Preparation method of traditional Chinese medicine composition for relieving osteoporosis and nourishing

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a preparation method of a bone-relaxing nourishing traditional Chinese medicine composition, the traditional Chinese medicine composition is prepared from, by weight, 10 g of eucommia ulmoides, 15 g of prepared rehmannia root, 30 g of astragalus membranaceus, 10 g of herba epimedii, 10 g of dogwood, 10 g of angelica sinensis, 10 g of rhizoma alismatis, 10 g of poria cocos, 10 g of obscured homalomena rhizome and 10 g of morinda officinalis, and the preparation method comprises the steps that the eucommia ulmoides, the morinda officinalis and the obscured homalomena rhizome are added into a decoction container; decocting with slow fire for 30 minutes; adding the prepared rehmannia root, the astragalus membranaceus, the dogwood, the rhizoma alismatis and the poria cocos into the decoction container, and continuously decocting for 40 minutes; adding the herba epimedii and the angelica sinensis into the decoction container, decocting for 10 minutes, filtering, and remaining medicine residues in the decoction container; adding water, decocting with slow fire for 40 minutes, and filtering; and merging the decoctions decocted twice, filtering, and concentrating to obtain the traditional Chinese medicine composition. The problems that herbal medicine compatibility focuses on single efficacy, the treatment effect cannot be maximized, and side effects cannot be minimized are solved.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine compositions, and particularly to a preparation method of a Gusong Anyang traditional Chinese medicine composition. Background Art

[0002] As a metabolic bone disease with bone mass loss and bone microstructure damage as the pathological core, osteoporosis has become a major public health challenge faced by the global aging society. Epidemiological data shows that the prevalence rate of people over 50 years old in China reaches 19.2%, and the incidence rate of postmenopausal women is as high as 32.1%. The resulting fragility fractures occur in more than 2.6 million cases every year, seriously threatening the quality of life of patients. Although modern medicine intervenes in bone metabolism through drugs such as bisphosphonates and RANKL inhibitors, long-term application is prone to side effects such as jaw necrosis and cardiovascular risks, and the patient compliance is less than 40%.

[0003] Based on the theoretical system of "the kidney governs bones and produces marrow", traditional Chinese medicine attributes osteoporosis to the category of "bone flaccidity", proposes the core pathogenesis of "the liver and kidney share the same origin and essence and blood transform into each other", and emphasizes the regulation of the bone-marrow-tendon system by tonifying the kidney and filling essence, promoting blood circulation and dredging collaterals. Although existing traditional Chinese medicine compound prescriptions such as Qing'e Pills and Jianbu Huqian Pills embody the concept of tonifying the kidney and strengthening bones, they generally focus more on the single efficacy of tonifying kidney yang or nourishing kidney yin in the formula, and fail to systematically integrate the multi-dimensional intervention strategies of "tonifying the kidney and filling essence - replenishing qi and promoting blood circulation - removing dampness and dredging collaterals", resulting in a low remission rate of bone bi.

[0004] Chinese Patent Publication No.: CN102824504B discloses a traditional Chinese medicine composition for tonifying the kidney and strengthening bones. The traditional Chinese medicine composition is made from the following Chinese medicinal materials in parts by mass: 15 parts of Rehmannia glutinosa, 8 - 10 parts of Cornus officinalis, 15 - 18 parts of Dioscorea opposita, 15 - 18 parts of Lycium barbarum, 8 - 10 parts of Achyranthes bidentata, 8 - 10 parts of Epimedium brevicornu, 8 - 10 parts of Psoralea corylifolia, and 10 - 12 parts of Dipsacus asperoides. It can be prepared according to the conventional traditional Chinese medicine preparation method. For example: after mixing the various Chinese medicinal materials for making the traditional Chinese medicine composition, adding water for decoction, filtering after the decoction is completed, and collecting the filtrate to obtain the traditional Chinese medicine composition mixture. The amount of crude drug in each milliliter of the traditional Chinese medicine composition mixture can be 2.86 - 3.86 g. Pharmacological experiments prove that: the traditional Chinese medicine composition for tonifying the kidney and strengthening bones of the present invention can effectively improve the endocrine imbalance in the body and supplement the nutritional structure in the body, thus having the effect of improving bone density and can be used for preventing and treating osteoporosis.

