An adjustable spinal cord impact vibration injury device and its injury method

Abstract

The present invention discloses an adjustable spinal cord impact vibration injury device and an injury method thereof, which belongs to the technical field of experimental research on spinal cord injury, and comprises a base; two lifting slide bars are fixedly installed on the rear end of the base, and a lifting slider that can slide vertically is installed on the lifting slide bar; an angle adjustment mechanism is installed on the lifting slider, and the movable end of the angle adjustment mechanism is detachably connected to a brace for fixing the experimental animal, and the angle adjustment mechanism is used to adjust the angle of the brace so that different parts of the experimental animal face the base; an impact trigger mechanism is also provided on the base. Through the above method, the experimental animal spinal cord impact concussion injury model prepared by adopting this technical solution can well simulate the injury process and post-injury pathophysiological changes of clinical spinal cord injury patients, and by changing the free fall height of the experimental animal, the upright impact rods of different materials and the impact point of the experimental animal, spinal cord impact concussion injury models with different injury modes and different injury degrees can be prepared.

Description

Technical Field

[0001] The present invention relates to the technical field of experimental research on spinal cord injury, and in particular to an adjustable spinal cord impact vibration injury device and an injury causing method thereof. Background Art

[0002] Currently, most spinal cord injuries are caused by natural disasters such as falls from heights, car accidents, and earthquakes. The mechanism of injury is that the impact of a free fall to the ground is transmitted through the muscles and spine, causing concussive damage to the spinal cord tissue. Concussive spinal cord injury is associated with more severe rupture of nerve roots and white matter fibers, demyelination, and damage to microvessels.

[0003] In existing medical experimental research, the NYU impactor and the IH impactor are the most commonly used biomechanical injury devices for preparing spinal cord contusion models. However, both devices place the experimental animals in a prone position, surgically incise the skin and separate the muscles to expose the spinal canal or spinal cord tissue, and then set different impact intensities and spinal cord tissue compression degrees to establish spinal cord injury models with different degrees of injury. These spinal cord injury models are mainly characterized by tissue bleeding and neuronal cell degeneration and necrosis. Although they can simulate the pathological and physiological reactions after spinal cord contusion to a certain extent, they are quite different from the injury mechanism and pathological changes of spinal cord injury patients admitted to the clinic, who are mainly suffering from spinal cord concussion injury. They cannot well simulate the pathological changes of clinical spinal cord concussion injury, which is mainly caused by damage to white matter fibers, making it difficult to find more effective treatment targets and provide more appropriate treatment strategies.

[0004] Based on this, the present invention designs an adjustable spinal cord impact vibration injury device and an injury method thereof to solve the above problems. Summary of the Invention

[0005] In view of the above-mentioned shortcomings of the prior art, the present invention provides an adjustable spinal cord impact vibration injury device and an injury causing method thereof.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solutions:

[0007] An adjustable spinal cord impact vibration injury device includes a base;

[0008] Two lifting slide bars are fixedly mounted on the rear end of the base, and a lifting slider that can slide vertically is mounted on the lifting slide bars;

[0009] An angle adjustment mechanism is installed on the lifting slider, and the movable end of the angle adjustment mechanism is detachably connected to a brace for fixing the experimental animal. The angle adjustment mechanism is used to adjust the angle of the brace so that different parts of the experimental animal face the base;

[0010] The base is also provided with an impact trigger mechanism for colliding with the experimental animal in the brace to cause impact and vibration damage to the animal's spinal cord tissue.

[0011] Furthermore, the impact trigger mechanism includes a rotating disk, a mounting tube and an upright impact rod. The rotating disk is rotatably mounted on the base. A plurality of mounting tubes are fixedly mounted on the upper end of the rotating disk along the circumference of the rotating disk. The mounting tubes are plugged into the upright impact rod.

[0012] Furthermore, the brace is made of thermoplastic material and is used to fit closely to the body surface of the experimental animal.

[0013] Furthermore, the upright impact rod is made of steel, plastic or foam, and the diameter of the top end of the upright impact rod is five millimeters or two millimeters.

