Traditional Chinese medicine formula for dissolving artery plaque and preparation method

Abstract

The invention discloses a traditional Chinese medicine formula for dissolving artery plaque and a preparation method, and relates to the technical field of traditional Chinese medicine formulae, the traditional Chinese medicine formula comprises the following components by weight: 20-35 parts of Radix Astragali, 5-10 parts of safflower, 12-25 parts of Chinese angelica, 18-35 parts of ginseng, 6-18 parts of earthworm, and 25-40 parts of leech. According to the traditional Chinese medicine formula for dissolving the arterial plaque and the preparation method, the gingko can reduce serum cholesterol and reduce deposition of lipid on blood vessel walls, the hawthorn can regulate blood fat, reduce total cholesterol, triglyceride and the like and reduce material basis for formation of the arterial plaque, and the lotus leaf can reduce blood fat, contribute to reduction of lipid content in blood and cooperate with other medicines, so that the traditional Chinese medicine formula for dissolving the arterial plaque has a good effect on dissolving the arterial plaque. Plaque forming raw materials are reduced from the source, and the cyperus esculentus reduces lipid cores of artery plaques; safflower and peach kernel can improve blood circulation, reduce blood viscosity, inhibit platelet aggregation and prevent thrombosis.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine formula, and specifically relates to a traditional Chinese medicine formula for dissolving arterial plaques and a preparation method thereof. Background Art

[0002] Arterial plaque refers to a kind of deposit formed on the inner wall of arterial blood vessels, mainly composed of components such as lipids (such as cholesterol), smooth muscle cells, inflammatory cells, fibrous tissue, etc., and is usually related to vascular endothelial cell damage. When the vascular endothelium is damaged by factors such as hypertension, hyperlipidemia, hyperglycemia, smoking, oxidative stress, etc., lipids in the blood, especially low-density lipoprotein cholesterol (LDI-C), are more likely to enter the subendothelial layer of blood vessels and be oxidized and modified. This will attract the aggregation of immune cells such as monocytes, gradually forming fatty streaks. As the disease progresses, smooth muscle cells proliferate and secrete extracellular matrix, ultimately forming arterial plaques.

[0003] The body of Hirudo is flat and cylindrical, with a sucker at the front end and a posterior sucker at the rear end, and has certain medicinal value. Its main components include hirudin, heparin, antithrombin and other bioactive substances. Research has found that certain components in Hirudo have a certain fibrinolytic effect, which can activate plasminogen and convert it into plasmin, thereby dissolving the already formed fibrin thrombus. For this reason, the present invention proposes a traditional Chinese medicine formula containing Hirudo to dissolve arterial plaques. Summary of the Invention

[0004] (I) Technical Problems to be Solved In view of the deficiencies of the prior art, the present invention provides a traditional Chinese medicine formula for dissolving arterial plaques and a preparation method thereof, solving the problems mentioned in the above background art.

[0005] (II) Technical Solutions To achieve the above objectives, the present invention is realized through the following technical solutions: A traditional Chinese medicine formula for dissolving arterial plaques, the traditional Chinese medicine formula includes the following components in parts by weight: Astragalus membranaceus 20 - 35 parts, Carthamus tinctorius 5 - 10 parts, Angelica sinensis 12 - 25 parts, Panax ginseng 18 - 35 parts, Pheretima aspergillum 6 - 18 parts, Hirudo 25 - 40 parts.

[0006] Preferably, the traditional Chinese medicine formula further includes the following components in parts by weight: Gastrodia elata 6 - 15 parts, Ginkgo biloba 8 - 26 parts, Nelumbo nucifera Gaertn. leaf 12 - 25 parts, Crataegus pinnatifida 12 - 32 parts.

[0007] Preferably, the traditional Chinese medicine formula further includes the following components in parts by weight: Prunus persica 10 - 18 parts, Ganoderma lucidum 15 - 25 parts, Taraxacum mongolicum Hand.-Mazz. 6 - 18 parts, Cyperus esculentus L. 10 - 25 parts.

[0008] Preferably, the traditional Chinese medicine formula further comprises the following components in parts by weight: 15-25 parts of kudzu root, 10-16 parts of natto, 8.5-20 parts of saffron crocus, and 12-18 parts of hemp seed.

[0009] Preferably, the traditional Chinese medicine formula specifically comprises the following components in parts by weight: 15 parts of gastrodia elata, 26 parts of ginkgo, 25 parts of lotus leaf, 32 parts of hawthorn, 25 parts of kudzu root, 16 parts of natto, 20 parts of saffron crocus, 18 parts of hemp seed, 35 parts of astragalus membranaceus, 10 parts of carthamus tinctorius, 25 parts of angelica sinensis, 35 parts of ginseng, 18 parts of pheretima aspergillum, 40 parts of whitmania pigra, 18 parts of peach kernel, 25 parts of ganoderma lucidum, 18 parts of dandelion, and 25 parts of cyperus esculentus.

