Spray for conditioning rhinitis symptoms and rapidly relieving pain

Abstract

The invention discloses a spray for conditioning rhinitis symptoms and rapidly relieving pain. The invention belongs to the technical field of rhinitis conditioning, radix clematidis, rhizoma chuanxiong, flos carthami, radix salviae miltiorrhizae and the like have the effects of promoting blood circulation, dredging collaterals, dispelling wind and relieving pain, nasal cavity blood circulation can be improved, and nasal obstruction symptoms can be relieved; selfheal, thunberg fritillary bulb, pseudobulbus cremastrae seu pleiones and the like can clear heat, dissipate stagnation, diminish swelling, detoxify and relieve allergic symptoms such as nasal cavity inflammation, rhinocnesmus and sneezing; cornu cervi degelatinatum, radix aconiti carmichaeli, centipede and the like have the effects of warming yang, dispelling cold, activating meridians and relieving pain, and can quickly relieve nose pain; ground beeltle, pseudo-ginseng powder and the like can promote blood circulation to remove blood stasis, promote inflammation absorption and further relieve pain; the traditional Chinese medicine composition adopts natural traditional Chinese medicinal materials, is reasonable in compatibility, reduces side effects on human bodies while ensuring effects, and is small in irritation to nasal mucosa; the preparation process adopts conventional extraction, crushing, mixing, filtering and other processes, is simple and convenient to operate, and is easy for industrial production.

Description

Technical Field

[0001] The invention belongs to the technical field of rhinitis treatment, and specifically refers to a spray for treating rhinitis symptoms and quickly relieving pain. Background Art

[0002] Rhinitis is a common nasal disease with a high incidence rate worldwide. Rhinitis is mainly an inflammation of the nasal mucosa caused by viruses, bacteria, allergens (such as pollen, dust mites, etc.), various physical and chemical factors (such as irritating gases, cold air, etc.) and certain systemic diseases. Its pathogenesis is relatively complex, involving multiple aspects such as overactivation of the immune system, release of inflammatory mediators, and physiological dysfunction of the nasal mucosa. For example, when allergens enter the nasal cavity, they activate the body's immune cells and release inflammatory mediators such as histamine and leukotrienes. These mediators can cause vasodilation and increased permeability of the nasal mucosa, which in turn causes a series of symptoms such as nasal congestion, runny nose, itchy nose, sneezing, etc., which seriously affect the patient's quality of life.

[0003] There are many kinds of drugs for the treatment of rhinitis on the market, including oral drugs, nasal glucocorticoids, decongestants, etc., but these drugs have certain limitations. Oral drugs need to be absorbed through the gastrointestinal tract, and the drugs must first pass through the first-pass effect of the liver. Not only are they relatively slow to take effect, but they may also irritate the gastrointestinal tract, causing adverse reactions such as nausea, vomiting, and loss of appetite; although nasal glucocorticoids can effectively reduce inflammatory responses, long-term use may cause side effects such as nasal mucosal atrophy, nosebleeds, and systemic absorption of hormones; if decongestants are used improperly, such as for too long or in excessive doses, they can easily cause drug-induced rhinitis, making the condition more complicated and difficult to treat. In addition, when rhinitis attacks, patients often have nasal pain due to inflammatory stimulation of the nasal mucosa and increased sensitivity of nerve endings. However, existing drugs are not effective in rapid pain relief and cannot meet patients' urgent needs for pain relief. Therefore, the development of a safe and effective spray that can quickly regulate rhinitis symptoms and relieve pain has important clinical significance and market demand. Summary of the invention

[0004] The invention aims to provide a spray for regulating rhinitis symptoms and quickly relieving pain. The clematis root, chuanxiong, safflower, salvia miltiorrhiza and the like in the invention have the effects of promoting blood circulation, unblocking meridians, dispelling wind and relieving pain, and are helpful to improve nasal blood circulation and relieve nasal congestion symptoms; herba prunellae, fritillaria thunbergii, trillium and the like can clear away heat, dissipate stagnation, reduce swelling and detoxify, and can relieve nasal inflammation and allergic symptoms such as nasal itching and sneezing; antler frost, aconite root, centipede and the like have the effects of warming yang, dispelling cold, unblocking meridians and relieving pain, and can quickly relieve nasal pain; ground beetle, panax notoginseng powder and the like can promote blood circulation and remove blood stasis, promote inflammation absorption, and further relieve pain; the invention adopts natural Chinese medicinal materials and is reasonably compatible, and while ensuring efficacy, reduces side effects on human body and has little irritation to nasal mucosa; the preparation process of the invention adopts conventional extraction, crushing, mixing, filtering and the like processes, is simple to operate, and is easy to industrialize.

