Traditional Chinese medicine for regulating menstruation and promoting pregnancy

Abstract

The invention discloses a menstruation regulating and pregnancy promoting traditional Chinese medicine which follows a weekly regulation method of traditional Chinese medicine, and adopts a first traditional Chinese medicine composition, a second traditional Chinese medicine composition and a third traditional Chinese medicine composition for reasonable treatment according to the physiological characteristics of the menstrual cycle and by combining the characteristics of growth and development, fertilization, implantation and the like of follicles at different stages of the menstrual cycle. In the menstrual period (menstrual period), blood circulation is promoted to remove blood stasis, yang is warmed to expel turbidity to convert yang into yin; in the late stage (follicular stage), yin and blood are nourished, eggs are raised, and membranes are increased; the traditional Chinese medicine composition can tonify yin and yang in the intermenstrual period (ovulation period), promote blood circulation to remove meridian obstruction so as to convert yin to yang, finally achieve menstruation regulation and pregnancy promotion, and is short in treatment cycle and free of side effects for women, especially 30 + old women with difficulty in pregnancy or infertility or bad pregnant women.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine for regulating menstruation and promoting pregnancy. Background Art

[0002] In today's society, due to the influence of environmental pollution, work pressure, lifestyle, etc., it is difficult for women of childbearing age, especially older women over 30, to get pregnant, and the proportion of infertility is even increasing. For traditional treatment of pregnancy difficulties or infertility, surgical treatment or western medicine treatment is mostly adopted. Surgical treatment has high costs and is prone to sequelae such as postoperative pain and menstrual disorders. Almost all western medicine treatment drugs contain hormones, which not only have a long treatment cycle but also have large side effects, such as weight gain and getting fat, and are not acceptable to some people. Summary of the Invention

[0003] Therefore, based on the above background, the present invention provides a traditional Chinese medicine for regulating menstruation and promoting pregnancy. According to the physiological characteristics of the menstrual cycle, different traditional Chinese medicine compositions are used for treatment at different stages of the menstrual cycle to achieve the regulation of menstruation and promotion of pregnancy, with a short conditioning time and small side effects.

[0004] The technical solution of the present invention is as follows:

[0005] A traditional Chinese medicine for regulating menstruation and promoting pregnancy, which comprises a first traditional Chinese medicine composition, a second traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0006] The first traditional Chinese medicine composition is composed of the following raw materials by weight:

[0007] Angelica sinensis 5 - 15 parts, Ligusticum wallichii 3 - 10 parts, Prunus persica 6 - 20 parts, Leonurus japonicus 10 - 20 parts, Paeonia lactiflora 10 - 20 parts, Salvia miltiorrhiza 10 - 20 parts, Artemisia argyi 8 - 15 parts (fried), Cyperus rotundus 5 - 15 parts, Lindera aggregata 5 - 15 parts, Aucklandia lappa 5 - 15 parts, Cinnamomum cassia 5 - 15 parts, Glycyrrhiza uralensis 3 - 10 parts;

[0008] The second traditional Chinese medicine composition is composed of the following raw materials by weight:

[0009] Angelica sinensis 8 - 18 parts, Paeonia lactiflora 8 - 18 parts, Rehmannia glutinosa 12 - 25 parts, Cuscuta chinensis 20 - 40 parts, Astragalus complanatus 10 - 20 parts, Plantago asiatica 10 - 20 parts, Lycium barbarum 5 - 15 parts, Schisandra chinensis 5 - 15 parts (processed), Tribulus terrestris 10 - 20 parts (processed), Polygonatum sibiricum 10 - 20 parts;

[0010] The third traditional Chinese medicine composition is composed of the following raw materials by weight:

[0011] 10 - 20 parts of Angelica sinensis, 5 - 15 parts of Curcuma longa, 20 - 40 parts of Salvia miltiorrhiza, 10 - 20 parts of Paeonia lactiflora, 10 - 20 parts of Eupatorium lindleyanum, 10 - 20 parts of Cistanche deserticola, 10 - 20 parts of Eucommia ulmoides, 10 - 20 parts of Dioscorea opposita, 8 - 20 parts of Curcuma aromatica, 3 - 15 parts of Cinnamomum cassia, 10 - 20 parts of Spatholobus suberectus, 10 - 20 parts of Sargentodoxa cuneata, 10 - 20 parts of Cyathula officinalis.

