Anti-aging and skin barrier repair compositions, products and applications thereof

Abstract

The present invention relates to the field of cosmetics, and in particular to anti-aging and skin barrier repair compositions, products and their applications. The present invention provides an anti-aging and skin barrier repair composition, comprising: lactobionic acid, cedar bud extract and condiment Murraya odorata stem extract. The present application uses a compound of lactobionic acid, cedar bud extract and condiment Murraya odorata stem extract to have a synergistic effect, which can significantly promote the increase in COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect. In addition, the composition provided in the present application can significantly increase the relative expression levels of FLG and LOR genes in a human immortalized keratinocyte model, and has the effect of repairing the skin barrier.

Description

Technical Field

[0001] The present invention relates to the field of cosmetics, and in particular to anti-aging and skin barrier repairing compositions, products and applications thereof. Background Art

[0002] Aging is a complex and continuous biological process characterized by cellular and molecular changes, a gradual decline in the body's ability to maintain homeostasis, and increased apoptosis and senescence, which become more pronounced with time.

[0003] Skin aging occurs through two primary processes: intrinsic and extrinsic. Intrinsic aging is controlled by a person's genetics and manifests itself gradually over time, an inevitable process. Extrinsic aging, on the other hand, is primarily caused by environmental factors, such as UV radiation, smoking, wind, sun exposure, and exposure to harmful chemicals. At the cellular level, skin aging also brings about functional changes, including decreased keratinocyte proliferation, reduced stratum corneum formation, decreased regeneration of the protective barrier, and reduced lipid synthesis.

[0004] The prior art has disclosed a variety of anti-aging products, such as retinol and retinol derivatives, which have strong anti-aging effects but are highly irritating. Peptides and collagen-based anti-aging substances are mild and effective, but they are expensive and the active ingredients are not stable. Summary of the Invention

[0005] In view of this, the present invention provides an anti-aging and skin barrier repair composition, product and application thereof. The composition provided by the present invention has a synergistic effect and can effectively resist aging and repair the skin barrier.

[0006] The invention provides an anti-aging and skin barrier repairing composition, comprising lactobionic acid, a cedar bud extract and a condiment, a Murraya oleifera stem extract.

[0007] Lactobionic acid is a polyhydroxy biomimetic acid with the molecular formula C 12 H 22 O 12, with the structural formula shown in formula (I), has broad application prospects in the food, pharmaceutical, and chemical industries. Lactobionic acid has multiple functions such as moisturizing, repairing, anti-aging, and anti-oxidation. For example, lactobionic acid contains eight hydrophilic hydroxyl groups, so it has good hygroscopicity and can bind water in the epidermis. As an effective moisturizer, it softens the skin surface and reduces the appearance of fine wrinkles. For example, lactobionic acid can chelate with metal ions, inhibit the activity of matrix metalloproteinases (MMPs), protect collagen, improve skin elasticity, and effectively reduce the effects of photoaging. Moreover, lactobionic acid has a significant effect on improving the homeostasis of the epidermal barrier and the function of the stratum corneum, but it does not cause side effects such as irritation and stinging similar to traditional hydroxy acids (such as glycolic acid), and can act on sensitive skin.

[0008] Formula (I).

[0009] Cryptomeria japonica bud extract, also known as CRYPTOMERIA JAPONICA BUD EXTRACT, is an extract extracted from the tender buds of Cryptomeria japonica and has the following effects:

[0010] (1) Promote the regeneration of skin tissue structure: Cryptomeria japonica bud extract can stimulate the regeneration of skin cells, enhance the vitality of skin tissue, and help reshape a healthy skin structure.

[0011] (2) Comprehensively strengthen the skin: Cryptomeria japonica bud extract has antioxidant and anti-free radical properties, which can effectively resist the effects of harmful factors in the environment on the skin, thereby comprehensively improving the skin's resistance.

[0012] (3) Create a moist and plump texture: Cryptomeria japonica bud extract contains rich natural moisturizing ingredients, which can effectively retain the skin's moisture, making the skin more hydrated, plump and elastic.

