Sample analyzer and blending control method

Abstract

The embodiment of the invention provides a sample analyzer and a uniform mixing control method. The uniform mixing control method comprises the following steps: controlling a scheduling device of the sample analyzer to schedule a target reagent container from a reagent storage position to a liquid absorption position; a dispensing device of the sample analyzer is controlled to carry out liquid suction operation on the target reagent container located at the liquid suction level so as to suck a reagent carried in the target reagent container, and the target reagent container at least comprises a magnetic bead reagent container used for carrying a magnetic bead reagent; after the liquid suction operation is executed, controlling a dispatching device of the sample analyzer to dispatch the target reagent container at the liquid suction level to the corresponding reagent storage position; wherein after the target reagent container is dispatched to the liquid suction level and before the target reagent container is dispatched to the corresponding reagent storage position, the method further comprises the step of controlling the sample analyzer to uniformly mix the magnetic bead reagent containers.

Description

Technical Field

[0001] This application relates to the technical field of medical devices, and particularly to a sample analyzer and a mixing control method. Background Art

[0002] Taking an immunoassay analyzer as an example of a sample analyzer, this is a type of highly sensitive and highly specific analytical instrument. In clinical laboratories, it is often used to detect various analytical indicators in blood, urine, or other body fluids. Traditional immunoassay analyzers have various working principles, including chemiluminescence method, electrochemiluminescence method, etc.

[0003] Taking a heterogeneous chemiluminescence immunoassay analyzer as an example, its main working principle is as follows: When a certain component in a sample needs to be measured, the corresponding antibody / antigen can be coated on magnetic beads to form a magnetic bead reagent, and a specific label can be labeled on the antibody to form a labeled reagent. During the test process, the sample to be tested is mixed with target reagents such as the magnetic bead reagent and the labeled reagent to form a reaction solution, and incubated under certain conditions to form a reaction complex. Then, through magnetic separation technology, impurities in the reaction system are removed. Finally, a substrate is added, and the substrate reacts with the label on the reaction complex to emit light, and then the detection result is obtained through photometry. Among them, the magnetic bead reagent in the immunoassay analyzer is prone to magnetic bead deposition under static storage conditions. The magnetic bead density at the bottom is significantly greater than that at the upper layer, and the magnetic beads and the reagent solution are in a non-uniform state. When a part of the magnetic bead reagent is aspirated for immunoassay in this state, it is easy to cause the density of the aspirated magnetic beads to be too large or too small, thereby causing the detection result to deviate from the true value and affecting the accuracy and reliability of the detection result.

[0004] Therefore, how to improve the mixing effect of the magnetic bead reagent to improve the accuracy and reliability of the detection result is particularly important. Summary of the Invention

[0005] The main purpose of the embodiments of this application is to provide a sample analyzer and a mixing control method, aiming to improve the mixing effect of the magnetic bead reagent to improve the accuracy and reliability of the detection result.

[0006] In a first aspect, the embodiments of this application provide a sample analyzer, including:

[0007] A reagent storage bin, including a plurality of reagent storage positions for placing reagent containers, the plurality of reagent storage positions are arranged along a first direction, and at least two of the reagent storage positions are stacked along a second direction different from the first direction;

[0008] A dispensing device for dispensing samples and / or reagents;

[0009] A reaction device is provided with at least one reaction position for placing a reaction vessel, the reaction vessel being used to receive the samples and reagents dispensed by the dispensing device so that the samples and the reagents are mixed to form a reaction solution, and the reagents at least include magnetic bead reagents;

[0010] A first mixing device for performing a mixing operation;

[0011] A scheduling device for performing a scheduling operation; and

[0012] A controller is at least communicatively connected to the dispensing device and the scheduling device and is configured to:

[0013] Control the scheduling device to schedule a target reagent container from the reagent storage position to the liquid suction position;

[0014] Control the dispensing device to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying the magnetic bead reagent;

[0015] After the liquid suction operation is completed, control the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position;

[0016] Wherein, the controller is further configured to: after scheduling the target reagent container to the liquid suction position and before scheduling the target reagent container to the corresponding reagent storage position, control the first mixing device to mix the magnetic bead reagent container.

[0017] In a second aspect, an embodiment of the present application further provides a sample analyzer, including:

[0018] A reagent storage bin includes a plurality of reagent storage positions for placing reagent containers, the plurality of reagent storage positions are arranged along a first direction, and at least two of the reagent storage positions are stacked along a second direction different from the first direction;

[0019] A dispensing device for dispensing samples and / or reagents;

[0020] A reaction device is provided with at least one reaction position for placing a reaction vessel, the reaction vessel being used to receive the samples and reagents dispensed by the dispensing device so that the samples and the reagents are mixed to form a reaction solution, and the reagents at least include magnetic bead reagents;

[0021] A scheduling device for performing a scheduling operation;

[0022] A first mixing device for performing a mixing operation, and

[0023] A controller, which is at least communicatively connected to the dispensing device, the scheduling device, and the first mixing device, and is configured to:

[0024] Control the scheduling device to schedule a target reagent container from the reagent storage position to the liquid suction position;

[0025] Control the reagent dispensing mechanism to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying the magnetic bead reagent;

[0026] After the liquid suction operation is completed, control the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position;

[0027] Wherein, the controller is further configured to: during the process of scheduling the target reagent container from the reagent storage position to the liquid suction position, control the first mixing device to mix the magnetic bead reagent container.

[0028] In a second aspect, an embodiment of the present application further provides a mixing control method, which is applied to a sample analyzer, and the method includes:

[0029] Control the scheduling device of the sample analyzer to schedule a target reagent container from the reagent storage position to the liquid suction position;

[0030] Control the dispensing device of the sample analyzer to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying the magnetic bead reagent;

[0031] After the liquid suction operation is completed, control the scheduling device of the sample analyzer to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position;

[0032] Wherein, after scheduling the target reagent container to the liquid suction position and before scheduling the target reagent container to the corresponding reagent storage position, the method further includes: controlling the sample analyzer to mix the magnetic bead reagent container.

[0033] As can be seen from the technical solution provided by the present application above, the sample analyzer arranges and stacks reagent containers through a reagent storage bin, so that more reagent containers can be stored in a three-dimensional space. During the reagent dispensing process, first, the target reagent container in the reagent containers is scheduled to the liquid suction position, and the dispensing device is used to perform a liquid suction operation on the target reagent container at the liquid suction position to suck the reagent carried in the target reagent container, so that there is no need for the dispensing device to move to the positions where their respective target reagent containers are located to suck the reagent during the reagent dispensing process.

