Sample analysis system

Abstract

According to the sample analysis system and the sample analysis method provided by the embodiment of the invention, on one hand, the interferent information in the to-be-detected sample can be obtained according to the photoelectric data of the to-be-detected sample or the mixed solution of the to-be-detected sample, and on the other hand, the interferent information of the reaction solution can be obtained according to the photoelectric data of the reaction solution of the to-be-detected sample; the interferent type or the interferent source of the reaction liquid is judged by combining the interferent information in the two aspects, and compared with an interference determination mode of manually checking the sample state, the technical scheme of each embodiment of the invention can eliminate the influence of subjective factors, and the information for judging interference is more diversified and comprehensive; therefore, a more reliable basis is provided for interference elimination, and the accuracy of a sample detection result can be improved.

Description

[0001] This application claims the priority of Chinese patent applications filed with the China National Intellectual Property Administration on September 29, 2024, with application number 202411371179.1 and invention title "Sample Analysis System", and on December 27, 2023, with application number 202311834875.7 and invention title "Sample Analysis System, Sample Analysis Method", the entire contents of which are incorporated herein by reference. Technical Field

[0002] This application relates to the technical field of medical devices, and more specifically, to a sample analysis system and a sample analysis method. Background Art

[0003] A sample analysis system such as a biochemical analyzer is an instrument used to analyze and measure samples. Generally, reagents are added to the samples, and the samples after reacting with the reagents are measured in a certain way to obtain the test results of the samples under various test items. If there is interference during the test process, the accuracy of the test results will be reduced. Therefore, a method is needed to accurately identify the interference existing in the sample detection process. Summary of the Invention

[0004] In view of this, this application provides a sample analysis system and a sample analysis method to determine the information of interfering substances existing in the sample detection process, provide a basis for interference elimination, and thus improve the accuracy of sample test results.

[0005] In a first aspect, an embodiment of this application provides a sample analysis system, including:

[0006] A sample dispensing mechanism for dispensing a sample to be tested in a sample tube into a reaction vessel;

[0007] A reagent dispensing mechanism for dispensing a reaction reagent into the reaction vessel;

[0008] A reaction device provided with at least one reaction position for placing the reaction vessel, and a reaction solution is prepared from the sample to be tested and the reaction reagent in the reaction vessel;

[0009] A detection device including a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms outgoing light after passing through the reaction vessel, and the optical signal detector collects the outgoing light to obtain optoelectronic data;

[0010] A control device configured to control the sample analysis system to perform interference detection on the test sample or a mixture of the test sample to obtain first interference information, where the mixture is prepared from the test sample and a pretreatment solution; obtain second interference information based on the optoelectronic data of the reaction solution; and determine the type or source of interference of the reaction solution based on the first interference information and the second interference information.

[0011] In a second aspect, an embodiment of the present application provides a sample analysis system, including:

[0012] A sample dispensing mechanism for dispensing the test sample in the sample tube into a reaction vessel;

[0013] A reagent dispensing mechanism for dispensing a reaction reagent into the reaction vessel;

[0014] A reaction device provided with at least one reaction site for placing the reaction vessel, where the test sample and the reaction reagent in the reaction vessel are used to prepare a reaction solution;

[0015] A detection device including a light source assembly and an optical signal detector; during the project detection process: the light source assembly is used to generate irradiation light, the irradiation light forms outgoing light after passing through the reaction vessel, and the optical signal detector collects the outgoing light to obtain optoelectronic data;

[0016] A control device configured to control the sample analysis system to perform interference detection on the test sample or a mixture of the test sample to obtain first interference information, where the mixture is prepared from the test sample and a pretreatment solution; obtain second interference information based on the optoelectronic data of the reaction solution; and correct the optoelectronic data based on the first interference information and the second interference information to obtain the detection result of the detection item.

[0017] In a third aspect, an embodiment of the present application provides a sample analysis system, including:

[0018] A sample dispensing mechanism for dispensing the test sample in the sample tube into a reaction vessel;

[0019] A reagent dispensing mechanism for dispensing a reaction reagent into the reaction vessel;

[0020] A reaction device provided with at least one reaction site for placing the reaction vessel, where the test sample and the reaction reagent in the reaction vessel are used to prepare a reaction solution;

[0021] Detection device, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms outgoing light after passing through the reaction vessel, and the optical signal detector collects the outgoing light to obtain optoelectronic data;

[0022] Control device, configured to:

[0023] When it is determined that there are interfering substances in the test sample or the mixture of the test sample based on the test sample or the mixture of the test sample, control the sample analysis system to process the test sample to remove the interfering substances in the test sample;

[0024] Control the sample dispensing mechanism to dispense the processed test sample into the reaction vessel;

[0025] Obtain the test result of the item according to the optoelectronic data of the reaction solution.

[0026] In a fourth aspect, an embodiment of the present application provides a sample analysis system, including:

[0027] A sample dispensing mechanism for dispensing a test sample in a sample tube into a reaction vessel;

[0028] A reagent dispensing mechanism for dispensing a reaction reagent into the reaction vessel;

[0029] A reaction device, the reaction device is provided with at least one reaction position, the reaction position is used to place the reaction vessel, and the test sample in the reaction vessel and the reaction reagent are prepared to obtain a reaction solution;

[0030] Detection device, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms outgoing light after passing through the reaction vessel, and the optical signal detector collects the outgoing light to obtain optoelectronic data;

[0031] An acquisition device for obtaining first interfering substance information of the test sample or the mixture of the test sample, the mixture is prepared from the test sample and a pretreatment solution;

[0032] The control device is configured to obtain second interfering substance information according to the optoelectronic data of the reaction solution; determine the type or source of the interfering substance in the reaction solution according to the first interfering substance information and the second interfering substance information.

[0033] In a fifth aspect, an embodiment of the present application provides a sample analysis system, including:

[0034] A sample preparation device, the sample preparation device is used to prepare a reaction solution by using at least part of the test sample and a reaction reagent;

[0035] Detection device, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms a first outgoing light after irradiating a pretreatment solution or at least part of the sample to be tested, the optical signal detector collects the first outgoing light to obtain first optoelectronic data, the irradiation light forms a second outgoing light after irradiating the reaction solution, the optical signal detector collects the second outgoing light to obtain second optoelectronic data; wherein, the pretreatment solution is prepared by the sample preparation device using at least part of the sample to be tested and a pretreatment reagent;

[0036] Control device, configured to obtain first interferent information in the sample to be tested according to the first optoelectronic data; obtain second interferent information in the reaction solution and the detection result of the detection item of the sample to be tested according to the second optoelectronic data; jointly determine the type or source of the interferent in the reaction solution according to the first interferent information and the second interferent information.

[0037] In a sixth aspect, an embodiment of the present application provides a sample analysis system, including:

[0038] Sample preparation device, the sample preparation device is used to prepare a reaction solution by using at least part of the sample to be tested and a reaction reagent;

[0039] Detection device, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms a first outgoing light after irradiating a pretreatment solution or at least part of the sample to be tested, the optical signal detector collects the first outgoing light to obtain first optoelectronic data, the irradiation light forms a second outgoing light after irradiating the reaction solution, the optical signal detector collects the second outgoing light to obtain second optoelectronic data; wherein, the pretreatment solution is prepared by the sample preparation device using at least part of the sample to be tested and a pretreatment reagent;

[0040] Control device, configured to obtain first interferent information in the sample to be tested according to the first optoelectronic data; obtain second interferent information in the reaction solution according to the second optoelectronic data; correct the second optoelectronic data according to the first interferent information and the second interferent information, and obtain the detection result of the detection item of the sample to be tested based on the corrected second optoelectronic data.

[0041] In a seventh aspect, an embodiment of the present application provides a sample analysis system, including:

[0042] Sample preparation device, the sample preparation device is used to prepare a reaction solution by using at least part of the sample to be tested and a reaction reagent;

[0043] Detection device, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms outgoing light after irradiating the reaction solution, and the optical signal detector collects the outgoing light to obtain optoelectronic data;

[0044] Obtaining device, configured to obtain first interferent information of the sample to be tested or the pretreatment solution, where the pretreatment solution is prepared by the sample preparation device using at least part of the sample to be tested and a pretreatment reagent;

[0045] Control device, configured to obtain second interferent information in the reaction solution according to the optoelectronic data, and jointly determine the type or source of the interferent in the reaction solution according to the first interferent information and the second interferent information.

[0046] In an eighth aspect, an embodiment of the present application provides a sample analysis system, including:

[0047] Sample preparation device, the sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent;

[0048] Detection device, detecting the pretreatment solution or the sample to be tested to obtain a first detection parameter, and detecting the reaction solution to obtain a second detection parameter, where the pretreatment solution is prepared by the sample preparation device using at least part of the sample to be tested and a pretreatment reagent;

[0049] Control device, configured to obtain first interferent information in the sample to be tested according to the first detection parameter; obtain second interferent information in the reaction solution according to the second detection parameter; determine the type or source of the interferent in the reaction solution according to the first interferent information and the second interferent information.

[0050] In a ninth aspect, an embodiment of the present application provides a sample analysis method, including:

[0051] Obtaining the sample to be tested or a mixed solution of the sample to be tested for interferent detection to obtain first interferent information, where the mixed solution is prepared by the sample to be tested and a pretreatment solution;

[0052] Obtaining optoelectronic data of a reaction solution prepared by the sample to be tested and a reaction reagent, and obtaining second interferent information according to the optoelectronic data of the reaction solution, where the optoelectronic data is obtained by collecting the outgoing light of the irradiation light of the reaction solution by a light source;

[0053] Determining the type or source of the interferent in the reaction solution according to the first interferent information and the second interferent information; or, correcting the optoelectronic data according to the first interferent information and the second interferent information to obtain a detection result of a detection item.

[0054] In a tenth aspect, an embodiment of the present application provides a sample analysis method, including:

[0055] Performing interference detection on a sample to be tested or a mixture of the sample to be tested, where the mixture is prepared from the sample to be tested and a pretreatment solution;

[0056] In the case where the interference detection indicates that there are interfering substances in the sample to be tested, processing the sample to be tested to remove the interfering substances in the sample to be tested;

[0057] Preparing a reaction solution by mixing the processed sample to be tested with a reagent, and collecting optoelectronic data of the reaction solution, where the optoelectronic data is obtained by irradiating the outgoing light of the reaction solution with a light source during the detection process of a collection item;

[0058] Determining a detection result of an item based on the optoelectronic data of the reaction solution.

[0059] Based on the above technical solutions, in the sample analysis system and sample analysis method provided by the embodiments of the present application, on the one hand, interfering substance information in the sample to be tested can be obtained according to the optoelectronic data of the sample to be tested or the mixture of the sample to be tested, and on the other hand, interfering substance information of the reaction solution can also be obtained according to the optoelectronic data of the reaction solution of the sample to be tested. By comprehensively considering the interfering substance information from both aspects, the type or source of the interfering substances in the reaction solution can be determined. Compared with the method of manually checking the sample status to determine interference, the technical solutions of the embodiments of the present application can eliminate the influence of subjective factors and the information used to judge interference is more diverse and comprehensive, thereby providing a more reliable basis for interference elimination and improving the accuracy of sample detection results. Description of the Drawings

[0060] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present invention, and those of ordinary skill in the art can obtain other drawings based on these drawings without creative efforts.

[0061] Figure 1 It is a schematic structural diagram of a sample analysis system provided by an embodiment of the present application;

[0062] Figure 2A - 2B It is two example diagrams of the optical signal pulse waveforms provided by an embodiment of the present application;

[0063] Figure 3A - 3B It is two process schematic diagrams of a sample interference analysis method provided by an embodiment of the present application;

[0064] Figure 4AA three-dimensional spectrum example diagram of the creatinine item provided by the embodiment of the present application with globulin interference;

[0065] Figure 4B A three-dimensional spectrum example diagram of the creatinine item provided by the embodiment of the present application with lipemia interference;

[0066] Figure 5 A schematic flow diagram of a sample interference analysis method provided by the embodiment of the present application;

[0067] Figure 6A A spectrum example diagram of the CK item without interference provided by the embodiment of the present application;

[0068] Figure 6B A spectrum example diagram of the CK item under lipemia interference provided by the embodiment of the present application;

[0069] Figure 7 An example diagram of interference prompt information provided by the embodiment of the application;

[0070] Figure 8A - 8B Two schematic flow diagrams of retesting the sample provided by the embodiment of the present application;

[0071] Figure 9 A schematic flow diagram of a sample interference analysis method provided by the embodiment of the present application;

[0072] Figure 10 A schematic flow diagram of a sample interference analysis method provided by the embodiment of the present application. Detailed implementation manners

[0073] In the clinical detection of samples, there are often interferences in the samples themselves or the reaction process, which affect the accuracy of the detection items. Interferences may come from various aspects, including but not limited to: high-concentration environmental CO2 changing the alkaline environment of the reaction, physical collision during blood collection causing physical hemolysis, and non-standard blood collection by patients resulting in lipemia, etc. Currently, the method of manually observing samples is usually used to exclude interferences, but this interference exclusion method is affected by subjective factors or due to single-factor judgment, resulting in inaccurate determination of interferences. If the interference substance information cannot be determined, corresponding treatment measures cannot be taken to exclude interferences, but improper abnormal treatment methods not only cannot eliminate interferences but may also cause reagent waste, affect the sample detection throughput and overall efficiency, etc.

