Preparation method of stably-extracted microneedle eye patch with capsule wrapping and acupuncture slow release functions

Abstract

The invention discloses a preparation method of a microneedle eye patch with capsule wrapping and acupuncture slow release and stable extraction, and belongs to the technical field of medicine and cosmetology, the preparation method of the microneedle eye patch with capsule wrapping and acupuncture slow release and stable extraction comprises configuration equipment, the configuration equipment comprises an operation box, and a mounting seat is arranged at the inner bottom of the operation box; a micro-needle eye patch mold is clamped to the mounting base, a moving control assembly is fixedly mounted on the inner side face of the operation box, and a liquid preparation assembly is mounted on the moving control assembly. The risk that the micro-needle eye patch is in contact with harmful bacteria can be reduced, drugs used for micro-needle treatment are increased, the acupuncture slow-release effect is achieved, extra treatment does not need to be conducted on used micro-needles, and pollution to the environment is avoided.

Description

Technical Field

[0001] The present invention relates to the technical fields of medicine and beauty. More specifically, it relates to a preparation method of a micro-needle eye patch with stable extraction, which combines capsule encapsulation and acupuncture sustained release. Background Art

[0002] A micro-needle eye patch is a product that makes active ingredients such as hyaluronic acid into hard and tiny needle tips and attaches them to a medical adhesive patch. These tiny needle tips can penetrate the stratum corneum of the skin and deliver the active ingredients to the deep layer of the skin, so as to achieve effects such as removing eye wrinkles and moisturizing the skin.

[0003] Currently, in the use of common micro-needle eye patches, a micro metal needle needs to be used in cooperation. Moreover, the micro metal needle contains little or no medicine. During the use process, the presence of the metal needle increases the risk of the micro-needle eye patch coming into contact with harmful bacteria. At the same time, the used metal needle is not easy to handle.

[0004] Therefore, in view of this, the existing structure is studied and improved to provide a preparation method of a micro-needle eye patch with stable extraction, which combines capsule encapsulation and acupuncture sustained release, in order to achieve a more practical value. Summary of the Invention

[0005] 1. Technical Problems to be Solved

[0006] Aiming at the problems existing in the prior art, the purpose of the present invention is to provide a preparation method of a micro-needle eye patch with stable extraction, which combines capsule encapsulation and acupuncture sustained release. It can reduce the risk of the micro-needle eye patch coming into contact with harmful bacteria, increase the medicine used in micro-needle treatment, achieve the effect of acupuncture sustained release, and does not require additional treatment of the used micro-needles, nor will it cause pollution to the environment.

[0007] 2. Technical Solutions

[0008] To solve the above problems, the present invention adopts the following technical solutions.

[0009] A preparation method of a micro-needle eye patch with stable extraction, which combines capsule encapsulation and acupuncture sustained release, includes a configuration device. The configuration device includes an operation box. An installation seat is arranged at the inner bottom of the operation box, and a micro-needle eye patch mold is snap-fitted on the installation seat. A movement control component is fixedly installed on the inner side surface of the operation box, and a liquid dispensing component is installed on the movement control component;

[0010] Using the above configuration device, a freeze dryer, and a vacuum dryer to prepare the micro-needle eye patch, the specific steps are as follows:

[0011] Step 1: Prepare the mold and install it: Prepare a micro-needle eye patch mold and place it on the installation seat. The installation seat is installed in the operation box;

[0012] Step 2: Prepare the tip liquid and inject it: Inject the tip liquid into the micro-needle patch mold through the liquid preparation component;

[0013] Step 3: Freeze-dry and melt the tip liquid: After the tip liquid is spread flat in the micro-needle patch mold, send it into the freeze-dryer to solidify it, and then heat it up to melt it. Repeat the processes of solidification and heating and melting multiple times to make the tip liquid completely fill the inverted conical cavity of the mold;

[0014] Step 4: Prepare the base liquid: Slowly pour the base liquid along the edge into the micro-needle patch mold through the liquid preparation component;

[0015] Step 5: Dry and form the micro-needle patch: After drying under reduced pressure and vacuum, take out the large patch from the micro-needle patch mold, and process it to obtain the final micro-needle patch product.

