Composition and preparation method based on the properties of jujube family plants in replenishing qi and blood and improving sleep.

Abstract

This invention relates to the field of food, medicine, and health products technology, and particularly to a composition based on jujube plants that has the effects of replenishing qi and blood, improving sleep, and its preparation method. The composition includes jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, saffron extract, and other medicinal and edible ingredients. With jujube extract as the core, and in combination with collagen peptides, pomegranate concentrate, saffron, and spearmint extracts, it achieves integrated health intervention through multi-target action, replenishing qi and blood, improving sleep, and repairing skin.

Description

Technical Field

[0001] This invention relates to the field of food, medicine and health products technology, and in particular to a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep, and its preparation method. Background Technology

[0002] Qi and blood originate from the internal organs and circulate through the meridians and blood vessels. Qi is the commander of blood, and blood is the mother of qi; the two are mutually coordinated and interdependent. In Traditional Chinese Medicine (TCM), qi and blood are considered key factors in maintaining healthy skin. When the body's qi and blood are insufficient, the skin suffers. Qi and blood nourish the skin, maintaining its elasticity and radiance. If qi and blood are insufficient, the skin loses these characteristics, becoming dull, dry, and rough. Furthermore, insufficient qi and blood can also lead to pigmentation and age spots. Women with qi and blood deficiency often have a sallow complexion and may even develop dark yellow spots. Women with sufficient qi and blood typically have healthy, radiant, and elastic skin.

[0003] With the fast pace of life and high work pressure, mental stress, anxiety, and excessive mental exertion can all lead to dysfunction of the brain's nervous system, causing blood stasis and insomnia. Insufficient sleep leads to endocrine imbalance and impaired blood circulation, increasing cortisol levels, inhibiting collagen synthesis, damaging the skin barrier, and inducing problems such as dullness, dryness, sagging, and dark circles, accelerating aging. Endocrine disorders affect blood circulation and skin metabolism and repair, leading to insufficient skin nourishment, abnormal sebum secretion, and impaired barrier function, further accelerating aging. Long-term blood and qi deficiency can cause the skin to fall into a state of "nourishment depletion," resulting in a sallow and dull complexion, accelerated formation of fine lines and wrinkles, and a haggard and aged appearance. Once the skin barrier function declines, it becomes difficult to repair itself, and may even develop chronic inflammation, accelerating skin aging.

[0004] CN118490783A discloses a traditional Chinese medicine formula for improving sleep by nourishing both qi and blood, relating to the field of traditional Chinese medicine technology. This invention includes yam, polygonatum, wolfberry, longan, angelica, and maca, with the following weight components: 20g yam, 10g polygonatum, 10g wolfberry, 5g longan, 8g angelica, and 5g maca. By adding yam, polygonatum, wolfberry, and longan, this invention can compensate for deficiencies in different organs, thereby achieving a calming and intellect-enhancing effect. It has stable efficacy, nourishing blood, regulating menstruation, and replenishing blood, thus regulating the body's qi and blood balance and helping to improve sleep quality. CN109966375A discloses a health product for tonifying the kidneys, calming the mind, nourishing qi and blood, and improving sleep, and its preparation method. The raw materials, by weight, are as follows: 100g donkey-hide gelatin, 80g American ginseng, 80g longan pulp, 50g wolfberry, 50g angelica, 50g red dates, and 2.5g ferrous lactate. In this formula, donkey-hide gelatin nourishes blood and liver, and replenishes yin; American ginseng is a precious traditional Chinese medicine that gently replenishes qi and yin, enhancing immune function; longan pulp benefits the spleen and replenishes blood; goji berries nourish the liver and kidneys, and benefit essence and eyesight; angelica has the effect of promoting blood circulation and replenishing blood, enhancing immunity; and red dates nourish the spleen and stomach, and replenish qi and generate fluids. Ferrous lactate supplements trace elements and enhances immune function. All of the solutions reported in these patent documents have a bitter taste that affects the palatability, and their efficacy needs improvement.

[0005] Therefore, this application provides a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep, and a method for preparing the same. Summary of the Invention

[0006] In view of the above-mentioned deficiencies in the prior art, the technical problem to be solved by the present invention is to provide a composition based on jujube plants that has the effects of replenishing qi and blood and improving sleep, and its preparation method. The composition uses a mixture of jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, and saffron extract. This composition does not contain any Western medicines, and all the ingredients are substances that can be used as both food and medicine. The substances interact with each other to improve health issues through multiple pathways. In this invention, the synergistic effects of saffron and spearmint extracts enhance sleep quality, deeply repairing and nourishing the skin and restoring qi and blood during sleep. Pomegranate concentrate is used to bidirectionally regulate hormone levels and restore the body's own hormone stability. Jujube extract and hemoglobin polypeptides provide dual replenishment of qi and blood, fundamentally improving qi and blood problems.