[0034] After the liquid suction operation is completed, the scheduling mechanism is used again to schedule the target reagent container to the corresponding reagent storage position, thereby completing the classification management of the target reagent container. Moreover, after the target reagent container is scheduled to the liquid suction position and before it is scheduled to the corresponding reagent storage position, the first mixing device is controlled to mix at least the magnetic bead reagent container in the target reagent container. Or, during the process of scheduling the target reagent container from the reagent storage position to the liquid suction position, the first mixing device is controlled to mix at least the magnetic bead reagent container in the target reagent container, so as to effectively improve the mixing effect of the magnetic bead reagent carried in the magnetic bead reagent container, so as to maintain a good mixing state of the magnetic bead reagent before the dispensing device performs the current magnetic bead reagent suction and / or the next magnetic bead reagent suction, and finally effectively improve the accuracy and reliability of the detection results.

[0035] It should be understood that the above general description and the following detailed description are only exemplary and explanatory, and cannot limit the disclosure of the embodiments of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required for the description of the embodiments. Obviously, the following drawings are some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0037] Figure 1 It is a schematic block diagram of the structure of a sample analyzer in an embodiment;

[0038] Figure 2 It is a schematic layout diagram of the structure of a sample analyzer in an embodiment;

[0039] Figure 3 It is a schematic diagram of the structure of a sample dispensing device of a sample analyzer in an embodiment;

[0040] Figure 4 It is a schematic diagram of the structure of a reagent supply device of a sample analyzer in an embodiment;

[0041] Figure 5 It is a partial structural schematic diagram of the second mixing device of the reagent supply device of the sample analyzer in an embodiment;

[0042] Figure 6 It is a partial structural schematic diagram of the driving connection between the scheduling device and the first mixing device of the reagent supply device of the sample analyzer in an embodiment. Specific Embodiments

[0043] Next, the technical solutions in the embodiments of the present application will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are some, but not all, of the embodiments of the present application. All other embodiments obtained by those of ordinary skill in the art based on the embodiments in the present application without creative efforts shall fall within the protection scope of the present application.

[0044] In the description of the present application, unless otherwise clearly defined and limited, the terms "installation", "connection", and "connection" shall be understood in a broad sense. For example, it may be a fixed connection, a detachable connection, or an integral connection; it may be a mechanical connection or an electrical connection; it may be directly connected, or indirectly connected through an intermediate medium, and it may be the communication between two elements inside. For those of ordinary skill in the art, the specific meanings of the above terms in the present application can be understood according to specific situations.

[0045] The flowcharts shown in the accompanying drawings are only illustrative examples, and do not necessarily include all contents and operations / steps, nor do they necessarily need to be executed in the described order. For example, some operations / steps can also be decomposed, combined, or partially merged, so the actual execution order may change according to the actual situation.

[0046] Next, in conjunction with the accompanying drawings, some embodiments of the present application will be described in detail. Without conflict, the features in the following embodiments and embodiments can be combined with each other.

[0047] Please refer to Figure 1 , the present application provides a sample analyzer for analyzing a sample to be tested to obtain corresponding analysis results. In some embodiments, the sample analyzer includes but is not limited to at least one of the following: biochemical analyzer, immunoassay analyzer, coagulation analyzer, urine analyzer.

[0048] As Figure 1 shown, the sample analyzer 100 includes an analyzer execution main body (not shown in the figure) and a controller 70 communicatively connected to the analyzer execution main body. The analyzer execution main body includes a dispensing device 10, a sample supply device 20, a reagent supply device 30, a reaction device 40, a mixing device 50, and a detection device 60.

[0049] The sample supply device 20 is used to provide samples to be tested, and the reagent supply device 30 is used to provide reagents that react with the samples. Among them, the reagents include, but are not limited to, chromogenic reagents, diluents, substrate solutions, enzyme-labeled reagents, magnetic bead reagents, etc. The dispensing device 10 is used to dispense samples and / or reagents. The reaction device 40 is provided with at least one reaction position for placing reaction vessels. The reaction vessel is used to receive samples and reagents and provide a mixing place for the samples and reagents. The reaction vessel includes, but is not limited to, reaction cups. For example, the sample analyzer 100 is provided with a sample suction position and a reagent suction position. During the mixing process of the sample and the reagent, the dispensing device 10 respectively aspirates the sample supplied by the sample supply device 20 and the reagent supplied by the reagent supply device 30, and respectively dispenses the aspirated sample and reagent into the reaction vessel placed at the preset operation position, so that the sample and the reagent are mixed in the reaction vessel to form a reaction solution.

[0050] Optionally, the reaction device 40 is also used to incubate the mixture formed by mixing the sample and the reagent.

[0051] The mixing device 50 is used to perform a mixing operation. For example, after the dispensing device 10 dispenses the sample and the reagent into the reaction vessel at the corresponding reaction position of the reaction device 40, the mixing device 50 mixes the reaction solution in the reaction vessel to make the sample and the reagent fully mixed. Another example is that the mixing device 50 is used to mix the magnetic bead reagent container carrying the magnetic bead reagent to keep the magnetic bead reagent in a better mixed state.

[0052] Optionally, the mixing device 50 can be an ultrasonic mixing device that achieves mixing by sending ultrasonic waves to the target, or a stirring mixing device that achieves mixing by stirring the target with a stirring rod, or a vibration mixing device that achieves mixing by vibrating the target.

[0053] The detection device 60 is used to detect the reaction solution to obtain detection data. For example, the detection device 60 is used to measure the reaction solution in the reaction vessel to obtain the reaction data of the sample.

[0054] Optionally, the detection device 60 includes a photometric mechanism. The photometric mechanism is used to detect the luminescence intensity of the reaction solution and calculate the concentration of the component to be measured in the sample through a calibration curve, etc.

[0055] Optionally, the detection device 60 is separately arranged on the periphery of the reaction device 40.

[0056] In another embodiment, the detection device 60 includes an electrical detection mechanism (such as an impedance measurement mechanism) or a detection mechanism based on other principles (such as an imaging measurement mechanism).

[0057] Those skilled in the art should understand that Figure 1This is only an example of the sample analyzer 100 and does not constitute a limitation on the sample analyzer 100. The sample analyzer 100 may include more or fewer components than Figure 1 shown, or combine certain components, or different components. For example, the sample analyzer 100 may also include input / output devices, network access devices, etc.

