Skin external preparation composition and application

Abstract

The invention relates to a skin external preparation composition and application. The skin external preparation composition is prepared from natural colored grease, benzotriazolyl dodecyl p-cresol and glucosylrutin, the mass ratio of the benzotriazolyl dodecyl p-cresol to the glucosylrutin is 1 to (0.2 to 4); the mass percent of the benzotriazolyl dodecyl p-cresol in the skin external preparation composition is greater than or equal to 0.005%; the mass percent of the glucosylrutin in the skin external preparation composition is greater than or equal to 0.01%. The skin external preparation composition can effectively improve the light stability of natural colored grease.

Description

Technical Field

[0001] The present application relates to the technical field of cosmetics, and particularly to a topical skin agent composition and its application. Background Art

[0002] In order to make cosmetics present a more attractive appearance, the color of cosmetic formulations is usually adjusted. At the same time, in view of consumers' demand for natural products, many cosmetic formulations use natural oils with colors, especially oils in yellow, orange-yellow, orange-red, and golden-yellow colors. Such natural colored oils can make the formulation body present an appearance with a pleasant natural feeling. However, the color of natural colored oils is very unstable and will fade quickly when exposed to light and oxygen, posing a great challenge to the stability of the formulation.

[0003] There is a method providing the use of benzotriazole derivatives for photo-stabilization, which improves the photo-stability of cosmetics with organic UV absorbers, that is, enhances the photo-stability of UV absorbers (sunscreen agents). The effect on the stability of natural colored oils is unknown. In addition, the addition amount of its benzotriazole derivatives is relatively high, which is a relatively big challenge for skin safety and formulation naturalness.

[0004] There is also a method providing an oil-control composition for improving the photo-stability of ergothioneine and its application. This oil-control composition combines ergothioneine with two components, glucosyl rutin and semen vaccariae extract, which can significantly improve the photo-stability of ergothioneine. The photo-instability of ergothioneine is related to trimethylamine in its structure, and this composition is water-soluble. The effect on the stability of oily colored active ingredients is unknown. Summary of the Invention

[0005] Based on this, the present application provides a topical skin agent composition and its application that can effectively improve the photo-stability of natural colored oils.

[0006] In the first aspect of the present application, there is provided a topical skin agent composition, including natural colored oil, benzotriazolyl dodecyl p-cresol, and glucosyl rutin; the mass ratio of benzotriazolyl dodecyl p-cresol to glucosyl rutin is 1:(0.2 - 4);

[0007] The mass percentage of benzotriazolyl dodecyl p-cresol in the topical skin agent composition ≥ 0.005%;

[0008] The mass percentage of glucosyl rutin in the topical skin agent composition ≥ 0.01%.

[0009] In some embodiments, the mass percentage of benzotriazolyl dodecyl p-cresol in the topical skin agent composition is 0.005% - 0.09%.

[0010] In some of these embodiments, the mass percentage of glucosyl rutin in the topical skin agent composition is 0.01% to 0.1%.

[0011] In some of these embodiments, the natural colored oil includes one or more of seabuckthorn oil, oat kernel oil, brazilwood seed oil, carrot seed oil, carrot root extract, β-carotene, and Mauritia flexuosa fruit oil.

[0012] In some of these embodiments, the topical skin agent composition is a water-oil biphasic system, where the oil phase is emulsified or suspended in the water phase in particle form, the benzotriazolyl dodecyl p-cresol and the natural colored oil are located in the oil phase, and the glucosyl rutin is located in the water phase;

[0013] Optionally, the particle size of the oil phase is 1 μm to 4 mm.

[0014] In some of these embodiments, the oil phase is suspended in the water phase in particle form. Optionally, the particle size of the oil phase is 0.5 mm to 4 mm.

[0015] In some of these embodiments, the oil phase further includes a rheology modifier, and the mass percentage of the rheology modifier in the oil phase is 2.5% to 10%.

[0016] In some of these embodiments, the rheology modifier includes one or more of castor oil / isophorone diisocyanate (IPDI) copolymer, hexamethylene diisocyanate (HDI) / trimethylolhexyl lactone cross-linked polymer, dibutyl lauroyl glutamine, and dibutyl ethylhexanoyl glutamine.

[0017] In some of these embodiments, the oil phase further includes emollient oil; and / or

[0018] The water phase further includes one or more of a humectant, a preservative, a thickener, a chelating agent, a fragrance, and a pigment.

