Tibetan medicine zotai and processing method thereof

Abstract

The invention discloses a Tibetan medicine zogtai and a processing method thereof, and relates to the technical field of Tibetan medicine zogtai processing, the Tibetan medicine zogtai comprises the following raw materials by weight: 9%-11% of pearl powder, 14%-16% of safflower, 4%-6% of saffron crocus, 4%-6% of bear gall powder, 9%-11% of pomegranate seed, 9%-11% of meconopsis and 43%-59% of other traditional zogtai components. The components are carefully selected and proportioned, so that the synergistic interaction of a plurality of pharmacological actions is realized. According to the formula, the medicine effect of a traditional Zhitai component is reserved, the treatment effect of the traditional Zhitai component is further improved by adding saffron crocus, meconopsis and other effective components confirmed by modern pharmacological research, the prepared Zhitai product keeps the curative effect of a traditional Tibetan medicine, meanwhile, the mercury intake is reduced, and the medication safety is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of the processing of Tibetan medicine Zuotai, and particularly relates to a Tibetan medicine Zuotai and its processing method. Background Art

[0002] The processing techniques of Tibetan medicine are the historical achievements and essence of Tibetan medicine. It has its own system, unique features, profound cultural heritage and scientific connotations, and occupies an important position in the field of world traditional medicine. Especially the processing of mineral medicine represented by Zuotai is the most miraculous, which can be regarded as the core technology of Tibetan medicine processing. It has a history of more than 800 years and has been included in the first batch of national intangible cultural heritage lists.

[0003] Zuotai is a transliteration of Tibetan. "Zuo" means boiling and "Tai" means ash or charcoal, and together it means mercury refined into ash. During the processing of mercury, more than 100 kinds of raw and auxiliary drugs such as "eight metals" and "eight minerals" are added. After more than 300 complex processing procedures such as decontamination, detoxification, boiling, and refining, and the processing time is up to more than 30 days, the toxicity of mercury is removed and the nature of mercury is changed. Finally, the black powder-like Tibetan medicine Zuotai is made, which has the effects of detoxifying, nourishing, and prolonging life. It is commonly used in classic prescriptions for toxicosis, gastrointestinal diseases, yellow water disease, intractable diseases, health care, etc. It is also an essential ingredient in precious Tibetan medicine prescriptions such as seventy-flavor pearl pill, Renqing Changjue, Renqing Mangjue, and Zuozhu Daxi. Combined with other formulas, it has the effect of doubling the curative effect.

[0004] However, since mercury is added and complex processing techniques are adopted in the production process of Tibetan medicine Zuotai, patients need to pay attention to the mercury intake when using Zuotai to avoid overuse. Although most of the toxicity has been removed after careful processing of Zuotai, it still needs to be used with caution to ensure the safety of medication. For this reason, we propose a Tibetan medicine Zuotai and its processing method. Summary of the Invention

[0005] The purpose of the present invention is to solve the problem that since mercury is added and complex processing techniques are adopted in the production process of Tibetan medicine Zuotai, patients need to pay attention to the mercury intake when using Zuotai to avoid overuse. Although most of the toxicity has been removed after careful processing of Zuotai, it still needs to be used with caution to ensure the safety of medication. The present invention provides a Tibetan medicine Zuotai and its processing method.

[0006] The present invention specifically adopts the following technical solutions to achieve the above purpose:

[0007] A Tibetan medicine Zuotai, the Tibetan medicine Zuotai comprises the following raw materials in weight ratio: pearl powder 9%-11%, safflower 14%-16%, crocus 4%-6%, bear bile powder 4%-6%, pomegranate seeds 9%-11%, meconopsis 9%-11%, other traditional Zuotai components: 43%-59%.

[0008] Furthermore, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: pearl powder 9.5%, safflower 15.5%, crocus sativus 5.5%, bear bile powder 4.5%, pomegranate seeds 10%, meconopsis 10%, and other traditional Zuotai components 45%.