[0016] Further, the micro-needle patch mold is a silicone mold, and a number of inverted conical cavities are provided on its inner bottom.

[0017] Further, the bottom end of the mounting seat is an iron block with a T-shaped structure, a T-shaped groove is opened at the bottom of the operation box, and a magnet is arranged inside the T-shaped groove.

[0018] Further, four insertion posts are fixed at the top end of the mounting seat, the outside of the micro-needle patch mold is wrapped with a metal frame, and insertion holes slidably connected with the insertion posts are opened on the metal frame.

[0019] Further, the movement control component includes a horizontal linear module, both ends of the horizontal linear module are fixed on the inner wall of the operation box, a lifting device is fixedly installed on the moving part of the horizontal linear module, a vertical linear module is fixedly installed on the output part of the lifting device, and the liquid preparation component is installed at the position of the moving part of the vertical linear module.

[0020] Further, the liquid preparation component includes a double-layer platform, three liquid injection tanks are fixed at the top end of the upper layer of the double-layer platform, three of the interfaces of the four-way pipe are respectively connected to the output ports of the three liquid injection tanks, the last interface of the four-way pipe is connected with a hose through a flange, the hose passes through the double-layer platform, and is connected with an injection head through a flange;

[0021] A deflection structure is arranged at the top end of the lower layer of the double-layer platform, and the deflection structure controls the rotation angle of the injection head.

[0022] Further, the interiors of the three liquid injection tanks store tip liquid, cleaning water, and base liquid respectively.

[0023] Further, the deflection structure includes a hollow skeleton, a ball sleeve is fixed in the middle of the hollow skeleton, a sphere is movably connected to the inside of the ball sleeve through a bearing, the sphere is fixed to the outside of the injection head, and the central axis of the sphere coincides with the central axis of the injection head.

[0024] Further, two arc-shaped parallel clamping strips are movably connected to the inner side of the hollowed-out framework through bearings. The two arc-shaped parallel clamping strips are arranged perpendicular to each other, and the injection head is located at the clamping opening formed by the two arc-shaped parallel clamping strips.

[0025] Two small motors are fixed on the hollowed-out framework, and the output shafts of the small motors are drivingly connected to the corresponding arc-shaped parallel clamping strips through couplings.

[0026] Further, after the micro-needle patch, the tip part of the micro-needle patch contains a hyaluronic acid mixture, hydroxypropyl methylcellulose, polyvinyl alcohol, and phospholipid components.

[0027] The base part of the micro-needle patch is composed of at least one of polyvinyl alcohol and its derivatives, polyvinylpyrrolidone and its derivatives, hyaluronic acid or its salts, lactose, sorbitol, dextran, trehalose, and sucrose.

[0028] 3. Beneficial effects

[0029] Compared with the prior art, the advantages of the present invention are as follows:

[0030] In this solution, through the preparation process of the micro-needle patch, the tip liquid forms the tip structure of the micro-needle and forms a stable capsule structure, thereby replacing the metal needle. Moreover, the tip part contains more drugs, reducing the risk of the micro-needle patch contacting harmful bacteria during use.

[0031] At the same time, the medicinal components in the tip part can be slowly released into the subcutaneous tissue to achieve the effect of slow release of acupuncture.

[0032] After the micro-needle treatment is completed, since all the components of the micro-needle patch are biodegradable, they can be absorbed by the skin or excreted from the body after use, without the need for additional treatment and without causing environmental pollution. Description of the drawings

[0033] Figure 1 It is a three-dimensional structural schematic diagram of the configuration device in the present invention;

[0034] Figure 2 It is a three-dimensional structural schematic diagram of the operation box and the mobile control component in the present invention;

[0035] Figure 3 It is a three-dimensional structural schematic diagram of the mounting seat and the micro-needle patch mold in the present invention;

[0036] Figure 4 It is a three-dimensional structural schematic diagram of the liquid preparation component in the present invention;

[0037] Figure 5 It is a planar structural schematic diagram of the liquid preparation component in the present invention;

[0038] Figure 6Schematic diagram of the three-dimensional structure of the biasing structure in the present invention;

[0039] Figure 7 Schematic flow chart of the preparation of the micro-needle eye patch in the present invention.

