Traditional Chinese medicine composition for treating cold-heat mixed abdominal distension and diarrhea and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating cold-heat mixed abdominal distension and diarrhea and a preparation method thereof, and the traditional Chinese medicine composition is characterized by being prepared from the following raw medicinal materials in parts by weight: 3-6 parts of pogostemon cablin, 3-10 parts of rhizoma zingiberis, 3-12 parts of eucommia ulmoides, 3-10 parts of scutellaria baicalensis, 2-6 parts of coptis chinensis, 10-20 parts of fried semen coicis and 6-10 parts of rhizoma pinelliae preparata. The traditional Chinese medicine composition is prepared from 3-10 parts of pericarpium citri reticulatae, 10-15 parts of poria cocos, 6-10 parts of rhizoma atractylodis macrocephalae stir-fried with bran, 6-10 parts of rhizoma corydalis stir-fried with vinegar, 6-10 parts of radix bupleuri stir-fried with vinegar, 6-10 parts of pericarpium arecae, 6-10 parts of ligusticum wallichii, 6-10 parts of mangnolia officinalis, 6-10 parts of stir-fried hawthorn, 3-6 parts of platycodon grandiflorum and 3-10 parts of honey-fried licorice root. The traditional Chinese medicine composition and the traditional Chinese medicine watered pills prepared from the traditional Chinese medicine composition provided by the invention have the effect of treating cold-heat mixed type abdominal distension and diarrhea.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and more particularly to a traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type and a preparation method thereof. Background Art

[0002] People who have a mixed lifestyle and eating habits of staying up late, drinking cold beer, eating barbecue, etc., are prone to damage the spleen and kidney yang qi, resulting in spleen dysfunction, internal dampness and heat in the middle jiao, obstruction of the middle jiao, poor qi movement, inability of the heart fire to go down and warm the kidney water, and inability of the kidney water to go up to relieve the heart fire, resulting in upper heat, lower cold, and dampness and heat in the middle jiao. The patient's syndrome is spleen and kidney yang deficiency, with excessive phlegm and dampness as the root, dampness and heat in the middle jiao as the symptom, and mixed cold and heat. It manifests as hot palms, preference for cold drinks, abdominal distension after eating, occasional noisy stomach, acid regurgitation, sticky and unformed stools, increased bowel movements, with or without abdominal pain or abdominal discomfort, which is aggravated by spicy and cold food. The tongue is fat, the tongue is pale and dark, with tooth marks, the tongue coating is yellow, greasy and slippery, the pulse is deep and moist, and it is weak when taken hard, especially the radial pulse.

[0003] The disease recurs frequently, which, on the one hand, affects the patient's work, study, life and mental health and reduces the quality of life. On the other hand, long-term damage to the patient's innate foundation (kidney) and acquired foundation (spleen) will lead to weakening of the patient's constitution, reduced immunity, allergic reactions and other diseases, which will consume a lot of medical resources and increase the burden of medical care.

[0004] At present, there is no specific medicine for mixed cold and heat abdominal distension and diarrhea. It mainly depends on patients to improve their living and eating habits to alleviate or eliminate the disease. However, the diet therapy cycle is long and the effect is not obvious. Improper use of drugs will aggravate the condition. Western medicine treatment mainly focuses on regulating gastrointestinal motility, antidiarrheal drugs and intestinal microecological preparations, but it can only improve symptoms in the short term, is prone to relapse, and the long-term effect is not ideal.

[0005] Therefore, the present invention provides a Chinese medicine composition and a preparation method for treating abdominal distension and diarrhea of ​​mixed cold and heat type. Summary of the invention

[0006] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type.

[0007] To achieve the above object, on the one hand, the present invention provides a traditional Chinese medicine composition for treating abdominal distension and diarrhea with intermingled cold and heat syndromes. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Pogostemon cablin 3 - 6 parts, dried ginger 3 - 10 parts, Eucommia ulmoides 3 - 12 parts, Scutellaria baicalensis 3 - 10 parts, Coptis chinensis 2 - 6 parts, stir-fried Coix lacryma-jobi 10 - 20 parts, Pinellia ternata 6 - 10 parts, Citrus reticulata Blanco 3 - 10 parts, Poria cocos 10 - 15 parts, stir-fried Atractylodes macrocephala 6 - 10 parts, Corydalis yanhusuo processed with vinegar 6 - 10 parts, Bupleurum chinense processed with vinegar 6 - 10 parts, Areca peel 6 - 10 parts, Ligusticum chuanxiong 6 - 10 parts, Magnolia officinalis 6 - 10 parts, stir-fried Crataegus pinnatifida 6 - 10 parts, Platycodon grandiflorum 3 - 6 parts, roasted Glycyrrhiza uralensis 3 - 10 parts.

