Preparation method and preparation equipment of skin antipruritic

Abstract

The invention provides a preparation method and preparation equipment of a skin antipruritic, relates to the technical field of preparation of skin antipruritic, and aims to solve the problems of poor material isolation and poor mixing effect of existing equipment. Through cooperation of the conveying pipe, the mixing kettle, the central pipe, the charging barrel and the movable plate, efficient loading and mixing of solid and liquid raw materials are achieved, the mixing effect is improved, and the separation and cleaning process is simplified. The motor, the gear, the belt and the rotating shaft are matched to enable the charging barrel to rotate to accelerate reaction, and the fixed plate ensures stable operation. The electric control box accurately controls temperature, the display screen displays in real time, the electric control button is convenient to control, and equipment safety is guaranteed. The universal wheels facilitate movement of the device, and the cooling fan prolongs the service life of the device. According to the preparation method, the raw materials are scientifically pretreated, mixing is accurately controlled through equipment, the prepared antipruritic can effectively relieve skin itch, and a better scheme is brought to production of the skin antipruritic.

Description

Technical Field

[0001] The present invention belongs to the technical field related to pharmaceutical preparation equipment, and particularly relates to a preparation method and preparation equipment for a skin antipruritic agent. Background Art

[0002] Skin itching, as a common skin problem, plagues many people in daily life. When the skin is subjected to various stimuli such as physical stimuli (such as friction, cold and heat changes), chemical stimuli (such as contact with allergens, irritating substances), and biological factors (such as mosquito bites, microbial infections), itching will occur. Usually, this symptom is also accompanied by abnormal conditions such as swelling and inflammation. In severe cases, it may even further induce allergic reactions, leading to microbial parasitism, and ultimately causing skin ulceration, greatly affecting the quality of life and physical health of patients.

[0003] To relieve skin itching symptoms, skin antipruritic agents have emerged. Such drugs or products mainly play a role by reducing irritation, inhibiting inflammation or sedating the skin, and have become a key means to solve skin itching problems. The preparation equipment for skin antipruritic agents, as an important machine and tool for producing various dosage forms of antipruritic products, its performance directly relates to the product quality. High-quality preparation equipment can ensure that the product meets high-quality standards during the preparation process, meets the strict requirements of safety and effectiveness, and plays a decisive role in ensuring the efficacy of skin antipruritic agents.

[0004] However, in the current field of skin antipruritic agent preparation, there are many problems to be solved urgently in the existing preparation equipment. On the one hand, the material isolation effect is poor. During the mixing process, once solid-liquid substances are mixed, it is difficult to achieve good separation, which not only increases the difficulty of subsequent processing but also may affect the purity and quality of the product. On the other hand, the simple and rough treatment process results in an unsatisfactory material mixing effect, and the components cannot be fully fused and reacted, thereby greatly reducing the antipruritic effect of the final product. These problems seriously restrict the production efficiency and product quality of skin antipruritic agents and urgently need to be solved through innovative preparation methods and advanced preparation equipment. Summary of the Invention

[0005] The purpose of the present invention is to provide a preparation method and preparation equipment for a skin antipruritic agent to solve the problems raised in the above background art.

[0006] To achieve the above purpose, the present invention provides the following technical solutions: A preparation method and preparation equipment for a skin antipruritic agent, including a machine body and a bottom plate provided at the bottom of the machine body;

[0007] Universal wheels are respectively provided at the four corners of the bottom of the base plate. A heat dissipation fan and an electric control box are provided on the side of the machine body. A plurality of electric control buttons and a display screen are provided on the electric control box. A feed pipe is provided on the top of the machine body. A material conveying pipe is provided below the feed pipe. A reaction tank is provided below the material conveying pipe. A transmission pipe is provided on the side of the reaction tank. The other end of the transmission pipe is provided with a mixing kettle. A fixing hoop is provided on the outside of the mixing kettle;

[0008] A top cover is provided on the top of the mixing kettle. A discharge pipe is provided on the top cover. A central pipe is provided in the middle of the mixing kettle. A charging bucket is provided on the outside of the central pipe. Fixing rings are respectively provided at the top and bottom of the central pipe. Fixing plates are respectively provided on both sides of the fixing ring. A rotating shaft is provided at the bottom of the central pipe. A gear is provided at the bottom of the rotating shaft. A motor is provided on the front of the machine body. The motor is externally connected to a power supply for power supply.