[0014] Furthermore, the support includes a base plate, a placement tube, a pressure cover and a first knob. The base plate is fixedly installed at the lower end of the placement tube, the pressure cover is slidably connected to the inner side of the placement tube, the first knob is threadedly connected to the pressure cover through a screw, and a sliding groove is opened on one side of the placement tube along the length direction of the placement tube, and the screw of the first knob slides in the sliding groove.

[0015] Furthermore, the bottom plate is provided with a lower slot for exposing the buttocks of the experimental animal, and the side wall of the placement tube is provided with a side slot for exposing the back of the experimental animal.

[0016] Furthermore, the angle adjustment mechanism includes a fixed cylinder, a rotating rod, a fixed tooth block, a movable tooth block and a spring, one end of the fixed cylinder is fixedly connected to the lifting slider, and the other end of the fixed cylinder is fixedly installed with a fixed tooth block; the inner wall of the fixed cylinder is fitted and slidably connected to the side wall of the movable tooth block, and the movable tooth block and the fixed tooth block are clamped; one end of the rotating rod passes through the inner side of the fixed tooth block and is fixedly connected to the movable tooth block, and the other end of the rotating rod is fixedly connected to the connecting block; the spring is arranged in the fixed cylinder, and the two ends of the spring are respectively abutted against the fixed cylinder and the movable tooth block; the connecting block is detachably connected to the placement cylinder.

[0017] Furthermore, a pointer is provided on the connecting block, and a dial matching the pointer is fixedly mounted on one end of the fixing cylinder away from the lifting slider.

[0018] Furthermore, the base is also provided with an automatic lifting assembly for automatically lifting the lifting slider, the automatic lifting assembly including a linear module, a servo and a swing support block, the moving end of the linear module is fixedly mounted with the servo, and the output end of the servo is fixedly mounted with the swing support block;

[0019] In order to better achieve the purpose of the present invention, the present invention also provides an injury method of an adjustable spinal cord impact vibration injury device, comprising the following steps:

[0020] Step 1: After fixing the experimental animal with the brace, install the brace on the connecting block;

[0021] Step 2: The experimental animals are subjected to free fall from different heights perpendicular to the upper end surface of the base, so that the experimental animals collide only with the upright impact rod (73) to simulate the impact vibration injury of the spinal cord caused by different falling accelerations, thereby preparing spinal cord injury models caused by different falling heights; wherein the spinal cord injury models after falling include mild injury models, moderate injury models and severe injury models; when the lower limbs are immediately paralyzed and unable to walk and bear weight after falling, the model is successful; the lower limb motor function score of normal animals is 21 points, and the lower limb function score of 12 points or more 24 hours after injury is mild injury, 6-12 points is moderate injury, and less than 6 points is severe injury;

[0022] Step 3: The experimental animal is subjected to free fall from the same height perpendicular to the upper end surface of the base. By changing the material of the upright impact rod, the intensity of the impact and vibration injury to the spinal cord in different falling environments is simulated, thereby preparing spinal cord injury models of different injury degrees; the injury models include mild injury models, moderate injury models, and severe injury models; among them, the severe injury model is prepared using a steel impact rod, the moderate injury model is prepared using a plastic impact rod, and the mild injury model is prepared using a foam impact rod;

[0023] Step 4: Place the experimental animal in free fall from the same height, and adjust the angle between the brace and the upper end surface of the base so that the experimental animal freely falls onto the platform in different body positions, simulating the impact and shock injury to the spinal cord caused by landing at different positions under the same injury parameters; 90 degrees simulates the impact and shock injury caused by landing on the coccyx, 45 degrees simulates the impact and shock injury caused by landing on the ischial spine, and 0 degrees simulates the impact and shock injury caused by landing on the back.

[0024] Compared with the existing technology, the present invention has the following beneficial effects: 1. The spinal cord impact concussion injury model of rats (mice) prepared by adopting the technical solution can well simulate the injury process and post-injury pathophysiological changes of clinical spinal cord injury patients, and by changing the free fall height of rats (mice), upright impact rods of different materials, and impact points of rats (mice), spinal cord impact concussion injury models with different injury modes and different injury degrees can be prepared. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] To more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive effort.