[0005] There are also the following problems in the prior art: when treating bone bi caused by liver and kidney deficiency, the multi-dimensional intervention strategies of "tonifying the kidney and filling essence - replenishing qi and promoting blood circulation - removing dampness and dredging collaterals" are not systematically integrated, resulting in a low remission rate of bone bi. Summary of the Invention

[0006] To this end, the present invention provides a preparation method of a traditional Chinese medicine composition for treating osteoporosis and promoting health, so as to overcome the problem in the prior art that the compatibility of traditional Chinese herbs focuses on a single efficacy, resulting in a low remission rate of bone bi.

[0007] To achieve the above object, the present invention provides a preparation method of a traditional Chinese medicine composition for treating osteoporosis and promoting health, comprising:

[0008] Add water eight times the total amount of the medicinal materials into a decocting container and heat to boiling.

[0009] Add Eucommia ulmoides Oliv., Morinda officinalis How and Homalomena occulta (Lour.) Schott into the said decocting container and decoct with slow fire for 30 minutes.

[0010] Add Rehmannia glutinosa Libosch. preparata, Astragalus membranaceus (Fisch.) Bunge, Cornus officinalis Sieb. et Zucc., Alisma orientale (Sam.) Juz. and Poria cocos (Schw.) Wolf into the said decocting container and continue to decoct for 40 minutes.

[0011] Add Epimedium brevicornu Maxim. and Angelica sinensis (Oliv.) Diels into the said decocting container, decoct for 10 minutes and then filter, leaving the medicinal residues in the decocting container.

[0012] Add water six times the total amount of the medicinal materials into the decocting container, heat to boiling, turn to slow fire and decoct for 40 minutes and then filter.

[0013] Combine the decoctions of the two decoctions, filter through double-layer gauze and concentrate to 300 ml to obtain the traditional Chinese medicine composition.

[0014] Further, the monarch drugs of the traditional Chinese medicine composition are Eucommia ulmoides Oliv. and Rehmannia glutinosa Libosch. preparata, the ministerial drugs are Epimedium brevicornu Maxim., Cornus officinalis Sieb. et Zucc., Angelica sinensis (Oliv.) Diels, Alisma orientale (Sam.) Juz., Homalomena occulta (Lour.) Schott, Poria cocos (Schw.) Wolf and Morinda officinalis How, and the adjuvant drug is Astragalus membranaceus (Fisch.) Bunge.

[0015] Further, the components of the traditional Chinese medicine composition are in the following parts by weight: Eucommia ulmoides Oliv. 8 - 12 g, Rehmannia glutinosa Libosch. preparata 13 - 17 g, Astragalus membranaceus (Fisch.) Bunge 25 - 35 g, Epimedium brevicornu Maxim. (Epimedium brevicornu Maxim.) 8 - 12 g, Cornus officinalis Sieb. et Zucc. 8 - 12 g, Angelica sinensis (Oliv.) Diels 8 - 12 g, Alisma orientale (Sam.) Juz. 8 - 12 g, Poria cocos (Schw.) Wolf 8 - 12 g, Homalomena occulta (Lour.) Schott 8 - 12 g, Morinda officinalis How 8 - 12 g.

[0016] Further, the components of the traditional Chinese medicine composition are in the following parts by weight: Eucommia ulmoides Oliv. 10 g, Rehmannia glutinosa Libosch. preparata 15 g, Astragalus membranaceus (Fisch.) Bunge 30 g, Epimedium brevicornu Maxim. (Epimedium brevicornu Maxim.) 10 g, Cornus officinalis Sieb. et Zucc. 10 g, Angelica sinensis (Oliv.) Diels 10 g, Alisma orientale (Sam.) Juz. 10 g, Poria cocos (Schw.) Wolf 10 g, Homalomena occulta (Lour.) Schott 10 g, Morinda officinalis How 10 g.

