A preparation system and process for calcium dobesilate bulk drug

Abstract

The present invention relates to the technical field of calcium dobesilate preparation and production, and specifically discloses a preparation system and process for calcium dobesilate raw material medicine. The preparation system includes a powder mixing drum and a solid-liquid mixing drum. The powder mixing drum is provided with a raw powder addition hole and a mixed powder discharge hole, the solid-liquid mixing drum is provided with a powder inlet hole, and the solid-liquid mixing drum is coaxially connected to a dual-purpose stirring shaft. The powder mixing drum and the solid-liquid mixing drum are movably connected, the mixed powder discharge hole of the powder mixing drum is connected to a control valve, and the mixed powder discharge hole of the powder mixing drum is located at the powder inlet hole of the solid-liquid mixing drum. A transmission structure is provided at one end of the dual-purpose stirring shaft near the drive motor. The transmission structure is used to transfer kinetic energy generated by the dual-purpose stirring shaft when it rotates to the powder mixing drum to enable it to move. The present invention connects the powder mixing drum and the solid-liquid mixing drum. After mixing, the powder leaves the powder mixing drum and directly enters the solid-liquid mixing drum to contact water, thereby improving production efficiency.

Description

Technical Field

[0001] The invention relates to the technical field of preparation and production of calcium dobesilate, and in particular to a preparation system and process of a calcium dobesilate bulk drug. Background Art

[0002] Calcium dobesilate is a drug that acts on the endothelial cell layer and basal layer of capillary blood vessels. It can regulate and improve the permeability and flexibility of capillaries, increase the resistance of capillary walls, activate the lymphatic circulation system, and can also be used to treat diabetes, etc.

[0003] Currently, the main production process for calcium dobesilate is to first synthesize a crude product and then recrystallize it to produce high-purity calcium dobesilate. The first step in synthesizing the crude product is to mix, dissolve, and filter the various raw materials to remove insoluble impurities. The mixed raw materials are powders, which are mixed in a mixer to allow the powders to intermingle to form a crude product mixture. The white solid crude product is mixed with water, stirred, heated to dissolve, and then hot filtered to remove insoluble matter. The filtrate is then pumped into a crystallizer for crystallization and centrifugation to obtain a wet product, which is then dried to obtain high-purity calcium dobesilate.

[0004] For example, a Chinese patent document with announcement number CN210752424U discloses a mixer for calcium hydroxybenzenesulfonate dispersible tablets, which includes a mixing container and a discharge cover; the mixing container has a mixing chamber inside, a discharge port is opened in the mixing container, a discharge pipe is extended from the outside of the discharge port, a discharge channel is provided in the discharge pipe, and an external thread is provided on the outside of the end of the discharge pipe away from the discharge port; the discharge cover includes a cover body and a plug body, the outer edge of the cover body is protruding toward the discharge pipe and is provided with a threaded portion, the threaded portion is provided with an internal thread, the threaded portion is connected to the outer thread of the discharge pipe, the plug body is inserted into the discharge port through the discharge channel, and a rubber ring is provided on the outer side of the plug body.

[0005] As can be seen from the above, to improve the sealing of the discharge port during the mixing process, a rubber ring is installed on the plug body. When the discharge cap closes the discharge channel, the rubber ring and the inner wall of the discharge channel are tightly abutted. The presence of the rubber ring also increases the friction between the discharge cap and the discharge pipe. The discharge pipe and the discharge cap are threaded together. After the raw materials are mixed, the discharge cap is manually opened, and the discharge port is then positioned below the mixing container, allowing the mixture to fall out. The operator then uses a container or a dedicated transfer device to collect and transport the mixture and then add it to the solid-liquid mixing equipment. The entire process is time-consuming and labor-intensive, affecting production efficiency. Summary of the Invention

[0006] The present invention provides a preparation system and process for a calcium dobesilate bulk drug, aiming to solve the problem in the related art that the operation after mixing the raw materials is complicated and affects the production efficiency.

