Oxygenation ventilation system

Abstract

The invention discloses an oxygenation ventilation system which comprises an oxygen generator, a gas oscillator, a ventilation catheter and a non-invasive breathing connector. The oxygen generator is communicated with the non-invasive breathing connector through a ventilation guide pipe, gas oscillators are arranged on a primary oxygen outlet channel of the oxygen generator and / or the non-invasive cover, and the gas oscillators are used independently or jointly, so that oxygen generated by the oxygen generator generates oscillation. The oxygenation ventilation system can effectively improve the oxygenation capacity of a patient and improve the oxygen saturation degree and the pulmonary alveolar ventilation function of the respiratory failure patient.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical respiration, and specifically relates to an oxygenation ventilation system. Background Art

[0002] In the medical field, for patients suffering from lung diseases or other diseases causing gas exchange disorders, maintaining sufficient oxygen saturation is a crucial link in the treatment process. Conventional oxygen generators deliver additional oxygen to patients through methods such as nasal catheters or masks. Their working principle is relatively basic, mainly based on increasing the oxygen concentration in the inhaled gas of patients in the hope of increasing oxygen saturation. However, this method has significant limitations.

[0003] When a patient has a gas exchange disorder, the problem often lies in the gas exchange link between the alveoli and the blood. For example, when the gas exchange barrier (including the alveolar surface liquid layer, type I alveolar cells and their basement membranes, thin connective tissue, capillary basement membranes, and endothelium) is diseased, normal gas exchange cannot occur. Even if the conventional oxygen generator increases the oxygen concentration of the inhaled gas, due to the substantial obstruction of gas exchange, oxygen is still difficult to effectively enter the blood from the alveoli, and thus the oxygen saturation of the patient cannot be significantly increased.

[0004] As an important device for improving ventilation and oxygenation, traditional ventilators also face many challenges in dealing with gas exchange disorders. Some ventilators attempt to maintain airway patency and improve ventilation through positive pressure ventilation. However, for severe gas exchange disorders, such as in patients with severe acute respiratory distress syndrome (ARDS), even when the oxygen concentration is increased to 80% or even 100%, and the inspiratory pressure is increased, the blood oxygen concentration is still difficult to increase, and ventilation is also difficult to proceed smoothly. This indicates that the severe impairment of the lung gas exchange function has exceeded the scope that the conventional functions of ventilators can handle.

[0005] Although an extracorporeal membrane oxygenator can draw blood from a patient's vein through intubation, use a machine (artificial lung) for oxygen supply, convert venous blood into arterial blood, and then transfuse it back into the human body, this device has many problems. On the one hand, after the blood contacts the artificial materials of the extracorporeal membrane oxygenator, it is easy to trigger the body's defense reaction and cause complications such as blood coagulation. Although the progress of coating technology has reduced the occurrence probability of blood coagulation complications, the risk still exists. On the other hand, the human body structure and physiological mechanism are extremely complex, and it is difficult for the extracorporeal membrane oxygenator to fully simulate the body's own cardiopulmonary function. Data from the Extracorporeal Life Support Organization shows that its overall treatment success rate is only about 50%, and the device has a high cost and complex operation, making it difficult to be widely popularized and applied in daily medical scenarios.

[0006] Currently, whether it is a conventional oxygen generator or a traditional ventilation device, when faced with patients with gas exchange disorders, it is difficult to effectively increase the oxygen saturation of the patients and meet the needs of clinical treatment. There is an urgent need for a new oxygenation ventilation system to solve this problem. Summary of the Invention

[0007] In view of the deficiencies of the prior art, the purpose of the present invention is to provide an oxygenation ventilation system to solve the technical problem that the existing oxygen generators are difficult to increase the oxygen saturation of patients with gas exchange disorders mentioned in the above background technology.

[0008] To achieve the aforementioned invention purpose, the technical solutions adopted by the present invention include: An oxygenation ventilation system includes an oxygen generator, a gas oscillator, a ventilation catheter, and a non-invasive breathing interface; the oxygen generator is connected to the non-invasive breathing interface through the ventilation catheter, and the gas oscillator is provided on the primary oxygen outlet path of the oxygen generator or on the non-invasive mask, and the gas oscillator can cause the oxygen produced by the oxygen generator to oscillate.

[0009] Further, the gas oscillator includes a primary oscillator and a terminal oscillator. The primary oscillator is provided on the oxygen generator, and the terminal oscillator is provided on the non-invasive breathing interface. After the oxygen oscillates in the primary oscillator, it resonates at the non-invasive breathing interface under the action of the terminal oscillator.