[0012] Furthermore, the first traditional Chinese medicine composition is composed of raw materials with the following weights:

[0013] 10 parts of Angelica sinensis, 6 parts of Ligusticum chuanxiong, 9 parts of Prunus persica, 15 parts of Leonurus japonicus, 15 parts of Paeonia lactiflora, 15 parts of Salvia miltiorrhiza, 10 parts of stir - fried Artemisia argyi, 10 parts of Cyperus rotundus, 10 parts of Lindera aggregata, 10 parts of Aucklandia lappa, 10 parts of Cinnamomum cassia, 6 parts of Glycyrrhiza uralensis.

[0014] Furthermore, the first traditional Chinese medicine composition is composed of raw materials with the following weights:

[0015] 6 parts of Angelica sinensis, 3 parts of Ligusticum chuanxiong, 6 parts of Prunus persica, 20 parts of Leonurus japonicus, 20 parts of Paeonia lactiflora, 20 parts of Salvia miltiorrhiza, 6 parts of Rhizoma Cyperi prepared with vinegar, 6 parts of Radix Linderae aggregata prepared with vinegar, 6 parts of Aucklandia lappa, 6 parts of Cinnamomum cassia, 3 parts of Glycyrrhiza uralensis.

[0016] Furthermore, the second traditional Chinese medicine composition is composed of raw materials with the following weights:

[0017] 12 parts of Angelica sinensis, 12 parts of Paeonia lactiflora, 20 parts of Rehmannia glutinosa, 30 parts of Cuscuta chinensis, 15 parts of Astragalus complanatus, 15 parts of Plantago asiatica, 10 parts of Lycium barbarum, 10 parts of Schisandra chinensis, 15 parts of Tribulus terrestris, 15 parts of Polygonatum sibiricum.

[0018] Furthermore, the second traditional Chinese medicine composition is composed of raw materials with the following weights:

[0019] 15 parts of Angelica sinensis, 3 parts of Ligusticum chuanxiong, 18 parts of Paeonia lactiflora, 20 parts of Rehmannia glutinosa, 20 parts of Cuscuta chinensis, 10 parts of Astragalus complanatus, 10 parts of Plantago asiatica, 10 parts of Lycium barbarum, 10 parts of Schisandra chinensis prepared with salt, 10 parts of Tribulus terrestris, 10 parts of Polygonatum sibiricum.

[0020] Furthermore, the third traditional Chinese medicine composition is composed of raw materials with the following weights:

[0021] 15 parts of Angelica sinensis, 10 parts of Curcuma longa, 30 parts of Salvia miltiorrhiza, 15 parts of Paeonia lactiflora, 15 parts of Eupatorium lindleyanum, 15 parts of Cistanche deserticola, 15 parts of Eucommia ulmoides, 15 parts of Dioscorea opposita, 12 parts of Curcuma aromatica, 6 parts of Cinnamomum cassia, 15 parts of Spatholobus suberectus, 15 parts of Sargentodoxa cuneata, 15 parts of Cyathula officinalis.

[0022] Furthermore, the third traditional Chinese medicine composition is composed of raw materials with the following weights:

[0023] 10 parts of Angelica sinensis, 5 parts of Curcuma longa, 15 parts of Salvia miltiorrhiza, 10 parts of Paeonia lactiflora, 10 parts of Eupatorium lindleyanum, 10 parts of Cistanche deserticola, 10 parts of Eucommia ulmoides, 10 parts of Dioscorea opposita, 10 parts of Curcuma aromatica, 3 parts of Cinnamomum cassia, 20 parts of Caulis Spatholobi, 20 parts of Caulis Sargentodoxae, 10 parts of Cyathula officinalis.

[0024] Further, the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition are respectively added with pharmaceutically acceptable adjuvants to prepare oral preparations.

[0025] Further, the oral preparations are capsules, tablets, oral solutions, or pills.

[0026] Further, when the oral preparation is a capsule, its preparation method includes the following steps:

[0027] S1: Process the raw drugs.

[0028] S2: After separately pulverizing the raw drugs, sieve them through 100 meshes.

[0029] S3: Take the raw drugs in proportion, mix them, and respectively prepare the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition.

[0030] S4: Fill the separately prepared first traditional Chinese medicine composition, second traditional Chinese medicine composition, and third traditional Chinese medicine composition into capsules respectively.

[0031] Further, the specific operations for processing the drugs in step S1 are as follows:

[0032] The Angelica sinensis in the first traditional Chinese medicine composition and the second traditional Chinese medicine composition is stir-fried with wine.