[0017] Further, the mass ratio of Eucommia ulmoides Oliv. to Rehmannia glutinosa Libosch. preparata is 1:1.3 - 1.7.

[0018] Further, the mass ratio of Epimedium brevicornu Maxim. to Rehmannia glutinosa Libosch. preparata is 1:1.3 - 1.7.

[0019] Further, the density of the traditional Chinese medicine composition is 1.1 - 1.5 g / cm 3 。

[0020] Furthermore, the concentration process of the decoction includes heating under reduced pressure to evaporate water to obtain the traditional Chinese medicine composition, wherein the pressure is not greater than 188 mmHg and the evaporation temperature is 35 - 65°C.

[0021] Furthermore, the shelf life of the traditional Chinese medicine composition is 7 days, and the refrigeration temperature is 2 - 5°C.

[0022] Furthermore, the administration method of the traditional Chinese medicine composition is one dose per day, taken three times after dilution with water.

[0023] Compared with the prior art, the beneficial effects of the present invention are that it can tonify the kidney and strengthen the bones, replenish qi and nourish yin. It is used for joint diseases caused by bone bi syndrome of liver and kidney deficiency, with symptoms such as continuous bone pain (mainly in the lower back and hips), aggravated by cold or fatigue, joint stiffness (morning stiffness < 30 minutes), bone friction sensation during movement, heel pain, and heavy and weak lower limbs when walking.

[0024] The present invention is an innovative traditional Chinese medicine compound constructed based on the theory of "the kidney governing the bones and generating marrow" in traditional Chinese medicine, and is specially designed for treating joint pain caused by bone bi syndrome of liver and kidney deficiency. Through the reasonable compatibility of monarch, minister, assistant, and envoy herbs, it achieves the comprehensive therapeutic effect of tonifying the kidney and strengthening the bones, replenishing qi and nourishing yin, thus effectively alleviating the main symptoms of patients with bone bi syndrome.

[0025] To enhance the therapeutic effect, the present invention adopts a dual synergistic mechanism of "monarch, minister, assistant, and envoy + sequential decoction". The monarch herbs Eucommia ulmoides and Rehmannia glutinosa form the core of tonifying the kidney and filling essence, the minister herb combination of Epimedium brevicornu - Morinda officinalis constructs a network of warming yang and strengthening tendons, and the assistant herb Astragalus membranaceus establishes a hub for qi and blood generation. Through the staged decoction process (first decocting the bony herbs and then adding the tonifying components), the gradient release of active ingredients is achieved, enabling the three effects of tonifying the liver and kidney, strengthening the bones and tendons, and replenishing qi and blood to work synergistically, forming a three - dimensional treatment system, thereby alleviating joint pain.

[0026] The innovative "yin - yang dual tonifying - essence - blood co - regulating" ratio model is applied in the formula. The golden ratio of Eucommia ulmoides (yang) and Rehmannia glutinosa (yin) realizes the mutual rooting of yin and yang; the precise compatibility of Epimedium brevicornu and Rehmannia glutinosa ensures the generation of essence and blood. Together with the qi - blood dual - tonifying effect of the classic herb pair Angelica sinensis - Astragalus membranaceus, a negative feedback regulation mechanism for bone metabolism is established. Through two - stage gradient decoction combined with the reduced - pressure concentration process, the extraction rate of small - molecule active substances (such as eucommiol and alisol A) is increased, while protecting heat - sensitive components (such as cornelian cherry glycoside and ferulic acid).

[0027] The present invention realizes the synergistic effect between drugs through the synergistic action of multiple components, forming a complex treatment network, which can treat osteoporosis comprehensively and multi - dimensionally. The combined application of multiple herbs organically combines herbs with different effects, not only giving full play to the unique curative effects of various herbs but also avoiding the possible side effects of single herbs, achieving the maximization of therapeutic effects and the minimization of side effects.