[0019] In a second aspect of the present application, there is provided the use of benzotriazolyl dodecyl p-cresol and glucosyl rutin as light stabilizers in the preparation of a topical skin agent. Optionally, the topical skin agent contains natural colored oil.

[0020] The present application unexpectedly discovers that adding benzotriazolyl dodecyl p-cresol and glucosyl rutin to a topical skin agent containing natural colored oil can well protect the color stability of the preparation. Especially when applied in a water-oil biphasic system, it can well maintain the natural color appearance and the transparency of the oil particles, providing a new idea for the formulation stability.

[0021] In addition, the present application also found that benzotriazolyl dodecyl p-cresol and glucosyl rutin can achieve good light stability effects with extremely small dosages, and have very good synergistic effects. Description of the Drawings

[0022] Figure 1 Appearance diagrams of the topical skin agents prepared in Examples 1-7.

[0023] Figure 2 Appearance diagrams of the topical skin agents prepared in Comparative Examples 1-7.

[0024] Figure 3 Appearance comparison diagrams of the topical skin agent prepared in Example 1 at room temperature and after xenon lamp irradiation.

[0025] Figure 4 Appearance comparison diagrams of the topical skin agent prepared in Example 2 at room temperature and after xenon lamp irradiation.

[0026] Figure 5 Appearance comparison diagrams of the topical skin agent prepared in Example 3 at room temperature and after xenon lamp irradiation.

[0027] Figure 6 Appearance comparison diagrams of the topical skin agent prepared in Example 4 at room temperature and after xenon lamp irradiation.

[0028] Figure 7 Appearance comparison diagrams of the topical skin agent prepared in Example 5 at room temperature and after xenon lamp irradiation.

[0029] Figure 8 Appearance comparison diagrams of the topical skin agent prepared in Example 6 at room temperature and after xenon lamp irradiation.

[0030] Figure 9 Appearance comparison diagrams of the topical skin agent prepared in Example 7 at room temperature and after xenon lamp irradiation.

[0031] Figure 10 Appearance comparison diagrams of the topical skin agent prepared in Comparative Example 1 at room temperature and after xenon lamp irradiation.

[0032] Figure 11 Appearance comparison diagrams of the topical skin agent prepared in Comparative Example 2 at room temperature and after xenon lamp irradiation.

[0033] Figure 12 Appearance comparison diagrams of the topical skin agent prepared in Comparative Example 3 at room temperature and after xenon lamp irradiation.

[0034] Figure 13 Appearance comparison diagrams of the topical skin agent prepared in Comparative Example 4 at room temperature and after xenon lamp irradiation.

[0035] Figure 14Appearance comparison diagram of the topical skin agent prepared in Comparative Example 5 at room temperature and after xenon lamp irradiation.

[0036] Figure 15 Appearance comparison diagram of the topical skin agent prepared in Comparative Example 6 at room temperature and after xenon lamp irradiation.

[0037] Figure 16 Appearance comparison diagram of the topical skin agent prepared in Comparative Example 7 at room temperature and after xenon lamp irradiation. Detailed implementation manners

[0038] The following further describes in detail the topical skin agent composition of the present application, its preparation method and application in combination with specific examples. The present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosed content of the present application more thorough and comprehensive.

[0039] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the technical field to which this application belongs. The terms used in the description of the present application herein are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0040] The optional range of the terms "and / or", "or / and", "and / or" used herein includes any one of two or more related listed items, and also includes any and all combinations of the related listed items. The said any and all combinations include any two related listed items, any more related listed items, or the combination of all related listed items.

[0041] Herein, "one or more" refers to any one, any two or any two or more of the listed items.

[0042] In the present application, "the first aspect", "the second aspect", etc. are only for descriptive purposes and cannot be understood as indicating or implying relative importance or quantity, nor can they be understood as implicitly indicating the importance or quantity of the indicated technical features. Moreover, "the first", "the second", etc. only serve the purpose of non-exhaustive listing and description, and it should be understood that they do not constitute a closed limitation on quantity.

[0043] In the present application, among the technical features described in an open-ended manner, a closed technical solution composed of the listed features is included, and an open technical solution including the listed features is also included.