[0007] In a first aspect, the present invention provides a preparation system for a calcium dobesilate bulk drug, comprising a powder mixing drum and a solid-liquid mixing drum, wherein the powder mixing drum is provided with a raw powder addition hole and a mixed powder discharge hole, the solid-liquid mixing drum is connected to a liquid supply pipe, the solid-liquid mixing drum is provided with a powder inlet hole, the solid-liquid mixing drum is coaxially connected to a dual-purpose stirring shaft, and the solid-liquid mixing drum is provided with a drive motor for driving the dual-purpose stirring shaft to rotate; the powder mixing drum and the solid-liquid mixing drum are movably connected, the mixed powder discharge hole of the powder mixing drum is connected to a control valve, the control valve is used to control the opening and closing of the mixed powder discharge hole, the mixed powder discharge hole of the powder mixing drum is located at the powder inlet hole of the solid-liquid mixing drum and the two are connected, the dual-purpose stirring shaft protrudes from the end of the solid-liquid mixing drum at one end close to the drive motor, and the end of the dual-purpose stirring shaft is provided with a transmission structure, the transmission structure is used to transfer kinetic energy generated by the rotation of the dual-purpose stirring shaft to the powder mixing drum to enable it to move.

[0008] The effect is that the powder mixing drum is responsible for the preliminary mixing of various powder raw materials, the solid-liquid mixing drum is used to add the mixed powder into water and dissolve it, the opening and closing of the powder mixing discharge hole of the powder mixing drum is controlled by the control valve, and when the mixing is completed, the control valve is opened, and the powder in the powder mixing drum naturally falls and leaves the powder mixing drum. At the same time, since the powder mixing discharge hole is located at the powder inlet hole, the powder falling from the powder mixing drum enters the solid-liquid mixing drum and contacts with water and dissolves, without manual transfer, thereby improving the working efficiency; at the same time, the dual-purpose stirring shaft working on the solid-liquid mixing drum transfers kinetic energy to the powder mixing drum through the transmission structure when rotating, as one of the working powers to make the powder mixing drum active, so that powder mixing and powder dissolution can be carried out simultaneously, further improving the working efficiency from powder mixing to dissolution.

[0009] Preferably, the powder mixing discharge hole of the powder mixing cylinder is rotatably connected and communicated with a connecting bottom hopper, the control valve is located in the connecting bottom hopper, and the connecting bottom hopper is connected to the solid-liquid mixing cylinder; the transmission structure is a transmission gear, the transmission gear and the dual-purpose stirring shaft are relatively fixed, the axis of the transmission gear is parallel to the axis of the dual-purpose stirring shaft, and a friction drive ring is coaxially fixedly connected to the powder mixing cylinder, and the outer edge of the friction drive ring abuts against the serrations of the transmission gear.

[0010] The effect is that when the transmission gear rotates with the dual-purpose stirring shaft, torque is applied to the friction drive ring through friction force, thereby driving the powder mixing drum to rotate, and the powder inside the powder mixing drum also moves accordingly for mixing.

[0011] Preferably, the connecting bottom hopper is located at the bottom of the powder mixing drum and the two are coaxial, the raw powder adding hole is located at the top of the powder mixing drum, a connecting cover is coaxially rotatably connected on the powder mixing drum at the raw powder adding hole, a powder pipe joint is fixedly connected to the connecting cover, a movable support frame is fixedly connected to the solid-liquid mixing drum, the connecting cover and the movable support frame are movably connected, the connecting bottom hopper and the hole wall of the powder inlet hole are movably connected, and the abutment force of the transmission gear on the friction drive ring changes periodically.

[0012] The effect is that the contact force of the transmission gear on the friction drive ring is sometimes large and sometimes small, so the powder mixing cylinder, the connecting cover and the connecting bottom hopper will move due to the dynamic force conditions, thereby improving the mixing efficiency of the powder in the powder mixing cylinder.

[0013] Preferably, the profile of the transmission gear is non-circular, or the profile of the transmission gear is circular and the transmission gear and the dual-purpose stirring shaft are eccentrically arranged relative to each other.

[0014] The effect is that: when the outline of the transmission gear is circular and is eccentrically set relative to the dual-purpose stirring shaft, during the process of the dual-purpose stirring shaft driving the transmission gear to rotate, the edge position of the transmission gear toward each powder mixing barrel changes periodically, and a periodic driving effect is produced on each powder mixing barrel, thereby enabling each powder mixing barrel to shake periodically; when the outline of the transmission gear is non-circular, similar to the transmission gear with a circular outline, the transmission gear also produces a periodic driving effect on the powder mixing barrel, except that the swing amplitude and period are changed.

