Application of circular RNAcircPOMT1 in diagnosis and / or treatment of pancreatic cancer
CN120193086APending Publication Date: 2025-06-24NO 2 PEOPLES HOSPITAL HUAIAN CITY
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Patent Information
- Application Number
- CN202510671869.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-05-23
- Publication Date
- 2025-06-24
AI Technical Summary
Technical Problem
The prior art lacks understanding of the role and mechanism of circular RNA in pancreatic cancer, making it difficult to effectively diagnose and treat pancreatic cancer.
Method used
Detection and therapeutic agents for the diagnosis of pancreatic cancer, including biochips, kits and drug preparations, are developed by using circular RNAcircPOMT1 and miR-767-5p as biomarkers.
Benefits of technology
circPOMT1 is significantly low in pancreatic cancer tissues, and its expression level is related to the overall survival of patients. By targeting miR-767-5p, circPOMT1 can inhibit the proliferation, migration and invasion of PDAC cells, providing new ideas for the early diagnosis and development of targeted treatments for pancreatic cancer.
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Figure CN120193086A_ABST
Abstract
The invention discloses application of circular RNAcircPOMT1 in diagnosis and / or treatment of pancreatic cancer, and belongs to the technical field of biological medicine. According to the application disclosed by the invention, qPCR verification and clinical prognosis analysis are carried out on pancreatic cancer tissues, so that the circPOMT1 (hsacirc0001897) is found to be remarkably low in expression in the pancreatic cancer tissues, and the expression level of the circPOMT1 is positively correlated with the total lifetime of a patient. In addition, in-vivo and in-vitro experiments prove that circPOMT1 inhibits proliferation, migration and invasion of PDAC cells and inhibits tumor generation and metastasis of the PDAC cells. And meanwhile, the circPOMT1 is used for inhibiting the PDAC process by targeting miR-767-5p (miR-767-5p). A novel molecular marker is provided for early diagnosis of pancreatic cancer, and a theoretical basis is laid for developing a targeted therapy strategy based on circRNA and miR-767-5p.
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