[0044] In this application, when it comes to numerical ranges, unless otherwise specified, the above numerical ranges are considered continuous and include the minimum and maximum values of the range, as well as each value between such minimum and maximum values. Further, when the range refers to integers, it includes each integer between the minimum and maximum values of the range. In addition, when multiple ranges are provided to describe features or characteristics, the ranges can be combined. In other words, unless otherwise indicated, all ranges disclosed herein should be understood to include any and all sub-ranges subsumed therein.

[0045] In this application, the percentage content involved, unless otherwise specified, refers to the mass percentage for solid-liquid mixtures and solid-solid mixtures, and refers to the volume percentage for liquid-liquid mixtures.

[0046] In this application, the percentage concentration involved, unless otherwise specified, refers to the final concentration. The final concentration refers to the proportion of the added component in the system after adding the component.

[0047] In this application, the temperature parameter, unless otherwise specified, allows for both constant temperature treatment and treatment within a certain temperature range. The constant temperature treatment allows the temperature to fluctuate within the accuracy range controlled by the instrument.

[0048] Normal temperature in this application generally refers to 4°C to 30°C, preferably 20 ± 5°C.

[0049] In some examples of this application, a topical skin agent composition is provided, which includes natural colored oils, benzotriazolyl dodecyl p-cresol, and glucosyl rutin; the mass ratio of benzotriazolyl dodecyl p-cresol to glucosyl rutin is 1:(0.2 - 4); the mass percentage of benzotriazolyl dodecyl p-cresol in the topical skin agent composition is ≥ 0.005%; the mass percentage of glucosyl rutin in the topical skin agent composition is ≥ 0.01%.

[0050] Without limitation, benzotriazolyl dodecyl p-cresol is an oily liquid, which is convenient for mixing with various oils, especially natural colored oils such as seabuckthorn oil, oat kernel oil, padauk oil, carrot seed oil, carrot root extract, β-carotene, and Mauritia flexuosa fruit oil, which are oils with a certain polarity. Natural colored oils have a certain ultraviolet absorption ability. The structures containing conjugated, phenolic hydroxyl, and carbonyl groups all have the ability to absorb ultraviolet light. Under the action of ultraviolet light, the active groups change, resulting in a change in color. Benzotriazolyl dodecyl p-cresol has a certain absorbability in both the UVB and UVA ultraviolet bands, but there is still a gap in the absorption ability compared with traditional sunscreens.

[0051] Glucosyl rutin has a sugar group attached to the rutin molecule, so its solubility in water is greatly increased. It has a certain ability to absorb ultraviolet rays in the UVA band, but there is a large gap compared with the absorption ability of traditional sunscreen agents.

[0052] In summary, although the physical and chemical properties of benzotriazolyl dodecyl p-cresol and glucosyl rutin are different, their combination has an unexpected additive effect on the protection of the color of skin topical agents containing natural colored oils.

[0053] Without limitation, the mass percentage includes but is not limited to: the mass ratio of the benzotriazolyl dodecyl p-cresol to glucosyl rutin includes but is not limited to: 1:0.2, 1:0.22, 1:0.25, 1:0.3, 1:0.5, 1:0.8, 1:1, 1:1.5, 1:2, 1:2.5, 1:3, 1:3.5, 1:4 or the range between any two of the foregoing.

[0054] Furthermore, benzotriazolyl dodecyl p-cresol and glucosyl rutin can still exert a significant protective effect on the color of the dosage form at extremely low dosages, and at the same time, it also has a significant effect on maintaining the transparency of the water-oil two-phase transparent system under light and heat conditions. It can be understood that more dosages can still achieve a good light stability effect, but the practical application value is not great and the cost will be increased.

[0055] In some examples, the mass percentage of the benzotriazolyl dodecyl p-cresol in the skin topical agent composition is 0.005% to 0.09%. Without limitation, the mass percentage includes but is not limited to: 0.005%, 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05%, 0.055%, 0.06%, 0.065%, 0.07%, 0.075%, 0.08%, 0.085%, 0.09% or the range between any two of the foregoing.

[0056] In some examples, the mass percentage of the glucosyl rutin in the skin topical agent composition is 0.01% to 0.1%. Without limitation, the mass percentage includes but is not limited to: 0.01%, 0.015%, 0.02%, 0.025%, 0.03%, 0.035%, 0.04%, 0.045%, 0.05%, 0.055%, 0.06%, 0.065%, 0.07%, 0.075%, 0.08%, 0.085%, 0.09%, 0.095%, 0.1% or the range between any two of the foregoing.

