Automated analyzer

Abstract

An automatic analysis device is provided with a dispensing nozzle (30) having an opening (OP1), a needle (40) having an opening (OP2) and an opening (OP3), and a control unit for controlling the suction operation and discharge operation of the dispensing nozzle (30). When the liquid (LQ2) is discharged from the inside of the dispensing nozzle (30) to the inside of the needle (40) via the opening (OP1) and the liquid (LQ2) and the residual liquid (LQ1a) are discharged from the inside of the needle (40) to the outside of the needle (40) via the opening (OP3), the liquid (LQ2) is discharged so as to contact the inner wall of the needle (40) while reaching the opening (OP3) from the opening (OP1).

Description

Technical Field

[0001] The present invention relates to an automatic analysis device. Background Art

[0002] An automatic analysis device is known, which includes a dispensing nozzle for sucking and discharging liquids such as specimens or reagents like blood. In the automatic analysis device, after discharging the sucked liquid into a specified container, an operation of sucking other liquid is performed. At this time, in order to ensure the analysis accuracy, it is very important to prevent the liquid sucked previously from mixing into the dispensing nozzle. Therefore, a method of attaching a disposable needle (hereinafter simply referred to as a needle) to the tip of the dispensing nozzle is generally adopted. Here, a liquid suction tube is disclosed, which can prevent liquid from adhering to the suction hole even when the liquid remaining in the needle scatters when the needle is detached (see Patent Document 1). Prior Art Documents Patent Documents

[0003] Patent Document 1: Japanese Patent Application Laid-Open No. 2008-249659 Summary of the Invention Technical Problem to be Solved by the Invention

[0004] According to Patent Document 1, even when the remaining liquid scatters when the needle is detached, the adhesion of the remaining liquid to the dispensing nozzle can be suppressed. However, no countermeasure against the scattering that occurs when the liquid discharged from the dispensing nozzle comes into contact with the remaining liquid in the needle is mentioned.

[0005] The main object of the present application is to provide an automatic analysis device that can discharge other liquid from the dispensing nozzle into the needle so that when the needle is detached, the opening of the dispensing nozzle does not directly contact the liquid remaining in the needle. Thereby, a reduction in the analysis accuracy of using the automatic analysis device is suppressed.

[0006] Other problems and new features are clarified according to the description of this specification and the drawings. Technical Means for Solving the Technical Problem

[0007] An automatic analysis device according to an embodiment includes: a nozzle having a first opening for sucking and discharging a liquid; a needle having a second opening for mounting on the nozzle to surround the first opening and a third opening for sucking and discharging a liquid; and a control unit for controlling the sucking operation and discharging operation of the nozzle. In a state where the needle is mounted on the nozzle, a first liquid is sucked from the outside of the needle into the inside of the needle through the third opening, the first liquid is discharged from the inside of the needle to the outside of the needle through the third opening, and then a second liquid is discharged from the inside of the nozzle to the inside of the needle through the first opening. When the second liquid and the first liquid remaining inside the needle are discharged from the inside of the needle to the outside of the needle through the third opening, the second liquid is discharged in contact with the inner wall of the needle during the period from the first opening to the third opening. Advantages of the Invention

[0008] According to one embodiment, a reduction in the analysis accuracy of an automatic analysis device can be suppressed. BRIEF DESCRIPTION OF THE DRAWINGS

[0009] Figure 1 is a top view showing an outline of the automatic analysis device. Figure 2 is a schematic view showing a specimen dispensing mechanism. Figure 3 is a schematic view showing each operation performed using the specimen dispensing mechanism. Figure 4 is a schematic view showing a needle detachment portion. Figure 5 is a flowchart showing each step of a needle detachment operation performed in the needle detachment portion. Figure 6 is a schematic view showing each step of the needle detachment operation performed in the needle detachment portion. Figure 7 is a perspective view showing the needle. Figure 8 is a top view showing the needle. Figure 9 is a perspective view showing a state where a liquid is discharged from inside the dispensing nozzle to inside the needle. Figure 10 is a perspective view showing the dispensing nozzle. Figure 11 is a cross-sectional view showing the dispensing nozzle. Figure 12 is a schematic view showing a state where a liquid is discharged from the dispensing nozzle into the needle. DETAILED DESCRIPTION OF THE INVENTION

[0010] Hereinafter, embodiments will be described in detail with reference to the drawings. In addition, in all the drawings used to describe the embodiments, components having the same function are assigned the same reference numerals, and redundant descriptions are omitted. In addition, in the following embodiments, unless otherwise particularly required, descriptions of the same or similar parts are not repeated in principle.