[0058] Please refer to Figure 2 , in some embodiments, the reaction device 40 has a support portion 401, and at least one reaction site is provided on the support portion 401. The reaction site is used to place a reaction container (such as a reaction cup 4011). The reaction container is used to receive samples and reagents and provide a reaction site for the samples and reagents to mix and form a reaction solution. For example, the reaction container receives the samples obtained by the dispensing device 10 from the sample supply device 20 and the reagents obtained from the reagent supply device 30, so that the samples and reagents are mixed in the reaction container to form a reaction solution.

[0059] Optionally, the support portion 401 of the reaction device 40 may be a reaction disk, as Figure 2 shown, which is arranged as a disk-shaped component and has one or more reaction sites for placing reaction containers. The reaction disk can incubate the reaction solution in the reaction container and can rotate to drive the reaction container placed in the reaction site to rotate, realizing the scheduling of the reaction containers in the reaction disk in a preset area. For example, the reaction container located in the reaction site is scheduled to the position for reagent addition.

[0060] It can be understood that the reaction sites for carrying the reaction containers can be provided not only on the reaction disk of the reaction device 40 but also independently of the reaction disk of the reaction device 40. The reaction sites being provided independently of the reaction disk means that the setting of the reaction sites does not interfere with the rotation of the reaction disk itself.

[0061] Please refer to Figures 2 to 3 , in some embodiments, the sample supply device 20 may include a sample distribution module (SDM, Sample Delivery Module) and a front-end track; the sample supply device 20 may also be a sample disk, which includes a plurality of sample positions for placing sample tubes such as sample tubes. By rotating its disk-shaped component, the sample disk can schedule the samples to corresponding positions, for example, scheduling the samples to the sampling position where the dispensing device 10 sucks the samples. The dispensing device 10 is used to suck the samples and discharge them into the reaction containers to be loaded with samples.

[0062] In some embodiments, the dispensing device 10 is used to dispense samples and / or reagents. For example, the dispensing device 10 sucks the samples supplied by the sample supply device 20 and transfers the samples to the reaction containers to be loaded with samples.

[0063] Such as Figure 3As shown, optionally, the dispensing device 10 includes a sample dispensing mechanism 10a. The sample dispensing mechanism 10a is configured to aspirate the sample supplied by the sample supply device 20 and transfer the sample to a preset position. For example, the sample supply device 20 carries a sample tube containing the sample to be tested. The sample dispensing mechanism 10a aspirates the sample to be tested from the sample tube carried by the sample supply device 20 and discharges the sample into the reaction vessel to be loaded with the sample.

[0064] Among them, the sample dispensing mechanism 10a includes a sample needle 101, a first needle moving mechanism 102, and a first power mechanism 103. The first needle moving mechanism 102 is used to support the sample needle 101 and drive the sample needle 101 to move. For example, the sample needle 101 performs two-dimensional or three-dimensional movement in space through the two-dimensional or three-dimensional first needle moving mechanism 102, so that the sample needle 101 can move to aspirate the sample carried by the sample supply device 20.

[0065] The first power mechanism 103 is used to aspirate the sample through the sample needle 101. For example, the sample to be tested is a blood sample to be tested. The sample needle 101 moves to the sample tube containing the blood sample carried on the sample supply device 20 under the drive of the first needle moving mechanism 102, and aspirates the blood sample to be tested under the drive of the first power mechanism 103, and transports the blood sample to be tested into the reaction vessel at the reaction position in the reaction device 40. Thus, the blood sample to be tested aspirated by the dispensing device 10 is mixed with the reagent provided by the reagent supply device 20 in the reaction vessel.

[0066] As Figure 3 As shown, in some embodiments, the first needle moving mechanism 102 includes a support frame 1021. The support frame 1021 is fixed on the support rod 1022. The support rod 1022 can move vertically and rotate. Driven by the support rod 1022, the support frame 1021 realizes vertical movement and horizontal rotation. The sample needle 101 is arranged on the support frame 1021 and can reach the target position under the drive of the support frame 1021. Exemplarily, the first needle moving mechanism 102 further includes a driver 1023 for driving the movement of the support rod 1022. For example, the driver is a stepper motor, but of course it is not limited thereto. Optionally, the sample needle 101 is detachably connected or fixedly connected to the first needle moving mechanism 102.

[0067] Optionally, the first power mechanism 103 includes a pipeline 1031 and a power component 1033. The pipeline 1031 is used to transport the fluid medium. One end of the pipeline 1031 is communicated with the pipetting needle 101, and the other end is communicated with the power component 1033, so as to change the flow direction of the fluid medium in the pipeline 1031 under the action of the power component 1033, so that the pipetting needle 101 can perform the transfer of the sample and / or the reagent. Among them, the power component 1033 includes, but is not limited to, a syringe and a pump.

[0068] In some embodiments, the dispensing device 10 further includes a reagent dispensing mechanism 10b. The reagent supply device 30 includes a reagent carrying member 301 for carrying reagents. After the reagent dispensing mechanism 10b of the dispensing device 10 aspirates the reagents carried by the reagent supply device 30, it supplies them to the reaction device 40.

[0069] Optionally, the reagent carrying member 301 may be a reagent tray, which is arranged as a disc-shaped assembly and has a plurality of positions for carrying reagent containers. The reagent carrying member 301 can rotate and drive the reagent containers carried by it to rotate, so as to rotate the reagent containers to a specific position, such as a reagent aspiration position where the reagent is aspirated by the reagent dispensing mechanism 10b. Among them, the number of the reagent carrying members 301 can be one or more.

[0070] In some embodiments, the reagent dispensing mechanism 10b may include a reagent needle, a second needle moving mechanism, and a second power mechanism. The reagent needle performs two-dimensional or three-dimensional movement in space through the two-dimensional or three-dimensional second needle moving mechanism, so that the reagent needle can move and cooperate with the second power mechanism to aspirate the reagents carried by the reagent carrying member 301, and move to the reaction container to be added with reagents and discharge the reagents into the reaction container.

[0071] In some embodiments, the second needle moving mechanism and the first needle moving mechanism 102 have the same structure, and / or the second power mechanism and the first power mechanism 103 have the same structure, which will not be elaborated here.

[0072] In some embodiments, the reagent dispensing mechanism 10b does not add reagents in the way of a reagent needle, but adds the reagents in the reagent tube into the reaction container through a dedicated pipeline. In such embodiments, there is only the sample needle 101 and no reagent needle.