[0010] Further, the non-invasive breathing interface is a non-invasive breathing mask, a non-invasive breathing nasal mask, or a non-invasive breathing nasal plug.

[0011] Further, the terminal oscillator is a thin film oscillator.

[0012] Further, the thin film oscillator is piezoelectrically driven.

[0013] Further, the thin film oscillator is photosensitively driven.

[0014] Further, the wave generated by resonance is a periodic waveform.

[0015] Further, the wave generated by resonance is a sine wave or a square wave.

[0016] Further, the oscillation frequency generated by resonance ≤ 100 Hz, and the amplitude ≤ 10 cmH₂O.

[0017] Compared with the prior art, the advantages of the present invention include: (1) In this application, an oxygen generator is used to oscillate the oxygen produced by the oxygen generator. The oscillating oxygen enters the human body along the ventilation duct and the non-invasive breathing interface. After the oxygen with amplitude reaches the human lungs, it drives the alveoli to expand through its vibration, thereby partially restoring the gas exchange function of the alveoli and enabling it to better perform oxygenation and alveolar ventilation functions. Compared with existing oxygen generators, it restores the expansion of the alveoli through vibration, promotes gas exchange, and for patients with gas exchange disorders such as hypoxemia, pneumoconiosis, and respiratory failure, it can well improve the problem of low blood oxygen saturation and quickly increase the patient's blood oxygen saturation to an ideal level.

[0018] (2) The primary oscillator and the terminal oscillator are used to resonate and amplify the amplitude of oxygen within the non-invasive breathing interface. Compared with existing high-frequency oscillatory ventilation, in order to cope with the attenuation of gas amplitude within the ventilation duct, high-frequency oscillatory ventilation needs to be inserted into the human airway, while this system achieves high-frequency low tidal volume ventilation in a non-invasive resonant oscillation manner, reducing barotrauma; compared with existing non-invasive positive pressure ventilation, it can eliminate a series of problems with poor compliance such as headache and flatulence caused by positive pressure. Description of the Drawings

[0019] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings described below are only some embodiments recorded in the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0020] Figure 1 It is a schematic diagram of the overall oxygenation ventilation system in the present invention; Figure 2 It is a schematic diagram of another angle of the oxygenation ventilation system in the present invention.

[0021] Reference Signs: Oxygen generator 1, primary oscillator 21, terminal oscillator 22, oscillation film 221, oscillation generator 222, ventilation duct 3, non-invasive breathing interface 4. Detailed Embodiments

[0022] In view of the deficiencies in the prior art, the inventors of this case have proposed the technical solution of the present invention through long-term research and a large number of practices. The following will further explain and illustrate the technical solution, its implementation process, and principles in combination with the drawings in the embodiments of the present application and specific implementation cases.

[0023] It should be noted that the embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as a limitation of the present invention. The described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, the present invention covers any substitutions, modifications, equivalent methods and solutions made within the spirit, principle and scope of the present invention defined by the claims. All other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the scope of protection of the present invention.

[0024] In the description of the present application, terms such as "first", "second", "third" and similar terms do not denote any order, quantity or importance, but are only used to distinguish different components. Similarly, terms such as "a" or "one" do not denote a quantity limitation, but indicate that there is at least one. Terms such as "comprising" or "including" mean that the elements or items appearing before "comprising" or "including" cover the elements or items listed after "comprising" or "including" and their equivalents, and do not exclude other elements or items. Terms such as "connected" or "coupled" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect.

[0025] In the description of the present application, the orientation or positional relationship indicated by terms such as "center", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present application. In addition, when using position terms such as both sides, outer side, upper and lower, etc., it should be understood that they are only used for convenience of understanding and description, considering that the structure may be oriented to other positions.

[0026] In the description of the present application, unless otherwise clearly defined and limited, the technical terms or scientific terms used should have the ordinary meaning understood by those of ordinary skill in the art to which the present application pertains. Terms such as "installed", "connected", "coupled" should be understood in a broad sense. For example, they may be fixedly connected, detachably connected, or in contact connection or integral connection; for those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific circumstances.

[0027] Embodiments of the present invention aim to introduce and illustrate the structural composition of the oxygenation ventilation system and the cooperation relationship between its various component structures. Unless otherwise specified, the dimensions, materials, manufacturing processes, etc. of the components suitable for the oxygenation ventilation system in the embodiments of the present invention can be selected according to specific circumstances, and no special limitations and explanations are made here.