[0028] This traditional Chinese medicine prescription shows remarkable innovation in aspects such as the synergistic effect of multiple components, personalized treatment, the combined application of various herbs, and the innovation of traditional Chinese medicine preparations, providing a new method and idea for treating joint pain caused by bone bi. Brief Description of the Drawings

[0029] Figure 1 It is a flowchart of the preparation method of the Gusu Anyang traditional Chinese medicine composition according to the embodiment of the present invention. Detailed Embodiments

[0030] In order to make the objectives and advantages of the present invention clearer, the present invention will be further described below in conjunction with embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0031] For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0032] The embodiment of the present invention provides a preparation method of a Gusu Anyang traditional Chinese medicine composition, including:

[0033] Step S1, adding water 8 times the total amount of medicinal materials into a decocting container and heating to boiling;

[0034] Step S2, adding Eucommia ulmoides Oliv., Morinda officinalis How, and Homalomena occulta (Lour.) Schott into the decocting container and decocting gently for 30 minutes;

[0035] Step S3, adding Rehmannia glutinosa Libosch. preparata, Astragalus membranaceus (Fisch.) Bunge, Cornus officinalis Sieb. et Zucc., Alisma orientale (Sam.) Juzep., and Poria cocos (Schw.) Wolf into the decocting container and continuing to decoct for 40 minutes;

[0036] Step S4, adding Epimedium brevicornu Maxim. and Angelica sinensis (Oliv.) Diels into the decocting container, decocting for 10 minutes and then filtering, leaving the medicinal residues in the decocting container;

[0037] Step S5, adding water 6 times the total amount of medicinal materials into the decocting container, heating to boiling, turning to gentle fire and decocting for 40 minutes and then filtering;

[0038] Step S6, combining the decoction liquids of the two decoctions, filtering through double-layer gauze and concentrating to 300 ml to obtain the traditional Chinese medicine composition;

[0039] Step S7, packaging the traditional Chinese medicine composition and storing it refrigerated.

[0040] It can be understood that gentle fire refers to a temperature of 85 - 90 °C.

[0041] Specifically, the monarch drugs of the traditional Chinese medicine composition are Eucommia ulmoides Oliv. and Rehmannia glutinosa Libosch. preparata, the ministerial drugs are Epimedium brevicornu Maxim., Cornus officinalis Sieb. et Zucc., Angelica sinensis (Oliv.) Diels, Alisma orientale (Sam.) Juzep., Homalomena occulta (Lour.) Schott, Poria cocos (Schw.) Wolf, and Morinda officinalis How, and the adjuvant drug is Astragalus membranaceus (Fisch.) Bunge.

[0042] Specifically, the traditional Chinese medicine composition comprises the following components in parts by weight: Eucommia ulmoides 8 - 12 g, Rehmannia glutinosa 13 - 17 g, Astragalus membranaceus 25 - 35 g, Epimedium brevicornu 8 - 12 g, Cornus officinalis 8 - 12 g, Angelica sinensis 8 - 12 g, Alisma orientale 8 - 12 g, Poria cocos 8 - 12 g, Homalomena occulta 8 - 12 g, Morinda officinalis 8 - 12 g.

[0043] Specifically, the traditional Chinese medicine composition comprises the following components in parts by weight: Eucommia ulmoides 10 g, Rehmannia glutinosa 15 g, Astragalus membranaceus 30 g, Epimedium brevicornu 10 g, Cornus officinalis 10 g, Angelica sinensis 10 g, Alisma orientale 10 g, Poria cocos 10 g, Homalomena occulta 10 g, Morinda officinalis 10 g.

[0044] Specifically, the mass ratio of Eucommia ulmoides to Rehmannia glutinosa is 1:1.3 - 1.7.

[0045] Specifically, the mass ratio of Epimedium brevicornu to Rehmannia glutinosa is 1:1.3 - 1.7.

[0046] Specifically, the density of the traditional Chinese medicine composition is 1.1 - 1.5 g / cm 3 。

[0047] Specifically, the concentration process of the decoction includes heating under reduced pressure to evaporate water to obtain the traditional Chinese medicine composition, wherein the pressure is not more than 188 mmHg and the evaporation temperature is 35 - 65 °C.

[0048] Specifically, the shelf life of the traditional Chinese medicine composition is 7 days and the refrigeration temperature is 2 - 5 °C.

[0049] Specifically, the taking method of the traditional Chinese medicine composition is one dose per day, taken three times after dilution with water.

