A traditional Chinese medicine composition for treating abdominal distension and diarrhea with cold and heat symptoms and a preparation method thereof

Abstract

The application belongs to the technical field of traditional Chinese medicines, and discloses a traditional Chinese medicine composition for treating abdominal distension and diarrhea of cold-heat complex type and a preparation method thereof. The technical scheme points of the traditional Chinese medicine composition are as follows: the traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 3-6 parts of perilla, 3-10 parts of dried ginger, 3-12 parts of eucommia, 3-10 parts of scrophularia, 2-6 parts of coptis, 10-20 parts of fried coix seed, 6-10 parts of clear pinellia, 3-10 parts of dried tangerine or orange peel, 10-15 parts of poria, 6-10 parts of wheat-cooked atractylodes, 6-10 parts of vinegar-cured corydalis, 6-10 parts of vinegar-cured bupleurum, 6-10 parts of pericarpium zephyritae, 6-10 parts of chuanxiong, 6-10 parts of magnolia officinalis, 6-10 parts of fried hawthorn fruit, 3-6 parts of platycodon, and 3-10 parts of fried licorice. The traditional Chinese medicine composition and the traditional Chinese medicine water pill prepared from the traditional Chinese medicine composition have the effect of treating abdominal distension and diarrhea of cold-heat complex type.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and more specifically, to a traditional Chinese medicine composition and preparation method for treating abdominal distension and diarrhea of ​​mixed cold and heat type. Background Technology

[0002] People with lifestyle and dietary habits that involve staying up late, drinking cold beer, and eating barbecue, which are often associated with a mixture of hot and cold symptoms, are prone to damaging the spleen and kidney yang. This can lead to spleen dysfunction, internal damp-heat in the middle jiao (middle burner), and stagnation of qi in the middle jiao. The heart fire cannot descend to warm the kidney water, and the kidney water cannot ascend to nourish the heart fire, resulting in upper heat, lower cold, and damp-heat in the middle jiao. The patient's diagnosis is spleen and kidney yang deficiency, with excessive phlegm and dampness as the root cause, and damp-heat in the middle jiao as the manifestation, exhibiting a complex mixture of hot and cold symptoms. Symptoms include hot palms, a preference for cold drinks, abdominal distension after meals, occasional stomach upset and acid reflux, sticky and unformed stools, increased bowel movements, with or without abdominal pain or discomfort, which worsens with spicy or cold foods. The tongue is large, pale, and dark with teeth marks, and the coating is yellow, greasy, and slippery. The pulse is deep and weak, especially at the cun position.

[0003] The recurring nature of this disease affects patients' work, study, life, and mental health, reducing their quality of life. Furthermore, long-term damage to the innate foundation (kidneys) and acquired foundation (spleen) can lead to weakened constitution, reduced immunity, and allergic reactions, consuming significant medical resources and increasing the burden on healthcare.

[0004] Currently, there is no specific medicine for abdominal distension and diarrhea caused by a mixture of cold and heat patterns. Treatment mainly relies on patients improving their lifestyle and dietary habits to alleviate or eliminate the condition. However, dietary therapy has a long treatment period, limited effectiveness, and improper medication can worsen the condition. Western medicine treatment mainly uses gastrointestinal motility regulators, antidiarrheal drugs, and intestinal probiotics, but these only provide short-term symptom relief, are prone to relapse, and have less than ideal long-term efficacy.

[0005] Therefore, this invention proposes a traditional Chinese medicine composition and preparation method for treating abdominal distension and diarrhea of ​​mixed cold and heat type. Summary of the Invention

[0006] The purpose of this invention is to provide a traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type.

[0007] To achieve the above objectives, the present invention provides a traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type. The traditional Chinese medicine composition is composed of the following raw medicinal materials in parts by weight: 3-6 parts of patchouli, 3-10 parts of dried ginger, 3-12 parts of eucommia bark, 3-10 parts of scutellaria barbata, 2-6 parts of coptis chinensis, 10-20 parts of stir-fried coix seed, 6-10 parts of processed pinellia ternata, 3-10 parts of tangerine peel, 10-15 parts of poria cocos, 6-10 parts of stir-fried atractylodes macrocephala, 6-10 parts of vinegar-processed corydalis yanhusuo, 6-10 parts of vinegar-processed bupleurum chinense, 6-10 parts of areca peel, 6-10 parts of chuanxiong rhizome, 6-10 parts of magnolia bark, 6-10 parts of stir-fried hawthorn, 3-6 parts of platycodon grandiflorus, and 3-10 parts of prepared licorice root.