[0074] The embodiment of the present application provides a sample analysis system, which comprehensively uses the optoelectronic data of the sample to be tested (or the pretreatment solution of the sample to be tested) and the optoelectronic data of the reaction solution prepared from the sample to be tested to determine the interference substance information, providing an accurate basis for interference exclusion.

[0075] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present application without creative efforts shall fall within the protection scope of the present application.

[0076] Specifically, the embodiment of the present application provides a sample analysis system, including: a sample preparation device, a detection device, and a control device.

[0077] The sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent; and is used to prepare a pretreatment solution of the sample to be tested using at least part of the sample to be tested and a pretreatment reagent. A structure of the sample preparation device can be seen Figure 1 as shown, including a sample dispensing mechanism 10, a reagent dispensing mechanism 20, and a reaction device 30.

[0078] The detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, and the irradiation light forms a first emitted light after irradiating the pretreatment solution or at least part of the sample to be tested. The optical signal detector collects the first emitted light to obtain first optoelectronic data. The irradiation light forms a second emitted light after irradiating the reaction solution, and the optical signal detector collects the second emitted light to obtain second optoelectronic data. It can be seen that the detection device can obtain the optoelectronic data of the sample to be tested (or the pretreatment solution of the sample to be tested) using an optical detection method. For the convenience of distinction, this optoelectronic data is called first optoelectronic data; the detection device can also obtain the optoelectronic data of the reaction solution using an optical detection method. For the convenience of distinction, this optoelectronic data is called second optoelectronic data.

[0079] The control device is configured to obtain interference information in the sample to be tested based on the first optoelectronic data (for the convenience of distinction, the interference information in the sample to be tested can be called first interference information); obtain interference information in the reaction solution and the detection result of the detection item of the sample to be tested based on the second optoelectronic data (for the convenience of distinction, the interference information in the reaction solution can be called second interference information); jointly determine the type or source of interference in the reaction solution based on the first interference information and the second interference information.

[0080] It should be noted that the second optoelectronic data can be used on the one hand to obtain the interference information in the reaction solution, and on the other hand to obtain the detection result of the detection item of the sample to be tested. Among them, in a specific implementation manner, to ensure the accuracy of the detection result of the detection item, the second optoelectronic data can be combined with the type or source of interference to comprehensively determine the detection result of the detection item.

[0081] Since the test results of the test items are obtained based on the optoelectronic data of the reaction solution, but the optoelectronic data is sensitive to some interferences in the reaction solution. For example, abnormalities in the physical properties of the reaction solution such as color, floccules, lumps, precipitation, etc. will cause the optoelectronic data of the reaction solution to be inaccurate, and thus the test results obtained based on the optoelectronic data of the reaction solution are also inaccurate. Therefore, in order to more accurately determine the interference in the reaction solution, the embodiments of the present application comprehensively determine the type or source of the interfering substance in the reaction solution according to the two aspects of interfering substance information, namely the first interfering substance information and the second interfering substance information. This method can be called joint judgment. Compared with the method of only using the second interfering substance information to determine the type or source of the interfering substance in the reaction solution, the information sources used to judge interference are richer in this joint judgment method, and the judgment results of interference are more accurate. It can be understood that the joint judgment method in the embodiments of the present application does not obtain the type or source of the interfering substance in the reaction solution by only using the first interfering substance information or only using the second interfering substance information, but combines these two types of interfering substance information, namely the first interfering substance information and the second interfering substance information, to obtain the type or source of the interfering substance. In addition, from the perspective of the type or source of the interfering substance, it is the comprehensive judgment result of these two types of interfering substance information, namely the first interfering substance information and the second interfering substance information, rather than being obtained only from one of the interfering substance information types.

[0082] The joint judgment can include multiple implementation methods. For example, a specific method is to compare the first interfering substance information with the second interfering substance information, and determine the type or source of the interfering substance in the reaction solution according to the comparison result. Among them, the first interfering substance information is used to reflect the interference related to the sample to be tested, and the second interfering substance information is used to reflect the interference related to the reaction solution. By comparing the first interfering substance information and the second interfering substance information, the differences or similarities between the interferences reflected by the two types of interfering substance information can be found, so as to determine the source or type of the interfering substance.

[0083] In a specific comparison method, the first interfering substance information and the second interfering substance information are signal waveforms (referred to as the first signal waveform and the second signal waveform respectively), and the source of the interfering substance can be determined by comparing the differences between the first signal waveform and the second signal waveform. Specifically, if the first signal waveform is an abnormal signal waveform and the second signal waveform is an abnormal signal waveform, it indicates that the interfering substance is probably from the sample to be tested; if the first signal waveform is a normal signal waveform and the second signal waveform is an abnormal signal waveform, it indicates that the interfering substance is probably from the reaction reagent added to the sample to be tested or from the reaction process; if the first signal waveform is an abnormal signal waveform and the second signal waveform is a normal signal waveform, it indicates that the detection is abnormal or the interfering substance is probably from the sample to be tested; if the first signal waveform is a normal signal waveform and the second signal waveform is a normal signal waveform, it indicates that there is no interfering substance.

[0084] In another specific comparison method, the first interferent information and the second interferent information are the interferent contents (referred to as the first interferent content and the second interferent content respectively), and the interferent type can be determined by comparing the difference between the first interferent content and the second interferent content. For example, if the first interferent content indicates that the lipemic interference content is 10, and the second interferent content indicates that the overall lipemic interference content and the globulin interference content is 100, then by combining the first interferent content and the second interferent content, it can be determined that the globulin interference content is 90. Therefore, it can be seen that the comparison of the two types of interferent information can also be the combined calculation of the two types of interferent information. Of course, the combined calculation is not limited to subtraction, and the corresponding calculation method can be set according to the specific interferent type.

[0085] In yet another specific comparison method, the first interferent information and the second interferent information are the interferent types (referred to as the first interferent type and the second interferent type respectively), and the interferent type of the reaction solution can be determined by comparing the commonalities and differences between the first interferent type and the second interferent type. For example, the common interferent types in the first interferent type and the second interferent type are determined as the interferent type of the reaction solution; or, if the first interferent type does not include a specific interferent type and the second interferent type includes the specific interferent type, the specific interferent type is excluded from the second interferent type and the remaining second interferent type is used as the interferent type of the reaction solution.

[0086] In addition to the above comparison methods, another specific implementation of the combined judgment is to input the first interferent information and the second interferent information into a pre-trained artificial intelligence detection model, and the artificial intelligence detection model comprehensively judges by combining the first interferent information and the second interferent information to obtain the interferent type or the interferent source of the reaction solution.

[0087] See Figure 1 , which is a schematic structural diagram of a sample analysis system provided by an embodiment of the present application. The sample analysis system may include, but is not limited to, any one of the following: a biochemical analysis system, a coagulation analysis system. As Figure 1 shown, the sample analysis system includes: a sample dispensing mechanism 10, a reagent dispensing mechanism 20, a reaction device 30, a detection device 40, and a control device 50.

[0088] The sample dispensing mechanism 10 is used to dispense a part of the sample to be tested in the sample tube into the reaction container. The sample to be tested may include, but is not limited to, any one of a blood sample, a body fluid sample, and a urine sample. In one embodiment, the sample dispensing mechanism at least includes a sampling needle to aspirate the sample to be tested from the sample tube and dispense the aspirated sample to be tested into the reaction container of the reaction device. For example, Figure 1The sampling needle of the sample dispensing mechanism 10 in the middle aspirates a part of the sample to be tested from the sample tube and dispenses it into the reaction vessel 301. In one embodiment, the sampling needle of the sample dispensing mechanism 10 moves in two or three dimensions in space through a two-dimensional or three-dimensional drive mechanism to achieve: moving to aspirate a part of the sample to be tested in the sample container and moving to the reaction vessel 301 to be loaded with the sample and discharging the sample into the reaction vessel 301.

[0089] The reagent dispensing mechanism 20 is used to dispense reagents (pretreatment reagents and reaction reagents) into the reaction vessel. In one embodiment, the reagent dispensing mechanism 20 may include a reagent needle, and the reagent needle moves in two or three dimensions in space through a two-dimensional or three-dimensional drive mechanism, which can achieve: moving to aspirate the reagents carried by the reagent component and moving to the reaction vessel 301 to be loaded with the reagent, and discharging the reagent into the reaction vessel 301. In various embodiments of the present application, although the pretreatment reagent can be called a reagent, it is different from the reaction reagent. The pretreatment reagent does not produce a biochemical reaction with the sample to be tested, but only plays a role in diluting the sample to be tested and creating a reaction environment for the sample to be tested.

[0090] It should be noted that when preparing the reaction solution in various embodiments of the present application, the dispensing order of the reagent and the sample to be tested into the reaction vessel is not limited, that is: the reagent can be dispensed into the reaction vessel first and then the sample to be tested, or of course, the sample to be tested can be dispensed into the reaction vessel first and then the reagent.

[0091] The reaction device 30 is provided with at least one reaction position, and the reaction position is used to place the reaction vessel 301 carrying the reaction solution, and the reaction solution is prepared from the sample to be tested and the reagent. Reaction vessels such as reaction vessels, reaction tanks, etc. In one embodiment, the reaction device 30 can be a reaction disk, which is arranged in a disk-shaped structure and has one or more reaction positions for placing reaction vessels. The reaction disk can rotate and drive the reaction vessels in its reaction positions to rotate, which is used to schedule the reaction vessels in the reaction disk and incubate the reaction solution in the reaction vessels. In one embodiment, the sample analysis system further includes a mixing mechanism for mixing the reaction solution that needs to be mixed in the reaction vessel to make the substances in the reaction solution evenly distributed.

[0092] The detection device 40 includes a light source assembly 401 and an optical signal detector 402; the light source assembly 401 is used to generate irradiation light, and the irradiation light forms outgoing light after irradiating the reaction vessel 301, and the optical signal detector 402 collects the outgoing light to obtain optoelectronic data. In one embodiment, the optical signal detector 402 can be a photometer.

[0093] After the reagent in the reaction vessel 301 is mixed with the sample to be tested, a reaction solution can be prepared, and the optoelectronic data obtained in this case is the optoelectronic data of the reaction solution. It should be noted that in some embodiments, after the sample to be tested is injected into the reaction vessel 301, the reagent is not injected. In this case, the detection device 40 can collect the optoelectronic data of the sample to be tested. In other embodiments, after the reagent is injected into the reaction vessel 301, the sample to be tested is not injected. In this case, the detection device 40 can collect the optoelectronic data of the reagent.

[0094] There are various specific implementation manners for the detection device 40 to obtain optoelectronic data.

[0095] One implementation manner is to collect optoelectronic data globally. The irradiation light generated by the light source assembly 401 irradiates the same position of the reaction solution in the reaction vessel, and the emitted light formed includes at least two optical signal with different wavelengths. The optical signal detector 402 converts the optical signals of at least two wavelengths into optoelectronic data. For example, optical signals of multiple wavelengths are collected simultaneously in parallel, the detection positions and time periods of multiple wavelengths are the same, and the optoelectronic data between multiple wavelengths has reference significance. For example, the state information of the reaction solution can be obtained.

[0096] Another implementation manner is to collect optoelectronic data all the time. The reaction vessel 301 rotates around the light source assembly 401, and optoelectronic data is collected during the process that the light source assembly 401 continuously irradiates the reaction vessel 402. The optoelectronic data includes a signal sequence formed by the relationship between the intensities of at least two optical signals with different wavelengths and the acquisition time. In some implementation manners, the signal sequence can also be called an optical signal pulse waveform. The signal sequence can be a graph including optical signal intensity and time information formed by one pulse, or a data array including the corresponding relationship between optical signal intensity and time information.

