Traditional Chinese medicine preparation for treating ARDS and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine preparation for treating ARDS and a preparation method thereof. The traditional Chinese medicine preparation for treating ARDS is prepared from the following components in parts by weight: 20 to 40 parts of cortex mori radicis, 15 to 35 parts of rhizoma pinelliae, 15 to 20 parts of semen lepidii, 5 to 10 parts of perillaseed, 5 to 10 parts of almond, 5 to 10 parts of fritillary bulb, 15 to 25 parts of radix scutellariae, 8 to 10 parts of radix astragali seu hedysari, 8 to 10 parts of radix codonopsis, 3 to 5 parts of cortex magnoliae officinalis, 5 to 10 parts of pericarpium citri reticulatae, 5 to 10 parts of poria cocos, 1 to 3 parts of rhizoma zingiberis recens, 10 to 12 parts of fructus ziziphi jujubae and 10 to 12 parts of liquorice root. Through screening and compatibility of traditional Chinese medicinal materials, the synergistic effect of multiple effects of removing phlegm, clearing heat, relieving cough and asthma and the like is achieved, meanwhile, in the preparation process, according to different medicine properties and shapes of the medicinal materials, the medicinal materials are ground in different cavities, and the situation that the medicinal materials sink to the bottom in the decoction process is reduced in an automatic decoction mode.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine preparation for treating ARDS and a preparation method thereof. Background Art

[0002] Acute respiratory distress syndrome (ARDS) is a syndrome that occurs during the course of severe infections, traumas, burns, shocks and other diseases. Due to inflammatory reactions, it causes changes in the permeability of alveoli, capillaries, epithelial cells and alveolar epithelial cells, with diffuse alveolar exudation as the main feature and refractory hypoxemia and respiratory distress as the main clinical manifestations. The fatality rate of ARDS is as high as 40%, which is a clinically severe syndrome. At present, the treatment of ARDS mainly relies on intensive care and mechanical ventilation, but there are still great uncertainties in the treatment effect and the prognosis of patients.

[0003] From the perspective of traditional Chinese medicine, the treatment of ARDS can be achieved through the traditional Chinese medicine effects such as eliminating phlegm and clearing heat, relieving cough and asthma. Traditional Chinese medicine preparations have unique advantages and potentials, and can improve pulmonary circulation and correct respiratory failure through various action mechanisms. Although traditional Chinese medicine shows unique advantages and potentials in the treatment of ARDS, there are still some defects in the existing traditional Chinese medicine preparations for treating ARDS and their preparation methods. First of all, some traditional Chinese medicine preparations do not fully consider the interaction and compatibility taboos between Chinese herbal medicines during the preparation process, resulting in unstable curative effects of the preparations and even possible adverse reactions. In addition, some traditional Chinese medicine preparations contain a variety of Chinese herbal medicines, and the raw materials sink unevenly during the decocting process and are prone to accumulate at the bottom of the decocting tank, increasing the preparation cost while also making the medicinal properties of the Chinese herbal medicines unable to be effectively utilized during decoction. Therefore, in view of the defects of the existing traditional Chinese medicine preparations for treating ARDS and their preparation methods in terms of medication, preparation process and quality control, a traditional Chinese medicine preparation for treating ARDS and a preparation method thereof are proposed. Summary of the Invention

[0004] To solve the above problems, the present invention provides a traditional Chinese medicine preparation for treating ARDS and a preparation method thereof. By screening and compatibly combining Chinese herbal medicines, the synergistic effects of various effects such as eliminating phlegm and clearing heat, relieving cough and asthma are achieved. At the same time, during the preparation process, according to the different medicinal properties and shapes of the herbs, the herbs are ground in separate chambers and the sedimentation of the herbs during decoction is reduced through an automated decocting method.

[0005] To achieve the above object, the technical solution of the present invention is as follows: A traditional Chinese medicine preparation for treating ARDS, comprising the following components in parts by weight: 20-40 parts of mulberry bark, 15-35 parts of pinellia, 15-20 parts of lepidium seed, 5-10 parts of perilla seed, 5-10 parts of apricot kernel, 5-10 parts of fritillaria, 15-25 parts of scutellaria baicalensis, 8-10 parts of astragalus membranaceus, 8-10 parts of codonopsis pilosula, 3-5 parts of magnolia officinalis, 5-10 parts of dried tangerine peel, 5-10 parts of poria cocos, 1-3 parts of ginger, 10-12 parts of jujube and 10-12 parts of liquorice.

[0006] Further, 20 parts of mulberry bark, 15 parts of pinellia, 15 parts of lepidium seed, 5 parts of perilla seed, 5 parts of apricot kernel, 5 parts of fritillaria, 10 parts, 15 parts of scutellaria baicalensis, 8 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 3 parts of magnolia officinalis, 5 parts of dried tangerine peel, 5 parts of poria cocos, 1 part of ginger, 10 parts of jujube and 10 parts of liquorice.

[0007] Further, 30 parts of mulberry bark, 25 parts of pinellia, 18 parts of lepidium seed, 8 parts of perilla seed, 7 parts of apricot kernel, 7 parts of fritillaria, 12 parts, 20 parts of scutellaria baicalensis, 9 parts of astragalus membranaceus, 9 parts of codonopsis pilosula, 4 parts of magnolia officinalis, 8 parts of dried tangerine peel, 7 parts of poria cocos, 2 parts of ginger, 11 parts of jujube and 11 parts of liquorice.

[0008] Further, 40 parts of mulberry bark, 35 parts of pinellia, 10 parts of perilla seed, 10 parts of apricot kernel, 10 parts of fritillaria, 15 parts, 25 parts of scutellaria baicalensis, 10 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 5 parts of magnolia officinalis, 10 parts of dried tangerine peel, 10 parts of poria cocos, 3 parts of ginger, 12 parts of jujube and 12 parts of liquorice.