[0009] Furthermore, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: pearl powder 10.5%, safflower 14.5%, crocus sativus 5%, bear bile powder 5%, pomegranate seeds 11%, meconopsis 10%, and other traditional Zuotai components 44%.

[0010] Furthermore, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: pearl powder 11%, safflower 14%, crocus sativus 4%, bear bile powder 6%, pomegranate seeds 9%, meconopsis 11%, and other traditional Zuotai components 45%.

[0011] Furthermore, the other traditional Zuotai components include detoxified mercury, nacre, safflower, clove, nutmeg, cinnamon, frankincense, myrrh, pomegranate seeds, tsaoko, costus root, agarwood, bear bile, bezoar, and musk.

[0012] A method for processing Tibetan medicine Zuotai comprises the following steps:

[0013] S1. Weigh the raw materials, and weigh the raw material powders according to the formula of pearl powder 9% - 11%, safflower 14% - 16%, crocus sativus 4% - 6%, bear bile powder 4% - 6%, pomegranate seeds 9% - 11%, meconopsis 9% - 11%, and other traditional Zuotai components: 43% - 59%.

[0014] S2. Mix the raw materials, use a high-precision mixer with the rotation speed controlled at 100 - 200 RPM and the mixing time of 15 minutes to uniformly mix all the powdery raw materials.

[0015] S3. Dry the raw materials, use a vacuum dryer with the vacuum degree maintained at -0.09 MPa, the temperature controlled at 40 - 50 °C, and the drying time of 3 hours to dry the mixed powder to remove moisture.

[0016] S4. Homogenize and disperse, use a high-pressure homogenizer with the pressure set at 100 - 200 MPa and the circulation times of 5 times to uniformly disperse the components that are difficult to mix, such as bear bile powder.

[0017] S5. Nano-processing, use a ball mill with the ball-to-material ratio of 5:1 and the grinding time of 24 hours to further refine the mixture to the nano level to improve the bioavailability.

[0018] S6. Plasma treatment, use atmospheric pressure plasma with the treatment time of 5 minutes for surface modification to improve the stability and solubility of Zuotai.

[0019] Further, after the processing of the Tibetan medicine Zuotai is completed, HPLC and GC-MS are used to analyze the components of the processed Zuotai to ensure the component ratio and purity.

[0020] The beneficial effects of the present invention are as follows:

[0021] 1. By carefully selecting and proportioning the above components, the present invention achieves the synergistic effect of multiple pharmacological effects. This formula not only retains the efficacy of traditional Zuotai components but also further enhances its therapeutic effect by adding effective components such as saffron and meconopsis verified by modern pharmacological research. In addition, through precise control of key steps such as mixing, drying, homogeneous dispersion, nanometer processing, and plasma treatment, the component stability and bioavailability of Zuotai are ensured. Finally, the prepared Zuotai product reduces the mercury intake while maintaining the efficacy of traditional Tibetan medicine, improving the safety of medication.

[0022] 2. The improved formula of the Tibetan medicine Zuotai of the present invention can effectively scavenge free radicals, reduce skin inflammation, and promote the regeneration and repair of skin cells by adding components rich in antioxidants such as saffron and pomegranate seeds, having stronger anti-inflammatory and antioxidant effects. Through the synergistic effect of components such as safflower, saffron, and meconopsis, this formula can accelerate the regeneration of skin cells, promote the repair of damaged skin, make the skin healthier and smoother, having more comprehensive skin repair ability. By adding components such as sulfur, sulfur and other components have strong bactericidal ability, can remove bacteria and fungi on the skin surface, and at the same time remove excess cutin, making the skin more refreshing, smooth, and having stronger bactericidal and keratolytic effects and stronger skin regeneration ability.

[0023] 3. In the processing method used in the present invention, the nanometer technology has been proven to significantly improve the bioavailability and dissolution rate of drugs. The plasma treatment technology has extensive applications in improving the surface activity and stability of materials. Experimental data show that for Zuotai processed by the above processing method, the content and stability of its main components have both increased, and better pharmacological effects are shown in animal experiments. Description of the Drawings

[0024] Figure 1 is the processing flow chart of the Tibetan medicine Zuotai in the present invention. Detailed Embodiments

[0025] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention.

