Anti-allergic and anti-reflux special medical infant amino acid formula food composition as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of food, and particularly relates to an anti-allergic and anti-reflux special medical infant amino acid formula food composition as well as a preparation method and application thereof. The special medical infant amino acid formula food composition comprises 22-35 g of maltodextrin, 10-20 g of pregelatinized starch, 10-15 g of compound vegetable oil, 13-17 g of starch sodium octenylsuccinate, 7-11 g of medium chain triglyceride, 8-10 g of compound amino acid and the balance of compound nutrients in terms of 100 g, the compound amino acid is prepared from aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine according to the mass ratio of (7 to 9) to (10 to 11) to (7 to 8) to (17 to 18) to (5.5 to 6) to (5.5 to 6) to (5 to 5.5) to (4.5 to 5). The special medical infant amino acid formula food composition provided by the invention has proper viscosity, so that the reflux problem can be avoided; the beverage is good in taste, easy to brew and low in osmotic pressure.

Description

Technical Field

[0001] The present invention belongs to the technical field of food, and particularly relates to a special medical infant amino acid formula food composition for anti-allergy and anti-reflux, a preparation method and an application thereof. Background Art

[0002] Cow's milk protein allergy and gastroesophageal reflux are common in infants and young children. There are many common symptoms between the two, such as vomiting, infantile colic and dysplasia.

[0003] Cow's milk protein allergy is an abnormal immune reaction caused by cow's milk protein. Therefore, a protein-free food formula is of great significance for preventing cow's milk protein allergy. At present, compound amino acid formula foods have received extensive attention because they can not only provide essential nutrients for the human body but also avoid cow's milk protein allergy.

[0004] For example, Chinese Patent with publication number CN109497533A discloses a lactose-free amino acid infant formula suitable for infants with food protein allergy. This technical solution studies the production of lactose-free amino acid infant formula by dry process. First, plant fat powder is produced by microencapsulation process, and then plant fat powder, amino acid compound ingredients, other auxiliary materials and bioactive substances are dry-mixed into an amino acid formula powder suitable for treating food protein allergy in infants aged 0-12 months. The protein equivalent in the formula is provided by amino acid compound ingredients. This product is suitable for infants with food protein allergy and lactose intolerance to avoid food protein and lactose.

[0005] Li Liushao published "Analysis of the Efficacy of Free Amino Acid Formula Powder in the Treatment of Infants with Cow's Milk Protein Allergy" in a medical journal. In this study, free amino acid formula powder (Neocate Special Formula Nutrition Powder: vegetable fat powder (glucose syrup powder, sunflower oil, medium-chain triglycerides, rapeseed oil, citric acid fatty acid glyceride, arachidonic acid oil, docosahexaenoic acid oil, ascorbyl palmitate), L-leucine, L-lysine acetate, L-glutamine, L-proline, L-arginine, L-valine, glycine, L-isoleucine, L-aspartic acid, L-threonine, L-phenylalanine, L-tyrosine, L-serine, L-histidine, L-alanine, L-cystine, L-tryptophan, L-methionine, magnesium L-aspartate, maltodextrin, glucose syrup powder, vitamin A acetate, cholecalciferol, dl-α-tocopheryl acetate, phylloquinone, thiamine hydrochloride, riboflavin, pyridoxine hydrochloride, cyanocobalamin, nicotinamide, folic acid, calcium D-pantothenate, L-ascorbic acid, D-biotin, sodium chloride, potassium citrate, dipotassium hydrogen phosphate, copper sulfate, magnesium chloride, ferrous sulfate, zinc sulfate, manganese sulfate, calcium carbonate, calcium citrate, calcium hydrogen phosphate, tricalcium phosphate, calcium glycerophosphate, potassium iodide, sodium selenite, chromium chloride, sodium molybdate, choline bitartrate, inositol, taurine, L-carnitine, 5'-cytidine monophosphate, 5'-adenosine monophosphate, disodium 5'-inosinate, disodium 5'-guanylate, disodium 5'-uridylate) was used to treat allergic infants, and the improvement of symptoms, blood indicators, and nutritional status before and after treatment was compared. The results showed that free amino acid formula powder can improve symptoms such as diarrhea and vomiting in infants with cow's milk protein allergy, improve blood indicators, and improve the situation of malnutrition.