[0011] In addition, the X direction, Y direction, and Z direction described in the present application are perpendicular to each other and orthogonal. The Z direction includes the Z1 direction and the Z2 direction which is the opposite direction of the Z1 direction. In the present application, the Z1 direction is set as the downward direction, and the Z2 direction is set as the upward direction. In addition, expressions such as "top view" or "when viewed from above" used in the present application mean that the plane formed by the X direction and the Y direction is the "plane", and this "plane" is observed in the Z1 direction.

[0012] (Embodiment 1) <Structure of the Automatic Analysis Device> Hereinafter will be used Figure 1 to describe the automatic analysis device 1 of Embodiment 1.

[0013] As Figure 1 shown, the automatic analysis device 1 includes: a rack conveyor line 4, a reagent cold storage unit 5, a reaction plate (culture plate) 8, a needle storage part 11, a consumable conveyor unit 12, a detection unit 13, a reagent dispensing mechanism 14, a specimen dispensing mechanism 20, a dispensing nozzle 30, a needle 40, a needle detachment part 50, and a control part 60, etc.

[0014] The rack conveyor line 4 is used to convey the specimen rack 2. The specimen rack 2 houses a plurality of specimen containers 3. Biological specimens such as blood or urine are respectively accommodated in the plurality of specimen containers 3. In a state where the plurality of specimen containers 3 are accommodated in the specimen rack 2, the specimen rack 2 is conveyed on the rack conveyor line 4.

[0015] The reagent cold storage unit 5 is used to store or keep cold a plurality of reagent containers 7. Various reagents for analyzing specimens are accommodated in the plurality of reagent containers 7. In addition, at least a part of the upper surface of the reagent cold storage unit 5 is covered by a reagent plate cover 6.

[0016] The reaction plate 8 serves as a place for the reaction between the specimen and the reagent. The reaction plate 8 has a reaction container setting part 9 for arranging a plurality of reaction containers 10 and a temperature adjusting mechanism (not shown) for adjusting the temperature of the reaction containers 10 to a desired temperature.

[0017] A plurality of needles 40 are provided in the needle temporary storage unit 11. The needles 40 are mounted on the dispensing nozzle 30 in the needle temporary storage unit 11. In addition, the needles 40 are disposable needles for single use. Further, the used needles 40 are detached from the dispensing nozzle 30 in the needle detachment unit 50.

[0018] The consumable transfer unit 12 transfers consumables such as the standing needles 40 or the reaction vessels 10 to a specified position.

[0019] The specimen dispensing mechanism 20 includes a dispensing nozzle 30 and a rotation drive mechanism and an up-down drive mechanism (not shown) that are drive units for the dispensing nozzle 30. The specimen holder 2, the reaction vessel setting unit 9, the needle temporary storage unit 11, and the needle detachment unit 50 are arranged on the drive line of the dispensing nozzle 30. Figure 1 In, such a drive line is indicated by a dashed line. In addition, the drive lines of other dispensing mechanisms are also indicated by dashed lines in the same way.

[0020] The reagent dispensing mechanism 14 further includes a reagent dispensing nozzle and a reagent rotation drive mechanism and an up-down drive mechanism (not shown) that are drive units for the reagent dispensing nozzle. Through these drive mechanisms, the reagent is dispensed from the reagent container 7 into the reaction vessel 10 accommodated in the reaction disk 8.