[0097] During the process that the light source assembly 401 continuously irradiates the same reaction vessel 402, optoelectronic data of wavelengths is collected in one or more detection cycles. The optoelectronic data of wavelengths includes a signal sequence of one or more detection cycles, and the signal sequence of each detection cycle includes at least two light intensity data of this wavelength. Figure 2A For example, the optoelectronic data includes signal sequences of two detection cycles, and the signal sequence of each detection cycle is the corresponding relationship between at least two light intensity signals and the acquisition time.

[0098] Another specific implementation manner is to collect optoelectronic data globally all the time, that is, the combination of the above two collection methods. Optical signals of at least two wavelengths are collected all the time to obtain optoelectronic data. In this case, the optoelectronic data obtained can include a signal sequence formed by the relationship between the intensities of optical signals of at least two wavelengths and the acquisition time.

[0099] Specifically, during the process of the light source assembly continuously irradiating the same reaction vessel, optoelectronic data for each of n wavelengths are collected in parallel during one or more detection cycles. The optoelectronic data for each wavelength includes a signal sequence for one or more detection cycles, and the signal sequence for each detection cycle includes at least two light intensity data for that wavelength. Taking Figure 2B as an example, the detection device collects full-time optoelectronic data for multiple wavelengths in two detection cycles of the reaction vessel in parallel. The optoelectronic data includes signal sequences for multiple wavelengths from wavelength 1 to wavelength n, and each signal sequence includes the correspondence between the intensities of at least two optical signals with different wavelengths and the acquisition time. It can also be considered that Figure 2B what is obtained is the pulse waveform of the optical signal for multiple wavelengths.

[0100] Another specific implementation is to use panoramic dynamic optical measurement technology (Panorama, Dynamic, Recognization, PDR) to collect optoelectronic data, that is, to dynamically collect optical signals in the whole time period, the whole wavelength band, and the whole reflection domain to obtain the optoelectronic data of the reaction solution.

[0101] For the convenience of distinguishing from the reaction vessel for accommodating the sample to be tested (or the pretreatment solution of the sample to be tested), the above reaction vessel for accommodating the reaction solution is called the second reaction vessel. In addition, for the convenience of distinguishing from the outgoing light formed after the irradiation light irradiates the sample to be tested (or the pretreatment solution of the sample to be tested), the outgoing light formed after the irradiation light irradiates the reaction solution can be called the second outgoing light.

[0102] The control device 50 is configured to control the sample analysis system to detect interfering substances in the sample to be tested or the pretreatment solution of the sample to be tested to obtain first interfering substance information; obtain second interfering substance information according to the optoelectronic data of the reaction solution; and determine the type or source of the interfering substances in the reaction solution according to the first interfering substance information and the second interfering substance information.

[0103] Specifically, the sample analysis system can detect interfering substances in the sample to be tested (or the pretreatment solution of the sample to be tested) under the control of the control device 50 to obtain interfering substance information. It should be noted that the interfering substance detection can be any detection means that can detect information related to interfering substances.

[0104] In some embodiments, an optical detection method can be used.

[0105] The sample dispensing mechanism is used to dispense a part of the sample to be tested into the reaction vessel (to distinguish from the reaction vessel for accommodating the reaction solution, the reaction vessel for accommodating the sample to be tested is called the first reaction vessel), and the reagent dispensing mechanism is used to dispense the pretreatment reagent into the first reaction vessel to form the pretreatment solution (or not dispense the pretreatment reagent into the first reaction vessel, in which case the first reaction vessel contains the sample to be tested).

[0106] The irradiation light emitted by the light source assembly 401 irradiates the sample to be tested or the pretreatment solution of the sample to be tested in the first reaction vessel, and then the outgoing light (the first outgoing light) is formed. The optical signal detector 402 collects the outgoing light and converts the outgoing light into optoelectronic data (the first optoelectronic data). Among them, the detection device 40 performs interference detection on the sample to be tested or the pretreatment solution of the sample to be tested to obtain the optoelectronic data of the sample to be tested or the pretreatment solution of the sample to be tested. For example, the detection device 40 performs serum index detection on the sample to be tested (or the pretreatment solution of the sample to be tested) to obtain the first optoelectronic data. For example, the detection device 40 performs item detection on the sample to be tested (or the pretreatment solution of the sample to be tested) to obtain the first optoelectronic data. Furthermore, the control device 50 obtains the first interference information in the sample to be tested according to the first optoelectronic data of the sample to be tested or the pretreatment solution of the sample to be tested.

[0107] The above method can be called the deceleration method for detecting the first interference information, and the first interference information can also be detected by the non-deceleration method. Specifically:

[0108] The sample dispensing mechanism 10 dispenses at least part of the sample to be tested into the reaction vessel. The reagent dispensing mechanism 20 is used to dispense the pretreatment reagent into the reaction vessel to form a pretreatment solution. At this time, the reaction vessel contains the pretreatment solution of the sample to be tested. The irradiation light emitted by the light source assembly 401 irradiates the pretreatment solution in the reaction vessel to form the first outgoing light. The optical signal detector 402 collects the first outgoing light and converts the first outgoing light into the first optoelectronic data. Furthermore, the control device 50 obtains the first interference information in the sample to be tested according to the first optoelectronic data of the pretreatment solution of the sample to be tested.

[0109] In addition, the reagent dispensing mechanism 20 is also used to dispense the reaction reagent into the pretreatment solution to form a reaction solution. The reaction device is provided with at least one reaction position, and the reaction position is used to place the reaction vessel. The pretreatment solution contained in the reaction vessel reacts with the reaction reagent to form a reaction solution. The irradiation light emitted by the light source assembly 401 irradiates the reaction solution in the reaction vessel to form the second outgoing light. The optical signal detector 402 collects the second outgoing light to obtain the second optoelectronic data. Since the first optoelectronic data and the second optoelectronic data are obtained by irradiating the same reaction vessel successively, this method can save the sample preparation steps and shorten the detection time.

[0110] In a specific implementation manner, the first interference information in the sample to be tested is the information of the interference substance that causes the abnormal properties of the sample to be tested. The abnormal properties include abnormal physical properties such as precipitation, color, floccules, lumps, etc.

[0111] In some embodiments, a visual detection method can be used. For example, a sample analysis system can obtain a sample image of a sample to be tested (pretreatment solution of the sample to be tested) through an image acquisition module. Since the information of certain interfering substances can affect the appearance state of the sample, such as the sample becoming turbid due to lipemia, etc., the control device 50 processes and analyzes the sample image to obtain the information of the interfering substances. For example, traditional image analysis methods are used to extract at least one of the following types of image features from the sample image: edge features, gray-scale distribution features, color features, texture features, shape features, and spatial relationship features, so as to obtain the information of the interfering substances. Another example is to input the sample image into a machine learning model, and the machine learning model identifies the information of the interfering substances in the sample image. In some embodiments, the sample image is input into a preset first machine learning model to obtain the information of the interfering substances of the sample to be tested (or the pretreatment solution of the sample to be tested) output by the first machine learning model. In some embodiments, the sample image is input into a preset second machine learning model to obtain the serum index of the sample to be tested output by the second machine learning model; and based on the serum index, the information of the interfering substances of the sample to be tested (or the pretreatment solution of the sample to be tested) is obtained. The structure of the first machine learning model and the structure of the second machine learning model can be different or the same. The embodiments of the present application do not limit the structures of the first machine learning model and the second machine learning model. For example, both the first machine learning model and the second machine learning model are neural network models, and can be composed of convolutional neural networks (CNNs, Convolutional Neural Networks).

[0112] The sample to be tested is mixed with a pretreatment reagent (the pretreatment reagent includes but is not limited to physiological saline, buffer solution, diluent, etc.) to prepare a pretreatment solution. In the embodiments of the present application, although the pretreatment reagent can be called a reagent, it is different from the reaction reagent. The pretreatment reagent does not have a biochemical reaction with the sample to be tested, and only plays roles such as diluting the sample to be tested and creating a reaction environment for the sample to be tested.

[0113] The sample to be tested or the pretreatment solution of the sample to be tested is used to detect and obtain the information of the interfering substances. That is to say, this information of the interfering substances is obtained before the reaction and can represent the interference situation of the sample to be tested itself or the pretreatment solution of the sample to be tested. For the convenience of distinguishing from the information of the interfering substances in the reaction solution below, the information of the interfering substances obtained from the sample to be tested (or the pretreatment solution of the sample to be tested) is called the first interfering substance information.

[0114] The control device 50 can also analyze the optoelectronic data of the reaction solution to obtain the second interfering substance information. This information of the interfering substances is obtained by detecting the reaction solution after the sample to be tested and the reaction reagent undergo a biochemical reaction to prepare the reaction solution, and can represent the interference situation when the reaction reagent is added to the sample to be tested.

[0115] Thus, the control device 50 can comprehensively use the first interferent information and the second interferent information to determine the type or source of the interferent in the reaction solution. Specifically, in some embodiments, it can be determined that the interferent comes from the test sample itself, the reaction reagent, or the reaction process (such as the reaction cup, the stirring process, etc.). In other embodiments, the specific type of the interferent can be determined, such as lipemic interference, icteric interference, hemolytic interference, globulin interference, heparin interference, etc.

[0116] As can be seen from the above technical solutions, in the sample analysis system provided by the embodiments of the present application, the detection device can obtain one interferent information based on the test sample (or the preprocessed solution of the test sample), and obtain another interferent information based on the reaction solution of the test sample. By comprehensively using the interferent information from both aspects, the specific type or source of the interferent can be determined, thereby providing a basis for interference elimination and improving the accuracy of the sample detection result.

[0117] There are various detection methods for the first interferent information and the second interferent information. The two interferent information can be obtained in the same test or in different tests. The following will be illustrated by several specific embodiments.

[0118] In a specific embodiment, the sample dispensing mechanism aspirates a first test sample from the sample tube and dispenses it into a first reaction vessel, and aspirates a second test sample from the sample tube and dispenses it into a second reaction vessel. It should be noted that the sample dispensing mechanism can aspirate the second test sample after performing the interferent detection on the first test sample, or can aspirate the second test sample at any time before or during the interferent detection.

[0119] The first reaction vessel may or may not include the pretreatment reagent for the first test sample. The control device controls the sample analysis system to perform interferent detection on the first test sample in the first reaction vessel or the pretreatment solution prepared from the first test sample and the pretreatment reagent to obtain the first interferent information.

[0120] In clinical tests, due to reasons such as blood sampling operations, diseases, medications, or individual physiques, the blood of the human body may have samples with jaundice, lipemia, or hemolysis. Jaundice, lipemia, and hemolysis are collectively referred to as the three major interferences in biochemical clinical tests. They have pain points such as high occurrence frequency, great impact on test results, and difficulty in handling interferences that require resampling. To determine whether the above interference information exists in the sample to be tested, in some embodiments, the sample analysis system can perform a serum index test on the first sample to be tested or the pretreatment solution of the first sample to be tested to obtain the first interference information. The serum index (Hemolysis, Icterus, Lipemia, abbreviated as HIL) can reflect the interference information of the blood sample. Specifically, blood samples can be divided into the following four types: hemolytic samples, jaundiced samples, lipemic samples, and normal samples. Hemolysis H, jaundice I, and lipemia L (also known as chylous blood) are collectively referred to as HIL in the embodiments of the present application. The hemolysis index H monitors the degree of hemolysis of the specimen. The higher the value, the higher the degree of hemolysis interference; the jaundice index I monitors the degree of jaundice of the specimen. The higher the value, the higher the degree of jaundice interference; the lipemia index L monitors the turbidity of the specimen. The higher the value, the higher the degree of lipemia (turbidity) interference. Of course, other interference detection methods other than serum index detection can also be used to obtain the first interference information.

[0121] The second sample to be tested in the second reaction container and the reaction reagent are used to prepare a reaction solution, and the control device obtains the second interference information based on the optoelectronic data of the reaction solution. Among them, the second interference information can be obtained in the test item, that is, during the test process of the item, both the test result of the test item and the interference information can be obtained. Or, the second interference information can be obtained in any process specifically for interference detection.

[0122] In some embodiments, the sample analysis system performs interference detection on the first sample to be tested or the pretreatment solution of the first sample to be tested during the first item test process to obtain the first interference information; the control detection device obtains the optoelectronic data of the reaction solution during the second item test process and obtains the second interference information based on the optoelectronic data of the reaction solution; where the first item test and the second item test are different types of item tests.