[0040] Explanation of the reference numerals in the figure:

[0041] 1. Working box; 101. T-shaped groove;

[0042] 2. Mounting seat; 201. Insertion post;

[0043] 3. Micro-needle eye patch mold; 301. Inverted conical cavity; 302. Metal frame;

[0044] 4. Movement control component; 401. Horizontal linear module; 402. Lifting device; 403. Longitudinal linear module;

[0045] 5. Liquid dispensing component; 501. Double-layer platform; 502. Liquid injection tank; 503. Four-way pipe; 504. Hose; 505. Injection head;

[0046] 506. Biasing structure; 5061. Hollowed-out skeleton; 5062. Ball sleeve; 5063. Sphere; 5064. Arc-shaped parallel clamping strip; 5065. Small motor. Specific implementation manners

[0047] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention; obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts shall fall within the protection scope of the present invention.

[0048] Embodiment 1:

[0049] Please refer to Figure 1 - Figure 6 , a preparation method of a micro-needle eye patch with stable extraction that combines capsule encapsulation and acupuncture sustained release. The preparation equipment includes a working box 1. An installation seat 2 is arranged at the inner bottom of the working box 1. A micro-needle eye patch mold 3 is clamped on the installation seat 2. A movement control component 4 is fixedly installed on the inner side surface of the working box 1. A liquid dispensing component 5 is installed on the movement control component 4;

[0050] Embodiment 2:

[0051] Based on the above Embodiment 1, a further description is made.

[0052] Please refer to Figure 1 , Figure 3, the micro - acupuncture patch mold 3 is a silicone mold, and there are several inverted - conical cavities 301 provided on its inner bottom.

[0053] After injecting the needle - tip liquid, the needle - tip liquid can form a needle - tip structure at the inverted - conical cavity 301, and then after freezing and drying, it is finally solidified into a needle - tip structure.

[0054] Refer to Figure 1 、 Figure 2 、 Figure 3 , specifically, the bottom end of the mounting seat 2 is an iron block with a T - shaped structure, a T - shaped groove 101 is opened at the bottom of the operation box 1, and a magnet is arranged inside the T - shaped groove 101.

[0055] By sliding the T - shaped structure into the T - shaped groove 101 and fixing it by magnetic attraction, the stable installation between the mounting seat 2 and the operation box 1 can be facilitated.

[0056] Refer to Figure 1 、 Figure 3 , specifically, four plug posts 201 are fixed at the top end of the mounting seat 2, and a metal frame 302 is wrapped outside the micro - acupuncture patch mold 3, and jacks slidably connected to the plug posts 201 are opened on the metal frame 302.

[0057] By inserting the plug posts 201 into the jacks, the micro - acupuncture patch mold 3 can be placed on the mounting seat 2, and by using gravity, the relative stability between the micro - acupuncture patch mold 3 and the mounting seat 2 can be ensured.

[0058] Refer to Figure 1 、 Figure 2 , specifically, the movement control component 4 includes a horizontal linear module 401, both ends of the horizontal linear module 401 are fixed on the inner wall of the operation box 1, a lifting device 402 is fixedly installed on the moving part of the horizontal linear module 401, the lifting device 402 is a lifting motor and a load - bearing platform, the lifting motor is installed on the load - bearing platform, the load - bearing platform is installed at the position of the moving part of the horizontal linear module 401, this part is a common structure and will not be elaborated, a vertical linear module 403 is fixedly installed on the output part of the lifting device 402, and the liquid - dispensing component 5 is installed at the position of the moving part of the vertical linear module 403.

[0059] In the movement control component 4:

[0060] The horizontal linear module 401 controls the horizontal movement of the lifting device 402, the vertical linear module 403, and the liquid - dispensing component 5;

[0061] The lifting device 402 controls the up - and - down movement of the vertical linear module 403 and the liquid - dispensing component 5;

[0062] The vertical linear module 403 controls the longitudinal movement of the liquid - dispensing component 5;

[0063] Finally, it is ensured that the liquid dispensing assembly 5 can be moved arbitrarily within a certain range.