[0021] In the detection unit 13, a specimen that has undergone a specified process such as reagent mixing is inspected. The detection unit 13 includes a photomultiplier tube, a light source lamp, a spectroscope, a photodiode, etc., and also has a function of adjusting their temperatures. For example, the detection unit 13 can measure the amount of antigen contained in the specimen by detecting the light generated during the reaction between the labeled antibody that binds to the antigen of the specimen and the luminescent substrate using the photomultiplier tube.

[0022] Figure 2 The schematic structure of the specimen dispensing mechanism 20 in Embodiment 1 is shown.

[0023] The liquid supply tank 21 is filled with the liquid LQ2. The liquid LQ2 is, for example, water of polar molecules or an aqueous solution using the above-mentioned water as a solvent. A liquid supply pump 22 and a solenoid valve 23 are provided in the flow path 24 connecting the liquid supply tank 21 and the syringe 26. The liquid LQ2 in the liquid supply tank 21 is transported to the syringe 26 by the liquid supply pump 22. The opening and closing operation of the flow path 24 is controlled by the solenoid valve 23.

[0024] The syringe 26 is composed of a cylinder 26a and a plunger 26b. The syringe drive unit 27 is electrically connected to the plunger 26b. By driving the plunger 26b up and down relative to the cylinder 26a by the syringe drive unit 27, the liquid LQ2 filled inside the syringe 26 is operated. Thereby, the specimen dispensing mechanism 20 performs a liquid suction operation and a discharge operation.

[0025] The dispensing nozzle 30 is connected to the syringe 26 via the flow path 25. The inside of the flow path 25 is filled with the liquid LQ2. The dispensing nozzle 30 is electrically connected to a dispensing nozzle drive unit 28 such as a motor. By the dispensing nozzle drive unit 28, the dispensing nozzle 30 can be moved in the horizontal direction and the vertical direction, and the dispensing nozzle 30 can be moved to a specified position.

[0026] The control unit 60 is an arithmetic device including a semiconductor device such as a CPU. The control unit 60 is electrically connected to the solenoid valve 23, the syringe drive unit 27, and the dispensing nozzle drive unit 28, and controls their operations. That is, the suction operation and the discharge operation of the dispensing nozzle 30 are controlled by the control unit 60. In addition, the control unit 60 also controls the respective operations performed by the respective mechanisms provided in the automatic analyzer 1, such as the bracket transfer line 4, the reagent cold storage unit 5, the reaction disk 8, the consumable transfer unit 12, the detection unit 13, the reagent dispensing mechanism 14, and the specimen dispensing mechanism 20.

[0027] Figure 2 The state where the needle 40 is attached to the dispensing nozzle 30 is shown. The dispensing nozzle 30 has an opening OP1 for sucking and discharging the liquid. The needle 40 has an opening OP2 and an opening OP3. The opening OP2 is provided for attachment to the dispensing nozzle 30 so as to surround the opening OP1. The opening OP3 is provided for sucking and discharging the liquid.

[0028] In the state where the needle 40 is attached to the dispensing nozzle 30, the opening direction of each of the opening OP1 and the opening OP3 is the same direction, and is the Z1 direction. The opening direction of the opening OP2 is the direction opposite to the opening direction of each of the opening OP1 and the opening OP3, and is the Z2 direction.

[0029] In the needle temporary storage unit 11, after the needle 40 is attached to the dispensing nozzle 30, in the specimen dispensing mechanism 20, the dispensing nozzle 30 sucks the liquid LQ1 from the specimen container 3 on the specimen rack 2. In addition, the liquid LQ1 is a specimen liquid, for example, a biological sample such as blood or urine. Next, the dispensing nozzle 30 dispenses the liquid LQ1 into the reaction container 10 accommodated in the reaction disk 8. Thereafter, in the needle detachment unit 50, the needle 40 is detached from the dispensing nozzle 30.

[0030] Figure 3 The respective basic operations performed using the specimen dispensing mechanism 20 are shown.

[0031] When sucking the liquid LQ1 from the specimen container 3, before the suction operation, air (segmented air) is sucked into the dispensing nozzle 30 to prevent the liquid LQ2 and the liquid LQ1 filled inside the dispensing nozzle 30 from being mixed. Next, in the needle temporary storage unit 11, the needle 40 is attached to the dispensing nozzle 30.