[0015] Preferably, the connecting bottom bucket and the solid-liquid mixing drum are hinged, the hinge axis is perpendicular to the radial direction of the solid-liquid mixing drum, the connecting cover is slidably connected relative to the movable support frame, and the sliding direction is an arc with the hinge axis of the connecting bottom bucket as the center. A support spring is connected between the movable support frame and the connecting cover, and the direction of the elastic force applied by the support spring to the connecting cover is toward the dual-purpose stirring shaft.

[0016] The resulting effect is that, because the axis of the articulated shaft is perpendicular to the radial direction of the solid-liquid mixing drum, the powder mixing drum, when subjected to periodically varying thrust, swings back and forth toward and away from the dual-purpose stirring shaft, further improving the mixing efficiency of the powder materials within the drum. During this swinging motion, the friction drive ring on the side facing the transfer gear experiences height changes. Since torque is transmitted between the friction drive ring and the transfer gear via contact friction, the mating precision requirements are minimal. Therefore, it is sufficient to ensure that the friction drive ring maintains effective contact with the teeth of the transfer gear during this height change.

[0017] Preferably, an elastic isolation cloth is fixedly connected to the solid-liquid mixing drum at the powder inlet, and the elastic isolation cloth is fixedly connected to the connecting bottom hopper.

[0018] The effect is that the size of the powder inlet hole must ensure that it does not block the swinging movement of the connecting bottom hopper, that is, under normal conditions, there are relatively large pores in the outline of the powder inlet hole. The elastic isolation cloth can seal the pores of the powder inlet hole without affecting the swinging of the connecting bottom hopper, thereby reducing the negative impact of external factors on the inner cavity space of the solid-liquid mixing drum.

[0019] Preferably, there are multiple powder mixing drums, and the multiple powder mixing drums are arranged in a circumferential array on the dual-purpose stirring shaft. The deflection angle range of the axis of the connecting bottom hopper relative to the axis of the solid-liquid mixing drum is 0°-33°.

[0020] Preferably, an auxiliary material-prying rod is slidably provided on the connecting cover, and the sliding direction is parallel to the axis of the powder mixing barrel. One end of the auxiliary material-prying rod extends into the powder mixing barrel, and the side wall of the auxiliary material-prying rod located in the powder mixing barrel is fixedly connected with a material-prying paddle. A control component for driving the auxiliary material-prying rod to slide is provided between the connecting cover and the movable support frame.

[0021] The effect is that under the action of the control component, the auxiliary material-moving rod moves back and forth axially relative to the powder mixing barrel, and each material-moving paddle continuously stirs the powder in the powder mixing barrel, thereby improving the powder mixing efficiency therein.

[0022] Preferably, the control component includes a reciprocating spring, a feedback roller and a guide wave bar, the reciprocating spring is connected between the auxiliary material removing rod and the connecting cover, the extension and contraction direction of the reciprocating spring is parallel to the sliding direction of the auxiliary material removing rod, the guide wave bar is fixedly connected to the movable support frame, the length direction of the guide wave bar is parallel to the sliding direction of the connecting cover relative to the movable support frame, the feedback roller is rotatably set on the auxiliary material removing rod and is located outside the powder mixing barrel, and the wheel surface of the feedback roller rolls and abuts against the curved surface of the guide wave bar.

[0023] The effect is that: under the elastic force of the reciprocating spring, the auxiliary material-pickup rod always has a tendency to move close to the connecting bottom bucket, and the wheel surface of the feedback roller always sticks to the curved surface of the guide wave bar. During the swinging of the powder mixing drum, the wheel surface of the feedback roller rolls along the curved surface of the guide wave bar, and the auxiliary material-pickup rod moves back and forth axially relative to the powder mixing drum, so that the material-pickup slurry plate realizes the material-pickup action.

[0024] On the other hand, a production process of calcium dobesilate bulk drug using the above-mentioned calcium dobesilate bulk drug preparation system of the present invention comprises the following steps in sequence:

[0025] S1: Powder mixing: add powder raw materials into each powder mixing drum in turn, start the drive motor, and the powder mixing drum rotates and swings back and forth relative to the solid-liquid mixing drum;

[0026] S2: Powder dissolves. Water with a temperature of 50-60°C is added to the solid-liquid mixing drum through the liquid supply pipe. The control valve is opened, and the powder in the powder mixing drum falls into the solid-liquid mixing drum for dissolution.