[0008] Preferably, the traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Pogostemon cablin 4 - 5 parts, dried ginger 6 - 8 parts, Eucommia ulmoides 8 - 10 parts, Scutellaria baicalensis 5 - 8 parts, Coptis chinensis 3 - 4 parts, stir-fried Coix lacryma-jobi 15 - 18 parts, Pinellia ternata 7 - 8 parts, Citrus reticulata Blanco 5 - 8 parts, Poria cocos 12 - 15 parts, stir-fried Atractylodes macrocephala 8 - 10 parts, Corydalis yanhusuo processed with vinegar 8 - 10 parts, Bupleurum chinense processed with vinegar 8 - 10 parts, Areca peel 8 - 10 parts, Ligusticum chuanxiong 8 - 10 parts, Magnolia officinalis 8 - 10 parts, stir-fried Crataegus pinnatifida 8 - 10 parts, Platycodon grandiflorum 4 - 5 parts, roasted Glycyrrhiza uralensis 6 - 8 parts.

[0009] Preferably, the traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: Pogostemon cablin 5 parts, dried ginger 10 parts, Eucommia ulmoides 10 parts, Scutellaria baicalensis 6 parts, Coptis chinensis 3 parts, stir-fried Coix lacryma-jobi 20 parts, Pinellia ternata 10 parts, Citrus reticulata Blanco 10 parts, Poria cocos 15 parts, stir-fried Atractylodes macrocephala 10 parts, Corydalis yanhusuo processed with vinegar 10 parts, Bupleurum chinense processed with vinegar 10 parts, Areca peel 10 parts, Ligusticum chuanxiong 10 parts, Magnolia officinalis 10 parts, stir-fried Crataegus pinnatifida 10 parts, Platycodon grandiflorum 5 parts, roasted Glycyrrhiza uralensis 10 parts.

[0010] On the one hand, the present invention also provides a drug for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, including the above traditional Chinese medicine composition, and may or may not include pharmaceutically acceptable excipients.

[0011] Preferably, the drug is an oral preparation.

[0012] Preferably, the oral preparation is a solid preparation or a liquid preparation.

[0013] Preferably, the solid preparation or the liquid preparation is one of pills, granules, capsules, tablets, powders, ointments, oral liquids, decoctions or powders.

[0014] On the one hand, the present invention also provides a traditional Chinese medicine water pill for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, which is prepared from the above traditional Chinese medicine composition as the raw material.

[0015] On the one hand, the present invention also provides a preparation method of a traditional Chinese medicine water pill for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, including the following steps:

[0016] S1. Weigh each raw medicinal material according to weight, mix, wash and dry;

[0017] S2, crushing the washed and dried raw medicinal materials, passing through a 100-mesh sieve to obtain medicinal powder, and controlling the sieving rate to be ≥95%;

[0018] S3, adding water to the powder and stirring for 20-30 minutes, making pills and drying them in a vacuum drying oven at 40-45°C to obtain Chinese medicine water pills;

[0019] The volume ratio of the water to the total mass of the raw medicinal materials is approximately 3:10.

[0020] On the one hand, the present invention also provides the use of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating abdominal distension and diarrhea of ​​mixed cold and heat type.

[0021] It should be noted that the pharmacological effects of some of the raw materials in the formula of the present invention are as follows:

[0022] Patchouli: The dried aerial part of the plant Pogostemon cablin (Blanco) Benth. of the Lamiaceae family. Nature and flavor and meridians: pungent, slightly warm. It enters the spleen, stomach, and lung meridians. Functions and indications: aromatic to clear turbidity, harmonize the middle and stop vomiting, release the wind and relieve heat. It is used for dampness and turbidity blocking the middle, abdominal distension and vomiting, summer dampness and external symptoms, initial onset of damp-heat, fever and fatigue, chest tightness and discomfort, cold and dampness blocking summer heat, abdominal pain, vomiting and diarrhea, and sinusitis and headache.

[0023] Dried ginger: dried rhizome of Zingiber officinale Rosc., a plant of the ginger family. Nature and flavor and meridians: pungent, hot. Enters the spleen, stomach, kidney, heart, and lung meridians. Functions and indications: warms the middle and dispels cold, restores yang and unclogs the meridians, warms the lungs and transforms fluid. Used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, asthma and cough due to cold fluid.

[0024] Eucommia ulmoides: The dried bark of Eucommia ulmoides Oliv., a plant of the Eucommia family. Nature and flavor and meridians: sweet, warm. Enters the liver and kidney meridians. Functions and indications: nourishes the liver and kidneys, strengthens the tendons and bones, and stabilizes the fetus. Used for liver and kidney deficiency, soreness of the waist and knees, weakness of the tendons and bones, dizziness, bleeding during pregnancy, and restless fetuses.

[0025] Scutellaria baicalensis: The dried root of Scutellaria baicalensisgeorgi, a plant of the Labiatae family. Nature and flavor and meridians: bitter, cold. Enters the lung, gallbladder, spleen, large intestine, and small intestine meridians. Functions and indications: clearing away heat and dampness, purging fire and detoxifying, stopping bleeding, and calming the fetus. Used for damp-heat, summer-heat dampness, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, lung heat cough, high fever and thirst, blood heat vomiting and bleeding, carbuncle, sore, and fetal movement disorder.

