Anti-shedding conditioning shampoo and method of making same

Abstract

The present application relates to a kind of anti-shedding repair shampoo and its preparation method, belong to the technical field of shampoo.A kind of anti-shedding repair shampoo includes the following components: surfactant, radix falcaliae polygoni multiflori complex, citric acid, preservative, chelating agent and deionized water.The shampoo formula prepared by the present application contains surfactant, radix falcaliae polygoni multiflori complex, citric acid, preservative and chelating agent and other ingredients, can nourish hair, regulate scalp environment, enhance hair strength and health, reduce hair breakage and shedding.Scalp cells absorb nutrients, maintain vitality, strengthen hair root stability, effectively prevent shedding and promote hair growth.

Description

TECHNICAL FIELD

[0001] The application belongs to the technical field of shampoo, and relates to a hair loss prevention and repair shampoo and a preparation method thereof. BACKGROUND

[0002] The application of the polygonum multiflorum extract in shampoo mainly reflects its various hair care effects, including nourishing blood and growing hair, darkening and brightening hair, removing dandruff and relieving itching, and nourishing the scalp. The polygonum multiflorum has the effects of tonifying liver and kidney and benefiting essence and blood. Through external use of the polygonum multiflorum shampoo, the effective components of the polygonum multiflorum can nourish the scalp and hair follicles, provide sufficient nutrients for the hair, and thus promote the growth of the hair. The various components in the polygonum multiflorum shampoo can regulate the oil balance of the scalp, reduce the generation of dandruff, and relieve the symptoms of itching of the scalp, so that the scalp remains fresh and comfortable. The active components in the polygonum multiflorum shampoo can deeply nourish the scalp and hair follicles, improve the scalp environment, promote the blood circulation of the scalp, and enhance the activity of the hair follicles, so as to enhance the growth of the hair and make the hair more dense and healthy.

[0003] Pullulan is a green and natural degradable polymer, which is a colorless and odorless white powder. The main chain of pullulan has a large number of hydroxyl groups, and has inherent biological activity. It is safe, non-toxic and edible, and has good film-forming property, fiber-forming property, low oxygen permeability, non-hygroscopicity, stability, adhesion and enzymatic degradation, and other functional properties. Therefore, it is often used as packaging materials, food additives, medical biomaterials and industrial coatings, and is widely used in the cosmetics, food and pharmaceutical industries. SUMMARY

[0004] The purpose of the present application is to provide a hair loss prevention and repair shampoo and a preparation method thereof. The shampoo prepared by the present application contains surfactants, polygonum multiflorum compound, citric acid, preservatives and chelating agents, and can nourish hair, regulate the scalp environment, enhance the toughness and health of the hair, and reduce hair breakage and shedding. The scalp cells absorb nutrients, maintain vitality, and strengthen the stability of the hair roots, effectively preventing hair loss and promoting hair growth.

[0005] The purpose of the present application can be achieved by the following technical solutions:

[0006] A hair loss prevention and repair shampoo comprises the following components by weight:

[0007] Surfactants 36-48 parts, polygonum multiflorum compound 10-13 parts, citric acid 0.2-0.4 parts, preservatives 1-2 parts, chelating agents 0.1-0.2 parts and deionized water 100-110 parts.

[0008] As a preferred technical solution of the present application, the surfactant is composed of cocamidopropyl betaine, sodium lauroylmethylamide, sodium lauroamphoacetate, sodium cocoylglycinate, sodium cocoylalaninate and propylene glycol laurate in a mass ratio of 10-12:3-4:5.5-6.0:1.2-1.5:1.3-1.8:6-7.

[0009] As a preferred technical solution of the present application, the preservative is composed of phenoxyethanol and sodium benzoate in a mass ratio of 1:1.2-1.5.

[0010] As a preferred technical solution of the present application, the chelating agent is EDTA-4Na.

[0011] As a preferred technical solution of the present application, the preparation of the polygonum multiflorum complex comprises the following steps:

[0012] 1) After stirring and mixing deionized water and pullulan, a complex monomer is added for ultrasonic mixing, and after cooling to room temperature, freeze-drying is performed to obtain a complex particle;

[0013] 2) After stirring and mixing the complex particle, an ethanol solution and a polygonum multiflorum extract, a crosslinking monomer is added for constant temperature stirring, and after cooling to room temperature, centrifugation, washing and freeze-drying, a polygonum multiflorum complex is obtained.