[0009] A preparation method of a traditional Chinese medicine preparation for treating ARDS, comprising the following steps:

[0010] Step 1, cleaning traditional Chinese medicine: Weigh mulberry bark, pinellia, lepidium seed, perilla seed, apricot kernel, fritillaria, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, magnolia officinalis, dried tangerine peel, poria cocos, ginger, jujube and liquorice according to parts by weight, remove the worms and rotten parts therein, wash with clean water and then rinse with sterile distilled water;

[0011] Step 2, raw material treatment: Place mulberry bark, pinellia, lepidium seed, perilla seed, apricot kernel, fritillaria, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, magnolia officinalis, dried tangerine peel, poria cocos, ginger, jujube and liquorice in a decocting device and crush them respectively to obtain traditional Chinese medicine granules;

[0012] Step 3, preparing decoction: Place the traditional Chinese medicine granules in a decocting device, soak them in water and then decoct, filter to obtain the first decoction liquid and the residue respectively, add water to the residue and decoct again, filter after the second decoction boils to obtain the second filtrate, mix the second filtrate with the first decoction liquid to obtain the decoction liquid, add the decoction liquid into a volumetric flask, vortex and mix, filter with a filter membrane to collect the filtrate, and thus obtain the traditional Chinese medicine preparation for treating ARDS.

[0013] Further, in Step 2, the diameter of the mashed traditional Chinese medicine granules is sieved through a 4-mesh sieve and not through a 10-mesh sieve.

[0014] Further, in Step 3, the soaking time in water is 60 min. When decocting, first bring to a boil over high heat, and then adjust the power to low heat through the decocting device to keep the liquid medicine boiling but the liquid surface without fluctuations for 30 min. The boiling time for the second decoction is 20 min.

[0015] Further, in Step 3, after the decocted liquid is added to the volumetric flask, it is fixed with methanol. After vortex mixing, the pore size of the filter membrane used is 0.45 μm.

[0016] Further, in Steps 2 and 3, the decocting device includes a tank body. A crushing chamber is fixedly connected to the top of the tank body. A crushing assembly for crushing traditional Chinese medicine materials and recovering the crushed traditional Chinese medicine residues is provided in the crushing chamber. A feeding assembly is communicated with the top of the crushing chamber. A decocting assembly for decocting traditional Chinese medicine materials is provided in the tank body. The decocting assembly is signal-connected to a controller. A conveying assembly for conveying the crushed traditional Chinese medicine granules is provided in the decocting assembly. The conveying assemblies are all communicated with the crushing chamber. A stirring assembly for stirring the decoction and preventing the medicinal residues from sinking to the bottom is fixedly connected to the bottom of the conveying assembly.

[0017] Further, a first partition board is provided in the crushing chamber. The first partition board divides the crushing chamber into a crushing layer and a conveying layer from top to bottom. The feeding assembly includes a first straight cylinder fixedly connected to the top of the first partition board. A first conveying cylinder fixedly connected to the top of the first partition board is arranged outside the first straight cylinder. A first conveying channel is arranged between the first straight cylinder and the first conveying cylinder. A plurality of second partition boards are fixedly connected between the first straight cylinder and the first conveying cylinder. The second partition boards divide the first conveying channel into a plurality of feeding channels. Feeding ports communicated with the outside are opened at the tops of the feeding channels. A plurality of electric rotating shafts corresponding to the feeding channels are arranged in the crushing layer. The electric rotating shafts are all signal-connected to the controller. A plurality of blades are fixedly connected to the electric rotating shafts. A plurality of filter meshes and pressure sensors are arranged on the partition board. The filter meshes and the pressure sensors are both located in each feeding channel. A plurality of recovery boxes are arranged on one side of the crushing layer far away from the first straight cylinder. The recovery boxes correspond to the feeding channels one by one. An air pump is arranged in the first straight cylinder. An air outlet channel communicating the inside of the first straight cylinder with the feeding channels is arranged on the first straight cylinder in a ring shape. The air pump and the pressure sensors are both signal-connected to the controller;

[0018] A transparent window is also hinged on the tank body. The decocting assembly includes a decocting tank fixedly connected to the inner bottom wall of the tank body. A transparent tank cover is hinged on the top of the decocting tank. The decocting tank is communicated with a water delivery pipe. One end of the water delivery pipe far away from the decocting tank extends to the outside of the tank body and is communicated with a water tank. A plurality of electric heating wires are arranged in the interlayer of the decocting tank. The electric heating wires are all signal-connected to the controller;

[0019] The conveying assembly includes a second straight cylinder and a second conveying cylinder located outside the second straight cylinder. The tops of the second straight cylinder and the second conveying cylinder both extend into the conveying layer and are fixedly connected to the bottom of the first partition. A second conveying channel is provided between the second straight cylinder and the second conveying cylinder. A number of third partitions are fixedly connected between the second straight cylinder and the second conveying cylinder. The third partitions divide the second conveying channel into a number of feeding channels. The feeding channels correspond to the feeding channels one by one, and a sliding chute is connected between each feeding channel and the feeding channel.

[0020] The bottoms of the second conveying cylinder and the second straight cylinder both extend into the decocting tank. A number of conveying pipes are fixedly connected to the outside of the second conveying cylinder. The conveying pipes correspond to and communicate with the feeding channels. A number of first discharge ports are opened at the ends of the conveying pipes far from the feeding channels. A number of second discharge ports corresponding to the feeding channels are opened at the bottom of the first conveying cylinder.

[0021] The stirring assembly includes a motor box fixedly connected inside the second straight cylinder. A servo motor is fixedly connected to the top inside the motor box. An insulating layer for isolating the motor box from the high temperature of the external liquid medicine is provided on the inner wall of the second straight cylinder. A transmission rod is coaxially and fixedly connected to the output shaft of the servo motor. One end of the transmission rod extends into the decocting tank and is fixedly connected with a number of scrapers. The servo motor is signal-connected to the controller.

[0022] The effects of each component used in the present invention are as follows:

[0023] Mulberry bark: sweet in taste, cold in nature. It belongs to the lung meridian. It has the effects of purging the lung to relieve asthma and promoting diuresis to alleviate edema. It is mainly used for treating asthma due to lung heat, edema with fullness and oliguria, and swelling of the face and skin.