[0057] Without limitation, the natural colored oil includes one or more of seabuckthorn oil, oat kernel oil, redwood seed oil, carrot seed oil, carrot root extract, β-carotene, and Mauritia flexuosa fruit oil.

[0058] Without limitation, the usage amount of the natural colored oil is based on the color acceptance or design of the final product. In some examples, the mass percentage of the natural colored oil in the topical skin care composition is 0.0001% to 5%. Without limitation, the mass percentage includes but is not limited to: 0.0001%, 0.0003%, 0.00035%, 0.0005%, 0.0007%, 0.0001%, 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, 0.35%, 0.4%, 0.45%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, or the range between any two of the foregoing.

[0059] Furthermore, in traditional methods, there are mainly two ways to solve the stability problem of natural colored oils: 1) To maintain the natural feeling, a pure oil system is made, and the photothermal stability of the formulation is improved by adding antioxidants such as natural vitamin E or plant oils with antioxidant activity. This method is only suitable for pure oil systems and cannot achieve color stability in systems with a high water content; 2) Adding some sunscreen agents and antioxidants in the water-containing system can also improve color stability to a large extent, but this method will inevitably introduce a high content of chemical sunscreen agents, which is contrary to the natural intention. The above solutions have limitations on both the dosage form and the formulation, and it is difficult to meet the product design requirements. Especially for the currently very popular oil bead suspension system, in this system, the oil phase is rheologically modified, and the oil phase is stably suspended in the transparent aqueous solution in the form of particles, presenting visible oily particles at room temperature, giving consumers a feeling of naturalness, purity, and high efficacy. In order to make the product more natural, natural colored oil is generally added to the oil particles to make them present a colored appearance. However, the color of the oil particles is easily faded under the action of light and oxygen, and at the same time, the rheological modifier in the oil particles is easily changed when exposed to light and heat, resulting in a decrease in the transparency of the particles and a turbid state. The above-mentioned composition provided by the present application is particularly suitable for water-oil biphasic systems to improve the light stability of natural colored oils.

[0060] In some of these examples, the topical skin agent composition is a water-oil biphasic system, where the oil phase is emulsified or suspended in the water phase in the form of particles. The benzotriazolyl dodecyl p-cresol and the natural colored oil are located in the oil phase, and the glucosyl rutin is located in the water phase. In this way, the oil solubility of benzotriazolyl dodecyl p-cresol can be miscible with the natural colored oil, and the water solubility of glucosyl rutin can be protected in the water phase. Benzotriazolyl dodecyl p-cresol and glucosyl rutin are dissolved in the water and oil phases respectively, which can well synergistically protect the color stability of the water-oil biphasic dosage form.

[0061] In addition, in order to present the special appearance of the topical skin agent or for the protection of the activity of the oil-soluble active ingredient, in the water-oil biphasic system, in addition to making an oil-in-water emulsion system, a formulation system (oil bead suspension system) in which the oil phase is suspended in the water phase in the form of particles can also be made. Compared with the emulsion system, the oil phase in this system has a larger particle size and thus has a visual appearance.

[0062] Without limitation, the oil-in-water emulsion system is emulsified by an emulsifier or high-energy mechanical force. The oil particles in the emulsion itself have a relatively small particle size, usually between 1 μm and 100 μm, and the appearance is often milky white. In the formulation system in which the oil phase is suspended in the water phase in the form of particles, the particle size of the oil phase is 1 μm to 4 mm for the oil particles. Especially when the oil particles are in a transparent state, the particle size is 0.5 mm to 4 mm. Without limitation, the particle size of the oil phase includes but is not limited to: 0.5 mm, 0.53 mm, 0.55 mm, 0.89 mm, 0.95 mm, 0.96 mm, 1.12 mm, 1.5 mm, 2 mm, 2.5 mm, 3 mm, 3.58 mm, 4 mm or the range between any two of the foregoing.