[0006] However, the above technical solutions only focus on avoiding cow's milk protein allergy problems, but do not pay attention to the fact that many amino acids (such as leucine, isoleucine, valine, etc.) themselves have a strong odor, and these amino acids will cause the overall taste of the milk powder to be bitter or sour after dissolution, as well as the problem that the introduction of a large number of small molecule amino acids will cause a significant increase in the osmotic pressure of the milk powder.

[0007] The solutions for gastroesophageal reflux usually involve adding highly branched pregelatinized starch or thickeners (xanthan gum and locust bean gum) to the product. However, xanthan gum and locust bean gum, as indigestible polysaccharides, will lead to a reduction in calorie and nutrient intake after ingestion, and they can be fermented by colonic bacteria, and some infants may experience reactions such as abdominal pain and diarrhea. Although pregelatinized starch can be digested in the body and converted into glucose, which is finally absorbed in the form of glucose, thus avoiding the problems caused by xanthan gum and locust bean gum, the mixing of pregelatinized starch with formula milk will produce randomly dispersed insoluble particles and lumps, resulting in problems such as uneven viscosity and wall sticking after reconstitution. Summary of the Invention

[0008] In view of the above problems, the present invention provides a special medical infant amino acid formula food composition with anti-allergy and anti-reflux functions, a preparation method and an application thereof.

[0009] To achieve the above object, the technical solution adopted by the present invention is as follows:

[0010] In the first aspect of the present invention, there is provided a special medical infant amino acid formula food composition with anti-allergy and anti-reflux functions. Calculated by 100 g, it includes 22 - 35 g of maltodextrin, 10 - 20 g of pregelatinized starch, 10 - 15 g of compound vegetable oil, 13 - 17 g of octenyl succinic anhydride starch sodium, 7 - 11 g of medium-chain triglycerides, 8 - 10 g of compound amino acids, and the remaining amount is made up to 100 g with compound nutrients;

[0011] The compound amino acids include aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine in a mass ratio of 7 - 9:10 - 11:7 - 8:17 - 18:5.5 - 6:5.5 - 6:5 - 5.5:4.5 - 5.

[0012] Further preferably, the compound amino acids include aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine in a mass ratio of 8:10.8:7.3:17.4:5.9:5.8:5.2:4.9.

[0013] Further preferably, calculated by 100 g, the special medical infant amino acid formula food composition includes 22 - 30 g of maltodextrin, 12 - 20 g of pregelatinized starch, 13 g of compound vegetable oil, 15 g of octenyl succinic anhydride starch sodium, 9 g of medium-chain triglycerides, 11.99 g of compound amino acids, and the remaining amount is made up to 100 g with compound nutrients.

[0014] Even more preferably, calculated by 100 g, the special medical infant amino acid formula food composition includes 30 g of maltodextrin, 12 g of pregelatinized starch, 13 g of compound vegetable oil, 15 g of octenyl succinic anhydride starch sodium, 9 g of medium-chain triglycerides, 11.99 g of compound amino acids, and the remaining amount is made up to 100 g with compound nutrients.

[0015] In some preferred embodiments, the compound amino acids further include one or more combinations of proline, tyrosine, serine, alanine, arginine, histidine, cystine, glycine, tryptophan and methionine.

[0016] Preferably, the composition of the compound amino acids is as follows:

[0017]

[0018]

[0019] In some preferred embodiments, the compound nutrient includes glutamine, choline chloride, 2'-fucosyllactose, solid corn syrup, arachidonic acid oil, docosahexaenoic acid oil, compound vitamins and compound minerals.