[0024] Pinellia ternata: pungent in taste, warm in nature; toxic. It belongs to the spleen, stomach and lung meridians. It has the effects of drying dampness and resolving phlegm, lowering adverse qi and stopping vomiting, and dissipating binds and nodules. It is mainly used for treating damp phlegm and cold phlegm, cough with profuse phlegm, dizziness due to phlegm retention, wind phlegm dizziness, headache due to phlegm syncope, adverse qi of the stomach, vomiting and nausea, stuffiness and discomfort in the chest, plum pit qi, carbuncle and swelling, scrofula and phlegm nodes, and snake bites.

[0025] Descurainia sophia: pungent and bitter in taste, cold in nature. It belongs to the lung, bladder and large intestine meridians. It has the effects of purging the lung to lower qi, eliminating phlegm and relieving asthma, promoting diuresis to alleviate edema, and purging heat and expelling pathogens. It is mainly used for treating dyspnea and profuse phlegm due to phlegm congestion in the lung, lung abscess, edema, accumulation of fluid in the chest and abdomen, dysuria, and also for treating carbuncle and ulcer, scrofula and tuberculosis.

[0026] Perilla seed: pungent in taste, warm in nature. It belongs to the lung and large intestine meridians. It has the effects of lowering qi and resolving phlegm, relieving cough and asthma, and moistening the intestine and promoting defecation. It is mainly used for treating phlegm congestion and qi reversal, cough and asthma, and constipation due to intestinal dryness.

[0027] Apricot kernel: bitter in taste, slightly warm in nature; slightly toxic. It belongs to the lung and large intestine meridians. It has the effects of lowering qi, relieving cough and asthma, and moistening the intestine and promoting defecation. It is mainly used for treating cough and asthma, fullness in the chest and profuse phlegm, and constipation due to intestinal dryness.

[0028] Fritillaria: Bitter in taste, cold in nature. It acts on the lung and heart meridians. It has the effects of clearing heat and resolving phlegm, relieving cough, detoxifying, dissipating nodules and resolving abscesses. It is mainly used to treat wind-heat cough, phlegm-fire cough, scrofula, goiter, sores, lung abscess, breast abscess, etc.

[0029] Scutellaria baicalensis: Bitter in taste, cold in nature. It acts on the lung, gallbladder, spleen, large intestine and small intestine meridians. It has the effects of clearing heat and drying dampness, purging fire and detoxifying, stopping bleeding, and preventing miscarriage. It is mainly used to treat damp-warm syndrome in summer heat, chest distress and nausea, damp-heat stagnation, diarrhea, jaundice, lung heat cough, high fever and restlessness, carbuncles and sores, bleeding due to blood heat, fetal restlessness due to fetal heat, etc.

[0030] Astragalus membranaceus: Sweet in taste, slightly warm in nature. It acts on the spleen and lung meridians. It has the effects of tonifying qi and lifting yang, securing the exterior and stopping sweating, promoting diuresis to alleviate edema, and promoting granulation for sore healing. It is mainly used to treat various syndromes of qi deficiency of the spleen and stomach and qi sinking, qi deficiency of the lung and spontaneous sweating due to exterior deficiency, various syndromes of qi deficiency with exogenous pathogens, qi deficiency edema, dysuria, difficult or non-healing ulcer of carbuncle and sores, etc.

[0031] Codonopsis pilosula: Sweet in taste, neutral in nature. It acts on the spleen and lung meridians. It has the effects of invigorating the spleen and benefiting the lung, nourishing blood and promoting fluid production, etc. It is mainly used to treat qi deficiency of the spleen and lung, injury of qi and fluid, and deficiency of both qi and blood, manifested as pale or sallow complexion, dizziness and palpitations, weakness and fatigue, etc.

[0032] Magnolia officinalis: Bitter and pungent in taste, warm in nature. It acts on the spleen, stomach, lung and large intestine meridians. It has the effects of drying dampness and eliminating phlegm, lowering qi and relieving fullness. It is mainly used to treat dampness blocking the middle-jiao, abdominal distension and fullness, loss of appetite, belching and acid regurgitation, lassitude and loose stools caused by qi stagnation of the spleen and stomach, etc.

[0033] Tangerine peel: Bitter and pungent in taste, warm in nature. It acts on the spleen and lung meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is mainly used to treat abdominal distension and fullness, loss of appetite, vomiting and diarrhea, vomiting, hiccupping, damp phlegm and cold phlegm, excessive cough and phlegm, chest obstruction, etc. caused by qi stagnation of the spleen and stomach and dampness obstruction.

[0034] Poria cocos: Sweet and bland in taste, neutral in nature. It acts on the heart, lung, spleen and kidney meridians. It has the effects of promoting diuresis and percolating dampness, strengthening the spleen, calming the mind and tranquilizing the spirit. It is mainly used to treat edema with oliguria, dizziness and palpitation due to phlegm retention, poor appetite due to spleen deficiency, loose stools and diarrhea, restlessness of the mind, palpitations and insomnia, etc.

[0035] Fresh ginger: Pungent in taste, slightly warm in nature. It acts on the lung, spleen and stomach meridians. It has the effects of inducing sweating to dispel cold, warming the middle-jiao to stop vomiting, resolving phlegm and relieving cough, and detoxifying fish and crab poisoning. It is mainly used to treat mild cases of wind-cold cold, cold syndrome of the spleen and stomach, stomach cold vomiting, cold phlegm cough, fish and crab poisoning, etc.

[0036] Chinese date: Sweet in taste, warm in nature. It acts on the spleen, stomach and heart meridians. It has the effects of replenishing the middle-jiao and boosting qi, nourishing blood and calming the mind, etc. It is mainly used to treat weakness of the spleen qi, emaciation, lassitude and fatigue, loose stools, hysteria, insomnia syndrome, etc.