[0007] To achieve the above objectives, the present invention provides a composition based on jujube plants that has the effects of replenishing qi and blood and improving sleep, characterized by comprising the following raw materials: jujube extract, collagen peptide, angelica powder, blood protein polypeptide, pomegranate concentrate powder, spearmint extract, and saffron extract.

[0008] Furthermore, a composition based on jujube family plants that have the effects of replenishing qi and blood and improving sleep includes the following ingredients:

[0009] Jujube extract 70-90 parts by weight, collagen peptide 5-15 parts by weight, angelica powder 1-5 parts by weight, blood protein polypeptide 3-10 parts by weight, pomegranate concentrate powder 2-8 parts by weight, spearmint extract 1-5 parts by weight, saffron extract 1-5 parts by weight.

[0010] Jujube extract enhances hematopoietic function, improves blood supply, promotes bone marrow stem cell regeneration, and increases myocardial blood supply, thereby increasing blood volume from the source. It also boosts immunity, restores health, enhances the body's immune response, and creates a favorable environment for the generation and flow of qi and blood. Furthermore, it nourishes qi and blood, as jujubes invigorate the spleen and stomach, replenish qi and generate fluids, regulate the body's defenses, and detoxify. It treats deficiency of qi, blood, and body fluids, disharmony of the body's defenses, and palpitations. The advanced CO2 low-temperature supercritical extraction process is solvent-free and process residue-free, ensuring 100% natural purity and avoiding byproducts that may be introduced during prolonged high-temperature extraction. It also highly extracts bioactive substances (cAMP). Jujube extract contains jujube-cyclic adenosine monophosphate (cAMP), with a cAMP content of 15 mg / 100g extract. CcAMP is an important substance in human cells involved in regulating metabolism and biological functions. It plays a crucial role in repairing, activating, and regulating brain cell function, converting short-term memory into long-term memory, relieving brain cell fatigue, and delaying brain cell aging.

[0011] Collagen is a major component of the dermis, accounting for up to 75% of the skin. It acts like a "skin scaffold," maintaining skin elasticity, firmness, and hydration. Supplementing with collagen helps increase skin thickness, improve blood microcirculation, and give the skin a rosy and radiant glow. Collagen works synergistically with iron and vitamin C to enhance hematopoietic function. Iron is a key element in hematopoiesis, and collagen peptides can promote iron absorption and utilization, increase red blood cell production, and improve anemia. Vitamin C promotes collagen synthesis while also enhancing blood circulation, making the skin firmer, more elastic, and more radiant.

[0012] The phytochemicals derived from ESTROBAL@pomegranate can act similarly to selective estrogen receptor modulators (SERMs). When estrogen levels are low, ESTROBAL pomegranate concentrate occupies estrogen receptors, exerting a weak estrogenic effect and thus increasing estrogen levels, treating hypoestrogenism. When estrogen levels are high, ESTROBAL pomegranate concentrate competes with endogenous estrogen for receptor sites, preventing estrogen from binding to receptors and effectively weakening the target cell response to estrogen, thus exhibiting an anti-estrogenic effect and lowering hormone levels. ESTROBAL@pomegranate concentrate restores estrogen balance through bidirectional regulation. Pomegranate extract contains pomegranate flavonoids and other plant-active substances that can supplement estrogen, activate ovarian cells, and prevent premature ovarian failure.

[0013] Spearmint extract contains various polyphenols such as salvianolic acid, shikonin, and rosmarinic acid, which can inhibit cholinesterase activity, ensuring the transmission of memory information and enhancing memory. Salvianolic acid and rosmarinic acid in spearmint extract can act on neurotransmitters in the brain that affect mood, relieving negative emotions, promoting sleep, and improving sleep quality. The various polyphenols in spearmint extract eliminate brain inflammation, relieve brain fatigue, and enhance brain activity. The natural polyphenolic antioxidants in spearmint stimulate and promote neuronal regeneration; the more neurons, the faster the signal transmission.

[0014] Saffron contains various natural active ingredients, including crocin, crocin, crocin acid, crocin glycosides, and other derivatives, which, under the influence of B vitamins, synthesize 5-HTP, which can help stabilize mood and reduce anxiety. Saffron is rich in tryptophan, which can be synthesized into melatonin in the body, improving sleep quality by regulating the body's circadian rhythm. Melatonin, an amine hormone secreted by the pineal gland in the brain, does not itself inhibit central nervous system excitation or have a sedative-hypnotic effect; it primarily improves sleep quality by regulating the body's circadian rhythm.

