Ablation device

Abstract

The application discloses an ablation device, which comprises a catheter, the catheter comprises a main body section and a liquid injection section, the liquid injection section is communicated with the distal end of the main body section, the distal end of the liquid injection section forms a catheter port, the maximum outer diameter of the liquid injection section is located at the proximal end, the outer diameter of the proximal end of the liquid injection section is less than or equal to the outer diameter of the distal end of the main body section, and a fixing structure is formed at the proximal end or the region close to the proximal end of the liquid injection section so as to fix the catheter. The chemical ablation device can sufficiently ablate target tissues such as plaques near the inlet of a blood vessel.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and more particularly to an ablation device. Background Technology

[0002] Chemical ablation involves bringing a chemical medium into full contact with the target tissue, allowing the chemical medium to penetrate and cause necrosis, thereby achieving the ablation effect. When performing chemical ablation on target tissues such as plaques in blood vessels, a chemical ablation catheter is typically used to inject the chemical ablation substance into the blood vessel for ablation. To ensure sufficient contact between the chemical ablation substance and the target tissue, the distal end of the chemical ablation catheter needs to be fixed inside the blood vessel.

[0003] Because the catheter needs to be fixed inside the blood vessel, existing devices require the catheter orifice of the chemical ablation catheter to be positioned deeper into the vessel, or a balloon to be placed at the distal end of the catheter, which is then inflated to fix the chemical ablation catheter inside the vessel. However, if the catheter orifice is too deep into the vessel, it will be far from the vessel inlet, and the chemical ablation substance cannot diffuse sufficiently to the vessel wall near the vessel inlet, resulting in incomplete ablation. Furthermore, the balloon will completely prevent the chemical ablation substance from diffusing into the vessel towards the proximal side of the balloon, leading to incomplete ablation of plaques located on the proximal side of the balloon within the vessel. Summary of the Invention

[0004] The technical problem to be solved by the present invention is that the chemical ablation substance injected into the blood vessel from the catheter port cannot diffuse sufficiently to the blood vessel inlet. In view of the defects of the prior art, an ablation device is provided.

[0005] The technical problem solved by this invention is achieved through the following technical solution:

[0006] The first aspect of the present invention provides an ablation device, the ablation device including a catheter, the catheter including a main body segment and an injection segment, the injection segment communicating with the distal end of the main body segment, the distal end of the injection segment forming a catheter orifice, wherein the maximum outer diameter of the injection segment is located on the proximal side, the outer diameter of the proximal end of the injection segment is less than or equal to the outer diameter of the distal end of the main body segment, so that the proximal end of the injection segment or the area near the proximal end forms a fixing structure to fix the catheter.

[0007] In some embodiments of the present invention, the injection section includes an injection portion and a transition portion, the proximal end of the transition portion is connected to the distal end of the main body section, the distal end of the transition portion is connected to the proximal end of the injection portion, and the catheter orifice is formed at the distal end of the injection portion; wherein, the fixing structure is disposed in the transition portion, the maximum outer diameter of the transition portion is less than or equal to the outer diameter of the main body section, and / or, the minimum outer diameter of the transition portion is greater than or equal to the outer diameter of the injection portion.

[0008] In some embodiments of the present invention, the outer diameter of the transition portion gradually increases from the distal end to the proximal end; and / or the outer peripheral surface of the transition portion is recessed into the interior of the transition portion along the radial direction of the conduit.

[0009] In some embodiments of the present invention, the ablation device further includes: a support device disposed in the injection section, at least a portion of the support device being movable relative to the injection section to allow the support device to switch between a first state and a second state; the maximum outer diameter of the support device in the first state is smaller than the maximum outer diameter of the support device in the second state, and in the first state, the maximum outer diameter of the support device is smaller than or equal to the outer diameter of the main body section; the support device has at least one fluid channel in the second state, the fluid channel penetrating the proximal and distal ends of the support device.

[0010] In some embodiments of the present invention, the support device includes at least one elastic element, and the ablation device further includes a mating element disposed on the catheter in a manner movable along the axial direction of the catheter. The mating element cooperates with the elastic element to control the deformation of the elastic element.

[0011] In some embodiments of the present invention, the support device includes a self-expanding mesh element, which is sleeved outside the injection section and connected to the outer peripheral surface of the injection section, and the mesh openings of the mesh element form the fluid channel; the mating component is an outer sheath tube, which is sleeved outside the support device and the conduit.

[0012] In some embodiments of the present invention, the distal end of the conduit is provided with multiple cantilever arms, which are arranged sequentially at intervals along the circumferential direction of the conduit. The interior of each cantilever arm is hollow to form a first receiving channel. The conduit is provided with a second receiving channel for each of the first receiving channels, and the distal end of the second receiving channel communicates with the first receiving channel. The support device includes multiple first elastic elements, and each of the second receiving channels is provided with a first elastic element. The first elastic element is movable between the second receiving channel and the first receiving channel. In the first state, the first elastic element is located in the second receiving channel. In the second state, the first elastic element is located in the first receiving channel. The radial extension of the first elastic element in the first state is less than the radial extension of the first elastic element in the second state. In the second state, the gap between any two adjacent first elastic elements forms the fluid channel. The distal end of the mating member is connected to the proximal end of the first elastic element and is used to push the first elastic element to move from the second receiving channel to the first receiving channel to generate the second state.