[0013] (4) Forming a barrier to protect the skin: Cryptomeria japonica bud extract can form a protective film on the surface of the skin, effectively blocking external stimuli and pollution, thereby protecting the skin from external damage.

[0014] (5) Anti-allergic: Cryptomeria japonica bud extract has excellent anti-inflammatory and anti-allergic effects, which can effectively relieve skin allergy symptoms, reduce allergic reactions, and make the skin healthier and more comfortable.

[0015] The present application does not particularly limit the source of the Cryptomeria japonica bud extract; commercially available products are sufficient. In some specific implementations, the Cryptomeria japonica bud extract is a commercially available product extracted with water and butylene glycol, and has an isopimaric acid content greater than 150 ppm, preferably greater than 170 ppm, more preferably greater than 190 ppm, and most preferably greater than 200 ppm.

[0016] Murraya Koenigii Stem Extract, also known as Murraya Koenigii Stem Extract, is an extract from the stem of Murraya exotica L., a plant of the Rutaceae family. Murraya Koenigii stem extract can promote skin cell metabolism, accelerating the shedding of old cells and the formation of new ones, restoring skin's radiance and elasticity.

[0017] The present application has no particular restrictions on the source of the Murraya odorata stem extract, and any commercially available product may be used. In some specific implementations, the Murraya odorata stem extract is a commercially available product extracted from water, propylene glycol, and betaine, and has a flavonoid content greater than 30 ppm, preferably greater than 35 ppm.

[0018] The inventors discovered that the combined use of lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya oleifera stem extract has a synergistic effect, which can significantly promote the increase in COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen and elastin, and has a more obvious anti-wrinkle effect.

[0019] In some embodiments of the present invention, the above composition comprises, by weight, 0.3 to 8 parts of lactobionic acid, 0.5 to 25 parts of Cryptomeria japonica bud extract, and 0.4 to 35 parts of Murraya odorifera stem extract.

[0020] In some embodiments of the present invention, the above composition comprises, by weight, 0.3-6 parts of lactobionic acid, 0.5-20 parts of Cryptomeria japonica bud extract, and 0.4-30 parts of Murraya odorifera stem extract.

[0021] In some embodiments of the present invention, the above composition comprises, by weight, 0.5-4 parts of lactobionic acid, 1-15 parts of Cryptomeria japonica bud extract, and 0.5-20 parts of Murraya odorifera stem extract.

[0022] In some embodiments of the present invention, the above composition comprises, by weight, 1 to 3 parts of lactobionic acid, 1.5 to 12 parts of Cryptomeria japonica bud extract, and 1 to 15 parts of Murraya odorifera stem extract.

[0023] In some embodiments of the present invention, the above composition, in parts by weight, comprises: 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract and 6 parts of Murraya odorifera stem extract;

[0024] In some embodiments of the present invention, the above composition, in parts by weight, comprises: 4 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract;

[0025] In some embodiments of the present invention, the above composition, in parts by weight, comprises: 0.3 parts of lactobionic acid, 0.5 parts of cedar bud extract and 0.4 parts of Murraya paniculata stem extract;

[0026] In some embodiments of the present invention, the above composition, in parts by weight, comprises: 1 part of lactobionic acid, 12 parts of Cryptomeria japonica bud extract and 15 parts of Murraya odorifera stem extract;

[0027] In some embodiments of the present invention, the above composition, in parts by weight, comprises: 6 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract;

[0028] In some embodiments of the present invention, the above composition comprises, by weight, 2 parts of lactobionic acid, 1.5 parts of Cryptomeria japonica bud extract and 1 part of Murraya odorifera stem extract.

[0029] The present invention also provides the use of the above-mentioned composition in the preparation of anti-aging products. Experimental results show that the combination of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract has a synergistic effect, significantly promoting the expression of COL1A1, COL3A1, and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen, and elastin, and demonstrating significant anti-wrinkle efficacy.

