Medicinal and edible composition and application thereof

Abstract

The invention provides a medicinal and edible dual-purpose composition, which is prepared from the following raw materials in parts by weight: 100 to 400 parts of Zhongning fructus lycii, 10 to 50 parts of radix ginseng, 10 to 50 parts of cornu cervi pantotrichum, 20 to 80 parts of rhizoma polygonati, 20 to 80 parts of herba dendrobii, 10 to 50 parts of cortex lycii radicis, 0.5 to 2 parts of herba glechomae, 2 to 6 parts of herba eriobotryae, 2 to 6 parts of fructus lycii carpopodium and 10 to 50 parts of herba epimedii. According to the composition, traditional Chinese medicinal materials with homology of medicine and food are adopted as the components, the multiple components have a synergistic effect, Zhongning fructus lycii and ginseng serve as monarch drugs, cornu cervi pantotrichum serves as a substance with blood and meat and is mainly used for drastically supplementing essence, and the cornu cervi pantotrichum is matched with fructus lycii and ginseng and can tonify qi to strengthen yang and generate essence, yang qi is long and essence is generated, healthy qi is vigorous, namely healthy qi is stored in the interior, evil cannot be dried, and all diseases cannot be generated; the purpose of preventing diseases is achieved.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine preparations, and particularly relates to a medicinal and edible composition having the effects of improving hypertension, hyperlipidemia, and hyperglycemia. Background Art

[0002] Hypertension, hyperlipidemia, and hyperglycemia are some of the most common chronic diseases globally, and are risk factors for cardiovascular and cerebrovascular diseases, chronic renal failure, retinopathy, and periodontal diseases, often leaving doctors and patients helpless. Therefore, it is necessary to develop a safe, effective, and practical product.

[0003] Existing drug treatment methods only control and cannot completely cure, and have large side effects. As the disease duration increases, patients take more and more medications, and the drug control effect will continuously decline. It is imperative to develop a safe and effective product. Summary of the Invention

[0004] Aiming at the deficiencies existing in the prior art, the purpose of the present invention is to provide a medicinal and edible composition.

[0005] The present invention provides a medicinal and edible composition, and according to parts by weight, the composition comprises the following raw materials: 100 - 400 parts of Ningxia wolfberry, 10 - 50 parts of ginseng, 10 - 50 parts of pilose antler, 20 - 80 parts of polygonatum sibiricum, 20 - 80 parts of dendrobium officinale, 10 - 50 parts of cortex lycii radicis, 0.5 - 2 parts of sedum aizoon, 2 - 6 parts of herba euphorbiae humifusae, 2 - 6 parts of wolfberry stalks, 10 - 50 parts of epimedium brevicornum.

[0006] Preferably, for the medicinal and edible composition of the present invention, according to parts by weight, the composition comprises the following raw materials: 250 parts of Ningxia wolfberry, 25 parts of ginseng, 25 parts of pilose antler, 50 parts of polygonatum sibiricum, 50 parts of dendrobium officinale, 25 parts of cortex lycii radicis, 1 part of sedum aizoon, 4 parts of herba euphorbiae humifusae, 4 parts of wolfberry stalks, 25 parts of epimedium brevicornum.

[0007] Explanation of the Formula Ningxia wolfberry has a sweet taste and a neutral nature, benefits the liver and kidneys, and nourishes essence and blood. This product enters the liver and kidney meridians, is good at nourishing the kidney yin, tonifying the liver blood, improving eyesight and calming the mind, and is a product for gently tonifying the deficiency of liver and kidney essence and blood. "Compendium of Materia Medica" states that "this product is an important medicine for tonifying the deficiency of true yin of the liver and kidneys and relieving internal heat due to fatigue." It is mainly used for treating symptoms such as soreness and weakness of the waist and knees, unclear eyesight, and premature whitening of hair caused by deficiency of liver and kidney essence and blood. "Treasure of Life" uses this product to make ointment.

[0008] Ginseng has a sweet taste and a warm nature, greatly tonifies primordial qi, can not only tonify qi but also promote the production of body fluid when combined with wolfberry. It is used for qi and body fluid depletion, deficiency of primordial qi, and deficiency of qi and blood. This product enters the spleen, lung, heart, and kidney meridians, and thus has a tonifying effect on all deficient viscera.

[0009] Deer antler velvet is sweet and salty in taste, warm in nature, and belongs to the liver and kidney meridians. This product has the nature of pure yang and the qi of growth. When the human body is deficient in blood and fails to recover for a long time, it will necessarily damage the kidney yin. When the kidney yin is lacking, it will necessarily lead to yang deficiency. Therefore, it can tonify the kidney yang and benefit essence and blood. It is applicable to impotence and spermatorrhea, infertility due to kidney deficiency, fatigue, and involuntary urination caused by deficiency of kidney yang. Also, because this product can both tonify the kidney yang and strengthen the bones and muscles, it is often used to treat bone weakness and flaccidity of the bones and muscles due to kidney deficiency.

[0010] Polygonatum sibiricum: It is sweet in taste and neutral in nature, beneficial to the kidney, moistening the lungs, strengthening the spleen, and nourishing qi and yin. This product can both tonify the qi of the spleen and lungs and nourish the yin of the spleen and lungs, and also tonify the kidney essence, and can guide the medicine into the spleen, lungs, and kidney meridians of the human body. It is mainly used to treat qi deficiency of the spleen and stomach, deficiency of the liver and kidneys, deficiency of essence and blood, soreness and weakness of the waist and knees, early whitening of the hair and beard, loss of appetite, fatigue, etc.

[0011] Lycium chinense Mill. Root-bark: It is sweet in taste and cold in nature, and belongs to the lung, liver, and kidney meridians. It can both cool the blood and relieve vexation and clear the lung and reduce fire. This product is sweet, cold, and moistening, can clear heat and purge fire to generate fluid and quench thirst, is good at clearing deficiency heat and removing steaming bone fever, and treats yin deficiency fever, night sweats, etc. It is an excellent product for cooling the blood, reducing fever, and relieving vexation. "Shennong Ben Cao Jing" says: Lycium barbarum "maintains the five internal pathogens, heat in the middle with thirst, and general pain of the muscles and joints." Dendrobium officinale: It is sweet and cold in taste, and belongs to the stomach meridian and kidney meridian. This product can both benefit the stomach and promote the production of body fluid and clear heat and moisten. It is good at nourishing the stomach yin, quenching thirst and promoting the production of body fluid. It can both nourish the kidney yin and reduce the asthenic fire, and specifically treats dizziness and unclear vision due to kidney yin deficiency, flaccidity of the bones and muscles, and asthenic fire flaming upward with steaming bone fever, etc. Adding this product to this prescription can prevent some people from getting angry after taking this medicinal paste.