[0028] Furthermore, in order to enable the public to have a better understanding of the present invention, in the following detailed description of the present invention, some specific details are described in detail. Those skilled in the art can fully understand the present invention without the description of these details.

[0029] Please refer to Figure 1 and Figure 2 , this embodiment provides an oxygenation ventilation system, including an oxygen generator 1, a gas oscillator, a ventilation duct 3, and a non-invasive breathing interface 4; the oxygen generator 1 is connected to the non-invasive breathing interface through the ventilation duct 3, and a gas oscillator is provided on the primary oxygen outlet path of the oxygen generator 1 or on the non-invasive mask, and the gas oscillator can make the oxygen generated by the oxygen generator 1 oscillate. Specifically, the gas oscillator is either the primary oscillator 21 provided at the air outlet of the oxygen generator 1 or the end oscillator 22 provided at the non-invasive breathing interface 4, and its specific size and shape are adjusted accordingly according to its installation position. The ventilation duct 3 is made of a low-damping material, such as a silicone rubber or fluororubber catheter.

[0030] In this application, the gas oscillator makes the oxygen generated by the oxygen generator 1 oscillate, and the oscillating oxygen enters the human body along the ventilation duct 3 and the non-invasive breathing interface 4. The oxygen with amplitude drives the alveoli to expand through its vibration after reaching the human lungs, thereby partially restoring the gas exchange function of the alveoli and enabling it to better perform oxygenation and alveolar ventilation functions. Compared with the existing oxygen generator 1, it restores the expansion of the alveoli through vibration to promote gas exchange. For patients with gas exchange disorders such as hypoxemia, pneumoconiosis, and respiratory failure, it can well improve the problem of low blood oxygen saturation.

[0031] In other solutions, the gas oscillator includes a primary oscillator 21 and an end oscillator 22. The primary oscillator 21 is provided on the oxygen generator 1, and the end oscillator 22 is provided on the non-invasive breathing interface 4. After the oxygen oscillates in the primary oscillator 21, it undergoes high-frequency resonance by the end oscillator 22 when it reaches the non-invasive breathing interface 4. It should be understood that the high frequency generated by the resonance is the frequency referred to as "high frequency" in the field of respiratory ventilation, such as the high-frequency frequency mentioned in high-frequency oscillatory ventilation. Specifically in this application, the primary oscillator and the end oscillator generate high-frequency resonance through oscillation at a specific frequency, and the frequency is not higher than 100 Hz, preferably 5 - 25 Hz.

[0032] That is to say, under this solution, oscillators are provided at both the oxygen generator 1 end and the non-invasive breathing interface 4 end. The excitation frequency of the terminal oscillator 22 matches the frequency generated by oxygen in the primary oscillator 21, and the amplitude of oxygen resonantly amplifies within the non-invasive breathing interface 4. Generally, the ventilation catheter 3 is 1.5 meters or longer, and the amplitude generated within the oxygen primary oscillator 21 significantly attenuates after reaching the non-invasive breathing mask through the ventilation catheter 3. This solution compensates for the amplitude attenuation of oxygen within the ventilation catheter 3 by generating resonance at the non-invasive breathing interface 4 end to increase the amplitude of oxygen. Specifically, the primary oscillator 21 can use a piezoelectric-driven acoustic wave generator to directly control the frequency of the output acoustic wave by adjusting the frequency of the driving voltage, or it can use a pneumatic oscillator (such as the principle of a vortex flowmeter), and by adjusting the flow rate or the size of the obstacle, make the vortex shedding frequency match the resonance frequency of the thin film. Of course, it can also use a vibrator such as a tympanic membrane to vibrate the gas.

[0033] In other solutions, the non-invasive breathing interface 4 is a non-invasive breathing mask, a non-invasive breathing nasal mask, or a non-invasive breathing nasal plug. By setting different types of breathing masks, it can adapt to different populations.

[0034] In other solutions, the terminal oscillator 22 is a thin film oscillator. It should be understood that the thin film oscillator includes an oscillating thin film 221 and an oscillation generator 222, and the thin film body is made to oscillate through the oscillation generating mechanism, thereby exciting oxygen to generate harmonic resonance.