[0026] Rhizoma Coptidis: The dried rhizome of Coptis chinensis Franch., Coptis deltoidea C.Y.Cheng et Hsiao, or Coptis teeta Wall. (Ranunculaceae). Properties and Channels Entered: Bitter, cold. Enter the heart, spleen, stomach, liver, gallbladder, and large intestine channels. Functions and Indications: Clear heat and dry dampness, purge fire and detoxify. Used for damp-heat obstruction in the chest and epigastrium, vomiting with acid regurgitation, diarrhea, jaundice, high fever with coma, hyperactivity of heart fire, restlessness and insomnia, palpitations, hematemesis and epistaxis due to blood heat, red eyes, toothache, excessive thirst, carbuncles, sores, and boils; externally for eczema, moist sores, and purulent discharge from the ear canal.

[0027] Semen Coicis: The dried ripe semen of Coix lacryma-jobi var. mayuen (Poaceae). Properties and Channels Entered: Sweet, bland, cool. Enter the spleen, stomach, and lung channels. Functions and Indications: Promote diuresis and percolate dampness, strengthen the spleen and stop diarrhea, relieve arthralgia, expel pus, detoxify and dissipate nodules. Used for edema, beriberi, dysuria, diarrhea due to spleen deficiency, damp arthralgia with contracture, lung abscess, intestinal abscess, verruca, and cancer. Stir-fried Semen Coicis is milder in its cold nature and is more effective in strengthening the spleen and stopping diarrhea, and can be used for diarrhea due to spleen deficiency, reduced appetite, and abdominal distension.

[0028] Rhizoma Pinelliae Praeparatum: The processed product of Rhizoma Pinelliae (the dried tuber of Pinellia ternata (Thunb.) Breit., Araceae). Properties and Channels Entered: Pungent, warm. Enter the spleen, stomach, and lung channels. Functions and Indications: Dry dampness and resolve phlegm. Used for cough with copious phlegm due to dampness, fullness and discomfort in the stomach and epigastrium, and the accumulation of phlegm that cannot be expectorated.

[0029] Pericarpium Citri Reticulatae: The dried ripe pericarp of Citrus reticulata Blanco and its cultivated varieties (Rutaceae). Properties and Channels Entered: Bitter, pungent, warm. Enter the lung and spleen channels. Functions and Indications: Regulate qi and strengthen the spleen, dry dampness and resolve phlegm. Used for abdominal distension and fullness, reduced appetite, vomiting, diarrhea, and cough with copious phlegm.

[0030] Poria: The dried sclerotium of Poria cocos (Schw.) Wolf (Polyporaceae). Properties and Channels Entered: Sweet, bland, neutral. Enter the heart, lung, spleen, and kidney channels. Functions and Indications: Promote diuresis and percolate dampness, strengthen the spleen, calm the heart. Used for edema with oliguria, dizziness and palpitation due to phlegm-fluid retention, reduced appetite due to spleen deficiency, loose stools, restlessness, palpitation, and insomnia.

[0031] Rhizoma Atractylodis Macrocephalae: The dried rhizome of Atractylodes macrocephala Koidz. (Asteraceae). Stir-fried Rhizoma Atractylodis Macrocephalae with bran is prepared by sprinkling the honey-fried bran into a hot wok, adding slices of Rhizoma Atractylodis Macrocephalae when it starts to smoke, stir-frying until it turns yellowish-brown and emits a burnt aroma, then removing it and sifting out the honey-fried bran. Properties and Channels Entered: Bitter-sweet, sweet, warm. Enter the spleen and stomach channels. Functions and Indications: Tonify the spleen and boost qi, dry dampness and promote diuresis, stop sweating, prevent miscarriage. Used for reduced appetite due to spleen deficiency, abdominal distension and diarrhea, dizziness and palpitation due to phlegm-fluid retention, edema, spontaneous sweating, and threatened abortion.

[0032] Rhizoma Corydalis (Yanhusuo): The dried tuber of Corydalis yanhusuo W.T.Wang, a plant of the Papaveraceae family. Vinegar-processed Rhizoma Corydalis is obtained by taking clean Rhizoma Corydalis, stir-frying it dry according to the vinegar-frying method (General Rule 0213), or boiling it until the vinegar is completely absorbed, cutting it into thick slices or pounding it before use. Properties and Channels Entered: Pungent, bitter, warm. Enter the liver and spleen channels. Functions and Indications: Promote blood circulation, activate qi flow, and relieve pain. It is used for chest and hypochondriac pain, epigastric and abdominal pain, angina pectoris, amenorrhea and dysmenorrhea, stasis obstruction after childbirth, and swelling and pain from falls and bruises.

[0033] Radix Bupleuri: The dried root of Bupleurum chinense DC. or Bupleurum scorzonerifolium Willd., plants of the Umbelliferae family. Vinegar-processed Radix Bupleuri is obtained by taking slices of Radix Bupleuri and stir-frying them dry according to the vinegar-frying method (General Rule 0213). Properties and Channels Entered: Pungent, bitter, slightly cold. Enter the liver, gallbladder, and lung channels. Functions and Indications: Dispel wind and heat, soothe the liver and relieve depression, and raise yang qi. It is used for common cold with fever, alternating chills and fever, chest and hypochondriac distending pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0034] Pericarpium Arecae: The dried pericarp of Areca catechu L., a plant of the Palmae family. Properties and Channels Entered: Pungent, slightly warm. Enter the spleen, stomach, large intestine, and small intestine channels. Functions and Indications: Promote qi flow in the middle energizer and promote diuresis to reduce edema. It is used for dampness obstruction and qi stagnation, fullness and distension in the epigastrium and abdomen, discomfort in defecation, edema and distension, beriberi edema, and dysuria.