[0012] Epimedium brevicornum Maxim.: It is pungent and sweet in taste, warm in nature, and belongs to the liver and kidney meridians. This product tonifies the kidney and strengthens yang, and strengthens the bones and muscles. Its nature is dry and strong, and it is good at tonifying the kidney yang and strengthening the bones to relieve flaccidity. It is used for men with impotence and infertility, and those with weak bones and muscles suffering from rheumatic arthralgia.

[0013] Fruit stalk of Lycium barbarum, Tianjingcao, Changshengcao: Li Shizhen of the Ming Dynasty wrote in "Compendium of Materia Medica" quoting [Zong Shi said]: "For Lycium barbarum, the stem bark should be used; for Lycium chinense Mill., the root bark should be used; for the fruit, the red fruits should be used. Its bark is extremely cold, and the fruit is slightly cold." "It treats the internal pathogens in the house, heat in the middle with thirst, and general pain of the muscles and joints due to rheumatism. Taking it for a long time can strengthen the bones and muscles, make the body light and not age, and withstand cold and heat." "It relieves the qi in the chest and hypochondrium, treats headache due to exogenous heat, supplements the great fatigue and shortness of breath due to internal injury, strengthens the yin, and benefits the large and small intestines." "It supplements all deficiencies of essence and qi, changes the complexion, turns white, improves eyesight and soothes the mind, and makes people live long." This refers to the combined effects of using the root, seedling, flower, and fruit of Lycium barbarum together. "Compendium of Materia Medica" also quotes: "The "Huainan Pillow Book" records the method of taking Lycium barbarum by the Western River woman: Pick the root on the first day of the first lunar month, and process and take it on the second day of the second lunar month; pick the stem on the first day of the third lunar month, and process and take it on the fourth day of the fourth lunar month; pick the leaves on the first day of the fifth lunar month, and process and take it on the second day of the sixth lunar month; pick the flowers on the first day of the seventh lunar month, and process and take it on the fourth day of the eighth lunar month; pick the fruits on the first day of the ninth lunar month, and process and take it on the fourth day of the tenth lunar month; pick the root on the first day of the eleventh lunar month, and process and take it on the second day of the twelfth lunar month. There are also those who make decoctions with the flowers, fruits, roots, stems, and leaves, or extract the juice of the fruits alone to make a paste and take it. Their effects are the same. Pick the leaves of Lycium barbarum in spring, which is called Tianjingcao; pick the flowers in summer, which is called Changshengcao; pick the fruits in autumn, which is called Goji berries; pick the roots in winter, which is called Lycium chinense Mill. Root-bark. Therefore, every part of Lycium barbarum is a treasure, so there is a saying of 'nothing is wasted'."

[0014] The present invention also provides the use of the above-mentioned dual-purpose medicine and food composition in the preparation of hypoglycemic drugs.

[0015] The present invention also provides the use of the above-mentioned dual-purpose medicine and food composition in the preparation of hypolipidemic drugs.

[0016] The present invention also provides the use of the above-mentioned dual-purpose medicine and food composition in the preparation of hypotensive drugs.

[0017] The beneficial effects of the present invention include but are not limited to: 1. In the composition of the present invention, traditional Chinese medicinal materials that are both medicine and food are used as components, and multiple components act synergistically with each other. Chinese wolfberry from Zhongning and ginseng are the monarch drugs, and pilose antler is a substance with vital essence, mainly replenishing the marrow severely. Matched with Chinese wolfberry and ginseng, it can tonify qi, assist yang, and generate essence. When yang qi grows, marrow essence is generated, and when healthy qi is strong, that is, when healthy qi exists inside the body, pathogenic factors cannot invade, and all diseases will not occur, achieving the purpose of preventing diseases. Among them, the monarch drugs, Chinese wolfberry and ginseng, play a major role in treating the main syndromes. The dosage of Chinese wolfberry in this formula is the largest. Combined with ginseng, one is yin and the other is yang, one is qi and the other is blood, complementing each other's strengths and weaknesses. The ministerial drugs, pilose antler and polygonatum sibiricum, rank second only to the monarch drugs in this composition. It can strengthen the treatment of the main syndromes by the monarch drugs and assist the monarch drugs in solving the main contradictions. The adjuvant drugs, dendrobium officinale and epimedium brevicornu, rank second only to the ministerial drugs in this composition, which can strengthen the synergistic effect between the monarch and ministerial drugs, and solve or eliminate the excessive or insufficient reactions of the monarch and ministerial drugs. (For example, some people may have symptoms of getting angry after taking the paste), and it can play a role in regulating the cold-heat balance between drugs. The envoy drugs, cortex lycii radicis, sedum sarmentosum bunge, herba euphorbiae humifusae, and wolfberry fruit stalk are of the same root as the monarch drug, Chinese wolfberry, which can enhance and exert various functions and effects of Chinese wolfberry, and can play multiple roles of mediation, guiding the drug to the meridian, and enhancing the curative effect.

[0018] 2. It can be verified through experiments that the dual-purpose medicine and food composition of the present application has the effects of hypoglycemia, hypolipidemia, and hypotension, and also has the effects of tonifying the liver and kidney, nourishing yin and filling essence, replenishing qi and strengthening yang, generating marrow and strengthening bones, warming yang and promoting qi transformation, opening orifices and improving eyesight, strengthening the spleen and nourishing the lungs, and enhancing memory, and can effectively improve the disease resistance of the human body. Specific Embodiments

[0020] The present invention will be described in detail below in conjunction with specific embodiments. The following embodiments are only for the convenience of those skilled in the art to understand the technical solution of the present invention and to illustrate the implementation or use of the present invention, and do not limit the protection scope of the present invention.

[0021] In the present invention, unless otherwise specified, the raw materials and equipment used can be purchased from the market or are commonly used in the art. The methods in the embodiments are conventional methods in the art unless otherwise specified.

[0022] Example 1 A medicine and food dual-purpose composition includes the following raw materials by weight: 200 parts of Ningxia wolfberry, 20 parts of ginseng, 50 parts of pilose antler, 20 parts of polygonatum sibiricum, 50 parts of dendrobium officinale, 50 parts of cortex lycii radicis, 1 part of sedum aizoon, 2 parts of herba lysimachiae, 6 parts of wolfberry fruit stalks, and 20 parts of epimedium brevicornum.

