High-adhesion sterile hydrogel patch and preparation method thereof

Abstract

The invention belongs to the technical field of sterile hydrogel patches, and particularly relates to a high-adhesion sterile hydrogel patch and a preparation method thereof. According to the preparation method of the high-adhesion sterile hydrogel patch, the high-adhesion sterile hydrogel patch is of a three-layer structure, the middle is a gel layer, the upper layer is a PE type release film, and the lower layer is a PE plastic sheet. According to the high-adhesion sterile hydrogel patch and the preparation method thereof, the formula of the high-adhesion sterile hydrogel patch is adjusted, a double-crosslinking system is utilized, the strength and toughness of hydrogel are guaranteed, meanwhile, the high-adhesion sterile hydrogel patch has high viscosity, low water loss rate and low swelling performance, the product can be repeatedly washed and worn, and in addition, the application range of the high-adhesion sterile hydrogel patch is widened. The cold compress analgesic effect is good; the invention further provides a preparation method, the preparation process is simple, and the whole process is non-toxic and harmless.

Description

Technical Field

[0001] The present invention belongs to the technical field of sterile hydrogel patches, and particularly relates to a highly adhesive sterile hydrogel patch and a preparation method thereof. Background Art

[0002] Hydrogel is a substance formed by hydrophilic polymers absorbing water and swelling, which shows broad application prospects in the medical and household fields. Currently, in the medical and household environments, the commonly used solid hydrogel materials are acrylics, polyacrylamides, polyvinyl alcohols, cold gels, and polyurethanes. However, except for some acrylic hydrogels with adhesion ability, other types of hydrogels cannot maintain high adhesion at the original water content.

[0003] To achieve high adhesion of hydrogel products, a film with a pressure-sensitive adhesive is usually used for fixation. However, a large gel area will affect the fixation of the pressure-sensitive adhesive, greatly limiting the use scenarios of solid hydrogels, that is, it cannot be applied to large-area wounds or some fields that require repeated wearing, such as the use of breast pads; moreover, the too-strong adhesion of the pressure-sensitive adhesive will cause a certain degree of discomfort, making it impossible to be used on relatively sensitive parts of the human body, unable to use a large area of gel, and not easy to be repeatedly worn.

[0004] CN117064626A discloses a medical hydrogel patch, which is processed from materials such as polyvinyl alcohol, polyacrylic acid, methyl ester, tartaric acid, purified water, triethanolamine, glycerol, propylene glycol, sodium polyacrylate, polyacrylic acid, glycohydroxyaluminum, disodium edetate (ethylenediaminetetraacetic acid disodium), and propyl ester. The product has a uniform thickness of the colloid, neat cutting, no glue peeling, glue overflowing, or glue seeping, saves the curing time of the gel body, has a high water content and good viscosity. However, this hydrogel patch has too high water absorption, is prone to absorb a large amount of water during the rinsing process with clean water, resulting in deformation and loss of viscosity, and cannot be washed with water and reused.

[0005] CN115350165A discloses a gel for a medical antipyretic patch and a preparation method thereof. Using glycerol, sodium polyacrylate, polyvinylpyrrolidone, etc. as raw materials, after weighing, preparing an aqueous phase and an oil phase, mixing to form a gel, and then coating it on a non-woven fabric and covering it with a polyethylene film and cutting to make a medical antipyretic patch; the gel has a long-lasting and mild cooling effect. Polyvinylpyrrolidone is an ideal water-based adhesive, which can keep the medical antipyretic patch firmly adhered to the skin for a long time, preventing it from falling off the head. At the same time, it is water-soluble and not easy to remain; this hydrogel patch is relatively soft and cannot be used without the non-woven fabric. The non-woven fabric is opaque, and there are deficiencies in heat dissipation and water evaporation. Moreover, this hydrogel also has the problem of too high water absorption, resulting in inability to be washed with water. Summary of the Invention

[0006] The object of the present invention is to overcome the defects existing in the prior art and provide a highly adhesive sterile hydrogel patch. By using a double cross-linking system, while ensuring the strength and toughness of the hydrogel, it has high viscosity, low water loss rate and low swelling performance, and the product can be washed and worn repeatedly. In addition, it also has a good cold compress analgesic effect. The present invention also provides a preparation method thereof, the preparation process is simple, and it is non-toxic and harmless throughout the process.