[0015] Angelica dahurica has a pungent taste and warm properties. It enters the stomach, large intestine, and lung meridians and has the functions of relieving exterior syndromes and dispelling cold, dispelling wind and relieving pain, clearing nasal passages, drying dampness and stopping leukorrhea, and reducing swelling and draining pus.

[0016] Blood protein polypeptides are absorbed in the form of small molecule peptides, with an absorption rate that is about 5-10 times higher than that of traditional iron supplements. They can improve blood and qi deficiency and have the effect of anti-aging from the root.

[0017] This invention utilizes saffron and spearmint extracts, among other active ingredients, to synergistically improve sleep quality. While sleeping, it deeply repairs and nourishes the skin, restoring blood and energy. It also employs concentrated pomegranate powder to bidirectionally regulate hormone levels, restoring the body's own hormonal balance. Furthermore, it uses jujube extract and blood protein peptides for dual replenishment of qi and blood, fundamentally improving blood and energy issues.

[0018] This invention employs a mixture of jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, and saffron extract. This composition contains no Western medicine and consists entirely of substances that are both medicinal and edible. In terms of replenishing qi and blood, the components synergistically promote hematopoietic function and nutrient absorption, improve qi and blood deficiency, regulate endocrine function, alleviate health problems caused by hormonal imbalances, improve nerve function, stabilize neurotransmitter balance, reduce brain fatigue, significantly improve sleep quality, and prolong deep sleep time. Antioxidant components synergistically delay cell aging, enhance skin elasticity and barrier function, and simultaneously activate immune cell activity, constructing multiple defense mechanisms. Ultimately, it effectively provides comprehensive enhancement from multiple aspects, including replenishing qi and blood, regulating endocrine function, improving nerve function, delaying aging, and enhancing immunity.

[0019] This invention also discloses a method for preparing a composition based on jujube plants that has the effects of replenishing qi and blood and improving sleep, comprising the following steps: mixing jujube extract, collagen peptide, angelica powder, hemoglobin polypeptide, pomegranate concentrate powder, spearmint extract, and saffron extract evenly, and conditioning and drying with steam to obtain the composition.

[0020] Small molecule peptides are susceptible to various influences, especially oxidation, which reduces their biological activity and makes them easily degraded by proteases in the gastrointestinal tract. However, spray drying is the most widely used method in the food and health product industries. Drying small molecule peptides using methods like spray drying easily leads to oxidation and degradation. Traditional Chinese medicine extracts contain a large number of active ingredients, but these ingredients are easily affected by the external environment, and their bitter taste also affects the palatability. This invention, based on the above, introduces modified chitosan and gummed protein to effectively improve the problems of peptide oxidation and degradation, as well as the susceptibility of active ingredients in extracts to external environmental influences, and improves the palatability, thereby improving sleep quality, replenishing qi and blood, and enhancing immunity.

[0021] Peach gum is a polysaccharide rich in nutrients and has excellent immunomodulatory effects. It also possesses good emulsifying and stability properties. Egg white protein contains amino acid composition and bioactive peptide components. In this invention, peach gum is used to treat egg white protein, which effectively enhances immunity and provides nutrition while exhibiting excellent emulsifying properties. Its interaction with modified chitosan mitigates the degradation and oxidation of active ingredients, while also improving taste. Furthermore, this invention uses linoleic acid and citric acid to treat chitosan, making it amphiphilic. This allows for self-assembly through intermolecular or intramolecular interactions and interaction with peach gum-modified egg white protein, effectively improving sleep, replenishing qi and blood, enhancing immunity, and supplementing nutrients.

[0022] A further preferred embodiment of a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following raw materials:

[0023] Jujube extract 70-90 parts by weight, collagen peptide 5-15 parts by weight, angelica powder 1-5 parts by weight, hemoprotein polypeptide 3-10 parts by weight, pomegranate concentrate powder 2-8 parts by weight, spearmint extract 1-5 parts by weight, saffron extract 1-5 parts by weight, modified chitosan 10-25 parts by weight, and guar gum modified egg white protein 5-15 parts by weight.

[0024] The modified chitosan is prepared as follows: chitosan is added to a 50wt% aqueous acetic acid solution and mixed evenly to obtain a chitosan solution with a concentration of 1-2wt%; linoleic acid is added to anhydrous ethanol and mixed evenly to obtain a linoleic acid solution with a concentration of 0.1-0.5wt%; citric acid is added to water and mixed evenly to obtain a citric acid solution with a concentration of 0.05-0.2wt%; 0.3-0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and 0.3-0.6 parts by weight of N-hydroxysuccinimide (NHS) are added to 30-50 parts by weight of a 50wt% aqueous ethanol solution and mixed evenly to obtain a mixed solution; then the mixed solution, linoleic acid solution, and citric acid solution are added to the chitosan solution and mixed evenly, and stirred at room temperature for 24 hours. After the reaction is completed, the mixture is dialyzed with water for two days, and the dialysate is freeze-dried to obtain the modified chitosan.