[0035] In other solutions, the thin film oscillator is piezoelectrically driven. That is, the oscillating thin film 221 is a piezoelectric thin film. Specifically, an alternating voltage is applied to the piezoelectric thin film by the oscillation generator 222, and periodic deformation is generated using the inverse piezoelectric effect, thereby generating vibration. The piezoelectric thin film can use aluminum nitride thin film, zinc oxide thin film, polyvinylidene fluoride thin film, lead zirconate titanate thin film, etc. Among them, the aluminum oxide thin film has the characteristics of high frequency and low loss; the zinc oxide thin film has the characteristic of low cost; the polyvinylidene fluoride thin film is a flexible piezoelectric polymer and can be preferably used. For relevant information on the vibration of piezoelectric thin films, specific reference can be made to the classic papers of Ruby et al. (e.g., "FBAR Filters for 5G Applications") or journals such as 《Journal of Microelectromechanical Systems》 and 《IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control》 that publish research on piezoelectric thin films and MEMS technology.

[0036] In other solutions, the thin film oscillator is photo-sensitively driven.

[0037] That is to say, the oscillating film 221 is a photosensitive film, which can be specifically a photothermal drive material or a photoinduced piezoelectric material. The oscillation generator 222 causes the photosensitive film to oscillate by applying light energy to the photosensitive film. When it is a photothermal drive material, the photosensitive film absorbs light energy → converts it into heat energy → thermal expansion / contraction causes vibration, so as to achieve the vibration of the gas. The photosensitive film can use carbon-based materials with high photothermal conversion efficiency and fast response, such as graphene and carbon nanotubes, or metal nanoparticle composites with enhanced light absorption by local surface plasmon resonance (LSPR). When it is a photoinduced piezoelectric material, photoinduced electron state change → lattice distortion → macroscopic deformation or vibration, so as to achieve the vibration of the gas. The photosensitive film can be selected from ferroelectric ceramics (such as PLZT lanthanum lead zirconate titanate) that require ultraviolet light excitation, or organic photoinduced piezoelectric polymers (such as azobenzene derivatives) that respond to visible light, etc.

[0038] In other solutions, the wave generated by resonance is a periodic waveform.

[0039] In other solutions, the wave generated by resonance is a sine wave or a square wave.

[0040] In other solutions, the oscillation frequency generated by resonance ≤ 100 Hz, and the amplitude ≤ 10 cm.

[0041] The above oxygenation ventilation system can effectively improve the oxygenation ability of patients, and improve the oxygen saturation and the alveolar gas exchange function of patients with respiratory failure.

[0042] It should be understood that the above embodiments are only used to illustrate the technical concept and characteristics of the present invention. The purpose is to enable those who are familiar with this technology to understand the content of the present invention and implement it accordingly. It cannot be determined that the specific implementation of the present invention is only limited to these descriptions. For those of ordinary skill in the technical field to which the present invention belongs, without departing from the concept of the present invention, several simple deductions or replacements can be made. All equivalent changes or modifications made according to the spirit of the present invention should be covered within the protection scope of the present invention.

Claims

1. An oxygenation ventilation system, characterized in that: It includes an oxygen concentrator, a gas oscillator, a ventilation catheter and a non-invasive breathing interface; the oxygen concentrator is connected to the non-invasive breathing interface through the ventilation catheter, and the gas oscillator is provided on the primary oxygen outlet passage of the oxygen concentrator or on the non-invasive cover, and the gas oscillator can make the oxygen produced by the oxygen concentrator oscillate.

2. An oxygenation and ventilation system according to claim 1, characterized in that: The gas oscillator includes a primary oscillator and a terminal oscillator. The primary oscillator is arranged on the oxygen concentrator, and the terminal oscillator is arranged on the non-invasive breathing interface. After the oxygen oscillates in the primary oscillator, it is subjected to high-frequency resonance by the terminal oscillator when it reaches the non-invasive breathing interface.

3. An oxygenation and ventilation system according to claim 1, characterized in that: The non-invasive breathing interface is a non-invasive breathing mask, a non-invasive breathing nasal mask or a non-invasive breathing nasal plug.

4. An oxygenation and ventilation system according to claim 2, characterized in that: The end oscillator is a thin film oscillator.

5. An oxygenation and ventilation system according to claim 4, characterized in that: The thin film oscillator is piezoelectrically driven.

6. An oxygenation and ventilation system according to claim 4, characterized in that: The thin film oscillator is photosensitively driven.

7. An oxygenation and ventilation system according to any one of claims 2 to 6, characterized in that: The waves produced by resonance are periodic waveforms.

8. An oxygenation and ventilation system according to claim 7, characterized in that: The waves produced by resonance are either sine waves or square waves.

9. An oxygenation and ventilation system according to any one of claims 2 to 6, characterized in that: The oscillation frequency generated by resonance is ≤100Hz, and the amplitude is ≤10cm water column.

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