[0014] As a preferred technical solution of the present application, in step 1), the mass ratio of the deionized water, pullulan and complex monomer is 30-40:5.4-6.2:0.4-0.6; the complex monomer is composed of glutamic acid and phenylalanine in a mass ratio of 2.0-2.3:3.2-3.8; the stirring and mixing is performed at a stirring speed of 500-600 rpm for 20-30 min; and the ultrasonic mixing is performed at a power of 200-300 W for 30-40 min.

[0015] As a preferred technical solution of the present application, in step 2), the mass ratio of the complex particle, ethanol solution, polygonum multiflorum extract and crosslinking monomer is 13-15:40-50:2.5-3.0:1.2-1.4; the mass fraction of the ethanol solution is 60%; the stirring and mixing is performed at a stirring speed of 400-600 rpm for 30-40 min; and the constant temperature stirring is performed at a temperature of 60-68℃ for 6-8 h.

[0016] As a preferred technical solution of the present application, the preparation method of the crosslinking monomer comprises: mixing α-hexyl cinnamyl aldehyde, thiomalic acid, anhydrous ethanol and a photoinitiator, performing ultraviolet irradiation treatment, and removing the supernatant by centrifugation to obtain the crosslinking monomer.

[0017] As a preferred technical solution of the present application, the photoinitiator is photoinitiator 1173; the mass ratio of the n-hexyl phenyl propenal, thiomalic acid, anhydrous ethanol and photoinitiator is 6-7:5.0-5.5:50-60:0.21-0.23; the ultraviolet irradiation treatment is 365nm wavelength ultraviolet irradiation for 10-12h under the condition of stirring at a speed of 200-300rpm.

[0018] A preparation method of the anti-shedding and repairing shampoo comprises the following steps: mixing and stirring the polygonum multiflorum complex, the surfactant, the chelating agent and the deionized water, heating to 80-85 DEG C, keeping warm for 15-20min, adding the citric acid and the preservative, and stirring at 60-70 DEG C for 20-30min.

[0019] The present application has the following advantages:

[0020] The shampoo comprises the surfactant, the polygonum multiflorum complex, the citric acid, the preservative and the chelating agent. The product can nourish the hair and effectively regulate and improve the scalp environment, and can enhance the toughness and health of the hair. Therefore, the hair breakage and shedding caused by the weak hair can be reduced. The scalp cells can fully absorb the nutrients, so that the hair is full and vigorous, and the hair root is firmly fixed in the hair follicle, thereby achieving the effect of preventing hair loss and promoting hair growth.

[0021] The present application can form hydrogen bonds with the amino acid residues in the protein molecules by modifying the multiple natural components, which can change the oil and protein structure, so that the oil and protein are more easily decomposed and removed by the cleaning components, and the detergency of the shampoo is improved. DETAILED DESCRIPTION

[0022] In order to further illustrate the technical means and effects adopted by the present application to achieve the predetermined purposes, the specific embodiments, structures, features and effects according to the present application are described in detail as follows.

[0023] Example 1

[0024] The anti-shedding and repairing shampoo comprises the following components in parts by weight:

[0025] The surfactant is composed of cocamidopropyl betaine, sodium lauroylmethylamide, sodium lauroamphoacetate, sodium cocoylglycinate, sodium cocoylalaninate and propylene glycol laurate in a mass ratio of 10:3:5.5:1.2:1.3:6.

[0026] The surfactant is composed of cocamidopropyl betaine, sodium lauroylmethylamide, sodium lauroamphoacetate, sodium cocoylglycinate, sodium cocoylalaninate and propylene glycol laurate in a mass ratio of 10:3:5.5:1.2:1.3:6.

[0027] The preservative is composed of phenoxyethanol and sodium benzoate in a mass ratio of 1:1.2.

[0028] The chelating agent is EDTA-4Na.

