Application of peach gum polysaccharide in preparation of product for protecting skin from heavy metal damage

Abstract

The invention belongs to the technical field of biology, and particularly relates to application of peach gum polysaccharide to preparation of a product for protecting skin from heavy metal damage. The invention relates to the field of skin care, in particular to application of peach gum polysaccharide in preparation of skin care products and / or cosmetics for preventing and / or repairing skin heavy metal damage. The invention provides application of peach gum polysaccharide in preparation of a product for preventing and / or repairing heavy metal injury of individual skin. The applicant creatively discovers that peach gum polysaccharide has a very good effect in preventing and / or repairing individual skin heavy metal injury, and the survival rate of injured cells caused by heavy metal can be remarkably improved.

Description

Technical Field

[0001] The present invention belongs to the field of biotechnology. Specifically, it relates to the use of peach gum polysaccharide in the preparation of products for protecting the skin from heavy metal damage; more specifically, it relates to the use of peach gum polysaccharide in the preparation of skin care products and / or cosmetics for preventing and / or repairing skin heavy metal damage. Background Art

[0002] Heavy metal ions such as Ni 2+ and Pb 2+ can enter the human body through various channels, cause damage to cells, and affect the functions and survival of cells. These heavy metal ions can interfere with the normal metabolic processes of cells, leading to adverse consequences such as oxidative stress and apoptosis. Specifically, for example, heavy metal ions induce the generation of free radicals, damage skin cells, and at the same time, they can also bind to some proteins, interfere with enzyme activities, and cause inflammation. Therefore, there is a problem of skin damage caused by heavy metals.

[0003] Currently, although there are some chemical drugs that can be used to reduce the toxicity of heavy metal ions and thus treat skin damage caused by heavy metals, these drugs often have side effects. For example, hormonal drugs (such as glucocorticoids). Therefore, there is a need in the art for a product that can effectively protect the skin from heavy metal damage and is derived from natural sources with few side effects. Summary of the Invention

[0004] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a product that can effectively protect the skin from heavy metal damage, and at the same time, this product can minimize the safety risks.

[0005] In view of this, the present invention provides the use of peach gum polysaccharide in the preparation of products for preventing and / or repairing heavy metal damage to the skin of an individual.

[0006] The applicant has creatively found that peach gum polysaccharide has a good effect in preventing and / or repairing heavy metal damage to the skin of an individual, and it can significantly improve the survival rate of cells damaged by heavy metals.

[0007] In some specific embodiments, the final concentration of the peach gum polysaccharide in the product is 10 - 400 μg / mL. Exemplarily, the final concentrations are 10 μg / mL, 50 μg / mL, 100 μg / mL, 150 μg / mL, 200 μg / mL, 250 μg / mL, 300 μg / mL, 350 μg / mL, 400 μg / mL. Preferably, the final concentration of the peach gum polysaccharide in the product is 10 - 300 μg / mL. Preferably, the final concentration of the peach gum polysaccharide in the product is 100 - 300 μg / mL. More preferably, the final concentration of the peach gum polysaccharide in the product is 200 μg / mL.

[0008] In some specific embodiments, the final concentration of the peach gum polysaccharide in the product is 10-400 μg / g. Exemplarily, the final concentrations are 10 μg / g, 50 μg / g, 100 μg / g, 150 μg / g, 200 μg / g, 250 μg / g, 300 μg / g, 350 μg / g, 400 μg / g. Preferably, the final concentration of the peach gum polysaccharide in the product is 10-300 μg / g. Preferably, the final concentration of the peach gum polysaccharide in the product is 100-300 μg / g. More preferably, the final concentration of the peach gum polysaccharide in the product is 200 μg / g.

[0009] In some specific embodiments, the individual is a mammal, and the mammals include but are not limited to rats, mice, non-human primates, humans, dogs, cats, horses, cows, sheep, pigs, goats.