[0008] Preferably, the traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 4-5 parts of patchouli, 6-8 parts of dried ginger, 8-10 parts of eucommia bark, 5-8 parts of scutellaria baicalensis, 3-4 parts of coptis chinensis, 15-18 parts of stir-fried coix seed, 7-8 parts of processed pinellia ternata, 5-8 parts of tangerine peel, 12-15 parts of poria cocos, 8-10 parts of stir-fried atractylodes macrocephala, 8-10 parts of vinegar-processed corydalis yanhusuo, 8-10 parts of vinegar-processed bupleurum chinense, 8-10 parts of areca peel, 8-10 parts of chuanxiong rhizome, 8-10 parts of magnolia bark, 8-10 parts of stir-fried hawthorn fruit, 4-5 parts of platycodon grandiflorus, and 6-8 parts of prepared licorice root.

[0009] Preferably, the traditional Chinese medicine composition comprises the following raw medicinal materials in parts by weight: 5 parts of patchouli, 10 parts of dried ginger, 10 parts of eucommia bark, 6 parts of scutellaria baicalensis, 3 parts of coptis chinensis, 20 parts of stir-fried coix seed, 10 parts of processed pinellia ternata, 10 parts of tangerine peel, 15 parts of poria cocos, 10 parts of stir-fried atractylodes macrocephala, 10 parts of vinegar-processed corydalis yanhusuo, 10 parts of vinegar-processed bupleurum chinense, 10 parts of areca peel, 10 parts of chuanxiong rhizome, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn fruit, 5 parts of platycodon grandiflorus, and 10 parts of prepared licorice root.

[0010] On the one hand, the present invention also provides a medicine for treating abdominal distension and diarrhea of ​​mixed cold and heat type, comprising the above-mentioned traditional Chinese medicine composition, and including or excluding pharmaceutically acceptable excipients.

[0011] Preferably, the drug is an oral preparation.

[0012] Preferably, the oral formulation is a solid or liquid formulation.

[0013] Preferably, the oral preparation is one of the following: pills, granules, capsules, tablets, powders, ointments, oral liquids, or decoctions.

[0014] On the one hand, the present invention also provides a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type, wherein the traditional Chinese medicine water pill is prepared from the above-mentioned traditional Chinese medicine composition as raw material.

[0015] On the one hand, the present invention also provides a method for preparing traditional Chinese medicine water pills for treating abdominal distension and diarrhea of ​​mixed cold and heat type, comprising the following steps:

[0016] S1. Weigh each raw medicinal material according to the weight proportions, mix them, and then wash and dry them.

[0017] S2. After cleaning and drying, pulverize the raw medicinal materials and pass them through a 100-mesh sieve to obtain medicinal powder, controlling the sieve passing rate to ≥95%;

[0018] S3. After adding water to the powder and stirring thoroughly for 20-30 minutes, make pills and dry them in a vacuum drying oven at 40-45℃ to obtain Chinese medicine water pills;

[0019] The volume ratio of water to the total mass of the raw medicinal materials is approximately 3:10.

[0020] On the one hand, the present invention also provides the application of the above-mentioned traditional Chinese medicine composition in the preparation of a medicine for treating abdominal distension and diarrhea of ​​mixed cold and heat type.

[0021] It should be noted that the pharmacological effects of some of the medicinal materials in the formulation of this invention are as follows:

[0022] Patchouli: The dried aerial parts of *Pogostemon cablin* (Blanco) Benth., a plant in the Lamiaceae family. Properties and Channels Entered: Pungent, slightly warm. Enters the Spleen, Stomach, and Lung channels. Functions and Indications: Aromatic and dispels dampness, harmonizes the stomach and stops vomiting, releases exterior pathogens and relieves summer heat. Used for dampness obstructing the middle jiao, epigastric fullness and vomiting, summer-dampness syndrome, early stage of damp-heat syndrome, fever and fatigue, chest tightness, cold-dampness causing summer heat, abdominal pain and vomiting, diarrhea, nasal congestion and headache.

[0023] Dried ginger: The dried rhizome of *Zingiber officinale* Rosc., a plant in the ginger family (Zingiberaceae). Properties and Channels Entered: Pungent, hot. Enters the spleen, stomach, kidney, heart, and lung channels. Functions and Indications: Warms the middle jiao and dispels cold, restores yang and unblocks the channels, warms the lungs and resolves phlegm. Used for cold pain in the epigastrium and abdomen, vomiting and diarrhea, cold limbs and weak pulse, and cough with phlegm due to cold.

[0024] Eucommia: The dried bark of Eucommia ulmoides Oliv., a plant in the Eucommiaceae family. Properties and Channels Entered: Sweet, warm. Enters the Liver and Kidney channels. Functions and Indications: Tonifies the Liver and Kidneys, strengthens tendons and bones, and calms the fetus. Used for Liver and Kidney deficiency, lower back and knee pain, weakness of tendons and bones, dizziness, threatened miscarriage, and fetal restlessness.