[0020] Preferably, the mass ratio of choline chloride, 2'-fucosyllactose, solid corn syrup, arachidonic acid oil, docosahexaenoic acid oil, compound vitamins and compound minerals is 1-2: 0.5-1.5: 0.2-0.6: 0.3-0.5: 0.3-0.4: 0.4-0.5: 4-5.

[0021] More preferably, the mass ratio of choline chloride, 2'-fucosyllactose, solid corn syrup, arachidonic acid oil, docosahexaenoic acid oil, compound vitamins and compound minerals is 1.5: 1: 0.5: 0.43: 0.33: 0.47: 4.78.

[0022] Preferably, the compound vitamins include sodium ascorbate, vitamin E, vitamin B6, mixed tocopherol concentrate, vitamin B2, vitamin A, niacin, pantothenic acid, vitamin D, biotin, vitamin B 12 , folic acid, vitamin K1 and vitamin B1.

[0023] More preferably, the composition of the compound vitamins is as follows:

[0024]

[0025]

[0026] Preferably, the compound minerals include calcium hydrogen phosphate, potassium chloride, sodium citrate, potassium citrate, magnesium sulfate, calcium sulfate, zinc sulfate, ferrous sulfate, potassium iodate, copper sulfate, tricalcium phosphate, sodium selenite and manganese sulfate.

[0027] More preferably, the composition of the compound minerals is as follows:

[0028]

[0029]

[0030] Most preferably, the composition of the special medical infant amino acid formula food composition per 100 g is as follows:

[0031]

[0032] Among them, the composition of the compound amino acids is as follows:

[0033]

[0034]

[0035] The compound nutrient composition is as follows:

[0036]

[0037] The compound vitamin composition is as follows:

[0038]

[0039]

[0040] The compound mineral composition is as follows:

[0041]

[0042] The second aspect of the present invention provides a preparation method of the above-mentioned special medical infant amino acid formula food composition, including the following steps: Mix evenly according to the formula.

[0043] The third aspect of the present invention provides the application of the above-mentioned special medical infant amino acid formula food composition in the preparation of products for anti-cow milk protein allergy and anti-reflux.

[0044] Compared with the prior art, the present invention has the following beneficial effects:

[0045] 1. By controlling the contents of maltodextrin and pregelatinized starch in the special medical infant amino acid formula food composition, the present invention obtains an appropriate viscosity to avoid the problem of reflux.

[0046] 2. By controlling the compound amino acids including aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine with a mass ratio of 7-9:10-11:7-8:17-18:5.5-6:5.5-6:5-5.5:4.5-5, the present invention avoids the problem of uncomfortable taste.

[0047] 3. By controlling the contents of each component in the special medical infant amino acid formula food composition, the present invention reduces the osmotic pressure and improves the food safety.

[0048] 4. The special medical infant amino acid formula food composition provided by the present invention is completely free of protein allergens and lactose, and by adding compound nutrients, especially the addition of 2'-fucosyllactose can promote the establishment of the intestinal immune barrier. Description of the Drawings

[0049] Figure 1 The reconstitution result of the special medical infant amino acid formula food composition for Example 1;

[0050] Figure 2 Result of the reconstitution of the special medical infant amino acid formula food composition of Example 2;

[0051] Figure 3 Result of the reconstitution of the special medical infant amino acid formula food composition of Example 3. Detailed Description of the Invention

[0052] The various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, characteristics, and embodiments of the present invention.

[0053] It should be understood that the terms used in the present invention are only for describing particular embodiments and are not intended to limit the present invention. Additionally, for the numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Each intermediate value within any stated value or stated range, as well as each smaller range between any other stated value or intermediate value within the stated range, is also included in the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0054] Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present invention pertains. Although the present invention only describes preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials related to the documents. In case of conflict with any incorporated document, the content of this specification shall prevail.