[0123] In some embodiments, the sample analysis system obtains the first interference information in the serum index test and obtains the second interference information during the item test process. An example process is as Figure 3AAs shown, when applying for a serum index test in a sample analysis system, the sample analysis system injects a serum index reagent (usually a physiological saline reagent, which is a type of pretreatment reagent) into a reaction container, aspirates a sample to be tested (the first sample to be tested) from a sampling tube and injects it into the reaction container. After the sample to be tested is mixed with the serum index reagent, a pretreatment solution is prepared, and the serum index test process is used to detect the pretreatment solution to obtain a serum index test result, such as calculating the serum index by collecting absorbance information at a fixed wavelength. In addition, a biochemical test item is performed on the sample to be tested in the sampling tube. Specifically, the sample analysis system injects a reagent R1 for the test item (normally, reagent R1 does not undergo a biochemical reaction with the sample to be tested and mainly plays roles such as dilution and creating a reaction environment. Reagent R1 can be a type of pretreatment reagent) into the reaction container, aspirates a sample to be tested (the second sample to be tested) from the sampling tube and injects it into the reaction container, and then injects reagent R2 (reaction reagent) into the reaction container in portions. The sample to be tested reacts with reagent R2 to obtain a reaction solution, and the test result of this biochemical test item is obtained through the optoelectronic data of the reaction solution.

[0124] In each of the above embodiments, for the detection of the first interferent information and the second interferent information, it is necessary to aspirate the sample to be tested from the sampling tube separately and add the corresponding reagents respectively for detection. Not only is the test process relatively repetitive and cumbersome, but also reagent waste is caused. To further simplify the test process and save reagent costs, the test processes for the first interferent information and the second interferent information can be designed as the same test, that is, after the interferent detection is performed on the sample to be tested or the pretreatment solution of the sample to be tested in the reaction container to obtain the first interferent information, the control device controls the reagent dispensing mechanism to inject the reaction reagent into the reaction container in portions to prepare a reaction solution, and the optoelectronic data of the reaction solution is used to obtain the second interferent information. Since only one aspiration of the sample to be tested is required to detect the first interferent information and the second interferent information, the test steps can be saved, the test efficiency can be improved, and the waste of consumable costs related to the aspiration of the relevant sample to be tested can be saved.

[0125] Specifically, the process of obtaining the first interferent information and the second interferent information in the same test includes: the reagent dispensing mechanism aspirates the sample to be tested from the sampling tube and injects it into the reaction container. The sample analysis system can perform interferent detection on the sample to be tested in the reaction container (or the further prepared pretreatment solution) in any of the above ways to obtain the first interferent information. The reagent dispensing structure injects the reaction reagent into the reaction container to prepare a reaction solution. The detection device performs optical detection on the reaction solution to obtain the optoelectronic data of the reaction solution, and the control device analyzes the optoelectronic data to obtain the second interferent information. In some embodiments, the second interferent information can be obtained in the test item, that is, the test result of the test item can be obtained during the test process of the item, and the interferent information can also be obtained. Or, the second interferent information can be obtained in any process specifically for interferent detection.

[0126] An example process is as follows Figure 3B shown. The sample analysis system injects the reagent R1 for the test item into the reaction vessel, and aspirates the sample to be tested from the sampling tube and injects the sample to be tested into the reaction vessel. Under normal circumstances, the reagent R1 does not undergo a biochemical reaction with the sample to be tested, and mainly plays roles such as dilution and creating a reaction environment. Therefore, after adding the sample to be tested, the serum index test process can be used to detect the pretreatment solution to obtain the serum index test result (the first interferent information). Then, the reaction reagent R2 is injected into the reaction vessel. The reaction reagent R2 undergoes a biochemical reaction with the sample to be tested to prepare a reaction solution. The test result of the biochemical item can be obtained through the optoelectronic data of the reaction solution, and the second interferent information can be obtained. It should be noted that whether the serum index test process obtains a test result does not affect the action of injecting the reaction reagent R2. As long as the data collection of the pretreatment solution is completed, such as the end of image taking or the completion of optoelectronic data collection, the reaction reagent R2 can be injected into the reaction vessel. The collected data is used for analysis to obtain the serum index test result, thereby further shortening the time of the test process. In addition, in this example, the test item is a two-reagent item (reagent R1 and reagent R2). The detection of the first interferent information can rely on some of the reagents (reagent R1) for detection, without adding additional reagents to separately detect the first interferent information, thereby saving reagent costs. Of course, this advantage can be extended to multi-reagent items.

[0127] The optoelectronic data of the reaction solution can include the light signal intensities of multiple different wavelengths, and / or, include a signal sequence formed by the light signal intensity of the same wavelength and time. By comparing and analyzing the light signal intensities of different wavelengths, and / or, analyzing each light signal intensity in the signal sequence of the same wavelength, the interferent information of the reaction solution can be obtained. The interferent information is used to characterize the interferent situation of the reaction solution, such as the specific interferents present in the reaction solution (such as lipid particles).

[0128] Method 1: When the control device 50 obtains the second interferent information of the reaction solution according to the optoelectronic data, the following steps are specifically executed: Extract at least one characteristic interference quantity from the optoelectronic data, and obtain the second interferent information of the reaction solution according to the at least one characteristic interference quantity. The characteristic interference quantity is a signal characteristic used to identify abnormalities.

[0129] Specifically, if the optoelectronic data includes the light signal intensities of multiple wavelengths, the light signal intensities at the same position in the reaction solution at the same time period of multiple wavelengths can be obtained. The optoelectronic data between these multiple wavelengths has reference significance. Therefore, the interferent information of the reaction solution can be obtained by comparing the light signal intensities at the same position in the same time period of different wavelengths. The characteristic interference quantities extracted from the light signal intensities of multiple wavelengths include, but are not limited to, the range of the interference wavelength band.

[0130] If the optoelectronic data includes a signal sequence of the correspondence between the light intensity signal of the same wavelength and time, the signal sequence can be represented as a pulse waveform (or called a signal curve), and at least one of the following characteristic interference quantities can be extracted from the optoelectronic data of each wavelength, such as the peak value, valley value, pulse start point, pulse end point, pulse width, full width at half maximum, specific width, area, slope, rise time, and fall time of the signal curve corresponding to the signal sequence. At least one characteristic interference quantity is used to determine the interferent information of the reaction solution. For example, whether the reaction solution is abnormal can be determined by the number of wave peaks or wave valleys of the signal sequence of the same reaction solution in multiple detection cycles.

[0131] The optoelectronic data of the reaction solution can be plotted to obtain a reaction curve (reaction spectrum), and it can be judged whether it is affected by a certain interference through the reaction curve of the reaction solution and multiple interference characteristic quantities. For example, the interference in the detection item (the detection item does not have a reaction characteristic for this interference) is identified through a three-dimensional reaction curve. Specifically, if the biochemical reaction of the detection item has a reaction characteristic at wavelengths 1-5, and a certain interference has a reaction characteristic at wavelength 7, then wavelength 7 is considered as the interference characteristic quantity of this interference. When the interference characteristic quantity exceeds the normal threshold, it is considered that the detection item of this sample is affected by this interference.

[0132] Method 2: When the control device 50 obtains the second interferent information of the reaction solution according to the optoelectronic data, the following steps are specifically executed: input the optoelectronic data into a preset first machine learning model, and obtain the second interferent information of the reaction solution output by the first machine learning model for the optoelectronic data. For example, the absorbance or reactivity can be calculated using the light intensity signal in the optoelectronic data, and the absorbance or reactivity is input into the first machine learning model, and the first machine learning model can output whether the reaction solution is abnormal and / or the type of interferent in the reaction solution.

[0133] Wherein the first machine learning model can be a neural network model, and the first machine learning model can be a machine learning model trained with optoelectronic data sample data, so that the first machine learning model has the ability to identify the interferent information of the reaction solution, so that the optoelectronic data can be input into the first machine learning model that has been pre-trained to obtain the interferent information of the reaction solution. The neural network model can be a network model of any existing structure, including but not limited to a convolutional neural network.

[0134] The first interferent information includes at least one of a signal waveform, an interferent content, and an interferent type; the second interferent information includes at least one of a signal waveform, an interferent content, and an interferent type. The signal waveform may be the correspondence between the optical signal intensity and the acquisition time, that is, the optoelectronic data is represented in the form of a signal waveform. Since the signal waveform with interference is different from the normal signal waveform, the interferent information can be determined through the signal waveform. The interferent type is used to represent the specific interferent causing the interference, such as lipemic interference, jaundice interference, hemolytic interference, globulin interference, heparin interference, and so on. The interferent content is used to represent the degree of interference caused by the interferent, which can not only represent the interferent type but also quantify the degree of interference caused by the interferent.

[0135] In some embodiments, when the first interferent information includes a first signal waveform and the second interferent information includes a second signal waveform, when determining the interferent type or the source of the interferent of the reaction solution according to the first interferent information and the second interferent information, the control device 50 is specifically configured to: determine the source of the interferent based on the first signal waveform and the second signal waveform.

[0136] Based on the foregoing, it can be understood that the first signal waveform is the interferent information of the sample to be tested (or the pretreated solution of the sample to be tested), and the second signal waveform is the interferent information obtained after adding the reaction reagent to the sample to be tested to prepare the reaction solution. By comparing the differences between the first signal waveform and the second signal waveform, it can be determined whether there is an interferent and the source of the interferent in the case of the existence of the interferent. If the first signal waveform is an abnormal signal waveform and the second signal waveform is an abnormal signal waveform, it indicates that the interferent probably comes from the sample to be tested; if the first signal waveform is a normal signal waveform and the second signal waveform is an abnormal signal waveform, it indicates that the interferent probably comes from the reaction reagent added to the sample to be tested or from the reaction process; if the first signal waveform is an abnormal signal waveform and the second signal waveform is a normal signal waveform, it indicates that the detection is abnormal or the interferent probably comes from the sample to be tested; if the first signal waveform is a normal signal waveform and the second signal waveform is a normal signal waveform, it indicates that there is no interferent. In the absence of other interference information assistance, the situation with a higher probability can be used as the source of the interferent.

[0137] In some embodiments, when the first interferent information includes a first interferent content and the second interferent information includes a second interferent content, when determining the interferent type or the source of the interferent of the reaction solution according to the first interferent information and the second interferent information, the control device 50 is specifically configured to: determine the interferent type of the reaction solution based on the first interferent content and the second interferent content.

[0138] Specifically, based on the first interferent content and the second interferent content, not only can the type of interferent be determined, but also the degree of interference corresponding to the type of interferent can be determined. For example, if the first interferent content indicates that the lipemic interference content is 10, and the second interferent content indicates that the overall lipemic interference content and globulin interference content is 100, then by combining the first interferent content and the second interferent content, the globulin interference content can be determined to be 90. Of course, when determining the content of a certain type of interferent by comprehensively considering the two types of interferent contents, it is not limited to subtraction, and the corresponding calculation method can be set according to the specific type of interference.

[0139] In some embodiments, when the first interferent information includes the first interferent type and the second interferent information includes the second interferent type, when determining the interferent type or the source of interferent of the reaction solution according to the first interferent information and the second interferent information, the control device 50 is specifically configured to: determine the interferent type of the reaction solution based on the first interferent type and the second interferent type.

[0140] For example, determine the common interferent type in the first interferent type and the second interferent type as the interferent type of the reaction solution; or, if the first interferent type does not include a specific interferent type and the second interferent type includes the specific interferent type, exclude the specific interferent type from the second interferent type and use the remaining second interferent type as the interferent type of the reaction solution, where the specific interferent type is an interferent type preset according to the actual situation. In actual situations, the interferent type that can be accurately detected when detecting the interferent in the test sample (or pretreatment solution) can be determined as the specific interferent type. For example, detect whether the test sample (or pretreatment solution) is turbid by serum index detection or visual image detection, so as to accurately judge whether there is lipemic interference. If there is no lipemic interference in the first interferent type, but there is lipemic interference and other interferent types in the second interferent type, then the lipemic interference can be excluded from the second interferent type to obtain the interferent type of the reaction solution.

[0141] The following takes the creatinine item and the creatine kinase item as examples to illustrate the process of determining the interferent type.

[0142] When the test item is the creatinine item, after the control device 50 obtains the first interferent type and the second interferent type, if the first interferent type includes lipemic interference and the second interferent type detected by the creatinine item detection includes globulin interference and lipemic interference, then determine the interferent type of the reaction solution as the common interferent type: lipemic interference. If the first interferent type does not include lipemic interference and the second interferent type detected by the creatinine item detection includes globulin interference and lipemic interference, then exclude the lipemic interference from the second interferent type to determine the interferent type of the reaction solution as globulin interference.