[0010] A preparation method of a traditional Chinese medicine formula for dissolving arterial plaques specifically comprises the following preparation steps: Step 1: Weigh each traditional Chinese medicine, extract whitmania pigra, and successively crush, grind, and sieve the remaining traditional Chinese medicines through a 100-110 mesh sieve; Step 2: Decoct with water: For the first time, add 6-8 times the volume of water of the medicinal materials and decoct for 1-1.5 h, and then filter; for the second time, add 4-6 times the volume of water of the medicinal materials and decoct for 45-60 min, and filter; for the third time, add 4-6 times the volume of water of the medicinal materials and decoct for 45-60 min, and filter; mix the obtained filtrates to obtain the traditional Chinese medicine formula for dissolving arterial plaques.

[0011] (III) Beneficial effects The present invention provides a traditional Chinese medicine formula for dissolving arterial plaques and a preparation method. Compared with the prior art, the following beneficial effects are achieved: In the present invention, ginkgo reduces serum cholesterol and decreases the deposition of lipids on the blood vessel wall. Hawthorn regulates blood lipid levels, reduces total cholesterol, triglycerides, etc., and reduces the material basis for the formation of arterial plaques. Lotus leaf reduces blood lipid levels, helps reduce the lipid content in the blood, and synergizes with other drugs to reduce the raw materials for plaque formation at the source. Cyperus esculentus reduces the lipid core of arterial plaques. Safflower and peach kernel improve blood circulation, reduce blood viscosity, inhibit platelet aggregation, prevent thrombus formation, and avoid the aggravation of the condition caused by the interaction between thrombus and plaque. Angelica sinensis makes the blood flow smoothly, reduces blood stasis, and reduces the risk of plaque formation. Earthworm and leech have strong anticoagulant and thrombolytic effects, dissolve the formed thrombus, improve blood vessel blockage, and synergize with other drugs to better improve the intravascular environment. Gastrodia elata maintains the integrity of vascular endothelium, reduces the invasion of substances such as lipids on the blood vessel wall. Astragalus membranaceus promotes the repair and regeneration of vascular endothelial cells, enhances the barrier function of vascular endothelium, and prevents plaque formation and development. Ginseng regulates the function of vascular endothelial cells, promotes the release of vasodilator substances such as nitric oxide, improves vascular elasticity and blood flow state. Pueraria lobata scavenges free radicals in the body, reduces the damage of oxidative stress reaction to the blood vessel wall, protects vascular endothelial cells, and slows down plaque formation. Ganoderma lucidum reduces inflammatory response, protects blood vessels from oxidative damage, synergizes with other antioxidant drugs, and enhances the antioxidant effect. Taraxacum officinale reduces oxidative damage and maintains vascular health. Natto has thrombolytic effect, promotes fibrinolysis, and prevents thrombus formation after plaque rupture. Crocus sativus improves blood circulation and is helpful for the stability and regression of arterial plaques. Cannabis seed regulates blood lipid levels, lubricates the intestines and relieves constipation, reduces toxin absorption, and improves overall metabolism and vascular health. Detailed implementation mode

[0012] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0013] In the present invention, the specific method for extracting leech is as follows: dry and crush the leech, then add absolute ethanol, soak and extract at a temperature of 60 °C for 50 min, and then filter to obtain the filtrate, which is the leech extract.

[0014] Example 1 A preparation method of a traditional Chinese medicine formula for dissolving arterial plaques specifically includes the following preparation steps: Step 1: Weigh each traditional Chinese medicine: Gastrodia elata 6g, Ginkgo biloba 8g, Lotus leaf 12g, Hawthorn 12g, Kudzu root 15g, Natto 10g, Saffron 8.5g, Hemp seed 12g, Astragalus membranaceus 20g, Carthamus tinctorius 5g, Angelica sinensis 12g, Ginseng 18g, Earthworm 6g, Leech 25g, Peach kernel 10g, Ganoderma lucidum 15g, Dandelion 6g, Cyperus esculentus 10g. Extract the leech, and successively pulverize, grind, and sieve the remaining traditional Chinese medicines through a 100-mesh sieve; Step 2: Decoct with water: For the first time, decoct with 6 times the volume of water of the medicinal materials for 1 hour, and then filter; for the second time, decoct with 4 times the volume of water of the medicinal materials for 45 minutes, filter; for the third time, decoct with 4 times the volume of water of the medicinal materials for 45 minutes, filter; mix the obtained filtrates, which is the traditional Chinese medicine formula for dissolving arterial plaques.