[0023] Add the said components to water with a mass 3 times that of the components, decoct for 3 times, 2 hours each time, combine the supernatant liquids of the 3 times and clarify for 3 hours; according to the traditional ancient method of making paste process, boil, concentrate, and collect the paste to finally make a paste.

[0024] Example 2 A medicine and food dual-purpose composition includes the following raw materials by weight: 250 parts of Ningxia wolfberry, 25 parts of ginseng, 25 parts of pilose antler, 50 parts of polygonatum sibiricum, 50 parts of dendrobium officinale, 25 parts of cortex lycii radicis, 1 part of sedum aizoon, 4 parts of herba lysimachiae, 4 parts of wolfberry fruit stalks, and 25 parts of epimedium brevicornum.

[0025] Add the said components to water with a mass 5 times that of the components, decoct for 3 times, 2 hours each time, combine the supernatant liquids of the 3 times and clarify for 3 hours; according to the traditional ancient method of making paste process, boil, concentrate, and collect the paste to finally make a paste. The traditional empirical method for judging the paste is to observe that during the heating and boiling process, the paste boils in a honeycomb shape, or the concentrated paste can form a flagging phenomenon on the spatula or drop into beads when dripping water, which indicates that the paste is successful. Immediately remove the paste from the stove and transfer it to the paste cooling room for packaging.

[0026] Example 3 A medicine and food dual-purpose composition includes the following raw materials by weight: 100 parts of Ningxia wolfberry, 50 parts of ginseng, 10 parts of pilose antler, 80 parts of polygonatum sibiricum, 40 parts of dendrobium officinale, 10 parts of cortex lycii radicis, 2 parts of sedum aizoon, 5 parts of herba lysimachiae, 5 parts of wolfberry fruit stalks, and 50 parts of epimedium brevicornum.

[0027] Add the said components to water with a mass 3 times that of the components, decoct for 3 times, 2 hours each time, combine the supernatant liquids of the 3 times and clarify for 3 hours; according to the traditional ancient method of making paste process, boil, concentrate, and collect the paste to finally make a paste.

[0028] Example 4 A medicine and food dual-purpose composition includes the following raw materials by weight: 300 parts of Ningxia wolfberry, 20 parts of ginseng, 25 parts of pilose antler, 50 parts of polygonatum sibiricum, 80 parts of dendrobium officinale, 25 parts of cortex lycii radicis, 0.5 part of sedum aizoon, 6 parts of herba lysimachiae, 3 parts of wolfberry fruit stalks, and 10 parts of epimedium brevicornum.

[0029] Add the said components to water with a mass 3 times that of the components, decoct for 2 times, 2 hours each time, combine the supernatant liquids of the 2 times and clarify for 3 hours; according to the traditional ancient method of making paste process, boil, concentrate, and collect the paste to finally make a paste.

[0030] Example 5 A medicine and food dual-purpose composition, comprising the following raw materials by weight: 400 parts of Chinese wolfberry from Zhongning, 10 parts of ginseng, 50 parts of pilose antler, 60 parts of polygonatum sibiricum, 20 parts of dendrobium officinale, 35 parts of cortex lycii radicis, 1 part of sedum aizoon, 4 parts of heavenly essence grass, 4 parts of wolfberry fruit stalks, and 30 parts of epimedium brevicornum.

[0031] Add the above components to water with a mass 3 times that of them, decoct for 3 times, 2 hours each time, combine the supernatant of the 3 times and clarify for 3 hours; according to the traditional ancient method of making paste, boil, concentrate, and collect the paste to finally make a paste.

[0032] Use the medicine and food dual-purpose composition prepared in Example 2 above for the following test cases.

[0033] Case report: 1. Patient: Wang, female, 50 years old, from Zhongning, Ningxia. She had insomnia for three years, listlessness, soreness and weakness in the waist and knees, fatigue in the limbs, memory loss, dizziness and tinnitus, blood pressure of 155 / 105 mmHg, high blood lipid (triglyceride) of 3.6 mmol / L, and high blood sugar of 7.8 mmol / L. According to traditional Chinese medicine diagnosis, it was spleen-kidney deficiency and qi-blood deficiency. After taking the paste of this application for 1 month, the insomnia symptoms gradually improved, the soreness in the waist and knees disappeared, the limbs became strong, the memory was significantly enhanced, the blood pressure dropped to 135 / 95 mmHg, the blood lipid (triglyceride) was 3.1 mmol / L, and the high blood sugar was 6.9 mmol / L. After taking it for three months, the fatigue disappeared. After continuously taking it for half a year, all the above symptoms completely disappeared, the blood pressure was 125 / 85 mmHg, the blood lipid (triglyceride) was 2.2 mmol / L, and the blood sugar was 6.0 mmol / L.

[0034] Case report: 2. Patient: Zhang, female, 29 years old, from Zhongning, Ningxia, with a postgraduate degree, working in a Sino-Japanese joint venture in Beijing. Due to excessive work pressure and mental stress, she had insomnia for more than one year, accompanied by dizziness, headache, palpitation, restlessness, poor appetite, memory loss, fatigue, scanty menstruation, pale tongue and weak pulse. She went to the local hospital for treatment and was diagnosed with depression. After various treatments, the effect was not good, so she took leave to go back to Ningxia for treatment. Using traditional Chinese medicine for conditioning, the diagnosis was heart-spleen deficiency and liver qi stagnation. After taking 10 doses of traditional Chinese medicine decoction with modified Guipi Decoction plus Xiaoyao Powder, the sleep improved. Later, she changed to the paste of this application for further conditioning. After taking the paste for 1 month, the sleep was okay, and the dizziness and fatigue were significantly reduced. After continuously taking the paste for half a year, the above symptoms disappeared and the body recovered to health and could work normally.

[0035] Case Report: 3. Patient: Wang XX, male, 59 years old, from Zhongning, Ningxia. He had mental fatigue, weakness in the limbs, memory loss accompanied by dizziness, palpitations, and anorexia for nearly one year. His blood pressure was 165 / 110 mmHg, blood lipid (triglyceride) was 3.5 mmol / L, and blood glucose was 6.8 mmol / L. After being examined by multiple hospitals in one year, all other indicators were normal except for hypertension, hyperglycemia, and hyperlipidemia. Then traditional Chinese medicine was used for conditioning. According to traditional Chinese medicine syndrome differentiation, it was liver qi stagnation. After taking traditional Chinese medicine decocted from Xiaoyao Powder with modifications for 1 week, the mental fatigue was relieved. Then, after taking the paste-like pharmaceutical composition (paste formula) of this application for conditioning for 1 month, dizziness, palpitations, anorexia, and weakness in the limbs improved significantly. The blood pressure was 155 / 100 mmHg, blood lipid (triglyceride) was 3.0 mmol / L, and blood glucose was 6.8 mmol / L. Continuously using the paste-like pharmaceutical composition (paste formula) of this application for conditioning and rehabilitation, after taking the paste for half a year, the body recovered to health. The blood pressure was 130 / 95 mmHg, blood lipid (triglyceride) was 2.2 mmol / L, and blood glucose was 6.0 mmol / L, and he could participate in various activities normally.