[0026] The present invention provides a Tibetan medicine Zuotai, which comprises raw materials in the following weight ratios: 9%-11% of pearl powder, 14%-16% of safflower, 4%-6% of crocus sativus, 4%-6% of bear bile powder, 9%-11% of pomegranate seeds, 9%-11% of meconopsis, and 43%-59% of other traditional Zuotai components.

[0027] In this embodiment, preferably, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: 9.5% of pearl powder, 15.5% of safflower, 5.5% of crocus sativus, 4.5% of bear bile powder, 10% of pomegranate seeds, 10% of meconopsis, and 45% of other traditional Zuotai components.

[0028] In this embodiment, preferably, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: 10.5% of pearl powder, 14.5% of safflower, 5% of crocus sativus, 5% of bear bile powder, 11% of pomegranate seeds, 10% of meconopsis, and 44% of other traditional Zuotai components.

[0029] In this embodiment, preferably, the Tibetan medicine Zuotai comprises raw materials in the following weight ratios: 11% of pearl powder, 14% of safflower, 4% of crocus sativus, 6% of bear bile powder, 9% of pomegranate seeds, 11% of meconopsis, and 45% of other traditional Zuotai components.

[0030] In this embodiment, preferably, the other traditional Zuotai components include detoxified mercury, mother-of-pearl, safflower, clove, nutmeg, cinnamon, frankincense, myrrh, pomegranate seeds, tsaoko, costus root, agarwood, bear bile, bezoar, and musk.

[0031] Please refer to Figure 1 , the present invention provides a preparation method of Tibetan medicine Zuotai, which comprises the following steps:

[0032] S1. Weigh the raw materials, and weigh the raw material powders according to the formula of 9%-11% of pearl powder, 14%-16% of safflower, 4%-6% of crocus sativus, 4%-6% of bear bile powder, 9%-11% of pomegranate seeds, 9%-11% of meconopsis, and 43%-59% of other traditional Zuotai components;

[0033] S2. Mix the raw materials, use a high-precision mixer with the rotation speed controlled at 100-200 RPM and the mixing time of 15 minutes to uniformly mix all the powdery raw materials;

[0034] S3. Dry the raw materials, use a vacuum dryer with the vacuum degree maintained at -0.09 MPa, the temperature controlled at 40-50 °C, and the drying time of 3 hours to dry the mixed powder to remove moisture;

[0035] S4. Homogenize and disperse, use a high-pressure homogenizer with the pressure set at 100-200 MPa and the circulation times of 5 times to uniformly disperse the components that are difficult to mix, such as bear bile powder;

[0036] S5. Nano - processing: Use a ball mill with a ball - to - material ratio of 5:1 and a grinding time of 24 hours to further refine the mixture to the nanoscale to improve bioavailability.

[0037] S6. Plasma treatment: Use atmospheric pressure plasma with a treatment time of 5 minutes for surface modification to improve the stability and solubility of Zotai.

[0038] The nanotechnology has been proven to significantly improve the bioavailability and dissolution rate of drugs. The plasma treatment technology has a wide range of applications in improving the surface activity and stability of materials. Experimental data show that for Zotai processed by the above - mentioned processing methods, the content and stability of its main components have been improved, and it shows better pharmacodynamic effects in animal experiments.

[0039] In this embodiment, preferably, after the processing of the Tibetan medicine Zotai, HPLC and GC - MS are used to analyze the components of the processed Zotai to ensure the component ratio and purity.

[0040] By carefully selecting and proportioning the above - mentioned components, the present invention realizes the synergistic effect of multiple pharmacological effects. This formula not only retains the pharmacodynamic effects of traditional Zotai components but also further enhances its therapeutic effect by adding effective components such as saffron and meconopsis verified by modern pharmacological research. In addition, through precise control of key steps such as mixing, drying, homogeneous dispersion, nano - processing, and plasma treatment, this processing method ensures the component stability and bioavailability of Zotai. Finally, the processed Zotai product reduces the mercury intake while maintaining the efficacy of traditional Tibetan medicine, improving the safety of medication.