[0050] Specifically, the taking method of the traditional Chinese medicine composition is to divide 300 ml of the liquid medicine of one dose into 3 equal parts, and each part is mixed with water in a ratio of 1:1 and heated to 40 - 50 °C before taking.

[0051] In the embodiment of the present invention, Eucommia ulmoides and Rehmannia glutinosa are used as the monarch drugs, mainly for tonifying the kidney and strengthening the bones, nourishing yin and generating marrow; Eucommia ulmoides is sweet, slightly pungent, and warm, with the effects of tonifying the liver and kidney, strengthening the bones and muscles; Rehmannia glutinosa nourishes yin and replenishes blood, benefits essence and fills the marrow. The two drugs enter the liver and kidney meridians together, and jointly play the role of tonifying the kidney and strengthening the bones, nourishing yin and generating marrow. "Plain Questions·Theory of Flaccidity" states: "When the kidney qi is hot, the waist and spine cannot support, the bones wither and the marrow decreases, resulting in bone flaccidity." Eucommia ulmoides tonifies the kidney and strengthens the tendons, while Rehmannia glutinosa nourishes yin and fills the marrow. The combination of the two drugs tonifies the kidney and fills the marrow, reflecting the idea of treating diseases from the root in traditional Chinese medicine; Epimedium, Cornus officinalis, Angelica sinensis, Alisma orientale, Homalomena occulta, Poria cocos, Morinda officinalis are used as ministerial drugs; Epimedium and Cornus officinalis jointly play the role of tonifying the kidney and strengthening yang, and cooperate with Rehmannia glutinosa to tonify both yin and yang, enabling the body to have a source for the transformation of yin and yang, and the bones and muscles to be nourished; Homalomena occulta and Morinda officinalis both have the effects of dispelling wind-dampness and strengthening the bones and muscles, complementing Eucommia ulmoides, and further enhancing the effect of strengthening the bones and muscles; Angelica sinensis enters the heart, liver, and spleen meridians, with the effect of promoting blood circulation and nourishing blood. While nourishing the body's yin blood, it can also promote blood circulation and make the drugs reach all parts of the body; The combination of Alisma orientale and Poria cocos can promote diuresis and remove dampness. In the Lingnan region, the humidity is relatively heavy. The combination of the two drugs has the effect of removing dampness and turbidity. In addition, Alisma orientale is cold in nature and can prevent the excessive warmth and dryness of various drugs from damaging the healthy qi. Poria cocos can enter the heart and spleen meridians and has the function of calming the mind and soothing the nerves. Used here, it can also help the patient to regulate and nourish the body and mind; Astragalus membranaceus is used as an assistant drug, with the effect of replenishing qi. Astragalus membranaceus is used in large doses in the formula and cooperates with Angelica sinensis, Poria cocos, etc. to prevent the excessive greasiness of various drugs from damaging the spleen and stomach. In addition, qi can carry the drugs, enabling the drugs to reach the meridians of the human body, making the whole body unobstructed, and further enhancing the effect of tonifying the kidney and strengthening the bones.

[0052] Example 1

[0053] Prepared from raw materials with the following quality:

[0054] 10 g of Eucommia ulmoides, 15 g of Rehmannia glutinosa, 30 g of Astragalus membranaceus, 10 g of Epimedium (Epimedium brevicornum), 10 g of Cornus officinalis, 10 g of Angelica sinensis, 10 g of Alisma orientale, 10 g of Poria cocos, 10 g of Homalomena occulta, 10 g of Morinda officinalis. After two decoctions and concentration, 300 ml of traditional Chinese medicine composition is obtained.

[0055] Clinical efficacy observation of Example 1

[0056] Case 1:

[0057] Patient: Li XX, female, 60 years old;

[0058] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0059] Western medicine diagnosis: Joint disease (right knee)

[0060] Chief complaint: Pain in the right knee joint for more than 1 year;

[0061] Medical condition: One year ago, the patient accidentally sprained and had pain in the right knee joint, accompanied by limited mobility. There was no obvious history of trauma. The pain worsened when going up and down stairs, when the weather turned cold, or after fatigue, and was more severe when starting to walk after sitting for a long time. The WOMAC score of the knee joint was 22 points, and the VAS score was 6 points. The tongue was purplish and dull, with stasis points, and the pulse was stringy and thready.