[0015] Example 2 A preparation method of a traditional Chinese medicine formula for dissolving arterial plaques specifically includes the following preparation steps: Step 1: Weigh each traditional Chinese medicine: Gastrodia elata 10g, Ginkgo biloba 17g, Lotus leaf 18g, Hawthorn 22g, Kudzu root 20g, Natto 13g, Saffron 12g, Hemp seed 15g, Astragalus membranaceus 28g, Carthamus tinctorius 8g, Angelica sinensis 16g, Ginseng 23g, Earthworm 12g, Leech 32g, Peach kernel 14g, Ganoderma lucidum 20g, Dandelion 12g, Cyperus esculentus 17g. Extract the leech, and successively pulverize, grind, and sieve the remaining traditional Chinese medicines through a 100-mesh sieve; Step 2: Decoct with water: For the first time, decoct with 6 times the volume of water of the medicinal materials for 1 hour, and then filter; for the second time, decoct with 4 times the volume of water of the medicinal materials for 45 minutes, filter; for the third time, decoct with 4 times the volume of water of the medicinal materials for 45 minutes, filter; mix the obtained filtrates, which is the traditional Chinese medicine formula for dissolving arterial plaques.

[0016] Example 3 A preparation method of a traditional Chinese medicine formula for dissolving arterial plaques specifically includes the following preparation steps: Step 1: Weigh each traditional Chinese medicine: Gastrodia elata 15g, Ginkgo biloba 26g, Lotus leaf 25g, Hawthorn 32g, Kudzu root 25g, Natto 16g, Saffron 20g, Hemp seed 18g, Astragalus membranaceus 35g, Carthamus tinctorius 10g, Angelica sinensis 25g, Ginseng 35g, Earthworm 18g, Leech 40g, Peach kernel 18g, Ganoderma lucidum 25g, Dandelion 18g, Cyperus esculentus 25g. Extract the leech, and successively pulverize, grind, and sieve the remaining traditional Chinese medicines through a 110-mesh sieve; Step 2: Decoct with water: For the first time, decoct with 8 times the volume of water of the medicinal materials for 1.5 hours, and then filter; for the second time, decoct with 6 times the volume of water of the medicinal materials for 60 minutes, filter; for the third time, decoct with 6 times the volume of water of the medicinal materials for 60 minutes, filter; mix the obtained filtrates, which is the traditional Chinese medicine formula for dissolving arterial plaques.

[0017] Example 4 A preparation method of a traditional Chinese medicine formula for dissolving arterial plaques, specifically including the following preparation steps: Step 1: Weigh each traditional Chinese medicine: 12 g of Gastrodia elata, 22 g of Ginkgo biloba, 23 g of lotus leaf, 30 g of Hawthorn fruit, 21 g of Pueraria lobata, 15 g of Natto, 17 g of Saffron, 16 g of Cannabis seed, 32 g of Astragalus membranaceus, 9 g of Carthamus tinctorius, 22 g of Angelica sinensis, 32 g of Panax ginseng, 17 g of Pheretima aspergillum, 36 g of Hirudo nipponica, 17 g of Prunus persica, 22 g of Ganoderma lucidum, 16 g of Taraxacum mongolicum, 23 g of Cyperus esculentus. Extract Hirudo nipponica, and the remaining traditional Chinese medicines are successively crushed, ground, and passed through a 100-mesh sieve; Step 2: Decoct with water: Decoct with 6 times the volume of water of the medicinal materials for 1 h for the first time, and then filter; Decoct with 4 times the volume of water of the medicinal materials for 45 min for the second time, filter; Decoct with 4 times the volume of water of the medicinal materials for 45 min for the third time, filter; Mix the obtained filtrates, which is the traditional Chinese medicine formula for dissolving arterial plaques.

[0018] Comparative Example 1 The difference between this comparative example and Example 1 is that: Hirudo nipponica is not added; the rest remains unchanged.

[0019] Comparative Example 2 The difference between this comparative example and Example 1 is that: in the raw materials, Hirudo nipponica is replaced with sea cucumber of the same mass; the rest remains unchanged.

[0020] Randomly divide the mice into the following 6 groups: Experimental Group 1 (Example 1), Experimental Group 2 (Example 2), Experimental Group 3 (Example 3), Experimental Group 4 (Example 4), Control Group 1 (Comparative Example 1), Control Group 2 (Comparative Example 2), with 10 mice in each group. Calculate the dosage for mice according to the conversion coefficient of the dosage for adults and mice. Dissolve the drug in distilled water and administer it by gavage once a day for 13 weeks. Fast the mice overnight before sampling, sacrifice them the next day, and observe the number of plaques (take the average value) in the mice before and after treatment; the results are shown in Table 1.