[0041] The improved formula of Tibetan medicine Zotai can effectively scavenge free radicals, reduce skin inflammation, promote the regeneration and repair of skin cells, and has stronger anti - inflammatory and antioxidant effects by adding components rich in antioxidants such as saffron and pomegranate seeds. Through the synergistic effect of components such as safflower, saffron, and meconopsis, this formula can accelerate the regeneration of skin cells, promote the repair of damaged skin, make the skin healthier and smoother, and have more comprehensive skin repair.

[0042] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art, and the general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather will be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A Tibetan medicine Zuotai, characterized in that: The Tibetan medicine Zuotai comprises the following raw materials in weight ratio: pearl powder 9%-11%, safflower 14%-16%, saffron 4%-6%, bear bile powder 4%-6%, pomegranate seeds 9%-11%, meconopsis 9%-11%, and other traditional Zuotai ingredients: 43%-59%.

2. A Tibetan medicine Zuotai according to claim 1, characterized in that: The Tibetan medicine Zuotai comprises the following raw materials in weight ratio: 9.5% pearl powder, 15.5% safflower, 5.5% saffron, 4.5% bear bile powder, 10% pomegranate seeds, 10% meconopsis, and 45% other traditional Zuotai ingredients.

3. The Tibetan medicine Zuotai according to claim 1, characterized in that: The Tibetan medicine Zuotai comprises the following raw materials in weight ratio: 10.5% pearl powder, 14.5% safflower, 5% saffron, 5% bear bile powder, 11% pomegranate seeds, 10% meconopsis, and 44% other traditional Zuotai ingredients.

4. The Tibetan medicine Zuotai according to claim 1, characterized in that: The Tibetan medicine Zuotai comprises the following raw materials in weight ratio: 11% pearl powder, 14% safflower, 4% saffron, 6% bear bile powder, 9% pomegranate seeds, 11% meconopsis, and 45% other traditional Zuotai ingredients.

5. The Tibetan medicine Zuotai according to claim 1, characterized in that: Other traditional zotai ingredients include detoxified mercury, mother of pearl, safflower, cloves, nutmeg, cinnamon, frankincense, myrrh, pomegranate seeds, grass fruit, costus root, agarwood, bear gall, bezoar and ground incense.

6. A method for preparing Tibetan medicine Zuotai, characterized in that: It includes the following steps: S1. Weigh the raw materials and weigh the raw material powder according to the formula of pearl powder 9%-11%, safflower 14%-16%, saffron 4%-6%, bear bile powder 4%-6%, pomegranate seeds 9%-11%, meconopsis 9%-11%, and other traditional zotai ingredients: 43%-59%; S2, mixing raw materials, using a high-precision mixer with a speed controlled at 100-200 RPM, mixing time 15 minutes, uniformly mixing all powdered raw materials; S3, drying the raw materials, using a vacuum dryer to maintain the vacuum degree at -0.09MPa, the temperature controlled at 40-50°C, the drying time for 3 hours, and drying the mixed powder to remove moisture; S4, homogenization and dispersion, using a high-pressure homogenizer with a pressure of 100-200 MPa and 5 cycles to evenly disperse ingredients that are difficult to mix, such as bear bile powder; S5, nano-processing, using a ball mill with a ball-to-material ratio of 5:1 and a grinding time of 24 hours to further refine the mixture to the nanometer level to improve bioavailability; S6. Plasma treatment, using atmospheric pressure plasma for 5 minutes, for surface modification to improve the stability and solubility of ZOTA.

7. The processing method of the Tibetan medicine Zuotai according to claim 6, characterized in that: After the Tibetan medicine Zuotai is processed, HPLC and GC-MS are used to analyze the ingredients of the processed Zuotai to ensure the proportion and purity of the ingredients.

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