[0007] The preparation method of the highly adhesive sterile hydrogel patch described in the present invention, the highly adhesive sterile hydrogel patch has a three-layer structure, the middle is a gel layer, the upper layer is a PE type release film, and the lower layer is a PE plastic sheet. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat up to 85 - 95 °C, and stir to obtain a mixed aqueous solution, denoted as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, antioxidant, and cross-linking regulator to glycerol and 1,4-butanediol, and stir until a homogeneous phase solution is formed, denoted as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on the PE plastic sheet to obtain a gel layer, and attach a PE type release film to the gel layer through a coater; S5: Cut and bag; S6: Perform 60 γ-ray irradiation molding with Co to obtain a highly adhesive sterile hydrogel patch; Among them, by mass, the addition amount of polyvinyl alcohol is 5 - 7 parts, the addition amount of water is 40 - 59 parts, the total addition amount of glycerol is 25 - 35 parts, the addition amount of sodium polyacrylate is 1 - 2 parts, the addition amount of polyvinylpyrrolidone is 4 - 7 parts, the addition amount of antioxidant is 0.0075 - 0.015 parts, and the addition amount of 1,4-butanediol is 5 - 7 parts; the mass ratio of the sodium polyacrylate, cross-linking regulator, and tartaric acid is 1.5: (0.13 - 0.2): (0.04 - 0.06).

[0008] The mass ratio of the polyvinyl alcohol and polyvinylpyrrolidone is 1: (0.8 - 1).

[0009] The antioxidant is composed of butylated hydroxyanisole and citric acid, and the mass ratio of butylated hydroxyanisole and citric acid is (1.8 - 2.2): 1. Preferably, the mass ratio of butylated hydroxyanisole and citric acid is 2: 1.

[0010] The cross-linking regulator is composed of aluminum glycinate and disodium edetate, and the mass ratio of aluminum glycinate and disodium edetate is (3 - 3.5): 1.

[0011] In the step S2, by mass, the addition amount of glycerol is 10 - 20 parts.

[0012] The mass ratio of the total amount of glycerol added to the amount of 1,4-butanediol added is 5:(0.8 - 1.2). Preferably, the mass ratio of the total amount of glycerol added to the amount of 1,4-butanediol added is 5:1.

[0013] In the step S4, the thickness of the gel layer is 1.9 - 2.1 mm, the thickness of the PE plastic sheet is 200 - 250 μm, and the thickness of the PE release film is 50 - 60 μm.

[0014] In the step S6, 60 The γ-ray irradiation dose of Co is 15 - 30 kGy.

[0015] The high-adhesion sterile hydrogel patch described above is prepared by the preparation method of the high-adhesion sterile hydrogel patch.

[0016] Preferably, the high-adhesion sterile hydrogel patch prepared by the present invention is applied to larger-area wounds or some fields where repeated wearing is required.

[0017] The high-adhesion sterile hydrogel patch of the present invention adopts a double-crosslinking system. Among them, sodium polyacrylate and aluminum glycollate are used as a chemical crosslinking system. The complexation equilibrium of aluminum ions is achieved in the system through the crosslinking regulator aluminum glycollate. A chemical crosslinking reaction occurs between the free aluminum ions and sodium polyacrylate to form a gel. The chemical crosslinking system starts to react immediately when the components are stirred and mixed. The initial reaction time is 3 - 4 h, and the complete reaction time is 1 - 2 days. Coating can be carried out in the time period before the initial reaction, which is convenient for processing.

[0018] Polyvinyl alcohol and polyvinylpyrrolidone are an irradiation crosslinking system. In this system, a large number of free radicals are generated after polyvinyl alcohol is irradiated by high-energy rays, so that the chain segments can directly carry out crosslinking reactions to form a hydrogel. Polyvinyl alcohol and polyvinylpyrrolidone have a physical thickening effect on sodium polyacrylate in the chemical reaction stage. The formed gel layer is relatively stable. After the product is cut, bagged and irradiated and sterilized, polyvinyl alcohol and polyvinylpyrrolidone undergo irradiation crosslinking, and finally a high-adhesion sterile hydrogel patch with a double-network interpenetrating structure is formed. The crosslinking of polyvinyl alcohol and polyvinylpyrrolidone provides the basic strength and toughness for the hydrogel, and then through the double-crosslinking network system, it combines with the sodium polyacrylate hydrogel in the system to form a non-shedding adhesive layer on the surface.