[0037] Licorice: Sweet in taste, neutral in nature. It acts on the heart, lungs, spleen, and stomach meridians. It has the effects of invigorating the spleen and replenishing qi, clearing heat and detoxifying, resolving phlegm and relieving cough, alleviating spasm and pain, and coordinating various medicinal herbs. It is mainly used to treat spleen-stomach weakness, lassitude and weakness, insufficient qi of the heart, palpitations and shortness of breath, intermittent pulse, carbuncles and sores, sore throat, profuse phlegm and cough, spasmodic pain in the abdomen and limbs, and to relieve the toxicity and potency of drugs, etc.

[0038] The principle and beneficial effects of adopting the above scheme are as follows:

[0039] 1. In this scheme, by carefully combining various medicinal herbs, remarkable therapeutic effects have been achieved. Among them, Mori Cortex and Pinelliae Rhizoma are used as the monarch drugs, playing a core role together. Mori Cortex can clear phlegm-heat in the lungs, relieve asthma and cough, and at the same time promote the excretion of body fluids and reduce edema; Pinelliae Rhizoma has the effects of drying dampness and resolving phlegm, regulating the stomach, relieving adverse qi, and dissipating nodules. The two complement each other and jointly improve the symptoms of the respiratory system.

[0040] Descurainiae Semen, Perillae Fructus, Armeniacae Semen Amarum, and Fritillariae Thunbergii Bulbus are used as ministerial drugs, further enhancing the therapeutic efficacy of the monarch drugs. They act on the lungs together, purging the lungs and descending qi, eliminating phlegm and moistening the lungs, relieving cough and resolving nodules, making the whole prescription more comprehensive and profound in relieving respiratory symptoms.

[0041] Scutellariae Radix, Astragali Radix, Zingiberis Rhizoma Recens, and Codonopsis Radix are used as assistant drugs, which not only clear heat and dry dampness, invigorate qi and consolidate the exterior, replenish middle qi, but also play an important role in regulating the spleen and stomach, providing strong support for the overall curative effect of the prescription.

[0042] Magnoliae Officinalis Cortex, Citri Reticulatae Pericarpium, Poria, and Jujubae Fructus are used as guiding drugs. Their effects of lowering qi and eliminating phlegm, regulating qi and strengthening the spleen, promoting diuresis and percolating dampness, and replenishing middle qi not only help to coordinate various medicinal herbs, but also make the whole prescription more advantageous in improving the internal environment of the body and promoting recovery.

[0043] Licorice, as one of the guiding drugs, has the dual functions of coordinating various medicinal herbs and relieving cough and spasm. It has a significant adjuvant effect on relieving cough symptoms, can balance the properties of the whole prescription, and make the overall curative effect more stable. The joint use of these medicinal herbs can not only effectively remove phlegm, relieve cough and asthma, but also embody the treatment concept of "combining the method of drying dampness with the method of promoting qi movement" in traditional Chinese medicine. By regulating the function of the spleen and stomach, the source of phlegm generation is fundamentally eliminated. The whole prescription uses medicine sparingly but has remarkable effects, providing strong support for the treatment of related ARDS diseases.

[0044] 2. In this solution, the traditional Chinese medicinal materials are respectively crushed into particles that pass through a 4-mesh sieve and do not pass through a 10-mesh sieve, which is beneficial to the full release of the active ingredients of the traditional Chinese medicinal materials during the decocting process and improves the efficacy of the preparation. At the same time, grinding the medicinal materials in separate chambers avoids cross-contamination between different medicinal materials and ensures the purity of the preparation. By steps such as soaking in water, decocting, filtering, and volume fixing, the preparation process of the traditional Chinese medicine preparation is precisely controlled. The decocting method of first using high heat and then slow fire not only ensures that the active ingredients of the traditional Chinese medicinal materials can be fully dissolved in water, but also avoids damaging the active ingredients of the medicinal materials due to excessive temperature. Secondary decocting and membrane filtration further improve the purity and efficacy of the preparation.

[0045] 3. In this solution, by setting a crushing component with electric rotating shafts of different speeds, the traditional Chinese medicinal materials can be grouped and crushed according to their characteristics (such as toughness, particle size, etc.). This personalized processing method not only improves the crushing efficiency, but also ensures the appropriate particle size of different traditional Chinese medicinal materials before decocting, which is beneficial to the full release of the efficacy. For example, for tough traditional Chinese medicinal materials such as mulberry bark and tangerine peel, strong cutting is adopted; while for traditional Chinese medicinal materials with small or fragile particles such as perilla seeds, slight cutting is carried out. This design makes the pretreatment of traditional Chinese medicinal materials more scientific and reasonable.

[0046] 4. In this solution, an intelligent recovery system composed of a filter screen and a pressure sensor can automatically detect and recover the crushed residues of traditional Chinese medicinal materials and the incompletely ground traditional Chinese medicine residues. This not only reduces the waste of medicinal materials, but also facilitates subsequent secondary grinding or processing. At the same time, by using an air pump to blow the residues into the recovery box, automated operation is achieved, improving the work efficiency.

[0047] 5. In this solution, the crushed traditional Chinese medicinal material particles are evenly dispersed into the decocting tank through a conveying component, avoiding the problem of bottom burning caused by the accumulation of traditional Chinese medicine particles at the bottom during the traditional decocting process. Especially through the setting of the conveying pipe and the first and second discharge ports, the uniform mixing of traditional Chinese medicine particles and the medicinal liquid is achieved, ensuring the uniformity of decocting and the full exertion of the efficacy. The stirring component drives the scraper to rotate through a servo motor, which not only stirs the bottom medicinal liquid, but also scrapes up the traditional Chinese medicine particles that sink to the bottom of the decocting tank, effectively preventing the occurrence of bottom burning. At the same time, this stirring method also reduces the residue left in the decocting tank, improving the utilization rate and efficacy of traditional Chinese medicine.