[0013] In some embodiments of the present invention, the support device includes: a first support ring sleeved on the outside of the injection section; a second support ring sleeved on the outside of the injection section and spaced apart from the first support ring along the axial direction of the conduit; a plurality of second elastic members, the plurality of second elastic members being sequentially spaced apart along the circumference of the conduit, and the two ends of the second elastic members being respectively connected to the first support ring and the second support ring; wherein, at least one of the first support ring and the second support ring is movable relative to the injection section along the axial direction of the conduit, the radial extension of the second elastic member in the first state is less than the radial extension of the second elastic member in the second state, in the second state, the first support ring and the second support ring are close to each other, and the gap between any two adjacent second elastic members forms the fluid channel; the mating member is configured as an outer sheath, the outer sheath being sleeved on the support device and the conduit.

[0014] In some embodiments of the present invention, the outer peripheral surface of the injection part is provided with a plurality of injection holes.

[0015] In some embodiments of the present invention, a plurality of injection holes are arranged at intervals along the axial direction of the conduit to form multiple groups of injection holes, each group having at least one injection hole; wherein, from the distal end to the proximal end, the number of injection holes in each group increases sequentially and the inner diameter of the injection holes decreases sequentially.

[0016] According to the ablation device proposed above, the maximum outer diameter of the injection segment is located at the proximal end. The outer diameter of the proximal end of the injection segment is less than or equal to the outer diameter of the distal end of the main body segment, so that the proximal end or the area near the proximal end of the injection segment forms a fixed structure to fix the catheter, allowing the injection segment to extend into the blood vessel. The fixed structure formed at the proximal end or the area near the proximal end of the injection segment can fix the catheter at the entrance of the blood vessel. The outer diameter of at least the distal and middle parts of the injection segment is small, so that a gap is created between the injection segment and the inner wall of the blood vessel. The chemical ablation substance injected into the blood vessel from the catheter orifice can diffuse to the proximal side of the blood vessel through the gap, so as to facilitate the full ablation of target tissues such as plaques near the entrance of the blood vessel. Attached Figure Description

[0017] The present invention will be further described below with reference to the accompanying drawings and embodiments. In the accompanying drawings:

[0018] Figure 1 A schematic diagram of the structure of an ablation device according to an embodiment of the present invention is shown;

[0019] Figure 2 A partial cross-sectional structural schematic diagram of a catheter according to an embodiment of the present invention is shown;

[0020] Figure 3A schematic diagram of the distal end of the catheter according to an embodiment of the present invention is shown;

[0021] Figure 4 A partial cross-sectional structural schematic diagram of a catheter according to an embodiment of the present invention is shown;

[0022] Figure 5 A partial cross-sectional structural schematic diagram of the conduit and support device according to an embodiment of the present invention is shown;

[0023] Figure 6 A schematic diagram of the cross-sectional structure of the conduit and the support device in a first state is shown as an embodiment of the present invention.

[0024] Figure 7 The diagram shows a guide tube in a second state and a partial cross-sectional structural schematic of the support device according to an embodiment of the present invention.

[0025] Figure 8 A schematic diagram of the structure of multiple cantilever arms in a first state of a support device according to an embodiment of the present invention is shown;

[0026] Figure 9 A schematic diagram of the structure of multiple cantilever arms of a support device in a second state according to an embodiment of the present invention is shown;

[0027] Figure 10 A schematic diagram of the conduit, support device, and mating parts in a second state is shown according to an embodiment of the present invention.

[0028] Figure 11 A schematic diagram of the structure of the conduit, the support device, and the mating parts in a first state is shown according to an embodiment of the present invention.

[0029] Figure 12 A schematic cross-sectional view of the catheter, support device, and blood vessel in a second state is shown according to an embodiment of the present invention.

[0030] Figure 13 A schematic diagram of an ablation device for intervention in a blood vessel according to an embodiment of the present invention is shown;

[0031] Figure 14 A schematic diagram of an ablation device for intervention in a blood vessel according to an embodiment of the present invention is shown;

[0032] Figure 15 A schematic diagram of an ablation device for intervention in a blood vessel according to an embodiment of the present invention is shown.

[0033] The markings in the attached diagram are as follows:

[0034] 100. Ablation equipment;

[0035] 10. Catheter; 101. Catheter orifice; 102. Cantilever; 1021. First receiving channel; 103. Second receiving channel;

[0036] 11. Main body section; 12. Injection section; 121. Injection part; 122. Transition part; 1211. Injection hole; 111. Fixing structure;

[0037] 20. Support device; 201. Fluid channel; 22. First elastic element; 23. First support ring; 24. Second support ring; 25. Second elastic element; 202. Mesh element; 2021. Inner ring mesh surface; 2022. Outer ring mesh surface;

[0038] 30. Mating component; 31. Outer sheath tube; 32. Push rod;

[0039] 40. Luer joint;

[0040] 200, blood vessels; 300, blood vessels. Detailed Implementation

[0041] To provide a clearer understanding of the technical features, objectives, and effects of the present invention, specific embodiments of the present invention will now be described in detail with reference to the accompanying drawings.

[0042] Exemplary embodiments of the present disclosure will now be described in more detail with reference to the accompanying drawings. While exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure may be implemented in various forms and should not be limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art.

[0043] It should be understood that the terminology used herein is for the purpose of describing particular exemplary embodiments only and is not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms “a,” “an,” and “described” as used herein may also include the plural forms. The terms “comprising,” “including,” “containing,” and “having” are inclusive and therefore indicate the presence of the stated features, steps, operations, elements, and / or components, but do not exclude the presence or addition of one or more other features, steps, operations, elements, components, and / or combinations thereof. The method steps, processes, and operations described herein are not construed as requiring them to be performed in a particular order described or illustrated unless the order of performance is explicitly indicated. It should also be understood that additional or alternative steps may be used.