[0019] On the basis of ensuring that the crosslinking environments of the two crosslinking systems do not conflict and have similar crosslinking strengths, by adjusting the proportion of the two systems, they can be compatible and produce a synergistic effect, enabling the product to have strength and toughness while also having high viscosity, low water loss rate, and low swelling properties. At the same time, the double crosslinking system uses stepwise crosslinking, first chemical crosslinking and then irradiation crosslinking, so that the two crosslinking systems can be evenly dispersed and combined. The two crosslinking systems achieve a synergistic effect through physical entanglement, without relying on chemical reactions, effectively avoiding performance fluctuations caused by chemical side reactions, and ensuring the stability and repeatability of the product performance.

[0020] Compared with the prior art, the present invention has the following beneficial effects: (1) The highly adhesive sterile hydrogel patch of the present invention, compared with the traditional hydrogel patch with a single material and a single crosslinking method, the chemically crosslinked sodium polyacrylate component gives the overall adhesion ability of the hydrogel. In the system, the components other than water and glycerol account for more than 15 wt.% of the overall components, which is greater than 8 wt.% of the general antipyretic hydrogel. Combined with the hygroscopic ability of glycerol, the water retention performance of the hydrogel is more excellent. Moreover, the double crosslinking network increases the cohesion of the hydrogel, while ensuring the strength and toughness of the hydrogel, enabling it to have a low water loss rate and low swelling properties, making the product have a moderate hardness and better solid shape.

[0021] (2) The highly adhesive sterile hydrogel patch of the present invention adjusts the crosslinking ratio, uses irradiation crosslinking as the main crosslinking method, uses a relatively small amount of sodium polyacrylate for chemical crosslinking, and at the same time introduces an antioxidant, eliminating the problem of yellowing and odor generation due to the irradiation oxidation of sodium polyacrylate, so that the hydrogel can adopt the irradiation sterilization method, and thus can be applied in some medical fields with strict aseptic environment requirements.

[0022] (3) The preparation method of the highly adhesive sterile hydrogel patch of the present invention has a simple preparation process and is non-toxic and harmless throughout the process. Specific embodiments

[0023] The following further illustrates the present invention in combination with examples and comparative examples. The raw materials used in the examples and comparative examples are all conventional commercially available raw materials unless otherwise specified, and the process methods used are all conventional methods in the art unless otherwise specified. The parts involved in the raw materials in the examples and comparative examples are all parts by mass.

[0024] The preparation method of the highly adhesive sterile hydrogel patch, the highly adhesive sterile hydrogel patch has a three-layer structure, the middle is a gel layer, the upper layer is a PE type release film, and the lower layer is a PE plastic sheet. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat up to 85 - 95 °C, and stir at a speed of 500 r / min for 30 min. After obtaining the mixed aqueous solution, cool it to room temperature and denote it as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, butylated hydroxyanisole, citric acid, glyceryl aluminum hydroxide, and disodium edetate to the remaining glycerol and 1,4 - butanediol, and stir at a speed of 1500 r / min until a homogeneous solution is formed, and denote it as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on a PE plastic sheet to obtain a gel layer, and attach a PE - type release film to the gel layer through a coater; S5: Perform cutting and bagging; S6: Perform 60 γ - ray irradiation forming with Co, the irradiation dose is 15 - 30 kGy, and the irradiation rate is 2 MeV to obtain a highly adhesive sterile hydrogel patch.

[0025] Example 1 For the preparation method of the highly adhesive sterile hydrogel patch described above, the highly adhesive sterile hydrogel patch has a three - layer structure, with a gel layer in the middle, a PE - type release film on the upper layer, and a PE plastic sheet on the lower layer. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat up to 90 °C, and stir at a speed of 500 r / min for 30 min. After obtaining the mixed aqueous solution, cool it to room temperature and denote it as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, butylated hydroxyanisole, citric acid, glyceryl aluminum hydroxide, and disodium edetate to the remaining glycerol and 1,4 - butanediol, and stir at a speed of 1500 r / min until a homogeneous solution is formed, and denote it as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on a 200 - μm PE plastic sheet to obtain a gel layer, the thickness of the gel layer is 2.0 mm, and attach a PE - type release film to the gel layer through a coater. The thickness of the PE - type release film is 50 μm; S5: Perform cutting and bagging; S6: Perform 60 γ - ray irradiation forming with Co, the irradiation dose is 25 kGy, and the irradiation rate is 2 MeV to obtain a highly adhesive sterile hydrogel patch.

