Xanthophyll zeaxanthin soft capsule and production process thereof

Abstract

The invention relates to a lutein zeaxanthin soft capsule and a production process thereof, and belongs to the technical field of health care products. The xanthophyll and the zeaxanthin are used as main active components, and the DHA, the blueberry extract, the glutathione and the lactoferrin are used as auxiliary materials to synergistically enhance the eye protection effect of the capsule. The beeswax, the wheat germ oil and the active ingredients are mixed and homogenized by a high-pressure homogenizer, so that uniform dispersion of the ingredients is ensured, the absorption efficiency of the ingredients is enhanced, and the effect of the capsule is further improved through stability and release control of the active ingredients in wrapping of the active ingredients.

Description

Technical Field

[0001] The present invention belongs to the technical field of health products and relates to a lutein zeaxanthin soft capsule and its production process. Background Art

[0002] In recent years, with the widespread use of electronic devices and the change of modern lifestyle, visual fatigue and eye health problems have become increasingly serious. Long-term use of electronic devices such as computers and mobile phones can cause excessive eye fatigue, resulting in symptoms such as blurred vision, dryness, and eye pain, seriously affecting people's quality of life. Especially for teenagers and office workers, long-term close-range eye use increases the risk of visual fatigue and even myopia. In addition, with the growth of age, the natural aging process of the eyes will also lead to eye diseases such as macular degeneration and cataracts. Therefore, protecting eye health and preventing and relieving visual fatigue have become an important public health issue.

[0003] Lutein and zeaxanthin are two important carotenoids, which are widely present in green vegetables, corn, and egg yolks. They are mainly concentrated in the retina and macula area of the human body and play an important role in eye health. Lutein and zeaxanthin can absorb blue light, reduce the damage of blue light to the retina, and have antioxidant effects, protecting the eyes from free radical damage. In addition, wheat germ oil is rich in vitamin E and essential fatty acids, which can enhance the stability of cell membranes, promote blood circulation in the eyes, and slow down the eye aging process. Beeswax, as a natural thickener and stabilizer, can not only improve the stability of the capsule but also has a certain antibacterial effect.

[0004] Although there are many lutein zeaxanthin products on the market at present, there are still some deficiencies. First, the stability of lutein and zeaxanthin is poor, and they are easily degraded during production and storage, affecting the effectiveness of the products. Second, the fat solubility of these components is relatively strong, and the oral absorption efficiency is low simply by relying on it, making it difficult to fully exert their eye protection effects. Nano-dispersion can be used to improve the stability and bioavailability of active ingredients, thereby enhancing the eye protection effect of the products. Summary of the Invention

[0005] The present invention relates to a lutein zeaxanthin soft capsule and its production process, belonging to the technical field of health products. The present invention uses lutein and zeaxanthin as the main active ingredients, supplemented by DHA, blueberry extract, glutathione, and lactoferrin to synergistically enhance the eye protection effect of the capsule. By mixing beeswax, wheat germ oil with the active ingredients and using a high-pressure homogenizer for homogenization treatment, the uniform dispersion of the ingredients is ensured, enhancing their absorption efficiency, and controlling the stability and release of the active ingredients by encapsulating the active ingredients, further improving the effect of the capsule.

[0006] The object of the present invention can be achieved by the following technical solutions:

[0007] A lutein and zeaxanthin soft capsule, the capsule core contains lutein, zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and is homogenized and encapsulated after being mixed with beeswax and wheat germ oil. The mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione and lactoferrin is 1:0.1 - 0.3:20 - 28:4 - 8:1.5 - 2.5:1.5 - 2.5:1.5 - 2.5:0.6 - 1; the capsule shell contains glycerol, deionized water, titanium dioxide, caramel color, carmine, sunset yellow, gelatin, and the mass ratio is 1:1.5 - 2.5:0.01 - 0.02:0.004 - 0.008:0.002 - 0.004:0.002 - 0.004:0.002 - 0.004:0.2 - 0.4.

[0008] Furthermore, the production process of the above-mentioned lutein and zeaxanthin soft capsule includes the following steps:

[0009] (1) Heat and melt beeswax and wheat germ oil until it becomes clear and transparent to obtain an oil-wax mixture.

[0010] (2) Stir and heat wheat germ oil to 50 - 60 °C, add the oil-wax mixture, stir for 1 - 3 min, cool to 30 - 35 °C, add lutein, pretreated zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and continue to stir for 15 - 25 min to obtain an active mixture.