[0027] S3: Filtration: Filter the mixture in the solid-liquid mixing drum using physical methods to separate insoluble matter from the liquid;

[0028] S4: Crystallization: The liquid in the solid-liquid mixing drum is extracted and placed into the crystallization tank for crystallization treatment;

[0029] In S2, the control valve enables the dual-purpose stirring shaft to rotate continuously when the powder mixture discharge hole is open, and the rotation speed is lower than the rotation speed of the dual-purpose stirring shaft when the control valve enables the powder mixture discharge hole to be closed.

[0030] The effect is that after the dual-purpose stirring shaft is started and rotated, all powder mixing drums move relative to the solid-liquid stirring drum at the same time. When the mixing degree of materials in a certain powder mixing drum reaches the requirement, the powder mixing discharge hole can be opened to allow the powder to fall into the solid-liquid stirring drum, directly contact and dissolve with the water in the solid-liquid stirring drum. Each powder mixing drum is opened one by one to release the powder. The specific surface area of the powder particles when in contact with water is large, which is conducive to increasing the dissolution speed. At the same time, the dual-purpose stirring shaft keeps rotating when the powder mixing discharge hole is opened, and the powder falling angle of the connecting bottom hopper is constantly changing, thereby improving the uniformity of the powder landing point distribution.

[0031] By adopting the above technical solution, the beneficial effects of the present invention are:

[0032] The present invention directly connects the powder mixing drum and the solid-liquid mixing drum, opens the powder mixing discharge hole after the powder mixing is completed, and the powder leaving the powder mixing drum directly falls into the solid-liquid mixing drum to contact with water, without the need for manual operation or transportation. The rotation of the dual-purpose stirring shaft not only improves the dissolution efficiency in the solid-liquid mixing drum, but also generates active power for the powder mixing drum. The powder mixing and powder dissolution are carried out simultaneously, so the preparation process has the characteristics of high efficiency and high continuity. At the same time, the powder in the powder mixing drum enters the solid-liquid mixing drum in batches, and the instantaneous rate of solid-liquid mixing is also relatively fast. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 The figure is a schematic cross-sectional view of the overall structure of a preparation system of calcium dobesilate bulk drug in an embodiment of the present invention.

[0034] Figure 2 1 is a schematic top view of a system for preparing a calcium dobesilate bulk drug in an embodiment of the present invention.

[0035] Figure 3 yes Figure 1 A partial enlarged view of part A in the middle.

[0036] Figure 4 It is a structural schematic diagram showing the swing angle range of the powder mixing drum in an embodiment of the present invention.

[0037] Figure 5 It is a structural diagram illustrating the working principle of the control component in an embodiment of the present invention.

[0038] Figure 6 It is a structural schematic diagram of the connection cover and the auxiliary material removing rod in an embodiment of the present invention.

[0039] Figure 7 The present invention is a process flow chart showing the preparation process of calcium dobesilate raw material.

[0040] Reference numerals:

[0041] 1. Solid-liquid mixing drum; 11. Dual-purpose stirring shaft; 12. Driving motor; 13. Liquid supply pipe; 14. Powder inlet hole; 15. Elastic isolation cloth; 2. Movable support frame; 21. Support spring; 22. Guide arc groove; 3. Powder mixing drum; 31. Raw powder adding hole; 32. Mixed powder discharge hole; 33. Connecting bottom hopper; 331. Reciprocating hinged shaft; 34. Connecting cover; 341. Powder pipe joint; 342. Guide slide pin; 35. Auxiliary material discharging rod; 351. Material discharging paddle; 36. Friction drive ring; 4. Control assembly; 41. Reciprocating spring; 42. Feedback roller; 43. Guide wave bar; 5. Transmission gear. DETAILED DESCRIPTION

[0042] The following combination Figures 1 to 7 The invention describes a preparation system and process for a calcium dobesilate bulk drug.

[0043] This embodiment discloses a preparation system of calcium dobesilate bulk drug, such as Figure 1 and Figure 2 As shown, it includes a powder mixing drum 3 and a solid-liquid mixing drum 1. The powder mixing drum 3 is used to mix a variety of powder raw materials to form a crude product, and then the crude product mixture enters the solid-liquid mixing drum 1 and contacts with water at a specific temperature for dissolution. Both are cylindrical; the axis of the solid-liquid mixing drum 1 is a vertical straight line, and a dual-purpose stirring shaft 11 is coaxially connected to the solid-liquid mixing drum 1. A drive motor 12 for driving the dual-purpose stirring shaft 11 to rotate is installed on the solid-liquid mixing drum 1, and the output shaft of the drive motor 12 is coaxially connected to the dual-purpose stirring shaft 11.