[0010] Preferably, the individual is a human.

[0011] In some specific embodiments, the peach gum polysaccharide is extracted by water extraction method, enzymatic hydrolysis method, ultrasonic-assisted method, microwave-assisted method, or supercritical CO2 method. Preferably, the peach gum polysaccharide is extracted by ultrasonic-assisted method, microwave-assisted method, or supercritical CO2 method. More preferably, the peach gum polysaccharide is extracted by ultrasonic-assisted method or supercritical CO2 method.

[0012] Using the ultrasonic-assisted method or supercritical CO2 method can more significantly improve the survival rate of cells damaged by heavy metals.

[0013] In some specific embodiments, the water extraction method includes the following steps:

[0014] Crush the peach gum to obtain the crushed peach gum; mix the crushed peach gum with water; perform constant-temperature water bath stirring extraction after mixing to obtain an extract; centrifuge the extract and collect the supernatant; and process the supernatant to obtain peach gum polysaccharide.

[0015] Further, the material-liquid ratio of the crushed peach gum to water for mixing is 1:(10-50), preferably 1:(10-30), and more preferably 1:20.

[0016] Further, the temperature of the constant-temperature water bath is 50-100 °C, preferably 50-80 °C, and more preferably 80 °C.

[0017] Further, the duration of the stirring extraction is 1-3 hours, preferably 2-3 hours, and more preferably 2 hours.

[0018] In some specific embodiments, the enzymatic hydrolysis method includes the following steps:

[0019] Crush peach gum to obtain crushed peach gum; mix the crushed peach gum with water; after mixing, add cellulase for enzymatic hydrolysis to obtain an enzymatic hydrolysate; and process the enzymatic hydrolysate to obtain peach gum polysaccharide.

[0020] Further, the material-liquid ratio of the crushed peach gum to water for mixing is 1:(10 - 30), preferably 1:(10 - 20), and more preferably 1:15.

[0021] Further, the duration of the enzymatic hydrolysis is 1 - 3 hours, preferably 2 - 3 hours, and more preferably 3 hours.

[0022] In some specific embodiments, the ultrasonic-assisted method comprises the following steps:

[0023] Crush peach gum to obtain crushed peach gum; mix the crushed peach gum with water; after mixing, use an ultrasonic extractor for extraction to obtain an extract; centrifuge the extract and collect the supernatant; and process the supernatant to obtain peach gum polysaccharide.

[0024] Further, the material-liquid ratio of the crushed peach gum to water for mixing is 1:(10 - 30), preferably 1:(10 - 20), and more preferably 1:10.

[0025] Further, the parameters of the ultrasonic extraction are as follows:

[0026] Power: 300 W, Frequency: 40 kHz, Temperature: 60 °C, Time: 30 minutes (Pulse mode: Working for 5 seconds, Intermittent for 2 seconds).

[0027] In some specific embodiments, the microwave-assisted method comprises the following steps:

[0028] Crush peach gum to obtain crushed peach gum; mix the crushed peach gum with water; after mixing, use a microwave reactor for extraction to obtain an extract; centrifuge the extract and collect the supernatant; and process the supernatant to obtain peach gum polysaccharide.

[0029] Further, the material-liquid ratio of the crushed peach gum to water for mixing is 1:(10 - 30), preferably 1:(10 - 20), and more preferably 1:15.

[0030] Further, the parameters of the microwave extraction are as follows:

[0031] Power: 500 W, Temperature: 70 °C, Time: 15 minutes, Pressure: Atmospheric pressure.

[0032] In some specific embodiments, the supercritical CO2 method comprises the following steps:

[0033] Crush the peach gum to obtain the crushed peach gum; mix the crushed peach gum with water; after mixing, use a supercritical CO2 extraction device for extraction to obtain an extract; filter the extract and collect the filtrate; and process the filtrate to obtain peach gum polysaccharide.