[0005] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: a spray for regulating rhinitis symptoms and quickly relieving pain, the spray comprising the following components in parts by weight: 1-15 parts of clematis, 1-10 parts of antler frost, 1-9 parts of sappan wood, 1-12 parts of selfheal, 1-9 parts of earthworm, 1-13 parts of green peel, 1-12 parts of chuanxiong, 1-10 parts of tiankui seeds, 1-9 parts of earthworm, 1-10 parts of mirabilite, 1-9 parts of arisaema, 2-10 parts of dioscorea bulbifera, 1-10 parts of momordica seed, 1-15 parts of thunbergii bulb, 2-12 parts of fenugreek, 2-15 parts of kelp, 2-13 parts of trillium, 1-8 parts of centipede, 1-10 parts of safflower, 1-12 parts of salvia miltiorrhiza, 1-9 parts of zanthoxylum, 1-7 parts of aconite, and 1-11 parts of notoginseng powder.

[0006] Preferably, the spray comprises the following components in parts by weight: 2-10 parts of clematis, 2-8 parts of antler powder, 2-8 parts of sappan wood, 2-10 parts of selfheal, 1-7 parts of earthworm, 2-9 parts of green peel, 1-10 parts of chuanxiong, 2-9 parts of tiankui seeds, 2-8 parts of earthworm, 1-5 parts of sodium sulfate, 2-8 parts of arisaema, 3-9 parts of dioscorea bulbifera, 2-5 parts of momordica seeds, 4-9 parts of thunbergii bulb, 3-9 parts of fenugreek, 4-10 parts of kelp, 3-9 parts of tribulus ternata, 1-5 parts of centipede, 2-10 parts of safflower, 3-10 parts of salvia miltiorrhiza, 1-7 parts of zanthoxylum bungeanum, 1-5 parts of aconite, and 1-7 parts of notoginseng powder.

[0007] Preferably, the spray comprises the following components in parts by weight: 3-8 parts of clematis, 2-6 parts of antler frost, 3-7 parts of sappan wood, 4-9 parts of selfheal, 2-5 parts of earthworm, 3-6 parts of green peel, 2-5 parts of chuanxiong, 3-7 parts of tiankui seeds, 2-4 parts of earthworm, 1-3 parts of sodium sulfate, 2-5 parts of arisaema, 3-6 parts of dioscorea bulbifera, 2-4 parts of momordica seeds, 4-8 parts of thunbergii bulb, 3-7 parts of fenugreek, 4-8 parts of kelp, 3-6 parts of tribulus ternata, 1-3 parts of centipede, 3-7 parts of safflower, 4-9 parts of salvia miltiorrhiza, 2-5 parts of zanthoxylum bungeanum, 1-3 parts of aconite, and 2-5 parts of notoginseng powder.

[0008] The present invention also provides a method for preparing a spray for regulating rhinitis symptoms and quickly relieving pain, the preparation method comprising the following steps:

[0009] (1) Wash clematis root, sappan wood, green peel, ligusticum chuanxiong, arisaema, radix dioscoreae, momordica charantia, kelp, safflower, salvia miltiorrhiza, zanthoxylum bungeanum, and aconite root, dry and grind into coarse powder, extract with extracting solution for 2-3 times, each time for 1.5-2.5 hours, combine the extracting solutions, and concentrate under reduced pressure to obtain an extract;

[0010] (2) Drying the herb Prunella Vulgaris, Gastrodia elata, Vaccaria segetalis, Psoralea corylifolia, Pheretima chinensis, and Eupolyphaga sinensis at low temperature, and then crushing the powder into fine powder, sifting through a sieve, and setting aside for use;

[0011] (3) Grind the antler powder, mirabilite, Fritillaria thunbergii, centipede, and Panax notoginseng powder into very fine powder, sieve through a sieve, and set aside;

[0012] (4) Add the extract to an appropriate amount of purified water, stir evenly, then add fine powder and ultrafine powder in sequence, stir evenly, dilute to the required volume with purified water, stir evenly, and filter with a 0.22 μm microporous filter membrane to obtain the spray of the present invention.