[0036] Case Report: 4. Patient: Liu XX, female, 29 years old. After 6 years of marriage, she was infertile without any reason during menstruation. Usually, she had no other problems. She and her family were anxious. After seeking medical treatment from many places without success, she was recommended to use the paste-like pharmaceutical composition (paste formula) of this application for conditioning. According to traditional Chinese medicine syndrome differentiation, it was kidney essence deficiency and liver blood insufficiency, resulting in dryness of the uterus and inability to capture sperm. The treatment principle was to nourish blood, regulate qi, and nourish yin. After taking the paste-like pharmaceutical composition (paste formula) of this application for conditioning for half a year, she gave birth to a healthy baby boy in May this year.

[0037] The paste-like pharmaceutical composition (the paste-like pharmaceutical composition of this application) prepared in Example 2 above was used for the research of the following efficacy tests.

[0038] Experimental Example 1 Research on the lipid-lowering effect of the paste-like pharmaceutical composition of this application 1. Research on the lipid-lowering effect on mice 70 mice were randomly divided into 7 groups, namely normal control group, high-fat model group, simvastatin (1.25 mg / kg) group, wolfberry liquid group, low-dose (0.25 g / kg) group of the paste-like pharmaceutical composition of this application, medium-dose (0.5 g / kg) group of the paste-like pharmaceutical composition of this application, and high-dose (1.5 g / kg) group of the paste-like pharmaceutical composition of this application, with 10 mice in each group, half male and half female. The model control group and the normal control group were given an equal volume of normal saline, and the other groups were administered by gavage once a day for 10 consecutive days. 2 hours after the last administration, except for the normal control group, the other 5 groups were intraperitoneally injected with 0.1 mL / 10 g of fresh egg yolk emulsion. After 20 hours, the eyeballs were removed and blood was taken. The mice were fasted for 12 hours before blood collection but were allowed to drink water. Serum TC, TG, HDL-C, and LDL-C of the mice were measured.

[0039] Table 1 Effects of the medicine and food dual-purpose composition formula on hyperlipidemia in mice Note: Compared with the normal saline group, △p < 0.05; △△p < 0.01; compared with the model group, *p < 0.05; **p < 0.0 As can be seen from the results in Table 1, through the comparison of the above 7 groups of test data, since no drugs were used in the high-fat model group, the detection values of TC, TG, and LDLC were significantly higher than those of the other 6 groups. Compared with the normal saline group, the P values were less than 0.05 and 0.01 respectively, showing significant differences. Similarly, for the HDLC group, since no drugs were used in the high-fat model group, the HDLC was significantly lower, and the P values were less than 0.05 and 0.01 respectively, showing significant differences. Compared with the simvastatin group, the high-dose wolfberry paste group had the same significant lipid-lowering effect as the simvastatin group, and some indicators were even better than those of the simvastatin group. It proves that the lipid-lowering efficacy of the paste-like pharmaceutical composition of this application is reliable.

[0040] 2. Normobaric hypoxia tolerance experiment of the paste-like pharmaceutical composition of this application on mice Sixty mice were randomly divided into 6 groups, with 10 mice in each group, namely the normal saline control group (NS), wolfberry liquid group, aqueous decoction of dried ginseng group, high-dose (YQD), medium-dose (YQZ), and low-dose (YQX) groups. The mice were continuously gavaged for 10 days. 30 minutes after the last administration (parallel operation), they were placed into 150 mL ground-glass bottles containing 15 g of soda lime (1 mouse per bottle), sealed with a lid, and the bottle mouth was coated with vaseline. Taking the cessation of breathing as the death criterion, the time from sealing the bottle mouth to the cessation of the mouse's breathing was recorded as the survival time, and the percentage increase in hypoxia survival time was calculated as = (hypoxia survival time of the drug-administered group - hypoxia survival time of the normal group) / hypoxia survival time of the normal group × 100 Table 2 Percentage increase in survival time Note: Compared with the normal saline group, *p < 0.05; **p < 0.01 As can be seen from the results in Table 2, for the normobaric hypoxia tolerance experiment of the paste-like pharmaceutical composition of this application on mice: Through the above experiment, after continuously gavaging the mice formulated with this product in different dosage forms and the control group mice for 10 days respectively, the mice were separately placed into ground-glass bottles containing soda lime, sealed with lids, and carefully observed and recorded. The survival time of the high-dose group of the paste-like pharmaceutical composition of this application in a highly hypoxic environment was the longest, over 34 minutes, and the percentage increase in survival time was 37%, proving its good anti-hypoxia efficacy and being worthy of promotion.

[0041] 3. Report on the weight-bearing swimming experiment of the paste-like pharmaceutical composition of this application on mice 60 mice were randomly divided into 6 groups, 10 mice in each group, including normal saline control group (NS), raw sun-dried ginseng decoction group, oral high (YQD), medium (YQZ), and low (YQX) dose groups. The mice were gavaged for 10 consecutive days. 60 minutes after the last administration (parallel operation), the swimming test was then performed. The mice were loaded with a weight of 1 g on their tails and swam in a 60 cm diameter bucket (the water depth was controlled at 25 cm and the water temperature was 25-27 ℃) until they died of exhaustion.

[0042] Table 3 As can be seen from the results in Table 3, through the weighted swimming experiment on mice using the paste pharmaceutical composition of the present application, the mice were randomly divided into groups and given different dosage forms for continuous gavage for 10 days. The mice were then loaded with a weight of 1 g on their tails and placed in a 60 cm × 25 cm bucket with the water temperature controlled at 25°C-27°C. The mice were allowed to swim until they died of exhaustion. The weighted swimming survival time of the mice was still the longest in the high-dose group of the paste pharmaceutical composition of the present application, with a swimming time of more than 72 minutes and an extension rate of 176.2%. It has excellent endurance effects and can be promoted for application.