[0026] Figure 1A three-dimensional adjustable spinal cord impact vibration injury device of the present invention Figure 1 ;

[0027] Figure 2 It is a front view of an adjustable spinal cord impact vibration injury device of the present invention;

[0028] Figure 3 This is a left side view of an adjustable spinal cord impact vibration injury device of the present invention;

[0029] Figure 4 A three-dimensional adjustable spinal cord impact vibration injury device of the present invention Figure 2 ;

[0030] Figure 5 is a perspective view of the brace of the present invention;

[0031] Figure 6 It is a three-dimensional diagram of the angle adjustment mechanism of the present invention.

[0032] Figure 7 It is a structural schematic diagram of the automatic lifting component of the present invention.

[0033] The numbers in the figure represent:

[0034] 1. Base; 2. Lifting slide bar; 3. Lifting slider; 4. Angle adjustment mechanism; 41. Fixed cylinder; 42. Rotating rod; 43. Fixed gear block; 44. Movable gear block; 45. Spring; 46. Scale plate; 47. Pointer; 5. Quick release assembly; 51. Bump; 52. Second knob; 6. Bracket; 61. Bottom plate; 62. Placement cylinder; 63. Slide groove; 64. Pressure cover; 65. First knob; 7. Impact trigger mechanism; 71. Rotating disk; 72. Mounting cylinder; 73. Upright impact rod; 8. Connecting block; 9. Automatic lifting assembly; 91. Linear module; 92. Servo; 93. Swing support block. DETAILED DESCRIPTION

[0035] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts shall fall within the scope of protection of the present invention.

[0036] The terms “left,” “right,” “front,” “back,” “up,” and “down” mentioned in the following description are oriented in the viewing direction of the front view.

[0037] Example 1: In some embodiments, please refer to the accompanying drawings of the specification. Figures 1-6, an adjustable spinal cord impact vibration injury device, comprising a base 1;

[0038] Two lifting slide bars 2 are fixedly mounted on the rear end of the base 1 , and a vertically slidable lifting slider 3 is mounted on the lifting slide bars 2 ; a scale for marking the height of the lifting slider 3 is provided on the lifting slide bars 2 .

[0039] An angle adjustment mechanism 4 is installed on the lifting slider 3. The movable end of the angle adjustment mechanism 4 is detachably connected to a support 6 for fixing the experimental rat (mouse). The angle adjustment mechanism 4 is used to adjust the angle of the support 6 so that different parts of the rat (mouse) face the base 1.

[0040] The base 1 is also provided with an impact trigger mechanism 7 for colliding with the rat (small rat) in the support 6 to cause impact and vibration damage to the animal's spinal cord tissue.

[0041] In the present invention, the lifting slider 3 can be moved vertically along the lifting slide rod 2 to adjust the height of the lifting slider 3. After the experimental rat is fixed by the support 6, the lifting slider 3 is slid to the set height and then released. The rat (rat) performs free fall motion, and the rat (rat) collides with the impact trigger mechanism 7 on the base 1, causing impact and vibration damage to the animal's spinal cord tissue. By adjusting the height of the lifting slider 3, different descent speeds of the rat (rat) can be obtained, and the support 6 can be rotated through the angle adjustment mechanism 4, so that the point of action of the impact injury can be located at different segments of the spinal cord, simulating the injury of the spinal cord caused by non-vertical fall.

[0042] See also Figure 1-Figure 3 The impact trigger mechanism 7 includes a rotating disk 71, a mounting tube 72 and an upright impact rod 73. The rotating disk 71 is rotatably mounted on the base 1. A plurality of mounting tubes 72 are fixedly mounted on the upper end of the rotating disk 71 along the circumference of the rotating disk 71. The mounting tubes 72 are plugged into the upright impact rod 73. The upright impact rod 73 can be made of a variety of materials such as steel, plastic and foam. Therefore, when conducting an injury experiment, by rotating the rotating disk 71 to align impact rods of different materials with large (small) mice, different degrees of impact spinal cord injury models can be obtained.

[0043] The thickness of the top of the upright impact rod 73 can be selected according to the different spinal cord injury models prepared for rats (small mice). Rats choose an impact rod with a diameter of 5 mm, and rats (small mice) choose an impact rod with a head diameter of 2 mm.