[0009] Preferably, the motor is fixedly installed on the machine body by screws. A gear is also provided on the motor. The gear is fixedly connected to the output shaft of the motor.

[0010] Preferably, the rotating shaft is welded to the gear. A belt is provided between the two gears. The gears can be driven by the belt.

[0011] Preferably, the central pipe is welded to the rotating shaft. The outer wall of the central pipe is a porous and hollow structure. The charging bucket is welded to the central pipe. A movable plate is provided on the top of the charging bucket. The movable plate is movably connected to the charging bucket through a hinge. Solid raw materials can be loaded into the charging bucket through the movable plate.

[0012] Preferably, the fixing ring is sleeved on the central pipe. A clamping block is provided on the inner side of the fixing ring. The clamping block can be mutually clamped with the clamping groove on the central pipe. The central pipe can rotate on the two fixing rings.

[0013] Preferably, the fixing plate is welded to the fixing ring. The fixing plate is welded to the mixing kettle. The fixing plate can support the fixing ring and the central pipe.

[0014] Preferably, the discharge pipe penetrates through the top cover and is communicated with the mixing kettle. The transmission pipe is welded to the mixing kettle. The substances inside the reaction tank can flow into the mixing kettle through the transmission pipe.

[0015] Preferably, the electric control box can control the reaction temperature of the reaction tank and the mixing kettle. The display screen can display the temperature. The electric control buttons can control the switch and emergency stop of the machine body.

[0016] A preparation method of a skin antipruritic agent, the preparation method steps are as follows:

[0017] Step 1: Raw material pretreatment

[0018] Treatment of fresh sesame flowers:

[0019] Take 80 - 160 g of fresh sesame flowers, quickly place them in a low - temperature environment for rapid freezing, control the freezing temperature at - 20°C to - 30°C, and the freezing time is 1 - 2 hours to retain their active ingredients to the greatest extent;

[0020] Put the frozen fresh sesame flowers into a gradient alcohol purification device, and use alcohol with a concentration gradually increasing from 30% to 70% for gradient purification. The soaking time for each purification is 2 - 3 hours, and finally, through conventional purification processes such as filtration and distillation, retain the extract;

[0021] Treatment of honeysuckle, cloves, and nutmeg:

[0022] Weigh 6 - 15 g of honeysuckle, 5 - 15 g of cloves, and 5 - 15 g of nutmeg respectively, and put them together into a clean and well - sealed container;

[0023] Pour sufficient 70% alcohol into the container to ensure that the raw materials are completely submerged, and the soaking time lasts for 24 - 36 hours. During this period, gently shake the container every 4 - 6 hours to make the soaking more uniform;

[0024] After the soaking is completed, remove the alcohol through a filtration device, and collect and retain the leachate;

[0025] Treatment of cortex dictamni, pomegranate peel, tsaoko fruit, tsaoko amomum, and astragalus membranaceus:

[0026] Accurately weigh each raw material according to the amounts of 8 - 16 g of cortex dictamni, 6 - 15 g of pomegranate peel, 5 - 10 g of tsaoko fruit, 5 - 15 g of tsaoko amomum, and 8 - 16 g of astragalus membranaceus;

[0027] Put the above - mentioned raw materials into a container filled with an appropriate amount of low - temperature water, and the soaking time is 12 - 24 hours. During this period, stir appropriately as well;

[0028] After the soaking is completed, use a filtration device to separate the extract;

[0029] Step Two: Mixing of Raw Materials

[0030] Equipment Preparation:

[0031] Check whether each component of the skin antipruritic agent preparation equipment is normal, ensure that the universal wheels can rotate flexibly, the cooling fan is running normally, the electric control buttons and display screen on the electric control box are functioning properly, and the motor can be normally externally powered and started;

[0032] Open the top cover of the mixing kettle, load the pretreated solid raw materials into the charging bucket through the movable plate. After loading, close the movable plate to ensure sealing;