[0011] (3) Homogenize the active mixture through a high-pressure homogenizer at a pressure of 50 - 80 MPa and a temperature of 20 - 40 °C to obtain nano-active ingredients, and then encapsulate the nano-active ingredients to obtain the capsule core material.

[0012] (4) Mix titanium dioxide and deionized water evenly and pass through a 200-mesh sieve to obtain a titanium dioxide suspension.

[0013] (5) Mix sunset yellow, carmine, caramel color and deionized water evenly to obtain a pigment.

[0014] (6) Mix deionized water and glycerol evenly, add the titanium dioxide suspension and the pigment and stir evenly, heat to 65 - 75 °C, add gelatin, continue to heat to 70 - 80 °C, stir until the gelatin is completely dissolved, remove air bubbles under vacuum and then let it stand to obtain the capsule shell material.

[0015] (7) Use a soft capsule pill press to make the capsule core material and the capsule shell material into capsules with a specification of 400 mg / capsule, and obtain the lutein and zeaxanthin soft capsules through shaping and drying.

[0016] As a preferred technical solution of the present invention, the mass ratio of the wheat germ oil in steps (1) and (2) is 1:1.

[0017] As a preferred technical solution of the present invention, the pretreatment of zeaxanthin in step (2) is to heat and stir evenly in a water bath at 50 - 60°C.

[0018] As a preferred technical solution of the present invention, the encapsulation treatment steps in step (3) are as follows: Add maltodextrin, lactose, gelatin, and sodium alginate to deionized water, stir evenly, then add nano-active ingredients and mix evenly, and then perform spray drying through a spray dryer; the mass ratio of maltodextrin, lactose, gelatin, sodium alginate, deionized water, and nano-active ingredients is 4 - 6:2 - 3:1 - 3:0.05 - 0.1:10 - 15:8 - 10.

[0019] As a preferred technical solution of the present invention, the mass ratio of deionized water in steps (4), (5), and (6) is 1:1:8.

[0020] As a preferred technical solution of the present invention, the viscosity of the capsule shell material in step (6) is 20000 - 35000 mPa·s, and the material discharging process of the capsule shell material is filtered through a 100 - mesh filter bag; the static temperature is 55 - 70°C, and the time is 2 - 24 h.

[0021] As a preferred technical solution of the present invention, the shaping in step (7) is to send the capsules into a rotating cage for shaping for 2 - 4 h, the temperature is 18 - 26°C, and the relative humidity ≤ 40%; the drying is to place the shaped soft capsules on a drying tray, keep the temperature at 20 - 30°C, and perform drying for 16 - 24 h.

[0022] Advantages of the present invention:

[0023] (1) The present invention uses lutein and zeaxanthin as the main active ingredients, combines multiple auxiliary ingredients such as DHA, blueberry extract, glutathione, and lactoferrin, and optimizes the proportion of each ingredient, improving the stability and bioavailability of lutein and zeaxanthin, thereby enhancing the eye - protecting effect of the product.

[0024] (2) The present invention heats and melts beeswax and wheat germ oil, and then mixes them with the active ingredients, ensuring the full and uniform fusion of the materials. After homogenization treatment using a high - pressure homogenizer and then encapsulation treatment, the capsule core material is more stable, the active ingredients are slowly released, and the bioavailability is improved. Specific embodiments

[0025] To further elaborate on the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the following combines examples to detail the specific embodiments, structures, features, and their effects according to the present invention.

[0026] In the following examples and comparative examples, lutein was purchased from Shanghai Yuanye Bio-Technology Co., Ltd.; zeaxanthin was purchased from Xi'an Connaught Chemical Co., Ltd.; wheat germ oil was purchased from Zhonghe Jianxin Biotechnology Co., Ltd.; beeswax was purchased from Hebei Runze Wax Industry Co., Ltd.; DHA was purchased from Shanghai Jizhi Biochemical Technology Co., Ltd.; blueberry extract was purchased from Tianyun Biotechnology Co., Ltd.

[0027] Example 1

[0028] For myopic people, the following formula and parameters were used to prepare the example:

[0029] A lutein zeaxanthin soft capsule, the capsule core contains lutein, zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, which are homogenized and encapsulated after being mixed with beeswax and wheat germ oil. The mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione and lactoferrin is 1:0.2:24:6:2:2:2:0.8; the capsule shell contains glycerol, deionized water, titanium dioxide, caramel color, carmine, sunset yellow, gelatin, and the mass ratio is 1:2:0.015:0.006:0.003:0.003:0.3.