[0025] Scutellaria baicalensis: The dried root of Scutellaria baicalensis georgi, a plant in the Lamiaceae family. Properties and Channels Entered: Bitter, cold. Enters the Lung, Gallbladder, Spleen, Large Intestine, and Small Intestine channels. Functions and Indications: Clears heat and dries dampness, drains fire and detoxifies, stops bleeding, and calms the fetus. Used for damp-heat syndrome, summer-heat syndrome, chest tightness and nausea, damp-heat fullness, diarrhea, jaundice, cough due to lung heat, high fever and thirst, hematemesis due to blood heat, carbuncles and boils, and threatened abortion.

[0026] Coptis chinensis: The dried rhizome of *Coptis chinensis* Franch., *Coptis deltoidea* CYChenget Hsiao, or *Coptis teeta* Wall., all belonging to the Ranunculaceae family. Properties and Channels Entered: Bitter, cold. Enters the Heart, Spleen, Stomach, Liver, Gallbladder, and Large Intestine channels. Functions and Indications: Clears heat and dries dampness, drains fire and detoxifies. Used for damp-heat fullness, vomiting and acid regurgitation, diarrhea, jaundice, high fever with delirium, excessive heart fire, restlessness and insomnia, palpitations, hematemesis due to blood heat, red eyes, toothache, diabetes, carbuncles and boils; externally used for eczema, damp sores, and ear discharge.

[0027] Job's tears (Coix lacryma-jobi var. mayuen): The dried, mature seed kernel of the grass Coix lacryma-jobi. Properties and Channels Entered: Sweet, bland, cool. Enters the Spleen, Stomach, and Lung channels. Functions and Indications: Promotes diuresis and eliminates dampness, strengthens the spleen and stops diarrhea, relieves numbness, drains pus, detoxifies and dissipates nodules. Used for edema, beriberi, dysuria, spleen deficiency diarrhea, dampness-induced numbness and contracture, lung abscess, intestinal abscess, warts, and tumors. Roasted Job's tears, while slightly cooling, are more neutral in nature and excel at strengthening the spleen and stopping diarrhea; they can be used for spleen deficiency diarrhea, poor appetite, and abdominal distension.

[0028] Prepared Pinellia: The dried tuber of Pinellia ternata (Thunb.) Breit., a plant in the Araceae family. Properties and Channels Entered: Pungent, warm. Enters the Spleen, Stomach, and Lung channels. Functions and Indications: Dries dampness and resolves phlegm. Used for cough with damp phlegm, epigastric fullness, and difficulty expectorating phlegm.

[0029] Dried tangerine peel: The dried, mature peel of Citrus reticulata Blanco and its cultivated varieties, belonging to the Rutaceae family. Properties and Channels Entered: Bitter, pungent, warm. Enters the Lung and Spleen channels. Functions and Indications: Regulates Qi and strengthens the Spleen, dries dampness and resolves phlegm. Used for abdominal distension, poor appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0030] Poria: The dried sclerotium of the fungus *Poria cocos* (Schw.) Wolf (family Polyporaceae). Properties and Channels Entered: Sweet, bland, neutral. Enters the Heart, Lung, Spleen, and Kidney channels. Functions and Indications: Promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. Used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0031] Atractylodes macrocephala: The dried rhizome of Atractylodes macrocephala Koidz., a plant in the Asteraceae family. Stir-fried Atractylodes macrocephala is prepared by sprinkling honey-roasted wheat bran into a hot pan, adding slices of Atractylodes macrocephala when it smokes, stir-frying until golden brown and releasing a caramelized aroma, then removing and sifting out the honey-roasted wheat bran. Properties and Channels Entered: Sweet and bitter, warm. Enters the Spleen and Stomach channels. Functions and Indications: Strengthens the spleen and replenishes qi, dries dampness and promotes diuresis, stops sweating, and calms the fetus. Used for spleen deficiency with poor appetite, abdominal distension and diarrhea, phlegm retention with dizziness and palpitations, edema, spontaneous sweating, and threatened abortion.

[0032] Corydalis rhizome (Yuanhu): The dried tuber of Corydalis yanhusuo WT. Wang, a plant in the Papaveraceae family. Vinegar-processed Corydalis rhizome is obtained by stir-frying cleaned Corydalis rhizome according to the vinegar-processing method (General Rule 0213) until dry, or by boiling it according to the vinegar-boiling method (General Rule 0213) until the vinegar is absorbed, then slicing it into thick slices or crushing it before use. Properties and Channels Entered: Pungent, bitter, warm. Enters the Liver and Spleen channels. Functions and Indications: Activates blood circulation, promotes qi circulation, and relieves pain. Used for chest and rib pain, abdominal pain, angina pectoris, amenorrhea, dysmenorrhea, postpartum blood stasis, and traumatic swelling and pain.