[0143] TakeFigure 4A and Figure 4B Taking the creatinine item shown as an example, a three-dimensional spectrogram is plotted based on the optoelectronic data of the reaction solution. In the three-dimensional spectrogram, the X-axis is the acquisition time, the Y-axis is the absorbance, and the Z-axis is the wavelength band of different wavelengths. Figure 4A and Figure 4B The trend of the three-dimensional spectral curve of Figure 4A does not match the trend of the three-dimensional spectral curve of the normal creatinine item. According to the trend of the three-dimensional spectral curve of Figure 4B it can be determined that there is globulin interference, and according to the trend of the three-dimensional spectral curve of

[0144] When the detection item is the creatine kinase item, after the control device 50 obtains the first type of interfering substance and the second type of interfering substance, if the first type of interfering substance includes lipemia interference, and the second type of interfering substance detected in the creatine kinase item includes globulin heparin interference and lipemia interference, then it is determined that the interfering substance type of the reaction solution is lipemia interference; if the first type of interfering substance does not include lipemia interference, and the second type of interfering substance detected in the creatine kinase item includes heparin interference and lipemia interference, then it is determined that the interfering substance type of the reaction solution is heparin interference.

[0145] The embodiments of the present application provide a specific process for jointly judging the type of interfering substance. As Figure 5 shown, the sample analysis system adds reagent R1 to the reaction container, adds the test sample to the reaction container, performs a serum index test on the pretreatment solution of the test sample and reagent R1 to obtain a serum index test result (the first interfering substance information). Reagent R2 is added to the reaction container. After the reagent R2 undergoes a biochemical reaction with the test sample, a reaction solution is obtained. The optoelectronic data of the reaction solution is collected and the optoelectronic data is generated into a three-dimensional spectrum. The three-dimensional spectrum is analyzed to obtain interfering substance information (the second interfering substance information). Combining the serum index test result and the interfering substance information to obtain the source or type of the interfering substance. For example, according to the serum index test result, it can be judged whether there is lipemia interference, and then according to whether lipemia interference is included in the interfering substance information, it can be accurately judged whether there is lipemia interference. If only the three-dimensional spectrum is used to judge whether there is lipemia interference, since lipemia interference has a response to the entire wavelength band, it is very easy to confuse or misjudge lipemia interference with other interferences during judgment, resulting in an inaccurate interference judgment result. This embodiment can combine the serum index to judge whether there is lipemia interference on the basis of the three-dimensional spectrum judgment, so as to more accurately determine whether there is lipemia interference and improve the accuracy of interference judgment.

[0146] In some embodiments, the optoelectronic data can be obtained during the project detection process. Therefore, the control device 50 can also be used to obtain the test result of the test sample for the detection project according to the optoelectronic data. In a specific implementation, the optoelectronic data of the detection project can be used to generate a spectral curve of the detection project. The abscissa of the spectral curve is the acquisition time, and the ordinate is the absorbance or reactivity. The test result of the detection project can be obtained by analyzing the spectral curve. It should be noted that the spectral curve can be a two-dimensional reaction curve or a three-dimensional spectrogram. In the three-dimensional spectrogram, the optoelectronic data collected by the detection device includes signal sequences of multiple wavelengths. Refer to Figure 6A the provided normal three-dimensional spectrogram of the creatine kinase (CK) project. In this three-dimensional spectrogram, the X-axis is the acquisition time, the Y-axis is the absorbance, and the Z-axis is the wavelength segment of different wavelengths. The detection concentration of creatine kinase in the blood sample can be obtained by analyzing the absorbance of multiple wavelengths in this three-dimensional spectrogram.

[0147] Since there may be interference in the test sample or the reaction solution prepared from the test sample, the test result obtained from the optoelectronic data of the reaction solution is not accurate enough. To improve the accuracy of the test result, the optoelectronic data corresponding to the detection project can be corrected to obtain a more accurate test result. Therefore, when obtaining the test result of the test sample for the detection project according to the optoelectronic data, the control device 50 can specifically be used to: correct the optoelectronic data according to the source or type of the interfering substance to obtain the test result of the detection project. That is to say, the test result obtained by the control device is the corrected test result.

[0148] Another correction method can be to first obtain a preliminary test result using the second optoelectronic data, then obtain a test result correction amount using the source or type of the interfering substance, and use the correction amount to correct the preliminary test result to obtain the test result of the control device 50. That is to say, the initial test result of the detection project in the test sample is obtained according to the second optoelectronic data, and the initial test result is corrected according to the type or source of the interfering substance to obtain the test result of the detection project in the test sample.

[0149] In some embodiments, when correcting the second optoelectronic data according to the source of the interferent or the type of the interferent to obtain the detection result of the detection item, the control device 50 is configured to: determine the optoelectronic data corresponding to the detection wavelength of the detection item and the optoelectronic data corresponding to the interference wavelength of the interferent in the second optoelectronic data (the interferent is determined by the type of the interferent or the source of the interferent); use the optoelectronic data corresponding to the interference wavelength to correct the optoelectronic data corresponding to the detection wavelength, and obtain the detection result of the detection item based on the corrected optoelectronic data corresponding to the detection wavelength. It can be understood that in the case where the reaction solution is interfered, the optoelectronic data collected by the detection device includes both the optoelectronic data corresponding to the interferent and the optoelectronic data corresponding to the detection item. Therefore, the two types of optoelectronic data are respectively extracted from the optoelectronic data. Specifically, the optoelectronic data includes optoelectronic data of different wavelengths. The wavelengths of the optical signals generated by the interferent and the detection substance corresponding to the detection item may be different. Therefore, the optoelectronic data corresponding to the interferent and the optoelectronic data of the detection item are respectively extracted from the optoelectronic data according to the wavelength range. Then, the optoelectronic data of the detection item is corrected by using the optoelectronic data of the interferent to obtain a more accurate detection result.

[0150] In some embodiments, to correct the influence of interference on the detection result, the control device 50 is specifically configured to execute steps A1 - A2. A1: Determine the optoelectronic data corresponding to the detection wavelength of the detection item and the optoelectronic data corresponding to the interference wavelength of the interferent in the second optoelectronic data; the interferent is determined by the type of the interferent or the source of the interferent; A2: Determine the initial detection result according to the optoelectronic data corresponding to the detection wavelength; determine the interference amount caused by the interferent according to the optoelectronic data corresponding to the interference wavelength; correct the initial detection result according to the interference amount to obtain the detection result of the detection item.

[0151] In this implementation manner, the control device 50 first analyzes the optoelectronic data of the detection wavelength to obtain the detection result of the detection item (this detection result has a deviation from the accurate result due to interference. For the convenience of distinguishing from the corrected detection result below, it can be called the initial detection result). It can be understood that the detection result can represent the proportion of the detection substance corresponding to the detection item in the sample to be tested. Similarly, the optoelectronic data of the interference wavelength can be used to determine the detection result of the interferent, that is, the proportion in the sample to be tested. This part can be considered as the proportion of the influence of the interferent on the detection result, so it can be called the interference amount. The initial detection result is corrected by using the interference amount, such as subtracting the interference amount from the initial detection result to obtain the corrected detection result.

[0152] In practical applications, interference calculation formulas can be used for interference elimination. The interference calculation formula combines the characteristics of interference optoelectronic data at different time points in different bands. For example, according to the change of the three-dimensional absorbance curve caused by the interfering substance, the influence of interference on the detection result can be eliminated. If the types of interfering substances affecting the detection item are different, different interference calculation formulas corresponding to different types of interfering substances are used for interference elimination. The interference calculation formula can include spectral information at different wavelengths. For example, an interference calculation formula is x*[a]+y*[b]-z*[c], where x, y, and z are preset coefficients, and a, b, and c are the absorbances at the corresponding wavelengths.

[0153] Taking the creatine kinase (CK) detection item as an example, a reaction solution is prepared using CK reagent. As Figure 6A shown, the normal three-dimensional spectrum of the CK detection item only has spectral peaks below 400 nm, so its main wavelength is 340 nm. Once hemolysis interference occurs, see Figure 6B an example diagram of the hemolysis spectrum of the CK detection item provided. Under hemolysis interference, the spectral peak at wavelength 340 nm will be elevated, thus bringing a positive deviation to the detection result. The multi-wavelength interference calculation and processing method is as follows: Capture the characteristic peaks brought by interference, especially the characteristic peak at wavelength 412 nm, because normal CK detection does not generate optoelectronic data in this band, and only hemolysis interference has a corresponding strong characteristic peak in this band. Therefore, it is determined whether the hemolysis interference exceeds the acceptance threshold through the spectral information at wavelength 412 nm, and the hemolysis interference is quantified through this wavelength peak. The interference amount brought by hemolysis interference in the spectral information at wavelength 340 nm is calculated through the normalization coefficient formula and eliminated, so as to restore the chemical reaction between the CK detection item and the reagent to the greatest extent and maximize the approximation to the true detection result of the CK detection item. The interference calculation formula corresponding to the hemolysis interference of the CK detection item is x*[absorbance corresponding to wavelength 340 nm]-y*[absorbance corresponding to wavelength 412 nm]. The absorbance after interference elimination is further converted to obtain the corrected CK detection result. It should be noted that for the CK detection item, other interference characteristic quantities and interference calculation formulas can also be set according to the spectral information.

[0154] Different types of interference have different characteristics and manifestations. The interference calculation formula can quantify the degree of interference of the sample to be tested, so as to correct the detection result of the detection item.

[0155] Another correction method can be to first correct the second optoelectronic data using the source of the interfering substance or the type of interfering substance, and then analyze the corrected optoelectronic data to obtain the detection result of the detection item. That is to say: Correct the second optoelectronic data according to the type of interfering substance or the source of the interfering substance, and obtain the detection result of the detection item in the sample to be tested based on the corrected second optoelectronic data.

[0156] In some embodiments, to correct the influence of interference on the detection result, the control device 50 is specifically configured to execute steps B1 - B2. B1: Determine the optoelectronic data corresponding to the detection wavelength of the detection item and the optoelectronic data corresponding to the interference wavelength of the interferent in the second optoelectronic data; the interferent is determined by the interferent type or the interferent source; B2: Correct the optoelectronic data corresponding to the detection wavelength according to the optoelectronic data corresponding to the interference wavelength, and obtain the detection result of the detection item based on the corrected optoelectronic data corresponding to the detection wavelength.

[0157] The control device 50 first corrects the optoelectronic data of the detection wavelength, and then analyzes the corrected optoelectronic data of the detection wavelength to obtain the detection result of the detection item, and this detection result is closer to the true result of the sample to be tested. The correction methods of the optoelectronic data of the detection wavelength include but are not limited to: multi - band fitting correction, function correction.

[0158] For example, one way is that if the optoelectronic data of the interference wavelength includes optoelectronic data of multiple wavelengths, then fit the optoelectronic data of multiple wavelengths to obtain interference - fitting optoelectronic data; subtract the interference - fitting optoelectronic data from the optoelectronic data of the detection wavelength to correct the optoelectronic data of the detection wavelength. Taking the reactivity spectrum as an example, plotting the optoelectronic data of the reaction solution in a coordinate system can generate the reactivity spectrum. Fit the band data affected by interference in the reactivity spectrum to obtain the interference spectrum, subtract the interference spectrum from the detection wavelength data to obtain a spectrum closer to the interference - free state, and the detection result calculated using this spectrum is more accurate. The absorbance spectrum can be corrected in the same way by referring to the above process.

[0159] Assume that the optoelectronic data includes optoelectronic data of bands 1, 2, 3... n. According to whether the change in the optical signal intensity of the band is only related to the target interference, select some or all of the optoelectronic data of the bands for fitting. For example, select the optoelectronic data of bands 1, 2, m (m ≤ n), use a specific function to fit the reactivity of the selected bands to obtain the fitting spectrum, use the optoelectronic data of the detection wavelength to generate the original reactivity spectrum, subtract the fitting spectrum from the original reactivity spectrum to obtain the corrected reactivity spectrum, and then use the corrected reactivity spectrum to calculate the detection result of the detection item. The absorbance spectrum can be corrected in the same way by referring to the above process.