[0013] Preferably, the extract in step (1) is a 60%-80% ethanol solution.

[0014] Preferably, the relative density of the extract in step (1) is 1.12-1.22.

[0015] Preferably, the mesh size of the sieve in step (2) is 100-120 meshes.

[0016] Preferably, the mesh size of the sieve in step (3) is 200-300 mesh.

[0017] The beneficial effects achieved by the present invention using the above structure are as follows: (1) the Clematis chinensis, Chuanxiong, Carthamus tinctorius, Salvia miltiorrhiza and the like in the present invention have the effects of promoting blood circulation, unblocking meridians, dispelling wind and relieving pain, which are helpful to improve nasal blood circulation and relieve nasal congestion symptoms; Prunella vulgaris, Fritillaria thunbergii, Tripterygium wilfordii and the like can clear away heat, dissipate stagnation, reduce swelling and detoxify, and can relieve nasal inflammation and allergic symptoms such as nasal itching and sneezing; Deer antler frost, Aconitum carmichaelii, Scolopendra subspinipes and the like have the effects of warming yang, dispelling cold, unblocking meridians and relieving pain, and can quickly relieve nasal pain; Eupolyphaga sinensis, Panax notoginseng powder and the like can promote blood circulation and remove blood stasis, promote inflammation absorption, and further relieve pain; (2) the present invention adopts natural Chinese medicinal materials and reasonably combines them, which reduces the side effects on the human body while ensuring the efficacy, and has little irritation to the nasal mucosa; (3) the preparation process of the present invention adopts conventional extraction, crushing, mixing, filtering and other processes, which is simple to operate and easy to industrialize. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 Rhinitis symptom score.

[0019] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0021] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0022] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0023] Example 1

[0024] A spray for regulating rhinitis symptoms and quickly relieving pain

[0025] The spray comprises the following components in parts by weight: 3 parts of clematis, 6 parts of antler frost, 3 parts of sappan wood, 9 parts of selfheal, 2 parts of earthworm, 6 parts of green peel, 2 parts of chuanxiong, 7 parts of tiankui seeds, 2 parts of earthworm, 3 parts of sodium sulfate, 2 parts of arisaema, 6 parts of dioscorea bulbifera, 2 parts of momordica seeds, 8 parts of thunbergii bulb, 3 parts of fenugreek, 8 parts of kelp, 3 parts of tribulus ternata, 3 parts of centipede, 3 parts of safflower, 9 parts of salvia miltiorrhiza, 2 parts of zanthoxylum bungeanum, 3 parts of aconite, and 2 parts of notoginseng powder.

[0026] The present invention also provides a method for preparing a spray for regulating rhinitis symptoms and quickly relieving pain, the preparation method comprising the following steps:

[0027] (1) Wash clematis root, sappan wood, green peel, ligusticum chuanxiong, arisaema, radix dioscoreae, momordica charantia, kelp, safflower, salvia miltiorrhiza, zanthoxylum bungeanum, and aconite root, dry and grind into coarse powder, extract with extracting solution for 2-3 times, each time for 1.5-2.5 hours, combine the extracting solutions, and concentrate under reduced pressure to obtain an extract;

[0028] (2) Drying the herb Prunella Vulgaris, Gastrodia elata, Vaccaria segetalis, Psoralea corylifolia, Pheretima chinensis, and Eupolyphaga sinensis at low temperature, and then crushing the powder into fine powder, sifting through a sieve, and setting aside for use;

[0029] (3) Grind the antler powder, mirabilite, Fritillaria thunbergii, centipede, and Panax notoginseng powder into very fine powder, sieve through a sieve, and set aside;

[0030] (4) Add the extract to an appropriate amount of purified water, stir evenly, then add fine powder and ultrafine powder in sequence, stir evenly, dilute to the required volume with purified water, stir evenly, and filter with a 0.22 μm microporous filter membrane to obtain the spray of the present invention.

[0031] Wherein, the extract in step (1) is a 60%-80% ethanol solution.