[0035] Rhizoma Chuanxiong: The dried rhizome of Ligusticum chuanxiong Hort., a plant of the Umbelliferae family. Properties and Channels Entered: Pungent, warm. Enter the liver, gallbladder, and pericardium channels. Functions and Indications: Promote blood circulation and qi flow, dispel wind and relieve pain. It is used for angina pectoris, chest and hypochondriac stabbing pain, swelling and pain from falls and bruises, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to mass in the abdomen, headache, and rheumatic arthralgia.

[0036] Cortex Magnoliae Officinalis: The dried trunk bark, root bark, and branch bark of Magnolia officinalis Rehd. et Wils. or Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., plants of the Magnoliaceae family. Properties and Channels Entered: Bitter, pungent, warm. Enter the spleen, stomach, lung, and large intestine channels. Functions and Indications: Dry dampness and resolve phlegm, lower qi and relieve fullness. It is used for dampness stagnation damaging the middle energizer, fullness and vomiting and diarrhea in the epigastrium and abdomen, food accumulation and qi stagnation, abdominal distension and constipation, and cough and asthma due to phlegm retention.

[0037] Hawthorn: The dried ripe fruit of Crataegus pinnatifida Bge. var. major N.E. Br. or Crataegus pinnatifida Bge. of the Rosaceae family. Stir-fried Hawthorn is obtained by taking pure Hawthorn and stir-frying it according to the method of clear stir-frying (General Rule 0213) until the color becomes darker. Nature, flavor, and meridian tropism: Sour, sweet, slightly warm. It belongs to the spleen, stomach, and liver meridians. Functions and indications: Promote digestion and strengthen the stomach, promote qi circulation and disperse stasis, transform turbidity and reduce lipid. It is used for food stagnation, fullness in the stomach cavity, diarrhea and abdominal pain, amenorrhea due to blood stasis, postpartum stasis obstruction, stabbing pain in the heart and abdomen, chest impediment pain, hernia pain, and hyperlipidemia. Stir-fried Hawthorn with coke enhances the function of promoting digestion and inducing purgation. It is used for food stagnation and unsmooth diarrhea.

[0038] Platycodon Root: The dried root of Platycodon grandiflorum (Jacq.) A. DC. of the Campanulaceae family. Nature, flavor, and meridian tropism: Bitter, pungent, flat. It belongs to the lung meridian. Functions and indications: Disperse the lung qi, soothe the throat, resolve phlegm, and drain pus. It is used for excessive cough and phlegm, chest tightness and discomfort, sore throat and hoarse voice, and lung abscess with expectoration of pus.

[0039] Fried Licorice Root: The processed product of Licorice Root (the dried root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat., or Glycyrrhiza glabra L. of the Leguminosae family). Nature, flavor, and meridian tropism: Sweet, flat. It belongs to the heart, lung, spleen, and stomach meridians. Functions and indications: Tonify the spleen and stomach, replenish qi and restore the pulse. It is used for weakness of the spleen and stomach, lassitude and fatigue, palpitation, and intermittent pulse.

[0040] It should also be noted here that the usage method of the water pills prepared in the present invention is: 3 - 5 g (13 - 17 pills) once (the specific dosage is determined according to the severity of the condition), twice a day.

[0041] The present invention has the following beneficial effects:

[0042] The monarch drugs of the traditional Chinese medicine composition provided by the present invention are Pogostemon cablin, dried ginger, and Eucommia ulmoides. Pogostemon cablin aromatizes turbidity and raises the clear and descends the turbid. Dried ginger warms the spleen yang. Eucommia ulmoides warms the kidney yang, which is the fundamental for treating diseases. The ministerial drugs are Coptis chinensis and Scutellaria baicalensis, which are bitter and cold in nature and can reduce dampness and heat by purging downward. Coix seed clears and promotes dampness and heat and can also strengthen the spleen. Pinellia ternata and Tangerine Peel dry dampness and resolve phlegm, regulate qi and strengthen the spleen. Poria cocos and Atractylodes macrocephala strengthen the spleen and eliminate dampness. Bupleurum chinense, Corydalis yanhusuo, Areca peel, Magnolia officinalis, and Hawthorn regulate qi and relieve distension, promote digestion and induce purgation, promote qi circulation and relieve pain. Adding Ligusticum wallichii enhances the effect of regulating qi and activating blood circulation and raises the qi in the blood. The assistant and envoy drugs are Fried Licorice Root to harmonize all the drugs, tonify the spleen and stomach, and Platycodon Root to disperse the lung qi, achieving the effect of dispersing the upper and promoting the flow of qi in the lower. All the drugs work together to treat both the symptoms and the root cause, warm and tonify the yang of the spleen and kidney, clear and remove dampness and heat in the middle energizer, relieve distension and eliminate dampness, and disperse the upper and promote the flow of qi in the lower. Detailed implementation mode

[0043] To enable those skilled in the art to better understand the solution of the present invention, the technical solution of the present invention will be further described in detail below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative work shall fall within the scope of protection of the present invention.