[0062] Physical examination: The range of motion of the right knee joint was 0° - 130°. The floating patella test was (-), the patella grinding test was (+), the anterior and posterior drawer tests were (-), the medial joint space tenderness was (-), and the lateral joint space tenderness was (+).

[0063] Treatment method and condition: After seeing a doctor, the patient was treated with the traditional Chinese medicine composition prepared in Example 1. After 3 weeks of treatment, the WOMAC score of the knee joint dropped to 20 points, and the VAS score dropped to 5 points. The tongue was purplish and dull, the tongue coating was yellow and thick, and the pulse was stringy and thready. After continuing the treatment for 1 week, the WOMAC score of the knee joint dropped to 19 points, and the VAS score dropped to 4 points. The tongue was purplish and dull, the tongue coating was yellow and thick, and the pulse was stringy and thready. The tongue was purplish and dull, the tongue coating was white, greasy and slightly yellow, and the pulse was stringy and thready. After continuing the treatment for 1 week, the WOMAC score of the knee joint dropped to 16 points, and the VAS score dropped to 2 points. The tongue was pale and dull, with tooth marks on the sides, the tongue coating was white and greasy, and the pulse was stringy. After continuing the treatment for 1 week, the WOMAC score of the knee joint dropped to 12 points, and the VAS score dropped to 1 point. After continuing the treatment for 1 week, the WOMAC score of the knee joint dropped to 10 points, and the VAS score dropped to 1 point. The tongue was dark red, the tongue coating was slightly white and greasy, and the pulse was stringy. The symptoms were significantly relieved, and there was no joint pain, so the patient was cured.

[0064] Case 2:

[0065] Patient: Li XX, female, 66 years old;

[0066] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0067] Western medicine diagnosis: Arthropathy (lumbar spine);

[0068] Chief complaint: Tight pain and discomfort in the waist for more than 5 months;

[0069] Medical condition: The patient reported tight pain in the lumbosacral region 5 months ago, occasionally involving the lower limbs. The bilateral lumbar muscles were firm, with local tenderness. The straight leg raising test on the right side was (+ -). The symptoms slightly worsened when bending over, and the range of motion of the lumbar spine decreased. The mJOA score of the lumbar spine was 15 points, and the VAS score was 7 points. The tongue was dull, the tongue coating was thin and white, and the pulse was stringy and slippery.

[0070] Treatment method and condition: After the visit, the patient was treated with the traditional Chinese medicine preparation prepared in Example 1. After 1 week of treatment, the lumbar mJOA score was 13 points, the VAS score was 6 points, the tongue was dull, the coating was slightly greasy and white, and the pulse was string-like and slippery; after continuing the treatment for 1 week, the lumbar mJOA score was 12 points, the VAS score was 5 points, the tongue was dull red, the coating was thin and white, and the pulse was string-like; after continuing the treatment for 1 week, the lumbar mJOA score was 11 points, the VAS score was 4 points, the tongue was dull red, the coating was yellow and greasy, and the pulse was string-like and slippery. The symptoms were significantly relieved and there was no joint pain, so the patient was cured.

[0071] Case 3:

[0072] Patient: Li Moumou, female, 68 years old;

[0073] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0074] Western medicine diagnosis: Arthropathy (left metacarpophalangeal joint of the big toe);

[0075] Chief complaint: Pain and discomfort in the left metacarpophalangeal joint of the big toe for more than 1 year;

[0076] Disease condition: The patient reported that pain and discomfort in the left metacarpophalangeal joint of the big toe occurred 1 year ago, with slight swelling on the side of the Achilles tendon and obvious local tenderness; VAS score was 7 points, the tongue was pale and dull, the coating was thin and few, and the pulse was string-like and thin.

[0077] Physical examination: Pain and discomfort in the left metacarpophalangeal joint of the big toe, with slight swelling on the side of the Achilles tendon.