[0033] Addition of Liquid Raw Materials:

[0034] The honeysuckle, clove, nutmeg extracts obtained after alcohol soaking treatment and the dictamnus bark, pomegranate peel, tsaoko fruit, tsaoko amomum, astragalus root extracts obtained by low-temperature water extraction are preliminarily mixed in a reaction tank with an appropriate amount of ointment, water or other selected solvents according to a ratio. During the mixing process, the temperature of the reaction tank can be controlled by an electric control box and maintained at 30°C - 40°C, and the mixture is stirred for 10 - 15 minutes through a stirring device in the reaction tank to ensure uniform mixing;

[0035] Open the valve on the transfer pipe, and the mixed liquid raw materials in the reaction tank flow into the bottom of the mixing kettle through the transfer pipe. Since the outer wall of the central pipe is a porous and hollow structure, the liquid raw materials will pass through the holes and enter the charging bucket, making full contact with the solid raw materials;

[0036] Step Three: Mixing and Stirring

[0037] Start the motor. The motor drives the gear on it to rotate through the output shaft. The gear is driven by a belt to drive the rotating shaft to rotate, and then drives the central pipe and the charging bucket to rotate synchronously;

[0038] The rotation of the charging bucket enables the solid raw materials and liquid raw materials inside to be fully mixed during continuous tumbling. The stirring time is set to 30 - 60 minutes. During this period, the temperature inside the mixing kettle can be monitored through the electric control box and the display screen. If the temperature is too high, the cooling fan will automatically start to cool down to ensure that the mixing process is carried out under suitable temperature conditions to improve the reaction efficiency of the solid raw materials and liquid raw materials;

[0039] Step Four: Finished Product Discharge

[0040] After mixing is completed, turn off the motor and stop stirring;

[0041] Open the valve of the discharge pipe on the top cover of the mixing kettle, and discharge the prepared finished product of the skin antipruritic agent through the discharge pipe and collect it into a pre-prepared clean and sealed container;

[0042] Clean the equipment. Open the top cover of the mixing kettle, take out the residual raw materials in the charging bucket, and rinse the reaction tank, mixing kettle, and central pipe components with clean water to ensure the cleanliness of the equipment and prepare for the next preparation.

[0043] Compared with the prior art, the present invention provides a preparation method and a preparation device for a skin antipruritic agent, having the following beneficial effects:

[0044] Through the collaborative design of a transfer pipe, a mixing kettle, a central pipe, a charging bucket, and a movable plate, the present invention achieves the efficient loading and mixing of solid and liquid raw materials. The movable plate is convenient to open, enabling the rapid loading of solid raw materials into the charging bucket. The liquid raw materials flow in from the bottom of the mixing kettle through the transfer pipe and enter the charging bucket through the holes on the outer wall of the central pipe, coming into full contact with and soaking the solid raw materials. This solid-liquid separation design greatly improves the mixing effect of the raw materials, and at the same time significantly simplifies the separation and cleaning process of solids and liquids in the mixing kettle, making the operation more convenient and greatly improving the production efficiency.

[0045] Through the ingenious combination of gears, belts, motors, and rotating shafts, the present invention endows the charging bucket and the central pipe with a rotating function. When the motor starts, it drives the gears to rotate, which in turn drives the rotating shafts through the belts, thereby enabling the charging bucket and the central pipe to rotate synchronously. This rotation mechanism promotes the full mixing of solid and liquid raw materials in the charging bucket, accelerates the reaction process, and effectively improves the reaction efficiency. At the same time, the settings of the fixing plate, fixing ring, and clamping block ensure the stability of the central pipe during rotation. The fixing ring is firmly fixed inside the mixing kettle through the fixing plates on both sides, providing a solid guarantee for the stable operation of the device, enabling the equipment to maintain a stable working state during long-term operation, and reducing the risk of failures caused by component shaking.