[0044] like Figure 1 、 Figure 2 and Figure 3 As shown, the powder mixing drum 3 is movably mounted above the solid-liquid mixing drum 1. In this embodiment, there are four powder mixing drums 3, arranged in a circumferential array around the dual-purpose stirring shaft 11. One end of the powder mixing drum 3 is provided with a raw powder addition port 31, and the other end is provided with a mixed powder discharge port 32. A connecting cap 34 is coaxially connected to the raw powder addition port 31, while a connecting hopper 33 is coaxially connected to the mixed powder discharge port 32. A powder pipe connector 341 is fixedly connected to the connecting cap 34. The internal passageway of the powder pipe connector 341 extends into and communicates with the interior of the powder mixing drum 3. The powder pipe connector 341 is removably connected to the supply line for the powder raw material, allowing the operator to add powder raw material to the powder mixing drum 3 through the powder pipe connector 341. A control valve (not shown) is located within the connecting hopper 33. In this embodiment, the control valve is a solenoid butterfly valve, which controls the flow of the connecting hopper 33, thereby controlling the opening or closing of the mixed powder discharge port 32. A powder inlet hole 14 is provided on the top of the solid-liquid mixing drum 1 . The number of the powder inlet holes 14 is the same as the number of the powder mixing drums 3 and the two correspond one to one.

[0045] like Figure 3 、 Figure 4 and Figure 5 As shown, a reciprocating hinge shaft 331 is fixedly connected to the connecting bottom hopper 33, and the reciprocating hinge shaft 331 is horizontally inserted into the hole wall of the powder inlet hole 14. The connecting bottom hopper 33 is hinged to the solid-liquid mixing drum 1 through the reciprocating hinge shaft 331. The axis of the reciprocating hinge shaft 331 is perpendicular to the radial direction of the solid-liquid mixing drum 1, that is, the powder mixing drum 3 and the connecting cover 34 on the connecting bottom hopper 33 can swing close to or away from the axis of the solid-liquid mixing drum 1. The solid-liquid mixing drum 1 is fixedly connected to a movable support frame 2, and a guide arc groove 22 is provided on the movable support frame 2. The trajectory of the guide arc groove 22 is an arc with the hinge axis of the connecting bottom bucket 33 as the center. A guide slide pin 342 is fixedly connected to the connecting cover 34, and the guide slide pin 342 is inserted into the guide arc groove 22. During the swinging of the connecting bottom bucket 33 relative to the solid-liquid mixing drum 1, the guide slide pin 342 slides in the guide arc groove 22, that is, the connecting cover 34 is slidably arranged along the movable support frame 2 through the guide slide pin 342, thereby improving the overall stability of the powder mixing drum 3 and the connecting cover 34 when they swing with the connecting bottom bucket 33. A support spring 21 is connected between the movable support frame 2 and the connecting cover 34. One end of the support spring 21 is fixedly connected to the movable support frame 2, and the other end is fixedly connected to the connecting cover 34. The support spring 21 is located on the side of the connecting cover 34 away from the dual-purpose stirring shaft 11. The support spring 21 always applies thrust to the connecting cover 34. When the connecting cover 34 is in the position closest to the dual-purpose stirring shaft 11, the axis of the powder mixing drum 3 is parallel to the axis of the solid-liquid mixing drum 1.

[0046] like Figure 1 、 Figure 3 and Figure 4As shown, the end of the dual-purpose stirring shaft 11, near the drive motor 12, extends a distance from the end of the solid-liquid mixing drum 1. This portion of the dual-purpose stirring shaft 11 is equipped with a transmission structure for transmitting the kinetic energy generated by the rotation of the dual-purpose stirring shaft 11 to the powder mixing drum 3, causing it to swing. The transmission structure is a transmission gear 5. The transmission gear 5 and the dual-purpose stirring shaft 11 are relatively fixed, and the axis of the transmission gear 5 is parallel to the axis of the dual-purpose stirring shaft 11. A friction drive ring 36 made of rubber is coaxially fixed to the powder mixing drum 3. The outer edge of the friction drive ring 36 abuts the serrations of the transmission gear 5. As the transmission gear 5 rotates with the dual-purpose stirring shaft 11, the friction force exerts torque on the friction drive ring 36, thereby driving the powder mixing drum 3 to rotate.