[0078] Treatment method and condition: After the visit, the patient was treated with the traditional Chinese medicine preparation prepared in Example 1. After 1 week of treatment, the symptoms were slightly relieved, the VAS score was 6 points, the tongue was pale and dull, the coating was thin, and the pulse was string-like and thin; after continuing the treatment for 1 week, the VAS score was 4 points, the tongue was dull, the coating was white, greasy and slightly yellow, and the pulse was string-like; after continuing the treatment for 1 week, the VAS score was 2 points, the tongue was dull, the coating was few, and the pulse was string-like and slippery. There was no joint pain, so the patient was cured.

[0079] Case 4:

[0080] Patient: Luo Moumou, female, 62 years old;

[0081] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0082] Western medicine diagnosis: Arthropathy (right heel);

[0083] Chief complaint: Pain in the right heel for more than 1 week.

[0084] Disease condition: The patient reported that pain in the right heel occurred 1 week ago, and the symptoms were significantly aggravated after walking for a long time and relieved after rest, with no obvious change after standing for a long time, and occasionally accompanied by discomfort in the right knee joint; VAS score was 6 points, the tongue was dull, the coating was slightly greasy and white, and the pulse was string-like and slippery.

[0085] Physical examination: There was no swelling in the right heel, and there was slight tenderness below the posterior part of the medial malleolus.

[0086] Treatment method and condition: After the visit, the patient was treated with the traditional Chinese medicine preparation prepared in Example 1. After 1 week of treatment, the VAS score was 5 points, the tongue was pale and dull, the tongue coating was white and greasy, and the pulse was string-like and slippery. After continuing the treatment for 2 weeks, the VAS score was 4 points, the tongue was pale red, the tongue coating was thin and white, the pulse was string-like, the symptoms were significantly relieved, and there was no joint pain, that is, the patient was cured.

[0087] Case 5:

[0088] Patient: Deng XX, female, 53 years old;

[0089] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0090] Western medicine diagnosis: Arthropathy (cervical vertebra);

[0091] Chief complaint: Pain in the right side of the neck accompanied by numbness in the right upper limb for more than 1 month;

[0092] Disease condition: Pain in the right side of the neck occurred more than 1 month ago, involving obvious numbness in the right upper limb; local tenderness, limited movement, and the pain aggravated during movement; no dizziness, no headache; The mJOA score of the cervical vertebra was 14 points, the Constant-Murley score of the shoulder was 85 points, and the VAS score was 8 points; the tongue was pale and dull, the tongue coating was white and greasy, and the pulse was string-like.

[0093] Treatment method and condition: After the visit, the patient was treated with the traditional Chinese medicine preparation prepared in Example 1. After 2 weeks of treatment, the mJOA score of the cervical vertebra was 15 points, the Constant-Murley score of the shoulder was 87 points, and the VAS score was 7 points; the tongue was dull, the tongue coating was white, greasy and slightly yellowish, and the pulse was string-like and slippery. After continuing the treatment for 1 week, the mJOA score of the cervical vertebra was 16 points, the Constant-Murley score of the shoulder was 89 points, and the VAS score was 5 points; the tongue was dull, the tongue coating was white and greasy, and the pulse was string-like and slippery. The symptoms were significantly relieved, and there was no joint pain, that is, the patient was cured.

[0094] Case 6:

[0095] Patient: Chen XX, male, 73 years old;

[0096] Traditional Chinese medicine diagnosis: Bone Bi, syndrome of deficiency of liver and kidney;

[0097] Western medicine diagnosis: Arthropathy (lumbar vertebra);

[0098] Chief complaint: Soreness and pain in the lumbosacral region for more than 1 month;

[0099] Disease condition: The patient reported soreness and discomfort in the lumbosacral region 1 month ago, without obvious involvement of the lower limbs, felt stiffness and discomfort in both knees, the bilateral lumbar muscles were tight, there was no obvious local tenderness, the straight leg raising test result was negative, and felt bitter taste in the mouth and dry mouth; The mJOA score of the lumbar vertebra was 16 points, and the VAS score was 5 points; the tongue was dark red, the tongue coating was greasy and slightly yellowish, and the pulse was string-like.