[0046] Through the electric control box, the present invention can accurately control the reaction temperature of the reaction tank and the mixing kettle. The display screen shows the temperature in real time, facilitating the operators to grasp the operating state of the equipment and the reaction process at any time, adjust the parameters in a timely manner, ensure that the reaction proceeds under suitable temperature conditions, and is conducive to improving the stability and consistency of product quality. The electric control buttons can conveniently control the switch and emergency stop of the machine body. In case of abnormal situations in the equipment, emergency braking measures can be quickly taken to ensure the safety of the equipment and the operators, and improve the convenience and safety of equipment operation.

[0047] Through the universal wheels provided at the four corners of the bottom plate of the machine body, the equipment is convenient to move, and its position can be flexibly adjusted according to production requirements to adapt to different working sites and layouts, improving the flexibility of equipment use. The heat dissipation fans provided on the side of the machine body can timely dissipate the heat generated during the operation of the equipment, prevent the equipment from being affected in performance or damaged due to overheating, extend the service life of the equipment, ensure that the equipment can operate stably for a long time, and provide strong support for continuous production.

[0048] From the perspective of the preparation method of the skin antipruritic agent, the pretreatment steps of the raw materials are scientific and reasonable. Fresh sesame flowers are rapidly frozen and purified by gradient alcohol, maximizing the retention of active ingredients; the alcohol soaking of raw materials such as honeysuckle and the low-temperature water extraction treatment of raw materials such as cortex dictamni are all conducive to extracting key active substances. During the mixing process, through the precise control of the equipment and a unique mixing method, the raw materials can fully react and fuse, and the prepared skin antipruritic agent can better play the role of reducing irritation, inhibiting inflammation, and calming the skin, effectively relieving skin itching symptoms and providing a better treatment product for skin itching patients. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 It is a schematic diagram of the overall structure of the present invention.

[0050] Figure 2 of the present invention Figure 1 Schematic diagram of the partial structure.

[0051] Figure 3 It is a schematic diagram of the internal structure of the mixing kettle of the present invention.

[0052] Figure 4 It is a schematic diagram of the structure of the charging bucket of the present invention.

[0053] Figure 5 of the present invention Figure 4 Schematic diagram of the partial structure.

[0054] In the figure: 1, universal wheel; 2, bottom plate; 3, radiator fan; 4, machine body; 5, mixing kettle; 6, electric control button; 7, electric control box; 8, display screen; 9, feed pipe; 10, conveying pipe; 11, transfer pipe; 12, reaction tank; 13, fixing hoop; 14, discharge pipe; 15, rotating shaft; 16, belt; 17, gear; 18, motor; 19, top cover; 20, fixing ring; 21, central pipe; 22, charging bucket; 23, fixing plate; 24, movable plate; 25, clamping block. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0055] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0056] The present invention provides a preparation method and preparation equipment of a skin antipruritic agent as Figures 1-5 shown, including a machine body 4 and a bottom plate 2 provided at the bottom of the machine body 4;

[0057] Four universal wheels 4 are respectively arranged at the four corners of the bottom of the bottom plate 2. A heat dissipation fan 3 and an electric control box 7 are arranged on the side of the machine body 4. A plurality of electric control buttons 6 and a display screen 8 are arranged on the electric control box 7. A feed pipe 9 is arranged on the top of the machine body 4. A material conveying pipe 10 is arranged below the feed pipe 9. A reaction tank 12 is arranged below the material conveying pipe 10. A transmission pipe 11 is arranged on the side of the reaction tank 12. The other end of the transmission pipe 11 is provided with a mixing kettle 5. A fixing hoop 13 is arranged outside the mixing kettle 5;

[0058] A top cover 19 is arranged on the top of the mixing kettle 5. A discharge pipe 14 is arranged on the top cover 19. A central pipe 21 is arranged in the middle of the mixing kettle 5. A charging bucket 22 is arranged outside the central pipe 21. Fixing rings 20 are respectively arranged at the top and bottom of the central pipe 21. Fixing plates 23 are respectively arranged on both sides of the fixing ring 20. A rotating shaft 15 is arranged at the bottom of the central pipe 21. A gear 17 is arranged at the bottom of the rotating shaft 15. A motor 18 is arranged on the front of the machine body 4. The motor 18 is externally connected to a power supply for power supply.