[0160] Another way is, for example, select N primary - secondary wavelength combinations in the optoelectronic data of the detection wavelength, determine the standard function corresponding to each primary - secondary wavelength combination; select the empirical function of the interference caused by the interferent source or interferent type to each primary - secondary wavelength combination; for the same primary - secondary wavelength combination, combine the corresponding standard function and the corresponding empirical function to obtain the superimposed spectral function; solve the superimposed spectral functions corresponding to the N primary - secondary wavelength combinations to obtain the corrected detection result of the detection item.

[0161] Taking the reactivity spectrum as an example, at least one set of primary and secondary wavelengths is selected, and the wavelength combinations of at least one set of primary and secondary wavelengths need to meet the following conditions: The reactivity calculated under wavelength combination 1 is brought into the calibration curve corresponding to this wavelength combination to obtain concentration C1; the reactivity calculated under wavelength combination 2 is brought into the calibration curve corresponding to this wavelength combination to obtain concentration C2; the reactivity calculated under wavelength combination n is brought into the calibration curve corresponding to this wavelength combination to obtain concentration Cn. If multiple concentrations (C1, C2... Cn) are close enough or the range is within a small threshold, it indicates that these multiple wavelength combinations meet the conditions. The absorbance spectrum can be similarly referred to the above correction process.

[0162] It can be understood that the measured reactivity spectrum of each wavelength combination is a linear superposition of the interference spectrum and the target reactivity spectrum. Therefore, after selecting each wavelength combination, a set of equations can be obtained according to the empirical function of the interference spectrum and the calibration curve of the corresponding wavelength combination, where the unknowns are the parameters in the empirical function and the concentration. Then, as long as the number of equations in this set of equations is greater than the number of unknowns, the theoretical true concentration can be obtained. The number of equations depends on the number of wavelength combinations, that is, if the number of parameters in the empirical function is N, then the number of wavelength combinations required is N + 1 groups. The absorbance spectrum can be similarly referred to the above correction process.

[0163] To enable the user to know the specific content of the interferent source or interferent type, the control device is also used to output interference prompt information according to the interferent source or interferent type when the interferent source or interferent type indicates the existence of interference, so that the user can perform interference elimination according to the interferent source or interferent type. The interference prompt information includes but is not limited to whether there is interference, interferent type, interferent source, detection item affected by interference, the impact on the detection result of the detection item (such as positive impact, negative impact, degree of impact), etc. In some embodiments, the sample analysis system may include a display device, and the control device controls the display device to output the above interference prompt information. The display device can be integrated into a single sample analysis device in the form of a display screen, or can be set independently of the sample analysis device. For example, in a pipeline system, a pipeline large screen can be set to display the operation status of each sample analysis device. In other embodiments, the sample analysis system may not include a display device, and the control device sends the interference prompt information to the display device for output display. Or the control device is also used to output the detection result of the detection item, and / or, output the interferent type or interferent source of the reaction solution.

[0164] It is understandable that in the presence of interfering substances, the interfering substances may affect the test results of the items in the sample to be tested. In order to enable users to intuitively understand whether the interfering substances have an impact on the test results of the items and what specific impact they have, the interference prompt information may include the impact relationship between the type of interfering substance and the test results of the items. For example, the impact relationship includes positive interference, negative interference, and irrelevance. Positive interference means that the interfering substance makes the test result of the item higher, negative interference means that the interfering substance makes the test result of the item lower, and irrelevance means that the interfering substance does not affect the test result of the item. It should be noted that the impact of the same interfering substance on different test items may be different.

[0165] After the interference prompt information is output, users can understand the test items affected by the interfering substances and how they affect the test items based on the interference prompt information, which helps to correct the test results of the items.

[0166] The interference prompt information may also include the degree of interference caused by the interference. For example, the degree of interference is represented by an interference level, and the degree of interference includes no interference, mild interference, moderate interference, and severe interference. In some embodiments, the interfering substance information may be represented as the content of the interfering substance. Corresponding content threshold intervals are set for each interference level in advance, and the interference level is determined according to the content threshold interval into which the detected interfering substance content falls.

[0167] Take Figure 7 the shown interference detection process as an example. The content of the interfering substance can be obtained by performing a serum index test on the pretreatment solution of the sample to be tested and reagent R1. In addition, the test results of the items are obtained by performing a test on the reaction solution of the sample to be tested and reagent R2. Assume that the test items include test item A, test item B, and test item C, and assume that test item A is affected by lipemia interference, test item B is affected by hemolysis interference, and test item C is affected by jaundice interference.

[0168] If the lipemia interference content is greater than threshold 2 and less than threshold 3, and the impact relationship between test item A and lipemia interference is negative interference, then a prompt message can be added to the test result of test item A: This sample is significantly interfered, the detected concentration result is low, and the possibility of false negative needs to be considered.

[0169] If the hemolysis interference content is greater than threshold 3, then a prompt message can be added to the test result of test item B: This sample is severely interfered, and the sample needs to be recollected.

[0170] If the jaundice interference content is greater than threshold 1 and less than threshold 2, then a prompt message can be added to the test result of test item C: This sample is slightly interfered, and this result is still credible.

[0171] When the interference prompt information includes the influence relationship between the interfering substance and the detection item and the interference level caused by the interfering substance, the interference prompt information quantifies the interference, which can help the user understand whether the detection result of the detection item is interfered and to what extent.

[0172] In some embodiments, if the interfering substance source or interfering substance type indicates the existence of an interfering substance, the sample analysis system can automatically handle the interference: retesting the sample to be tested or retrieving the sample to be tested. The interference handling includes but is not limited to: performing interference handling according to the first interfering substance information, or performing interference handling according to the interfering substance source or interfering substance type obtained from the first interfering substance information and the second interfering substance information. It should be noted that the interference elimination method performed before retesting is related to the interference type. For example, if there is lipemia interference, methods such as dilution by reduction can be used to eliminate the interference. If there is hemolysis interference, blood can be recollected, etc.

[0173] When the interfering substance source or interfering substance type indicates the first severity level of the interference degree, the interference is eliminated and retested. When the interfering substance source or interfering substance type indicates the second severity level of the interference degree, the sample to be tested is directly retrieved, such as transporting the sample tube to the retrieval position. After obtaining the interfering substance source or interfering substance type by combining the first interfering substance information and the second interfering substance information, using the interfering substance source or interfering substance type for interference handling has a higher accuracy of the processing basis compared to directly using the first interfering substance information for automatic processing.

[0174] However, to further save the sample testing time, simplify the repeated steps, and improve the testing efficiency, the sample to be tested can be directly retested or retrieved according to the first interfering substance information after obtaining the first interfering substance information. The following explains the advantages of this retesting method in simplifying the testing process through a comparative analysis of two retesting processes.

[0175] For example Figure 8A , in a testing process, reagent R1, the sample to be tested, and reagent R2 are respectively dispensed into the reaction container. After preparing the reaction solution, interference detection is performed. It is detected that there is lipemia interference in the reaction solution, then the sample to be tested is diluted, and reagent R1, the diluted sample to be tested, and reagent R2 are respectively redispensed into the reaction container. After preparing the reaction solution, item detection is performed to obtain an interference-free detection result.

[0176] For example Figure 8B, in a test process, the first interferent information is identified through serum index testing. If the first interferent information indicates the presence of lipemic interference, the sample to be tested is directly diluted, and then reagent R1, the diluted sample to be tested, and reagent R2 are respectively dispensed into a reaction vessel. After preparing the reaction solution, the item is tested to obtain an interference-free test result. It can be seen that this test process avoids detecting interference after the test is completed, directly detects and processes interference before adding reagents, saving test steps and improving test efficiency.

[0177] In specific implementation, if the first interferent information indicates that the degree of interference of the sample to be tested reaches the first severity level, the sample to be tested is first processed accordingly according to the interference type corresponding to the first sample state, and then the sample dispensing mechanism is controlled to aspirate the sample from the processed sample to be tested and transport it to the reaction vessel, and the reagent dispensing mechanism is controlled to dispense the reagent into the reaction vessel. After preparing the reaction solution in the reaction vessel, the test of the test item is carried out. If the first interferent information indicates that the degree of interference of the sample to be tested reaches the second severity level, the sample recovery tube is controlled.

[0178] To further improve the recognition accuracy of the interferent source or interferent type, in some embodiments, the interference determination can be combined with the optoelectronic data of the reagent. Specifically, the control device can control the reagent dispensing mechanism to dispense the reagent into the reaction vessel, and obtain the optoelectronic data of the reagent collected by the optical signal detector after the reagent is added to the reaction vessel; control the sample dispensing mechanism to dispense the sample to be tested into the reaction vessel (if the aforementioned reagent is a pretreatment reagent, control the reagent dispensing mechanism to dispense the reaction reagent into the reaction vessel), and the sample to be tested in the reaction vessel and the reagent are used to prepare the reaction solution; determine the interferent source or interferent type of the reaction solution according to the first interferent information of the sample to be tested, the second interferent information of the reaction solution, and the optoelectronic data of the reagent.

[0179] When there is only reagent in the reaction vessel, the reagent state in the reaction vessel, such as the pH value of the reagent, can be obtained according to the optoelectronic data or the absorbance or transmittance obtained from the optoelectronic data, and whether the reagent is abnormal is determined according to the obtained reagent state, such as the reagent bottle has been opened for too long, the reagent has expired, or the reagent has deteriorated, etc.

[0180] In some embodiments, optoelectronic data (third optoelectronic data) of the reaction reagent can also be obtained, and then interference information (third interference information) in the reaction reagent can be obtained. Specifically, the irradiation light emitted by the light source assembly forms outgoing light (third outgoing light) after irradiating the reaction reagent, and the optical signal detector collects the third outgoing light and converts the third outgoing light into third optoelectronic data; the control device is further configured to obtain the third interference information in the reaction reagent according to the third optoelectronic data. Among them, the third outgoing light of the reaction reagent can be collected before the reaction solution is prepared: that is, after the reaction reagent is dispensed in the reaction vessel and before the test sample is dispensed, the optical signal detector collects the third outgoing light.

[0181] Furthermore, the control device comprehensively determines the source or type of the interference in the reaction solution based on the first interference information, the second interference information, and the third interference information.

[0182] For example, the common interference types in the first interference information, the second interference information, and the third interference information can be used as the source or type of the interference. In some embodiments, if the third interference information indicates that the interference source is the test sample or the reagent, but the first interference information indicates that there is no interference in the test sample, and the second interference information indicates that there is interference in the reagent, then it can be determined that the interference source is the reagent.

[0183] It can be seen that in this embodiment, the source or type of the interference can be determined by combining the status information of the test sample, the status information of the reaction solution, and the status information of the reagent, and the determination result of the interference is more accurate.

[0184] The embodiment of the present application further provides a sample analysis system, which can correct the detection result of the detection item according to the first interference information and the second interference information, so that the sample analysis system excludes interference and outputs a detection result closer to the true sample situation. The sample analysis system provided by the embodiment of the present application includes: a sample preparation device, a detection device, and a control device.

[0185] The sample preparation device is used to prepare a reaction solution by using at least part of the test sample and the reaction reagent;

[0186] The detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms first outgoing light after irradiating the pretreatment solution or at least part of the test sample, the optical signal detector collects the first outgoing light to obtain first optoelectronic data, the irradiation light forms second outgoing light after irradiating the reaction solution, and the optical signal detector collects the second outgoing light to obtain second optoelectronic data; wherein, the pretreatment solution is prepared by the sample preparation device by using at least part of the test sample and a pretreatment reagent.

[0187] A control device, configured to obtain first interferent information in a sample to be tested according to first optoelectronic data; obtain second interferent information in a reaction solution according to second optoelectronic data; correct the second optoelectronic data according to the first interferent information and the second interferent information, and obtain a test result of a test item of the sample to be tested based on the corrected second optoelectronic data.

[0188] In a specific embodiment, the sample analysis system includes a sample dispensing mechanism, a reagent dispensing mechanism, a reaction device, a detection device, and a control device. Only the detection device and the control device are briefly described below. For the descriptions of other parts, reference can be made to the relevant descriptions of the above embodiments, which will not be elaborated here.

[0189] It should be noted that the detection device collects optoelectronic data for a specific test item, that is, for the test item to be detected. During the detection of this item, the light source assembly is used to generate irradiation light. After the irradiation light irradiates the reaction vessel, outgoing light is formed, and the optical signal detector collects the outgoing light to obtain optoelectronic data.

[0190] A control device, configured to control the sample analysis system to perform interferent detection on a sample to be tested or a pretreatment solution of the sample to be tested to obtain first interferent information, where the pretreatment solution is prepared from the sample to be tested and a pretreatment reagent; obtain second interferent information according to the optoelectronic data of the reaction solution; correct the optoelectronic data according to the first interferent information and the second interferent information to obtain a test result of the test item.