[0044] It should be noted that, without conflict, the embodiments in the present invention and the features in the embodiments can be combined with each other. The present invention will be described in detail below in conjunction with the embodiments.

[0045] Embodiment 1:

[0046] A preparation method of traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, comprising the following steps:

[0047] S1. Weigh each raw material medicinal herb according to the weight parts of 5 parts of Pogostemon cablin, 10 parts of dried ginger, 10 parts of Eucommia ulmoides, 6 parts of Scutellaria baicalensis, 3 parts of Coptis chinensis, 20 parts of stir-fried Coix lacryma-jobi, 10 parts of Pinellia ternata, 10 parts of Citrus reticulata Blanco, 15 parts of Poria cocos, 10 parts of stir-fried Atractylodes macrocephala Koidz, 10 parts of Corydalis yanhusuo processed with vinegar, 10 parts of Bupleurum chinense DC. processed with vinegar, 10 parts of Areca peel, 10 parts of Ligusticum chuanxiong Hort, 10 parts of Magnolia officinalis Rehd. et Wils, 10 parts of stir-fried Crataegus pinnatifida Bunge, 5 parts of Platycodon grandiflorum, and 10 parts of roasted Glycyrrhiza uralensis Fisch, mix them and then wash and dry; wherein 1 weight part = 100 g.

[0048] S2. Crush the above-mentioned washed and dried raw material medicinal herbs, pass through a 100-mesh sieve to obtain medicinal powder, and control the sieving rate ≥ 95%;

[0049] S3. Add 5.2 L of water to the medicinal powder, stir well for 20 minutes, then make a number of pills and place them in a vacuum drying oven at 45 °C for drying to obtain traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes.

[0050] Embodiment 2:

[0051] A preparation method of traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, comprising the following steps:

[0052] S1. Weigh each raw material medicinal herb according to the weight parts of 3 parts of Pogostemon cablin, 3 parts of dried ginger, 3 parts of Eucommia ulmoides, 3 parts of Scutellaria baicalensis, 2 parts of Coptis chinensis, 10 parts of stir-fried Coix lacryma-jobi, 6 parts of Pinellia ternata, 3 parts of Citrus reticulata Blanco, 10 parts of Poria cocos, 6 parts of stir-fried Atractylodes macrocephala Koidz, 6 parts of Corydalis yanhusuo processed with vinegar, 6 parts of Bupleurum chinense DC. processed with vinegar, 6 parts of Areca peel, 6 parts of Ligusticum chuanxiong Hort, 6 parts of Magnolia officinalis Rehd. et Wils, 6 parts of stir-fried Crataegus pinnatifida Bunge, 3 parts of Platycodon grandiflorum, and 3 parts of roasted Glycyrrhiza uralensis Fisch, mix them and then wash and dry; wherein 1 weight part = 100 g.

[0053] S2. Crush the above-mentioned washed and dried raw material medicinal herbs, pass through a 100-mesh sieve to obtain medicinal powder, and control the sieving rate ≥ 95%;

[0054] S3. After adding 3 L of water to the medicinal powder and stirring well for 30 minutes, make a number of pills and dry them in a vacuum drying oven at 40 °C to obtain the traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes.

[0055] Example 3:

[0056] A preparation method of traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, comprising the following steps:

[0057] S1. Weigh each raw medicinal material according to the weight parts of 6 parts of Pogostemon cablin, 10 parts of dried ginger, 12 parts of Eucommia ulmoides, 10 parts of Scutellaria baicalensis, 6 parts of Coptis chinensis, 20 parts of stir-fried Coix lacryma-jobi, 10 parts of Pinellia ternata, 10 parts of Citrus reticulata Blanco, 15 parts of Poria cocos, 10 parts of stir-fried Atractylodes macrocephala Koidz., 10 parts of Corydalis yanhusuo processed with vinegar, 10 parts of Bupleurum chinense DC. processed with vinegar, 10 parts of Areca peel, 10 parts of Ligusticum chuanxiong Hort., 10 parts of Magnolia officinalis Rehd. et Wils., 10 parts of stir-fried Crataegus pinnatifida Bge., 6 parts of Platycodon grandiflorum, and 10 parts of roasted Glycyrrhiza uralensis Fisch., mix them and then wash and dry; where 1 weight part = 100 g.

[0058] S2. Crush the above-mentioned washed and dried raw medicinal materials, pass through a 100-mesh sieve to obtain medicinal powder, and control the sieving rate ≥ 95%;

[0059] S3. After adding 5.5 L of water to the medicinal powder and stirring well for 25 minutes, make a number of pills and dry them in a vacuum drying oven at 42 °C to obtain the traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes.