[0047] like Figure 2 、 Figure 3 and Figure 4 As shown, the axial length of the friction drive ring 36 is greater than the axial thickness of the transfer gear 5, and in this embodiment, the profile of the transfer gear 5 is circular and the transfer gear 5 and the dual-purpose stirring shaft 11 are relatively eccentrically arranged, so that the edge of the transfer gear 5 has a proximal point and a distal point. For a certain position of the powder mixing drum 3, during the rotation of the transfer gear 5, the distance between the serrations of the transfer gear 5 and the dual-purpose stirring shaft 11 changes periodically, that is, the magnitude of the abutment force of the transfer gear 5 on the friction drive ring 36 changes periodically. Under the influence of this change, the transfer gear 5 pushes the powder mixing drum 3 to swing back and forth. When the friction drive ring 36 contacts the serrations near the center of the transmission gear 5, the axis of the powder mixing drum 3 is vertical. When the friction drive ring 36 contacts the serrations at the distal point of the transmission gear 5, the axis of the powder mixing drum 3 deflects by 33° relative to the axis of the solid-liquid mixing drum 1. Throughout the range of the powder mixing drum 3's oscillation, the surface of the friction drive ring 36 consistently contacts the edge of the transmission gear 5. In this embodiment, the outer diameter of the powder mixing drum 3 is 200 mm. At both end-of-travel positions, the maximum vertical lift distance of the friction drive ring 36 toward the transmission gear 5 is 47 mm. Each time the transmission gear 5 rotates one full revolution, each powder mixing drum 3 oscillates back and forth for one full cycle. Accordingly, when the transmission gear 5 is coaxially connected to the dual-purpose stirring shaft 11 and the transmission gear 5 has a non-circular profile, the transmission structure can also achieve the aforementioned function. Specifically, when the transmission gear 5 is coaxially fixedly connected to the dual-purpose stirring shaft 11, it can be an elliptical gear, a square gear, a Lello triangular gear, or the like. These are not illustrated or described here.

[0048] like Figure 3As shown, the size of the opening of the powder inlet hole 14 needs to ensure that it does not hinder the swinging movement of the connecting bottom hopper 33. In order to improve the sealing of the internal space of the solid-liquid mixing drum 1, an elastic isolation cloth 15 is fixedly connected to the solid-liquid mixing drum 1 and located at the powder inlet hole 14. The elastic isolation cloth 15 is fixedly connected to the connecting bottom hopper 33, and the connection point between the elastic isolation cloth 15 and the connecting bottom hopper 33 is located below the reciprocating hinge shaft 331; during the swinging process of the connecting bottom hopper 33, the elastic isolation cloth 15 always keeps the powder inlet hole 14 closed. In this embodiment, the elastic isolation cloth 15 is made of a rubber film with a thickness of 2 mm.

[0049] like Figure 5 and Figure 6 As shown, an auxiliary material-prying rod 35 is slidably provided on the connecting cover 34, and its sliding direction is parallel to the axis of the powder mixing barrel 3. One end of the auxiliary material-prying rod 35 extends into the powder mixing barrel 3, and the other end is located outside the powder mixing barrel 3. A plurality of material-prying paddles 351 are fixedly connected to the side wall of the portion of the auxiliary material-prying rod 35 located in the powder mixing barrel 3. A control assembly 4 for driving the auxiliary material-prying rod 35 to slide is provided between the connecting cover 34 and the movable support frame 2. The control assembly 4 includes a reciprocating spring 41, a feedback roller 42, and a guide wave bar 43. One end of the reciprocating spring 41 is fixedly connected to the connecting cover 34, and the other end is fixedly connected to the auxiliary material-prying rod 35. The reciprocating spring 41 has a telescopic direction parallel to the sliding direction of the auxiliary material-prying rod 35. The guide wave strip 43 is fixedly connected to the upper side of the movable support frame 2. The length direction of the guide wave strip 43 is also an arc with the hinge axis of the connecting bottom hopper 33 as the center, and is parallel to the length direction of the guide arc groove 22. The upper surface of the guide wave strip 43 is a continuously undulating curved surface shaped like a wave line; the feedback roller 42 is rotatably arranged on the auxiliary material-pickup rod 35 and is located outside the powder mixing drum 3, and its rotation axis is parallel to the hinge axis of the connecting bottom hopper 33; under the elastic force of the reciprocating spring 41, the auxiliary material-pickup rod 35 always has a tendency to move close to the connecting bottom hopper 33, and the wheel surface of the feedback roller 42 always adheres to the curved surface of the guide wave strip 43. During the swinging process of the powder mixing drum 3, the wheel surface of the feedback roller 42 rolls along the curved surface of the guide wave strip 43, and the auxiliary material-pickup rod 35 moves back and forth axially relative to the powder mixing drum 3. Each material-pickup paddle 351 continuously pokes the powder in the powder mixing drum 3, thereby improving the powder mixing efficiency therein.