[0059] In this embodiment, the skin antipruritic agent is a drug or product for relieving skin itching symptoms, which mainly plays a role by reducing irritation, inhibiting inflammation or sedating the skin. The preparation equipment of the skin antipruritic agent refers to the machinery and tools for producing antipruritic products of various dosage forms. The equipment ensures that the product meets high-quality standards during the preparation process and meets the requirements of safety and effectiveness. The specific preparation materials of this antipruritic agent are as follows: 80 - 160 g of fresh sesame flowers, 8 - 16 g of cortex dictamni, 6 - 15 g of pomegranate peel, 5 - 15 g of cloves, 5 - 15 g of nutmeg, 5 - 15 g of tsaoko, 5 - 10 g of borneol, 6 - 15 g of honeysuckle, 5 - 10 g of tsaoko fruit, 8 - 16 g of astragalus membranaceus. The specific production process of this antipruritic agent is as follows:

[0060] Step 1: Raw material pretreatment

[0061] Treatment of fresh sesame flowers:

[0062] Take 80 - 160 g of fresh sesame flowers and quickly place them in a low-temperature environment for rapid freezing. The freezing temperature is controlled at -20°C to -30°C, and the freezing time is 1 - 2 hours to retain its active ingredients to the greatest extent;

[0063] Put the frozen fresh sesame flowers into a gradient alcohol purification device, and use alcohol with a concentration gradually increasing from 30% to 70% for gradient purification. The soaking time for each purification is 2 - 3 hours. Finally, through conventional purification processes such as filtration and distillation, retain the extract;

[0064] Treatment of honeysuckle, cloves and nutmeg:

[0065] Weigh 6 - 15 g of honeysuckle, 5 - 15 g of cloves and 5 - 15 g of nutmeg respectively, and put them together into a clean and well-sealed container;

[0066] Pour sufficient 70% alcohol into the container to ensure that the raw materials are completely immersed, and soak for 24 - 36 hours. During this period, gently shake the container every 4 - 6 hours to make the soaking more uniform;

[0067] After the soaking is completed, remove the alcohol through a filtering device, and collect and retain the leachate;

[0068] Treatment of Dictamnus dasycarpus Turcz., Punica granatum L., Tsaoko fruit, Amomum tsao-ko Crevost & Lemarie, Astragalus membranaceus (Fisch.) Bunge:

[0069] Accurately weigh each raw material according to the amounts of 8 - 16 g of Dictamnus dasycarpus Turcz., 6 - 15 g of Punica granatum L., 5 - 10 g of Tsaoko fruit, 5 - 15 g of Amomum tsao-ko Crevost & Lemarie, and 8 - 16 g of Astragalus membranaceus (Fisch.) Bunge;

[0070] Put the above raw materials into a container filled with an appropriate amount of low-temperature water, and soak for 12 - 24 hours. During this period, stirring is also required at appropriate times;

[0071] After the soaking is completed, use a filtering device to separate the extract;

[0072] Step Two: Mixing of Raw Materials

[0073] Equipment Preparation:

[0074] Check whether each component of the skin antipruritic agent preparation equipment is normal, ensure that the universal wheels can rotate flexibly, the cooling fan is running normally, the electric control buttons and the display screen on the electric control box are in good function, and the motor can be normally externally powered and started;

[0075] Open the top cover of the mixing kettle, load the pretreated solid raw materials into the charging barrel through the movable plate, and close the movable plate after loading to ensure sealing;

[0076] Addition of Liquid Raw Materials:

[0077] Mix the leachates of Lonicera japonica Thunb., Syzygium aromaticum (L.) Merr. & Perry, and Myristica fragrans Houtt. obtained after alcohol soaking treatment and the extracts of Dictamnus dasycarpus Turcz., Punica granatum L., Tsaoko fruit, Amomum tsao-ko Crevost & Lemarie, and Astragalus membranaceus (Fisch.) Bunge leached with low-temperature water in proportion with an appropriate amount of paste, water, or other selected solvents in the reaction tank for preliminary mixing. During the mixing process, the temperature of the reaction tank can be controlled by the electric control box to be maintained at 30°C - 40°C, and stir for 10 - 15 minutes through the stirring device in the reaction tank to ensure uniform mixing;