[0063] In the oil-in-water emulsion system, due to the relatively small particle size of the oil phase, the formulation is milky, which will reduce the color development of the natural colored components while also having a certain light protection property because the emulsion is opaque. In the formulation system in which the oil phase is suspended in the water phase in the form of particles, especially when the oil phase is suspended in the water phase with a relatively large particle size (0.5 mm to 4 mm), it is easier to observe the changes in the color and state of the oil phase. When both the water phase and the oil phase are in a transparent state, the requirements for the color and state stability of the formulation are more stringent, and at this time, the protective performance of the composition of the present application can be more reflected.

[0064] Furthermore, in order to obtain visualizable oil particles, it is usually necessary to use rheological modifiers. In some of these examples, the rheological modifiers include one or more of castor oil / isophorone diisocyanate (IPDI) copolymer, hexamethylene diisocyanate (HDI) / trimethylolhexyl lactone crosslinked polymer, dibutyl lauroyl glutamine, and dibutyl ethylhexanoyl glutamine. Such rheological modifiers can endow the oil phase with a certain viscosity and yield value. In order to highlight the crystal-clear appearance of the oil particles, natural colored oils are used to color the oil phase particles.

[0065] In addition, when preparing a biphasic system containing oil particles, it is also necessary to use oils, especially when the oil particles to be prepared have good transparency, it is necessary to select emollient oils that are liquid at room temperature.

[0066] Without limitation, the emollient oils can be selected from at least one of fatty acid esters, carbonates, long-chain alkanes, long-chain alkyl ethers, fatty alcohol ethers, glycerol esters, mineral oils, silicone oils, and vegetable oils. Further, the oils are selected from esters of straight-chain C6-C22 fatty acids and straight-chain or branched C6-C22 fatty alcohols or esters of branched C6-C13 carboxylic acids and straight-chain or branched C6-C22 fatty alcohols, such as myristyl palmitate, myristyl stearate, myristyl isostearate, cetyl myristate, cetyl isostearate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isopropyl myristate, isopropyl palmitate, ethylhexyl palmitate, ethylhexyl myristate, ethylhexyl stearate, hexyl laurate, isoamyl laurate, C12-C15 alkyl benzoate, dibutyl adipate, caprylic / capric triglyceride, propylheptyl octanoate (Cetiol Sensoft), cetearyl isononanoate, isononyl isononanoate, isodecyl isononanoate, and dicaprylyl / dicaprate of propylene glycol. Even further, the oils are selected from at least one of triglycerides based on C6-C10 fatty acids, triglycerides of branched C6-C10 fatty acids, glycerol mono / di / triesters based on C6-C18 fatty acids and mixtures thereof, dicaprylyl carbonate, and diethylhexyl carbonate. Further, the oils are selected from at least one of vegetable oils, C11 alkanes, and C13 alkanes, hydrogenated polyisobutene, and hydrogenated polydecene. Further, the vegetable oils are selected from at least one of sunflower seed oil, castor oil, wheat germ oil, sweet almond oil, wild soybean oil, sunflower seed oil, sesame seed oil, corn oil, macadamia nut oil, olive oil, Limnanthes alba seed oil, peony seed oil, evening primrose oil, rice bran oil, camellia seed oil, and rapeseed oil.

[0067] In addition, the amount of the rheology modifier is mainly aimed at ensuring the formation of oil particles, and the state of the particles should not change significantly after the particles are formed. In addition, the convenience of process operation can also be taken into account. In some of these examples, the mass percentage of the rheology modifier in the oil phase is 2.5% to 10%. Without limitation, this mass percentage includes but is not limited to: 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10% or the range between any two of the foregoing.

[0068] Generally speaking, in topical skin preparations, the oil phase content in traditional water-oil biphasic dosage forms or oil-in-water dosage forms does not exceed 35% of the total weight. Especially in the water-oil biphasic oil suspension system, in order to present an exquisite appearance, the content of the oil phase generally does not exceed 25% of the total weight. It has been found in this application that when benzotriazolyl dodecyl p-cresol and glucosyl rutin are used in combination, a very low addition amount has a good effect. The addition amount of benzotriazolyl dodecyl p-cresol in the formulation is as low as 0.005%, and at the same time, in combination with glucosyl rutin as low as 0.01%, it can protect a water-oil biphasic system with a highly colored oil phase of up to 20% to 30%.

[0069] In summary, through the combination of emollient oils, rheology modifiers, and natural colored oils, the oil phase particles can have specific sizes and specific appearances. In addition, in addition to the oils and oil phase rheology modifiers necessary to obtain the oil phase particles, the aqueous phase can also include humectants, thickeners, auxiliaries (such as chelating agents, fragrances, pigments), preservatives, etc.