[0048] Additional aspects and advantages of the present invention will be given in part in the following description, will become apparent in part from the following description, or will be understood through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 It is a schematic diagram of the method steps of the embodiment of the traditional Chinese medicine preparation for treating ARDS and its preparation method of the present invention;

[0050] Figure 2Axonometric schematic diagram of the decocting device for the traditional Chinese medicine preparation for treating ARDS and its preparation method according to the present invention;

[0051] Figure 3 Front sectional view schematic diagram of the decocting device for the traditional Chinese medicine preparation for treating ARDS and its preparation method according to the present invention.

[0052] Reference numerals in the accompanying drawings of the specification include: 1, tank body; 2, transparent window; 3, crushing chamber; 4, first conveying cylinder; 5, feeding port; 6, first straight cylinder; 7, sliding chute; 8, recycling box; 9, blade; 10, electric rotating shaft; 11, feeding channel; 12, air pump; 13, second straight cylinder; 14, second conveying cylinder; 15, water delivery pipe; 16, tank cover; 17, decocting tank; 18, electric heating wire; 19, conveying pipe; 20, servo motor; 21, transmission rod; 22, scraper; 23, air outlet duct. Detailed implementation manners

[0053] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0054] In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. is based on the orientation or positional relationship shown in the accompanying drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention. In addition, the terms "first", "second", "third" are only used for descriptive purposes and cannot be construed as indicating or implying relative importance.

[0055] In the description of the present invention, it should be noted that unless otherwise clearly specified and limited, the terms "installation", "connection", "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0056] The following is further detailed through specific implementation manners:

[0057] Example 1:

[0058] A traditional Chinese medicine preparation for treating ARDS, comprising the following components in parts by weight: 20-40 parts of cortex mori, 15-35 parts of pinellia ternata, 15-20 parts of semen lepidii, 5-10 parts of semen brassicae, 5-10 parts of apricot kernel, 5-10 parts of fritillaria cirrhosa, 15-25 parts of scutellaria baicalensis, 8-10 parts of astragalus membranaceus, 8-10 parts of codonopsis pilosula, 3-5 parts of magnolia officinalis, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of poria cocos, 1-3 parts of ginger, 10-12 parts of jujube and 10-12 parts of licorice root.

[0059] Example 2:

[0060] The difference from Example 1 lies in that a traditional Chinese medicine preparation for treating ARDS, comprising the following components in parts by weight: 20 parts of cortex mori, 15 parts of pinellia ternata, 15 parts of semen lepidii, 5 parts of semen brassicae, 5 parts of apricot kernel, 5 parts of fritillaria cirrhosa, 10 parts, 15 parts of scutellaria baicalensis, 8 parts of astragalus membranaceus, 8 parts of codonopsis pilosula, 3 parts of magnolia officinalis, 5 parts of pericarpium citri reticulatae, 5 parts of poria cocos, 1 part of ginger, 10 parts of jujube and 10 parts of licorice root.

[0061] Example 3:

[0062] The difference from Example 2 lies in that a traditional Chinese medicine preparation for treating ARDS, comprising the following components in parts by weight: 30 parts of cortex mori, 25 parts of pinellia ternata, 18 parts of semen lepidii, 8 parts of semen brassicae, 7 parts of apricot kernel, 7 parts of fritillaria cirrhosa, 12 parts, 20 parts of scutellaria baicalensis, 9 parts of astragalus membranaceus, 9 parts of codonopsis pilosula, 4 parts of magnolia officinalis, 8 parts of pericarpium citri reticulatae, 7 parts of poria cocos, 2 parts of ginger, 11 parts of jujube and 11 parts of licorice root.

[0063] Example 4:

[0064] The difference from Example 3 lies in that a traditional Chinese medicine preparation for treating ARDS, comprising the following components in parts by weight: 40 parts of cortex mori, 35 parts of pinellia ternata, 10 parts of semen brassicae, 10 parts of apricot kernel, 10 parts of fritillaria cirrhosa, 15 parts, 25 parts of scutellaria baicalensis, 10 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 5 parts of magnolia officinalis, 10 parts of pericarpium citri reticulatae, 10 parts of poria cocos, 3 parts of ginger, 12 parts of jujube and 12 parts of licorice root.

[0065] Example 5:

[0066] As shown in the appendix Figure 1 The difference from Example 4 lies in that a preparation method of a traditional Chinese medicine preparation for treating ARDS, characterized by comprising the following steps:

[0067] Step 1, cleaning traditional Chinese medicine: Weigh cortex mori, pinellia ternata, semen lepidii, semen brassicae, apricot kernel, fritillaria cirrhosa, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, magnolia officinalis, pericarpium citri reticulatae, poria cocos, ginger, jujube and licorice root according to parts by weight, remove the moth-eaten and rotten parts, wash them with clean water and then rinse them with sterile distilled water.

[0068] Step 2, raw material treatment: Place cortex mori, pinellia ternata, semen lepidii, semen perillae, apricot kernels, fritillaria thunbergii, scutellaria baicalensis, astragalus membranaceus, codonopsis pilosula, magnolia officinalis, pericarpium citri reticulatae, poria cocos, fresh ginger, Chinese dates and licorice root in a decocting device and crush them separately to obtain traditional Chinese medicine granules. The diameter of the crushed traditional Chinese medicine granules is that they pass through a 4-mesh sieve and do not pass through a 10-mesh sieve.

[0069] Step 3, preparation of decoction: Place the traditional Chinese medicine granules in a decocting device, soak them in water for 60 minutes and then decoct. First, use strong fire to boil until boiling, and then adjust the power of the decocting device to slow fire to keep the liquid medicine boiling but the liquid surface without undulation for 30 minutes. After filtration, obtain the first decoction and the residue respectively. Add water to the residue and decoct again. After boiling for 20 minutes in the second decoction, filter to obtain the second filtrate. Mix the second filtrate with the first decoction to obtain the decoction. Add the decoction into a volumetric flask, make up the volume with methanol, vortex and mix evenly, filter with a filter membrane, the pore diameter of the filter membrane is 0.45 μm, collect the filtrate, and thus obtain the traditional Chinese medicine preparation for treating ARDS.