[0044] See also Figure 4 and Figure 5The support 6 includes a bottom plate 61, a placement tube 62, a pressure cover 64 and a first knob 65. The bottom plate 61 is fixedly mounted on the lower end of the placement tube 62, the pressure cover 64 is slidably connected to the inner side of the placement tube 62, and the first knob 65 is threadedly connected to the pressure cover 64 through a screw. A sliding groove 63 is provided on one side of the placement tube 62 along the length direction of the placement tube 62, and the screw of the first knob 65 slides in the sliding groove 63. When using the support 6, place the rat head toward the placement tube 62. The outer side is inserted into the placement tube 62, and the tail of the rat (small mouse) passes through the slide groove 63, and then the pressure cover 64 is inserted into the placement tube 62 until the bottom plate 61, the placement tube 62 and the pressure cover 64 cooperate to fix the rat (small mouse), and then the first knob 65 is tightened so that the first knob 65 is against the side wall of the placement tube 62 to fix the pressure cover 64, so that the rat (small mouse) is fit and fixed to prevent damage to important organs such as the heart, lungs, and brain due to body vibration during the injury process.

[0045] The bottom plate 61 is provided with a lower slot for exposing the buttocks of the rat (small rat), and the side wall of the placement tube 62 is provided with a side slot for exposing the back of the rat (small rat);

[0046] See also Figure 4 and Figure 6 The angle adjustment mechanism 4 includes a fixed cylinder 41, a rotating rod 42, a fixed tooth block 43, a movable tooth block 44 and a spring 45. One end of the fixed cylinder 41 is fixedly connected to the lifting slider 3, and the other end of the fixed cylinder 41 is fixedly installed with a fixed tooth block 43; the inner wall of the fixed cylinder 41 is fitted and slidably connected to the side wall of the movable tooth block 44, and the movable tooth block 44 is clamped with the fixed tooth block 43; one end of the rotating rod 42 passes through the inner side of the fixed tooth block 43 and is fixedly connected to the movable tooth block 44, and the other end of the rotating rod 42 is fixedly connected to the connecting block 8; the spring 45 is arranged in the fixed cylinder 41, and the two ends of the spring 45 are respectively abutted against the fixed cylinder 41 and the movable tooth block 44; the connecting block 8 is detachably connected to the placement cylinder 62;

[0047] The connecting block 8 is provided with a pointer 47 , and a scale plate 46 that matches the pointer 47 is fixedly mounted on one end of the fixing cylinder 41 away from the lifting slider 3 .

[0048] In the present invention, the connecting block 8 is pressed toward the fixed cylinder 41 to disengage the fixed tooth block 43 from the movable tooth block 44, and the fixed cylinder 41 can be rotated to adjust the angle of the fixed cylinder 41, so that the upright impact rod 73 passes through the lower slot or the side slot and aligns with different parts of the rat (small rat). This allows the point of impact injury to be located at different segments of the spinal cord, and can also simulate spinal cord impact vibration injuries caused by non-vertical falls.

[0049] Embodiment 2: In some embodiments, as Figure 4-Figure 6As shown, as a preferred embodiment of the present invention, the connecting block 8 and the fixed cylinder 41 are detachably connected through a quick-release assembly 5. The quick-release assembly 5 includes a protrusion 51 and a second knob 52. The protrusion 51 is fixedly installed on the side wall of the fixed cylinder 41. A groove for plugging into the protrusion 51 is provided on the connecting block 8. The second knob 52 is threadedly connected to the side of the connecting block 8 through a screw, and the end of the screw passes through the side wall of the connecting block 8 and abuts against the protrusion 51. By controlling the tightness of the second knob 52, the connecting block 8 and the brace 6 can be quickly installed and removed, which is convenient for replacing different experimental animals.

[0050] Embodiment 3: In some embodiments, as Figures 1-6 As shown in FIG. 1 , as a preferred embodiment of the present invention, a method for causing injury by an adjustable spinal cord impact vibration injury device comprises the following steps:

[0051] Step 1: Insert the rat (small rat) into the placement tube 62 with its head facing outward, and let the rat's tail pass through the slide 63. The rat (small rat) is fixed by the cooperation of the bottom plate 61, the placement tube 62 and the pressure cover 64, and the placement tube 62 is installed on the connecting block 8 through the quick release assembly 5.