[0032] Next, the dispensing nozzle driving unit 28 lowers the dispensing nozzle 30 until the opening OP3 of the needle 40 reaches into the liquid LQ1. The suction operation of the dispensing nozzle 30 is performed by the syringe driving unit 27. Thereby, the liquid LQ1 is sucked into the inside of the needle 40 from the outside of the needle 40 (specimen container 3) via the opening OP3.

[0033] After the suction operation is completed, the dispensing nozzle 30 is moved to a specified specimen discharge position. Next, the syringe driving unit 27 performs the discharge operation of the dispensing nozzle 30. Thereby, the liquid LQ1 is discharged from the inside of the needle 40 to the outside of the needle 40 (reaction vessel 10) via the opening OP3.

[0034] At this time, near the opening OP3, a part of the liquid LQ1 may remain as the residual liquid LQ1a inside the needle 40.

[0035] After the liquid LQ1 is discharged from the inside of the needle 40, the dispensing nozzle 30 is moved to the needle detachment part 50, and the needle 40 is detached from the dispensing nozzle 30. At this time, the liquid LQ2 in the liquid supply tank 21 is supplied to the inside of the dispensing nozzle 30 by the liquid supply pump 22 or the syringe 26. The liquid LQ2 is discharged from the inside of the dispensing nozzle 30 to the inside of the needle 40 via the opening OP1, and the liquid LQ2 and the residual liquid LQ1a are discharged from the inside of the needle 40 to the outside of the needle 40 via the opening OP3.

[0036] When the needle 40 is detached, by discharging the liquid LQ2 into the inside of the needle 40, the residual liquid LQ1a is removed from the inside of the needle 40, and the decompression inside the needle 40 is alleviated.

[0037] During the period when the liquid LQ2 is discharged from the inside of the dispensing nozzle 30 to the inside of the needle 40, the dispensing nozzle 30 is raised so that the upper surface (opening OP2) of the needle 40 collides with the detachment plate 51 of the needle detachment part 50. Thereby, the needle 40 is detached from the dispensing nozzle 30.

[0038] When the liquid LQ2 is discharged into the inside of the needle 40, the liquid LQ2 may collide with the residual liquid LQ1a, and the residual liquid LQ1a scatters, and the residual liquid LQ1a may come into direct contact with the dispensing nozzle 30. Then, when the next suction operation is performed, the residual liquid LQ1a falls from the dispensing nozzle 30 into the inside of the needle 40, so that the residual liquid LQ1a may be mixed into the next specimen liquid, and there is a problem that the accuracy of the analysis using the automatic analyzer 1 is reduced.

[0039] In Embodiment 1, to solve such a problem, the structure of the needle detachment part 50 was improved.

[0040] <Features of the needle detachment portion 50> In the automatic analysis device 1 of Embodiment 1, the liquid LQ2 discharged from the dispensing nozzle 30 is attracted to the inner wall side of the needle 40 by electrostatic force. By preventing the liquid LQ2 from directly colliding with the residual liquid LQ1a, the scattering of the residual liquid LQ1a can be suppressed. Therefore, since the direct contact between the residual liquid LQ1a and the dispensing nozzle 30 can be suppressed, the reduction in the analysis accuracy when using the automatic analysis device 1 can be suppressed.

[0041] Figure 4 The schematic structure of the needle detachment portion 50 is shown. The needle detachment portion 50 includes a detachment plate 51 and a side wall 52. The detachment plate 51 is provided on the upper part of the side wall 52. In addition, although not shown in the figure, a first hole having a diameter larger than the opening OP2 of the needle 40 and a second hole having a diameter smaller than the opening OP2 are provided in the detachment plate 51. The first hole and the second hole communicate with each other. When the needle 40 is moved into the needle detachment portion 50, the first hole is used, and when the needle 40 is detached from the dispensing nozzle 30, the second hole is used.