[0034] Further, the material-liquid ratio of the crushed peach gum to water for mixing is 1:(10 - 30), preferably 1:(10 - 20), and more preferably 1:10.

[0035] Further, the parameters for the supercritical CO2 extraction are as follows:

[0036] Temperature: 40°C, Time: 2 hours, Pressure: 25 MPa.

[0037] In some specific embodiments, the product is a skin care product.

[0038] In some specific embodiments, the product is a cosmetic.

[0039] In some specific embodiments, the product is a pharmaceutical.

[0040] Further, the skin care product can be a facial cleanser, essence, lotion, emulsion, cream, sunscreen, etc.

[0041] Further, the cosmetic can be makeup, such as a cushion, foundation, loose powder, powder cake, makeup primer, primer, lipstick, blush, contour, eyeshadow, etc.

[0042] As a dosage form that can be used as a cosmetic and / or skin care product, dosage forms such as stick-shaped, dish-shaped, ointment-shaped, etc. can be adopted.

[0043] In the present invention, in the product, in addition to the above components, any components commonly used in cosmetics, skin care products, or pharmaceuticals can also be incorporated. As arbitrary components, the following components can be cited, and as long as the effects of the present invention are exerted, one or more than two can be incorporated.

[0044] In some specific embodiments, the product of the present invention further includes one or more of an emollient, a filler, a colorant, a synthetic wax, a humectant, a preservative, an adhesive, a thickener, or an emulsifier.

[0045] The cosmetic of the present invention can contain any amount of water. As the water, the water used in cosmetics, quasi-drugs, etc. can be used, for example, ion-exchanged water, distilled water, ultrapure water, tap water, etc. can be used.

[0046] In some specific embodiments, the emollient of the present invention can be isononyl isononanoate or octyldodecanol or polyglyceryl-2 triisostearate.

[0047] In some specific embodiments, the filler of the present invention may be one or more of silica, polymethylsilsesquioxane, mica, muscovite, phlogopite, synthetic mica, red mica, or biotite.

[0048] In some specific embodiments, the synthetic wax of the present invention may include beeswax, candelilla wax, cotton wax, carnauba wax, myrica wax, insect wax, spermaceti wax, montan wax, rice bran wax, lanolin, kapok wax, acetylated lanolin, lanolin oil, sugarcane wax, isopropyl lanolate, hexyl laurate, hydrogenated lanolin, jojoba wax, hard lanolin, shellac wax, etc.

[0049] In some specific embodiments, the humectant of the present invention may include polyethylene glycol, propylene glycol, glycerol, 1,3 - butanediol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, sulfomucin, cholesterol - 12 - hydroxystearate, sodium lactate, bile salts, pyrrolidone carboxylate, short - chain soluble collagen, diglycerol PO adduct, yarrow extract, lavender extract, etc.

[0050] In some specific embodiments, the preservatives of the present invention may include parabens such as methyl paraben, ethyl paraben, butyl paraben, benzoic acid, salicylic acid, sorbic acid, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine, triclocarban, photochromes, phenoxyethanol, etc.

[0051] In some specific embodiments, the thickeners of the present invention may include gum arabic, carrageenan, carrageenan, tragacanth gum, locust bean gum, casein, dextrin, gelatin, sodium pectate, sodium alginate, methyl cellulose, ethyl cellulose, CMC, hydroxyethyl cellulose, hydroxypropyl cellulose, PVA, PVM, PVP, sodium polyacrylate, carboxyvinyl polymer, locust bean gum, guar gum, tamarind gum, dialkyldimethylammonium sulfate cellulose, xanthan gum, magnesium aluminum silicate, bentonite, lithium montmorillonite, propolis, silicon anhydride, etc.