[0052] Step 2: Make rats (mice) free fall from different heights perpendicular to the upper end surface of the base 1, so that the rats (mice) collide only with the upright impact rod 73 to simulate the impact vibration injury of the spinal cord caused by different falling accelerations, and then prepare spinal cord injury models caused by different falling heights; wherein the spinal cord injury model after falling includes a mild injury model, a moderate injury model and a severe injury model. The model is successful when the lower limbs are immediately paralyzed after falling, unable to walk and bear weight. The lower limb motor function score of normal animals is 21 points. 24 hours after the injury, the lower limb function score is 12 points or more, which is a mild injury, 6-12 points, which is a moderate injury, and less than 6 points, which is a severe injury.

[0053] Step 3: Rats (or mice) are subjected to free fall from the same height perpendicular to the upper surface of base 1. By varying the material of the upright impact rod 73, the intensity of spinal cord impact and vibration injuries caused by different falling environments is simulated, thereby creating spinal cord injury models of varying severity. These injury models include mild, moderate, and severe injury models. The severe injury model is created using a steel impact rod, the moderate injury model using a plastic impact rod, and the mild injury model using a foam impact rod.

[0054] Step 4: Place rats and mice in free fall from the same height. Use the angle adjustment mechanism 4 to adjust the angle between the brace 6 and the upper surface of the base 1, allowing the rats and mice to freely fall onto the platform in different body positions. This simulates the effects of impact and concussion injuries to the spinal cord caused by landing at different locations under the same injury parameters. A 90-degree angle simulates impact and concussion injuries caused by landing on the coccyx, a 45-degree angle simulates impact and concussion injuries caused by landing on the sciatic spine, and a 0-degree angle simulates impact and concussion injuries caused by landing on the back.

[0055] Embodiment 3: In some embodiments, as Figure 7 As shown, as a preferred embodiment of the present invention, the base 1 is also provided with an automatic lifting component 9 for automatically lifting the lifting slider 3. The automatic lifting component 9 includes a linear module 91, a servo 92 and a swing support block 93. The movable end of the linear module 91 is fixedly installed with the servo 92, and the output end of the servo 92 is fixedly installed with the swing support block 93; when the lifting slider 3 is at the lowest point, the linear module 91 controls the swing support block 93 to move vertically downward until the swing support block 93 is lower than the lowest point of the lifting slider 3, and then the swing support block 93 can be controlled to rotate by the servo 92. At this time, the linear module 91 can control the lifting slider 3 to servo move in the vertical direction through the swing support block 93, and after the lifting slider 3 moves to the set position, the servo 92 controls the swing support block 93 to reset to avoid the lifting slider 3, so that the lifting slider 3 performs free fall motion, thereby realizing automated and precise control of the free fall height of the lifting slider 3.

[0056] Example 4: In some embodiments, as a preferred embodiment of the present invention, the brace (6) can also be made of thermoplastic plastic material. After the material is heated and becomes plastic, it is wrapped around the rat (small mouse) and allowed to cool to form a contoured structure that fits closely with the body surface of the rat (small mouse) to prevent the chest and abdomen from colliding with the brace at the moment of falling and impact, thereby preventing damage to important organs (heart, liver, spleen, kidneys and other solid organs).

[0057] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the various embodiments of the present invention.