[0044] Although terms such as first, second, third, etc., may be used in this document to describe multiple elements, components, regions, layers, and / or segments, these elements, components, regions, layers, and / or segments should not be limited by these terms. These terms may be used only to distinguish one element, component, region, layer, or segment from another. Unless the context clearly indicates otherwise, terms such as "first," "second," and other numerical terms used herein do not imply order or sequence. Therefore, the first element, component, region, layer, or segment discussed below may be referred to as the second element, component, region, layer, or segment without departing from the teachings of the exemplary embodiments.

[0045] For ease of description, spatial relative terms may be used in the text to describe the relationship of one element or feature relative to another element or feature, as shown in the figure. These relative terms include, for example, "inside," "outside," "middle," "outer," "below," "below," "above," "over," etc. Such spatial relative terms are intended to include different orientations of the device in use or operation, other than those depicted in the figure. For example, if the device in the figure is flipped, an element described as "below other elements or features" or "below other elements or features" would subsequently be oriented as "above other elements or features" or "above other elements or features." Therefore, the example term "below" can include both upper and lower orientations. The device may be otherwise oriented (rotated 90 degrees or in other directions), and the spatial relative descriptors used in the text will be interpreted accordingly.

[0046] It should be noted that the terms "distal" and "proximal" are used as directional terms, which are commonly used in the field of interventional medical devices. "Distal" refers to the end furthest from the operator during the procedure, while "proximal" refers to the end closest to the operator. Axial direction refers to the direction parallel to the line connecting the center of the distal and proximal ends of the medical device; radial direction refers to the direction perpendicular to the aforementioned axial direction.

[0047] like Figure 1 and Figure 2 Combination Figure 13 As shown, according to an embodiment of the present invention, an ablation device 100 is provided. The ablation device 100 includes a catheter 10, which includes a main body segment 11 and an injection segment 12. Both the main body segment 11 and the injection segment 12 are hollow tubular components. The distal end of the injection segment 12 forms a catheter port 101, and a chemical ablation substance is injected into the interior of a blood vessel 300 through the catheter port 101. In the embodiments of the present invention, the blood vessel 300 can be a vein or an artery. In one embodiment, the blood vessel 300 can be a coronary vein, and more specifically, the coronary vein can be a Marshall vein.

[0048] In this embodiment, the maximum outer diameter of the injection segment 12 is located on the proximal side, and the outer diameter of the proximal end of the injection segment 12 is less than or equal to the outer diameter of the distal end of the main body segment 11, so that the proximal end or the area near the proximal end of the injection segment 12 forms a fixing structure 111 to fix the catheter 10. In this embodiment, the outer diameter of the main body segment 11 is greater than or equal to the inner diameter of the inlet of the blood vessel 300, the maximum outer diameter of the injection segment 12 is located on the proximal end, the outer diameter of the proximal end of the injection segment 12 is less than or equal to the outer diameter of the distal end of the main body segment 11, and the outer diameter of at least the distal and middle portions of the injection segment 12 is less than the inner diameter of the blood vessel 300. When the injection segment 12 extends into the blood vessel 300, the main body segment 11 is located outside the blood vessel 300, and the catheter 10 can be fixed at the inlet position of the blood vessel 300 by the fixing structure 111. It should also be noted that the fixing structure 111 also serves to block the inlet of the blood vessel 300, preventing the chemical ablation substance from flowing out of the blood vessel 300 through the inlet, thus allowing the chemical ablation substance to fully contact the target tissues such as plaques within the blood vessel 300 and improving the ablation effect. Because the outer diameter of at least the distal and intermediate portions of the injection segment 12 is relatively small, a gap exists between the injection segment 12 and the inner wall of the blood vessel 300. The chemical ablation substance injected into the blood vessel 300 through the catheter port 101 can diffuse towards the proximal side of the blood vessel 300 through the gap between the injection segment 12 and the inner wall of the blood vessel 300, facilitating the full ablation of target tissues such as plaques near the inlet of the blood vessel 300.

[0049] In some embodiments of the present invention, please refer to Figure 2 and Figure 13 As shown, the injection section 12 includes an injection portion 121 and a transition portion 122 that are connected to each other. Specifically, the proximal end of the transition portion 122 is connected to the distal end of the main body section 11, and the distal end of the transition portion 122 is connected to the proximal end of the injection portion 121. The distal end of the injection portion 121 forms a catheter port 101, through which the chemical ablation substance is injected into the blood vessel 300. The maximum outer diameter of the transition portion 122 is less than or equal to the outer diameter of the main body section 11, and / or the minimum outer diameter of the transition portion 122 is greater than or equal to the outer diameter of the injection portion 121.