[0070] Example 6:

[0071] As shown in Figure 2 and Figure 3 shown, the difference from Example 5 is that in Steps 2 and 3, the decocting device includes a tank body 1. A crushing cavity 3 is fixedly connected to the top of the tank body 1. A crushing component for crushing traditional Chinese medicine materials and recovering the crushed traditional Chinese medicine residues is arranged in the crushing cavity 3. A feeding component is communicated with the top of the crushing cavity 3. A decocting component for decocting traditional Chinese medicine materials is arranged in the tank body 1. The decocting component is signal-connected to a controller. A conveying component for conveying the crushed traditional Chinese medicine granules is arranged in the decocting component. The conveying components are all communicated with the crushing cavity 3. A stirring component for stirring the decoction and preventing the medicinal residues from sinking to the bottom is fixedly connected to the bottom of the conveying component.

[0072] A first partition is provided in the crushing chamber 3, and the first partition divides the crushing chamber 3 into a crushing layer and a conveying layer from top to bottom. The feeding assembly includes a first straight cylinder 6 fixedly connected to the top of the first partition, and a first conveying cylinder 4 fixedly connected to the top of the first partition is provided outside the first straight cylinder 6. A first conveying channel is provided between the first straight cylinder 6 and the first conveying cylinder 4, and a plurality of second partitions are fixedly connected between the first straight cylinder 6 and the first conveying cylinder 4. The second partition divides the first conveying channel into a plurality of feeding channels 11. The tops of the feeding channels 11 are all provided with feeding ports 5 connected to the outside. First, different medicinal materials are respectively fed through the feeding ports 5. Since Chinese medicinal materials such as Morus alba, Magnolia officinalis, Codonopsis pilosula and Tangerine peel are tough, they require strong cutting. Capacity, so mulberry bark, magnolia bark and tangerine peel can be put into the same feeding channel 11 for grinding and chopping, while perilla seed and scutellaria seed have small particle diameters and require little grinding and chopping force, so they enter a feeding channel 11 alone for light chopping and sieving before being added to the decoction component. Ginger itself has a spicy smell and is not easy to be chopped, so it also enters one of the feeding channels 11 alone for strong chopping and crushing, and is transported to the decoction component together with the ginger juice. Fruit-like medicinal materials such as pinellia, fritillaria, almond and jujube can be put into the same feeding channel 11 for chopping, and block and sheet medicinal materials such as tuckahoe, scutellaria, astragalus and licorice can also be classified as the same category and put into the feeding channel 11 for grinding and chopping.

[0073] A plurality of electric rotating shafts 10 corresponding to the feeding channels 11 are arranged in the crushing layer, and the electric rotating shafts 10 are all connected to the controller signal. A plurality of blades 9 are fixedly connected to the electric rotating shafts 10. According to the grouping of the Chinese medicinal materials before feeding, the rotation speed of the electric rotating shafts 10 in different feeding channels 11 is controlled by the controller.

[0074] A plurality of filters and pressure sensors are arranged on the partition, and the filters and pressure sensors are both located in each feeding channel 11, and the aperture of the filters is less than 4 meshes and greater than 10 meshes. After grinding and cutting, the Chinese medicine particles pass through the filters, and a plurality of recovery boxes 8 are arranged on the side of the crushing layer away from the first straight cylinder 6, and the recovery boxes 8 correspond to the feeding channels 11 one by one. An air pump 12 is arranged in the first straight cylinder 6, and an air outlet 23 connecting the interior of the first straight cylinder 6 and the feeding channel 11 is arranged on the first straight cylinder 6. The air pump 12 and the pressure sensor are connected to the control The pressure sensor is connected to the controller signal, and the pressure sensor can sense the weight change above the filter. When the ground Chinese medicine particles pass through the filter, the weight above the filter becomes smaller, and the signal is transmitted to the controller through the pressure sensor to start the air pump 12. The wind from the air pump 12 passes through the air outlet 23 and blows the slag and incompletely ground Chinese medicine residues above the filter in each feeding channel 11 into the recovery box 8. The incompletely ground Chinese medicine residues are sorted out by taking out the recovery box 8 for secondary grinding, and the slag is recovered.

[0075] A transparent window 2 is also hinged to the tank body 1. The decocting assembly includes a decocting pot 17 fixedly connected to the inner bottom wall of the tank body 1. A transparent pot cover 16 is hinged to the top of the decocting pot 17. The decocting pot 17 is communicated with a water delivery pipe 15. One end of the water delivery pipe 15 away from the decocting pot 17 extends to the outside of the tank body 1 and is communicated with a water tank. Through the water tank and the water delivery pipe 15, the addition of pure water can be realized without opening the pot cover 16. A plurality of electric heating wires 18 are arranged in the interlayer of the decocting pot 17. The electric heating wires 18 are all connected to the controller in a signal manner. The electric heating wires 18 are used to heat the decocting pot 17. And the electric heating wires 18 arranged in the interlayer of the decocting pot 17 can uniformly heat the decocting pot 17, avoiding the situation that the traditional Chinese medicine particles overheat and accumulate at the bottom due to only heating from the bottom. Since it is necessary to constantly pay attention to the boiling situation of the liquid medicine in the decocting pot 17 during the decocting process, the interior of the decocting pot 17 can be directly observed through the transparent window 2 and the transparent pot cover 16. Under the preset condition of the controller, the heating power and decocting time of the electric heating wires 18 can also be adjusted manually by using the controller.

[0076] The conveying assembly includes a second straight cylinder 13 and a second conveying cylinder 14 located outside the second straight cylinder 13. The tops of the second straight cylinder 13 and the second conveying cylinder 14 both extend into the conveying layer and are fixedly connected to the bottom of the first partition board. A second conveying channel is arranged between the second conveying cylinder 14 and the second straight cylinder 13. A plurality of third partition boards are fixedly connected between the second straight cylinder 13 and the second conveying cylinder 14. The third partition boards divide the second conveying channel into a plurality of feeding channels. The feeding channels correspond to the feeding channels 11 one by one. A sliding chute 7 is communicated between the feeding channel and the feeding channel 11. After the traditional Chinese medicine in the crushing cavity 3 is ground, the traditional Chinese medicine particles enter the feeding channel through the sliding chute 7 and vertically fall to the bottom of the feeding channel.