[0033] The Ligusticum chuanxiong in the first traditional Chinese medicine composition is stir-fried with wine, and the Lindera aggregata is stir-fried with vinegar.

[0034] The Prunus persica in the first traditional Chinese medicine composition is stir-fried yellow with bran by heating.

[0035] The Cyperus rotundus in the first traditional Chinese medicine composition is stir-fried yellow with vinegar.

[0036] The Rehmannia glutinosa in the second traditional Chinese medicine composition is steamed nine times in a pot by heating.

[0037] The Schisandra chinensis in the second traditional Chinese medicine composition is stir-fried with salt, and the Trigonella foenum-graecum is stir-fried with salt.

[0038] Based on the same inventive concept, the present invention applies the above traditional Chinese medicine drugs to the preparation of drugs for treating / assisting in treating infertility or adverse pregnancy outcomes.

[0039] According to the menstrual cycle regulation method of traditional Chinese gynecology, the menstrual cycle is divided into the menstrual period, the late menstrual period (follicular phase), the intermenstrual period (ovulatory phase), and the premenstrual period. Then, based on the physiological characteristics during the menstrual cycle, the present invention rationally administers medicine in three stages of the menstrual cycle. Among them, the first traditional Chinese medicine composition is used for treatment during the menstrual period, the second traditional Chinese medicine composition is used for treatment during the late menstrual period, and the third traditional Chinese medicine composition is used for treatment during the intermenstrual period.

[0040] The specific pharmacology of the drugs of the present invention is as follows:

[0041] Traditional Chinese medicine believes that during the menstrual period, the medicine should dredge and regulate, dispel stasis and generate new blood, and promote yang and transform turbidity. Therefore, for the first traditional Chinese medicine composition during the menstrual period of the present invention, Angelica sinensis and Ligusticum wallichii are used as the monarch drugs. Angelica sinensis promotes blood circulation and removes blood stasis, while Ligusticum wallichii promotes qi circulation in blood, relieves depression and pain, and is a qi drug in blood. The combination of the two promotes blood circulation and removes blood stasis. Salvia miltiorrhiza, Paeonia lactiflora, and Prunus persica are used as the ministerial drugs to assist the monarch drugs in promoting blood circulation to remove blood stasis and regulating qi and menstruation. Leonurus japonicus, Cyperus rotundus, Lindera aggregata, Cinnamomum cassia, Artemisia argyi, and Aucklandia lappa are used as the adjuvant drugs. Among them, Leonurus japonicus promotes blood circulation and regulates menstruation, and promotes diuresis and reduces swelling; Cyperus rotundus soothes the liver and relieves depression, and regulates qi and menstruation; Lindera aggregata warms the meridians and dispels cold; Cinnamomum cassia warms the meridians and dispels cold, promotes yang and transforms qi, and warms the kidney yang; Aucklandia lappa promotes qi circulation and relieves pain, and strengthens the spleen and stomach; Artemisia argyi warms the meridians and stops bleeding, and dispels cold and relieves pain. They are used together to assist the monarch drugs in warming the uterus and dispelling cold, and promoting the discharge of stasis. Licorice is used as the guiding drug to harmonize various drugs, eliminate the inferior properties of each drug, and improve the drug effect.

[0042] The late menstrual period is the stage of follicle growth and development. Therefore, during the late menstrual period, it is necessary to promote blood circulation and nourish blood, nourish yin and tonify the kidney to repair the endometrium and promote follicle growth and development. Therefore, the second traditional Chinese medicine composition is used for treatment during the late menstrual period. In the second traditional Chinese medicine composition, Angelica sinensis and Rehmannia glutinosa are used as the monarch drugs. Among them, Angelica sinensis promotes blood circulation and nourishes blood, and Rehmannia glutinosa nourishes blood and yin, benefits essence and fills the marrow. The combination nourishes yin and blood together to help increase the thickness of the endometrium. Polygonatum sibiricum, Cuscuta chinensis, Astragalus complanatus, Plantago asiatica, Lycium barbarum, Schisandra chinensis, and Trigonella foenum-graecum are used as the ministerial drugs to nourish yin and strengthen the kidney, assist the monarch drugs in nourishing eggs and increasing the endometrium, promote follicle growth and development, and improve the ovarian maturation rate. Among them, the diuretic and damp-discharging effect of Plantago asiatica is taken to assist the mature follicles to be discharged and combine with sperm. Paeonia lactiflora is used as the adjuvant and guiding drug to assist the monarch and ministerial drugs in nourishing eggs and increasing the endometrium.