[0050] The outer diameter of the transition section 122 gradually changes along the axial direction of the catheter 10, decreasing from the proximal end to the distal end. The maximum outer diameter of the injection section 12 is located in the transition section 122, thereby forming a fixed structure 111 on the transition section 122. When the injection section 121 enters the blood vessel 300, the transition section 122 is fixed at the entrance of the blood vessel 300. The transition section 122 adopts a variable diameter structure, with its outer diameter gradually decreasing from the proximal end to the distal end, so that the transition section 122 contacts the inner wall of the blood vessel at the entrance of the blood vessel 300. Inside the blood vessel 300, due to the gradual decrease in the outer diameter of the transition section 122, a gap is generated between the transition section 122 and the inner wall of the blood vessel 300, allowing the chemical ablation substance injected into the blood vessel 300 from the catheter port 101 to diffuse towards the proximal side of the blood vessel 300 through the gap, thereby facilitating the thorough ablation of target tissues such as plaques on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0051] In some implementation methods, please refer to Figure 5 , Figure 6 , Figure 10 and Figure 12 As shown, the ablation device 100 also includes a support device 20, which is disposed in the injection section 12. At least a portion of the support device 20 is movable relative to the injection section 12, allowing the support device 20 to switch between a first state and a second state. In the first state, the maximum outer diameter of the support device 20 is smaller than the maximum outer diameter of the support device 20 in the second state. In the first state, the maximum outer diameter of the support device 20 is less than or equal to the outer diameter of the main body section 11. Specifically, during the insertion of the catheter 10 into the blood vessel 300, the support device 20 maintains the first state, ensuring that its maximum outer diameter is less than or equal to the outer diameter of the main body section 11, facilitating the smooth passage of the support device 20 through the blood vessel 200 to the blood vessel 300. When the support device 20 extends into the blood vessel 300, it maintains the second state, where its maximum outer diameter is equal to or slightly larger than the inner diameter of the blood vessel 300, allowing the support device 20 to be supported and fixed within the blood vessel 300. In conjunction with... Figure 13 Blood vessels 200 and 300 are interconnected. In one embodiment, blood vessel 200 can be a main blood vessel, and blood vessel 300 can be a branch blood vessel branching off from the main blood vessel.

[0052] It should be noted that the support device 20 is provided to assist in the fixation of the catheter. When the inner diameter of the target vessel is greater than the maximum outer diameter of the injection section, the outer diameter of the fixation structure 111 on the injection section is insufficient to achieve fixation. In this case, the support device 20 can assist the fixation structure on the catheter in further increasing the outer diameter of the fixation structure for fixation. When the inner diameter of the target vessel is at least smaller than the maximum outer diameter of the injection section, the fixation structure on the injection section can achieve fixation. In this case, the support device 20 is squeezed between the injection section and the vessel wall. The support device 20 cannot change from the first state to the second state, but it can still increase a certain degree of anchoring. Alternatively, the support device 20 can be located at the distal or middle region of the injection section. The support device 20 serves as a secondary fixation structure, and the fixation structure 111 serves as the primary fixation structure. The fixation structure 111 is still located at the orifice of the target vessel, while the support device 20 extends into the interior of the target vessel, thereby enhancing the anchoring of the catheter 10.

[0053] Therefore, the support device 20 can flexibly adapt to blood vessels of different sizes, thereby fixing the catheter 10 at the target blood vessel opening. In one embodiment, the support device 20 may not be provided, and a catheter of appropriate size can be selected by measuring the inner diameter of the target blood vessel opening before delivering the ablation device. To better illustrate the relevant structure, the support device 20 mentioned in the following specific embodiments (e.g., Embodiments 2 to 4) is described in the case where the inner diameter of the target blood vessel is greater than the maximum outer diameter of the injection section, and the support device 20 can switch from a first state to a second state.

[0054] The support device 20 has at least one fluid channel 201 in at least the second state, the fluid channel 201 extending through the proximal and distal ends of the support device 20. After the catheter port 101 injects the chemical ablation substance into the blood vessel 300, the chemical ablation substance can diffuse from the distal side of the support device 20 to the proximal side of the support device 20 through the fluid channel 201, so that the chemical ablation substance can diffuse to the entrance of the blood vessel 300, so as to facilitate the sufficient ablation of target tissues such as plaques on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0055] It should be noted that the fluid channel 201 can be a tubular channel extending along the axial direction of the conduit 10, with openings formed only at the proximal or distal end of the support device 20 for the chemical ablation material to flow in or out. Alternatively, the fluid channel 201 can also be in the shape of a groove, with both ends extending to the proximal and distal ends of the support device 20, respectively. Alternatively, the fluid channel 201 can also be other irregular shapes, as long as it allows the chemical ablation material to flow from one side of the proximal end of the support device 20 to the other side of the distal end of the support device 20.

[0056] In some embodiments, the fluid channel 201 is independent of the state of the support device 20. Regardless of whether the support device 20 is in the first state or the second state, the support device 20 is always provided with a flow channel that runs through its proximal and distal ends.

[0057] In some embodiments, when the support device 20 changes from a first state to a second state through deformation, a groove-like structure is formed on the outer contour of the support device 20, thereby forming a fluid channel 201.

[0058] The support device 20 may be a balloon (not shown) capable of changing shape, or the support device 20 may be a device with at least one elastic element that achieves the transition between the first state and the second state through elastic deformation.

[0059] For example, when the support device 20 is a balloon, the balloon structure can be configured as an irregularly shaped balloon (not shown in the figure). After the injection section 12 extends into the blood vessel 300, the balloon is inflated, causing it to expand and deform to a second state, thereby fixing the injection section 12 within the blood vessel 300. Furthermore, the outer peripheral surface of the balloon forms multiple groove structures extending axially along the catheter 10. These groove structures penetrate the proximal and distal ends of the balloon, and each groove structure serves as a fluid channel 201. Chemical ablation substances injected into the blood vessel 300 through the catheter port 101 can diffuse towards the entrance of the blood vessel 300 through the fluid channel 201, thereby fully ablating target tissues such as plaques on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0060] In some implementation methods, please refer to Figure 5 , Figure 6 and Figure 10 As shown, the support device 20 includes at least one elastic element, which allows the support device 20 to switch between a first state and a second state through elastic deformation. Furthermore, the ablation device 100 also includes a mating member 30, which is disposed on the catheter 10 in a manner movable along the axial direction of the catheter 10. The mating member 30 engages with the elastic element to deform the elastic element, thereby allowing the support device 20 to switch between the first state and the second state.