[0077] The bottoms of the second conveying cylinder 14 and the second straight cylinder 13 both extend into the decocting pot 17. A plurality of conveying pipes 19 are fixedly connected to the outside of the second conveying cylinder 14. The conveying pipes 19 correspond to the feeding channels and are communicated with each other. A plurality of first discharge ports are opened at one ends of the conveying pipes 19 away from the feeding channels. A plurality of second discharge ports corresponding to the feeding channels are opened at the bottom of the first conveying cylinder 4. In the traditional decocting process of traditional Chinese medicine, since the traditional Chinese medicine particles are added into the decocting pot 17 at the same time, under the influence of gravity, most of the traditional Chinese medicine particles will sink to the bottom, resulting in the accumulation of traditional Chinese medicine particles at the bottom of the decocting pot 17 and causing bottom burning. Therefore, in the present invention, the second discharge port communicates the conveying pipe 19 with the decocting pot 17. The traditional Chinese medicine particles that first fall to the bottom of the first conveying cylinder 4 can be dispersed into the liquid medicine located in the conveying pipe 19 through the first discharge port. And since the second discharge port is also opened at the bottom of the conveying pipe 19, it is possible to avoid excessive injection of the liquid medicine into the first conveying cylinder 4, realizing uniform mixing while avoiding the influence of the liquid medicine on the conveying assembly.

[0078] The stirring assembly includes a motor box fixedly connected inside the second straight cylinder 13. At the top inside the motor box, a servo motor 20 is fixedly connected. An insulating layer for isolating the motor box from the high temperature of the external liquid medicine is provided on the inner wall of the second straight cylinder 13. A transmission rod 21 is coaxially and fixedly connected to the output shaft of the servo motor 20. One end of the transmission rod 21 extends into the decocting tank 17 and is fixedly connected with a plurality of scrapers 22. The servo motor 20 is in signal connection with the controller. Since some Chinese medicine particles with relatively large mass will still fall to the bottom of the decocting tank 17 under the influence of gravity, therefore, the controller is used to start the transmission rod 21 to drive the scrapers 22 to rotate. While stirring the liquid medicine at the bottom to fully dissolve the Chinese medicine particles in the liquid medicine, the Chinese medicine particles settled at the bottom can be scraped up from the bottom of the decocting tank 17, preventing the decocting tank 17 from sticking to the bottom. At the same time, the Chinese medicine particles are utilized, reducing the residue left in the decocting tank 17 and improving the utilization rate of Chinese medicinal materials.

[0079] Obviously, the above embodiments are only examples given for clear illustration and not limitations on the implementation manners. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. And the obvious changes or modifications derived therefrom are still within the protection scope of the present invention.

Claims

1. A Chinese medicine preparation for treating ARDS, characterized in that: The invention comprises the following components in parts by weight: 20-40 parts of mulberry bark, 15-35 parts of pinellia tuber, 15-20 parts of scutellaria baicalensis, 5-10 parts of apricot kernel, 5-10 parts of fritillaria frittata, 15-25 parts of scutellaria baicalensis, 8-10 parts of astragalus, 8-10 parts of codonopsis pilosula, 3-5 parts of magnolia bark, 5-10 parts of tangerine peel, 5-10 parts of poria, 1-3 parts of ginger, 10-12 parts of jujube and 10-12 parts of liquorice.

2. The Chinese medicine preparation for treating ARDS according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 20 parts of mulberry bark, 15 parts of pinellia tuber, 15 parts of scutellaria baicalensis, 5 parts of perilla seed, 5 parts of apricot kernel, 5 parts of fritillaria thunbergii, 10 parts of scutellaria baicalensis, 8 parts of astragalus, 8 parts of codonopsis pilosula, 3 parts of magnolia bark, 5 parts of tangerine peel, 5 parts of poria, 1 part of ginger, 10 parts of jujube and 10 parts of liquorice.

3. The Chinese medicine preparation for treating ARDS according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 30 parts of mulberry bark, 25 parts of pinellia tuber, 18 parts of scutellaria baicalensis, 8 parts of perilla seed, 7 parts of apricot kernel, 7 parts of fritillaria bulb, 12 parts of scutellaria baicalensis, 9 parts of astragalus, 9 parts of codonopsis pilosula, 4 parts of magnolia bark, 8 parts of tangerine peel, 7 parts of poria, 2 parts of ginger, 11 parts of jujube and 11 parts of liquorice.

4. The Chinese medicine preparation for treating ARDS according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 40 parts of mulberry bark, 35 parts of pinellia tuber, 10 parts of perilla seed, 10 parts of apricot kernel, 10 parts of fritillaria, 15 parts of scutellaria baicalensis, 10 parts of astragalus, 10 parts of codonopsis pilosula, 5 parts of magnolia bark, 10 parts of tangerine peel, 10 parts of poria, 3 parts of ginger, 12 parts of jujube and 12 parts of liquorice.

5. A method for preparing a traditional Chinese medicine preparation for treating ARDS according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step 1, cleaning the Chinese medicine: weigh mulberry bark, pinellia, scutellaria, perilla, apricot, fritillaria, scutellaria, astragalus, codonopsis, magnolia bark, tangerine peel, poria, ginger, jujube and liquorice according to weight, remove the borers and rotten parts, wash with clean water and then rinse with sterile distilled water; Step 2, raw material processing: placing mulberry bark, pinellia tuber, scutellaria baicalensis, perilla seed, apricot kernel, fritillaria, scutellaria baicalensis, astragalus, codonopsis pilosula, magnolia bark, tangerine peel, poria, ginger, jujube and liquorice in a decoction device and crushing them separately to obtain Chinese medicine granules; Step three, preparing a decoction: placing the Chinese medicine particles in a decoction device, soaking them in water and then decocting them, filtering them to obtain a first decoction and a filter residue respectively, adding water to the filter residue and decocting them again, filtering them after the second decoction to obtain a secondary filtrate, mixing the secondary filtrate with the first decoction to obtain a decoction, adding the decoction to a volumetric flask, vortex mixing, filtering the filtrate with a filter membrane to obtain a Chinese medicine preparation for the treatment of ARDS.