[0030] The production process of the lutein zeaxanthin soft capsule includes the following steps:

[0031] (1) Heat and melt beeswax and wheat germ oil until they are clear and transparent to obtain an oil-wax mixture;

[0032] (2) Stir and heat wheat germ oil to 55°C, add the oil-wax mixture, stir for 2 min, cool to 32°C, add lutein, pretreated zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and continue to stir for 20 min to obtain an active mixture;

[0033] (3) Homogenize the active mixture with a high-pressure homogenizer at a pressure of 65 MPa and a temperature of 30°C to obtain nano-active ingredients, and then encapsulate the nano-active ingredients to obtain capsule core materials;

[0034] (4) Mix titanium dioxide and deionized water evenly and pass through a 200-mesh sieve to obtain a titanium dioxide suspension;

[0035] (5) Mix sunset yellow, carmine, caramel color and deionized water evenly to obtain a pigment;

[0036] (6) Mix deionized water and glycerol evenly, add the titanium dioxide suspension and the pigment and stir evenly, heat to 70°C, add gelatin, continue to heat to 75°C, stir until the gelatin is completely dissolved, remove air bubbles under vacuum and then let it stand to obtain capsule shell materials;

[0037] (7) The capsule core material and the capsule shell material are made into capsules with a specification of 400 mg per capsule through a soft capsule pill press, and the lutein zeaxanthin soft capsules are obtained through shaping and drying.

[0038] The mass ratio of the wheat germ oil described in step (1) to that in step (2) is 1:1.

[0039] The pretreatment of zeaxanthin described in step (2) is to heat and stir evenly in a water bath at 55 °C.

[0040] The steps of the coating treatment described in step (3) are as follows: maltodextrin, lactose, gelatin, and sodium alginate are added to deionized water, stirred evenly, then nano-active ingredients are added and mixed evenly, and then spray-dried through a spray dryer; the mass ratio of maltodextrin, lactose, gelatin, sodium alginate, deionized water, and nano-active ingredients is 5:2.5:2:0.07:12:9.

[0041] The mass ratio of the deionized water described in step (4), step (5), and step (6) is 1:1:8.

[0042] The viscosity of the capsule shell material described in step (6) is 28000 mPa·s, and the material discharging process of the capsule shell material is filtered through a 100-mesh filter bag; the standing temperature is 60 °C and the time is 12 h.

[0043] The shaping described in step (7) is to send the capsules into a rotating cage for shaping for 3 h, the temperature is 22 °C, and the relative humidity is 30%; the drying is to place the shaped soft capsules on a drying tray, keep the temperature at 25 °C, and dry for 20 h.

[0044] Example 2

[0045] For the elderly and children, the following formula and parameters are used to prepare the example. The main difference from Example 1 is that the proportion of the active substances including wheat germ oil and beeswax is reduced:

[0046] A lutein zeaxanthin soft capsule, the capsule core contains lutein, zeaxanthin, DHA, blueberry extract, glutathione, and lactoferrin. After mixing beeswax and wheat germ oil, homogenization and coating treatment are carried out. The mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione, and lactoferrin is 1:0.1:20:4:1.5:1.5:1.5:0.6; the capsule shell contains glycerol, deionized water, titanium dioxide, caramel color, carmine, sunset yellow, and gelatin, and the mass ratio is 1:1.5:0.01:0.004:0.002:0.002:0.2.

[0047] The production process of the lutein zeaxanthin soft capsule described above includes the following steps:

[0048] (1) Heat beeswax and wheat germ oil until they are melted and clarified to obtain an oil-wax substance;

[0049] (2) Stir and heat wheat germ oil to 50 °C, add the oil-wax substance, stir for 1 min, cool to 30 °C, add lutein, pretreated zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and continue to stir for 15 min to prepare an active mixture;

[0050] (3) Homogenize the active mixture through a high-pressure homogenizer at a pressure of 50 MPa and a temperature of 20 °C to obtain nano-active ingredients, and then perform encapsulation treatment on the nano-active ingredients to obtain the capsule core material;

[0051] (4) Mix titanium dioxide and deionized water evenly, and pass through a 200-mesh sieve to obtain a titanium dioxide suspension;

[0052] (5) Mix sunset yellow, carmine, caramel color and deionized water evenly to obtain a pigment;

[0053] (6) Mix deionized water and glycerol evenly, add the titanium dioxide suspension and the pigment and stir evenly, heat to 65 °C, add gelatin, continue to heat to 70 °C, stir until the gelatin is completely dissolved, remove air bubbles under vacuum and then let it stand to obtain the capsule shell material;

[0054] (7) Pass the capsule core material and the capsule shell material through a soft capsule pill press to make capsules with a specification of 400 mg / capsule, and obtain lutein zeaxanthin soft capsules through shaping and drying.