[0030] The present invention also provides the use of the above-mentioned composition in the preparation of a skin-repairing product. Experimental results show that the combination of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract can significantly increase the relative expression of FLG and LOR genes in a human immortalized keratinocyte model, demonstrating the ability to repair the skin barrier.

[0031] The present invention also provides a product, comprising: the anti-aging and skin barrier repairing composition described in the above technical solution.

[0032] In some embodiments of the present invention, the above-mentioned products include but are not limited to personal care products, medicines, etc. Those skilled in the art will understand that, in addition to the composition described in the above technical solution, other excipients may also be included, such as pharmaceutical excipients or excipients for personal care products.

[0033] In some embodiments of the present invention, the personal care product includes: a basic care product and / or a makeup product.

[0034] In some embodiments of the present invention, the cosmetic products include but are not limited to:

[0035] (1) Foundation makeup:

[0036] Liquid foundation / cream: used to even out skin tone and cover blemishes;

[0037] BB Cream / CC Cream: A lightweight makeup base that combines skincare and finishing touches.

[0038] Concealer / pen: for covering local areas such as acne, dark circles, etc.

[0039] Loose powder / face powder: sets makeup and reduces facial shine.

[0040] (2) Eye makeup:

[0041] Eyeshadow: adds color and depth to the eyes;

[0042] Eyeliner pencil / liquid / gel: outline the eyeliner to make the eyes look more vivid;

[0043] Mascara: lengthens and thickens eyelashes, adds depth to eyes;

[0044] Eyebrow pencil / eyebrow powder / eyebrow gel: fill in the gaps in the eyebrows and shape the ideal eyebrows.

[0045] (3) Cheek makeup:

[0046] Blush: Add natural redness to cheeks and enhance complexion;

[0047] Contouring cake / stick: Use shading techniques to make the facial contours more three-dimensional;

[0048] (4) Lip makeup:

[0049] Lipstick / Lip Glaze / Lip Gloss: Change or emphasize the color of the lips;

[0050] Lip liner: Draw a clear lip boundary to prevent lipstick from overflowing.

[0051] (5) Multifunctional cosmetics:

[0052] Highlighter stick / liquid / powder: Brighten the high points of the face (such as the bridge of the nose and cheekbones) to create a radiant effect.

[0053] In addition, there are products designed specifically for special occasions, such as waterproof and sweat-proof eyeliner and long-lasting lipstick.

[0054] In some embodiments of the present invention, the basic care products include but are not limited to:

[0055] Facial Cleanser / Face Wash: Gently removes dirt, oil and makeup residue from the face;

[0056] Makeup remover oil / makeup remover water / makeup remover cream: specially designed to completely remove makeup, especially waterproof makeup;

[0057] Toner / Lotion: Use after cleansing to further cleanse residue on the skin surface, replenish moisture to the skin, restore the skin's pH balance, and lay a good foundation for the absorption of subsequent skin care products;

[0058] Essence: Contains high concentrations of active ingredients, providing deep nourishment and repair for specific skin problems (such as anti-aging, moisturizing, whitening, etc.);

[0059] Eye cream: specially designed for the sensitive area around the eyes, it can reduce fine lines, dark circles and tighten the skin around the eyes. The texture is usually light and easy to absorb.

[0060] Day / night lotion or cream: has the functions of protecting, repairing and nourishing, promoting cell regeneration, etc., which can provide the skin with necessary moisture and lock in the replenished moisture;

[0061] Sunscreen: used for UV protection, prevention of photoaging, etc.;

[0062] Facial masks: Provide extra nourishment and care to the skin, such as hydration, pore cleansing or brightening.

[0063] This application adds lactobionic acid, Cryptomeria japonica bud extract and the seasoning Murraya odorifera stem extract to the above-mentioned product for use, which can have the effects of anti-aging and repairing the skin barrier. This application has no special restrictions on other active ingredients in the product, and they can be added as needed. This application also has no special restrictions on the excipients in the product, and they can be added according to the product type. This application has no special restrictions on the preparation method of the product, and the preparation method can be adjusted according to the specific substances selected in the product formula.