[0061] In this embodiment, the elastic element is deformed by manipulating the mating member 30 to specifically control the state of the support device 20. During the intervention of the ablation device 100 into the blood vessel 300, the support device 20 is kept in a first state to facilitate its smooth passage through the blood vessel 200 into the blood vessel 300, allowing the injection section 12 and the support device 20 to be inserted into the blood vessel 300. Then, the elastic element is deformed by manipulating the mating member 30, thereby placing the support device 20 in a second state, fixing the injection section 12 within the blood vessel 300.

[0062] It should be noted that the support device 20 can be configured into various different structural forms according to actual needs. The technical solution of the present invention will be further described in detail below with reference to specific embodiments.

[0063] Example 1

[0064] In this embodiment, combined with Figure 1 , Figure 2 and Figure 13 As shown, the ablation device 100 includes a conduit 10, which includes a main body section 11 and an injection section 12. Both the main body section 11 and the injection section 12 are hollow tubular components. The injection section 12 includes an injection portion 121 and a transition portion 122 that are connected to each other. The proximal end of the transition portion 122 is connected to the distal end of the main body section 11, and the distal end of the transition portion 122 is connected to the proximal end of the injection portion 121. The distal end of the injection portion 121 forms a conduit opening 101.

[0065] The maximum outer diameter of the injection section 12 is located at the transition section 122, thereby forming a fixed structure 111 on the transition section 122. The outer diameter of the transition section 122 gradually changes along the axial direction of the conduit 10, and the outer diameter of the injection section 121 is at least no greater than the minimum outer diameter of the transition section 122. The outer diameter of the transition section 122 gradually decreases from the proximal end to the distal end.

[0066] like Figure 13 As shown, when the injection section 121 enters the blood vessel 300, the transition section 122 is fixed at the entrance of the blood vessel 300. The transition section 122 adopts a variable diameter structure, and the outer diameter of the transition section 122 gradually decreases from the proximal end to the distal end, so that the transition section 122 and the entrance of the blood vessel 300 come into contact with the inner wall of the blood vessel. Inside the blood vessel 300, as the outer diameter of the transition section 122 gradually decreases, a gap is generated between the transition section 122 and the inner wall of the blood vessel 300, so that the chemical ablation substance injected into the blood vessel 300 from the catheter port 101 can diffuse to the proximal side of the blood vessel 300 through the gap, so as to fully ablate the target tissues such as plaques on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0067] The length of the transition portion 122 along the axial direction of the conduit 10 is set to a range of 1 mm to 4 mm.

[0068] In some implementations, such as Figure 3 As shown, the outer peripheral surface of the transition portion 122 is recessed into the interior of the transition portion 122 along the radial direction of the catheter 10, forming a concave portion on the outer peripheral surface of the transition portion 122. This increases the gap between the outer peripheral surface of the transition portion 122 and the inner wall of the blood vessel 300, facilitating the entry of more chemical ablation agent into the periphery of the catheter orifice 101 and diffusion into the gap between the outer peripheral surface of the transition portion 122 and the inner wall of the blood vessel 300, thereby ablating plaques and improving ablation efficiency.

[0069] like Figure 1 As shown, the proximal end of the catheter 10 is provided with a Luer connector 40, which facilitates the connection of external equipment with the catheter 10 to supply chemical ablation material.

[0070] Example 2

[0071] The differences between Embodiment 2 and Embodiment 1 will be described below. The similarities or similarities between Embodiment 2 and Embodiment 1 will not be repeated here.

[0072] In this embodiment, as Figure 5 and Figure 14 As shown, the ablation device 100 includes a catheter 10, a support device 20, and a mating component 30. The catheter 10 includes a main body section 11 and an injection section 12 that are connected to each other. Both the main body section 11 and the injection section 12 are hollow tubular components, and the distal end of the injection section 12 forms a catheter port 101.

[0073] The support device 20 is configured as a self-expanding mesh 202, which is annular and sleeved around the injection section 12. The mesh 202 includes an inner annular mesh surface 2021 and an outer annular mesh surface 2022. The inner annular mesh surface is connected to the outer peripheral surface of the injection section 12, either through surface connection or point connection. The mating component 30 is an outer sheath tube 31 (see...). Figure 10 and Figure 11 The outer sheath 31 is fitted over the mesh 202 and the catheter 10. During the intervention of the ablation device 100 into the blood vessel 300, the outer sheath 31 is fitted over the mesh 202 and the catheter 10. The mesh 202 is in a first state under the constraint of the inner wall of the outer sheath 31. When the injection section 12 enters the blood vessel 300, it pulls the outer sheath 31 to move towards the proximal side relative to the catheter 10, so that the mesh 202 gradually comes out of the outer sheath 31. The mesh 202 expands to a second state, thereby fixing the injection section 12 inside the blood vessel 300.