[0033] Bupleurum: The dried root of Bupleurum chinense DC. or Bupleurum corzonerifolium Willd., both belonging to the Apiaceae family. Vinegar-processed Bupleurum is obtained by stir-frying Bupleurum slices according to the vinegar-processing method (General Rule 0213). Properties and Channels Entered: Pungent, bitter, slightly cold. Enters the Liver, Gallbladder, and Lung channels. Functions and Indications: Disperses and reduces fever, soothes the liver and relieves stagnation, raises Yang Qi. Used for colds with fever, alternating chills and fever, chest and rib pain, irregular menstruation, uterine prolapse, and rectal prolapse.

[0034] Areca peel: The dried pericarp of the areca catechu L., a plant in the palm family (Arecaceae). Properties and Channels Entered: Pungent, slightly warm. Enters the spleen, stomach, large intestine, and small intestine channels. Functions and Indications: Regulates qi and relieves abdominal distension, promotes diuresis and reduces swelling. Used for dampness obstructing qi, abdominal distension, incomplete bowel movements, edema, beriberi with swelling, and difficulty urinating.

[0035] Chuanxiong (Ligusticum chuanxiong Hort.): The dried rhizome of the plant Ligusticum chuanxiong Hort. (Apiaceae family). Properties and Channels Entered: Pungent, warm. Enters the Liver, Gallbladder, and Pericardium channels. Functions and Indications: Activates blood circulation and promotes qi flow, dispels wind and relieves pain. Used for chest pain, stabbing pain in the chest and hypochondrium, traumatic swelling and pain, irregular menstruation, amenorrhea and dysmenorrhea, abdominal masses and pain, headache, and rheumatic pain.

[0036] Magnolia officinalis: The dried bark, root bark, and branch bark of Magnolia officinalis Rehd. et Wils. or Magnolia officinalis Rehd. et Wils. var. biloba Rehd. et Wils., belonging to the Magnoliaceae family. Properties and Channels Entered: Bitter, pungent, warm. Enters the Spleen, Stomach, Lung, and Large Intestine channels. Functions and Indications: Dries dampness and resolves phlegm, lowers qi and relieves fullness. Used for dampness stagnation in the middle jiao, epigastric fullness and vomiting / diarrhea, food stagnation and qi stagnation, abdominal distension and constipation, and phlegm-dampness cough and wheezing.

[0037] Hawthorn: The dried, ripe fruit of *Crataegus pinnatifida* Bge. var. major NE Br. or *Crataegus pinnatifida* Bge., both belonging to the Rosaceae family. For stir-frying hawthorn, use cleaned hawthorn berries and stir-fry according to the stir-frying method (General Rule 0213) until the color deepens. Properties and Channels Entered: Sour, sweet, slightly warm. Enters the Spleen, Stomach, and Liver channels. Functions and Indications: Promotes digestion and strengthens the stomach, regulates qi and disperses blood stasis, clears turbidity and lowers lipids. Used for food stagnation due to meat consumption, abdominal distension, diarrhea and abdominal pain, amenorrhea due to blood stasis, postpartum blood stasis, stabbing pain in the heart and abdomen, chest pain, hernia pain, and hyperlipidemia. Roasted hawthorn has enhanced digestive and stagnation-relieving effects. Used for food stagnation due to meat consumption and incomplete diarrhea.

[0038] Platycodon grandiflorum (Jacq.) A.DC., a plant in the Campanulaceae family. Properties and Channels Entered: Bitter, pungent, neutral. Enters the Lung channel. Functions and Indications: Clears the lungs, soothes the throat, eliminates phlegm, and drains pus. Used for cough with excessive phlegm, chest tightness, sore throat and hoarseness, and lung abscess with purulent sputum.

[0039] Prepared licorice root: A processed product of licorice (the dried root and rhizome of *Glycyrrhiza uralensis* Fisch., *Glycyrrhiza inflata* Bat., or *Glycyrrhiza glabra* L., all belonging to the Fabaceae family). Properties and Channels Entered: Sweet, neutral. Enters the Heart, Lung, Spleen, and Stomach channels. Functions and Indications: Tonifies the Spleen and Stomach, replenishes Qi and restores pulse. Used for weakness of the Spleen and Stomach, fatigue, palpitations, and irregular pulse.

[0040] It should also be noted that the method of using the water pills prepared in this invention is as follows: 3-5g (13-17 pills) per dose (the specific dosage is determined according to the severity of the condition), twice a day.