6. The method for preparing a Chinese medicine preparation for treating ARDS according to claim 5, characterized in that: In step 2, the diameter of the crushed Chinese medicine particles is such that they can pass through a 4-mesh sieve but not through a 10-mesh sieve.

7. The method for preparing a Chinese medicine preparation for treating ARDS according to claim 6, characterized in that: In step three, the soaking time in water is 60 minutes. When decocting, first boil it with high heat until it boils, and then adjust the power of the decoction device to low heat to keep the medicine liquid boiling but the liquid level without fluctuation for 30 minutes. The second decoction boiling time is 20 minutes.

8. The method for preparing a traditional Chinese medicine preparation for treating ARDS according to claim 7, characterized in that: In step 3, the decoction is added to a volumetric flask and then fixed to volume with methanol. After vortex mixing, the pore size of the filter membrane used is 0.45 μm.

9. The method for preparing a traditional Chinese medicine preparation for treating ARDS according to claim 8, characterized in that: In step 2 and step 3, the decoction device comprises a tank body (1), the top of the tank body (1) is fixedly connected to a grinding chamber (3), a grinding component for grinding Chinese medicinal materials and recovering the residue of the ground Chinese medicinal materials is arranged in the grinding chamber (3), the top of the grinding chamber (3) is connected to a feeding component, a decoction component for decocting Chinese medicinal materials is arranged in the tank body (1), the decoction component signal is connected to a controller, a conveying component for conveying the ground Chinese medicinal material particles is arranged in the decoction component, the conveying components are all connected to the grinding chamber (3), and a stirring component for stirring the decoction and preventing the residue from sinking to the bottom is fixedly connected to the bottom of the conveying component.

10. The method for preparing a Chinese medicine preparation for treating ARDS according to claim 9, characterized in that: A first partition is provided in the pulverizing chamber (3), and the first partition divides the pulverizing chamber (3) into a pulverizing layer and a conveying layer from top to bottom. The feeding assembly comprises a first straight cylinder (6) fixedly connected to the top of the first partition, a first conveying cylinder (4) fixedly connected to the top of the first partition is provided outside the first straight cylinder (6), a first conveying channel is provided between the first straight cylinder (6) and the first conveying cylinder (4), a plurality of second partitions are fixedly connected between the first straight cylinder (6) and the first conveying cylinder (4), the second partition divides the first conveying channel into a plurality of feeding channels (11), the tops of the feeding channels (11) are all provided with feeding ports (5) connected to the outside, and a plurality of feeding ports (5) connected to the feeding channels (11) are provided in the pulverizing layer. 11), the electric rotating shafts (10) are all connected to the controller signal, a plurality of blades (9) are fixedly connected to the electric rotating shafts (10), a plurality of filter screens and pressure sensors are provided on the partition, the filter screens and pressure sensors are both located in each feeding channel (11), a plurality of recovery boxes (8) are provided on the side of the crushing layer away from the first straight cylinder (6), the recovery boxes (8) are all in one-to-one correspondence with the feeding channels (11), an air pump (12) is provided in the first straight cylinder (6), an air outlet duct (23) connecting the interior of the first straight cylinder (6) and the feeding channel (11) is provided on the first straight cylinder (6), and the air pump (12) and the pressure sensor are both connected to the controller signal; A transparent window (2) is also hingedly connected to the tank body (1). The boiling assembly comprises a boiling pot (17) fixedly connected to the inner bottom wall of the tank body (1). A transparent pot cover (16) is hingedly connected to the top of the boiling pot (17). The boiling pot (17) is connected to a water pipe (15). One end of the water pipe (15) away from the boiling pot (17) extends to the outside of the tank body (1) and is connected to a water tank. A plurality of electric heating wires (18) are arranged in the interlayer of the boiling pot (17). The electric heating wires (18) are all connected to the controller signal. The conveying assembly comprises a second straight cylinder (13) and a second conveying cylinder (14) located outside the second straight cylinder (13); the top ends of the second straight cylinder (13) and the second conveying cylinder (14) extend into the conveying layer and are fixedly connected to the bottom of the first partition; a second conveying channel is provided between the second conveying cylinder (14) and the second straight cylinder (13); a plurality of third partitions are fixedly connected between the second straight cylinder (13) and the second conveying cylinder (14); the third partitions divide the second conveying channel into a plurality of feeding channels; the feeding channels correspond to the feeding channels (11) one by one; and the feeding channels are connected to the feeding channels (11) via a sliding groove (7); The bottom ends of the second conveying cylinder (14) and the second straight cylinder (13) both extend into the interior of the decoction pot (17), and a plurality of conveying pipes (19) are fixedly connected to the outside of the second conveying cylinder (14), the conveying pipes (19) all correspond to the feed channels and are interconnected, a plurality of first discharge ports are formed at one end of the conveying pipes (19) away from the feed channels, and a plurality of second discharge ports corresponding to the feed channels are formed at the bottom of the first conveying cylinder (4); The stirring assembly comprises a motor box fixedly connected to the inside of the second straight cylinder (13), a servo motor (20) is fixedly connected to the top of the motor box, an inner wall of the second straight cylinder (13) is provided with a heat insulation layer for isolating the motor box from the high temperature of the external medicine liquid, a transmission rod (21) is coaxially fixedly connected to the output shaft of the servo motor (20), one end of the transmission rod (21) extends into the decoction pot (17) and is fixedly connected to a plurality of scrapers (22), and the servo motor (20) is connected to the controller signal.

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