[0074] The mesh of the mesh 202 forms a fluid channel 201, through which the chemical ablation substance injected into the blood vessel 300 from the catheter port 101 can diffuse to the proximal side through the mesh, fully ablating the target tissue such as plaque on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0075] The mesh component 202 reduces the area of ​​obstruction to the inner wall of the blood vessel 300, allowing the chemical ablation material to make more sufficient contact with the plaque on the inner wall of the blood vessel 300, thereby improving the ablation rate.

[0076] In this embodiment, the mesh 202 is sleeved outside the transition portion 122. When the inner diameter of the blood vessel 300 is larger than the maximum outer diameter of the transition portion 122, the outer diameter of the fixing structure 111 on the transition portion 122 is insufficient to achieve the fixing effect. In this case, the mesh 202 can assist the fixing structure 111 on the catheter in further increasing the outer diameter of the fixing structure 111 for fixing. Alternatively, the mesh 202 can also be sleeved outside the injection portion 121, with the mesh 202 serving as a secondary fixing structure and the fixing structure 111 serving as the primary fixing structure. The fixing structure 111 is still located at the opening of the blood vessel 300, while the mesh 202 extends into the interior of the blood vessel 300, thereby enhancing the anchoring of the catheter 10.

[0077] Example 3

[0078] The differences between Embodiment 3 and Embodiment 1 will be described below. The similarities or similarities between Embodiment 3 and Embodiment 1 will not be repeated here.

[0079] In this embodiment, as Figures 6 to 9 As shown, the distal end of the conduit 10 is provided with multiple cantilever 102, and the multiple cantilever 102 are arranged sequentially at intervals along the circumferential direction of the conduit 10. The interior of the cantilever 102 is hollow to form a first receiving channel 1021. The conduit 10 is provided with a second receiving channel 103 corresponding to each first receiving channel 1021. The distal end of the second receiving channel 103 is connected to the first receiving channel 1021.

[0080] The support device 20 includes multiple first elastic elements 22, with one first elastic element 22 disposed within each second receiving channel 103. The first elastic elements 22 are movable between the second receiving channel 103 and the first receiving channel 1021. Specifically, when the first elastic element 22 is located in the second receiving channel 103, its radial extension is relatively small due to the constraint of the second receiving channel 103, since the second receiving channel 103 is located within the catheter 10. When the first elastic element 22 is located in the first receiving channel 1021, it extends radially under its own elastic force, causing the cantilever 102 to extend radially, making the multiple cantilever 102 flare outwards in a trumpet shape along the radial direction of the catheter 10, thus fixing the injection section 12 within the blood vessel 300. In this embodiment, the first elastic element 22 is rod-shaped; when not subjected to external force, it is a bent rod shape, and under the constraint of the second receiving channel 103, it becomes a straight rod shape.

[0081] In some embodiments, the first elastic element 22 is cylindrical, zigzag, or curved. In other embodiments, the first elastic element 22 may also be configured as a rod-shaped element with a rectangular cross-section.

[0082] The mating component 30 consists of multiple push rods 32, each push rod 32 being connected to a first elastic element 22. Each second receiving channel 103 is provided with a push rod 32 and a first elastic element 22. The push rod 32 is movable within the second receiving channel 103 along the axial direction of the conduit 10, so that by pushing the push rod 32, the first elastic element 22 is moved between the first receiving channel 1021 and the second receiving channel 103.

[0083] See Figure 6 and Figure 8 As shown, during the process of catheter 10 intervening in blood vessel 300, support device 20 is in the first state, that is, the first elastic element 22 and push rod 32 are both located in the second receiving channel 103, so as to facilitate support device 20 to smoothly reach blood vessel 300 through blood vessel 200.

[0084] See Figure 7 , Figure 9 and Figure 15 As shown, when the cantilever 102 enters the blood vessel 300, it pushes the push rod 32 to move distally, putting the support device 20 into a second state, i.e., the first elastic element 22 moves into the first receiving channel 1021. The first elastic element 22 causes the distal end of the cantilever 102 to bend radially outward along the catheter 10. The radial extension of the first elastic element 22 in the second state is greater than that in the first state, thereby causing multiple cantilever 102s at the distal end of the catheter 10 to open, fixing the distal end of the catheter 10 within the blood vessel 300. Since each push rod individually controls one first elastic element 22, the operator can adapt to the complex internal environment by pushing only some of the push rods to unfold part of the first elastic element 22, providing high flexibility.

[0085] It should be noted that, in this embodiment, in the second state, the gap between any two adjacent first elastic members 22 forms a fluid channel 201, allowing the chemical ablation substance injected into the blood vessel 300 from the catheter orifice 101 to diffuse towards the proximal side, effectively ablating target tissues such as plaques on the inner wall of the blood vessel near the inlet of the blood vessel 300. In this embodiment, in the first state, there is no gap between any two adjacent first elastic members 22, and the fluid channel 201 cannot be formed. However, in other embodiments, in the first state, there is also a gap between any two adjacent first elastic members 22, thus forming the fluid channel 201.

[0086] In this embodiment, multiple cantilever arms 102 expand to contact the inner wall of the blood vessel 300, reducing the area of ​​the support device 20 blocking the inner wall of the blood vessel 300, allowing the chemical ablation material to make more sufficient contact with the plaque on the inner wall of the blood vessel 300, and improving the ablation rate.

[0087] In this embodiment, the cantilever 102 is elastic, and the material of the cantilever 102 includes elastic materials such as polyurethane, polyether block amide, and / or silicone rubber.