[0041] The present invention has the following beneficial effects:

[0042] The principal herbs in the traditional Chinese medicine composition provided by this invention are patchouli, dried ginger, and eucommia. Patchouli is aromatic and clears away turbidity, promoting the upward movement of clear qi and the downward movement of turbid qi; dried ginger warms the spleen yang; and eucommia warms and tonifies the kidney yang, addressing the root cause of the disease. The assistant herbs are coptis and scutellaria, which are bitter and cold, clearing away damp heat; coix seed clears damp heat and strengthens the spleen; pinellia and tangerine peel dry dampness and resolve phlegm, regulate qi and strengthen the spleen; poria and atractylodes macrocephala strengthen the spleen and resolve dampness; bupleurum, corydalis, areca peel, magnolia bark, and hawthorn regulate qi, relieve chest congestion, promote digestion, relieve stagnation, and alleviate pain. The addition of chuanxiong enhances the qi-regulating and blood-activating effects, raising the qi in the blood. The adjuvant and guiding herbs are prepared licorice root, which harmonizes the herbs, tonifies the spleen and stomach, and platycodon root, which opens and disperses lung qi, achieving the effect of promoting upward and downward flow of qi. All the herbs work together to treat both the root cause and the symptoms, warming and tonifying the spleen and kidney yang, clearing damp heat in the middle jiao, relieving bloating and resolving dampness, and promoting upward and downward flow of qi. Detailed Implementation

[0043] To enable those skilled in the art to better understand the present invention, the technical solution of the present invention will be described in further detail below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of the present invention.

[0044] It should be noted that, unless otherwise specified, the embodiments and features described in the present invention can be combined with each other. The present invention will now be described in detail with reference to the embodiments.

[0045] Example 1:

[0046] A method for preparing a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type includes the following steps:

[0047] S1. Weigh out each of the following raw medicinal materials according to the following weight proportions: 5 parts of patchouli, 10 parts of dried ginger, 10 parts of eucommia bark, 6 parts of scutellaria barbata, 3 parts of coptis chinensis, 20 parts of stir-fried coix seed, 10 parts of processed pinellia ternata, 10 parts of tangerine peel, 15 parts of poria cocos, 10 parts of stir-fried atractylodes macrocephala, 10 parts of vinegar-processed corydalis yanhusuo, 10 parts of vinegar-processed bupleurum chinense, 10 parts of areca peel, 10 parts of chuanxiong rhizome, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn fruit, 5 parts of platycodon grandiflorus, and 10 parts of prepared licorice root. Mix them together, wash and dry them. 1 part by weight = 100g.

[0048] S2. Crush the cleaned and dried raw medicinal materials into powder, pass them through a 100-mesh sieve to obtain medicinal powder, and control the sieve passing rate to ≥95%;

[0049] S3. Add 5.2L of water to the powder and stir thoroughly for 20 minutes. Then, make several pills and dry them in a vacuum drying oven at 45℃ to obtain Chinese herbal water pills for treating abdominal distension and diarrhea caused by a mixture of cold and heat.

[0050] Example 2:

[0051] A method for preparing a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type includes the following steps:

[0052] S1. Weigh out each of the following raw medicinal materials according to the following weight proportions: 3 parts of patchouli, 3 parts of dried ginger, 3 parts of eucommia bark, 3 parts of scutellaria barbata, 2 parts of coptis chinensis, 10 parts of stir-fried coix seed, 6 parts of processed pinellia ternata, 3 parts of tangerine peel, 10 parts of poria cocos, 6 parts of stir-fried atractylodes macrocephala, 6 parts of vinegar-processed corydalis yanhusuo, 6 parts of vinegar-processed bupleurum chinense, 6 parts of areca peel, 6 parts of chuanxiong rhizome, 6 parts of magnolia bark, 6 parts of stir-fried hawthorn, 3 parts of platycodon grandiflorus, and 3 parts of prepared licorice root. Mix them together, wash and dry them. 1 part by weight = 100g.

[0053] S2. Crush the cleaned and dried raw medicinal materials into powder, pass them through a 100-mesh sieve to obtain medicinal powder, and control the sieve passing rate to ≥95%;

[0054] S3. Add 3L of water to the powder and stir thoroughly for 30 minutes. Make several pills and dry them in a vacuum drying oven at 40℃ to obtain Chinese herbal water pills for treating abdominal distension and diarrhea caused by a mixture of cold and heat.

[0055] Example 3:

[0056] A method for preparing a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type includes the following steps:

[0057] S1. Weigh out each of the following raw medicinal materials according to the following weight proportions: 6 parts of patchouli, 10 parts of dried ginger, 12 parts of eucommia bark, 10 parts of scutellaria barbata, 6 parts of coptis chinensis, 20 parts of stir-fried coix seed, 10 parts of processed pinellia ternata, 10 parts of tangerine peel, 15 parts of poria cocos, 10 parts of stir-fried atractylodes macrocephala, 10 parts of vinegar-processed corydalis yanhusuo, 10 parts of vinegar-processed bupleurum chinense, 10 parts of areca peel, 10 parts of chuanxiong rhizome, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn fruit, 6 parts of platycodon grandiflorus, and 10 parts of prepared licorice root. Mix them together, wash and dry them. 1 part by weight = 100g.