[0073] It can be understood that according to the differences in the detected body fluids and the detected items, the samples and reagents have different adding methods. For example, both the samples and reagents can be added by the sample needle 101, or the samples are added by the sample needle 101 and the reagents are added by the reagent needle, or only the samples are added by the sample needle 101 and the reagents are added by other methods. That is to say, the sample dispensing mechanism 10a of the dispensing device 10 is used for both the transfer of samples and the transfer of reagents; or the sample dispensing mechanism 10a of the dispensing device 10 is used for sample transfer, and the reagent dispensing mechanism 10b is used for reagent transfer; or the sample dispensing mechanism 10a of the dispensing device 10 is used for sample transfer, and the reagent is connected to the reagent container carrying the reagent through a dedicated pipeline to add the reagent into the reaction container. Therefore, the sample needle 101 and / or the reagent needle are also called pipetting needles, that is, the pipetting needle includes at least any one of the sample needle 101 and the reagent needle.

[0074] Please refer to Figure 2 and Figure 4 , in some embodiments, the reagent supply device 30 includes a reagent storage bin 31 and a scheduling device 32. Among them, the reagent storage bin 31 includes a number of reagent storage positions 311 for placing reagent containers. The multiple reagent storage positions 311 are arranged along a first direction, and at least two reagent storage positions 311 are stacked along a second direction different from the first direction. As Figure 4 shown, the first direction is the X-axis direction, and the second direction is the Z-axis direction. The multiple reagent storage positions 311 are arranged along the first direction and stacked along the second direction, so that more reagent containers can be placed in the three-dimensional space of the reagent storage bin 31.

[0075] The scheduling device 32 is used to perform scheduling operations, that is, the scheduling device 32 can grab or clamp an object and drive the object to move in a two-dimensional or three-dimensional space to achieve the scheduling of the object. The object includes but is not limited to reaction vessels and reagent containers. For example, before the dispensing device 10 performs reagent dispensing, the scheduling device 32 schedules the target reagent container located at the reagent storage position 311 to the corresponding liquid suction position, so that the reagent dispensing device 10 can suck the corresponding reagent at the liquid suction position and dispense it into the corresponding reaction vessel.

[0076] In some embodiments, the mixing device 50 includes a first mixing device 51 and a second mixing device 52, and the second mixing device 52 is used to mix the reagent containers placed in the multiple reagent storage positions 311.

[0077] Please refer to Figures 4 to 5 , in some embodiments, the second mixing device 52 includes a driving mechanism 521, a transmission structure 522 and a plurality of mixing mechanisms 523, and the plurality of mixing mechanisms 523 are connected to the same driving mechanism 521 through the transmission structure 522, so that the plurality of mixing mechanisms 523 can be driven by the same driving mechanism 521.

[0078] Optionally, the plurality of mixing mechanisms 523 at least include a first mixing mechanism 5231 (see Figure 6 ) and a second mixing mechanism 5232, and the first mixing mechanism 5231 and the second mixing mechanism 5232 are respectively used to mix the reagent containers placed in the reagent storage positions 311 at different heights.

[0079] The transmission structure 522 includes at least a first transmission mechanism 5221 and a second transmission mechanism 5222. Among them, the first transmission mechanism 5221 is connected to the driving mechanism 521 and the first mixing mechanism 5231; the second transmission mechanism 5222 is connected to the first transmission mechanism 5221 and the second mixing mechanism 5232, and the first transmission mechanism 5221 can deflect relative to the driving mechanism 521, and the second transmission mechanism 5222 can deflect relative to the first transmission mechanism 5221.

[0080] As Figure 5 shown, the first transmission mechanism 5221 includes a first transmission component and a second transmission component. The first transmission component is connected to the driving mechanism 521, and the second transmission component is connected to the first transmission component and can deflect relative to the first transmission component in a direction perpendicular to the output shaft of the driving mechanism 521. The first mixing mechanism 5231 and the second transmission mechanism 5222 are connected to the second transmission component.

[0081] The second transmission mechanism 5222 includes a third transmission component 5223 and a fourth transmission component 5225. The third transmission component 5223 is connected to the second transmission component of the first transmission mechanism 5221, and the fourth transmission component 5225 is connected to the third transmission component 5223 and can deflect relative to the third transmission component 5223 in a direction perpendicular to the output shaft of the driving mechanism 521. The second mixing mechanism 5222 is connected to the fourth transmission component 5225. That is, it is allowed that the extending direction of the rotation axis of the third transmission component 5223 and the extending direction of the rotation axis of the fourth transmission component 5225 form an included angle α, and the included angle α can be non-zero.

[0082] The second mixing mechanism 5222 is connected to the fourth transmission component 5225.

[0083] Exemplarily, the driving mechanism 521 is a driving motor. The driving motor is connected to the transmission structure 522 through an output shaft and drives the transmission structure 522 to rotate, so as to drive a plurality of mixing mechanisms 523 to rotate the reagent containers located at the reagent storage positions 311 by using the transmission structure 522, so as to mix the reagents carried in the reagent containers.

[0084] Based on after installing a plurality of mixing mechanisms 523 into the reagent storage bin 31, due to the corresponding tolerances introduced during the processing and installation of the mixing mechanisms 523, the connecting parts of the mixing mechanisms 523 with different heights and the transmission structure 522 are not on the same axis, which is not conducive to the assembly between the mixing mechanisms 523 and the transmission structure 522.

[0085] In this embodiment, based on the fact that the first transmission mechanism 5221 can deflect relative to the drive mechanism 521, and the second transmission mechanism 5222 can deflect relative to the first transmission mechanism 5221, the deflection of the first transmission mechanism 5221 is utilized to eliminate the tolerances generated during the processing and installation of the first mixing mechanism 5231, thereby achieving a reliable connection between the first transmission mechanism 5221 and the first mixing mechanism 5231. The deflection of the second transmission mechanism 5222 is utilized to eliminate the tolerances generated during the processing and installation of the second mixing mechanism 5232, thereby achieving a reliable connection between the second transmission mechanism 5222 and the second mixing mechanism 5232 and the first transmission mechanism 5221. Finally, the drive mechanism 521 can better drive the mixing mechanisms at different heights through the transmission structure 522 to perform a mixing operation on the reagent container located at the reagent storage position 311.