[0064] Refer to Figure 1 , Figure 4 , Figure 5 , Figure 6 Specifically, the liquid dispensing assembly 5 includes a double-layer platform 501. Three liquid injection tanks 502 are fixed at the top end of the upper layer of the double-layer platform 501. Three of the interfaces of the four-way pipe 503 are respectively connected to the output ports of the three liquid injection tanks 502. The last interface of the four-way pipe 503 is connected with a hose 504 through a flange. The hose 504 passes through the double-layer platform 501 and is connected with an injection head 505 through a flange.

[0065] The liquid injection tank 502 contains liquid inside, and there is a piston structure for propulsion at its top, which is convenient for propulsion. The liquid in one of the liquid injection tanks 502 is pushed out. The liquid passes through the four-way pipe 503 and the hose 504 in sequence and is finally discharged at the injection head 505.

[0066] A deflection structure 506 is arranged at the top end of the lower layer of the double-layer platform 501. The deflection structure 506 controls the rotation angle of the injection head 505.

[0067] The injection angle of the injection head 505 is further controlled by the deflection structure 506 to avoid injection dead angles.

[0068] Specifically, the inner parts of the three liquid injection tanks 502 respectively store needle tip liquid on the left, cleaning water in the middle, and base liquid on the right.

[0069] When preparing the micro-needle patch, first inject the needle tip liquid to form the needle tip structure of the micro-needle patch, then wash the needle tip liquid in the whole pipeline with cleaning water, and finally inject the base liquid to form the base part of the micro-needle patch.

[0070] Specifically, the deflection structure 506 includes a hollow skeleton 5061. A ball sleeve 5062 is fixed in the middle of the hollow skeleton 5061. The inside of the ball sleeve 5062 is movably connected with a sphere 5063 through a bearing. The sphere 5063 can rotate in any direction. The sphere 5063 is fixed to the outside of the injection head 505, and the central axis of the sphere 5063 coincides with the central axis of the injection head 505.

[0071] By rotating the sphere 5063, the angle of the injection head 505 can be changed.

[0072] Specifically, two arc-shaped parallel clamping bars 5064 are movably connected to the inside of the hollow skeleton 5061 through bearings. The two arc-shaped parallel clamping bars 5064 are arranged perpendicular to each other. The injection head 505 is located at the clamping position formed by the two arc-shaped parallel clamping bars 5064.

[0073] Two small motors 5065 are fixed on the hollow frame 5061, and the output shafts of the small motors 5065 are transmission-connected with the corresponding arc-shaped parallel clamping strips 5064 through a coupling.

[0074] Through the cooperation of two small motors 5065, the two arc-shaped parallel clamping strips 5064 are controlled to rotate, thereby allowing the injection head 505 to freely rotate within a certain range.

[0075] Embodiment 3:

[0076] Based on the above-mentioned Embodiment 1 and Embodiment 2, further description is given.

[0077] See also Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 The microneedle eye patch is prepared using the above-mentioned configuration equipment, freeze dryer, and vacuum dryer. The specific steps are as follows:

[0078] Step 1: Prepare the mold and install it: prepare a microneedle eye patch mold 3 and place it on the mounting base 2, and the mounting base 2 is installed in the working box 1;

[0079] Specifically:

[0080] Insert the plug 201 through the socket, place the microneedle eye patch mold 3 on the mounting base 2, slide it into the T-slot 101 through the T-shaped structure, and fix it by magnetic attraction to complete the stable installation between the mounting base 2 and the work box 1.

[0081] Step 2: Prepare the needle tip liquid and inject it: the needle tip liquid contains ingredients such as hyaluronic acid mixture, hydroxypropyl methylcellulose HPMC, polyvinyl alcohol PVA and phospholipids. After the above ingredients are dispersed in water, the needle tip liquid is injected into the microneedle eye patch mold 3 through the liquid preparation component 5;

[0082] Specifically:

[0083] The liquid dispensing component 5 is controlled to move arbitrarily within a certain range by the horizontal linear module 401, the lifting device 402, and the vertical linear module 403 in the mobile control component 4. Then, the two arc-shaped parallel clamps 5064 are controlled to rotate by the cooperation of the two small motors 5065. In cooperation with the rotation of the ball 5063, the angle of the injection head 505 can be changed, so that the injection head 505 can rotate freely within a certain range.

[0084] During injection, the piston structure inside the injection tank 502 pushes out the needle tip liquid in the needle tip liquid injection tank 502 , and the needle tip liquid passes through the four-way pipe 503 and the hose 504 in sequence, and is finally discharged from the injection head 505 .