[0043] The intermenstrual period, also known as the ovulatory period, during which the expulsion of the follicle (ovulation), its ease of fertilization, and the implantation of the fertilized egg need to be considered to ultimately achieve pregnancy promotion. Therefore, during the intermenstrual period, it is necessary to ensure smooth blood circulation to facilitate follicle maturation, and the follicle wall should be thin and easy to rupture to facilitate egg fertilization and the implantation of the fertilized egg. Thus, for the third traditional Chinese medicine composition during the intermenstrual period including the ovulatory period, turmeric, salvia miltiorrhiza, red peony root, and angelica sinensis are used as the monarch drugs, working together to break blood and promote blood circulation, promote blood circulation in the endometrium, promote follicle maturation and expulsion. Curcuma aromatica, cistanche deserticola, eucommia ulmoides, Chinese yam, and cinnamon are used as the minister drugs, working together to tonify yin and yang moderately, assisting the monarch drugs to promote follicle development and maturation, and facilitating the implantation of the fertilized egg embryo. Curcuma aromatica soothes the liver and regulates qi, cistanche deserticola tonifies kidney yang and nourishes essence and blood, eucommia ulmoides tonifies the liver and kidney, strengthens tendons and bones, and prevents miscarriage, Chinese yam regulates the spleen and stomach, and supplements nutrition for the fertilized egg (modern pharmacological research shows that Chinese yam is rich in various vitamins, minerals, etc.). Caulis spatholobi, caulis sargentodoxae, and eupatorium lindleyanum are used as assistant drugs, promoting blood circulation and nourishing blood, dredging meridians and collaterals, assisting the monarch and minister drugs to promote follicle expulsion, forming mucus in the shape of cervical os drawing (follicular fluid), facilitating the passage of mature follicles through the fallopian tube for fertilization, and creating a favorable environment for the smooth combination of sperm and eggs; Cyathula officinalis is used as the guiding drug to guide the medicine into the uterine cavity.

[0044] The beneficial effects achieved by the present invention are as follows:

[0045] The present invention follows the menstrual cycle regulation method of traditional Chinese medicine. Based on the physiological characteristics of the menstrual cycle and combining the characteristics of follicle growth, development, fertilization, and implantation in different stages of the menstrual cycle, the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition are respectively used for reasonable treatment in the three stages of the menstrual period, the postmenstrual period, and the intermenstrual period. Specifically, during the menstrual period (menstrual period), promoting blood circulation to remove blood stasis and warming yang to expel turbidity to turn yang into yin; during the postmenstrual period (follicular phase), nourishing yin and blood and nourishing eggs and thickening the endometrium; during the intermenstrual period (ovulatory period), tonifying both yin and yang and promoting blood circulation and dredging collaterals to turn yin into yang, so as to ultimately achieve regulating menstruation and promoting pregnancy. For women, especially older women over 30 with difficulties in getting pregnant, infertility, or adverse pregnancy outcomes, the treatment cycle is short and there are no side effects. Specific embodiments

[0046] In order to make the purpose, technical solutions, and advantages of the present invention clearer, the following further details the present invention in combination with its embodiments; it should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0047] Example 1: A traditional Chinese medicine for regulating menstruation and promoting pregnancy, which includes the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition;

[0048] The first traditional Chinese medicine composition is composed of raw materials with the following weights:

[0049] 10 parts of Angelica sinensis, 6 parts of Ligusticum wallichii, 9 parts of Prunus persica, 15 parts of Leonurus japonicus, 15 parts of Paeonia lactiflora, 15 parts of Salvia miltiorrhiza, 10 parts of stir-fried Artemisia argyi, 10 parts of Cyperus rotundus, 10 parts of Lindera aggregata, 10 parts of Aucklandia lappa, 10 parts of Cinnamomum cassia, 6 parts of Glycyrrhiza uralensis.

[0050] The second traditional Chinese medicine composition is composed of the following raw materials by weight:

[0051] 12 parts of Angelica sinensis, 12 parts of Paeonia lactiflora, 20 parts of Rehmannia glutinosa, 30 parts of Cuscuta chinensis, 15 parts of Astragalus complanatus, 15 parts of Plantago asiatica, 10 parts of Lycium barbarum, 10 parts of Schisandra chinensis, 15 parts of Trigonella foenum-graecum (also known as Fenugreek, Vanilla Seed), 15 parts of Polygonatum sibiricum.