[0058] S2. Crush the cleaned and dried raw medicinal materials into powder, pass them through a 100-mesh sieve to obtain medicinal powder, and control the sieve passing rate to ≥95%;

[0059] S3. Add 5.5L of water to the powder and stir thoroughly for 25 minutes. Then, make several pills and dry them in a vacuum drying oven at 42℃ to obtain Chinese herbal water pills for treating abdominal distension and diarrhea caused by a mixture of cold and heat.

[0060] Example 4:

[0061] A method for preparing a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type includes the following steps:

[0062] S1. Weigh out each of the following raw medicinal materials according to the following weight proportions: 4 parts of patchouli, 6 parts of dried ginger, 8 parts of eucommia bark, 5 parts of scutellaria barbata, 3 parts of coptis chinensis, 15 parts of stir-fried coix seed, 7 parts of processed pinellia ternata, 5 parts of tangerine peel, 12 parts of poria cocos, 8 parts of stir-fried atractylodes macrocephala, 8 parts of vinegar-processed corydalis yanhusuo, 8 parts of vinegar-processed bupleurum chinense, 8 parts of areca peel, 8 parts of chuanxiong rhizome, 8 parts of magnolia bark, 8 parts of stir-fried hawthorn, 4 parts of platycodon grandiflorus, and 6 parts of prepared licorice root. Mix them together, wash and dry them. 1 part by weight = 100g.

[0063] S2. Crush the cleaned and dried raw medicinal materials into powder, pass them through a 100-mesh sieve to obtain medicinal powder, and control the sieve passing rate to ≥95%;

[0064] S3. Add 4L of water to the powder and stir thoroughly for 30 minutes. Make several pills and dry them in a vacuum drying oven at 45℃ to obtain Chinese herbal water pills for treating abdominal distension and diarrhea caused by a mixture of cold and heat.

[0065] Example 5:

[0066] A method for preparing a traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type includes the following steps:

[0067] S1. Weigh out each of the following raw medicinal materials according to the following weight proportions: 5 parts of patchouli, 8 parts of dried ginger, 10 parts of eucommia bark, 8 parts of scutellaria barbata, 4 parts of coptis chinensis, 18 parts of stir-fried coix seed, 8 parts of processed pinellia ternata, 8 parts of tangerine peel, 15 parts of poria cocos, 10 parts of stir-fried atractylodes macrocephala, 10 parts of vinegar-processed corydalis yanhusuo, 10 parts of vinegar-processed bupleurum chinense, 10 parts of areca peel, 10 parts of chuanxiong rhizome, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn fruit, 5 parts of platycodon grandiflorus, and 8 parts of prepared licorice root. Mix them together, wash and dry them. 1 part by weight = 100g.

[0068] S2. Crush the cleaned and dried raw medicinal materials into powder, pass them through a 100-mesh sieve to obtain medicinal powder, and control the sieve passing rate to ≥95%;

[0069] S3. Add 5L of water to the powder and stir thoroughly for 20 minutes. Make several pills and dry them in a vacuum drying oven at 40℃ to obtain Chinese herbal water pills for treating abdominal distension and diarrhea caused by a mixture of cold and heat.

[0070] The instruments and methods involved in Examples 1-5 are commonly used equipment and methods in the field of traditional Chinese medicine preparations.

[0071] Clinical trial case:

[0072] To demonstrate the positive effect of the herbal pills prepared from the herbal composition of this invention on treating abdominal distension and diarrhea of ​​mixed cold and heat patterns, the inventors conducted clinical trials on patients with this condition using the herbal pills prepared in Example 1. A selection of clinical trial reports are presented below:

[0073] 1. Mr. Leng, male, 36 years old, chief complaint: loose stools, 3 to 5 times a day, abdominal distension and discomfort, halitosis for many years; accompanied by cold lower limbs, dark red tongue, yellow and greasy tongue coating, soft pulse, and strong liver pulse. Diagnosis: diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0074] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0075] 2. Ms. Guo, 57 years old. Chief complaint: Long-term abdominal distension and loose stools; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0076] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0077] 3. Liu XX, male, 63 years old. Chief complaint: Abdominal distension, loose stools for many years, bad breath; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0078] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0079] 4. Zhang XX, male, 69 years old. Chief complaint: Abdominal distension for many years, accompanied by diarrhea, 2-3 times a day; dark red tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat); diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0080] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue was normal, coating was thin and white, and pulse was heavy but stronger than before.