[0086] As Figure 1 shown, in some embodiments, there may be one or more controllers 70, and the controller 70 may be disposed in the analyzer execution main body or may be disposed independently of the analyzer execution main body, which is not limited herein.

[0087] Optionally, the controller 70 at least includes a processor 701, a memory 702, a communication interface (not shown in the figure), and an I / O interface (not shown in the figure). The processor 701, the memory 702, the communication interface, and the I / O interface communicate through a bus. The processor 701 may be a central processing unit (CPU), and the processor may also be other general-purpose processors, digital signal processors (DSPs), application specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Among them, the general-purpose processor may be a microprocessor or the processor may also be any conventional processor, etc.

[0088] The memory 702 stores various computer programs for the processor 701 to execute, such as operating systems and application programs, as well as data required for executing the computer programs. During the analysis of the sample to be tested, if there is data that needs to be locally stored, it can be stored in the memory 702. The I / O interface includes, but is not limited to, serial interfaces such as USB, IEEE1394, or RS-232C, parallel interfaces such as SCSI, IDE, or IEEE1284, and analog signal interfaces composed of D / A converters and converters, etc. An input component is connected to the I / O interface. The user can directly input data to the controller 70 using the input component, and the input component includes, but is not limited to, a keyboard, a mouse, a touch screen, or control buttons. The display component can be communicatively connected to the controller 70 through the I / O interface for relevant information prompting. The communication interface can be an interface of any currently known communication protocol. The communication interface communicates with the outside through a network, and the controller 70 can transmit data with any component connected through the network using a preset communication protocol.

[0089] In some embodiments, the controller 70 is at least used for, specifically, the processor 701 of the controller 70 calls the computer program in the memory 702 to perform the following operations:

[0090] Control the scheduling device 32 to schedule the target reagent container from the reagent storage position 311 to the liquid suction position;

[0091] Control the dispensing device 10 to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container. The target reagent container at least includes a magnetic bead reagent container for carrying magnetic bead reagent;

[0092] After the liquid suction operation is completed, control the scheduling device 32 to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position 311;

[0093] Among them, after the target reagent container is scheduled to the liquid suction position and before it is scheduled to the corresponding reagent storage position 311, the controller 70 is further used for: controlling the first mixing device 51 to mix the magnetic bead reagent container.

[0094] Exemplarily, during the detection of the sample by the sample analyzer 100, the target reagent required for the current detection operation is determined according to the detection item information of the sample to be tested, and then the target reagent container is determined from the reagent containers stored in the reagent storage bin 31, and the scheduling device 32 is controlled to schedule the target reagent container from the reagent storage position 311 of the reagent storage bin 31 to the corresponding liquid suction position, so that the reagent dispensing device 10 can aspirate the target reagent in the target reagent container at the liquid suction position. Among them, the target reagent container at least includes a magnetic bead reagent container for carrying magnetic bead reagent.

[0095] After the target reagent container is scheduled to the liquid suction position, the dispensing device 10 performs a liquid suction operation on the target reagent container located at the liquid suction position to suck the reagent carried in the target reagent container. After the dispensing device 10 completes the liquid suction operation on the target reagent container, the scheduling device 32 schedules the target reagent container located at the liquid suction position to the corresponding reagent storage position 311 to complete the reset of the target reagent container. Moreover, after the dispensing device 10 completes the liquid suction operation on the target reagent container, the sucked reagent is dispensed into the reaction container so that the sample and the target reagent are mixed in the reaction container to form a reaction solution, thereby facilitating the detection device 60 to detect the reaction solution and obtain the detection data corresponding to the sample.

[0096] In order to effectively improve the mixing effect of the magnetic bead reagent carried in the magnetic bead reagent container, after the target reagent container is scheduled to the liquid suction position and before the target reagent container is scheduled to the corresponding reagent storage position 311, the controller 70 is further configured to: control the first mixing device 51 to mix the magnetic bead reagent container.

[0097] Optionally, the structure for performing the liquid suction operation on the target reagent container may be the reagent dispensing mechanism 10b of the dispensing device 10 or the sample dispensing mechanism 10a. For example, after the target reagent container is scheduled to the liquid suction position, the reagent dispensing mechanism 10b performs a liquid suction operation on the target reagent container located at the liquid suction position to suck the reagent carried in the target reagent container.

[0098] In the embodiment of the present application, the reagent containers are arranged and stacked in the reagent storage bin 31 for storage, so that more reagent containers can be stored in the three-dimensional space. During the reagent dispensing process, the target reagent container in the reagent container is first scheduled to the liquid suction position, and the dispensing device is used to perform a liquid suction operation on the target reagent container at the liquid suction position to suck the reagent carried in the target reagent container, so that there is no need for the dispensing device 10 to move to the positions where their respective target reagent containers are located during the reagent dispensing process to suck the reagent.

[0099] And after the liquid suction operation is completed, the scheduling mechanism 32 is used again to schedule the target reagent container to the corresponding reagent storage position, thereby completing the homing management of the target reagent container. Moreover, after the target reagent container is scheduled to the liquid suction position and before the target reagent container is scheduled to the corresponding reagent storage position, the controller 70 controls the first mixing device 51 to mix at least the magnetic bead reagent container in the target reagent container to effectively improve the mixing effect of the magnetic bead reagent carried in the magnetic bead reagent container, so as to maintain a good mixing state of the magnetic bead reagent before the current magnetic bead reagent suction and / or the next magnetic bead reagent suction by the dispensing device, and finally effectively improve the accuracy and reliability of the detection result.

[0100] In some embodiments, the controller 70 is at least configured to, specifically, the processor 701 of the controller 70 calls a computer program in the memory 702 to perform the following operations:

[0101] Control the scheduling device 32 to schedule the target reagent container from the reagent storage position 311 to the liquid suction position;

[0102] Control the dispensing device 10 to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying a magnetic bead reagent;

[0103] After the liquid suction operation is completed, control the scheduling device 32 to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position 311;

[0104] Wherein, during the process of scheduling the target reagent container from the reagent storage position 311 to the liquid suction position, the controller 70 is further configured to: control the first mixing device 51 to mix the magnetic bead reagent container.

[0105] Different from the foregoing embodiments, the time node for the first mixing device 51 to mix the magnetic bead reagent container is different. In this embodiment, during the process of scheduling the target reagent container from the reagent storage position 311 to the liquid suction position, control the first mixing device 51 to mix at least the magnetic bead reagent container in the target reagent container, so as to effectively improve the mixing effect of the magnetic bead reagent carried in the magnetic bead reagent container, so as to maintain a good mixing state of the magnetic bead reagent before the dispensing device 10 performs the current magnetic bead reagent aspiration and / or the next magnetic bead reagent aspiration, and finally effectively improve the accuracy and reliability of the detection result.