[0070] Among them, the thickener can be selected from acrylic polymers such as carbomer, acrylate / C10-30 alkanol acrylate cross-linked polymer, or homopolymers with monomers in methacrylic acid, acrylic acid, methacrylate, acrylate, methacrylamide, and acrylamide as the constituent units, such as polyacrylamide (SEPIGEL 305) from SEPPIC, sodium acrylate / sodium acryloyldimethyl taurate copolymer (SIMULGEL EG), hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer (SIMULGEL FL, SIMULGEL NS, SEPIPLUS S, SEPINOV EMT 10), polyacrylate-13 (SEPIPLUS 400), etc., or polymers with monomers of dimethylacrylamide, acrylic acid, N-vinylpyrrolidone, acrylamide-2-methyl taurate, and ethoxylated fatty alcohol methacrylate as the unit constituents, such as ammonium acryloyldimethyltaurate / VP copolymer (Aristoflex AVC) from CLARIANT, polyacrylate cross-linked copolymer-11 (Aristoflex Velvet), ammonium acryloyldimethyltaurate / behenyl ether-25 methacrylate cross-linked polymer (Aristoflex BLV, Aristoflex HMB), sodium polyacryloyldimethyltaurate (Aristoflex SILK), etc.

[0071] The humectant can be selected from polyhydric alcohols, amino acids, and hydrophilic substances such as polyethylene glycols that can be dissolved or dispersed in water. Such substances provide moisture retention for the skin preparation while enhancing the stability of the formulation, such as glycerol, propylene glycol, 1,3-propanediol, 1,3-butanediol, betaine, trehalose, hydrogenated starch hydrolysate, glycosyl trehalose, glycerol polyether-26, methyl glucoside polyether-10, methyl glucoside polyether-20, glycerol glucoside, etc.

[0072] The use of auxiliaries and preservatives is to maintain the stability of the formulation or the anti-corrosion effectiveness. The auxiliaries can include chelating agents, fragrances, pigments, etc. Raw materials that can be used in cosmetics can all be used in the skin topical preparation of this application.

[0073] In some other examples of this application, the use of benzotriazolyl dodecyl p-cresol and glucosyl rutin as light stabilizers in the preparation of a light-stable skin topical agent is also provided. Optionally, the skin topical agent contains natural colored oils.

[0074] It can be understood that in this application, "light-stable" means that the natural colored oils in the skin topical agent do not show phenomena such as color change and turbidity under light.

[0075] For the experimental parameters not specified in the following specific examples, priority shall be given to the guidance provided in this application document. Reference can also be made to the experimental manuals in this field or other experimental methods known in this field, or the experimental conditions recommended by the manufacturers.

[0076] The raw materials and reagents involved in the following specific examples can be obtained commercially, or can be prepared by those skilled in the art according to known means.

[0077] In the examples, the particle size of the oily particles was measured using a digital caliper. Twenty particles were randomly selected from each example and their average value was measured.

[0078] Light stability test method (xenon lamp irradiation method): Place the sample in a xenon lamp aging test machine for 8 h. After the test is completed, compare the appearance with the sample at room temperature. The model of the xenon lamp aging test machine is Q-SUN Xe 3H. The test simulates strong sunlight irradiation, with 3 lamp tubes, a light source wavelength of 420 nm, and an irradiance of 1.1 W / m 2 , the temperature of the box body is 40 °C, the black and white temperature is 50 °C, and it lasts for 8 h. Place the sample in a transparent PET bottle and put it into the xenon lamp aging chamber for 8 h to examine the changes in the material after light and heat, and test the protection effect of the light-stable composition on the stability of the material.

[0079] The topical skin preparations in the examples and comparative examples all use a water-oil two-phase transparent system, and oil-phase particles of a certain size are uniformly suspended in the water phase. The formula compositions are shown in Tables 1 to 3 below (calculated as the mass percentage of the topical skin preparation).