[0081] 5. Zhang XX, male, 72 years old. Chief complaint: Abdominal distension for many years, accompanied by loose stools when emotional changes occur, sometimes four or five times a day, with mild abdominal pain; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0082] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0083] 6. Ms. Guo, 48 years old. Chief complaint: Abdominal distension for three months, accompanied by sometimes loose stools, two to three times a day, and sometimes incomplete bowel movements, once every two days, with a heavy, foul odor. Tongue: pale and dark, with a thin, yellow, greasy coating. Pulse: deep and weak. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication: 12 pills after breakfast and dinner for half a month.

[0084] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0085] 7. Zhang XX, male, 53 years old. Chief complaint: Abdominal distension for many years, aggravated by alcohol consumption, accompanied by diarrhea and bitter taste in the mouth; dark red tongue with a thin, yellow, greasy coating, and a deep, weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0086] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue body was normal, tongue darkness was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0087] 8. Mr. Dong, male, 68 years old. Chief complaint: abdominal distension, cold limbs, stomach upset, loose stools (two to three times a day), accompanied by halitosis; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0088] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0089] 9. Zhang XX, male, 58 years old. Chief complaint: Abdominal distension for many years, fever in the afternoon, chills in the evening, diarrhea three to four times a day; dark red tongue with thin yellow greasy coating, deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0090] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue was dark and normal, coating was thin and white, pulse was heavy and stronger than before.

[0091] 10. Cao XX, male, 57 years old. Chief complaint: loose stools and abdominal distension for many years, bitter taste in mouth; pale and dark tongue with a thin, yellow, greasy coating, deep and weak pulse. Diagnosis: diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0092] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0093] 11. Ms. Lin, 32 years old. Chief complaint: Loose stools, three to four times daily, cold limbs, accompanied by abdominal distension, sticky mouth, pale, swollen, dark tongue with a white, greasy, slightly yellow coating, deep and weak pulse, especially at the cun position. Diagnosis: Diarrhea (mixed cold and heat syndrome). Medication for half a month: 12 pills after breakfast and dinner.

[0094] Follow-up visit: Stool formed, once a day, abdominal distension, sticky feeling in the mouth, reduced coldness in the lower limbs, pale and dark tongue with thin white coating, deep and weak pulse at the cun position.

[0095] 12. Li XX, male, 46 years old. Chief complaint: abdominal distension, bad breath, and incomplete bowel movements; dark red tongue with a thin, yellow, greasy coating, and a deep, weak pulse. Diagnosis: abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0096] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue was normal, coating was thin and white, and pulse was heavy but stronger than before.

[0097] 13. Wang XX, male, 59 years old. Chief complaint: Abdominal distension for many years, diarrhea after getting angry, pale and dark tongue with a thin, yellow, greasy coating, and a deep, weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 12 pills after breakfast and dinner.

[0098] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0099] 14. Chen XX, male, 66 years old. Chief complaint: Long-term abdominal distension, accompanied by loose stools, two to three times a day, and sometimes difficulty in defecation; once every two days, with a heavy and pungent odor; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat), diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0100] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0101] 15. Wu XX, male, 46 years old. Chief complaint: loose stools, 5-6 bowel movements per day, abdominal distension for many years, sticky and bitter taste in the mouth; pale and dark tongue with a thin, yellow, greasy coating, deep and weak pulse. Diagnosis: diarrhea (mixed cold and heat), abdominal distension (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0102] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, tongue darkening was reduced, tongue coating was thin and white, and pulse was heavy and stronger than before.

[0103] 16. Lin X, male, 58 years old. Chief complaint: Long-term abdominal distension, loose stools 3-4 times a day, resulting in poor sleep; hot palms; pale and dark tongue with a thin, yellow, greasy coating; deep and weak pulse. Diagnosis: Abdominal distension (mixed cold and heat); diarrhea (mixed cold and heat). Medication for half a month: 15 pills after breakfast and dinner.

[0104] Follow-up visit: Abdominal distension disappeared, bowel movements were normal, sleep improved, tongue darkening lessened, tongue coating thinned to white, and pulse became heavier and stronger than before.

[0105] 17. Ms. Liu, 30 years old. Chief complaint: Loose stools for five or six years, worsened by consuming cold drinks, spicy or greasy foods, sometimes five to seven times a day. Accompanying symptoms include epigastric discomfort, abdominal distension, acid reflux, cold hands and feet, and infrequent menstruation. Tongue is large, pale and dark, with a white, greasy, slightly yellow coating. Pulse is deep and weak, especially at the cun position. Diagnosis: Diarrhea (mixed cold and heat syndrome), abdominal distension (mixed cold and heat syndrome). Prescription: 15 pills twice daily, morning and evening, after meals, for half a month.

