbenzene sulfonate, coconut diethanolamide, coconut monoethanolamide, cocamidopropyl betaine, lauroamidopropyl betaine and lauryl amidopropyl amine oxide.

6. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 5, characterized in that: The essence is a combination of one or more of lemon fragrance, rose fragrance and chamomile fragrance.

7. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 6, characterized in that: The thickener is one or a combination of two or more of sodium chloride, polyquaternium-7, polyquaternium-10, sodium alginate, casein, xanthan gum and hydroxyethyl cellulose.

8. The effective antibacterial and oil-controlling anti-hair loss shampoo according to claim 7, characterized in that: The preservative is one of phenoxyethanol and DMDM ​​hydantoin.

9. A method for preparing the effective antibacterial and oil-controlling anti-hair loss shampoo according to any one of claims 1 to 8, characterized in that: The following steps are involved: The thickener is slowly added to the water, and the mixture is continuously stirred until the thickener is uniformly dispersed in the water to form a dispersion. Then, aminotriacetic acid and disodium EDTA are added to the dispersion, and the mixture is continuously stirred to be fully mixed. The mixture is then heated to 70°C, and a surfactant is added. The temperature of the system is then maintained at 70°C. Glycerol, 1,3-butylene glycol, and hyaluronic acid are sequentially added, and the mixture is continuously stirred until the ingredients are completely melted to form a uniform mixed system. The mixture is kept warm for 20 minutes, and piroctone ethanolamine salt is then added to the system. The system is then slowly cooled to 40°C, tocopherol is added and stirred uniformly, and plant extract nanoliposomes are added and stirred for 30 minutes. After the temperature drops to room temperature, D-panthenol, a preservative, and a flavor are sequentially added and stirred for 30 minutes. The finished product is discharged and stored in a suitable container. The anti-hair loss shampoo is obtained after quality inspection and packaging.

Images