[0025] The volume ratio of the mixed solution, linoleic acid solution, citric acid solution, and chitosan solution is 30-60 mL: 30-60 mL: 30-60 mL: 30-60 mL;

[0026] The preparation method of the peach gum modified egg white protein is as follows: peach gum is added to water and mixed evenly, heated to 60-70℃ and soaked for 1-3 hours, then pulped, the pulp is ultrasonically treated, and kept at 50-60℃ to obtain a peach gum solution; the peach gum solution and egg white protein are mixed evenly and heated to 70-80℃ for 6-10 hours to obtain peach gum modified egg white protein;

[0027] The mass ratio of peach gum to water is 1:8-10; the mass ratio of peach gum solution to egg white protein is 4:0.5-2.

[0028] The ultrasonic treatment conditions are 200-400W ultrasonic power and 45-65℃ for 20-40 minutes.

[0029] The present invention also discloses a method for preparing a composition based on jujube plants that has the effects of replenishing qi and blood and improving sleep.

[0030] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0031] The active ingredients are obtained by mixing jujube extract, collagen peptide, angelica powder, hemoprotein peptide, pomegranate concentrate, spearmint extract, and saffron extract evenly, and then conditioning and drying with steam.

[0032] Modified chitosan was added to water and mixed evenly. Emulsifier was added and mixed evenly. Active ingredient was added and mixed evenly. Peach gum-modified egg white protein and 1-2 wt% calcium chloride solution were added. The mixture was cured at room temperature for 4-6 hours. After filtration and drying, the composition was obtained.

[0033] The compositions provided by this invention can be taken directly as medicine or prepared into desired formulations by adding pharmaceutically acceptable excipients using conventional processes. For example, they can be formulated into oral medications in the form of commonly used solid dosage forms such as tablets (dispersible tablets, effervescent tablets, orally disintegrating tablets, lozenges, chewable tablets), capsules (hard capsules, soft capsules), granules, pills (drop pills), and powders, or into oral medications in the form of liquid dosage forms such as syrups and oral liquids. Therefore, in addition to the active ingredient, the composition can also contain pharmaceutically acceptable excipients.

[0034] The beneficial effects of this invention are:

[0035] Compared with existing technologies, this invention uses a mixture of jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, and saffron extract. This composition does not contain Western medicine, and all the ingredients are both medicinal and edible. The substances interact with each other to improve health issues through multiple pathways. The saffron and spearmint extracts work synergistically to improve sleep quality, deeply repairing and nourishing the skin and restoring blood circulation during sleep. Pomegranate concentrate regulates hormone levels bidirectionally, restoring the body's own hormone balance. Jujube extract and hemoglobin polypeptides provide dual replenishment of qi and blood, fundamentally improving blood circulation problems. Detailed Implementation

[0036] The endpoints and any values ​​of the ranges disclosed in this invention are not limited to the precise ranges or values, and these ranges or values ​​should be understood to include values ​​close to these ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be considered as specifically disclosed in this invention.

[0037] Description of some of the raw materials used in the embodiments of this invention:

[0038] The method for preparing the jujube extract used in the examples is the same as that in Example 1 of patent CN103623080B.

[0039] The pomegranate concentrate used in the examples is Pomegranate concentrate powder is a commercially available product, purchased from Miaopinyuan.

[0040] The preparation method of spearmint extract used in the examples is as follows: Spearmint is dried, pulverized and passed through an 80-mesh sieve to obtain spearmint powder; the spearmint powder is added to a 50wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:40mL and mixed evenly, and extracted at a power of 100W and a temperature of 60℃ for 60min, and the extraction is repeated 3 times. The filtrate and residue are collected by centrifugation; the residue is added to a 75wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:40mL and mixed evenly, and extracted at a power of 200W and a temperature of 70℃ for 60min, and the extraction is repeated 3 times. The filtrate is collected by centrifugation, and all filtrates are combined, concentrated and dried to obtain spearmint extract.

[0041] The preparation method of saffron extract used in the examples is as follows: saffron is dried, pulverized, and passed through an 80-mesh sieve to obtain saffron powder; the saffron powder is added to water and mixed evenly, and a compound enzyme (trypsin (250,000 U / g) and alkaline protease (200,000 U / g) mixed at a mass ratio of 1:1) is added, and the mixture is heated to 38°C for enzymatic hydrolysis for 3 hours. After the enzymatic hydrolysis is completed, the enzyme is inactivated, filtered, and filtrate and filter residue are obtained. The material-to-liquid ratio of saffron powder to water is 1 g: 40 mL, and the amount of compound enzyme added is 5 wt% of the saffron powder; the filter residue is added to 75 wt% ethanol aqueous solution at a material-to-liquid ratio of 1 g: 40 mL and mixed evenly. The mixture is extracted at a power of 200 W and a temperature of 60°C for 60 min, and extracted 3 times. The filtrate is collected by centrifugation, and all filtrates are combined, concentrated, and dried to obtain saffron extract.