[0043] Example 2 Observation of the clinical efficacy of the ointment pharmaceutical composition of the present application in treating type 2 diabetes The clinical efficacy of the ointment pharmaceutical composition of the present application combined with western medicine in treating type 2 diabetes was observed. Patients with diabetes were randomly divided into a treatment group of 180 cases and a control group of 175 cases. Both groups were treated with sulfonylureas, metformin, α-glucose The patients were treated with conventional glucosidase inhibitor for 4 weeks, and the treatment group was additionally treated with the ointment pharmaceutical composition of the present application, while the control group maintained the original basic treatment. The treatment course for both groups was 8 weeks. 1. All cases were from the Department of Endocrinology of Zhongning County Traditional Chinese Medicine Hospital. 355 patients with type 2 diabetes who met the inclusion criteria were collected and randomly divided into two groups. The treatment group had 180 cases, including 82 males and 98 females; the age ranged from 38 to 74 years old, with an average age of (56.4±76) years old; the course of disease ranged from 4 months to 20 years, with an average of 7.2 years; among them, 68 cases had hypertension, 60 cases had dyslipidemia, and 64 cases had coronary heart disease. The control group had 175 cases, including 90 males and 85 females; the age ranged from 36 to 75 years old, with an average age of (56.7±74) years old; the course of disease ranged from 5 months to 21 years, with an average of 7.1 years; among them, 76 cases had hypertension, 55 cases had dyslipidemia, and 58 cases had coronary heart disease. All cases were excluded from patients with liver and kidney dysfunction, type 1 diabetes, tumors, hematopoietic system diseases, mental illness, acute myocardial infarction, severe arrhythmia, acute heart failure, or chronic heart failure of grade 2 or above.

[0044] 2. Diagnostic criteria The Western medicine diagnostic criteria refer to the "WHO Diagnostic Criteria for Diabetes Mellitus in 1999" and the new diagnostic criteria in the "Chinese Guidelines for the Prevention and Treatment of Diabetes Mellitus (2007 Edition)" (Chinese Diabetes Society, 2007). (1) For those with diabetes symptoms (typical symptoms include polydipsia, polyuria, and unexplained weight loss, etc.), diabetes can be diagnosed if one of the following criteria is met: ① Plasma glucose at any time ≥ 11.1 mmol / L (200 mg / dl); ② Fasting (fasting time greater than 8 hours) plasma glucose ≥ 7.0 mmol / L (126 mg / dl); ③ Plasma glucose 2 hours after 75 g glucose load ≥ 11.1 mmol / L (200 mg / dl). (2) For those without diabetes symptoms, two of the above three criteria need to be met.

[0045] 2.2 TCM diagnostic and dialectical criteria are formulated with reference to the "Integrated Traditional Chinese and Western Medicine Diagnosis and Treatment Plan for Type 2 Diabetes Mellitus" in 2009. (1) Qi and Yin deficiency syndrome: Main symptoms: Dry throat and mouth, fatigue. Secondary symptoms: Polyphagia and easy hunger, thirst with preference for drinking, shortness of breath and reluctance to speak, five centers fever, palpitations and insomnia, frequent urination or red urine, constipation or loose stools, red tongue with little fluid and little coating, or pale tongue with thin white coating, thready, rapid and weak pulse. It can be diagnosed when 2 main symptoms are present simultaneously or 1 main symptom + 1 - 2 secondary symptoms are present. (2) Liver and kidney yin deficiency syndrome: Main symptoms: Dry throat and mouth, soreness and weakness of the waist and knees, blurred vision. Secondary symptoms: Yellowish and scanty urine or frequent urination, dry stools, dizziness and tinnitus, five centers fever, excessive thirst with preference for drinking, red tongue with little coating and thready, rapid pulse. It can be diagnosed when 3 main symptoms are present simultaneously or 2 main symptoms + 2 secondary symptoms are present.

[0046] 2.3 Inclusion criteria for cases All type 2 diabetes patients aged 36 - 75 years who meet the Western medicine diagnostic criteria and two TCM dialectical types.

[0047] 3. Treatment methods Both groups were given conventional treatment with sulfonylureas, metformin, and α - glucosidase inhibitors for 4 weeks on the basis of diet control. The treatment group was additionally given the paste - like pharmaceutical composition of the present application (a paste - like viscous liquid developed by the Chinese Medicine Hospital of Zhongning County's Lycium barbarum research room), 10 ml each time, taken directly or diluted with 100 - 200 ml of boiled water and mixed evenly, and taken on an empty stomach in the morning once a day. The control group maintained the original basic treatment. The treatment course for both groups was 8 weeks.

[0048] 4. Observation indicators 4.1 Safety indicators Blood, urine, stool routine, heart, liver, and kidney functions. Check and record once on the 1st day of inclusion, and then re - check once a month. Record the improvement of symptoms and drug toxic and side effects, hypoglycemic reactions during the treatment process.

[0049] 4.2 Fasting blood glucose (FBG) One course of treatment is 2 months. Measure fasting blood glucose once before and after treatment. Blood glucose measurement is performed by the same machine (Hitachi 7020 automatic biochemical analyzer) and the same operator.

[0050] 5. Efficacy criteria: The fasting blood glucose value ≤ 6.5 mmol / L is used as the judgment value. Marked effect: Clinical symptoms disappear and laboratory tests are normal on multiple occasions; Effective: Clinical symptoms are significantly improved, and fasting blood glucose and other tests are improved before and after treatment; Ineffective: Although symptoms are improved, laboratory tests show no obvious improvement.

[0051] 6. Statistical method: Data entry is performed using the Epidata database (double data entry by two people and secondary verification), and statistical processing of the data is carried out using SPSS 11.5 software. The measured data are expressed as mean ± standard deviation. For measurement data, t-tests are used. Paired t-tests are used for comparison before and after treatment. P < 0.05 indicates a statistically significant difference.

[0052] 7. Comparison of the curative effects of the two groups: As can be seen from Table 4, the total effective rate of the treatment group is 86.25%, and the total effective rate of the control group is 76.00%. The difference between the two is significant (P < 0.05), indicating that the curative effect of the paste-like pharmaceutical composition of this application combined with western medicine is better than that of the western medicine treatment group alone. Table 4 Comparison of the clinical curative effects of the two groups of patients [n (%)] Group Number of cases Marked effect (%) Effective (%) Ineffective (%) Total effective rate (%) Treatment group 180 43（23.86） 108（60） 29（16.11） <![CDATA[151 (86.25) * > Control group 175 21（12.00） 112（64.00） 42（24.00） 133（76.00） Note: Compared with the control group, * P < 0.05 As can be seen from Table 5, during the treatment observation period, there was no statistically significant difference in the comparison of FBG before treatment between the two groups (P > 0.05). There was a statistically significant difference in the comparison before and after treatment in the paste-like pharmaceutical composition combined with western medicine treatment group of this application (P < 0.05), and there was no statistically significant difference in the comparison before and after treatment in the control group (P > 0.05). There was a statistically significant difference in the comparison before and after treatment between the two groups (P < 0.05), indicating that the blood glucose lowering effect of the paste-like pharmaceutical composition combined with western medicine treatment group of this application is better than that of the western medicine treatment group alone.