[0055] Without departing from the scope or spirit of the present invention, various improvements and changes can be made to the specific embodiments of the present invention specification, which are obvious to those skilled in the art. Other embodiments obtained from the specification of the present invention are obvious to those skilled in the art. The specification and examples of the present invention are merely exemplary.

[0056] Regarding the use of "comprising", "including", "having", "containing", etc. in this article, they are all open-ended terms, meaning including but not limited to.

[0057] The sources of the raw materials used in the following examples and comparative examples are as follows:

[0058] The compound vegetable oil was purchased from Yihai Kerry, model: Shaniya edible vegetable oil blend ARSMO - 02YQ.

[0059] The mixed tocopherol concentrate was purchased from Xi'an Pureze Biotech Co., Ltd.

[0060] The raw materials not specifically indicated are all commercially available products, and their sources are not specifically limited.

[0061] Example

[0062] The special medical infant amino acid formula food composition with anti-allergic and anti-reflux properties, calculated by 100 g, has the following composition:

[0063]

[0064] Among them, the composite amino acids in Examples 1-3 have the same composition, as follows:

[0065]

[0066]

[0067] The composite nutrients in Examples 1-3 have the same composition, as follows:

[0068]

[0069]

[0070] The compound vitamins in Examples 1-3 have the same composition, as follows:

[0071] The compound minerals in Examples 1-3 have the same composition, as follows:

[0072]

[0073]

[0074] The preparation method of the above special medical infant amino acid formula food composition with anti-allergic and anti-reflux properties is: mix evenly according to the formula of Examples 1-3.

[0075] Comparative Example 1

[0076] The difference from Example 1 is only that the composite amino acid composition is different, and the rest are the same. The composite amino acid composition is as follows:

[0077]

[0078]

[0079] Comparative Example 2

[0080] The difference from Example 1 is only that the composite amino acid composition is different, and the rest are the same. The composite amino acid composition is as follows:

[0081]

[0082]

[0083] Comparative Example 3

[0084] The difference from Example 1 is only that the composition content of the special medical infant amino acid formula food composition is different, and the rest are the same; calculated by 100 g, the composition is as follows:

[0085]

[0086] Comparative Example 4

[0087] The difference from Example 1 is only that the composition content of the special medical infant amino acid formula food composition is different, and the rest are the same; calculated by 100 g, the composition is as follows:

[0088]

[0089] Comparative Example 5

[0090] The difference from Example 1 is that the composition components and contents of the special medical infant amino acid formula food composition are different, and the rest are the same; calculated by 100 g, the composition is as follows:

[0091]

[0092] Performance test:

[0093] 1. Sensory evaluation:

[0094] Select 8 evaluators with professional knowledge in milk powder and good sensory analysis ability, and without diseases such as color blindness, rhinitis, dental caries, and stomatitis. Each person evaluates the special medical infant amino acid formula food composition powder of Examples 1-3 and Comparative Examples 1-5 respectively. Before the evaluation, they should not be overfull or hungry, should not eat foods with strong flavors or irritating foods, and should not smoke or drink alcohol, and avoid using cosmetics.

[0095] Comprehensive sensory evaluation is carried out from two aspects of the powder quality and the prepared liquid of the special medical infant amino acid formula food composition. The preparation method of the prepared liquid is as follows: First, take a cup of warm water at about 40 °C, about 90 mL, take 13.5 g of the prepared special medical infant amino acid formula food composition (about 3 spoons) and add it to the warm water, and stir for 10 min while adding.

[0096] The results are as follows:

[0097] The special medical infant amino acid formula food composition powder of Example 1 has a slightly pungent smell, and the prepared liquid has no abnormal smell;

[0098] The powder of the special medical infant amino acid formula food composition of Example 2 has a slightly pungent smell, and the reconstituted liquid has no abnormal smell;

[0099] The powder of the special medical infant amino acid formula food composition of Example 3 has a slightly pungent smell, and the reconstituted liquid has no abnormal smell;

[0100] The powder of the special medical infant amino acid formula food composition of Comparative Example 1 has a pungent smell, and the reconstituted liquid tastes sour and bitter;