[0085] Step 3. Freeze-drying and thawing of the needle tip liquid: After the needle tip liquid is spread flat in the micro-needle eye patch mold 3, the mounting base 2 and the micro-needle eye patch mold 3 are sent into a freeze-dryer to solidify it, and then the temperature is raised for thawing. The processes of solidification and temperature-raising thawing are repeated multiple times to make the needle tip liquid completely fill the inverted conical cavity 301 of the mold.

[0086] Step 4. Preparation of the base liquid: In the state where the needle tip liquid has not completely solidified, the base liquid is slowly poured along the edge into the micro-needle eye patch mold 3 through the liquid preparation assembly 5. Before injecting the base liquid, the needle tip liquid in the injection pipeline is cleaned with clean water. The base liquid contains components similar to those of the needle tip liquid, and the ratio is adjusted according to requirements to form a stable base part.

[0087] Step 5. Drying and shaping of the micro-needle eye patch: After drying under reduced pressure and vacuum, a large patch is taken out from the micro-needle eye patch mold 3 and cut into shape by wire cutting. Then, glue is applied to the edge of the patch for packaging and radiation sterilization, and the final micro-needle eye patch product is obtained after processing.

[0088] Specifically, after the micro-needle eye patch is formed, the needle tip part of the micro-needle eye patch contains a hyaluronic acid mixture, hydroxypropyl methylcellulose HPMC, polyvinyl alcohol PVA, and phospholipid components.

[0089] The base part of the micro-needle eye patch is composed of at least one of polyvinyl alcohol and its derivatives, polyvinylpyrrolidone and its derivatives, hyaluronic acid or its salts, lactose, sorbitol, dextran, trehalose, and sucrose.

[0090] In the generated micro-needle eye patch, it has multiple characteristics:

[0091] ① Capsule encapsulation: Through a specific preparation process, the drug efficacy components are encapsulated in the needle tip part of the micro-needles to form a stable capsule structure.

[0092] ② Acupuncture slow release: After the micro-needles penetrate the skin, the drug efficacy components can be slowly released into the subcutaneous tissue to achieve the effect of acupuncture slow release.

[0093] ③ Biodegradability: All components of the micro-needle eye patch are biodegradable. Therefore, after use, they can be absorbed by the skin or excreted from the body, without causing pollution to the environment.

[0094] The above is only a preferred specific embodiment of the present invention; however, the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention, according to the technical solution of the present invention and its improved concept, makes equivalent substitutions or changes, and should be covered by the protection scope of the present invention.

Claims

1. A preparation method of a micro acupuncture point patch with stable extraction, which combines capsule encapsulation and acupuncture slow release, including configuring equipment, characterized in that: The configuration device includes an operation box (1). An installation seat (2) is arranged on the inner bottom of the operation box (1). A micro-needle eye patch mold (3) is clamped on the installation seat (2). A moving control component (4) is fixedly installed on the inner side surface of the operation box (1), and a liquid dispensing component (5) is installed on the moving control component (4). Using the above configuration device, freeze dryer, and vacuum dryer to prepare micro-needle eye patches, the specific steps are as follows: Step 1: Prepare the mold and install it: Prepare a micro-needle eye patch mold (3) and place it on the installation seat (2). The installation seat (2) is installed inside the operation box (1). Step 2: Prepare the needle tip liquid and inject it: Inject the needle tip liquid into the micro-needle eye patch mold (3) through the liquid dispensing component (5). Step 3: Freeze-dry and thaw the needle tip liquid: After the needle tip liquid is leveled in the micro-needle eye patch mold (3), it is sent into the freeze dryer to solidify, and then heated to thaw. Repeat the processes of solidification and heating to thaw multiple times until the needle tip liquid completely fills the inverted conical cavity of the mold. Step 4: Prepare the base liquid: Slowly pour the base liquid along the edge into the micro-needle eye patch mold (3) through the liquid dispensing component (5). Step 5: Dry and form the micro-needle eye patch: After vacuum drying under reduced pressure, take out the large patch from the micro-needle eye patch mold (3), and obtain the final micro-needle eye patch product after processing.