[0088] Example 4

[0089] The differences between Embodiment 4 and Embodiment 1 will be described below. The similarities or similarities between Embodiment 4 and Embodiment 1 will not be repeated here.

[0090] In this embodiment, such as Figure 10 , Figure 11 and Figure 12 As shown, the support device 20 includes: a first support ring 23, a second support ring 24, and a plurality of second elastic elements 25.

[0091] Specifically, the first support ring 23 and the second support ring 24 are respectively sleeved on the outside of the injection section 12. The first support ring 23 and the second support ring 24 are spaced apart along the axial direction of the conduit 10. The second elastic element 25 is disposed between the first support ring 23 and the second support ring 24, and the two ends of the second elastic element 25 are respectively connected to the first support ring 23 and the second support ring 24. A plurality of second elastic elements 25 are arranged sequentially at intervals along the circumference of the conduit 10.

[0092] The mating component 30 is configured as an outer sheath 31, which is sleeved on the support device 20 and the conduit 10. The outer sheath 31 is movable relative to the conduit 10 and the support device 20 along the axial direction of the conduit 10.

[0093] At least one of the first support ring 23 and the second support ring 24 is movable relative to the injection section 12 along the axial direction of the conduit 10. The second elastic member 25 is rod-shaped and is in a bent rod shape when not subjected to external force.

[0094] See Figure 11 As shown, during the process of catheter 10 intervening in blood vessel 300, support device 20 is in the first state. At this time, outer sheath 31 is sleeved on catheter 10 and support device 20. Under the restraint of outer sheath 31, second elastic element 25 is in a straight rod shape, or second elastic element 25 is in a curved rod shape with a small degree of curvature, so as to facilitate support device 20 to smoothly pass through blood vessel 200 and reach blood vessel 300 under the wrapping of outer sheath 31.

[0095] See Figure 10 and Figure 12As shown, after the cantilever 102 enters the blood vessel 300, it pulls the outer sheath 31 proximally, causing the support device 20 to disengage from the outer sheath 31 and enter a second state. The radial extension of the second elastic element 25 in the first state is less than that in the second state. Specifically, the second elastic element 25 automatically bends under the action of elastic force, making the bending degree of the second elastic element 25 in the second state greater than that in the first state, causing the second elastic element 25 to arch outward along the radial direction of the catheter 10, thus fixing the distal end of the catheter 10 within the blood vessel 300.

[0096] like Figure 12 As shown, in the second state, the gap between any two adjacent second elastic members 25 forms a fluid channel 201, and the chemical ablation substance injected into the blood vessel 300 from the catheter port 101 can diffuse to the proximal side, fully ablate the target tissue such as plaques on the inner wall of the blood vessel near the entrance of the blood vessel 300.

[0097] In this embodiment, multiple second elastic members 25 abut against the inner wall of the blood vessel 300 in a centrally arched manner, reducing the area of ​​the support device 20 blocking the inner wall of the blood vessel 300, allowing the chemical ablation substance to make more sufficient contact with the plaque on the inner wall of the blood vessel 300, and improving the ablation rate.

[0098] It should be noted that after the support device 20 is detached from the outer sheath 31, in order to ensure that the second elastic element 25 can bend and deform under its own elastic force, at least one of the first support ring 23 and the second support ring 24 can move relative to the conduit 10 along the axial direction of the conduit 10 so that the first support ring 23 and the second support ring 24 can approach each other.

[0099] For example, if the first support ring 23 is fixedly connected to the injection section 12, then the second support ring 24 can be slidably sleeved on the outside of the injection section 12.

[0100] If the first support ring 23 and the second support ring 24 are slidably sleeved outside the injection section 12, then the injection section 12 needs to be provided with a limiting structure that abuts against the far end of the support device 20 to prevent the support device 20 from coming off from the far end of the injection section 12.

[0101] Example 5

[0102] The differences between Embodiment 5 and Embodiments 1, 2, 3 and 4 will be described below. The similarities or similarities between Embodiment 5 and Embodiments 1, 2, 3 and 4 will not be repeated here.

[0103] In this embodiment, such as Figure 4As shown, the outer peripheral surface of the injection section 121 is provided with a plurality of injection holes 1211, so that the chemical ablation material is injected into the blood vessel 300 from the catheter port 101 and the injection holes 1211 respectively, so that the flow rate of the injection section 121 is uniform at each position, which is conducive to more uniform diffusion of the chemical ablation material.

[0104] To facilitate better diffusion of the chemical ablation material into the proximal region of the injection segment 12, multiple injection holes 1211 are sequentially spaced along the axial direction of the catheter 10, forming multiple groups of injection holes 1211. Each group has multiple injection holes 1211, and the injection holes 1211 in each group are sequentially spaced along the circumference of the catheter 10. Specifically, from distal to proximal, the number of injection holes 1211 in each group increases sequentially, while the inner diameter of the injection holes 1211 decreases sequentially. Since the proximal region of the injection segment 12 is located relatively far from the catheter orifice 101, and the area to be ablated between this location and the vessel wall is narrower than other areas, the chemical ablation material is less likely to diffuse evenly in this region. To avoid affecting the flow rate at the catheter orifice 101, a larger number of injection holes 1211 with smaller inner diameters are arranged circumferentially in the proximal region of the injection segment 12, thereby improving the diffusion uniformity and flow rate at this location. In the distal region of the injection section 12, that is, near the catheter port 101, a small number of injection holes with a large inner diameter are provided to facilitate increasing the flow rate near the catheter port 101, and the cost of opening large holes is low.