[0052] In some specific embodiments, the emulsifiers of the present invention may include non - ionic surfactants, amphiphilic polymers, such as (acrylate / stearyl alcohol polyether - 20) copolymer, hydrophobically modified alkyl cellulose, hydrogenated lecithin, sorbitan laurate, sorbitan palmitate, sorbitan oleate, sorbitan stearate, sorbitan isostearate, sorbitan sesquioleate, sorbitan trioleate, sorbitan tristearate, sorbitan sesquiisostearate. Detailed Description of the Invention

[0053] The present invention will be specifically described below in combination with specific implementation schemes and examples, and the advantages and various effects of the present invention will be presented more clearly therefrom. Those skilled in the art should understand that these specific implementation schemes and examples are used to illustrate the present invention, rather than limiting the present invention.

[0054] The "range" disclosed in this application is defined in the form of a lower limit and an upper limit. A given range is defined by selecting a lower limit and an upper limit, and the selected lower limit and upper limit define the boundary of a specific range. The range defined in this way can include the end values or not include the end values, and can be combined arbitrarily, that is, any lower limit can be combined with any upper limit to form a range.

[0055] In this application, unless otherwise specified, the numerical range "a - b" represents an abbreviated representation of any real number combination between a and b, where both a and b are real numbers. For example, the numerical range "0 - 5" means that all real numbers between "0 - 5" have been fully listed herein, and "0 - 5" is only an abbreviated representation of these numerical combinations. In addition, when it is stated that a certain parameter is an integer ≥2, it is equivalent to disclosing that the parameter is, for example, the integers 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, etc.

[0056] If there is no special instruction, all implementation manners and optional implementation manners of this application can be combined with each other to form a new technical solution. If there is no special instruction, all technical features and optional technical features of this application can be combined with each other to form a new technical solution.

[0057] If there is no special instruction, all steps of this application can be carried out in sequence or randomly, preferably in sequence. For example, the method includes steps (a) and (b), which means that the method can include steps (a) and (b) carried out in sequence, or can also include steps (b) and (a) carried out in sequence. For example, it is mentioned that the method may further include step (c), which means that step (c) can be added to the method in any order. For example, the method can include steps (a), (b) and (c), or can also include steps (a), (c) and (b), or can also include steps (c), (a) and (b), etc.

[0058] The term

[0059] "peach gum polysaccharide" is a viscous resin secreted by the damaged bark of peach trees (natural defense mechanism), and is obtained after drying and purification. Its main chain is mainly composed of galactose connected by β-1,3-glycosidic bonds, and its side chains may contain monosaccharides such as arabinose, rhamnose, glucose, etc., forming a branched structure.

[0060] "Prevention and / or repair" means preventing and / or delaying the onset of a disease or injury, or normalizing it.

[0061] Hereinafter, embodiments of the present application will be described. The embodiments described below are exemplary and are only used to explain the present application and should not be construed as a limitation of the present application. For those techniques or conditions not specified in the embodiments, they shall be carried out according to the techniques or conditions described in the literature in the art or according to the product specifications. For reagents or instruments whose manufacturers are not indicated, they are all conventional products that can be obtained through commercial purchase.

[0062] Example 1: Extraction of peach gum polysaccharide

[0063] Preparation of peach gum extract (T1) by water extraction method

[0064] 1. Raw material pretreatment

[0065] 1.1 Take 500 g of naturally dried peach gum raw material (water content ≤ 8%) and crush it to a particle size passing through a 100-mesh standard sieve (pore size 150 μm) using a high-speed pulverizer (model XX-200).

[0066] 1.2 Seal and store the crushed peach gum powder in a desiccator for later use.

[0067] 2. Water extraction process

[0068] 2.1 Weigh 100 g of peach gum powder and add 2 L of deionized water according to the solid-liquid ratio of 1:20 (w / v), and place it in a glass reaction kettle.

[0069] 2.2 Turn on the constant temperature water bath circulation system, set the temperature to 80 °C, the stirring speed to 300 rpm, and continuously extract for 2 hours.