[0055] The mass ratio of the wheat germ oil described in steps (1) and (2) is 1:1.

[0056] As a preferred technical solution of the present invention, the pretreatment of the zeaxanthin described in step (2) is to heat and stir evenly in a 50 °C water bath.

[0057] The encapsulation treatment step described in step (3) is: add maltodextrin, lactose, gelatin, sodium alginate to deionized water, stir evenly, add nano-active ingredients and mix evenly, and then perform spray drying through a spray dryer; the mass ratio of maltodextrin, lactose, gelatin, sodium alginate, deionized water and nano-active ingredients is 4:2:1:0.05:10:8.

[0058] The mass ratio of the deionized water described in steps (4), (5) and (6) is 1:1:8.

[0059] The viscosity of the capsule shell material described in step (6) is 20000 - 35000 mPa·s, and the discharging process of the capsule shell material is filtered through a 100-mesh filter bag; the standing temperature is 55 °C and the time is 2 h.

[0060] The shaping in step (7) is to send the capsules into a rotating cage for shaping for 2 h at a temperature of 18°C and a relative humidity of 20%; the drying is to place the shaped soft capsules on a drying tray and keep the temperature at 20°C for drying for 16 h.

[0061] Example 3

[0062] For people with excessive eye use, the following formula and parameters are used to prepare the example. The main difference from Example 1 is that the proportion of active substances is relatively large, and the proportions of wheat germ oil and beeswax, including the proportion of the encapsulating substance, are reduced, which is suitable for quickly relieving visual fatigue:

[0063] A lutein zeaxanthin soft capsule, the capsule core contains lutein, zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, which are homogenized and encapsulated after being mixed with beeswax and wheat germ oil. The mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione and lactoferrin is 1:0.3:20:4:2.5:2.5:2.5:1; the capsule shell contains glycerol, deionized water, titanium dioxide, caramel color, carmine, sunset yellow, gelatin, and the mass ratio is 1:2.5:0.02:0.008:0.004:0.004:0.4.

[0064] The production process of the lutein zeaxanthin soft capsule includes the following steps:

[0065] (1) Heat and melt beeswax and wheat germ oil until they are clear and transparent to obtain an oil-wax mixture;

[0066] (2) Stir and heat wheat germ oil to 60°C, add the oil-wax mixture, stir for 1 - 3 min, cool to 35°C, add lutein, pretreated zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and continue to stir for 25 min to obtain an active mixture;

[0067] (3) Homogenize the active mixture through a high-pressure homogenizer at a pressure of 80 MPa and a temperature of 40°C to obtain nano-active ingredients, and then perform an encapsulation treatment on the nano-active ingredients to obtain capsule core materials;

[0068] (4) Mix titanium dioxide and deionized water evenly and pass through a 200-mesh sieve to obtain a titanium dioxide suspension;

[0069] (5) Mix sunset yellow, carmine, caramel color and deionized water evenly to obtain a pigment;

[0070] (6) Mix deionized water and glycerol evenly, add the titanium dioxide suspension and the pigment and stir evenly, heat to 75°C, add gelatin, continue to heat to 80°C, stir until the gelatin is completely dissolved, remove bubbles under vacuum and then let it stand to obtain capsule shell materials;

[0071] (7) The capsule core material and the capsule shell material are made into capsules with a specification of 400 mg per capsule through a soft capsule pill press. After shaping and drying, lutein and zeaxanthin soft capsules are obtained.

[0072] The mass ratio of the wheat germ oil described in step (1) to that in step (2) is 1:1.

[0073] The pretreatment of zeaxanthin described in step (2) is to heat and stir evenly in a water bath at 60 °C.

[0074] The encapsulation treatment steps described in step (3) are as follows: Maltodextrin, lactose, gelatin, and sodium alginate are added to deionized water. After stirring evenly, nano-active ingredients are added and mixed evenly, and then spray-dried through a spray dryer; the mass ratio of maltodextrin, lactose, gelatin, sodium alginate, deionized water, and nano-active ingredients is 4:2:1:0.05:10:10.

[0075] The mass ratio of the deionized water described in step (4), step (5), and step (6) is 1:1:8.