[0029] A preparation method of the anti-shedding and repairing shampoo comprises the following steps: mixing and stirring the polygonum multiflorum complex, surfactant, chelating agent and deionized water, heating to 80℃, keeping for 15min, adding citric acid and preservative, stirring at 60℃ for 20min, and obtaining the product.

[0030] The preparation of the polygonum multiflorum complex comprises the following steps:

[0031] 1) mixing and stirring deionized water and pullulan, adding composite monomers for ultrasonic mixing, cooling to room temperature, and freeze-drying to obtain composite particles; wherein the mass ratio of the deionized water, pullulan and composite monomers is 30:5.4:0.4; the composite monomers are composed of glutamic acid and phenylalanine in a mass ratio of 2.0:3.2; the mixing and stirring is stirring at a speed of 500rpm for 20min; and the ultrasonic mixing is ultrasonic mixing at a power of 200W for 30min;

[0032] 2) mixing and stirring the composite particles, ethanol solution and polygonum multiflorum extract, adding crosslinking monomers for constant temperature stirring, cooling to room temperature, centrifuging, washing, and freeze-drying to obtain the polygonum multiflorum complex; wherein the mass ratio of the composite particles, ethanol solution, polygonum multiflorum extract and crosslinking monomers is 13:40:2.5:1.2; the mixing and stirring is stirring at a speed of 400rpm for 30min; and the constant temperature stirring is stirring at a temperature of 60℃ for 6h.

[0033] The preparation method of the crosslinking monomers comprises the following steps: mixing α-hexyl cinnamaldehyde, thiomalic acid, anhydrous ethanol and a photoinitiator, treating by ultraviolet irradiation, centrifuging to remove supernatant, and obtaining the crosslinking monomers; the photoinitiator is photoinitiator 1173; the mass ratio of the α-hexyl cinnamaldehyde, thiomalic acid, anhydrous ethanol and photoinitiator is 6:5.0:50:0.21; and the ultraviolet irradiation treatment is ultraviolet irradiation at a wavelength of 365nm for 10h under the condition of stirring at a speed of 200rpm.

[0034] Example 2

[0035] An anti-shedding and repairing shampoo comprises the following components by weight:

[0036] Surfactant 42 parts, polygonum multiflorum complex 11.5 parts, citric acid 0.3 parts, preservative 1.5 parts, chelating agent 0.15 parts and deionized water 105 parts.

[0037] The surfactant is composed of cocamidopropyl betaine, sodium lauroyl methyl amino acid, sodium lauroamphoacetate, sodium cocoyl glycinate, sodium cocoyl alaninate and propylene glycol laurate with a mass ratio of 11:3.5:5.8:1.4:1.6:6.5.

[0038] The preservative is composed of phenoxyethanol and sodium benzoate with a mass ratio of 1:1.4.

[0039] The chelating agent is EDTA-4Na.

[0040] A preparation method of the anti-hair loss and repair shampoo comprises the following steps: mixing and stirring the polygonum multiflorum complex, surfactant, chelating agent and deionized water, heating to 82℃, keeping for 18min, adding citric acid and preservative, stirring at 65℃ for 25min, and obtaining the product.

[0041] The preparation of the polygonum multiflorum complex comprises the following steps:

[0042] 1) mixing and stirring the deionized water and pullulan, adding the complex monomer for ultrasonic mixing, cooling to room temperature, and freeze-drying to obtain the complex particles; wherein the mass ratio of the deionized water, pullulan and complex monomer is 35:5.8:0.5; the complex monomer is composed of glutamic acid and phenylalanine with a mass ratio of 2.2:3.5; the mixing and stirring is stirring at 550rpm for 25min; and the ultrasonic mixing is ultrasonic mixing at 250W for 35min;

[0043] 2) mixing and stirring the complex particles, ethanol solution and polygonum multiflorum extract, adding the crosslinking monomer for constant temperature stirring, cooling to room temperature, centrifuging, washing, and freeze-drying to obtain the polygonum multiflorum complex; wherein the mass ratio of the complex particles, ethanol solution, polygonum multiflorum extract and crosslinking monomer is 14:45:2.8:1.3; the mixing and stirring is stirring at 500rpm for 35min; and the constant temperature stirring is stirring at 64℃ for 7h.