[0070] 2.3 After the extraction is completed, transfer the mixture to a centrifuge tube and centrifuge at 5000 rpm for 15 minutes at 4 °C, and collect the supernatant.

[0071] 3. Post-treatment and drying

[0072] 3.1 Filter the supernatant through a 0.45-μm microporous membrane to remove suspended impurities.

[0073] 3.2 Concentrate the filtrate in a rotary evaporator (vacuum degree -0.08 MPa, water bath temperature 60 °C) to 1 / 5 of the original volume (about 400 mL).

[0074] 3.3 Slowly add 3 volumes (1200 mL) of 95% ethanol to the concentrated solution and let it stand at 4 °C for 12 hours to precipitate the polysaccharide.

[0075] 3.4 Centrifuge to collect the precipitate (4000 rpm, 10 minutes), redissolve it with 50 mL of deionized water, and then freeze-dry it (-50 °C, 24 hours) to obtain a white powdery peach gum extract T1 with a yield of 18.5%.

[0076] Preparation of peach gum extract by enzymatic hydrolysis (T2)

[0077] 1. Raw material pretreatment

[0078] 1.1 Take 500 g of naturally dried peach gum raw material (water content ≤ 8%), and use a high-speed grinder (model XX-200) to grind it until the particle size passes through a 100-mesh standard sieve (pore size 150 μm).

[0079] 2. Enzymatic hydrolysis process

[0080] 2.1 Weigh 100 g of peach gum powder, add 1.5 L of deionized water according to the solid-liquid ratio of 1:15 (w / v), and mix evenly by magnetic stirring.

[0081] 2.2 Adjust the pH of the solution to 5.5 with 0.1 M HCl, and add cellulase (enzyme activity 10,000 U / g, addition amount 1% w / w, i.e., 1.5 g).

[0082] 2.3 Carry out enzymatic hydrolysis in a 50 °C constant temperature water bath with shaking (150 rpm) for 3 hours.

[0083] 2.4 After the enzymatic hydrolysis is completed, heat it at 95 °C for 10 minutes to inactivate the enzyme.

[0084] 3. Post-treatment and drying

[0085] 3.1 Coarsely filter the enzyme-inactivated solution through four layers of gauze, and then finely filter it with a 0.45 μm filter membrane.

[0086] 3.2 Concentrate the filtrate under reduced pressure to 300 mL, add four volumes of absolute ethanol (1200 mL), and let it stand at 4 °C for 12 hours.

[0087] 3.3 Centrifuge to collect the precipitate (5000 rpm, 15 minutes), redissolve it and then freeze-dry it to obtain a light yellow powder T2 with a yield of 22.3%.

[0088] Preparation of peach gum extract by ultrasonic-assisted extraction method (T3)

[0089] 1. Raw material pretreatment

[0090] 1.1 Take 500 g of naturally dried peach gum raw material (water content ≤ 8%), and use a high-speed grinder (model XX-200) to grind it until the particle size passes through a 100-mesh standard sieve (pore size 150 μm).

[0091] 2. Ultrasonic extraction process

[0092] 2.1 Weigh 100 g of peach gum powder, add 1 L of deionized water according to the solid-liquid ratio of 1:10 (w / v), and mix evenly.

[0093] 2.2 Place the mixed solution in an ultrasonic extractor (model XX - 3000), and set the parameters as follows:

[0094] Power: 300 W

[0095] Frequency: 40 kHz

[0096] Temperature: 60 °C (water bath temperature control)

[0097] Time: 30 minutes (pulse mode: working for 5 seconds, intermittent for 2 seconds)

[0098] 3. Post-treatment and drying

[0099] 3.1 Centrifuge the ultrasonic solution (5000 rpm, 15 minutes), and filter and concentrate the supernatant to 300 mL.

[0100] 3.2 Add 3 times the volume of 95% ethanol for precipitation, and obtain a light brown powder T3 after freeze-drying, with a yield of 25.7%.