2. The preparation method of the extract-stable micro-acupuncture eye patch with both capsule wrapping and acupuncture slow release according to claim 1, characterized in that: The micro-needle eye patch mold (3) is a silicone mold, and a number of inverted conical cavities (301) are arranged on its inner bottom.

3. The preparation method of the micro acupuncture point patch with stable extraction, which combines capsule encapsulation and acupuncture slow release, as described in claim 1, is characterized in that: The bottom end of the installation seat (2) is an iron block with a T-shaped structure. A T-shaped groove (101) is opened at the bottom of the operation box (1), and a magnet is arranged inside the T-shaped groove (101).

4. The preparation method of the extraction-stable micro acupuncture point patch with both capsule encapsulation and acupuncture slow release according to claim 1, characterized in that: Four insertion posts (201) are fixed at the top end of the installation seat (2). A metal frame (302) is wrapped outside the micro-needle eye patch mold (3), and insertion holes slidably connected with the insertion posts (201) are opened on the metal frame (302).

5. The preparation method of the micro acupuncture point patch with stable extraction combining capsule wrapping and acupuncture slow release according to claim 1, characterized in that: The moving control component (4) includes a horizontal linear module (401). Both ends of the horizontal linear module (401) are fixed on the inner wall of the operation box (1). A lifting device (402) is fixedly installed on the moving part of the horizontal linear module (401). A vertical linear module (403) is fixedly installed on the output part of the lifting device (402). The liquid dispensing component (5) is installed at the position of the moving part of the vertical linear module (403).

6. The preparation method of the extraction-stable micro-acupuncture eye patch with both capsule wrapping and acupuncture slow release according to claim 1, characterized in that: The liquid dispensing component (5) includes a double-layer platform (501). Three liquid injection tanks (502) are fixed at the top end of the upper layer of the double-layer platform (501). Three of the interfaces of a four-way pipe (503) are respectively connected to the output ports of the three liquid injection tanks (502). The last interface of the four-way pipe (503) is connected with a hose (504) through a flange. The hose (504) passes through the double-layer platform (501) and is connected with an injection head (505) through a flange. A deflection structure (506) is arranged at the top end of the lower layer of the double-layer platform (501), and the deflection structure (506) controls the rotation angle of the injection head (505).

7. The preparation method of the extraction-stable micro-acupuncture eye patch with both capsule wrapping and acupuncture slow release according to claim 6, characterized in that: The inner parts of the three liquid injection tanks (502) store needle tip liquid, cleaning water, and base liquid respectively.

8. The preparation method of the stable micro-acupuncture eye patch with both capsule encapsulation and acupuncture slow release according to claim 6, characterized in that: The biasing structure (506) includes a hollowed-out framework (5061). A ball socket (5062) is fixed to the middle of the hollowed-out framework (5061). A sphere (5063) is movably connected to the inner side of the ball socket (5062) through a bearing. The sphere (5063) is fixed to the outside of the injection head (505), and the central axis of the sphere (5063) coincides with the central axis of the injection head (505).

9. The preparation method of the extraction-stable micro-acupuncture eye patch with both capsule wrapping and acupuncture slow release according to claim 8, characterized in that: Two arc-shaped parallel clamping strips (5064) are movably connected to the inner side of the hollowed-out framework (5061) through bearings. The two arc-shaped parallel clamping strips (5064) are perpendicularly arranged, and the injection head (505) is located at the clamping position formed by the two arc-shaped parallel clamping strips (5064); Two small motors (5065) are fixed to the hollowed-out framework (5061). The output shafts of the small motors (5065) are in transmission connection with the corresponding arc-shaped parallel clamping strips (5064) through couplings.

10. The preparation method of the extraction-stable micro-acupuncture eye patch with both capsule encapsulation and acupuncture slow release according to claim 1, characterized in that: After the micro-needle patch, the tip part of the micro-needle patch contains components of hyaluronic acid mixture, hydroxypropyl methylcellulose, polyvinyl alcohol, and phospholipids; The base part of the micro-needle patch is composed of at least one of polyvinyl alcohol and its derivatives, polyvinylpyrrolidone and its derivatives, hyaluronic acid or its salts, lactose, sorbitol, dextran, trehalose, and sucrose.

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