[0106] In some embodiments, the liquid suction operation includes a first liquid suction operation and a second liquid suction operation, and the controller 70 is further configured to:

[0107] After scheduling the target reagent container to the liquid suction position, control the dispensing device 10 to perform the first liquid suction operation on the target reagent container located at the liquid suction position; after the first liquid suction operation is completed, control the first mixing device 51 to perform the first mixing operation on the target reagent container, and the first mixing operation at least mixes the magnetic bead reagent container; after the first mixing operation is completed, control the dispensing device 10 to perform the second liquid suction operation on the target reagent container located at the liquid suction position; and after the second liquid suction operation is completed, control the scheduling device 32 to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position 311.

[0108] Optionally, the first liquid suction operation and the second liquid suction operation are liquid suction operations respectively performed by the sample analyzer in two adjacent reagent dispensing cycles during continuous same-item tests.

[0109] Exemplarily, during the process of continuous identical item tests, based on two consecutive items being the same item test, thus, the types of reagents required for the target reagent are the same. Therefore, to save item test time, before the first liquid suction operation for the first item test, the target reagent container is scheduled from the reagent storage position 311 to the corresponding liquid suction position, and only after the second liquid suction operation for the second consecutive test item is completed, the scheduling device 32 is used to schedule the target reagent container to the corresponding reagent storage position 311, thereby realizing the return of the target reagent container to its original position.

[0110] Between the two consecutive first liquid suction operations and the second liquid suction operation, in order to improve the mixing effect of the magnetic bead reagent stored in at least the magnetic bead reagent container among the target reagent containers located at the liquid suction position, the controller controls the first mixing device 51 to mix at least the magnetic bead reagent container.

[0111] Optionally, after the target reagent container is scheduled from the reagent storage position 311 to the liquid suction position, the target reagent container is continuously placed at the liquid suction position, facilitating the second consecutive test item to aspirate the corresponding reagent from the target reagent container. At this time, in order to improve the mixing effect of the magnetic bead reagent stored in at least the magnetic bead reagent container among the target reagent containers located at the liquid suction position, the controller controls the first mixing device 51 to mix at least the magnetic bead reagent container located at the liquid suction position.

[0112] Optionally, the first mixing device 51 can be an ultrasonic mixing device, a stirring mixing device, or a vibrating mixing device, and the way the first mixing device 51 mixes the target reagent container can be any one of ultrasonic mixing, stirring mixing, or vibrating mixing.

[0113] For example, the first mixing device 51 includes an ultrasonic generator. After the first liquid suction operation is completed, the controller 70 controls the first mixing device 51 to perform the following during the first mixing operation on the target reagent container: controlling the ultrasonic generator to emit ultrasonic waves to the target reagent container to mix the reagent in the target reagent container; or, the first mixing device 51 includes a stirring mechanism. After the first liquid suction operation is completed, the controller 70 controls the first mixing device 51 to perform the following during the first mixing operation on the target reagent container: controlling the stirring mechanism to stir the reagent in the target reagent container to mix the reagent in the target reagent container.

[0114] In some embodiments, the scheduling device 32 is provided with a transmission mechanism 321. The first mixing device 51 is disposed on the scheduling device 32 and is in transmission connection with the scheduling device 32 through the transmission mechanism 321. After the first liquid suction operation is completed, during the process of the controller 70 controlling the first mixing device 51 to perform the first mixing operation on the target reagent container, the following operations are performed: controlling the scheduling device 32 to move the target reagent container, and during the process of the scheduling device 32 moving the target reagent container, the scheduling device 32 drives the first mixing device 51 through the transmission mechanism 321 to perform the first mixing operation on the target reagent container.

[0115] Please refer to Figure 6 , the transmission mechanism 321 can be any one of a belt transmission structure, a chain transmission structure, or a gear transmission structure. It can be understood that the transmission mechanism 321 can also be a combination of at least two of a belt transmission structure, a chain transmission structure, or a gear transmission structure.

[0116] For example, the scheduling device 32 is in transmission connection with the first mixing device 51 through a gear structure. After the target reagent container is transferred to the scheduling device 32, during the process of the controller 70 controlling the scheduling device 32 to drive the target reagent container to move, the scheduling device 32 drives the first mixing device 51 to rotate through gear transmission, and the first mixing device 51 drives the target reagent container to rotate accordingly by using the rotation, so as to realize the mixing of the corresponding target reagent in the target reagent container placed on the scheduling device 32. The target reagent container at least includes a magnetic bead reagent container for carrying magnetic bead reagents.

[0117] Optionally, the scheduling device 32 includes a first scheduling mechanism and a second scheduling mechanism, and the transmission mechanism 321 is disposed on the second scheduling mechanism. The controller 70 is further configured to:

[0118] Control the first scheduling mechanism to grab the target reagent container from the reagent storage position 311 and transfer the target reagent container to the carrying position of the second scheduling mechanism;

[0119] After the target reagent container is scheduled to the carrying position, control the second scheduling mechanism to drive the target reagent container located at the carrying position to move, and during the process of the second scheduling mechanism moving, drive the first mixing device 51 through the transmission mechanism 321 to perform the first mixing operation on the target reagent container located at the carrying position. The target reagent container at least includes a magnetic bead reagent container.

[0120] In some embodiments, the scheduling device 32 is provided with a carrying position. During the process of the controller 70 controlling the first mixing device 51 to mix the magnetic bead reagent container, the following operations are performed: controlling the scheduling device 32 to move the target reagent container carried at the carrying position, and during the process of the scheduling device 32 moving the target reagent container, the first mixing device 51 mixes the target reagent container carried at the carrying position.

[0121] Exemplarily, after the target reagent container is transferred to the carrying position of the scheduling device 32, the scheduling device 32 moves the target reagent container from the reagent storage position 311 to the liquid suction position, and during the movement of the scheduling device 32, the first mixing device 51 mixes the target reagent container carried on the carrying position.

[0122] And / or, after the target reagent container is transferred to the carrying position of the scheduling device 32, the scheduling device 32 moves the target reagent container from the liquid suction position to the reagent storage position 311, and during the movement of the scheduling device 32, the first mixing device 51 mixes the target reagent container carried on the carrying position.