[0060] Example 4:

[0061] A preparation method of traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes, comprising the following steps:

[0062] S1. Weigh each raw medicinal material according to the weight parts of 4 parts of Pogostemon cablin, 6 parts of dried ginger, 8 parts of Eucommia ulmoides, 5 parts of Scutellaria baicalensis, 3 parts of Coptis chinensis, 15 parts of stir-fried Coix lacryma-jobi, 7 parts of Pinellia ternata, 5 parts of Citrus reticulata Blanco, 12 parts of Poria cocos, 8 parts of stir-fried Atractylodes macrocephala Koidz., 8 parts of Corydalis yanhusuo processed with vinegar, 8 parts of Bupleurum chinense DC. processed with vinegar, 8 parts of Areca peel, 8 parts of Ligusticum chuanxiong Hort., 8 parts of Magnolia officinalis Rehd. et Wils., 8 parts of stir-fried Crataegus pinnatifida Bge., 4 parts of Platycodon grandiflorum, and 6 parts of roasted Glycyrrhiza uralensis Fisch., mix them and then wash and dry; where 1 weight part = 100 g.

[0063] S2. Crush the above-mentioned washed and dried raw medicinal materials, pass through a 100-mesh sieve to obtain medicinal powder, and control the sieving rate ≥ 95%;

[0064] S3. After adding 4 L of water to the medicinal powder and stirring well for 30 minutes, make a number of pills and dry them in a vacuum drying oven at 45 °C to obtain the traditional Chinese medicine water pills for treating abdominal distension and diarrhea with intermingled cold and heat syndromes.

[0065] Example 5:

[0066] A preparation method of traditional Chinese medicine water pills for treating abdominal distension and diarrhea with mixed cold and heat syndromes, comprising the following steps:

[0067] S1. Weigh each raw material medicinal herb according to the weight parts of 5 parts of Pogostemon cablin, 8 parts of dried ginger, 10 parts of Eucommia ulmoides, 8 parts of Scutellaria baicalensis, 4 parts of Coptis chinensis, 18 parts of stir-fried Coix lacryma-jobi, 8 parts of Pinellia ternata, 8 parts of Citrus reticulata Blanco, 15 parts of Poria cocos, 10 parts of stir-fried Atractylodes macrocephala Koidz., 10 parts of Corydalis yanhusuo processed with vinegar, 10 parts of Bupleurum chinense DC. processed with vinegar, 10 parts of Areca peel, 10 parts of Ligusticum chuanxiong Hort., 10 parts of Magnolia officinalis Rehd. et Wils., 10 parts of stir-fried Crataegus pinnatifida Bge., 5 parts of Platycodon grandiflorum, and 8 parts of roasted Glycyrrhiza uralensis Fisch., mix them and then wash and dry; where 1 weight part = 100 g.

[0068] S2. Crush the above-mentioned washed and dried raw material medicinal herbs, pass through a 100-mesh sieve to obtain medicinal powder, and control the sieving rate ≥ 95%;

[0069] S3. Add 5 L of water to the medicinal powder, stir well for 20 minutes, then make a number of pills and place them in a vacuum drying oven at 40 °C for drying to obtain traditional Chinese medicine water pills for treating abdominal distension and diarrhea with mixed cold and heat syndromes.

[0070] The instruments and methods involved in Examples 1 - 5 are common equipment and methods in the field of traditional Chinese medicine preparations.

[0071] Clinical trial cases:

[0072] To prove that the traditional Chinese medicine water pills prepared from the traditional Chinese medicine composition of the present invention have a positive effect on treating abdominal distension and diarrhea with mixed cold and heat syndromes. The inventor conducted a clinical trial on patients with abdominal distension and diarrhea with mixed cold and heat syndromes using the traditional Chinese medicine water pills prepared in Example 1. Now, some clinical trial reports are selected as follows:

[0073] 1. Leng x, male, 36 years old. Chief complaint: Loose stools, occurring three to five times a day, with abdominal distension, fullness, gurgling, and bad breath for many years; accompanied by coldness in both lower extremities, dark red tongue, yellow and greasy coating, soft pulse, and strong liver pulse. Diagnosis: Diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after meals in the morning and evening.

[0074] Follow-up visit: Abdominal distension disappeared, stools were normal, the darkening of the tongue was reduced, the coating was thin and white, and the pulse was stronger when taken deeply compared with before.

[0075] 2. Guo xx, female, 57 years old. Chief complaint: Persistent abdominal distension and loose stools; pale and dark tongue, thin yellow and greasy coating, deep and soft pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat).

[0076] Medication for half a month: 15 pills after meals in the morning and evening.

[0077] Follow-up visit: Abdominal distension disappeared, stools were normal, the darkening of the tongue was reduced, the coating was thin and white, and the pulse was stronger when taken deeply compared with before.

[0078] 3. Liu xx, male, 63 years old. Chief complaint: Abdominal distension, loose stools for many years, and foul breath; pale and dull tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 tablets after meals in the morning and evening.

[0079] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0080] 4. Zhang xx, male, 69 years old. Chief complaint: Abdominal distension for many years, accompanied by diarrhea, 2 - 3 times a day; dark red tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 tablets after meals in the morning and evening.

[0081] Follow-up visit: Abdominal distension disappeared, stools were normal, the tongue was normal, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0082] 5. Zhang xx, male, 72 years old. Chief complaint: Abdominal distension for many years, loose stools when the mood changes, up to four or five times a day at worst, accompanied by mild abdominal pain; pale and dull tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 tablets after meals in the morning and evening.