[0044] The preparation method of the crosslinking monomer comprises the following steps: mixing α-hexyl cinnamyl aldehyde, thiomalic acid, anhydrous ethanol and photoinitiator, treating by ultraviolet irradiation, centrifuging to remove the supernatant, and obtaining the crosslinking monomer; the photoinitiator is photoinitiator 1173; the mass ratio of the α-hexyl cinnamyl aldehyde, thiomalic acid, anhydrous ethanol and photoinitiator is 6.5:5.2:55:0.22; and the ultraviolet irradiation treatment is ultraviolet irradiation at 365nm wavelength for 11h under the condition of stirring at 250rpm.

[0045] Example 3

[0046] The anti-hair loss and repair shampoo comprises the following components by weight:

[0047] Surfactant 48 parts, polygonum multiflorum complex 13 parts, citric acid 0.4 parts, preservative 2 parts, chelating agent 0.2 parts and deionized water 110 parts.

[0048] The surfactant is composed of cocamidopropyl betaine, sodium lauroyl methyl amino acid, sodium lauroamphoacetate, sodium cocoyl glycinate, sodium cocoyl alaninate and propylene glycol laurate in a mass ratio of 12:4:6.0:1.5:1.8:7.

[0049] The preservative is composed of phenoxyethanol and sodium benzoate in a mass ratio of 1:1.5.

[0050] The chelating agent is EDTA-4Na.

[0051] A preparation method of the anti-falling hair care shampoo comprises the following steps: mixing and stirring the polygonum multiflorum complex, surfactant, chelating agent and deionized water uniformly, heating to 85℃, keeping for 20 min, adding citric acid and preservative, stirring at 70℃ for 30 min, and obtaining the product.

[0052] The preparation of the polygonum multiflorum complex comprises the following steps:

[0053] 1) After mixing and stirring the deionized water and pullulan, the composite monomer is added for ultrasonic mixing, and after cooling to room temperature, freeze-drying is performed to obtain the composite particles; wherein the mass ratio of the deionized water, pullulan and composite monomer is 40:6.2:0.6; the composite monomer is composed of glutamic acid and phenylalanine in a mass ratio of 2.3:3.8; the mixing and stirring is stirring at 600 rpm for 30 min; the ultrasonic mixing is ultrasonic mixing at 300 W for 40 min;

[0054] 2) After mixing and stirring the composite particles, ethanol solution and polygonum multiflorum extract, the crosslinking monomer is added for constant temperature stirring, and after cooling to room temperature, centrifugation, washing and freeze-drying, the polygonum multiflorum complex is obtained; wherein the mass ratio of the composite particles, ethanol solution, polygonum multiflorum extract and crosslinking monomer is 15:50:3.0:1.4; the mixing and stirring is stirring at 600 rpm for 40 min; the constant temperature stirring is stirring at 68℃ for 8 h.

[0055] The preparation method of the crosslinking monomer comprises the following steps: after mixing the α-hexyl cinnamyl aldehyde, thiomalic acid, anhydrous ethanol and photoinitiator, ultraviolet irradiation treatment is performed, the supernatant is removed by centrifugation to obtain the crosslinking monomer; the photoinitiator is photoinitiator 1173; the mass ratio of the α-hexyl cinnamyl aldehyde, thiomalic acid, anhydrous ethanol and photoinitiator is 7:5.5:60:0.23; the ultraviolet irradiation treatment is ultraviolet irradiation at 365 nm wavelength for 12 h under the condition of stirring at 300 rpm.

[0056] Comparative Example 1

[0057] Comparative Example 1 is different from Example 2 in that pullulan is not used, and the rest of the components, preparation steps and parameters are consistent.

[0058] Comparative Example 2

[0059] Comparative Example 2 is different from Example 2 in that the complex monomer of Comparative Example 2 is glutamic acid, and the rest of the components, preparation steps and parameters are consistent.

[0060] Comparative Example 3

[0061] Comparative Example 3 is different from Example 2 in that the complex monomer of Comparative Example 3 is phenylalanine, and the rest of the components, preparation steps and parameters are consistent.