[0042] A charged body 54 that can be positively or negatively charged is provided on the side wall 52. A charging device 53 for discharging is provided at a portion of the side wall 52 that is opposite to the portion where the charged body 54 is provided. The control unit 60 is electrically connected to the charging device 53 and controls the voltage supplied to the charging device 53 so that the charged body 54 is positively or negatively charged.

[0043] The needle 40 is positioned adjacent to the charged body 54. When the charged body 54 is positively or negatively charged, polarization occurs inside the needle 40. As a result, the surface of the inner wall of the needle 40 is charged with the same polarity as the charged body 54. The liquid LQ2 contains polar molecule water and has the property of being attracted by positive or negative charges. Therefore, by polarizing the resin inside the needle 40 and locally charging the surface of the inner wall of the needle 40 with either positive or negative charge, the discharge direction of the liquid LQ2 can be attracted to the charged portion of the inner wall of the needle 40.

[0044] Figure 5 It is a flowchart showing steps S1 to S6 of the needle detachment operation performed in the needle detachment portion 50. Figure 6 Schematically shows Figure 5 the situation of steps S1 to S6 in

[0045] First, in step S1, the dispensing nozzle 30 equipped with the needle 40 is moved onto the detachment plate 51 of the needle detachment portion 50.

[0046] Next, in step S2, a voltage is applied to the charging device 53 to cause the charging device 53 to discharge, so that the charged body 54 is positively or negatively charged.

[0047] Next, in step S3, the dispensing nozzle 30 is lowered, and the needle 40 is moved below the separation plate 51. As a result, the needle 40 is positioned adjacent to the charged body 54 within the space surrounded by the separation plate 51 and the side wall 52. Polarization occurs locally inside the needle 40 near the charged body 54, and the surface of the inner wall of the needle 40 is charged with the same polarity as the charged body 54.

[0048] Next, in step S4, the liquid LQ2 is discharged from the inside of the dispensing nozzle 30 to the inside of the needle 40 via the opening OP1, and the liquid LQ2 and the residual liquid LQ1a are discharged from the inside of the needle 40 to the outside of the needle 40 via the opening OP3. The liquid LQ2 discharged into the inside of the needle 40 is attracted by the electrostatic force of the charges on the inner wall surface of the needle 40 and is discharged along the inner wall of the needle 40. That is, during the period when the liquid LQ2 reaches the opening OP3 from the opening OP1, the liquid LQ2 is discharged in contact with the inner wall of the needle 40. Since the liquid LQ2 does not directly collide with the residual liquid LQ1a, scattering of the residual liquid LQ1a can be suppressed.

[0049] Next, in step S5, the dispensing nozzle 30 is raised, and the upper surface (opening OP2) of the needle 40 collides with the separation plate 51, so that the needle 40 is detached from the dispensing nozzle 30. In addition, the dispensing nozzle 30 is raised during the period when the liquid LQ2 is discharged from the inside of the dispensing nozzle 30 to the inside of the needle 40.

[0050] Next, in step S6, after the needle 40 is detached, the discharge of the liquid LQ2 from the dispensing nozzle 30 is stopped. Thus, the detachment operation of the needle 40 is completed.

[0051] (Embodiment 2) The following will use Figures 7 to 9 to describe the automatic analysis device 1 of Embodiment 2. In addition, in the following description, the differences from Embodiment 1 will be mainly described, and the description of repeated points will be omitted.

[0052] In Embodiment 2, similar to Embodiment 1, scattering of the residual liquid LQ1a can be suppressed by preventing the liquid LQ2 from directly colliding with the residual liquid LQ1a. For this reason, in Embodiment 2, the internal structure of the needle 40 is improved.

[0053] As Figure 7 and Figure 8 shown, the needle 40 in Embodiment 2 includes a water blocking body 41 as a structure for obstructing the flow of the liquid LQ2 discharged from the opening OP1 of the dispensing nozzle 30. The water blocking body 41 is provided on a part of the inner wall 40a such that a space is formed between the water blocking body 41 and the inner wall 40a of the needle 40.