[0078] Open the valve on the transfer pipe, and make the mixed liquid raw materials in the reaction tank flow into the bottom of the mixing kettle through the transfer pipe. Since the outer wall of the central pipe is a porous and hollow structure, the liquid raw materials will pass through the holes and enter the charging barrel to come into full contact with the solid raw materials;

[0079] Step Three: Mixing and Stirring

[0080] Start the motor. The motor drives the gear on it to rotate through the output shaft. The gear is driven by a belt to drive the rotating shaft to rotate, and then drives the central tube and the charging bucket to rotate synchronously;

[0081] The rotation of the charging bucket enables the solid raw materials and liquid raw materials inside to be fully mixed during continuous tumbling. The stirring time is set to 30 - 60 minutes. During this period, the temperature inside the mixing kettle can be monitored through the electric control box and the display screen. If the temperature is too high, the cooling fan will automatically start to cool down to ensure that the mixing process is carried out under suitable temperature conditions to improve the reaction efficiency of the solid raw materials and liquid raw materials;

[0082] Step 4: Discharge of the finished product

[0083] After mixing is completed, turn off the motor to stop stirring;

[0084] Open the valve of the discharge pipe on the top cover of the mixing kettle, and discharge the prepared finished skin antipruritic agent through the discharge pipe and collect it into a pre-prepared clean and sealed container;

[0085] Clean the equipment. Open the top cover of the mixing kettle, take out the residual raw materials in the charging bucket, and rinse the reaction tank, mixing kettle, and central tube components with clean water to ensure that the equipment is clean and ready for the next preparation.

[0086] As Figure 2 、 Figure 3 、 Figure 4 and Figure 5 shown, the motor 18 is fixedly installed with the machine body 4 by screws. A gear 17 is also provided on the motor 18, and the gear 17 is fixedly connected to the output shaft of the motor 18. The rotating shaft 15 is welded to the gear 17. A belt 16 is provided between the two gears 17, and the gear 17 can be driven through the belt 16. The central tube 21 is welded to the rotating shaft 15. The outer wall of the central tube 21 is a porous hollow structure. The charging bucket 22 is welded to the central tube 21. A movable plate 24 is provided at the top of the charging bucket 22, and the movable plate 24 is movably connected to the charging bucket 22 through a hinge. Solid raw materials can be loaded into the charging bucket 22 through the movable plate 24. The fixing ring 20 is sleeved on the central tube 21. A clamping block 25 is provided inside the fixing ring 20, and the clamping block 25 can be engaged with the card slot on the central tube 21. The central tube 21 can rotate on the two fixing rings 20. The fixing plate 23 is welded to the fixing ring 20, and the fixing plate 23 is welded to the mixing kettle 5. The fixing plate 23 can support the fixing ring 20 and the central tube 21. The discharge pipe 14 passes through the top cover 19 and communicates with the mixing kettle 5. The transmission pipe 11 is welded to the mixing kettle 5, and the substances inside the reaction tank 12 can flow to the mixing kettle 5 through the transmission pipe 11. The electric control box 7 can control the reaction temperature of the reaction tank 12 and the mixing kettle 5, the display screen 8 can display the temperature, and the electric control button 6 can control the switch and emergency stop of the machine body 4.

[0087] Preferably, through the settings of the transfer pipe 11, the mixing kettle 5, the central pipe 21, the charging bucket 22 and the movable plate 24, opening the movable plate 24 allows solid raw materials to be loaded into the charging bucket 22. The liquid raw materials can enter from the bottom of the mixing kettle 5 through the transfer pipe 11. Since there are holes on the outer wall of the central pipe 21, the liquid raw materials can enter the charging bucket 22 through the holes and come into contact with the solid raw materials inside the charging bucket 22, making the fixed raw materials immersed in the liquid raw materials. And due to this solid-liquid separation design, the work of separating and cleaning the solid and liquid in the mixing kettle is more convenient and fast.