[0101] The powder of the special medical infant amino acid formula food composition of Comparative Example 2 has a faint traditional Chinese medicine smell and is sour, and the reconstituted liquid tastes sour;

[0102] The powder of the special medical infant amino acid formula food composition of Comparative Example 3 has a slightly pungent smell, and the reconstituted liquid has no abnormal smell;

[0103] The powder of the special medical infant amino acid formula food composition of Comparative Example 4 has a slightly pungent smell, and the reconstituted liquid has no abnormal smell;

[0104] The powder of the special medical infant amino acid formula food composition of Comparative Example 5 has a pungent smell, and the reconstituted liquid has a strong taste.

[0105] The results show that: the special medical infant amino acid formula food compositions of Examples 1-3 have good comprehensive sensory properties; while in Comparative Examples 1-2, due to the change of the amino acid formula, and in Comparative Example 5, due to the change of the formula of the special medical infant amino acid formula food composition, the comprehensive sensory properties become worse.

[0106] 2. Osmotic pressure: The special medical infant amino acid formula food composition and the commercially available products were measured according to the osmotic pressure of special foods in BJS 202102, and the results are shown in Table 1.

[0107] Commercially available products include Neocate Syneo Infant Amino Acid Formula for Special Medical Purpose (SHS International Ltd), Similac Alimentum Infant Amino Acid Formula for Special Medical Purpose (Nestle Nederland B.V.), BlisMil Special Medical Purpose Infant Amino Acid Formula (Odyssey Laboratories Limited), Combiotic Hypoallergenic Infant Formula with Amino Acids (Vitaflo Comidamed GmbH)

[0108] Table 1

[0109] Example Osmotic pressure (mOsm / kg) Example 1 286 Example 2 295 Example 3 297 Comparative Example 1 289 Comparative Example 2 290 Comparative Example 3 302 Comparative Example 4 297 Comparative Example 5 342 Neocate 350 Similac 332 Blemil 330 Complan 319

[0110] Hyperosmolarity (≥300 mOsm / L) may lead to hypernatremia and hyperazotemia, induce necrotizing enterocolitis, and have an adverse impact on the kidneys. Some studies have pointed out that the average osmotic pressure of amino acid-based formula milk powder reaches 328 mOsm / kg, meeting the hyperosmolarity standard. Therefore, the increase in osmotic pressure should be minimized as much as possible. As can be seen from Table 1, the osmotic pressures of commercially available products are all greater than 300 mOsm / kg, while the osmotic pressures of the special medical infant amino acid formula food compositions in Examples 1-3 of the present invention are all less than 300 mOsm / kg. In particular, the special medical infant amino acid formula food composition of Example 1 has a lower osmotic pressure. Therefore, the formula of the present invention is safer. In Comparative Examples 3 and 5, due to the change in the formula composition, the osmotic pressure is greater than 300 mOsm / kg.

[0111] 3. Viscosity: The special medical infant amino acid formula food composition is carried out according to the method in 5.4.1.2 of GB / T 22427.7-2023 for starch viscosity determination. The preparation method is as follows: 13.5 g of the special medical infant amino acid formula food composition is added to 90 mL of water, and the water temperature is maintained at 45 °C. The results are shown in Table 2.

[0112] Table 2

[0113]

[0114]

[0115] It is considered in the art that a viscosity value between 30-300 cp has a good anti-reflux function. As can be seen from Table 2, the special medical infant amino acid formula food compositions of Examples 1-3 and Comparative Examples 1-2 all meet the requirements; while in Comparative Examples 3-5, due to the change in the formula of the special medical infant amino acid formula food composition, they do not have the anti-reflux function.