[0042] The method for preparing Angelica dahurica powder used in the examples is to dry Angelica dahurica, pulverize it and pass it through a 100-mesh sieve to obtain Angelica dahurica powder.

[0043] Other raw materials not mentioned are all common raw materials. The above content is only for the purpose of illustrating the present invention and should not be construed as a strict limitation of the present invention. Those skilled in the art can directly purchase the same / similar raw materials from the market or prepare them themselves.

[0044] The technical solutions of the present invention will be clearly and completely described below with reference to specific embodiments. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0045] Example 1

[0046] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0047] 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica powder, 8 parts by weight of hemoprotein peptide, 6 parts by weight of pomegranate concentrate, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract were mixed evenly, and the mixture was conditioned and dried by steam to obtain the composition.

[0048] Example 2

[0049] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0050] 90 parts by weight of jujube extract, 15 parts by weight of collagen peptide, 1 part by weight of angelica powder, 10 parts by weight of hemoprotein polypeptide, 3 parts by weight of pomegranate concentrate, 1 part by weight of spearmint extract, and 2 parts by weight of saffron extract were mixed evenly and then conditioned and dried with steam to obtain the composition.

[0051] Example 3

[0052] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0053] 70 parts by weight of jujube extract, 5 parts by weight of collagen peptide, 5 parts by weight of angelica powder, 3 parts by weight of hemoprotein polypeptide, 2 parts by weight of pomegranate concentrate, 3 parts by weight of spearmint extract, and 1 part by weight of saffron extract were mixed evenly and then conditioned and dried with steam to obtain the composition.

[0054] Example 4

[0055] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0056] 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica powder, 8 parts by weight of hemoprotein peptide, 6 parts by weight of pomegranate concentrate, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract were mixed evenly, and the active ingredients were obtained by steam conditioning and drying.

[0057] 12 parts by weight of modified chitosan were added to 100 parts by weight of water and mixed evenly. 4 parts by weight of Tween 80 were added and mixed evenly. 10 parts by weight of active ingredient were added and mixed evenly. 7 parts by weight of gum-modified egg white protein and 10 parts by weight of 2wt% calcium chloride solution were added. The mixture was cured at room temperature for 4 hours, filtered, and dried to obtain the composition.

[0058] The modified chitosan is prepared as follows: chitosan is added to a 50wt% acetic acid aqueous solution and mixed evenly to obtain a 1wt% chitosan solution; linoleic acid is added to anhydrous ethanol and mixed evenly to obtain a 0.3wt% linoleic acid solution; citric acid is added to water and mixed evenly to obtain a 0.15wt% citric acid solution; 0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.6 parts by weight of N-hydroxysuccinimide are added to 50 parts by weight of a 50wt% ethanol aqueous solution and mixed evenly to obtain a mixed solution; then the mixed solution, linoleic acid solution, and citric acid solution are added to the chitosan solution and mixed evenly, and stirred at room temperature for 24 hours. After the reaction, the mixture is dialyzed with water for two days (molecular weight cutoff 7000 Da), and the dialysate is freeze-dried to obtain modified chitosan; wherein the volume ratio of the mixed solution, linoleic acid solution, citric acid solution, and chitosan solution is 50mL:50mL:50mL:50mL.

[0059] The preparation method of the gummed modified egg white protein is as follows:

[0060] Peach gum was mixed evenly with water, heated to 70℃ and soaked for 2 hours, then pulped. The pulp was treated with ultrasonic power 200W and temperature 55℃ for 40 minutes and kept at 55℃ to obtain peach gum solution. The peach gum solution and egg white were mixed evenly and heated to 80℃ for 8 hours to obtain peach gum-modified egg white protein. The mass ratio of peach gum to water was 1:10; the mass ratio of peach gum solution to egg white protein was 4:2.

[0061] Example 5

[0062] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0063] 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica powder, 8 parts by weight of hemoprotein peptide, 6 parts by weight of pomegranate concentrate, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract were mixed evenly, and the active ingredients were obtained by steam conditioning and drying.

[0064] 12 parts by weight of chitosan were added to 100 parts by weight of water and mixed evenly. 4 parts by weight of Tween 80 were added and mixed evenly. 10 parts by weight of active ingredient were added and mixed evenly. 7 parts by weight of gum-modified egg white protein and 10 parts by weight of 2 wt% calcium chloride solution were added. The mixture was cured at room temperature for 4 hours, filtered, and dried to obtain the composition.