[0088] Preferably, through the settings of the gear 17, the belt 16, the motor 18 and the rotating shaft 15, starting the motor 18 can drive the gear 17 to rotate. Through the cooperation of the gear 17 and the belt 16, the rotating shaft 15 can be further driven to rotate, and then the central pipe 21 and the charging bucket 22 can be rotated. Through the rotation of the charging bucket 22, the solid raw materials and the liquid raw materials inside can be fully mixed, improving the reaction efficiency of the solid raw materials and the liquid raw materials. Through the settings of the fixing plate 23, the fixing ring 20 and the clamping block 25, the fixing ring 20 is fixed inside the mixing kettle 5 through the fixing plates 23 on both sides. The fixing ring 20 can keep the central pipe 21 stable during the rotation process.

[0089] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. A device for preparing a skin antipruritic agent, comprising a body (4) and a bottom plate (2) arranged at the bottom of the body (4); Universal wheels (4) are respectively arranged at the four corners of the bottom of the base plate (2); a cooling fan (3) and an electric control box (7) are arranged on the side of the machine body (4); a plurality of electric control buttons (6) and a display screen (8) are arranged on the electric control box (7); a feed pipe (9) is arranged on the top of the machine body (4); a delivery pipe (10) is arranged below the feed pipe (9); a reaction tank (12) is arranged below the delivery pipe (10); a transmission pipe (11) is arranged on the side of the reaction tank (12); a mixing kettle (5) is arranged at the other end of the transmission pipe (11); a fixing hoop (13) is arranged on the outside of the mixing kettle (5); Features: The top of the mixing kettle (5) is provided with a top cover (19), and a discharge pipe (14) is provided on the top cover (19). A central tube (21) is provided in the middle of the mixing kettle (5), and a charging bucket (22) is provided on the outer side of the central tube (21). A fixing ring (20) is provided on the top and bottom of the central tube (21), and fixing plates (23) are provided on both sides of the fixing ring (20). A rotating shaft (15) is provided at the bottom of the central tube (21), and a gear (17) is provided at the bottom of the rotating shaft (15). A motor (18) is provided on the front of the machine body (4), and the motor (18) is powered by an external power supply.

2. The preparation device of a skin antipruritic agent according to claim 1, characterized in that: The motor (18) is fixedly mounted on the machine body (4) by means of screws. A gear (17) is also provided on the motor (18), and the gear (17) is fixedly connected to the output shaft of the motor (18).

3. The preparation device of a skin antipruritic agent according to claim 2, characterized in that: The rotating shaft (15) is welded to the gear (17), a belt (16) is arranged between the two gears (17), and the gears (17) can be driven by the belt (16).

4. The preparation device of a skin antipruritic agent according to claim 3, characterized in that: The central tube (21) is welded to the rotating shaft (15); the outer wall of the central tube (21) is a porous hollow structure; the charging barrel (22) is welded to the central tube (21); a movable plate (24) is provided on the top of the charging barrel (22); the movable plate (24) is movably connected to the charging barrel (22) via a hinge; and solid raw materials can be loaded into the charging barrel (22) via the movable plate (24).

5. The preparation device of a skin antipruritic agent according to claim 4, characterized in that: The fixing ring (20) is sleeved with the center tube (21), a clamping block (25) is arranged inside the fixing ring (20), the clamping block (25) can be mutually clamped with a clamping groove on the center tube (21), and the center tube (21) can rotate on the two fixing rings (20).

6. The preparation device of a skin antipruritic agent according to claim 5, characterized in that: The fixing plate (23) is welded to the fixing ring (20), and the fixing plate (23) is welded to the mixing kettle (5). The fixing plate (23) can support the fixing ring (20) and the central tube (21).

7. The preparation device of a skin antipruritic agent according to claim 6, characterized in that: The discharge pipe (14) passes through the top cover (19) and is connected to the mixing kettle (5). The transmission pipe (11) is welded to the mixing kettle (5). The material inside the reaction tank (12) can flow to the mixing kettle (5) through the transmission pipe (11).

8. The preparation device of a skin antipruritic agent according to claim 1, characterized in that: The electric control box (7) can control the reaction temperature of the reaction tank (12) and the mixing kettle (5), the display screen (8) can display the temperature, and the electric control button (6) can control the switch and emergency stop of the machine body (4).