[0101] Preparation of peach gum extract (T4) by microwave-assisted extraction method

[0102] 1. Raw material pretreatment

[0103] 1.1 Take 500 g of naturally dried peach gum raw material (water content ≤ 8%), and use a high-speed crusher (model XX - 200) to crush it to a particle size passing through a 100-mesh standard sieve (aperture 150 μm).

[0104] 2. Microwave extraction process

[0105] 2.1 Weigh 100 g of peach gum powder, and add 1.5 L of deionized water according to the solid-liquid ratio of 1:15 (w / v).

[0106] 2.2 Transfer the mixed solution to a microwave reactor (power 500 W), and set the parameters as follows:

[0107] Temperature: 70 °C

[0108] Time: 15 minutes

[0109] Pressure: atmospheric pressure

[0110] 3. Post-treatment and drying

[0111] 3.1 Filter the microwave extraction solution and concentrate it to 250 mL, and add 4 times the volume of absolute ethanol for precipitation.

[0112] 3.2 Centrifuge to collect the precipitate, and obtain an off-white powder T4 after freeze-drying, with a yield of 23.8%.

[0113] Preparation of Peach Gum Extract (T5) by Supercritical CO2 Extraction Method

[0114] 1. Raw Material Pretreatment

[0115] 1.1 Take 500 g of naturally dried peach gum raw material (water content ≤ 8%) and crush it to a particle size passing through a 100-mesh standard sieve (pore size 150 μm) using a high-speed pulverizer (model XX-200).

[0116] 2. Supercritical CO2 Extraction Process

[0117] 2.1 Weigh 100 g of peach gum powder and add 1 L of deionized water according to a solid-liquid ratio of 1:10 (w / v).

[0118] 2.2 Transfer the mixed solution to a supercritical CO2 extraction device. Set the extraction temperature at 40 °C, the pressure at 25 MPa, and the extraction time at 2 hours. Filter the extract through a filter cloth and collect the filtrate.

[0119] 3. Post-treatment and Drying

[0120] The filtrate is concentrated under reduced pressure to 1 / 5 of its original volume at 50 °C. Add 3 volumes of 95% ethanol to the concentrated solution and let it stand for 12 hours to precipitate polysaccharides. Centrifuge at 4000 rpm for 10 minutes to collect the precipitate. Dissolve the precipitate in a small amount of distilled water and then freeze-dry to obtain peach gum extract T5.

[0121] Example 2: Repair of Heavy Metal-Damaged Cells by Peach Gum Polysaccharide

[0122] Heavy Metal Damage Model (Ni 2 +)

[0123] Model Construction: Treat HFF-1 cells with 6 mM NiCl2 for 12 hours, and the cell survival rate drops to 70.70 ± 9.72%.

[0124] The peach gum polysaccharides (200 μg / mL) of T1 - T4 prepared in Example 1 were all used to repair heavy metal-damaged cells. The results are shown in Table 1. It can be seen from Table 1 that the peach gum polysaccharides extracted by all methods of the present invention have a significant repair effect on heavy metal-damaged cells, significantly improving the survival rate of damaged cells. Among them, the extracts of T3 and T5 have the best effect on improving the cell survival rate.

[0125] Table 1

[0126] Extract Survival rate (%) Significance (vs model group) T1 91.67±2.45 p<0.001 T2 94.89±2.34 p<0.001 T3 97.50±2.34 p<0.001 T4 96.78±2.01 p<0.001 T5 98.12±1.87 p<0.001

[0127] Dose Effect: The peach gum extract shows dose-dependent protection (R 2 > 0.95) in the concentration range of 10 - 200 μg / mL, as shown in Table 2.