[0191] In some embodiments, the optoelectronic data of the test item is corrected respectively according to the first interferent information and the second interferent information, and a more accurate test result is obtained by using the corrected optoelectronic data.

[0192] In other embodiments, interferent information is obtained according to the first interferent information and the second interferent information; the optoelectronic data is corrected by using the interferent information to obtain a test result of the test item. For the specific description of this embodiment, reference can be made to the above relevant description, which will not be elaborated here.

[0193] An embodiment of the present application further provides a sample analysis system, including a sample dispensing mechanism, a reagent dispensing mechanism, a reaction device, a detection device, and a control device. Only the acquisition device and the control device are briefly described below. For the descriptions of other parts, reference can be made to the relevant descriptions of the above embodiments, which will not be elaborated here.

[0194] The control device is configured to, when it is determined based on the sample to be tested or the pretreatment solution of the sample to be tested that there are interfering substances in the sample to be tested, control the sample analysis system to process the sample to be tested to remove the interfering substances in the sample to be tested; control the sample dispensing mechanism to dispense the processed sample to be tested into the reaction vessel, and the sample to be tested and the reaction reagent are used to prepare a reaction solution in the reaction vessel. The detection device can collect the optoelectronic data of the reaction solution during the project detection process, and the control device obtains the detection result of the project according to the optoelectronic data of the reaction solution.

[0195] In this embodiment, the sample analysis system can process the sample to be tested and then perform the project detection process when there are interfering substances in the sample to be tested, so as to ensure the accuracy of the detection result of the detection project. In the existing project detection process, if interfering substances are found after obtaining the detection result of the project, the sample to be tested is processed and the project detection process is performed again, resulting in unnecessary repetition and cumbersome of the detection process, reducing the project test efficiency and causing reagent waste. Compared with the prior art, the embodiment of the present application can detect possible interfering substances before the reaction solution of the sample to be tested is prepared, and perform the project test after removing the interference, thereby saving reagent costs and improving the project detection efficiency.

[0196] The embodiment of the present application further provides a sample analysis system, including a sample preparation device, a detection device, an acquisition device and a control device.

[0197] The sample preparation device is used to prepare a reaction solution by using at least part of the sample to be tested and the reaction reagent. In a specific implementation manner, the sample preparation device may include a sample dispensing mechanism, a reagent dispensing mechanism and a reaction device. The detection device includes a light source assembly and a light signal detector; the light source assembly is used to generate irradiation light, and the irradiation light forms outgoing light after irradiating the reaction solution, and the light signal detector collects the outgoing light to obtain optoelectronic data.

[0198] The following only briefly describes the acquisition device and the control device. For the description of other parts, reference can be made to the relevant descriptions of the above embodiments, which will not be elaborated here.

[0199] The acquisition device is used to obtain the first interfering substance information of the sample to be tested or the pretreatment solution of the sample to be tested, and the pretreatment solution is prepared by the sample to be tested and a pretreatment reagent.

[0200] Among them, the first interferent information can be sent by other devices to the sample analysis system. That is, the acquisition device can be a communication interface, and the sample analysis system receives the first interferent information sent by other devices through the communication interface. For example, the other device is an image analysis device, including an image capture module and an image processing module. The image capture module can take a photo of the sample to be tested (or the pretreatment solution) to obtain a sample image, and the image processing module obtains the first interferent information after identifying the sample image. The image analysis device sends the first interferent information to the sample analysis system. Alternatively, the other device is a sample analysis device. The sample analysis device can detect the sample to be tested or the pretreatment solution of the sample to be tested to obtain optoelectronic data, obtain the first interferent information in the sample to be tested according to the optoelectronic data, and send the first interferent information to the sample analysis system.

[0201] The control device is configured to obtain the second interferent information in the reaction solution according to the optoelectronic data of the reaction solution; and jointly determine the type or source of the interferent in the reaction solution according to the first interferent information and the second interferent information.

[0202] An embodiment of the present application further provides a sample analysis system, including: a sample preparation device, a detection device, and a control device.

[0203] The sample preparation device is used to prepare a reaction solution by using at least part of the sample to be tested and a reaction reagent.

[0204] The detection device is used to detect the pretreatment solution or the sample to be tested to obtain a first detection parameter and detect the reaction solution to obtain a second detection parameter; wherein the pretreatment solution is prepared by the sample preparation device by using at least part of the sample to be tested and a pretreatment reagent.

[0205] Among them, the first detection parameter refers to a parameter obtained by detecting the interferent in the pretreatment solution or the sample to be tested, and the first detection parameter is used to obtain the first interferent information in the sample to be tested.

[0206] For example, the first detection parameter is obtained by using image processing technology. Correspondingly, the first detection parameter includes image parameters. A sample image of the sample to be tested (or the pretreatment solution of the sample to be tested) is taken to obtain a sample image of the sample to be tested (or the pretreatment solution of the sample to be tested), and after analyzing the sample image, image parameters are obtained. The image parameters are used to represent the first interferent information of the sample to be tested. It can be understood that the image parameters can reflect the physical properties of the sample to be tested (such as color, turbidity, precipitation, lumps, flocs, etc.), and the image parameters can include but are not limited to color, pixel depth, resolution, bit depth, hue, saturation, brightness, color channels, etc.

[0207] For another example, the first detection parameter is obtained by using an optical analysis technique, and correspondingly, the first detection parameter includes optoelectronic data. The specific process of using the optical analysis technique to detect and obtain optoelectronic data can refer to the relevant descriptions of the above light source assembly and optical signal detector, which will not be elaborated here. Further, the optical analysis technique may include PDR technology, and the optoelectronic data includes PDR optoelectronic data.

[0208] Among them, the second detection parameter refers to the parameter obtained by detecting the interfering substances in the reaction solution, and the second detection parameter is used to obtain the second interfering substance information in the reaction solution.

[0209] For example, if the second detection parameter is obtained by using an optical analysis technique, then the second detection parameter includes optoelectronic data. In a specific implementation, the detection device includes a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, and the irradiation light forms second outgoing light after irradiating the reaction solution, and the optical signal detector collects the second outgoing light and converts the second outgoing light into second optoelectronic data; among them, the second detection parameter includes the second optoelectronic data. In this implementation, the control device is configured to obtain the second interfering substance information in the reaction solution according to the second optoelectronic data included in the second detection parameter. Further, the optical analysis technique may include PDR technology, and the second optoelectronic data includes PDR optoelectronic data.

[0210] The control device is configured to obtain the first interfering substance information in the sample to be tested according to the first detection parameter; obtain the second interfering substance information in the reaction solution according to the second detection parameter; and determine the type or source of the interfering substances in the reaction solution according to the first interfering substance information and the second interfering substance information.

[0211] The embodiment of the present application also provides a sample analysis method, as Figure 9 shown, this sample analysis method includes steps S91 - S93.

[0212] S91: Obtain the sample to be tested or the pretreatment solution of the sample to be tested for interfering substance detection to obtain the first interfering substance information. Among them, the pretreatment solution is prepared from the sample to be tested and a pretreatment reagent.

[0213] Among them, the interfering substance information of the sample to be tested is obtained through various interfering substance testing methods such as sample to be tested image recognition, serum index test, and optical detection.

[0214] S92: Obtain the optoelectronic data of the reaction solution prepared from the sample to be tested and a reaction reagent, and obtain the second interfering substance information according to the optoelectronic data of the reaction solution. Among them, the optoelectronic data is obtained by collecting the outgoing light of the light source irradiating the reaction solution.

[0215] S93: Determine the type or source of the interferent in the reaction solution based on the first interferent information and the second interferent information; or, correct the optoelectronic data based on the first interferent information and the second interferent information to obtain the test result of the test item.

[0216] In this embodiment, the interferent information of the test sample and the interferent information of the reaction solution can be used for interference detection to obtain accurate interferent information of the reaction solution. Or, the interferent information of the test sample and the interferent information of the reaction solution can also correct the optoelectronic data of the reaction solution, so as to obtain a more accurate test result of the item. For specific descriptions, reference can be made to the relevant content above, which will not be elaborated here.

[0217] The embodiment of the present application also provides a sample analysis method, as Figure 10 shown, this sample analysis method includes steps S101 - S104.

[0218] S101: Perform interference detection on the test sample or the pretreatment solution of the test sample. The pretreatment solution is prepared from the test sample and a pretreatment reagent.

[0219] S102: When the interference detection indicates that there is an interferent in the test sample, process the test sample to remove the interferent in the test sample.

[0220] S103: Prepare a reaction solution from the processed test sample and a reagent, and collect the optoelectronic data of the reaction solution. The optoelectronic data is obtained by collecting the outgoing light of the light source irradiating the reaction solution during the item detection process.

[0221] S104: Determine the test result of the test item based on the optoelectronic data of the reaction solution.

[0222] In the existing item detection process, if it is found that there is an interferent after obtaining the item detection result, the test sample is processed and the item detection process is performed again, resulting in unnecessary repetition and cumbersome of the detection process, reducing the item test efficiency and causing waste of reagents. Compared with the prior art, the embodiment of the present application can detect possible interference before the reaction solution of the test sample is prepared, and perform the item test after excluding the interference, thereby saving reagent costs and improving the item detection efficiency.

[0223] Regarding the above description of the disclosed embodiments, the features described in each embodiment in this specification can be replaced or combined with each other, enabling those skilled in the art to implement or use this application. This document is described with reference to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope of this document. For example, various operation steps and the components used to perform the operation steps can be implemented in different ways according to a specific application or any number of cost functions associated with the operation of the system (e.g., one or more steps can be deleted, modified, or incorporated into other steps).

[0224] The terms "first", "second", etc. in the specification, claims, and above-mentioned drawings of this document are used to distinguish different objects, rather than to describe a specific order. In addition, the terms "comprising" and "having" and any variations thereof are intended to cover non-exclusive inclusion. For example, a process, method, system, product, or device that includes a series of steps or units is not limited to the listed steps or units, but optionally further includes steps or units not listed, or optionally further includes other steps or units inherent to these processes, methods, or devices.

[0225] In addition, as understood by those skilled in the art, the principles herein can be embodied in a computer program product on a computer-readable storage medium that is preloaded with computer-readable program code. Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu-ray discs, etc.), flash memories, and / or the like. These computer program instructions can be loaded onto a general-purpose computer, a special-purpose computer, or other programmable data processing devices to form a machine, such that the instructions executed on the computer or other programmable data processing devices can generate a device for implementing the specified functions. These computer program instructions can also be stored in a computer-readable memory, which can direct the computer or other programmable data processing devices to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a manufactured article, including a device for implementing the specified functions. The computer program instructions can also be loaded onto a computer or other programmable data processing devices, thereby performing a series of operation steps on the computer or other programmable devices to generate a computer-implemented process, such that the instructions executed on the computer or other programmable devices can provide steps for implementing the specified functions.

[0226] The foregoing detailed description has been presented with reference to various embodiments. However, those skilled in the art will recognize that various modifications and alterations can be made without departing from the scope of the present disclosure. Accordingly, the present disclosure is to be considered in an illustrative rather than a restrictive sense, and all such modifications will be included within its scope. Similarly, the advantages, other advantages, and solutions to problems of the various embodiments have been described above. However, benefits, advantages, solutions to problems, and any elements that produce these, or that make them more explicit, should not be construed as critical, required, or essential. As used herein, the term "comprising" and any other variants thereof are non-exclusive inclusions, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but also other elements not expressly listed or inherent to the process, method, system, article, or apparatus. Additionally, the term "coupled" and any other variants thereof as used herein refer to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection, and / or any other connection.

[0227] The above embodiments merely represent several implementation manners, and their descriptions are relatively specific and detailed, but should not be construed as limiting the scope of the invention patent. It should be noted that for those of ordinary skill in the art, without departing from the concept of the present invention, several variations and improvements can be made, and these all fall within the protection scope of the present invention. Therefore, the protection scope of the invention patent should be subject to the appended claims.

Claims

1. A sample analysis system, characterized in that: include: A sample preparation device, the sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent; A detection device, the detection device comprising a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms a first outgoing light after irradiating the pre-treated liquid or at least part of the sample to be tested, and the optical signal detector collects the first outgoing light to obtain first photoelectric data; The irradiation light forms a second outgoing light after irradiating the reaction liquid, and the optical signal detector collects the second outgoing light to obtain second photoelectric data; wherein the pretreatment liquid is prepared by the sample preparation device using at least part of the sample to be tested and the pretreatment reagent; A control device is configured to obtain first interferer information in the sample to be tested based on the first photoelectric data; obtain second interferer information in the reaction liquid and the test results of the test items of the sample to be tested based on the second photoelectric data; and determine the interferer type or interferer source of the reaction liquid based on the first interferer information and the second interferer information.