[0083] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0084] 6. Guo x, female, 48 years old. Chief complaint: Epigastric and abdominal distension for three months, accompanied by sometimes loose stools, 2 - 3 times a day, sometimes difficult defecation, once every two days, with a foul smell; pale and dull tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 12 tablets after meals in the morning and evening.

[0085] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0086] 7. Zhang xx, male, 53 years old. Chief complaint: Abdominal distension for many years, aggravated after drinking, accompanied by diarrhea and bitter taste in the mouth; dark red tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 tablets after meals in the morning and evening.

[0087] Follow-up visit: Abdominal distension disappeared, stools were normal, the tongue was normal, the dullness of the tongue was relieved, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0088] 8. Dong xx, male, 68 years old. Chief complaint: Abdominal distension, cold limbs, gastric discomfort, loose stools, 2 - 3 times a day, accompanied by bad breath; pale and dull tongue, thin yellow and greasy coating, deep and soggy pulse. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 tablets after meals in the morning and evening.

[0089] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the coating was thin and white, and the deep pulse was stronger than before when taken deeply.

[0090] 9. Zhang xx, male, 58 years old. Chief complaint: Abdominal distension for many years, general fever in the afternoon, chills in the evening, diarrhea occurring three or four times a day; the tongue is dull red, the tongue coating is thin, yellow and greasy, and the pulse is deep and soft. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 pills after breakfast and dinner every day.

[0091] Follow-up visit: Abdominal distension disappeared, stools were normal, the tongue was dull and normal, the tongue coating was thin and white, and the pulse was stronger when taken deeply compared to before.

[0092] 10. Cao xx, male, 57 years old. Chief complaint: Loose stools and abdominal distension for many years, bitter taste in the mouth; the tongue is pale and dull, the tongue coating is thin, yellow and greasy, and the pulse is deep and soft. Diagnosis: Diarrhea (mixture of cold and heat), abdominal distension (mixture of cold and heat).

[0093] Medication for half a month: 15 pills after breakfast and dinner every day.

[0094] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the tongue coating was thin and white, and the pulse was stronger when taken deeply compared to before.

[0095] 11. Lin x, female, 32 years old. Chief complaint: Unformed stools, three to four times a day, cold in the lower extremities, accompanied by abdominal distension and fullness, sticky feeling in the mouth, the tongue is pale, plump, dull, with a white and slightly yellowish greasy coating, and the pulse is deep, soft, and weak at the chi position. Diagnosis: Diarrhea (mixture of cold and heat). Medication for half a month: 12 pills after breakfast and dinner every day.

[0096] Follow-up visit: Stools were formed, once a day, abdominal distension and fullness, sticky feeling in the mouth, cold in the lower extremities was relieved, the tongue was pale and dull, the tongue coating was thin and white, and the pulse was deep and weak at the chi position.

[0097] 12. Li xx, male, 46 years old. Chief complaint: Abdominal distension and bad breath, unsmooth stools; the tongue is dull red, the tongue coating is thin, yellow and greasy, and the pulse is deep and soft. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 pills after breakfast and dinner every day.

[0098] Follow-up visit: Abdominal distension disappeared, stools were normal, the tongue was normal, the tongue coating was thin and white, and the pulse was stronger when taken deeply compared to before.

[0099] 13. Wang xx, male, 59 years old. Chief complaint: Epigastric distension for many years, diarrhea after getting angry, the tongue is pale and dull, the tongue coating is thin, yellow and greasy, and the pulse is deep and soft. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 12 pills after breakfast and dinner every day.

[0100] Follow-up visit: Abdominal distension disappeared, stools were normal, the dullness of the tongue was relieved, the tongue coating was thin and white, and the pulse was stronger when taken deeply compared to before.

[0101] 14. Chen xx, male, 66 years old. Chief complaint: Long-term abdominal distension, accompanied by sometimes loose stools, two or three times a day, sometimes unsmooth defecation; once every two days, with a strong and foul smell, the tongue is pale and dull, the tongue coating is thin, yellow and greasy, and the pulse is deep and soft. Diagnosis: Abdominal distension (mixture of cold and heat), diarrhea (mixture of cold and heat). Medication for half a month: 15 pills after breakfast and dinner every day.

[0102] Follow-up visit: Abdominal distension disappeared, bowel movements returned to normal, the dullness of the tongue was alleviated, the tongue coating was thin and white, and the pulse was deep and forceful upon heavy pressure compared to before.

[0103] 15. Wu xx, male, 46 years old. Chief complaint: Loose stools, having 5 - 6 bowel movements per day, abdominal distension for many years, sticky mouth and bitter taste; pale and dull tongue, thin yellow and greasy tongue coating, deep and moderate pulse. Diagnosis: Diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after meals in the morning and evening.

[0104] Follow-up visit: Abdominal distension disappeared, bowel movements returned to normal, the dullness of the tongue was alleviated, the tongue coating was thin and white, and the pulse was deep and forceful upon heavy pressure compared to before.

[0105] 16. Lin x, male, 58 years old. Chief complaint: Persistent abdominal distension, loose stools 3 - 4 times a day, resulting in poor sleep and hot palms; pale and dull tongue, thin yellow and greasy tongue coating, deep and moderate pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after meals in the morning and evening.