[0128] Table 2

[0129] Concentration of peach gum polysaccharide T3 extract (μg / mL) Survival rate (%) 10 84.98±3.01 20 92.49±0.26 50 94.56±2.01 100 96.91±3.60 200 97.50±2.34

[0130] Example 3. Specificity of peach gum polysaccharide in repairing heavy metal damage

[0131] To further verify the specificity of peach gum polysaccharide in repairing heavy metal damage, the inventors used niacinamide and epidermal growth factor (EGF), which theoretically have the same functions as peach gum polysaccharide, for research.

[0132] First, the inventors verified the broad-spectrum verification of the multi-damage model, that is, they used peach gum polysaccharide (T3 extract), EGF, and niacinamide to verify the repair of H2O2 oxidative damage and UVB photo-damage respectively. The results are shown in Table 3. As can be seen from Table 3, the repair effects of peach gum, EGF, and niacinamide on H2O2 oxidative damage and UVB photo-damage are similar, and there are no significant differences.

[0133] Table 3

[0134]

[0135] Secondly, the inventors verified the repair effects of peach gum polysaccharide (T3 extract), EGF, and niacinamide on the damage caused by heavy metals respectively. The results are shown in Table 4. As can be seen from Table 4, EGF and niacinamide did not show obvious repair effects on heavy metal damage. However, at the same time, peach gum polysaccharide showed a significant repair effect on heavy metal damage.

[0136] Finally, the inventors also verified their effects on promoting cell proliferation and surprisingly found that niacinamide and EGF have the effect of promoting the proliferation of normal cells, but they still cannot repair the damage caused by heavy metals. On the contrary, peach gum polysaccharide has no promoting effect on normal cells, but it can repair the damage caused by heavy metals. This further verifies that peach gum polysaccharide repairs heavy metal damage through certain mechanisms that are not generally recognized in the art, and more clearly demonstrates the specificity of peach gum polysaccharide in repairing heavy metal damage.

[0137] Table 4

[0138]

Claims

1. Use of peach gum polysaccharide in preparing products for preventing and / or repairing heavy metal damage to individual skin.

2. The use according to claim 1, characterized in that The final concentration of the peach gum polysaccharide in the product is 10-400 μg / mL, or 10-400 μg / g.

3. The use according to claim 2, characterized in that: The final concentration of the peach gum polysaccharide in the product is 100-300 μg / mL, or 100-300 μg / g.

4. The use according to claim 3, characterized in that The peach gum polysaccharide is extracted by water extraction, enzymatic hydrolysis, ultrasound-assisted method, microwave-assisted method, or supercritical CO2 method.

5. The use according to claim 4, characterized in that The peach gum polysaccharide is extracted by an ultrasound-assisted method or a supercritical CO2 method.

6. The use according to claim 5, characterized in that The ultrasound-assisted method comprises the following steps: crushing peach gum to obtain crushed peach gum; mixing the crushed peach gum with water; extracting the mixture using an ultrasonic extractor to obtain an extract; centrifuging the extract to collect a supernatant; and processing the supernatant to obtain peach gum polysaccharide; or The supercritical CO2 method comprises the following steps: The peach gum is crushed to obtain crushed peach gum; the crushed peach gum is mixed with water; after mixing, a supercritical CO2 extraction device is used to extract to obtain an extract; the extract is filtered to collect the filtrate; and the filtrate is processed to obtain peach gum polysaccharide.

7. The use according to any one of claims 1 to 6, characterized in that The individual is a mammal.

8. The use according to any one of claims 1 to 6, characterized in that The product is a skin care product, a cosmetic, or a pharmaceutical product.

9. The use according to claim 8, characterized in that The product includes one or more of an emollient, a filler, a colorant, a synthetic wax, a humectant, a preservative, a binder, a thickener, or an emulsifier.

10. The use according to claim 9, characterized in that The skin care products are cleansers, essences, lotions, emulsions, or creams, or sunscreens; the cosmetics are air cushions, foundations, loose powders, pressed powders, primers, primers, isolaters, lipsticks, blushers, contouring, or eye shadows.

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