[0062] Comparative Example 4

[0063] Comparative Example 4 is different from Example 2 in that no complex monomer is used in Comparative Example 4, and the rest of the components, preparation steps and parameters are consistent.

[0064] Comparative Example 5

[0065] Comparative Example 5 is different from Example 2 in that α-hexyl cinnamaldehyde is used instead of the crosslinking monomer in Comparative Example 5, and the rest of the components, preparation steps and parameters are consistent.

[0066] Comparative Example 6

[0067] Comparative Example 6 is different from Example 2 in that no crosslinking monomer is used in Comparative Example 6, and the rest of the components, preparation steps and parameters are consistent.

[0068] The shampoo samples prepared in Examples 1-3 and Comparative Examples 1-6 were respectively tested as follows.

[0069] Anti-hair loss effect test:

[0070] Before the shampoo test, the volunteers need to comb the hair 3 hours in advance to remove the hair that has already fallen off. After combing, the hair should be wrapped with a shower cap, and wait for shampooing in an environment with a temperature maintained at 25±3℃. During this period, avoid strenuous exercise. When shampooing, the water temperature should be controlled at 37±1℃. All waste water generated during shampooing should be collected in a water bucket. Before the end of shampooing, the hair is combed again to ensure that all the fallen hair is washed into the water bucket. Then, the fallen hair filtered from the water in the water bucket is counted and the number is recorded in detail, and the test results are shown in Table 1.

[0071] The increase rate of the number of fallen hair of each volunteer on the 40th day after using the corresponding shampoo sample and on the 1st day of use is calculated, and the calculation formula is as follows:

[0072] Hair loss number growth rate (%) = (40th day hair loss number - 1st day hair loss number) / 1st day hair loss number * 100%;

[0073] Table 1

[0074]

[0075]

[0076] From the test results in Table 1, it can be seen that the shampoo prepared in the present application has a significant anti-hair loss effect compared with Comparative Examples 1-6.

[0077] Grease removal test: 27 volunteers aged 25-40 years old were selected and divided into 9 groups, and their hair was cleaned using the shampoo samples (Examples 1-3, Comparative Examples 1-6). The volunteers' left forehead, right forehead, left occiput, and four scalp areas were tested for stratum corneum moisture content and oil content, and the initial data were recorded. On the 0th day, 14th day, and 28th day after providing the samples, the volunteers were asked to return after washing their hair the day before the test, and the change in scalp oil secretion after using the samples was recorded and observed using a skin oil test instrument, and the results are shown in Table 2.

[0078] Oil change rate (%) = (n-day oil secretion - 0-day oil secretion) / 0-day oil secretion * 100%;

[0079] Table 2

[0080]

[0081]

[0082] From the test results in Table 2, it can be seen that the shampoo prepared in the present application has a significant oil removal effect compared with Comparative Examples 1-6.

[0083] The present application forms a complex carrier by combining pullulan and amino acid monomers, which promotes the attachment of the polygonum multiflorum extract to the pullulan through the amino and carboxyl groups of the amino acid monomers. The pullulan can protect the polygonum multiflorum extract from external environmental factors (such as ultraviolet light, pollutants, etc.), form a protective film on the surface of the hair, reduce water evaporation from the hair, and at the same time, enhance the gloss and softness of the hair. In addition, pullulan is a natural polysaccharide with good biocompatibility and low irritation, which can reduce the stress of the polygonum multiflorum extract on the skin.

[0084] The present application introduces multiple carboxyl groups by forming a cross-linking monomer with alpha-hexyl cinnamaldehyde and thiomalic acid, which can increase the removal ability of oil, and the compound of glutamic acid and phenylalanine introduces a benzene ring structure while ensuring more carboxyl groups, which can further increase stability and decontamination ability, then the aldehyde group and the amino group of the amino acid monomer form a Schiff base compound with better stability, the Schiff base compound can form adsorption and coating on the extract of radix polygoni multiflori, control the release amount, reduce the skin irritation, the nitrogen atom in the Schiff base structure combines with the carboxyl group to form a hydrogen bond with the amino acid residues in the protein molecule, which may lead to changes in the structure of oil and protein, making it easier to be decomposed and removed by cleaning components, and improving the decontamination ability of the shampoo.