[0065] The preparation method of the gummed modified egg white protein is as follows:

[0066] Peach gum was mixed evenly with water, heated to 70℃ and soaked for 2 hours, then pulped. The pulp was treated with ultrasonic power 200W and temperature 55℃ for 40 minutes and kept at 55℃ to obtain peach gum solution. The peach gum solution and egg white were mixed evenly and heated to 80℃ for 8 hours to obtain peach gum-modified egg white protein. The mass ratio of peach gum to water was 1:10; the mass ratio of peach gum solution to egg white protein was 4:2.

[0067] Example 6

[0068] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0069] 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica powder, 8 parts by weight of hemoprotein peptide, 6 parts by weight of pomegranate concentrate, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract were mixed evenly, and the active ingredients were obtained by steam conditioning and drying.

[0070] 12 parts by weight of modified chitosan were added to 100 parts by weight of water and mixed evenly. 4 parts by weight of Tween 80 were added and mixed evenly. 10 parts by weight of active ingredient were added and mixed evenly. 7 parts by weight of egg white protein and 10 parts by weight of 2wt% calcium chloride solution were added. The mixture was cured at room temperature for 4 hours, filtered, and dried to obtain the composition.

[0071] The modified chitosan is prepared as follows: chitosan is added to a 50wt% acetic acid aqueous solution and mixed evenly to obtain a 1wt% chitosan solution; linoleic acid is added to anhydrous ethanol and mixed evenly to obtain a 0.3wt% linoleic acid solution; citric acid is added to water and mixed evenly to obtain a 0.15wt% citric acid solution; 0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.6 parts by weight of N-hydroxysuccinimide are added to 50 parts by weight of a 50wt% ethanol aqueous solution and mixed evenly to obtain a mixed solution; then the mixed solution, linoleic acid solution, and citric acid solution are added to the chitosan solution and mixed evenly, and stirred at room temperature for 24 hours. After the reaction is completed, the mixture is dialyzed with water for two days (molecular weight cutoff 7000 Da), and the dialysate is freeze-dried to obtain modified chitosan; wherein the volume ratio of the mixed solution, linoleic acid solution, citric acid solution, and chitosan solution is 50mL:50mL:50mL:50mL.

[0072] Example 7

[0073] A method for preparing a composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep includes the following steps:

[0074] 82 parts by weight of jujube extract, 12 parts by weight of collagen peptide, 4 parts by weight of angelica powder, 8 parts by weight of hemoprotein peptide, 6 parts by weight of pomegranate concentrate, 5 parts by weight of spearmint extract, and 3 parts by weight of saffron extract were mixed evenly, and the active ingredients were obtained by steam conditioning and drying.

[0075] 12 parts by weight of chitosan were added to 100 parts by weight of water and mixed evenly. 4 parts by weight of Tween 80 were added and mixed evenly. 10 parts by weight of active ingredient were added and mixed evenly. 3.5 parts by weight of egg white protein, 3.5 parts by weight of peach gum, and 10 parts by weight of 2wt% calcium chloride solution were added. The mixture was cured at room temperature for 4 hours. After filtration and drying, the composition was obtained.

[0076] Test Example 1

[0077] Seventy experimental mice (weighing 20±2g, healthy males, clean grade) were selected and placed in a laboratory at a temperature of 22℃-25℃ and a relative humidity of 60%-80%. The mice were allowed free access to food and water for 5 days before the experiment began. The mice were randomly divided into 7 groups. In the model control group and experimental group, 0.2mL / 10g of blood was excised from the tail of each mouse on days 1, 3, 5, 7, and 9 of the modeling process (i.e., 0.2mL of blood was excised per 10g of mouse body weight). On days 2, 4, 6, and 8 of the modeling process, each mouse was injected intraperitoneally with cyclophosphamide at 60mg / kg, 40mg / kg, 40mg / kg, and 40mg / kg, respectively. The mice were fasted for 12 hours before cyclophosphamide administration, but allowed free access to water. The blank control group did not undergo tail bleeding. While the other groups received cyclophosphamide injections, the blank control group received only an intraperitoneal injection of the same volume of physiological saline. During the modeling process, the mice in the blank control group were fed normally, with no restrictions on food or water. The blank control group and the model control group were administered physiological saline (0.9wt%) at 0.3 mL / 10 g orally by gavage for 10 consecutive days. The experimental group was administered the combined composition (0.8 g / mL) at 0.3 mL / 10 g orally by gavage for 10 consecutive days. Two hours after the last administration, blood was collected from the tails of mice in each group. After anticoagulation and dilution, the peripheral blood erythrocyte (RBC) count, white blood cell (WBC) count, and platelet (PLT) count were measured using an automated blood cell counter.