9. A method for preparing a skin antipruritic agent according to any one of claims 1 to 8, characterized in that: The preparation method steps are as follows: Step 1: Raw material pretreatment Fresh sesame flower processing: Take 80-160g of fresh sesame flowers, and quickly freeze them in a low temperature environment. The freezing temperature is controlled at -20℃ to -30℃, and the freezing time is 1-2 hours to retain the effective ingredients to the greatest extent; The frozen fresh sesame flowers are placed in a gradient alcohol purification device, and are purified by gradient alcohol with concentrations gradually increasing from 30% to 70%. Each purification soaking time is 2-3 hours. Finally, conventional purification processes such as filtration and distillation are performed to retain the extracts. Honeysuckle, cloves, nutmeg treatment: Weigh 6-15g of honeysuckle, 5-15g of cloves, and 5-15g of nutmeg respectively, and put them together in a clean and well-sealed container; Pour enough 70% alcohol into the container to ensure that the raw materials are completely immersed. The soaking time lasts for 24-36 hours. During this period, gently shake the container every 4-6 hours to ensure a more even soaking. After the soaking is finished, the alcohol is removed by filtering device, and the extract is collected and retained; Treatment with white moss peel, pomegranate peel, tsaoko, tsaoko, and astragalus: Accurately weigh the raw materials according to the amount of 8-16g of white moss peel, 6-15g of pomegranate peel, 5-10g of tsaoko, 5-15g of tsaoko, and 8-16g of astragalus; Put the above ingredients into a container with an appropriate amount of low-temperature water and soak for 12-24 hours, stirring them from time to time; After the soaking is completed, the extract is separated using a filtering device; Step 2: Mixing the raw materials Equipment preparation: Check whether all parts of the skin antipruritic preparation equipment are normal, ensure that the universal wheels can rotate flexibly, the cooling fan operates normally, the electric control buttons and display screen on the electric control box are in good function, and the motor can be normally connected to the external power supply and started; Open the top cover of the mixing kettle, and load the pre-treated solid raw materials into the loading barrel through the movable plate. After the loading is completed, close the movable plate to ensure sealing; Liquid raw material addition: The extracts of honeysuckle, cloves and nutmeg obtained after alcohol soaking and the extracts of white moss peel, pomegranate peel, tsaoko, tsaoko and astragalus root extracted with low-temperature water are preliminarily mixed with appropriate amounts of ointment, water or other selected solvents in a reaction tank in proportion. During the mixing process, the temperature of the reaction tank can be controlled by an electric control box to be maintained at 30°C-40°C, and stirred for 10-15 minutes by a stirring device in the reaction tank to ensure uniform mixing; Open the valve on the transmission pipe to allow the mixed liquid raw materials in the reaction tank to flow into the bottom of the mixing kettle through the transmission pipe. Since the outer wall of the central tube is a porous hollow structure, the liquid raw materials will pass through the holes into the charging barrel and fully contact with the solid raw materials. Step 3: Mix and stir Start the motor, the motor drives the gear on it to rotate through the output shaft, the gear drives the shaft to rotate through the belt, and then drives the center tube and the loading barrel to rotate synchronously; The rotation of the charging barrel allows the solid raw materials and liquid raw materials inside to be fully mixed in continuous tumbling. The stirring time is set to 30-60 minutes. During this period, the temperature in the mixing kettle can be monitored through the electric control box and the display screen. If the temperature is too high, the cooling fan will automatically start to cool it down to ensure that the mixing process is carried out under appropriate temperature conditions to improve the reaction efficiency of solid raw materials and liquid raw materials. Step 4: Finished product discharge After the mixing is completed, turn off the motor and stop stirring; Open the discharge pipe valve on the top cover of the mixing kettle, release the prepared skin antipruritic agent through the discharge pipe, and collect it in a clean, sealed container prepared in advance; Clean the equipment, open the top cover of the mixing kettle, take out the remaining raw materials in the charging barrel, and rinse the reaction tank, mixing kettle, and central tube components with clean water to ensure that the equipment is clean and ready for the next preparation.

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