[0085] The above is only a preferred embodiment of the present application, not any form of limitation on the present application, although the present application has been disclosed as above with a preferred embodiment, however, it is not intended to limit the present application, any person skilled in the art, without departing from the scope of the technical scheme of the present application, can make some changes or modifications of the equivalent embodiments with the above disclosed technical content, but as long as it does not deviate from the technical scheme of the present application, any indirect modification, equivalent change and modification of the above embodiments according to the technical essence of the present application, still belongs to the scope of the technical scheme of the present application.

Claims

1. A hair loss prevention and repair shampoo, characterized in that, The following components are included by weight: The ingredients include 36-48 parts surfactant, 10-13 parts Polygonum multiflorum complex, 0.2-0.4 parts citric acid, 1-2 parts preservative, 0.1-0.2 parts chelating agent, and 100-110 parts deionized water. The preparation of the Polygonum multiflorum complex includes the following steps: 1) After stirring and mixing deionized water and pullulan, add the composite monomer and mix ultrasonically. After cooling to room temperature, freeze-dry to obtain composite particles; the composite monomer is composed of glutamic acid and phenylalanine in a mass ratio of 2.0-2.3:3.2-3.

8. 2) After mixing the composite particles, ethanol solution, and Polygonum multiflorum extract, the cross-linking monomer was added and stirred at a constant temperature. The mixture was then cooled to room temperature, centrifuged, washed, and freeze-dried to obtain the Polygonum multiflorum complex. The preparation method of the crosslinking monomer includes: mixing n-hexylphenyl acrolein, thiomalic acid, anhydrous ethanol and a photoinitiator, treating with ultraviolet light, centrifuging to remove the supernatant, and obtaining the crosslinking monomer.

2. The anti-hair loss repair shampoo according to claim 1, characterized in that: The surfactant is composed of cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium lauroamphoacetate, sodium cocoyl glycinate, sodium cocoyl alanine, and propylene glycol laurate in a mass ratio of 10-12:3-4:5.5-6.0:1.2-1.5:1.3-1.8:6-7.

3. The anti-hair loss repair shampoo according to claim 1, characterized in that: The preservative is composed of phenoxyethanol and sodium benzoate in a mass ratio of 1:1.2-1.5; the chelating agent is EDTA-4Na.

4. The anti-hair loss and repair shampoo according to claim 1, characterized in that: In step 1), the mass ratio of deionized water, pullulan polysaccharide, and complex monomer is 30-40: 5.4-6.2: 0.4-0.

6.

5. The anti-hair loss repair shampoo according to claim 1, characterized in that: In step 1), the stirring and mixing is performed at a speed of 500-600 rpm for 20-30 minutes; the ultrasonic mixing is performed at a power of 200-300W for 30-40 minutes.

6. The anti-hair loss repair shampoo according to claim 1, characterized in that: In step 2), the mass ratio of the composite particles, ethanol solution, Polygonum multiflorum extract and cross-linking monomer is 13-15:40-50:2.5-3.0:1.2-1.

4.

7. The anti-hair loss repair shampoo according to claim 1, characterized in that: In step 2), the stirring and mixing is carried out at a speed of 400-600 rpm for 30-40 minutes; the constant temperature stirring is carried out at a temperature of 60-68℃ for 6-8 hours.

8. The anti-hair loss repair shampoo according to claim 1, characterized in that: In the preparation of the crosslinking monomer, the photoinitiator is photoinitiator 1173; the mass ratio of n-hexylphenyl acrolein, thiomalic acid, anhydrous ethanol and photoinitiator is 6-7:5.0-5.5:50-60:0.21-0.23; the ultraviolet irradiation treatment is performed by stirring at 200-300 rpm and irradiating with ultraviolet light at a wavelength of 365 nm for 10-12 hours.

9. A method for preparing an anti-hair loss repair shampoo as described in any one of claims 1-8, characterized in that, The preparation method includes the following steps: after mixing and stirring the Polygonum multiflorum complex, surfactant, chelating agent and deionized water evenly, heat to 80-85℃ and keep warm for 15-20 minutes, add citric acid and preservative and stir at 60-70℃ for 20-30 minutes to obtain the final product.

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