[0026] In the highly adhesive sterile hydrogel patch of this example, the addition amounts of each raw material are shown in Table 1.

[0027] Table 1 The addition amounts of each raw material in Example 1

[0028] Example 2 The preparation method of the highly adhesive sterile hydrogel patch. The highly adhesive sterile hydrogel patch has a three-layer structure, with a gel layer in the middle, a PE type release film on the upper layer, and a PE plastic sheet on the lower layer. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat up to 85°C, and stir at a speed of 500 r / min for 30 min. After obtaining the mixed aqueous solution, cool it to room temperature and record it as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, butylated hydroxyanisole, citric acid, glycine aluminum, and disodium edetate to the remaining glycerol and 1,4-butanediol, and stir at a speed of 1500 r / min until a homogeneous phase is formed, and record it as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on a 220-μm PE plastic sheet to obtain a gel layer with a thickness of 2.1 mm. Attach a PE type release film with a thickness of 55 μm to the gel layer through a coater; S5: Cut and bag; S6: Perform 60 γ-ray irradiation forming with Co, with an irradiation dose of 30 kGy and an irradiation rate of 2 MeV, to obtain the highly adhesive sterile hydrogel patch.

[0029] In the highly adhesive sterile hydrogel patch of this example, the addition amounts of each raw material are shown in Table 2.

[0030] Table 2 The addition amounts of each raw material in Example 2

[0031] Example 3 The preparation method of the highly adhesive sterile hydrogel patch. The highly adhesive sterile hydrogel patch has a three-layer structure, with a gel layer in the middle, a PE type release film on the upper layer, and a PE plastic sheet on the lower layer. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat up to 95°C, and stir at a speed of 500 r / min for 30 min. After obtaining the mixed aqueous solution, cool it to room temperature and record it as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, butylated hydroxyanisole, citric acid, glycine aluminum, and disodium edetate to the remaining glycerol and 1,4-butanediol, and stir at a speed of 1500 r / min until a homogeneous phase is formed, and record it as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on a 250-μm PE plastic sheet to obtain a gel layer with a thickness of 1.9 mm. Attach a PE type release film with a thickness of 60 μm to the gel layer through a coater; S5: Perform cutting and bagging; S6: Perform 60 γ-ray irradiation forming of Co with an irradiation dose of 15 kGy and an irradiation rate of 2 MeV to obtain a highly adhesive sterile hydrogel patch.

[0032] In the highly adhesive sterile hydrogel patch of this example, the addition amounts of each raw material are shown in Table 3.

[0033] Table 3 Addition amounts of each raw material in Example 3

[0034] Comparative Example 1 This comparative example is the same as Example 1, except that glycerol in the first component is removed and replaced with water in the same mass fraction, and the mass fraction of glycerol in the second component is still 15. The other components and specific steps are the same as those in Example 1.

[0035] Comparative Example 2 This comparative example is the same as Example 1, except that the crosslinking regulator is not added, and the change in the total addition amount of raw materials due to the lack of the crosslinking regulator is made up with water. The other components and specific steps are the same as those in Example 1.

[0036] Comparative Example 3 The difference from Example 1 is that the addition amounts of each raw material are shown in Table 4.

[0037] Table 4 Addition amounts of each raw material in Comparative Example 3

[0038] Comparative Example 4 The difference from Example 1 is that the addition amounts of each raw material are shown in Table 5.

[0039] Table 5 Addition amounts of each raw material in Comparative Example 4

[0040] Comparative Example 5 This comparative example is the same as Example 1, except that the antioxidants (butylated hydroxyanisole and citric acid) in the second component are removed, and the change in the total addition amount of raw materials due to the lack of the antioxidants is made up with water. The other components and specific steps are the same as those in Example 1.

[0041] Comparative Example 6 This comparative example is the same as Example 1, except that the mass ratio of the total addition amounts of 1,4-butanediol and glycerol is 1:2, the total addition amount of glycerol is 30 parts, the total addition amount of raw materials is kept the same as that in Example 1, and the corresponding amount of water is reduced, and the other components and specific steps are the same as those in Example 1.

[0042] Comparative Example 7 This comparative example is the same as Example 1, except that the addition amounts of polyvinyl alcohol and polyvinylpyrrolidone are both 3 parts, the total addition amount of raw materials is kept the same as that in Example 1, and the corresponding amount of water is supplemented, and the other components and specific steps are the same as those in Example 1.