[0078] Table 1. Experimental results of the composition for replenishing qi and nourishing blood.

[0079] <![CDATA[RBC content / (10 12 / L)]]> <![CDATA[WBC content / (10 9 / L)]]> <![CDATA[PLT content / (10 9 / L)]]> Blank control group 8.7 9.52 67.25 Model control group 4.75 5.25 41.38 Example 1 5.49 6.17 46.04 Example 4 7.61 8.34 62.13 Example 5 6.88 7.21 52.46 Example 6 7.13 7.80 57.09 Example 7 6.25 6.83 50.71

[0080] As shown in Table 1, the compositions prepared in the examples have excellent qi-tonifying and blood-nourishing effects. This invention uses a mixture of jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate powder, spearmint extract, and saffron extract. This composition does not contain Western medicine, and all the ingredients are both medicinal and edible. The substances interact with each other, improving health issues through multiple pathways. Based on the above, this invention introduces modified chitosan and gummed egg white protein, effectively improving the problems of easy oxidation and degradation of polypeptides and the susceptibility of active ingredients in the extracts to external environmental influences, thus improving taste and improving sleep quality, replenishing qi and blood, and enhancing immunity.

[0081] Peach gum is a polysaccharide rich in nutrients and has good immunomodulatory effects. It also has good emulsifying and stability properties. In this invention, peach gum is used to treat egg white protein, which can effectively improve immunity and provide nutrition. At the same time, it has a good emulsifying effect. It interacts with modified chitosan, which improves the problems of easy degradation and oxidation of active ingredients, and improves the taste. This invention uses linoleic acid and citric acid to treat chitosan, making chitosan amphiphilic. It can self-assemble through intermolecular or intramolecular interactions and interact with peach gum-modified egg white protein, which can effectively improve sleep, replenish qi and blood, and improve immunity and supplement nutrients.

[0082] Test Example 2

[0083] Laboratory mice weighing 22-25g, clean grade, half male and half female, were randomly divided into 6 groups of 10 mice each. The experimental environment was maintained at a temperature of 20-25℃ and a relative humidity of 60-70%. The mice were administered the composition prepared in the example via gavage at a dose of 100mg / kg. A blank control group was also provided, which was administered physiological saline via gavage. The sleep latency (time when the righting reflex disappeared) and sleep duration (time from the disappearance to the recovery of the righting reflex) of the mice in each group were observed and recorded.

[0084] Table 2. Experimental results of the composition improving sleep

[0085] Sleep latency / min Sleep duration / min Blank control group 6.40 12.06 Example 1 5.76 14.48 Example 4 3.51 21.57 Example 5 4.83 16.34 Example 6 4.12 18.22 Example 7 5.25 15.81

[0086] As shown in Table 2, the composition prepared in Example 4 significantly shortened the sleep latency and significantly prolonged the duration of sleep. Furthermore, the performance of Example 4 was significantly better than that of Examples 5-7. This may be because: the use of peach gum to treat egg white protein in this invention effectively improves immunity and provides nutrition, while also having a good emulsifying effect. Its interaction with modified chitosan improves the problems of easy degradation and oxidation of active ingredients, and also improves the taste. The use of linoleic acid and citric acid to treat chitosan in this invention makes it amphiphilic, allowing it to self-assemble through intermolecular or intramolecular interactions and interact with peach gum-modified egg white protein, effectively improving sleep, replenishing qi and blood, and simultaneously enhancing immunity and supplementing nutrients.

[0087] Test Example 3

[0088] The compositions prepared in the examples (recommended human dose 1g / person / day) were weighed out and added to the basal diet of rats at the recommended human dose of 0.5g / kg·bw / d for 30 consecutive days. Body weight and food intake were measured weekly, and weekly body weight and total food utilization were calculated. Daily observations were made for any signs of toxicity or death. At the end of the experiment, blood biochemistry and organ coefficients were observed, and pathological examinations were performed. Results: During the experiment, no abnormal changes were observed in organ weight or organ coefficients for any of the compositions prepared in the examples. Blood and biochemical indicators remained within normal ranges. Therefore, no pathological changes or harmful effects related to the test compositions were observed.

[0089] This invention employs a mixture of jujube extract, collagen peptides, angelica powder, hemoprotein polypeptides, pomegranate concentrate, spearmint extract, and saffron extract. This composition contains no Western medicine and consists entirely of substances that are both medicinal and edible. The interactions between these substances significantly enhance immunity, effectively improve sleep, and replenish qi and blood. The synergistic effect of saffron and spearmint extracts improves sleep quality, deeply repairs and nourishes the skin, and restores qi and blood during sleep. Pomegranate concentrate regulates hormone levels, restoring the body's own hormonal balance. Jujube extract and hemoprotein polypeptides provide dual replenishment of qi and blood, fundamentally improving qi and blood issues.