Claims

1. An adjustable spinal cord impact vibration injury device, comprising a base (1), characterized in that: Two lifting slide bars (2) are fixedly mounted on the rear end of the base (1), and scale marks are provided on the lifting slide bars (2). A lifting slider (3) capable of vertical sliding is mounted on the lifting slide bars (2); An angle adjustment mechanism (4) is installed on the lifting slider (3), and a movable end of the angle adjustment mechanism (4) is detachably connected to a support (6) for fixing the experimental animal, and the angle adjustment mechanism (4) is used to adjust the angle of the support (6) so that different parts of the experimental animal face the base (1); The base (1) is also provided with an impact trigger mechanism (7) for colliding with the experimental animal in the brace (6) to cause impact and vibration damage to the animal's spinal cord tissue; The impact trigger mechanism (7) comprises a rotating disk (71), a mounting cylinder (72) and an upright impact rod (73); the rotating disk (71) is rotatably mounted on the base (1); a plurality of mounting cylinders (72) are fixedly mounted on the upper end of the rotating disk (71) along the circumference of the rotating disk (71); the mounting cylinders (72) are plugged into the upright impact rod (73); The upright impact rod (73) is made of steel, plastic or foam, and the diameter of the top end of the upright impact rod (73) is five millimeters or two millimeters; The support (6) includes a base plate (61), a placement tube (62), a pressure cover (64) and a first knob (65), wherein the base plate (61) is fixedly mounted on the lower end of the placement tube (62), the pressure cover (64) is slidably connected to the inner side of the placement tube (62), and the first knob (65) is threadedly connected to the pressure cover (64) via a screw, and a slide groove (63) is provided on one side of the placement tube (62) along the length direction of the placement tube (62), and the screw of the first knob (65) slides in the slide groove (63); The angle adjustment mechanism (4) comprises a fixed cylinder (41), a rotating rod (42), a fixed tooth block (43), a movable tooth block (44) and a spring (45); one end of the fixed cylinder (41) is fixedly connected to the lifting slider (3), and the other end of the fixed cylinder (41) is fixedly mounted with the fixed tooth block (43); the inner wall of the fixed cylinder (41) is slidably connected to the side wall of the movable tooth block (44), and the movable tooth block (44) and the fixed tooth block (43) are engaged; one end of the rotating rod (42) passes through the inner side of the fixed tooth block (43) and is fixedly connected to the movable tooth block (44), and the other end of the rotating rod (42) is fixedly connected to the connecting block (8); the spring (45) is arranged in the fixed cylinder (41), and the two ends of the spring (45) are respectively in contact with the fixed cylinder (41) and the movable tooth block (44); the connecting block (8) is detachably connected to the placement cylinder (62).

2. The adjustable spinal cord impact vibration injury device according to claim 1, characterized in that: The brace (6) is made of thermoplastic material and is used to fit closely to the body surface of the experimental animal.

3. The adjustable spinal cord impact vibration injury device according to claim 1, characterized in that: The bottom plate (61) is provided with a lower slot for exposing the buttocks of the experimental animal, and the side wall of the placement cylinder (62) is provided with a side slot for exposing the back of the experimental animal.

4. The adjustable spinal cord impact vibration injury device according to claim 1, characterized in that: The connecting block (8) is provided with a pointer (47), and a dial (46) matching the pointer (47) is fixedly mounted on one end of the fixed cylinder (41) away from the lifting slider (3).

5. The adjustable spinal cord impact vibration injury device according to claim 1, characterized in that: The brace (6) is made of a self-shaping material that closely fits the body surface of the experimental animal, preventing the body of the experimental animal from shaking during the impact and vibration process.

6. A method of causing injury, using the adjustable spinal cord impact vibration injury device according to claim 1, characterized in that: The following steps are involved: Step 1: After the experimental animal is fixed with the brace (6), the brace (6) is mounted on the connecting block (8); Step 2: The experimental animals are subjected to free fall from different heights perpendicular to the upper end surface of the base (1), so that the experimental animals collide only with the upright impact rod (73) to simulate the impact vibration injury of the spinal cord caused by different falling accelerations, thereby preparing spinal cord injury models caused by different falling heights; wherein the spinal cord injury models after falling include mild injury models, moderate injury models and severe injury models; when the lower limbs are immediately paralyzed and unable to walk and bear weight after falling, the model is successfully established; the lower limb motor function score of normal animals is 21 points, and the lower limb function score of 12 points or more 24 hours after injury is mild injury, 6-12 points is moderate injury, and less than 6 points is severe injury; Step 3: The experimental animal is subjected to free fall motion perpendicular to the upper end surface of the base (1) from the same height, and the intensity of the impact vibration injury to the spinal cord caused by different falling environments is simulated by changing the material of the upright impact rod (73), thereby preparing spinal cord injury models with different injury degrees; the injury models include a mild injury model, a moderate injury model and a severe injury model; wherein the severe injury model is prepared using a steel impact rod, the moderate injury model is prepared using a plastic impact rod, and the mild injury model is prepared using a foam impact rod; Step 4: Make the experimental animals free fall from the same height, and adjust the angles of the brace (6) and the upper end surface of the base (1) so that the experimental animals fall freely on the platform in different body positions, simulating the impact of different parts of the body on the spinal cord under the same injury parameters; 90 degrees simulates the impact of the coccyx, 45 degrees simulates the impact of the ischial spine, and 0 degrees simulates the impact of the back.

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