[0043] Comparative Example 8 The difference from Example 1 is that the addition amounts of each raw material are shown in Table 6.

[0044] Table 6 Addition amounts of each raw material in Comparative Example 8

[0045] The high-adhesion sterile hydrogel patches prepared in the above examples and comparative examples were tested according to the following self-defined standards based on the problems encountered in the actual use process: Experiment 1: Use a product with a specification of 7.5×7.5 cm and 2 mm thickness as the experimental object. Remove the plastic sheet and PE-type release film from the unpacked product, weigh it, place it in an oven at 37±0.5 °C for 24 h, weigh it again, and calculate the water loss amount by the weighing method, aiming to simulate the water loss situation of the high-adhesion sterile hydrogel patch when worn on the human body surface for one day.

[0046] Experiment 2: Use a product with a specification of 7.5×7.5 cm and 2 mm thickness as the experimental object. Remove the plastic sheet and PE-type release film from the unpacked product, weigh it, soak it in purified water at about 23 °C for 30 min, use tweezers to pick out the hydrogel and let it stand for 30 s to ensure that there is no flowing liquid on the surface, then weigh it, and calculate the water absorption amount by the weighing method, aiming to simulate the water absorption amount of the hydrogel after being rinsed or soaked in water, reflect the water absorption rate and the change after swelling of the hydrogel, and check whether it has the performance of being washable and reusable. The less the swelling water absorption amount and the smaller the change of the gel, the more stable it is.

[0047] Experiment 3: Use a product with a specification of 7.5×7.5 cm and 2 mm thickness as the experimental object, and test the adhesiveness of the product with reference to the adhesiveness test method in YY / T0148-2006 to test the adhesion ability of the product surface.

[0048] Experiment 4: Use the product with the specification of 7.5×7.5 cm and 2 mm thickness as the experimental object. Remove the plastic sheet and PE type release film from the unpacked product, weigh it, soak it in purified water at about 23°C for 3 minutes, then take it out and let it stand in the air environment for 2 minutes, and test the stickiness of the product according to the adhesion test method in YY / T0148-2006 to test the adhesion ability of the product after washing.

[0049] According to the above experimental method, the product performance test results are shown in Table 7 - Table 10.

[0050] Table 7 Water retention performance test results under the conditions of Experiment 1

[0051] Table 8 Water absorption performance test results under the conditions of Experiment 2

[0052] Table 9 Product adhesion ability test results under the conditions of Experiment 3

[0053] Table 10 Product adhesion ability test results under the conditions of Experiment 4

[0054] It can be seen from Table 7 - Table 10 that when comparing Comparative Example 1 and Example 1, due to the low glycerol addition amount in Comparative Example 1, the water retention performance of the product is poor, more water is lost during use, and the product stability and adhesion performance decline.

[0055] When comparing Comparative Example 2 and Example 1, since no crosslinking regulator is added in Comparative Example 2, therefore, the sodium polyacrylate in the components does not undergo chemical crosslinking, and the product only has a single crosslinking system, with a low crosslinking degree of the product and a relatively loose crosslinking network. As a result, the water retention performance declines, and the uncrosslinked sodium polyacrylate partially dissolves in water, is prone to swelling and collapse, and the morphology changes greatly after water absorption, resulting in a decrease in product stability; secondly, the single crosslinking system leads to limited stickiness of the product, and the surface hydrogel is easy to fall off, and the product cannot be reused after washing.

[0056] The comparison between Comparative Example 3, Comparative Example 4 and Example 1 shows that when the addition amount of sodium polyacrylate in the raw materials is too low, it affects the crosslinking degree of the product, the chemical crosslinking components are insufficient, the network density is low, and water molecules are easy to diffuse freely, resulting in a decline in the water retention performance of the product, an increase in water absorption, and a decrease in adhesion performance; while when the addition amount of sodium polyacrylate in the raw materials is too high, the content of components participating in chemical crosslinking is too much, and the chemical crosslinking ratio is higher than the radiation crosslinking. Although the increase in crosslinking degree is beneficial to the improvement of the mechanical properties of the product, it affects the radiation crosslinking, the water retention performance of the product declines, the water absorption increases due to the high water absorption of the chemical crosslinking components, and the prepared hydrogel has a soft texture and insufficient stickiness.