2. The sample analysis system according to claim 1, characterized in that: The sample preparation device comprises: A sample dispensing mechanism, used for dispensing part of the sample to be tested into the second reaction container and dispensing part of the sample to be tested into the first reaction container; a reagent dispensing mechanism, used for dispensing the pretreatment reagent and the reaction reagent into the second reaction container to form the reaction solution and dispensing the pretreatment reagent into the first reaction container to form the pretreatment solution; A reaction device, wherein the reaction device is provided with at least one reaction position, and the reaction position is used to place the second reaction container; in, The irradiation light irradiates the pretreatment liquid in the first reaction container to form the first outgoing light, and the optical signal detector collects the first outgoing light and converts the first outgoing light into the first photoelectric data; The second output light formed after the irradiation light irradiates the same position of the reaction liquid in the second reaction container includes at least two light signals with different wavelengths, and the light signal detector converts at least two of the light signals into the second photoelectric data; and / or, the second reaction container rotates around the light source assembly, and the light signal detector collects the second output light and converts the second output light into the second photoelectric data during the process of the light source assembly continuously irradiating the second reaction container, and the second photoelectric data includes a signal sequence formed by the relationship between the intensity of at least two light signals of different wavelengths and the collection time.

3. The sample analysis system according to claim 1, wherein: The sample preparation device comprises: A sample dispensing mechanism, used for dispensing at least part of the sample to be tested into a reaction container; A reagent dispensing mechanism, used for dispensing the pretreatment reagent into the reaction container to form the pretreatment liquid, and dispensing the reaction reagent into the pretreatment liquid to form the reaction liquid; A reaction device, wherein the reaction device is provided with at least one reaction position, and the reaction position is used to place the reaction container; in, The irradiation light irradiates the pretreatment liquid in the reaction container to form the first outgoing light, and the optical signal detector collects the first outgoing light and converts the first outgoing light into the first photoelectric data; The second output light generated after the irradiation light irradiates the same position of the reaction liquid in the reaction container includes at least two light signals with different wavelengths, and the light signal detector converts at least two of the light signals into the second photoelectric data; and / or, the reaction container rotates around the light source assembly, and the light signal detector collects the second output light and converts the second output light into the second photoelectric data during the process of the light source assembly continuously irradiating the reaction container, and the second photoelectric data includes a signal sequence formed by the relationship between the intensity of at least two light signals of different wavelengths and the collection time.

4. The sample analysis system according to any one of claims 1 to 3, characterized in that: The irradiation light forms a third outgoing light after irradiating the reaction reagent, and the optical signal detector collects the third outgoing light and converts the third outgoing light into third photoelectric data; the control device is further configured to obtain third interference information in the reaction reagent according to the third photoelectric data; Determining the interferer type or interferer source of the reaction liquid at least based on the first interferer information and the second interferer information includes: determining the interferer source or the interferer type of the reaction liquid based on the first interferer information, the second interferer information and the third interferer information.

5. The sample analysis system according to claim 4, characterized in that: After the reaction reagent is dispensed and before the sample to be tested is dispensed, the optical signal detector collects the third output light.

6. The sample analysis system according to claim 1, wherein: The obtaining the second interference information in the reaction solution according to the second photoelectric data includes: At least one characteristic interference quantity is extracted from the second photoelectric data, and second interference material information in the reaction solution is obtained according to the at least one characteristic interference quantity.

7. The sample analysis system according to claim 1, wherein: The obtaining the second interference information in the reaction solution according to the second photoelectric data includes: The second photoelectric data is input into a preset first machine learning model, and the interference information output by the first machine learning model is obtained as the second interference information in the reaction solution.

8. The sample analysis system according to claim 1, wherein: The first interferer information includes at least one of a signal waveform, an interferer content, and an interferer type; the second interferer information includes at least one of a signal waveform, an interferer content, and an interferer type.

9. The sample analysis system according to claim 8, characterized in that: The first interferer information includes a first signal waveform, and the second interferer information includes a second signal waveform; and determining the interferer type or interferer source of the reaction solution according to the first interferer information and the second interferer information includes: The source of the interferer is determined based on the first signal waveform and the second signal waveform.

10. The sample analysis system according to claim 8, wherein: The first interferer information includes a first interferer content, the second interferer information includes a second interferer content, and determining the interferer type or interferer source of the reaction solution according to the first interferer information and the second interferer information includes: The interferent type is determined based on the first interferent level and the second interferent level.

11. The sample analysis system according to claim 8, characterized in that: The first interferer information includes a first interferer type, the second interferer information includes a second interferer type, and determining the interferer type or interferer source of the reaction solution according to the first interferer information and the second interferer information includes: Based on the first interferent type and the second interferent type, the interferent type is determined.

12. The sample analysis system according to claim 11, characterized in that: The determining the interferer type based on the first interferer type and the second interferer type includes: determining the common interferer type of the first interferer type and the second interferer type as the interferer type; or, If the first interferer type does not include a specific interferer type and the second interferer type includes the specific interferer type, the specific interferer type is excluded from the second interferer type and the remaining second interferer type is used as the interferer type.

13. The sample analysis system according to claim 12, wherein: The test item is creatinine. The first interferor type includes lipemia interference, the second interferor type includes globulin interference and lipemia interference, and determining the common interferor type of the first interferor type and the second interferor type as the interferor type includes: determining the interferor type as lipemia interference; or, The first interferer type does not include lipemia interference, the second interferer type includes globulin interference and lipemia interference, and if the first interferer type does not include a specific interferer type and the second interferer type includes the specific interferer type, excluding the specific interferer type from the second interferer type and taking the remaining second interferer type as the interferer type, includes: determining that the interferer type is globulin interference.

14. The sample analysis system according to claim 12, wherein: The detection item is the creatine kinase item, The first interferor type includes lipemia interference, the second interferor type includes globin interference and lipemia interference, and determining the common interferor type of the first interferor type and the second interferor type as the interferor type includes: determining the interferor type as lipemia interference; or, The first interferer type does not include lipemia interference, the second interferer type includes heparin interference and lipemia interference, and if the first interferer type does not include a specific interferer type and the second interferer type includes the specific interferer type, excluding the specific interferer type from the second interferer type and taking the remaining second interferer type as the interferer type, includes: determining that the interferer type is heparin interference.

15. The sample analysis system according to claim 1, wherein: The obtaining first interference information in the sample to be tested according to the first photoelectric data includes: A serum index test result is obtained according to the first photoelectric data, and the serum index test result is used as the first interference information in the sample to be tested.

16. The sample analysis system according to claim 1, wherein: The step of obtaining the detection result of the detection item in the sample to be tested according to the second photoelectric data includes: The second photoelectric data is corrected according to the type of the interference object or the source of the interference object, and the detection result of the detection item in the sample to be tested is obtained based on the corrected second photoelectric data.

17. The sample analysis system according to claim 16, wherein: The step of correcting the second photoelectric data according to the type of the interference object or the source of the interference object, and obtaining the detection result of the detection item in the sample to be tested based on the corrected second photoelectric data, includes: Determining the photoelectric data corresponding to the detection wavelength of the detection item and the photoelectric data corresponding to the interference wavelength of the interference object in the second photoelectric data; the interference object is determined by the type of the interference object or the source of the interference object; The photoelectric data corresponding to the detection wavelength is corrected according to the photoelectric data corresponding to the interference wavelength, and the detection result of the detection item is obtained based on the corrected photoelectric data corresponding to the detection wavelength.

18. The sample analysis system according to claim 1, wherein: The step of obtaining the detection result of the detection item in the sample to be tested according to the second photoelectric data includes: An initial detection result of the detection item in the sample to be detected is obtained according to the second photoelectric data, and the initial detection result is corrected according to the type of the interferer or the source of the interferer to obtain the detection result of the detection item in the sample to be detected.

19. The sample analysis system according to claim 18, wherein: Obtaining an initial detection result of the detection item in the sample to be tested according to the second photoelectric data, and correcting the initial detection result according to the interference type or the interference source to obtain the detection result of the detection item in the sample to be tested, including: Determining the photoelectric data corresponding to the detection wavelength of the detection item and the photoelectric data corresponding to the interference wavelength of the interference object in the second photoelectric data; the interference object is determined by the type of the interference object or the source of the interference object; Determine the initial detection result according to the photoelectric data corresponding to the detection wavelength; Determining the amount of interference caused by the interference object according to the photoelectric data corresponding to the interference wavelength; The initial detection result is corrected according to the interference amount to obtain the detection result of the detection item.

20. The sample analysis system according to any one of claims 1 to 19, characterized in that: The control device is further used to: output the detection result, and / or output the interference type or the interference source.

21. The sample analysis system according to any one of claims 1 to 19, characterized in that: After determining the type of the interferer or the source of the interferer, the control device is further configured to: If the interferent type or the interferent source indicates the presence of an interferent, the sample to be tested is retested or the sample to be tested is recovered.

22. The sample analysis system according to any one of claims 1 to 19, characterized in that: The first interferent information in the sample to be tested is information about the interferent that causes the sample to be tested to have abnormal properties.

23. A sample analysis system, characterized in that: include: A sample preparation device, the sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent; A detection device, the detection device comprising a light source assembly and an optical signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms a first outgoing light after irradiating a pretreatment liquid or at least a part of the sample to be tested, the optical signal detector collects the first outgoing light to obtain first photoelectric data, the irradiation light forms a second outgoing light after irradiating the reaction liquid, the optical signal detector collects the second outgoing light to obtain second photoelectric data; wherein the pretreatment liquid is prepared by the sample preparation device using at least a part of the sample to be tested and a pretreatment reagent; The control device is configured to obtain first interferent information in the sample to be tested based on the first photoelectric data; obtain second interferent information in the reaction liquid based on the second photoelectric data; correct the second photoelectric data based on the first interferent information and the second interferent information, and obtain the detection result of the detection item of the sample to be tested based on the corrected second photoelectric data.

24. The sample analysis system according to claim 23, characterized in that: The first interferent information in the sample to be tested is information about the interferent that causes the sample to be tested to have abnormal properties.

25. A sample analysis system, characterized in that: include: A sample preparation device, the sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent; A detection device, the detection device comprising a light source assembly and a light signal detector; the light source assembly is used to generate irradiation light, the irradiation light forms an outgoing light after irradiating the reaction liquid, and the light signal detector collects the outgoing light to obtain photoelectric data; An acquisition device, used for acquiring first interfering substance information of the sample to be tested or the pretreatment liquid, wherein the pretreatment liquid is prepared by the sample preparation device using at least part of the sample to be tested and the pretreatment reagent; The control device is configured to obtain second interferer information in the reaction solution according to the photoelectric data, and determine the interferer type or interferer source of the reaction solution according to the first interferer information and the second interferer information.

26. The sample analysis system according to claim 25, characterized in that: The first interferent information in the sample to be tested is information about the interferent that causes the sample to be tested to have abnormal properties.

27. A sample analysis system, characterized in that: include: A sample preparation device, the sample preparation device is used to prepare a reaction solution using at least part of the sample to be tested and a reaction reagent; A detection device, the detection device is used to detect the pretreatment liquid or the sample to be tested to obtain a first detection parameter, and detect the reaction liquid to obtain a second detection parameter; wherein the pretreatment liquid is prepared by the sample preparation device using at least part of the sample to be tested and the pretreatment reagent; The control device is configured to obtain first interferent information in the sample to be tested according to the first detection parameter; obtain second interferent information in the reaction liquid according to the second detection parameter; and determine the interferent type or interferent source of the reaction liquid according to the first interferent information and the second interferent information.

28. The sample analysis system according to claim 27, characterized in that: The detection device includes a light source assembly and a light signal detector; The light source assembly is used to generate irradiation light, and the irradiation light forms a second outgoing light after irradiating the reaction liquid, and the optical signal detector collects the second outgoing light and converts the second outgoing light into second photoelectric data; wherein the second detection parameter includes the second photoelectric data; The control device is configured to obtain second interference information in the reaction solution according to the second photoelectric data included in the second detection parameter.

29. The sample analysis system according to claim 27, characterized in that: The first interferent information in the sample to be tested is information about the interferent that causes the sample to be tested to have abnormal properties.

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