[0050] like Figure 7 As shown, this embodiment also discloses a production process of calcium dobesilate API using the above-mentioned calcium dobesilate API preparation system, which comprises the following steps in sequence:

[0051] S1: Powder mixing: Add the required various powder raw materials into each powder mixing drum 3 in turn, start the drive motor 12, and the powder mixing drum 3 rotates. At the same time, under the thrust of the transmission gear 5, each powder mixing drum 3 swings back and forth relative to the solid-liquid mixing drum 1;

[0052] S2: Powder dissolves. Water at a temperature of 50°C-60°C is added to the solid-liquid mixing drum 1 through the liquid supply pipe 13. The control valve is opened, and the powders in each powder mixing drum 3 fall into the solid-liquid mixing drum 1 in turn. After contact with the water, the powders are mixed and dissolved. The discharge order of each powder mixing drum 3 is consistent with the powder addition order in S1, thereby ensuring that the powders in each powder mixing drum 3 are mixed relatively evenly and fully.

[0053] S3: Filtration; filtering the mixture in the solid-liquid mixing drum 1 by a physical method (such as centrifugation, filter method, etc.) to separate the insoluble matter from the liquid;

[0054] S4: Crystallization: The liquid in the solid-liquid mixing drum 1 is pumped out into a crystallization tank for crystallization treatment.

[0055] It should be noted that when the control valve in S2 opens the powder discharge hole 32, the dual-purpose stirring shaft 11 continues to rotate, and the speed of the dual-purpose stirring shaft 11 at this time is lower than the speed of the dual-purpose stirring shaft 11 when the control valve closes the powder discharge hole 32. In this embodiment, when the powder discharge hole 32 of any powder mixing drum 3 is open, the speed of the dual-purpose stirring shaft 11 is adjusted to 38 r / min, that is, the oscillation frequency of the powder mixing drum 3 is 38 times per minute. When the powder discharge holes 32 of all powder mixing drums 3 are closed, the speed of the dual-purpose stirring shaft 11 is adjusted to 75 r / min, that is, the oscillation frequency of the powder mixing drum 3 is 75 times per minute. When the powder discharge hole 32 is closed, it is necessary to ensure that the continuous reciprocating oscillation time of each powder mixing drum 3 is at least 100 seconds.

[0056] Although the embodiments of the present invention have been shown and described above, it can be understood that the textual descriptions and drawings of the above embodiments are exemplary and are intended to be used to explain the inventive concept of the present invention. They cannot be understood as limitations on the present invention. Those skilled in the art can change, modify, replace and modify the above embodiments within the scope of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without making any creative work shall fall within the scope of protection of the present invention.