[0116] 4. Preparation state: First, take a cup of warm water at about 40 °C, about 90 mL. Take 13.5 g of the special medical infant amino acid formula food compositions of Examples 1-3 (about 3 spoons) and add them to the warm water, stirring while adding. Observe the state at 10 minutes after preparation. The preparation results of the special medical infant amino acid formula food composition of Example 1 are as Figure 1 shown; the preparation results of the special medical infant amino acid formula food composition of Example 2 are as Figure 2 shown; the preparation results of the special medical infant amino acid formula food composition of Example 3 are as Figure 3 shown.

[0117] An increase in viscosity usually causes an extension of the reconstitution time. At 10 minutes of reconstitution, the reconstitution effect of the special medical infant amino acid formula food composition of Example 1 is the best, without caking phenomenon, and the solution state is relatively delicate; the reconstitution effects of the special medical infant amino acid formula food compositions of Example 2 and Example 3 are slightly worse, with caking phenomena to varying degrees, and the solutions are relatively rough.

[0118] The above is a further description of the present invention in combination with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

Claims

1. An anti-allergic and anti-reflux special medical infant amino acid formula food composition, characterized in that: Based on 100g, it includes 22-35g of maltodextrin, 10-20g of pregelatinized starch, 10-15g of compound vegetable oil, 13-17g of sodium starch octenylsuccinate, 7-11g of medium-chain triglycerides, 8-10g of compound amino acids, and the rest of compound nutrients is supplemented to 100g; The composite amino acids include aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine in a mass ratio of 7-9:10-11:7-8:17-18:5.5-6:5.5-6:5-5.5:4.5-5.

2. The amino acid formula food composition for special medical infants according to claim 1, characterized in that: The composite amino acids include aspartic acid, leucine, lysine, glutamine, isoleucine, valine, phenylalanine and threonine in a mass ratio of 8:10.8:7.3:17.4:5.9:5.8:5.2:4.

9.

3. The amino acid formula food composition for special medical purposes for infants according to claim 2, characterized in that: The amino acid formula food composition for special medical infants, calculated on a 100 g basis, comprises 22-30 g maltodextrin, 12-20 g pregelatinized starch, 13 g compound vegetable oil, 15 g sodium starch octenylsuccinate, 9 g medium-chain triglycerides, 11.99 g compound amino acids, and the remainder of compound nutrients is supplemented to 100 g.

4. The amino acid formula food composition for special medical purposes for infants according to claim 3, characterized in that: The amino acid formula food composition for special medical infants, calculated on a 100 g basis, includes 30 g maltodextrin, 12 g pregelatinized starch, 13 g compound vegetable oil, 15 g sodium starch octenylsuccinate, 9 g medium-chain triglycerides, 11.99 g compound amino acids, and the remainder of compound nutrients is supplemented to 100 g.

5. The amino acid formula food composition for special medical purposes for infants according to claim 4, characterized in that: The complex amino acids further include one or more combinations of proline, tyrosine, serine, alanine, arginine, histidine, cystine, glycine, tryptophan and methionine.

6. The amino acid formula food composition for special medical infants according to any one of claims 1 to 5, characterized in that: The composite amino acid is composed as follows:

7. The amino acid formula food composition for special medical purposes for infants according to claim 6, characterized in that: The compound nutrients include choline chloride, 2'-fucosyllactose, solid corn syrup, arachidonic acid oil, docosahexaenoic acid oil, compound vitamins and compound minerals.

8. The amino acid formula food composition for special medical purposes for infants according to claim 7, characterized in that: The compound vitamins include sodium ascorbate, vitamin E, vitamin B6, mixed tocopherol concentrate, vitamin B2, vitamin A, niacin, pantothenic acid, vitamin D, biotin, vitamin B 12 , folic acid, vitamin K1 and vitamin B1.

9. The method for preparing the amino acid formula food composition for special medical infants according to any one of claims 1 to 8, characterized in that: The method comprises the following steps: mixing evenly according to the formula.

10. Use of the amino acid formula food composition for special medical infants according to any one of claims 1 to 8 or the amino acid formula food composition for special medical infants prepared by the preparation method according to claim 9 in the preparation of anti-milk protein allergy and anti-reflux products.

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