[0080] The examples and comparative examples can be prepared using the commonly used preparation processes for topical skin agents, which mainly include the following steps:

[0081] 1) In an oil pan, stir the oil-phase rheology modifier and emollient oil at a temperature above 80 °C until clear and transparent. Then, cool the materials in the oil pan to below 60 °C, add natural colored oil and benzotriazolyl dodecyl p-cresol, and stir until uniform for standby;

[0082] 2) At room temperature, in a water pan, mix and dissolve rutin glucoside, humectant, preservative, thickener, auxiliary agent and water in the water phase until transparent;

[0083] 3) Slowly add the materials in the oil pan to the water pan, and stop stirring when distinct oil beads are formed to obtain a transparent system with oil particles uniformly suspended in the water phase.

[0084] Among them, in Examples 1 to 7, the types or mass percentages of the oil-phase rheology modifier, emollient oil, natural colored oil, and light-stable composition are mainly changed. The formula compositions are shown in Table 1 below:

[0085] Table 1

[0086]

[0087]

[0088] Note: Carbomer is CARBOPOL 981 Polymer of Lubrizol Corporation; castor oil / IPDI copolymer is Estogel M of POLYMEREXPERT PRESENTS; COSMETIC GRADE ANNATTO OIL is a mixture of sunflower (HELIANTHUS ANNUUS) seed oil, wild soybean (GLYCINE SOJA) oil, bixa orellana seed oil, and tocopherol (vitamin E) of CLARIANT Corporation.

[0089] Examples 8 and 9 mainly changed the dosage of the oil phase rheology modifier to investigate the effect of the oil phase rheology modifier on the morphology of oil phase particles in the system. The formulation compositions are shown in Table 2 below:

[0090] Table 2

[0091]

[0092] Comparative Examples 1-7 mainly changed the dosage and type of the light stabilizer composition. The formulation compositions are shown in Table 3 below:

[0093] Table 3

[0094]

[0095]

[0096] In addition, the appearances of the topical skin preparations prepared in the examples and comparative examples are as Figure 1 and Figure 2 shown. The comparison diagrams of the appearances of the topical skin preparations prepared in the examples and comparative examples at room temperature and after xenon lamp irradiation are as Figures 3 to 16 shown.

[0097] From the results in Table 1 and Table 2, it can be seen that for the topical skin preparation prepared in the example, as an oil particle suspension in water phase system that can significantly observe the appearances of the water and oil phases, the light stabilizer composition can well improve the stability of the natural colored oils and fats in the formulation even at a low dosage, and maintain the transparency of the oil phase in the formulation, protecting the stability of the oils and fats and polymers in the oil phase.

[0098] Comparative light irradiation diagrams of the topical skin preparations prepared in Example 3 and Comparative Example 1 ( Figure 5 and Figure 10) It can be seen that when there is no benzotriazolyl dodecyl p - cresol, although the formulation can still present a light orange - yellow appearance after light exposure, the particles become significantly hazy. Especially for the upper - layer particles that receive a greater light intensity, the particles become hazier and whiter. The light - exposure comparison diagrams of the topical skin agents prepared in Example 3 and Comparative Example 2( Figure 5 and Figure 11 ) It can be seen that when there is no glucosyl rutin, although the transparency of the oily particles in the formulation still remains good after light exposure, the color of the formulation completely fades. The light - exposure comparison diagrams of the topical skin agents prepared in Example 3 and Comparative Example 6( Figure 5 and Figure 15 ) It can be seen that when there is no light - stable composition in the topical skin agent, after light exposure, the color in the formulation completely fades, and at the same time, the particles become opaque. Especially in the areas where the upper layer receives more light, the particles become hazier and whiter. At the same time, we also found that for topical skin agents using unstable natural yellow oils such as carotene, without light exposure, the color will also gradually fade when placed at room temperature. The light - exposure comparison diagrams of the topical skin agents prepared in Example 6 and Comparative Example 3( Figure 8 and Figure 12 ) It can be seen that when the addition amount of the light - stable composition in the topical skin agent formulation is lower than the scope of this application, its light - protection effect is poor, and it cannot well protect the color and the transparency of the oil phase. The light - exposure comparison diagrams of the topical skin agents prepared in Example 3 and Comparative Example 4( Figure 5 and Figure 13 ) It can be seen that when the mass ratio of benzotriazolyl dodecyl p - cresol to glucosyl rutin in the formulation is greater than the scope of this application, the color - retention effect is not ideal. The light - exposure comparison diagrams of the topical skin agents prepared in Example 3 and Comparative Example 5( Figure 5 and Figure 14 ) It can be seen that when the mass ratio of benzotriazolyl dodecyl p - cresol to glucosyl rutin in the formulation is less than the scope of this application, the oil - phase transparency - retention effect is not ideal. The light - exposure comparison diagrams of the topical skin agents prepared in Example 3 and Comparative Example 7( Figure 5 and Figure 16 ) It can be seen that when using the common water - soluble UV absorber benzophenone - 4 to replace glucosyl rutin, the light - protection effect is significantly worse, and the color of the formulation becomes significantly lighter after light exposure, indicating that the combination of glucosyl rutin and benzotriazolyl dodecyl p - cresol has a better synergistic effect on light stability.