[0076] The viscosity of the capsule shell material described in step (6) is 35000 mPa·s, and the discharging process of the capsule shell material is filtered through a 100-mesh filter bag; the standing temperature is 70 °C and the time is 24 h.

[0077] The shaping described in step (7) is to send the capsules into a rotating cage for shaping for 4 h, with a temperature of 26 °C and a relative humidity of 40%; the drying is to place the shaped soft capsules on a drying tray, keep the temperature at 30 °C, and dry for 24 h.

[0078] Comparative Example 1

[0079] On the basis of Example 1, wheat germ oil is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, beeswax, DHA, blueberry extract, glutathione, and lactoferrin is changed to 1:0.2:30:2:2:2:0.8, and the rest is the same as in Example 1.

[0080] Comparative Example 2

[0081] On the basis of Example 1, beeswax is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, wheat germ oil, DHA, blueberry extract, glutathione, and lactoferrin is changed to 1:0.2:30:2:2:2:0.8, and the rest is the same as in Example 1.

[0082] Comparative Example 3

[0083] On the basis of Example 1, the capsule core mixture is not subjected to high-pressure homogenization treatment, and the rest is the same as in Example 1.

[0084] Example 4

[0085] On the basis of Example 1, the nano-active ingredient is not encapsulated, and the rest is the same as in Example 1.

[0086] Comparative Example 5

[0087] On the basis of Example 1, DHA is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, blueberry extract, glutathione and lactoferrin is changed to 1:0.2:24:6:4:2:0.8, and the rest is the same as in Example 1.

[0088] Comparative Example 6

[0089] On the basis of Example 1, blueberry extract is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, glutathione and lactoferrin is changed to 1:0.2:24:6:2:4:0.8, and the rest is the same as in Example 1.

[0090] Comparative Example 7

[0091] On the basis of Example 1, glutathione is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract and lactoferrin is changed to 1:0.2:24:6:2:2:2.8, and the rest is the same as in Example 1.

[0092] Comparative Example 8

[0093] On the basis of Example 1, lactoferrin is not added to the capsule core, and the mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione is changed to 1:0.2:24:6:2.8:2:2, and the rest is the same as in Example 1.

[0094] Performance test:

[0095] Stability test: Take the capsules prepared in Examples 1-3 and Comparative Examples 1-4, place them in evaporating dishes respectively, and place them in an oven with a constant temperature of 150 °C. Measure the lutein ester content in the lutein ester microcapsules after 1 h and 2 h, and calculate the retention rate. The retention rate of the lutein ester microcapsules is the ratio of the content of lutein ester after the sample is stored for a period of time to the initial content of lutein ester in the sample.

[0096] Effect test: The efficacy of the present invention was tested according to the test method for alleviating visual fatigue function in the "Technical Specifications for the Inspection and Evaluation of Health Foods" (2003 edition). Adults who use their eyes for a long time and are prone to visual fatigue were selected as the test population. The experimental group took Examples 1-3 and Comparative Examples 1-8, 1 capsule each time, 3 times a day, and the control group took a placebo. The appearance and dosage of the placebo were the same as those of the experimental group; the test period was 30 days, and the original eating habits were not changed during the test, and the subjects had normal diets.

[0097] Efficacy determination criteria:

[0098] Improvement of ophthalmic symptoms: If any one of the symptoms of eye pain, eye swelling, photophobia, blurred vision, and dry eyes improves by 1 point or more, it is considered an improvement. If any one of the 5 symptoms improves and other symptoms do not deteriorate, it is determined that the symptoms have improved.

[0099] Effective: The symptoms improve and the difference in the duration of clear vision before and after is greater than or equal to 0.1.

[0100] Invalid: The effective standard is not met.

[0101] Duration of clear vision = Clear vision time / Total fixation time

[0102] Improvement rate % = Number of effective people / Total number. Ineffective means that the symptoms remain unchanged or worsen, and effective means that the symptoms disappear or improve.

[0103]

[0104] By comparing the lutein ester retention rates of Example 1 and Comparative Examples 1-2, it can be seen that the present invention mixes wheat germ oil and beeswax with active substances, which can synergistically increase the dispersibility and stability of active ingredients. By comparing the lutein ester retention rates of Example 1 and Comparative Example 3, it can be seen that using a high-pressure homogenizer for homogenization treatment can further ensure uniform dispersion of components; by comparing the lutein ester retention rates of Example 1 and Comparative Example 4, it can be seen that encapsulating active ingredients can significantly increase the stability of active ingredients;

[0105] By comparing the improvement results of ophthalmic symptoms of Examples 1-3 and Comparative Examples 1-4, it can be seen that the present invention helps to stabilize and slow-release functional substances by mixing and encapsulating active substances with wheat germ oil and beeswax. By comparing the improvement results of ophthalmic symptoms of Examples 1-4 and Comparative Examples 5-8 and the control group, it can be seen that the active ingredients of lutein, zeaxanthin, DHA, blueberry extract, glutathione, and lactoferrin in the present invention synergistically improve the efficacy of the capsules in alleviating visual fatigue.