[0064] The combination of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract has been shown to have a synergistic effect, significantly increasing the expression of COL1A1, COL3A1, and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen, and elastin, demonstrating significant anti-wrinkle efficacy. Furthermore, the composition provided herein can significantly increase the relative expression of FLG and LOR genes in a human immortalized keratinocyte model, demonstrating its ability to repair the skin barrier. BRIEF DESCRIPTION OF THE DRAWINGS

[0065] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for describing the embodiments or the prior art.

[0066] Figure 1 The test results of the relative expression of FLG gene in Example 1 are as follows;

[0067] Figure 2This is the test result of the relative expression level of LOR gene in Example 1. DETAILED DESCRIPTION

[0068] The present invention relates to the field of cosmetics, in particular to anti-aging and skin barrier repairing compositions, products and applications thereof.

[0069] It should be understood that the expression "one or more of" includes individually each of the items recited after the expression and various combinations of two or more of the recited items, unless otherwise apparent from the context and usage. The expression "and / or" in conjunction with three or more recited items should be understood to have the same meaning, unless otherwise apparent from the context.

[0070] The terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, e.g., not excluding other unrecited elements or steps, unless otherwise specifically stated or understood from the context.

[0071] It should be understood that the order of steps or the order in which certain actions are performed are not important as long as the present invention remains operable. Additionally, two or more steps or actions may be performed simultaneously.

[0072] The use of any and all examples or exemplary language, such as "such as" or "including," herein is intended merely to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating any non-claimed element as essential to the practice of the invention.

[0073] In addition, the numerical ranges and parameters used to define the present invention are approximate values. The relevant numerical values in the specific examples have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual testing methods. Therefore, unless otherwise expressly stated, it should be understood that all ranges, amounts, values, and percentages used in this disclosure are modified by the word "about." As used herein, "about" generally means that the actual value is within plus or minus 10%, 5%, 1%, or 0.5% of a particular value or range.

[0074] The invention provides an anti-aging and skin barrier repairing composition, comprising lactobionic acid, a cedar bud extract and a condiment, a Murraya oleifera stem extract.

[0075] The combination of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract has been shown to have a synergistic effect, significantly promoting the expression of COL1A1, COL3A1, and ELN genes in human dermal fibroblasts after UVA radiation, thereby increasing the production of type I collagen, type III collagen, and elastin, with significant anti-wrinkle efficacy. Furthermore, the anti-aging and skin barrier repair composition provided in this application can significantly increase the relative expression of FLG and LOR genes in a human immortalized keratinocyte model, demonstrating its ability to repair the skin barrier.

[0076] The present invention will be further described below in conjunction with the embodiments:

[0077] In the following examples and comparative examples, the cedar bud extract and the condiment Murraya paniculata stem extract were purchased on the market. Among them, the cedar bud extract was obtained by extraction with water and butylene glycol, and its isopimaric acid content was about 200 ppm; the condiment Murraya paniculata stem extract was obtained by extraction with water, propylene glycol and betaine, and its flavonoid content was about 35 ppm.

[0078] Examples 1 to 7, Comparative Examples 1-1 to 7-2

[0079] According to the formula shown in Table 1, corresponding weights of lactobionic acid, Cryptomeria japonica bud extract and Murraya oleifera stem extract were mixed to obtain a composition.

[0080] Table 1 Composition formula provided in Examples and Comparative Examples

[0081]

[0082] Test Example 1

[0083] Human dermal fibroblast model, the increase in COL1A1, COL3A1 and ELN gene expression in human dermal fibroblasts after UVA irradiation is used to evaluate whether the sample has anti-wrinkle efficacy.

[0084] (1) Experimental system:

[0085] Cell line: human dermal fibroblasts;

[0086] Cell generation number: at least 2 generations;

[0087] The number of cells per group: 3×10 5 Pieces / hole.