[0057] Comparison between Comparative Example 5 and Example 1 shows that when no antioxidant is added, the sodium polyacrylate in the chemical cross-linking component oxidizes and turns yellow. Although from the performance point of view, it has little effect on the water retention, water absorption and peel strength of the product, it has a greater impact on the actual use effect of the product.

[0058] Comparison between Comparative Example 6 and Example 1 shows that 1,4-butanediol can promote the dispersion of sodium polyacrylate, but excessive amount will dilute the concentration of the crosslinker, making stirring and defoaming difficult during processing, thereby improving the water retention of the product, while excessive water absorption and decreased water content will lead to a slight decrease in peel strength.

[0059] Comparison between Comparative Example 7 and Example 1 shows that the content of the radiation cross-linked component is reduced, the degree of cross-linking is insufficient, the physical cross-linking points are reduced, and the network strength is reduced, resulting in the hydrogel being soft and easy to break, further affecting the stability of the product; and its cross-linking density is low, so that water molecules are easily lost through the pores, and the water retention is poor.

[0060] Comparison between Comparative Example 8 and Example 1 shows that the water loss and water absorption of the product prepared by single chemical crosslinking are much higher than those of the double crosslinking system. The hydrogel with sodium polyacrylate as the main component has good adhesion ability without water washing, but after water washing and soaking, due to excessive water absorption, the water dispersion is lost in a short time. Excessive water content will cause the adhesion ability of the product to drop sharply, and the product cannot be reused after washing.

Claims

1. A preparation method of a highly adhesive sterile hydrogel patch, characterized in that, The highly adhesive sterile hydrogel patch has a three-layer structure, with a gel layer in the middle, a PE-type release film on the upper layer, and a PE plastic sheet on the lower layer. The preparation method includes the following steps: S1: Add polyvinyl alcohol, glycerol, and tartaric acid to water, heat and stir to obtain a mixed aqueous solution, denoted as the first component; S2: Add sodium polyacrylate, polyvinylpyrrolidone, antioxidant, and crosslinking regulator to glycerol and 1,4-butanediol, and stir until a homogeneous solution is formed, denoted as the second component; S3: Mix the first component and the second component liquids, and stir under vacuum to obtain a preliminary colloid; S4: Uniformly coat the preliminary colloid on the PE plastic sheet to obtain a gel layer, and attach a PE-type release film to the gel layer through a coater; S5: Cut and bag; S6: Perform 60 γ-ray irradiation forming of Co to obtain a highly adhesive sterile hydrogel patch; Among them, by mass fraction, the addition amount of polyvinyl alcohol is 5-7 parts, the addition amount of water is 40-59 parts, the total addition amount of glycerol is 25-35 parts, the addition amount of sodium polyacrylate is 1-2 parts, the addition amount of polyvinylpyrrolidone is 4-7 parts, the addition amount of antioxidant is 0.0075-0.015 parts, and the addition amount of 1,4-butanediol is 5-7 parts; The mass ratio of the sodium polyacrylate, crosslinking regulator, and tartaric acid is 1.5:(0.13-0.2):(0.04-0.06).

2. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, characterized in that, The mass ratio of the polyvinyl alcohol and polyvinylpyrrolidone is 1:(0.8-1).

3. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, characterized in that, The antioxidant is composed of butylated hydroxyanisole and citric acid, and the mass ratio of butylated hydroxyanisole and citric acid is (1.8-2.2):

1.

4. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, characterized in that, The crosslinking regulator is composed of aluminum glycinate and disodium edetate, and the mass ratio of aluminum glycinate and disodium edetate is (3-3.5):

1.

5. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, characterized in that, In the step S2, by mass fraction, the addition amount of glycerol is 10-20 parts.

6. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, wherein, The mass ratio of the total addition amount of glycerol to the addition amount of 1,4-butanediol is 5:(0.8-1.2).

7. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, wherein, In the step S1, the stirring temperature is 85-95 °C.

8. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, wherein, In the step S4, the thickness of the gel layer is 1.9-2.1 mm, the thickness of the PE plastic sheet is 200-250 μm, and the thickness of the PE-type release film is 50-60 μm.

9. The preparation method of the highly adhesive sterile hydrogel patch according to claim 1, wherein In the step S6, 60 The γ-ray irradiation dose of Co is 15 - 30 kGy.

10. A highly adhesive sterile hydrogel patch, characterized in that, Prepared by the preparation method of the highly adhesive sterile hydrogel patch according to any one of claims 1-9.

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