[0090] The preferred embodiments of the present invention have been described in detail above. It should be understood that those skilled in the art can make numerous modifications and variations based on the concept of the present invention without creative effort. Therefore, all technical solutions that can be obtained by those skilled in the art based on the concept of the present invention through logical analysis, reasoning, or limited experimentation on the basis of existing technology should be within the scope of protection defined by the claims.

Claims

1. A composition based on jujube family plants that has the effects of replenishing qi and blood and improving sleep, characterized in that, The ingredients include: 70-90 parts by weight of jujube extract, 5-15 parts by weight of collagen peptide, 1-5 parts by weight of angelica powder, 3-10 parts by weight of hemoprotein polypeptide, 2-8 parts by weight of pomegranate concentrate powder, 1-5 parts by weight of spearmint extract, 1-5 parts by weight of saffron extract, 10-25 parts by weight of modified chitosan, and 5-15 parts by weight of guar gum modified egg white protein. The modified chitosan is prepared as follows: chitosan is added to a 50wt% aqueous acetic acid solution and mixed evenly to obtain a chitosan solution with a concentration of 1-2wt%; linoleic acid is added to anhydrous ethanol and mixed evenly to obtain a linoleic acid solution with a concentration of 0.1-0.5wt%; citric acid is added to water and mixed evenly to obtain a citric acid solution with a concentration of 0.05-0.2wt%; 0.3-0.6 parts by weight of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide and 0.3-0.6 parts by weight of N-hydroxysuccinimide are added to 30-50 parts by weight of a 50wt% aqueous ethanol solution and mixed evenly to obtain a mixed solution; then the mixed solution, linoleic acid solution, and citric acid solution are added to the chitosan solution and mixed evenly, and stirred at room temperature for 24 hours. After the reaction is completed, the mixture is dialyzed with water for two days, the molecular weight cutoff is 7000 Da, and the dialysate is freeze-dried to obtain the modified chitosan. The golden thread jujube extract was prepared by CO2 low-temperature supercritical extraction process; The preparation method of the spearmint extract is as follows: Spearmint is dried and pulverized through an 80-mesh sieve to obtain spearmint powder; the spearmint powder is added to a 50wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:40mL and mixed evenly, and extracted at a power of 100W and a temperature of 60℃ for 60min, and the extraction is repeated 3 times; the filtrate and residue are collected by centrifugation; the residue is added to a 75wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:40mL and mixed evenly, and extracted at a power of 200W and a temperature of 70℃ for 60min, and the extraction is repeated 3 times; the filtrate is collected by centrifugation; all filtrates are combined, concentrated, and dried to obtain the spearmint extract; The preparation method of the saffron extract is as follows: saffron is dried, pulverized, and passed through an 80-mesh sieve to obtain saffron powder; the saffron powder is added to water and mixed evenly, and a compound enzyme is added, wherein trypsin 250,000 U / g and alkaline protease 200,000 U / g are mixed at a mass ratio of 1:1, heated to 38℃ for enzymatic hydrolysis for 3 hours, and the enzyme is inactivated after hydrolysis. The mixture is filtered to obtain filtrate and filter residue, wherein the material-to-liquid ratio of saffron powder to water is 1g:40mL, and the amount of compound enzyme added is 5wt% of saffron powder; the filter residue is added to 75wt% ethanol aqueous solution at a material-to-liquid ratio of 1g:40mL and mixed evenly, and extracted at a power of 200W and a temperature of 60℃ for 60 minutes, and extracted 3 times. The filtrate is collected by centrifugation, and all filtrates are combined, concentrated, and dried to obtain the saffron extract; The preparation method of the peach gum modified egg white protein is as follows: peach gum is added to water and mixed evenly, heated to 60-70℃ and soaked for 1-3 hours, then pulped, the pulp is ultrasonically treated, and kept at 50-60℃ to obtain a peach gum solution; the peach gum solution and egg white protein are mixed evenly and heated to 70-80℃ for 6-10 hours to obtain peach gum modified egg white protein.

2. The composition based on jujube family plants as described in claim 1, characterized in that: The composition is formulated into a preparation, which is a tablet, granule, capsule, pill, or oral liquid preparation.

3. A method for preparing a composition based on jujube family plants with qi-tonifying, blood-nourishing, and sleep-improving properties, as described in any one of claims 1-2, characterized in that, The process includes the following steps: mixing jujube extract, collagen peptides, angelica powder, hemoglobin polypeptides, pomegranate concentrate, spearmint extract, saffron extract, modified chitosan, and peach gum-modified egg white protein evenly, and then conditioning and drying with steam to obtain the composition.