[0100] Treatment method and condition: After the visit, the traditional Chinese medicine preparation prepared in Example 1 was given for treatment. After 1 week of treatment, the lumbar mJOA score was 16 points and the VAS score was 5 points; the tongue was dull, the coating was greasy and slightly yellow, the pulse was string-like, and the low back pain was significantly relieved compared with before, without joint pain, that is, cured.

[0101] So far, the technical solution of the present invention has been described in conjunction with the preferred embodiments shown in the drawings. However, it is easy for those skilled in the art to understand that the protection scope of the present invention is obviously not limited to these specific embodiments. Without departing from the principle of the present invention, those skilled in the art can make equivalent changes or substitutions to the relevant technical features, and the technical solutions after these changes or substitutions will fall within the protection scope of the present invention.

Claims

1. A method for preparing a Chinese medicine composition for osteoporosis, characterized in that: include: Add 8 times the amount of water as the total amount of medicinal materials into the decoction container and heat to boiling; Add Eucommia ulmoides, Morinda officinalis and Rhizoma Cibotii into the decoction container, and decoct over low heat for 30 minutes; Add Rehmannia root, Astragalus root, Cornus officinalis, Alisma orientalis and Poria cocos into the decoction container, and continue to decoct for 40 minutes; Adding epimedium and angelica to the decoction container, decoct for 10 minutes and then filter, leaving the residue in the decoction container; Add 6 times the amount of water as the total amount of the medicinal materials into the decoction container, heat to boiling, turn to low heat and decoct for 40 minutes, then filter; The decoctions from the two decoctions were combined, filtered through double-layer gauze, and concentrated to 300 ml to obtain a traditional Chinese medicine composition.

2. The method for preparing the osteoporosis nursing Chinese medicine composition according to claim 1, characterized in that: The main drugs of the traditional Chinese medicine composition are Eucommia ulmoides and Rehmannia glutinosa, the auxiliary drugs are Epimedium brevicornum, Cornus officinalis, Angelica sinensis, Alismatis orientalis, Millennium scutellariae, Poria cocos and Morinda officinalis, and the adjuvant drug is Astragalus membranaceus.

3. The method for preparing the osteoporosis-treating Chinese medicine composition according to claim 2, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 8-12g of Eucommia ulmoides, 13-17g of Rehmannia glutinosa, 25-35g of Astragalus membranaceus, 8-12g of Epimedium, 8-12g of Cornus officinalis, 8-12g of Angelica sinensis, 8-12g of Alismatis orientalis, 8-12g of Poria, 8-12g of Centella asiatica, and 8-12g of Morinda officinalis.

4. The method for preparing the osteoporosis-treating Chinese medicine composition according to claim 3, characterized in that: The Chinese medicine composition comprises the following components in parts by weight: 10g of Eucommia ulmoides, 15g of Rehmannia glutinosa, 30g of Astragalus membranaceus, 10g of Epimedium, 10g of Cornus officinalis, 10g of Angelica sinensis, 10g of Alismatis orientalis, 10g of Poria, 10g of Centella asiatica, and 10g of Morinda officinalis.

5. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 3, characterized in that: The mass ratio of Eucommia ulmoides and Rehmannia glutinosa is 1:1.3-1.

7.

6. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 3, characterized in that: The mass ratio of epimedium and rehmannia root is 1:1.3-1.

7.

7. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 1, characterized in that: The density of the Chinese medicine composition is 1.1-1.5 g / cm 3 .

8. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 1, characterized in that: The concentration process of the decoction includes heating under reduced pressure to evaporate water to obtain a Chinese medicine composition, wherein the pressure is no more than 188 mmHg and the evaporation temperature is 35-65°C.

9. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 1, characterized in that: The shelf life of the traditional Chinese medicine composition is 7 days and the refrigerated temperature is 2-5°C.

10. The method for preparing the osteoporosis-treating Chinese medicinal composition according to claim 1, characterized in that: The Chinese medicine composition is taken in the form of one dose a day, divided into three doses and then diluted with water for taking.

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