[0123] It can be understood that the manner in which the first mixing device 51 mixes the target reagent container carried on the carrying position includes but is not limited to any one of vibration mixing, stirring mixing, and ultrasonic mixing.

[0124] Another way for the first mixing device 51 to mix the target reagent container carried on the carrying position is that the scheduling device 32 is provided with a transmission mechanism 321. During the process of the scheduling device 32 moving the target reagent container, the scheduling device 32 drives the first mixing device 51 to perform a mixing operation on the target reagent container through the transmission mechanism 321.

[0125] The mixing control method provided by the embodiments of the present application will be described below in combination with the working principle of the sample analyzer 100.

[0126] The embodiments of the present application further provide a mixing control method, which is applied to the aforementioned sample analyzer 100, and the method includes:

[0127] Controlling the scheduling device of the sample analyzer to schedule the target reagent container from the reagent storage position to the liquid suction position;

[0128] Controlling the dispensing device of the sample analyzer to perform a liquid suction operation on the target reagent container located at the liquid suction position to suck the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying a magnetic bead reagent;

[0129] After the liquid suction operation is completed, controlling the scheduling device of the sample analyzer to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position;

[0130] Wherein, after the target reagent container is scheduled to the liquid suction position and before the target reagent container is scheduled to the corresponding reagent storage position, the method further includes: controlling the sample analyzer to mix the magnetic bead reagent container.

[0131] Alternatively, the method further includes: during the process of scheduling the target reagent container from the reagent storage position 311 to the liquid suction position, controlling the first mixing device to mix the magnetic bead reagent container.

[0132] In some embodiments, the liquid suction operation includes a first liquid suction operation and a second liquid suction operation, and the method further includes:

[0133] After scheduling the target reagent container to the liquid suction position, controlling the dispensing device to perform the first liquid suction operation on the target reagent container located at the liquid suction position;

[0134] After the first liquid suction operation is completed, controlling the first mixing device to perform a first mixing operation on the target reagent container, and the first mixing operation at least mixes the magnetic bead reagent container;

[0135] After the first mixing operation is completed, controlling the dispensing device to perform the second liquid suction operation on the target reagent container located at the liquid suction position; and

[0136] After the second liquid suction operation is completed, controlling the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position.

[0137] In some embodiments, the first liquid suction operation and the second liquid suction operation are liquid suction operations respectively performed by the sample analyzer in two adjacent reagent dispensing cycles during continuous testing of the same item.

[0138] In some embodiments, after the first liquid suction operation is completed, controlling the first mixing device to perform the first mixing operation on the target reagent container includes:

[0139] Controlling the first mixing device to perform the first mixing operation on the target reagent container located at the liquid suction position.

[0140] In some embodiments, the first mixing device includes an ultrasonic generator. After the first liquid suction operation is completed, controlling the first mixing device to perform the first mixing operation on the target reagent container includes:

[0141] Controlling the ultrasonic generator to emit ultrasonic waves to the target reagent container to mix the reagent in the target reagent container;

[0142] Alternatively, the first mixing device includes a stirring mechanism. After the first liquid suction operation is completed, controlling the first mixing device to perform the first mixing operation on the target reagent container includes:

[0143] Control the stirring mechanism to stir the reagent in the target reagent container to mix the reagent in the target reagent container evenly.

[0144] In some embodiments, the scheduling device is provided with a transmission mechanism. The first mixing device is arranged on the scheduling device and is in transmission connection with the scheduling device through the transmission mechanism. After the first liquid suction operation is completed, controlling the first mixing device to perform a first mixing operation on the target reagent container includes:

[0145] Control the scheduling device to move the target reagent container, and during the process of the scheduling device moving the target reagent container, the scheduling device drives the first mixing device to perform the first mixing operation on the target reagent container through the transmission mechanism.

[0146] In some embodiments, the scheduling device includes a first scheduling mechanism and a second scheduling mechanism, and the transmission mechanism is arranged on the second scheduling mechanism. The method further includes:

[0147] Control the first scheduling mechanism to grab the target reagent container from the reagent storage position and transfer the target reagent container to the carrying position of the second scheduling mechanism;

[0148] After the target reagent container is scheduled to the carrying position, control the second scheduling mechanism to drive the target reagent container located at the carrying position to move, and during the process of the second scheduling mechanism moving, drive the first mixing device to perform the first mixing operation on the target reagent container located at the carrying position through the transmission mechanism.

[0149] In some embodiments, the scheduling device is provided with a carrying position. Controlling the first mixing device to mix the magnetic bead reagent container includes:

[0150] Control the scheduling device to move the target reagent container carried on the carrying position, and during the process of the scheduling device moving the target reagent container, the first mixing device mixes the target reagent container carried on the carrying position.

[0151] It should be noted that those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working process of the above-described mixing control method can refer to the corresponding working process of the foregoing sample analyzer, and will not be elaborated herein.

[0152] It should be understood that the terms used in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application. As used in the specification of this application and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an" and "the" are intended to include the plural forms.

[0153] It should also be understood that the term "and / or" used in the specification of this application and the appended claims refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations. It should be noted that in this document, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or system comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article or system. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or system comprising the element.

[0154] The serial numbers of the embodiments of this application above are only for description and do not represent the superiority or inferiority of the embodiments. The above are only specific embodiments of this application, but the protection scope of this application is not limited thereto. Any person skilled in the art within the technical scope disclosed in this application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of this application. Therefore, the protection scope of this application shall be subject to the protection scope of the claims.

Claims

1. A sample analyzer, characterized in that, The sample analyzer includes: A reagent storage bin, including a number of reagent storage positions for placing reagent containers, multiple said reagent storage positions are arranged along a first direction, and at least two said reagent storage positions are stacked along a second direction different from the first direction; A dispensing device for dispensing samples and / or reagents; A reaction device, provided with at least one reaction position for placing a reaction container, the reaction container is used to receive the samples and reagents dispensed by the dispensing device, so that the samples and the reagents are mixed to form a reaction solution, and the reagent at least includes a magnetic bead reagent; A first mixing device for performing a mixing operation; A scheduling device for performing a scheduling operation; and A controller, at least communicatively connected to the dispensing device and the scheduling device, and configured to: Control the scheduling device to schedule a target reagent container from the reagent storage position to the liquid suction position; Control the dispensing device to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, and the target reagent container at least includes a magnetic bead reagent container for carrying the magnetic bead reagent; After the liquid suction operation is completed, control the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position; Wherein, the controller is further configured to: after scheduling the target reagent container to the liquid suction position and before scheduling the target reagent container to the corresponding reagent storage position, control the first mixing device to mix the magnetic bead reagent container.