[0053] Table 5 Comparison of FBG before and after treatment in the two groups of patients (X ± S) Group Number of cases FBG before treatment (mmol / L) FBG after treatment (mmol / L) Treatment group 180 7.95±0.51 <![CDATA[6.75±0.51 #* > Control group 175 7.91±0.49 7.91±1.29 Note: Comparison before treatment, * P < 0.05. Compared with the control group, # P < 0.05 Safety evaluation: There were no obvious changes in the three major routine tests and heart, liver, and kidney functions in the two groups, indicating that the paste-like pharmaceutical composition of this application shows no obvious toxic and severe effects and adverse reactions, and has good safety.

[0054] Experimental example 3 Clinical curative effect observation of the paste-like pharmaceutical composition of this application in the treatment of hyperlipidemia Observe the clinical efficacy of the paste pharmaceutical composition of this application in the treatment of hyperlipidemia. 1256 patients who met the diagnostic criteria for dyslipidemia were randomly divided into the treatment group with the paste pharmaceutical composition of this application and the control group, with 628 cases in each group. Both groups took 2 months as one course of treatment, and the efficacy was observed after 2 courses of treatment. Observe the changes in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) in the two groups of patients before and after treatment.

[0055] 1 Data and Methods 1.1 General Information All 1256 cases were patients with hyperlipidemia in the internal medicine outpatient department and inpatient department of Zhongning County Traditional Chinese Medicine Hospital from February 2020 to January 2024, including 700 males and 556 females, aged 35 to 76 years, with a disease course of 6 months to 5 years.

[0056] 1.2 Drugs The paste pharmaceutical composition of this application is composed of Chinese herbal medicines such as Zhongning wolfberry, ginseng, pilose antler, longevity grass, Tianjing grass, cortex lycii radicis, wolfberry fruit stalk, polygonatum sibiricum, and epimedium, provided by the wolfberry research room of Zhongning County Traditional Chinese Medicine Hospital.

[0057] 1.3 Case Selection 1.3.1 Diagnostic Criteria (1) According to the "Guiding Principles for Clinical Research of New Chinese Medicines" [1] Under normal diet conditions, the blood lipid levels after fasting for 12 - 14 hours were detected. When judging whether there is hyperlipidemia, it is necessary to have at least 2 specimen detection records within 1 - 2 weeks. TC ≥ 5.72 mmol / L, or TG ≥ 1.70 mmol / L, with or without HDL-C ≤ 0.91 mmol / L, or in patients with original hyperlipidemia, although they took lipid-lowering drugs, they had stopped taking them for more than 2 weeks, and the blood lipids still met the above criteria. (2) TCM Diagnosis and Differentiation Criteria TCM differentiation is mainly yang qi deficiency and excessive phlegm dampness. The symptoms are mainly manifested as: heavy body, fatigue, abdominal distension, heavy head and chest tightness, even soreness of the waist and knees, shortness of breath when moving, drowsiness, cold limbs, palpitations, shortness of breath, listlessness, spontaneous sweating, purple and dull tongue or with stasis points, white and greasy tongue coating, and stringy, thin and unsmooth pulse.

[0058] 1.3.2 Case Inclusion Criteria All those who met the above hyperlipidemia diagnostic criteria could be included in this observation. Exclusion Criteria for Cases: Liver and kidney function impairment, interruption of treatment before the specified observation period, inability to judge the efficacy, or incomplete data. The selected patients were randomly divided into the treatment group with the paste pharmaceutical composition of this application and the basic treatment control group.

[0059] 1.4 Treatment method: While the control group carried out basic treatments such as health education and diet adjustment for the patients, 20 mg of simvastatin pills were given once every night. While the treatment group carried out basic treatments, the paste-like pharmaceutical composition of the present application was additionally used. Dosage: 10 ml once, added with 100 - 200 ml of boiled water, diluted and taken on an empty stomach once a day for 1 month continuously. The two groups took 2 months as one course of treatment, and all cases were observed for one course of treatment. During the observation period, blood lipids were rechecked once every 2 months.

[0060] 1.5 Efficacy evaluation criteria: In accordance with the "Guiding Principles for Clinical Research of New Chinese Medicines". ① Clinical control: All laboratory tests returned to normal; ② Marked effect: Any of the following was achieved in blood lipid detection: TC decreased by ≥ 20%, TG ≥ 40%, HDL increased by ≥ 0.26 mmol / L; ③ Effective: Any of the following was achieved in blood lipid detection: TC decreased by ≥ 10% but < 20%, TG decreased by ≥ 20% but < 40%, HDL-C increased by ≥ 0.104 mmol / L but < 0.26 mmol / L; ④ Ineffective: Those that did not meet the above criteria in blood lipid detection.

[0061] 1.6 Observation indicators: Efficacy indicators of blood lipids include total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C), which were detected by an automatic biochemical analyzer. Safety indicators include routine blood, urine, and stool tests, as well as heart, liver, and kidney functions, etc.

[0062] 1.7 Statistical analysis: Analyzed using SPSS 18.0 statistical software, and the results were expressed as mean ± standard deviation (x ± s). Independent sample t-tests were used for between-group comparisons, and P < 0.05 was considered statistically significant.