[0088] (2) Experimental steps:

[0089] 1. Inoculate cells into 6-well plates (3×10 5 / well), incubated at 37°C, 5% CO2 for 24 h;

[0090] 2. After the incubation, remove the culture medium and wash with D-Hanks for 1-2 times. Then, expose the sample group and the model control group to UVA light at 5J / cm 2 ;

[0091] 3. After modeling, the normal control group and the model control group were replaced with fresh culture medium, and the sample group was added with fresh culture medium containing the above samples. The final concentrations of each sample are shown in Table 2. The cells were incubated at 37°C and 5% CO2 for 24 h.

[0092] Table 2 Final concentration of each sample

[0093]

[0094] 4. Extract total RNA from each experimental group, synthesize cDNA, and use q-PCR to detect the gene expression of β-actin and target genes;

[0095] 5. Using β-actin as the internal reference for gene expression, calculate the relative RNA expression of the target gene according to the following formula:

[0096] Relative RNA expression = 2 ΔΔC(t) ;

[0097] ;

[0098] ΔC(t)=C(t) 目的基因 -C(t) β-actin ;

[0099] ;

[0100] Where Q is the relative gene expression level.

[0101] The results are shown in Table 3, which shows the test results of the Examples and Comparative Examples of the present application on the expression increase rates of COL1A1, COL3A1 and ELN genes in human dermal fibroblasts after UVA radiation.

[0102] Table 3 Test results of gene expression enhancement rate

[0103]

[0104] In Table 3 , the up-regulation rate of the relative expression of each gene is the value not *100%;

[0105] In Table 3, the synergy coefficient is calculated according to the King method, and the calculation formula is as follows:

[0106] q=E A+B / (E A +EB -E A *E B )

[0107] Among them, q is the synergy coefficient, E A+B is the up-regulation rate of the corresponding gene in Example X, E A is the up-regulation rate of the corresponding gene in comparison example X-1, E B It is the up-regulation rate of the corresponding gene by comparative example X-2.

[0108] As shown in Table 3, lactobionic acid, Cryptomeria japonica bud extract and Murraya oleifera stem extract all have a synergistic effect in the ratio range of 0.3~6:0.5~20:0.4~30, which can significantly promote the increase of COL1A1, COL3A1 and ELN gene expressions in human dermal fibroblasts after UVA radiation.

[0109] UV radiation accelerates skin aging through a complex series of reactions. COL1A1 is the gene responsible for producing type I collagen, COL3A1 is the gene responsible for producing type III collagen, and ELN is the gene responsible for producing elastin. Therefore, a combination of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract significantly boosted the expression of COL1A1, COL3A1, and ELN genes in human dermal fibroblasts after UVA exposure, thereby increasing the production of type I and type III collagen, as well as elastin, demonstrating significant anti-wrinkle effects.

[0110] Test Example 2

[0111] According to the method disclosed in the "Cosmetic Barrier Repair Efficacy Test - In Vitro Human Immortalized Keratinocyte Barrier Repair Factor Determination Standard Operating Procedure", human immortalized keratinocytes were used as a model, and the sample prepared in Example 1 was applied to the cells to detect the relative expression levels of FLG and LOR genes to evaluate whether the sample had repair efficacy.

[0112] (1) Experimental system:

[0113] Cell line: human immortalized keratinocytes;

[0114] Cell generation number: at least 2 generations;

[0115] The number of cells per experimental group: 6×10 5 pcs / hole;

[0116] (2) Experimental steps:

[0117] 1. Inoculate cells into 6-well plates (6×10 5 / well), incubated at 37°C, 5% CO2 for 24 h;

[0118] 2. After the incubation, the cells were gently rinsed once or twice with D-Hanks. Fresh culture medium was added to the normal control group, and fresh culture medium containing the sample of Example 1 was added to the sample group. The total final concentration of lactobionic acid, Cryptomeria japonica bud extract, and Murraya oleifera stem extract in the sample of Example 1 was 0.3125%. The cells were incubated at 37°C, 5% CO2 for 24 h.