[0106] The above are only the preferred embodiments of the present invention, and do not impose any form of limitation on the present invention. Although the present invention has been disclosed above with the preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some changes or modifications to equivalent embodiments by using the disclosed technical content within the scope of the technical solution of the present invention. However, as long as it does not depart from the content of the technical solution of the present invention, any indirect modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention still fall within the scope of the technical solution of the present invention.

Claims

1. A lutein and zeaxanthin soft capsule, characterized in that: The capsule core contains lutein, zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, which are mixed with beeswax and wheat germ oil and then homogenized and wrapped. The mass ratio of lutein, zeaxanthin, wheat germ oil, beeswax, DHA, blueberry extract, glutathione and lactoferrin is 1:0.1-0.3:20-28:4-8:1.5-2.5:1.5-2.5:1.5-2.5:0.6-1; the capsule shell contains glycerol, deionized water, titanium dioxide, caramel color, carmine, sunset yellow and gelatin, and the mass ratio is 1:1.5-2.5:0.01-0.02:0.004-0.008:0.002-0.004:0.002-0.004:0.2-0.

4.

2. A production process for the lutein zeaxanthin soft capsule according to claim 1, characterized in that: The following steps are involved: (1) heating and melting beeswax and wheat germ oil until they are clear and transparent to obtain an oil-wax product; (2) stirring and heating the wheat germ oil to 50-60° C., adding the oil wax, stirring for 1-3 minutes, cooling to 30-35° C., adding lutein, pretreated zeaxanthin, DHA, blueberry extract, glutathione and lactoferrin, and continuing to stir for 15-25 minutes to prepare an active mixture; (3) homogenizing the active mixture through a high-pressure homogenizer at a pressure of 50-80 MPa and a temperature of 20-40° C. to obtain a nano-active ingredient, and then encapsulating the nano-active ingredient to obtain a capsule core material; (4) mixing titanium dioxide and deionized water uniformly and filtering through a 200-mesh sieve to obtain a titanium dioxide suspension; (5) Evenly mixing sunset yellow, carmine, caramel and deionized water to prepare a pigment; (6) Mix deionized water and glycerin evenly, add titanium dioxide suspension and pigment and stir evenly, heat to 65-75° C., add gelatin, continue to heat to 70-80° C., stir until the gelatin is completely dissolved, remove bubbles in vacuo, and then stand to obtain a capsule shell material; (7) The capsule core material and the capsule shell material are processed into capsules with a specification of 400 mg / capsule by a soft capsule pelletizing machine, and the lutein and zeaxanthin soft capsules are obtained by shaping and drying.

3. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: The mass ratio of the wheat germ oil in step (1) and step (2) is 1:

1.

4. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: The zeaxanthin pretreatment in step (2) is performed by heating in a water bath at 50-60° C. and stirring evenly.

5. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: The encapsulation step in step (3) is as follows: adding maltodextrin, lactose, gelatin and sodium alginate into deionized water, stirring evenly, adding nano-active ingredients and mixing evenly, and then spray drying by a spray dryer; the mass ratio of maltodextrin, lactose, gelatin, sodium alginate, deionized water and nano-active ingredients is 4-6:2-3:1-3:0.05-0.1:10-15:8-10.

6. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: The mass ratio of the deionized water in step (4), step (5) and step (6) is 1:1:

8.

7. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: In step (6), the viscosity of the capsule shell material is 20000-35000 mPa·s, and the capsule shell material is filtered through a 100-mesh filter bag during discharge; the standing temperature is 55-70° C., and the standing time is 2-24 h.

8. The production process of a lutein zeaxanthin soft capsule according to claim 2, characterized in that: The shaping in step (7) is to put the capsules into a rotating cage for shaping for 2-4 hours at a temperature of 18-26° C. and a relative humidity of ≤40%; the drying is to place the shaped capsules in a drying tray at a temperature of 20-30° C. for drying for 16-24 hours.

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