[0106] Follow-up visit: Abdominal distension disappeared, bowel movements returned to normal, sleep improved, the dullness of the tongue was alleviated, the tongue coating was thin and white, and the pulse was deep and forceful upon heavy pressure compared to before.

[0107] 17. Liu xx, female, 30 years old. Chief complaint: Loose stools for five to six years, aggravated by consuming cold drinks, spicy and greasy foods, up to five to seven times a day at worst, accompanied by gastric discomfort, abdominal distension, acid reflux, cold hands and feet, and scanty menstruation, enlarged and pale tongue with a dull color, white and slightly yellowish greasy tongue coating, deep and moderate pulse, weak on the chi position. Diagnosis: Diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after meals in the morning and evening.

[0108] Follow-up visit: Loose stools disappeared, having one bowel movement per day, formed stools, gastric discomfort and acid reflux disappeared, no abdominal distension, cold hands and feet were alleviated, menstruation came, the tongue was slightly enlarged, with a dull color and formed, the tongue coating was thin and white, and the pulse was deep and weak on the chi position.

[0109] In summary, the traditional Chinese medicine composition of the present invention and the traditional Chinese medicine pills prepared using the above traditional Chinese medicine composition have significant effects in treating abdominal distension and diarrhea of the type of mixed cold and heat.

[0110] This specific embodiment is only an explanation of the present invention and is not a limitation thereof. Those skilled in the art can make modifications to this embodiment without creative contributions according to their needs after reading this specification, but as long as they are within the scope of the claims of the present invention, they are protected by the patent law.

Claims

1. A Chinese medicine composition for treating abdominal distension and diarrhea caused by mixed cold and heat, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 3-6 parts of patchouli, 3-10 parts of dried ginger, 3-12 parts of eucommia bark, 3-10 parts of scutellaria baicalensis, 2-6 parts of coptis chinensis, 10-20 parts of stir-fried coix seeds, 6-10 parts of pinellia ternata, 3-10 parts of tangerine peel, 10-15 parts of poria, 6-10 parts of stir-fried atractylodes macrocephala with bran, 6-10 parts of vinegar-corydalis, 6-10 parts of vinegar-bupleurum, 6-10 parts of tangerine peel, 6-10 parts of ligusticum chuanxiong, 6-10 parts of magnolia bark, 6-10 parts of stir-fried hawthorn, 3-6 parts of platycodon grandiflorum, and 3-10 parts of roasted liquorice.

2. A Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 4-5 parts of patchouli, 6-8 parts of dried ginger, 8-10 parts of eucommia bark, 5-8 parts of scutellaria baicalensis, 3-4 parts of coptis chinensis, 15-18 parts of stir-fried coix seeds, 7-8 parts of pinellia ternata, 5-8 parts of tangerine peel, 12-15 parts of poria, 8-10 parts of stir-fried atractylodes macrocephala with bran, 8-10 parts of vinegar-corydalis, 8-10 parts of vinegar-bupleurum, 8-10 parts of tangerine peel, 8-10 parts of ligusticum chuanxiong, 8-10 parts of magnolia bark, 8-10 parts of stir-fried hawthorn, 4-5 parts of platycodon grandiflorum, and 6-8 parts of roasted liquorice.

3. A Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 1, characterized in that: The Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 5 parts of patchouli, 10 parts of dried ginger, 10 parts of eucommia bark, 6 parts of scutellaria baicalensis, 3 parts of coptis chinensis, 20 parts of stir-fried coix seeds, 10 parts of pinellia ternata, 10 parts of tangerine peel, 15 parts of poria, 10 parts of stir-fried atractylodes macrocephala with bran, 10 parts of vinegar-corydalis, 10 parts of vinegar-bupleurum, 10 parts of tangerine peel, 10 parts of ligusticum chuanxiong, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn, 5 parts of platycodon grandiflorum, and 10 parts of roasted liquorice.

4. A medicine for treating abdominal distension and diarrhea of ​​mixed cold and heat type, comprising the Chinese medicine composition according to any one of claims 1 to 3, and also comprising pharmaceutically acceptable excipients.

5. The drug according to claim 4, characterized in that The medicine is an oral preparation.

6. The drug according to claim 4, characterized in that The oral preparation is a solid preparation or a liquid preparation.

7. The drug according to claim 6, characterized in that The solid preparation or liquid preparation is one of pills, granules, capsules, tablets, powders, pastes, oral liquids, decoctions or powders.

8. A Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type, characterized in that: The Chinese medicine water pill is prepared using the Chinese medicine composition described in any one of claims 1 to 3 as a raw material.

9. The method for preparing the Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 8, characterized in that: The steps include: S1. Weigh each raw medicinal material according to weight, mix, wash and dry; S2, crushing the washed and dried raw medicinal materials, passing through a 100-mesh sieve to obtain medicinal powder, and controlling the sieving rate to be ≥95%; S3, adding water to the powder and stirring for 20-30 minutes, making pills and drying them in a vacuum drying oven at 40-45°C to obtain Chinese medicine water pills; The volume ratio of the water to the total mass of the raw medicinal materials is approximately 3:

10.

10. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of a medicament for treating abdominal distension and diarrhea of ​​mixed cold and heat type.