[0119] 3. After the culture is completed, the cells are sampled, total RNA of each experimental group is extracted, cDNA is synthesized, and the gene expression of β-actin and the target gene is detected by q-PCR;

[0120] 4. Using β-actin as the internal reference for gene expression, calculate the relative RNA expression of the target gene according to the following formula:

[0121] Relative RNA expression = 2 ΔΔC(t) ;

[0122] ;

[0123] ΔC(t)=C(t) 目的基因 -C(t) β-actin .

[0124] The results are shown in Table 4. Figure 1 and Figure 2 Table 4 shows the test results of the relative expression levels of FLG and LOR genes in Example 1. Figure 1 The test results of the relative expression of FLG gene in Example 1 are as follows: Figure 2 This is the test result of the relative expression level of LOR gene in Example 1.

[0125] Table 4 Test results of relative expression of FLG and LOR genes in Example 1

[0126]

[0127] In Table 4, * indicates that the p value is less than 0.05 when compared with the normal control group, and ** indicates that the p value is less than 0.01 when compared with the normal control group.

[0128] Regulating FLG gene expression is a key factor in the repair of skin barrier damage. Studies have shown that upregulating FLG gene expression can enhance skin barrier function, thereby repairing damaged skin. Loricrin (LOR) is a major component of the corneal stratum corneum, accounting for approximately 80% of the total corneal stratum corneum protein. It is primarily present in the stratum granulosum of the epidermis. Its primary function is to strengthen the corneal stratum corneum, enhance the permeability barrier, and interact with intermediate filaments to increase the flexibility of the corneal stratum corneum structure, playing a crucial role in the epidermal barrier function.

[0129] As can be seen from Table 4, the composition provided in the present application can significantly increase the relative expression levels of FLG and LOR genes, thereby having the effect of repairing the skin barrier.

[0130] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principles of the present invention. These improvements and modifications should also be regarded as within the scope of protection of the present invention.

Claims

1. An anti-aging and skin barrier repairing composition, characterized in that: The composition comprises, by weight, 0.3 to 8 parts of lactobionic acid, 0.5 to 25 parts of cedar bud extract and 0.4 to 35 parts of Murraya paniculata stem extract; The cryptomeria japonica bud extract is obtained by extracting water and butylene glycol; The content of isopimaric acid in the Cryptomeria japonica bud extract is greater than 150 ppm; The seasoning Murraya paniculata stem extract is obtained by extracting water, propylene glycol and betaine; The flavonoid content in the seasoning Murraya paniculata stem extract is greater than 30 ppm.

2. The anti-aging and skin barrier repairing composition according to claim 1, characterized in that: The invention comprises, by weight, 0.3-6 parts of lactobionic acid, 0.5-20 parts of cedar bud extract and 0.4-30 parts of Murraya odorifera stem extract.

3. The anti-aging and skin barrier repairing composition according to claim 2, characterized in that: Calculated by weight, it comprises: 6 parts of lactobionic acid, 6 parts of Cryptomeria japonica bud extract and 6 parts of Murraya oleifera stem extract; Or it includes: 4 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract; Or comprising: 0.3 parts of lactobionic acid, 0.5 parts of cedar bud extract and 0.4 parts of Murraya paniculata stem extract; Or comprising: 1 part of lactobionic acid, 12 parts of Cryptomeria japonica bud extract and 15 parts of Murraya odorifera stem extract; Or comprising: 6 parts of lactobionic acid, 20 parts of Cryptomeria japonica bud extract and 30 parts of Murraya odorifera stem extract; Alternatively, the composition comprises: 2 parts of lactobionic acid, 1.5 parts of Japanese cedar bud extract and 1 part of seasoning Murraya paniculata stem extract.

4. Use of the anti-aging and skin barrier repairing composition according to any one of claims 1 to 3 in the preparation of anti-aging products.

5. Use of the anti-aging and skin barrier repairing composition according to any one of claims 1 to 3 in the preparation of repair products.

6. Personal care product, characterized in that, include: The anti-aging and skin barrier repair composition according to any one of claims 1 to 3.

7. The personal care product according to claim 6, wherein: include: Basic skin care products and / or makeup products.

Images