[0032] Wherein, the relative density of the extract in step (1) is 1.12-1.22.

[0033] Wherein, the mesh size of the sieve in step (2) is 100-120 meshes.

[0034] Wherein, the mesh size of the sieve in step (3) is 200-300 mesh.

[0035] Example 2

[0036] A spray for regulating rhinitis symptoms and quickly relieving pain

[0037] The spray comprises the following components in parts by weight: 8 parts of clematis, 2 parts of antler frost, 7 parts of sappan wood, 4 parts of selfheal, 5 parts of earthworm, 3 parts of green peel, 5 parts of chuanxiong, 3 parts of tiankui seeds, 4 parts of earthworm, 1 part of sodium sulfate, 5 parts of arisaema, 3 parts of dioscorea bulbifera, 4 parts of momordica seeds, 4 parts of thunbergia thunbergii, 7 parts of fenugreek, 4 parts of kelp, 6 parts of tribulus ternata, 1 part of centipede, 7 parts of safflower, 4 parts of salvia miltiorrhiza, 5 parts of zanthoxylum bungeanum, 1 part of aconite, and 5 parts of notoginseng powder.

[0038] The present invention also provides a method for preparing a spray for regulating rhinitis symptoms and quickly relieving pain, and the preparation method is carried out with reference to Example 1.

[0039] Example 3

[0040] A spray for regulating rhinitis symptoms and quickly relieving pain, the spray comprising the following components in parts by weight: 5 parts of clematis, 4 parts of antler frost, 5 parts of sappan wood, 6 parts of selfheal, 3 parts of earthworm, 5 parts of green peel, 3 parts of chuanxiong, 5 parts of tiankui seeds, 3 parts of earthworm, 2 parts of sodium sulfate, 3 parts of arisaema, 4 parts of dioscorea bulbifera, 3 parts of momordica seeds, 6 parts of thunbergii bulb, 5 parts of fenugreek, 6 parts of kelp, 5 parts of tribulus ternata, 2 parts of centipede, 5 parts of safflower, 7 parts of salvia miltiorrhiza, 4 parts of zanthoxylum bungeanum, 2 parts of aconite, and 3 parts of notoginseng powder.

[0041] The present invention also provides a method for preparing a spray for regulating rhinitis symptoms and quickly relieving pain, and the preparation method is carried out with reference to Example 1.

[0042] Experimental Example 1

[0043] Effect of a spray for regulating rhinitis symptoms and quickly relieving pain

[0044] 120 patients with rhinitis were selected and randomly divided into 4 groups, 30 cases in each group; respectively, the control group (using a well-known commercial nasal spray), Example 1 group, Example 2 group, and Example 3 group. The selected patients all met the diagnostic criteria for rhinitis, and had not used other drugs for the treatment of rhinitis in the past month, excluding those who were allergic to the components of the spray of the present invention, pregnant women and lactating women, and those with severe cardiovascular and cerebrovascular diseases and liver and kidney dysfunction; the control group used commercially available nasal sprays and used them according to the instructions; Example 1-3 groups used the sprays prepared by Example 1-3 of the present invention, sprayed 3-4 times a day, sprayed 2-3 times on each side of the nasal cavity each time, and used continuously for 2 weeks. During the trial, patients were required to record the daily symptom changes, and any other drugs or treatment methods that may affect the test results were prohibited; the improvement of symptoms such as nasal congestion, runny nose, nasal itching, sneezing, and nasal pain before and after treatment was observed and recorded, and evaluated by symptom scoring (no symptoms were scored as 0 points, mild scores were scored as 1 point, moderate scores were scored as 2 points, and severe scores were scored as 3 points).

[0045] Result analysis: Figure 1 As shown, the symptom scores of patients in Example 1-3 groups were significantly lower than those in the control group, and among the Example 1-3 groups, the Example 3 group had the best comprehensive effect and the symptom improvement of the patients was the most obvious.