2. The sample analyzer according to claim 1, wherein, The liquid suction operation includes a first liquid suction operation and a second liquid suction operation, and the controller is further configured to: After scheduling the target reagent container to the liquid suction position, control the dispensing device to perform the first liquid suction operation on the target reagent container located at the liquid suction position; After the first liquid suction operation is completed, control the first mixing device to perform a first mixing operation on the target reagent container, and the first mixing operation at least mixes the magnetic bead reagent container; After the first mixing operation is completed, control the dispensing device to perform the second liquid suction operation on the target reagent container located at the liquid suction position; and After the second liquid suction operation is completed, control the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position.

3. The sample analyzer according to claim 2, characterized in that, The first liquid suction operation and the second liquid suction operation are liquid suction operations respectively performed by the sample analyzer in two adjacent reagent dispensing cycles during continuous testing of the same item.

4. The sample analyzer according to claim 2, characterized in that, After the first liquid suction operation is completed, during the process that the controller controls the first mixing device to perform a first mixing operation on the target reagent container, the controller performs: Control the first mixing device to perform the first mixing operation on the target reagent container located at the liquid suction position.

5. The sample analyzer according to claim 2, characterized in that, The first mixing device includes an ultrasonic generator. After the first liquid suction operation is completed, during the process that the controller controls the first mixing device to perform a first mixing operation on the target reagent container, the controller performs Control the ultrasonic generator to emit ultrasonic waves to the target reagent container to mix the reagent in the target reagent container; Alternatively, the first mixing device includes a stirring mechanism. After the first liquid suction operation is completed, when the controller controls the first mixing device to perform the first mixing operation on the target reagent container, the following operations are performed: Control the stirring mechanism to stir the reagent in the target reagent container to mix the reagent in the target reagent container.

6. The sample analyzer according to claim 2, characterized in that, The scheduling device is provided with a transmission mechanism. The first mixing device is arranged on the scheduling device and is in transmission connection with the scheduling device through the transmission mechanism. After the first liquid suction operation is completed, when the controller controls the first mixing device to perform the first mixing operation on the target reagent container, the following operations are performed: Control the scheduling device to move the target reagent container, and during the process of the scheduling device moving the target reagent container, the scheduling device drives the first mixing device to perform the first mixing operation on the target reagent container through the transmission mechanism.

7. The sample analyzer according to claim 6, characterized in that, The scheduling device includes a first scheduling mechanism and a second scheduling mechanism, and the transmission mechanism is arranged on the second scheduling mechanism. The controller is further configured to: Control the first scheduling mechanism to grab the target reagent container from the reagent storage position and transfer the target reagent container to the carrying position of the second scheduling mechanism; After the target reagent container is scheduled to the carrying position, control the second scheduling mechanism to drive the target reagent container located at the carrying position to move, and during the movement of the second scheduling mechanism, drive the first mixing device to perform the first mixing operation on the target reagent container located at the carrying position through the transmission mechanism.

8. The sample analyzer according to claim 1, wherein, The scheduling device is provided with a carrying position. When the controller controls the first mixing device to mix the magnetic bead reagent container, the following operations are performed: Control the scheduling device to move the target reagent container carried on the carrying position, and during the process of the scheduling device moving the target reagent container, the first mixing device mixes the target reagent container carried on the carrying position.

9. The sample analyzer according to any one of claims 1-8, characterized in that, The sample analyzer further includes a second mixing device for mixing the reagent containers placed in a plurality of the reagent storage positions.

10. The sample analyzer according to claim 9, characterized in that, The second mixing device includes a driving mechanism, a transmission structure, and a plurality of mixing mechanisms, and the plurality of mixing mechanisms are connected to the same driving mechanism through the transmission structure.

11. The sample analyzer according to claim 10, characterized in that, The plurality of mixing mechanisms at least include a first mixing mechanism and a second mixing mechanism, and the first mixing mechanism and the second mixing mechanism are respectively used for mixing the reagent containers placed in the reagent storage positions at different heights; The transmission structure at least includes a first transmission mechanism and a second transmission mechanism. Among them, the first transmission mechanism is connected to the driving mechanism and the first mixing mechanism; the second transmission mechanism is connected to the first transmission mechanism and the second mixing mechanism, and the second transmission mechanism can deflect relative to the first transmission mechanism.

12. A sample analyzer, characterized in that, The sample analyzer includes: A reagent storage bin, comprising a number of reagent storage positions for placing reagent containers, multiple said reagent storage positions being arranged along a first direction, and at least two said reagent storage positions being stacked along a second direction different from the first direction; A dispensing device for dispensing samples and / or reagents; A reaction device provided with at least one reaction position for placing a reaction container, the reaction container being used to receive the samples and reagents dispensed by the dispensing device so that the samples and the reagents are mixed to form a reaction solution, and the reagent at least includes a magnetic bead reagent; A scheduling device for performing scheduling operations; A first mixing device for performing mixing operations, and A controller communicatively connected to at least the dispensing device, the scheduling device, and the first mixing device, and configured to: Control the scheduling device to schedule a target reagent container from the reagent storage position to the liquid suction position; Control the dispensing device to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, the target reagent container at least including a magnetic bead reagent container for carrying the magnetic bead reagent; After the liquid suction operation is completed, control the scheduling device to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position; Wherein, the controller is further configured to: during the process of scheduling the target reagent container from the reagent storage position to the liquid suction position, control the first mixing device to mix the magnetic bead reagent container.

13. A mixing control method, applied to a sample analyzer, characterized in that, The method includes: Controlling the scheduling device of the sample analyzer to schedule a target reagent container from the reagent storage position to the liquid suction position; Controlling the dispensing device of the sample analyzer to perform a liquid suction operation on the target reagent container located at the liquid suction position to aspirate the reagent carried in the target reagent container, the target reagent container at least including a magnetic bead reagent container for carrying the magnetic bead reagent; After the liquid suction operation is completed, controlling the scheduling device of the sample analyzer to schedule the target reagent container located at the liquid suction position to the corresponding reagent storage position; Wherein, after scheduling the target reagent container to the liquid suction position and before scheduling the target reagent container to the corresponding reagent storage position, the method further includes: controlling the sample analyzer to mix the magnetic bead reagent container.

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