[0054] In addition, the liquid blocking body 41 is arranged at a position spaced apart from the end of the dispensing nozzle 30 and both end portions of the needle 40 by a certain distance. In other words, the liquid blocking body 41 is located between the opening OP2 and the opening OP3. When the needle 40 is mounted on the dispensing nozzle 30, the liquid blocking body 41 is located between the opening OP1 and the opening OP3.

[0055] Figure 9 The case where the liquid LQ2 is discharged from the opening OP1 of the dispensing nozzle 30 into the inside of the needle 40 is shown. By the liquid LQ2 discharged from the dispensing nozzle 30 contacting the liquid blocking body 41, the liquid LQ2 is discharged without directly colliding with the residual liquid LQ1a. The liquid LQ2 contacting the liquid blocking body 41 mainly flows along the inner wall 40a of the needle 40 toward the opening OP3 side. That is, during the period from the opening OP1 to the opening OP3, the liquid LQ2 is discharged in a manner of contacting the inner wall of the needle 40. Thereby, the scattering of the residual liquid LQ1a is suppressed.

[0056] In addition, as Figure 8 shown, in order to make the liquid LQ2 reliably contact the liquid blocking body 41, it is desirable that the liquid blocking body 41 be arranged at a position overlapping the opening OP1 in a plan view. In addition, the larger the liquid blocking body 41 is, the easier it is for the liquid LQ2 to reliably contact the liquid blocking body 41. For example, in the direction ( Figure 8 X direction in

[0057] (Embodiment 3) The automatic analysis device 1 of Embodiment 3 will be described below using Figures 10 to 12 . In addition, in the following description, the differences from Embodiment 1 and Embodiment 2 will be mainly described, and the description of the repeated points will be omitted.

[0058] In Embodiment 3, by preventing the liquid LQ2 from directly colliding with the residual liquid LQ1a, the scattering of the residual liquid LQ1a can be suppressed, which is the same as in Embodiment 1 and Embodiment 2. For this purpose, in Embodiment 3, the end of the dispensing nozzle 30 is improved.

[0059] As Figure 10 and Figure 11As shown, the dispensing nozzle 30 of Embodiment 3 includes a front end portion 31 mounted to the front end of the opening OP1. An opening OP4 communicating with the opening OP1 is provided in the front end portion 31. The opening direction of the opening OP4 is different from the opening direction of the opening OP1 and is orthogonal to the opening direction of the opening OP1. By arranging the opening OP4 toward the inner wall 40a of the needle 40, the liquid LQ2 mainly flows along the inner wall 40a of the needle 40 toward the opening OP3 side.

[0060] Figure 12 The case where the liquid LQ2 is discharged from the opening OP4 of the dispensing nozzle 30 into the needle 40 is shown. When the liquid LQ2 is discharged from the opening OP4 of the dispensing nozzle 30 into the needle 40, the liquid LQ2 is discharged via the opening OP1 and the opening OP4. When the liquid LQ2 and the residual liquid LQ1a are discharged from the inside of the needle 40 to the outside of the needle 40 via the opening OP3, the liquid LQ2 is discharged in contact with the inner wall of the needle 40 during the period from the opening OP4 to the opening OP3. Thereby, the scattering of the residual liquid LQ1a is suppressed.

[0061] As described above, the present invention has been specifically described based on the above embodiments, but the present invention is not limited to the above embodiments and can be variously modified without departing from the gist thereof. Reference Numeral Explanation

[0062] 1 Automatic analysis device 2 Specimen holder 3 Specimen container 4 Holder transfer line 5 Reagent cold storage unit 6 Reagent disk cover 7 Reagent container 8 Reaction disk 9 Reaction vessel setting portion 10 Reaction vessel 11 Needle temporary storage portion 12 Consumable transfer unit 13 Detection unit 14 Reagent dispensing mechanism 20 Specimen dispensing mechanism 21 Liquid supply tank 22 Liquid supply pump 23 Electromagnetic valve 24 Flow path 25 Flow path 26 Syringe 26a Cylinder 26b Plunger 27 Syringe drive unit 28 Dispensing nozzle drive unit 30 Dispensing nozzle 31 Front end part 40 Needle 40a Inner wall of the needle 41 Water retaining body 50 Needle detachment part 51 Detachment plate 52 Side wall 53 Charging device 54 Charged body 60 Control part LQ1 Liquid (specimen liquid) LQ1a Residual liquid LQ2 Liquid OP1 Opening part of the dispensing nozzle OP2 Opening part of the needle OP3 Opening part of the needle OP4 Opening part of the front end part.