[0106] Follow-up visit: Loose stools disappeared, bowel movements occurred once a day, formed stools, stomach discomfort and acid reflux disappeared, no abdominal distension, cold hands and feet were relieved, menstruation resumed, tongue was slightly swollen, dark in color and formed, thin white coating, deep and weak pulse at the cun position.

[0107] In summary, the traditional Chinese medicine composition of the present invention and the traditional Chinese medicine pills prepared using the above-mentioned traditional Chinese medicine composition have significant effects in treating abdominal distension and diarrhea of ​​mixed cold and heat type.

[0108] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type, characterized in that, The traditional Chinese medicine composition consists of the following raw medicinal materials in parts by weight: 3-6 parts of patchouli, 3-10 parts of dried ginger, 3-12 parts of eucommia bark, 3-10 parts of scutellaria barbata, 2-6 parts of coptis chinensis, 10-20 parts of stir-fried coix seed, 6-10 parts of processed pinellia ternata, 3-10 parts of tangerine peel, 10-15 parts of poria cocos, 6-10 parts of stir-fried atractylodes macrocephala, 6-10 parts of vinegar-processed corydalis yanhusuo, 6-10 parts of vinegar-processed bupleurum chinense, 6-10 parts of areca peel, 6-10 parts of chuanxiong rhizome, 6-10 parts of magnolia bark, 6-10 parts of stir-fried hawthorn fruit, 3-6 parts of platycodon grandiflorus, and 3-10 parts of prepared licorice root.

2. The traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following raw medicinal materials in parts by weight: 4-5 parts of patchouli, 6-8 parts of dried ginger, 8-10 parts of eucommia bark, 5-8 parts of scutellaria baicalensis, 3-4 parts of coptis chinensis, 15-18 parts of stir-fried coix seed, 7-8 parts of processed pinellia ternata, 5-8 parts of tangerine peel, 12-15 parts of poria cocos, 8-10 parts of stir-fried atractylodes macrocephala, 8-10 parts of vinegar-processed corydalis yanhusuo, 8-10 parts of vinegar-processed bupleurum chinense, 8-10 parts of areca peel, 8-10 parts of chuanxiong rhizome, 8-10 parts of magnolia bark, 8-10 parts of stir-fried hawthorn fruit, 4-5 parts of platycodon grandiflorus, and 6-8 parts of prepared licorice root.

3. The traditional Chinese medicine composition for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 1, characterized in that, The traditional Chinese medicine composition consists of the following raw medicinal materials in parts by weight: 5 parts of patchouli, 10 parts of dried ginger, 10 parts of eucommia bark, 6 parts of scutellaria baicalensis, 3 parts of coptis chinensis, 20 parts of stir-fried coix seed, 10 parts of processed pinellia ternata, 10 parts of tangerine peel, 15 parts of poria cocos, 10 parts of stir-fried atractylodes macrocephala, 10 parts of vinegar-processed corydalis yanhusuo, 10 parts of vinegar-processed bupleurum chinense, 10 parts of areca peel, 10 parts of chuanxiong rhizome, 10 parts of magnolia bark, 10 parts of stir-fried hawthorn fruit, 5 parts of platycodon grandiflorus, and 10 parts of prepared licorice root.

4. A medicament for treating abdominal distension and diarrhea of ​​mixed cold and heat type, comprising the traditional Chinese medicine composition according to any one of claims 1-3, and further comprising pharmaceutically acceptable excipients.

5. The drug according to claim 4, characterized in that, The drug is an oral preparation.

6. The drug according to claim 4, characterized in that, The oral preparation may be a solid or liquid preparation.

7. The drug according to claim 6, characterized in that, The oral preparation is one of the following: pills, granules, capsules, tablets, powders, ointments, oral liquids, or decoctions.

8. A traditional Chinese medicine water pill for treating abdominal distension and diarrhea of ​​mixed cold and heat type, characterized in that, The herbal pills are prepared from the herbal composition described in any one of claims 1-3.

9. The method for preparing the traditional Chinese medicine water pills for treating abdominal distension and diarrhea of ​​mixed cold and heat type according to claim 8, characterized in that, Includes the following steps: S1. Weigh each raw medicinal material according to the weight proportions, mix them, and then wash and dry them. S2. After cleaning and drying, pulverize the raw medicinal materials and pass them through a 100-mesh sieve to obtain medicinal powder, controlling the sieve passing rate to ≥95%; S3. After adding water to the powder and stirring thoroughly for 20-30 minutes, make pills and dry them in a vacuum drying oven at 40-45℃ to obtain Chinese medicine water pills; The volume ratio of water to the total mass of the raw medicinal materials is 3:

10.

10. The use of the traditional Chinese medicine composition according to any one of claims 1-3 in the preparation of a medicament for treating abdominal distension and diarrhea of ​​mixed cold and heat type.