[0063] Table 6 Comparison of clinical efficacy between the two groups of patients [n (%)] Group Number of cases Marked effect (%) Effective (%) Ineffective (%) Total effective rate (%) Treatment group 628 220（35.03） 324（51.59） 84（13.37） <![CDATA[544 (86.62) * > Control group 628 199（31.69） 293（46.66） 136（21.66） 492（78.34） Note: Compared with the control group, * P < 0.05 Table 7 Changes in blood lipids of the two groups of patients before and after treatment (mmol / L, x ± s) Group Number of cases Time TC TG LDL-C HDL-C Treatment group 628 Before treatment 5.95±0.71 2.31±0.45 4.35±1.11 1.20±0.31 After treatment <![CDATA[5.07±1.41 #* > <![CDATA[1.68±0.40 # > <![CDATA[3.50±1.07 #* > <![CDATA[1.69±0.30 #* > Control group 628 Before treatment 5.93±0.74 2.31±0.54 4.45±1.91 1.09±0.31 After treatment 5.61±1.39 2.13±0.41 4.28±2.10 1.11±0.43 Note: Compared before treatment, * P < 0.05; compared with the control group, # P < 0.05 As can be seen from the results of Table 6 and Table 7, after 2 treatment courses, the total effective rate of the treatment group was 86.67%, and that of the control group was 78.33%. There was a statistically significant difference in the therapeutic effects between the two groups (P<0.05); there was a statistically significant difference in TC, TG, HDL-C, and LDL-C between the treatment group and the control group (P<0.05). The "Zhongning paste-like pharmaceutical composition" has good clinical effects in the treatment of hyperlipidemia with yang deficiency and excessive phlegm-dampness, and has high safety.

[0064] Safety evaluation: There were no obvious changes in the three major routine tests and the heart, liver, and kidney functions of the two groups, indicating that the paste-like pharmaceutical composition of this application had no obvious toxic and side effects or adverse reactions, and had good safety.

[0065] Example 4 Clinical efficacy observation of the paste-like pharmaceutical composition of this application in the treatment of hypertension To observe the clinical effects of the paste-like pharmaceutical composition of this application combined with western medicine in the treatment of hypertension. 256 patients with hypertension were randomly divided into a treatment group of 150 cases and a control group of 106 cases. Both groups were treated with conventional western medicine antihypertensive drugs. On this basis, the treatment group was additionally treated with the paste-like pharmaceutical composition of this application, and the control group maintained the original basic treatment unchanged. The treatment course of both groups was three months. Blood pressure was measured on time before and after treatment, and the blood pressure changes of the two groups were observed.

[0066] Data and methods: 1. General information: 256 patients with hypertension were all outpatients with hypertension and inpatients with hypertension in the Department of Cardiology of Zhongning County Traditional Chinese Medicine Hospital from February 2020 to January 2024. There were 150 cases in the treatment group (80 males and 70 females), and 106 cases in the control group (56 males and 50 females), aged 45 to 80 years, with a disease course of 6 months to 10 years.

[0067] 2. Medicine: The paste-like pharmaceutical composition of this application was provided by the Wolfberry Research Office of Zhongning County Traditional Chinese Medicine Hospital.

[0068] 3. Case selection: Measure blood pressure correctly. Since blood pressure is volatile and can cause a temporary increase in blood pressure during emotional excitement and physical activity, it should be diagnosed as hypertension only when blood pressure is measured at least twice in a non-simultaneous resting state, and the blood pressure value should be calculated as the average of three consecutive measurements. Careful examination helps to detect secondary hypertension and organ damage.

[0069] Diagnose hypertension based on the patient's medical history and the results of various examinations. At present, the diagnosis of hypertension in China adopts the standard recommended by the 2005 Chinese Hypertension Treatment Guidelines: above 140-159 / 90-99 mmHg. If the patient's systolic blood pressure and diastolic blood pressure belong to different levels respectively, the higher grading standard shall prevail.

[0070] Case inclusion criteria: All those who meet the diagnostic criteria for hypertension can be included, but those with liver and kidney function impairment, those with undiagnosed hypertension, those who cannot judge the treatment criteria, or those with incomplete data should be excluded. The 256 selected hypertensive patients were randomly divided into the paste pharmaceutical composition combined with basic treatment group and the control basic treatment group of this application.

[0071] Treatment method: In the control group, while carrying out basic treatments such as health education and diet adjustment for patients, amlodipine or nifedipine was given for treatment, taken once every night. In the treatment group, on the basis of this basic treatment, the paste pharmaceutical composition of this application was added. Dosage: 10 ml each time, twice a day. Dilute it with 100 ml of boiled water and drink it on an empty stomach in the morning and evening. Both groups took 3 months as 1 course of treatment, and all cases were observed for three months. During the observation period, the blood pressure was rechecked at the required time (there was no statistical significance in terms of age, gender, disease course, etc. between the two groups (P>0.05)).

[0072] Statistical processing: Analyzed using SPSS 18.0 statistical software, and the results were expressed as mean ± standard deviation ( ). Independent sample t-tests were used for between-group comparisons, and P<0.05 was considered statistically significant.

[0073] Table 8 Comparison of clinical efficacy between two groups of hypertensive patients (%) Group Number of cases Marked effect (%) Effective (%) Ineffective (%) Total effective rate (%) Treatment group 150 60（40%） 72（48%） 18（12%） 132（88%） Control group 106 41（38.68%） 50（47.17%） 15（14.15%） 91（85.85%） Note: Compared with the control group, P<0.05, indicating statistical significance From the results in Table 8, it can be seen that the total effective rate of the treatment group was (88%), and the total effective rate of the control group was (85.85%). There was a statistically significant difference in the total clinical treatment efficiency between the two groups (P<0.05). The paste pharmaceutical composition of this application can also improve other clinical discomfort symptoms of patients while reducing blood pressure.

[0074] Specific implementation case method 1 Hypertensive patient: Yong Moumou, gender: male, age: 70 years old, lives in Yuding Township, Zhongning County. Past medical history: Hypertension with cerebral infarction for 2 years. Time of taking the paste: From April 15, 2024 to July 15, 2024, for three months. Method of taking the paste: Each time, take 10 ml of the paste pharmaceutical composition of this application (the paste pharmaceutical composition of this application was developed by the Lycium Research Office of Zhongning County Traditional Chinese Medicine Hospital), add 100 ml of boiled water, stir well and drink, twice a day.

[0075] Comparison of the main clinical manifestations and laboratory tests during the period when the patient took the paste: Main clinical manifestations before taking the paste: Dizziness, vertigo, poor sleep, mild abnormal movement of the left limb, red, dark purple tongue, stringy and thready pulse, dry stools, frequent urination. Blood pressure 165 / 105 mmHg, heart rate 90 beats / min, both lungs (-), muscle strength of the left lower limb 4 levels.

[0076] Laboratory tests: Liver and kidney functions, and electrolytes are all normal. Blood glucose is 6.5 mmol / L, triglyceride is 2.84 mmol / L, total cholesterol is 6.4 mmol / L, high-density lipoprotein is 1.18 mmol / L, and low-density lipoprotein is 3.5 mmol / L.