[0021] Table 1 As shown in Table 1, after feeding the mice with the traditional Chinese medicine formula prepared in Examples 1 - 4 for a period of time, compared with the mice in Comparative Examples 1 - 2, the total number of plaques and the softened plaques are significantly reduced.

[0022] In Comparative Example 1, Hirudo nipponica is not added. Since Hirudo nipponica contains components such as hirudin, it is a natural anticoagulant, and at the same time, it can also enhance the fluidity of blood, improve the blood flow state in blood vessels, and reduce the formation of arterial plaques.

[0023] In Comparative Example 2, leeches were replaced with sea cucumbers. Although sea cucumbers also have certain nourishing and body function regulating effects, contain various nutrients such as sea cucumber polysaccharides, and have certain potential effects such as anticoagulation and lipid-lowering, their blood-activating and stasis-dispelling power is far less than that of leeches. In terms of dissolving arterial plaques, leeches are more targeted and can more directly play the role of breaking blood stasis to disperse plaques. Sea cucumbers mainly regulate the body as a whole and play a certain auxiliary role in improving vascular endothelial function and regulating blood lipids. For already formed arterial plaques, their direct dissolving and eliminating effects are relatively weak.

[0024] Zhang, male, 29 years old. After taking the medicine for three months, the plaque significantly decreased by 70 - 75%. After taking the medicine for six months, the plaque decreased by 80%. After taking the medicine for one year, only 5 - 7% of the plaque remained.

[0025] Li, male, 31 years old. After taking the medicine for three months, the plaque significantly decreased by about 75 - 80%. After taking the medicine for six months, the plaque decreased by 85%. After taking the medicine for one year, only 3 - 5% of the plaque remained.

[0026] In this application, during the medication period, reduce oil and salt intake. After the plaque completely disappears, the diet should also be low in oil and salt to prevent the recurrence of plaques.

[0027] Meanwhile, the content not described in detail in this specification belongs to the prior art well-known to those skilled in the art.

[0028] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions, and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine formula for dissolving arterial plaque, characterized in that: The traditional Chinese medicine prescription comprises the following components in parts by weight: 20-35 parts of astragalus, 5-10 parts of safflower, 12-25 parts of angelica, 18-35 parts of ginseng, 6-18 parts of earthworm and 25-40 parts of leech.

2. A Chinese medicine formula for dissolving arterial plaque according to claim 1, characterized in that: The traditional Chinese medicine formula also includes the following components in parts by weight: 6-15 parts of gastrodia elata, 8-26 parts of ginkgo biloba, 12-25 parts of lotus leaves and 12-32 parts of hawthorn.

3. A Chinese medicine formula for dissolving arterial plaque according to claim 2, characterized in that: The traditional Chinese medicine formula also comprises the following components in parts by weight: 10-18 parts of peach kernel, 15-25 parts of ganoderma lucidum, 6-18 parts of dandelion and 10-25 parts of cyperus oleifera.

4. A Chinese medicine formula for dissolving arterial plaque according to claim 3, characterized in that: The traditional Chinese medicine prescription further comprises the following components in parts by weight: 15-25 parts of kudzu root, 10-16 parts of natto, 8.5-20 parts of saffron and 12-18 parts of hemp seed.

5. A Chinese medicine formula for dissolving arterial plaque according to claim 4, characterized in that: The Chinese medicine formula specifically includes the following components in parts by weight: 15 parts of Gastrodia elata, 26 parts of Ginkgo biloba, 25 parts of lotus leaf, 32 parts of Hawthorn, 25 parts of Pueraria root, 16 parts of Natto, 20 parts of Saffron, 18 parts of Cannabis seed, 35 parts of Astragalus, 10 parts of Safflower, 25 parts of Angelica sinensis, 35 parts of Ginseng, 18 parts of Pheretima, 40 parts of Leech, 18 parts of Peach kernel, 25 parts of Ganoderma lucidum, 18 parts of Taraxacum herb, and 25 parts of Cyperus oleifera.

6. A method for preparing the Chinese medicine formula for dissolving arterial plaque according to claim 5, characterized in that: The specific preparation steps include: Step 1, weighing each Chinese medicine, extracting leeches, and crushing, grinding, and passing the remaining Chinese medicine through a 100-110 mesh sieve in sequence; Step 2, boiling with water: add 6-8 times the volume of the medicinal material in water for the first time, boil for 1-1.5 hours, and then filter; add 4-6 times the volume of the medicinal material in water for the second time, boil for 45-60 minutes, and filter; add 4-6 times the volume of the medicinal material in water for the third time, boil for 45-60 minutes, and filter; mix the obtained filtrates to obtain the traditional Chinese medicine formula for dissolving arterial plaques.

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