[0105] In some embodiments, the plurality of injection holes 1211 are divided into three groups arranged at intervals along the axial direction of the conduit 10, with the first group, the second group, and the third group arranged sequentially from the distal end to the proximal end. The first group includes 2 injection holes 1211, the second group includes 4 injection holes 1211, and the third group includes 8 injection holes 1211. The inner diameter of the injection holes 1211 in the first group is larger than the inner diameter of the injection holes 1211 in the second group, and the inner diameter of the injection holes 1211 in the second group is larger than the inner diameter of the injection holes 1211 in the third group.

[0106] It should be emphasized that the technical solution of this embodiment can be combined with any one of the embodiments in Embodiment 1, Embodiment 2 and Embodiment 4, and the technical solution of this embodiment can be combined with any one of the embodiments in Embodiment 1, Embodiment 2 and Embodiment 4, which is also within the protection scope of this invention.

[0107] The above description is merely a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in the present invention should be included within the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be determined by the scope of the claims.

Claims

1. An ablation device, characterized in that, The ablation device includes a catheter, which comprises a main body section and an injection section. The injection section is connected to the distal end of the main body section, and the distal end of the injection section forms a catheter orifice. The maximum outer diameter of the injection segment is located on the proximal side, and the outer diameter of the proximal end of the injection segment is less than or equal to the outer diameter of the distal end of the main body segment, so that the proximal end of the injection segment or the area near the proximal end forms a fixed structure to fix the catheter, and also creates a gap between the injection segment and the inner wall of the blood vessel. The injection section includes an injection portion and a transition portion. The proximal end of the transition portion is connected to the distal end of the main body section, and the distal end of the transition portion is connected to the proximal end of the injection portion. The catheter orifice is formed at the distal end of the injection portion. The outer peripheral surface of the injection section is provided with multiple injection holes; The chemical ablation substance injected into the blood vessel through the catheter opening and the injection port can diffuse towards the proximal side of the blood vessel through the gap.

2. The ablation device according to claim 1, characterized in that, in, The fixing structure is disposed in the transition section, the maximum outer diameter of the transition section is less than or equal to the outer diameter of the main body section, and / or the minimum outer diameter of the transition section is greater than or equal to the outer diameter of the injection section.

3. The ablation device according to claim 2, characterized in that, The outer diameter of the transition portion gradually decreases from the proximal end to the distal end; and / or The outer peripheral surface of the transition section is recessed into the interior of the transition section along the radial direction of the conduit.

4. The ablation device according to any one of claims 1 to 3, characterized in that, The ablation device also includes: A support device is provided in the injection section, and at least a portion of the support device is movable relative to the injection section so that the support device can switch between a first state and a second state. In the first state, the maximum outer diameter of the support device is smaller than that in the second state. In the first state, the maximum outer diameter of the support device is less than or equal to the outer diameter of the main body segment. The support device has at least one fluid channel in the second state, and the fluid channel extends through the proximal and distal ends of the support device.

5. The ablation device according to claim 4, characterized in that, The support device includes at least one elastic element, and the ablation device further includes a mating element, which is disposed on the catheter in a manner that allows it to move axially along the catheter. The mating element cooperates with the elastic element to control the deformation of the elastic element.

6. The ablation device according to claim 5, characterized in that, The support device includes a self-expanding mesh, which is sleeved outside the injection section and connected to the outer peripheral surface of the injection section. The mesh openings of the mesh form the fluid channel. The fitting component is an outer sheath, which is sleeved over the support device and the conduit.

7. The ablation device according to claim 5, characterized in that, The distal end of the conduit is provided with multiple cantilever arms, which are arranged sequentially at intervals along the circumferential direction of the conduit. The interior of each cantilever arm is hollow to form a first receiving channel. The catheter is provided with a second receiving channel for each of the first receiving channels, and the distal end of the second receiving channel is connected to the first receiving channel; The support device includes a plurality of first elastic elements, and each second receiving channel is provided with a first elastic element. The first elastic element is movable between the second receiving channel and the first receiving channel. In the first state, the first elastic element is located in the second receiving channel. In the second state, the first elastic element is located in the first receiving channel. The radial extension of the first elastic element in the first state is less than the radial extension of the first elastic element in the second state. In the second state, the gap between any two adjacent first elastic elements forms the fluid channel. The distal end of the mating member is connected to the proximal end of the first elastic member, and is used to push the first elastic member to move from the second receiving channel to the first receiving channel to generate the second state.

8. The ablation device according to claim 5, characterized in that, The support device includes: The first support ring is sleeved outside the injection section; The second support ring is sleeved outside the injection section and spaced apart from the first support ring along the axial direction of the conduit; A plurality of second elastic elements are arranged sequentially at intervals along the circumference of the conduit, and the two ends of the second elastic elements are respectively connected to the first support ring and the second support ring; In this embodiment, at least one of the first support ring and the second support ring is movable relative to the injection section along the axial direction of the conduit. The radial extension of the second elastic element in the first state is less than that in the second state. In the second state, the first support ring and the second support ring are close to each other, and the gap between any two adjacent second elastic elements forms the fluid channel. The fitting is configured as an outer sheath, which is sleeved over the support device and the catheter.

9. The ablation device according to claim 1, characterized in that, Multiple injection holes are sequentially spaced along the axial direction of the conduit to form multiple sets of injection holes, each set having at least one injection hole; In this group, from the distal end to the proximal end, the number of injection holes increases sequentially and the inner diameter of the injection holes decreases sequentially.

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