Claims

1. An automatic analysis device, characterized in that, Comprising: A nozzle having a first opening for sucking and discharging liquid; A needle having a second opening for mounting on the nozzle to surround the first opening and a third opening for sucking and discharging liquid; And A control unit that controls the sucking and discharging operations of the nozzle. When the needle is mounted on the nozzle, a first liquid is sucked from the outside of the needle into the inside of the needle via the third opening, the first liquid is discharged from the inside of the needle to the outside of the needle via the third opening, and then a second liquid is discharged from the inside of the nozzle to the inside of the needle via the first opening. When the second liquid and the first liquid remaining inside the needle are discharged from the inside of the needle to the outside of the needle via the third opening, the second liquid is discharged in contact with the inner wall of the needle during the period from the first opening to the third opening.

2. The automatic analysis device according to claim 1, characterized in that It further includes a needle detachment part for detaching the needle from the nozzle. The needle detachment part includes a side wall and a detachment plate provided at the upper part of the side wall. A charged body capable of being positively or negatively charged is provided on the side wall.

3. The automatic analysis device according to claim 2, characterized in that A charging device for discharging is provided at a portion of the side wall opposite to the portion where the charged body is provided. The control unit is electrically connected to the charging device and controls the voltage supplied to the charging device to make the charged body carry the positive potential or the negative potential.

4. The automatic analysis device according to claim 2, characterized in that When the needle is mounted on the nozzle and the second liquid is discharged from the inside of the nozzle to the inside of the needle via the first opening and the second liquid and the first liquid remaining inside the needle are discharged from the inside of the needle to the outside of the needle via the third opening, the needle is located adjacent to the charged body in the space surrounded by the detachment plate and the side wall.

5. The automatic analysis device according to claim 2, characterized in that When the needle is mounted on the nozzle, the opening directions of each of the first opening and the third opening are the same direction and are opposite to the opening direction of the second opening.

6. The automatic analysis device according to claim 1, characterized in that The needle includes a water blocking body located between the second opening and the third opening. The water blocking body is provided on a part of the inner wall of the needle such that a space is formed between the water blocking body and the inner wall of the needle.

7. The automatic analysis device according to claim 6, characterized in that ​ ​ ​ ​ ​ In a state where the needle is mounted on the nozzle, the opening directions of each of the first opening and the third opening are the same direction, and are in a direction opposite to the opening direction of the second opening. When the needle is mounted on the nozzle, the water blocking body is located between the first opening and the third opening.

8. The automatic analysis device according to claim 7, characterized in that In a direction orthogonal to the opening direction of the first opening, the width of the water blocking body is greater than the opening width of the first opening.

9. The automatic analysis device according to claim 1, characterized in that The nozzle includes a front end portion mounted at the front end of the first opening. A fourth opening communicating with the first opening is provided on the front end portion. The opening direction of the fourth opening is different from the opening direction of the first opening.

10. The automatic analysis device according to claim 9, characterized in that The opening direction of the fourth opening is orthogonal to the opening direction of the first opening.

11. The automatic analysis device according to claim 9, characterized in that When the second liquid is discharged from the inside of the nozzle to the inside of the needle, the second liquid is discharged via the first opening and the fourth opening. When the second liquid and the first liquid remaining inside the needle are discharged from the inside of the needle to the outside of the needle via the third opening, the second liquid is discharged in a manner of contacting the inner wall of the needle during the period from the fourth opening to the third opening.

12. The automatic analysis device according to claim 9, characterized in that In a state where the needle is mounted on the nozzle, the opening directions of each of the first opening and the third opening are the same direction, and are in a direction opposite to the opening direction of the second opening. The opening direction of the fourth opening is different from the opening directions of each of the first opening, the second opening, and the third opening.

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