[0046] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0047] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A spray for treating rhinitis symptoms and quickly relieving pain, characterized in that: The spray comprises the following components in parts by weight: 1-15 parts of clematis, 1-10 parts of antler frost, 1-9 parts of sappan wood, 1-12 parts of selfheal, 1-9 parts of earthworm, 1-13 parts of green peel, 1-12 parts of ligusticum chuanxiong, 1-10 parts of smilax glabra, 1-9 parts of earthworm, 1-10 parts of sodium sulfate, 1-9 parts of arisaema, 2-10 parts of Dioscorea bulbifera, 1-10 parts of Momordica cochinchinensis, 1-15 parts of Fritillaria thunbergii, 2-12 parts of fenugreek, 2-15 parts of kelp, 2-13 parts of tribulus ternata, 1-8 parts of centipede, 1-10 parts of safflower, 1-12 parts of salvia miltiorrhiza, 1-9 parts of zanthoxylum bungeanum, 1-7 parts of aconite, and 1-11 parts of notoginseng powder.

2. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 1, characterized in that: The spray comprises the following components in parts by weight: 2-10 parts of clematis, 2-8 parts of antler frost, 2-8 parts of sappan wood, 2-10 parts of selfheal, 1-7 parts of earthworm, 2-9 parts of green peel, 1-10 parts of ligusticum chuanxiong, 2-9 parts of siamensis seeds, 2-8 parts of earthworm, 1-5 parts of sodium sulfate, 2-8 parts of arisaema, 3-9 parts of Dioscorea bulbifera, 2-5 parts of Momordica cochinchinensis, 4-9 parts of thunbergii bulb, 3-9 parts of fenugreek, 4-10 parts of kelp, 3-9 parts of tribulus ternata, 1-5 parts of centipede, 2-10 parts of safflower, 3-10 parts of salvia miltiorrhiza, 1-7 parts of zanthoxylum bungeanum, 1-5 parts of aconite, and 1-7 parts of notoginseng powder.

3. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 2, characterized in that: The spray comprises the following components in parts by weight: 3-8 parts of clematis, 2-6 parts of antler frost, 3-7 parts of sappan wood, 4-9 parts of selfheal, 2-5 parts of earthworm, 3-6 parts of green peel, 2-5 parts of ligusticum chuanxiong, 3-7 parts of siamensis seeds, 2-4 parts of earthworm, 1-3 parts of sodium sulfate, 2-5 parts of arisaema, 3-6 parts of Dioscorea bulbifera, 2-4 parts of Momordica charantia, 4-8 parts of thunbergii bulb, 3-7 parts of fenugreek, 4-8 parts of kelp, 3-6 parts of tribulus ternata, 1-3 parts of centipede, 3-7 parts of safflower, 4-9 parts of salvia miltiorrhiza, 2-5 parts of zanthoxylum bungeanum, 1-3 parts of aconite, and 2-5 parts of notoginseng powder.

4. A method for preparing a spray for treating rhinitis symptoms and quickly relieving pain according to claim 3, characterized in that: The preparation method comprises the following steps: (1) Wash clematis root, sappan wood, green peel, ligusticum chuanxiong, arisaema, radix dioscoreae, momordica charantia, kelp, safflower, salvia miltiorrhiza, zanthoxylum bungeanum, and aconite root, dry and grind into coarse powder, extract with extracting solution for 2-3 times, each time for 1.5-2.5 hours, combine the extracting solutions, and concentrate under reduced pressure to obtain an extract; (2) Drying the herb Prunella Vulgaris, Gastrodia elata, Vaccaria segetalis, Psoralea corylifolia, Pheretima chinensis, and Eupolyphaga sinensis at low temperature, and then crushing the powder into fine powder, sifting through a sieve, and setting aside for use; (3) Grind the antler powder, mirabilite, Fritillaria thunbergii, centipede, and Panax notoginseng powder into very fine powder, sieve through a sieve, and set aside; (4) Add the extract to an appropriate amount of purified water, stir evenly, then add fine powder and ultrafine powder in sequence, stir evenly, dilute to the required volume with purified water, stir evenly, and filter with a 0.22 μm microporous filter membrane to obtain the spray of the present invention.

5. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 4, characterized in that: The extract in step (1) is a 60%-80% ethanol solution.

6. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 5, characterized in that: The relative density of the extract in step (1) is 1.12-1.

22.

7. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 6, characterized in that: The mesh size of the sieve in step (2) is 100-120 meshes.

8. A spray for treating rhinitis symptoms and quickly relieving pain according to claim 7, characterized in that: The mesh size of the sieve in step (3) is 200-300 mesh.

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