[0099] In addition, by comparing Example 3 with Example 8 and Example 9, it can be seen that the topical skin agent system of the oil - particle suspension aqueous agent has specific requirements for the dosage of the rheology modifier in the oil phase. Beyond the optimal scope in this application, it is difficult to form oily particles, and thus it is difficult to form an aesthetic appearance of colored oil - particle suspension.

[0100] The technical features of the above-described embodiments can be combined arbitrarily. For the sake of brevity of description, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, it should be considered as falling within the scope described in this specification.

[0101] The above-described embodiments merely represent several implementation manners of the present application, which are convenient for understanding the technical solutions of the present application specifically and in detail, but should not be construed as a limitation on the scope of patent protection of the application. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present application, several modifications and improvements can still be made, and these all belong to the protection scope of the present application. It should be understood that the technical solutions obtained by those skilled in the art based on the technical solutions provided in the present application through logical analysis, reasoning or limited experiments are all within the protection scope of the appended claims of the present application. Therefore, the protection scope of the patent of the present application shall be subject to the content of the appended claims, and the description can be used to interpret the content of the claims.

Claims

1. A composition for external use on skin, characterized in that: The invention comprises natural colored oil, benzotriazolyl dodecyl p-cresol and glucosyl rutin; the mass ratio of the benzotriazolyl dodecyl p-cresol to glucosyl rutin is 1:(0.2-4); The mass percentage of the benzotriazolyl dodecyl p-cresol in the skin external preparation composition is ≥ 0.005%; The mass percentage of the glucosylrutin in the skin external preparation composition is ≥ 0.01%.

2. The composition for external use on skin according to claim 1, characterized in that The mass percentage of the benzotriazolyl dodecyl p-cresol in the skin external preparation composition is 0.005% to 0.09%.

3. The composition for external use on skin according to claim 1, characterized in that The mass percentage of the glucosylrutin in the skin external preparation composition is 0.01% to 0.1%.

4. The composition for external use on skin according to claim 1, characterized in that The natural colored oils include one or more of sea buckthorn oil, oat kernel oil, annatto seed oil, carrot seed oil, carrot root extract, beta-carotene and lily palm fruit oil.

5. The composition for external use on skin according to any one of claims 1 to 4, characterized in that The skin topical composition is a water-oil biphase, the oil phase is emulsified or suspended in the water phase in a particle state, the benzotriazolyl dodecyl p-cresol and the natural color oil are located in the oil phase, and the glucosyl rutin is located in the water phase; Optionally, the particle size of the oil phase is 1 μm to 4 mm.

6. The composition for external use on skin according to claim 5, characterized in that The oil phase is suspended in the water phase in a particle state. Optionally, the particle size of the oil phase is 0.5 mm to 4 mm.

7. The composition for external use on skin according to claim 6, characterized in that: The oil phase further comprises a rheology modifier, and the mass percentage of the rheology modifier in the oil phase is 2.5% to 10%.

8. The composition for external use on skin according to claim 7, characterized in that The rheology modifier includes one or more of castor oil / isophorone diisocyanate copolymer, hexamethylene diisocyanate / trimethylol hexyl lactone cross-linked polymer, dibutyl lauroyl glutamide and dibutyl ethylhexanoyl glutamide.

9. The composition for external use on skin according to any one of claims 6 to 8, characterized in that: The oil phase also includes emollients; and / or The aqueous phase also includes one or more of a humectant, a preservative, a thickener, a chelating agent, a flavor and a pigment.

10. Use of benzotriazolyl dodecyl p-cresol and glucosyl rutin as light stabilizers in the preparation of a skin topical preparation, optionally comprising natural colored oils and fats.

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