Claims

1. A system for preparing a calcium dobesilate bulk drug, comprising a powder mixing drum and a solid-liquid mixing drum, the powder mixing drum having a raw powder addition port and a mixed powder discharge port, the solid-liquid mixing drum connected to a liquid supply pipe, the solid-liquid mixing drum having a powder inlet port, the solid-liquid mixing drum having a coaxially rotatable dual-purpose stirring shaft, and the solid-liquid mixing drum being provided with a drive motor for driving the dual-purpose stirring shaft; It is characterized by: The powder mixing drum and the solid-liquid mixing drum are movably connected, a control valve is connected to the powder mixing discharge hole of the powder mixing drum, and the control valve is used to control the opening and closing of the powder mixing discharge hole. The powder mixing discharge hole of the powder mixing drum is located at the powder inlet hole of the solid-liquid mixing drum and the two are connected. The end of the dual-purpose stirring shaft close to the driving motor extends from the end of the solid-liquid mixing drum, and the end of the dual-purpose stirring shaft is provided with a transmission structure, which is used to transmit the kinetic energy generated when the dual-purpose stirring shaft rotates to the powder mixing drum to enable it to move; The powder mixing cylinder is rotatably connected to and communicated with a connecting bottom hopper at the powder mixing discharge hole, the control valve is located in the connecting bottom hopper, and the connecting bottom hopper is connected to the solid-liquid mixing cylinder; The transmission structure is a transmission gear, the transmission gear and the dual-purpose stirring shaft are relatively fixed, the axis of the transmission gear is parallel to the axis of the dual-purpose stirring shaft, and a friction drive ring is coaxially fixedly connected to the powder mixing cylinder, and the outer edge of the friction drive ring abuts against the serrations of the transmission gear; The connecting bottom hopper is located at the bottom of the powder mixing drum and the two are coaxial. The raw powder adding hole is located at the top of the powder mixing drum. A connecting cover is coaxially connected to the powder mixing drum and rotatably connected to the raw powder adding hole. A powder pipe joint is fixedly connected to the connecting cover. A movable support frame is fixedly connected to the solid-liquid mixing drum. The connecting cover and the movable support frame are movably connected. The connecting bottom hopper is movably connected to the hole wall of the powder inlet hole. The abutment force of the transmission gear on the friction drive ring changes periodically. The profile of the transmission gear is non-circular, or the profile of the transmission gear is circular and the transmission gear and the dual-purpose stirring shaft are eccentrically arranged relative to each other; The connecting bottom bucket and the solid-liquid mixing drum are hinged, and the hinge axis is perpendicular to the radial direction of the solid-liquid mixing drum. The connecting cover is slidably connected relative to the movable support frame, and the sliding direction is an arc with the hinge axis of the connecting bottom bucket as the center. A support spring is connected between the movable support frame and the connecting cover, and the direction of the elastic force applied by the support spring to the connecting cover is toward the dual-purpose stirring shaft.

2. A preparation system for calcium dobesilate bulk drug according to claim 1, characterized in that, An elastic isolation cloth is fixedly connected to the solid-liquid mixing drum and located at the powder inlet hole, and the elastic isolation cloth is fixedly connected to the connecting bottom bucket.

3. A preparation system for calcium dobesilate bulk drug according to claim 2, characterized in that, There are multiple powder mixing drums, which are arranged in a circumferential array on the dual-purpose stirring shaft. The deflection angle range of the axis of the connecting bottom bucket relative to the axis of the solid-liquid mixing drum is 0°-33°.

4. A system for preparing a calcium dobesilate bulk drug according to any one of claims 1 to 3, characterized in that: An auxiliary material-prying rod is slidingly provided on the connecting cover, and the sliding direction is parallel to the axis of the powder mixing barrel. One end of the auxiliary material-prying rod extends into the powder mixing barrel, and the side wall of the auxiliary material-prying rod located in the powder mixing barrel is fixedly connected with a material-prying paddle. A control component for driving the auxiliary material-prying rod to slide is provided between the connecting cover and the movable support frame.

5. A preparation system for calcium dobesilate bulk drug according to claim 4, characterized in that, The control component includes a reciprocating spring, a feedback roller and a guide wave bar. The reciprocating spring is connected between the auxiliary material removing rod and the connecting cover. The extension and contraction direction of the reciprocating spring is parallel to the sliding direction of the auxiliary material removing rod. The guide wave bar is fixedly connected to the movable support frame. The length direction of the guide wave bar is parallel to the sliding direction of the connecting cover relative to the movable support frame. The feedback roller is rotatably set on the auxiliary material removing rod and is located outside the powder mixing barrel. The wheel surface of the feedback roller rolls and abuts against the curved surface of the guide wave bar.

6. A process for producing a calcium dobesilate bulk drug using the calcium dobesilate bulk drug preparation system according to claim 3, characterized in that: The steps are as follows: S1: Powder mixing: add powder raw materials into each powder mixing drum in turn, start the drive motor, and the powder mixing drum rotates and swings back and forth relative to the solid-liquid mixing drum; S2: Powder dissolves. Water with a temperature of 50-60°C is added to the solid-liquid mixing drum through the liquid supply pipe. The control valve is opened, and the powder in the powder mixing drum falls into the solid-liquid mixing drum for dissolution. S3: Filtration: Filter the mixture in the solid-liquid mixing drum using physical methods to separate insoluble matter from the liquid; S4: Crystallization: The liquid in the solid-liquid mixing drum is extracted and placed into the crystallization tank for crystallization treatment; In S2, the control valve enables the dual-purpose stirring shaft to rotate continuously when the powder mixture discharge hole is open, and the rotation speed is lower than the rotation speed of the dual-purpose stirring shaft when the control valve enables the powder mixture discharge hole to be closed.

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