[0077] After taking the paste pharmaceutical composition of the present application for 45 days, physical examination shows: The main clinical manifestations are that dizziness, vertigo and sleep have improved compared with before. The tongue is red, the pulse is stringy and thready, the stool is normal, and the urine is normal. During the period of taking the paste, the measured blood pressure fluctuates around 140 - 150 / 90 - 95 mmHg. Both lungs are (-).

[0078] Laboratory tests: Liver and kidney functions, and electrolytes are normal. Blood glucose is 5.6 mmol / L, triglyceride is 2.20 mmol / L, total cholesterol is 5.3 mmol / L, high-density lipoprotein is 1.29 mmol / L, and low-density lipoprotein is 3.01 mmol / L.

[0079] After taking the paste pharmaceutical composition of the present application for 90 days, physical examination shows: The main clinical manifestations are that dizziness, vertigo and sleep have improved significantly. The tongue is rosy, the pulse is stringy, the stool and urine are normal. Blood pressure is 135 / 95 mmHg, electrolytes are normal, blood glucose is 4.9 mmol / L, triglyceride is 1.72 mmol / L, total cholesterol is 4.8 mmol / L, high-density lipoprotein is 1.45 mmol / L, and low-density lipoprotein is 2.37 mmol / L. Summary: After taking the paste pharmaceutical composition of the present application for 3 months, the dizziness, vertigo and sleep of the patient Yong Lixin have improved significantly. At the same time, the blood pressure is well controlled, the blood lipid has decreased significantly, and there are no side effects such as liver and kidney function damage or getting angry after taking the medicine.

[0080] Observation indicators: The main goal of hypertension treatment is to achieve blood pressure standard. The ultimate goal of antihypertensive treatment is to minimize the incidence and mortality of cardiovascular and cerebrovascular diseases in hypertensive patients. The control target value should be established for antihypertensive treatment. On the other hand, hypertension often coexists with other risk factors of cardiovascular and cerebrovascular diseases, and all treatment measures should be considered and should be comprehensive. The antihypertensive targets are different for different populations. The antihypertensive target for general hypertensive patients is below 140 / 90 mmHg. For high-risk patients with diabetes or gastric diseases, etc., it should be reduced to a lower level as appropriate (pay special attention to the monitoring of early morning blood pressure).

[0081] Specific implementation case mode 2 Patient Li with hypertension, female, 70 years old, from Dazhanchang Township, Zhongning County. Past medical history: chronic gastritis for 8 years, intermittently taking omeprazole capsules and domperidone tablets, occasionally having discomfort in the stomach; hypertension for 10 years, taking nifedipine sustained-release tablets 10 mg each time, twice a day and enalapril 10 mg each time, once a day. Usually, the blood pressure is maintained at 140 - 160 / 90 - 100 mmHg. It was previously found that the blood lipid was high and not treated, and the diet was appropriately controlled.

[0082] The time when the patient took the paste: from May 18, 2024 to August 17, 2024, a total of 3 months.

[0083] The method for the patient to take the paste: The patient takes 20 ml of the paste-like pharmaceutical composition of the present application each time, dilutes it with 100 ml of boiling water and then drinks it. It is taken twice a day, in the morning and evening.

[0084] During the period when the patient took the paste-like pharmaceutical composition of the present application, the original antihypertensive drugs were continued to be taken, and the blood pressure was regularly monitored.

[0085] Health guidance during the period of taking the paste-like pharmaceutical composition of the present application: Low-salt, low-fat, and low-sugar diet, avoid eating raw, cold, and stimulating foods, keep a happy mood, do appropriate exercise, and avoid getting cold.

[0086] The main clinical manifestations of the patient before taking the paste-like pharmaceutical composition of the present application: dizziness, vertigo, tinnitus, poor sleep, dry stools, frequent nocturia, red tongue, and thready and taut pulse. Physical examination: blood pressure 150 / 95 mmHg, heart rate 80 beats per minute, both lungs (-). Before taking the paste-like pharmaceutical composition of the present application, the liver and kidney functions were normal, blood glucose 6.1 mmol / L, triglyceride 2.8 mmol / L, total cholesterol 6.8 mmol / L, high-density lipoprotein 1.23 mmol / L, and low-density lipoprotein 4.53 mmol / L.

[0087] The main clinical manifestations of the patient three months after taking the paste-like pharmaceutical composition of the present application: dizziness and vertigo improved compared with before, tinnitus disappeared, nocturnal sleep improved, defecation and urination were normal, the tongue was rosy, and the pulse was taut. During the period of taking the paste, the measured blood pressure fluctuated around 120 - 130 / 80 - 90 mmHg. After taking it for three months, the liver function was normal upon reexamination, blood glucose 6.0 mmol / L, triglyceride 2.10 mmol / L, total cholesterol 5.0 mmol / L, high-density lipoprotein 1.51 mmol / L, and low-density lipoprotein 3.31 mmol / L.

[0088] Comparing before and after patient Li took the paste-like pharmaceutical composition of the present application, dizziness, vertigo, tinnitus, and nocturnal sleep improved significantly. At the same time, the blood pressure was well controlled, the blood lipid decreased significantly, and there were no side effects such as liver and kidney function damage or getting angry after taking it.

[0089] In this article, specific examples are used to elaborate on the principles and implementation modes of the present invention. The description of the above embodiments is only used to help understand the method and its core idea of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principles of the present invention, several improvements and optimizations can still be made to the present invention, and these improvements and optimizations also fall within the protection scope of the claims of the present invention.

Claims

1. A medicinal and edible composition, characterized in that: The composition comprises the following raw materials in parts by weight: 100-400 parts of Zhongning wolfberry, 10-50 parts of ginseng, 10-50 parts of velvet antler, 20-80 parts of polygonatum, 20-80 parts of dendrobium, 10-50 parts of lycium bark, 0.5-2 parts of sedum sempervivum, 2-6 parts of tianjingcao, 2-6 parts of wolfberry fruit stalks, and 10-50 parts of epimedium.

2. A medicinal and edible composition, characterized in that: The composition comprises the following raw materials in parts by weight: 250 parts of Zhongning wolfberry, 25 parts of ginseng, 25 parts of pilose antler, 50 parts of polygonatum, 50 parts of dendrobium, 25 parts of lycium bark, 1 part of longevity grass, 4 parts of tianjingcao, 4 parts of wolfberry fruit stalks, and 25 parts of epimedium.

3. Use of the medicine-food combination according to claim 1 or 2 in the preparation of hypoglycemic drugs.

4. Use of the medicine-food combination according to claim 1 or 2 in the preparation of a lipid-lowering drug.

5. Use of the medicine-food composition according to claim 1 or 2 in the preparation of blood pressure lowering drugs.

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