[0052] The third traditional Chinese medicine composition is composed of the following raw materials by weight:

[0053] 15 parts of Angelica sinensis, 10 parts of Curcuma longa, 30 parts of Salvia miltiorrhiza, 15 parts of Paeonia lactiflora, 15 parts of Eupatorium lindleyanum, 15 parts of Cistanche deserticola, 15 parts of Eucommia ulmoides, 15 parts of Dioscorea opposita, 12 parts of Curcuma aromatica, 6 parts of Cinnamomum cassia, 15 parts of Spatholobus suberectus, 15 parts of Sargentodoxa cuneata, 15 parts of Cyathula officinalis.

[0054] Example 2: A traditional Chinese medicine for regulating menstruation and promoting pregnancy, which comprises a first traditional Chinese medicine composition, a second traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0055] The first traditional Chinese medicine composition is composed of the following raw materials by weight:

[0056] 6 parts of Angelica sinensis, 3 parts of Ligusticum wallichii, 6 parts of Prunus persica, 20 parts of Leonurus japonicus, 20 parts of Paeonia lactiflora, 20 parts of Salvia miltiorrhiza, 6 parts of Rhizoma Cyperi processed with vinegar, 6 parts of Radix Linderae Aggregata processed with vinegar, 6 parts of Aucklandia lappa, 6 parts of Cinnamomum cassia, 3 parts of Glycyrrhiza uralensis.

[0057] The second traditional Chinese medicine composition is composed of the following raw materials by weight:

[0058] 15 parts of Angelica sinensis, 3 parts of Ligusticum wallichii, 18 parts of Paeonia lactiflora, 20 parts of Rehmannia glutinosa, 20 parts of Cuscuta chinensis, 10 parts of Astragalus complanatus, 10 parts of Plantago asiatica, 10 parts of Lycium barbarum, 10 parts of Schisandra chinensis processed with salt, 10 parts of Trigonella foenum-graecum, 10 parts of Polygonatum sibiricum.

[0059] The third traditional Chinese medicine composition is composed of the following raw materials by weight:

[0060] 10 parts of Angelica sinensis, 5 parts of Curcuma longa, 15 parts of Salvia miltiorrhiza, 10 parts of Paeonia lactiflora, 10 parts of Eupatorium lindleyanum, 10 parts of Cistanche deserticola, 10 parts of Eucommia ulmoides, 10 parts of Dioscorea opposita, 10 parts of Curcuma aromatica, 3 parts of Cinnamomum cassia, 20 parts of Spatholobus suberectus, 20 parts of Sargentodoxa cuneata, 10 parts of Cyathula officinalis.

[0061] In specific applications, the traditional Chinese medicine of Example 1 and Example 2 can be prepared into capsules for easy taking.

[0062] Specifically, the preparation steps of the traditional Chinese medicine capsules of Example 1 and Example 2 are as follows:

[0063] S1: Process the raw medicinal materials;

[0064] In this step, Angelica sinensis and Ligusticum wallichii are stir-fried with wine; Lindera aggregata is stir-fried with vinegar; Prunus persica is stir-fried yellow with bran; Cyperus rotundus is stir-fried yellow with vinegar; Rehmannia glutinosa is steamed nine times in a pot by heating; Schisandra chinensis and Tribulus terrestris are stir-fried with salt.

[0065] S2: After separately pulverizing the raw medicinal materials, sieve them through 100 meshes;

[0066] S3: Take the raw medicinal materials in proportion and mix them, and then prepare the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition respectively;

[0067] S4: Just fill the separately prepared first traditional Chinese medicine composition, second traditional Chinese medicine composition, and third traditional Chinese medicine composition into capsules respectively.

[0068] Specifically, the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition can be filled into capsules of different colors for distinction. For example, the first traditional Chinese medicine composition is filled into red capsules, the second traditional Chinese medicine composition is filled into yellow capsules, and the third traditional Chinese medicine composition is filled into green capsules.

[0069] The filling amount of the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition in each capsule is 5 g.

[0070] Usage method:

[0071] The usage method of the traditional Chinese medicine in the capsule preparation of this embodiment is specifically as follows:

[0072] Start taking Jiaojing Cuyun Capsule No. I (red capsule) orally on the first day of menstruation, three times a day, three to five capsules each time.

[0073] Start taking Jiaojing Cuyun Capsule No. II (yellow capsule) orally in the late stage of menstruation, three times a day, three to five capsules each time.

[0074] Take Jiaojing Cuyun Capsule No. III (green capsule) orally during the intermenstrual period, three times a day, three to five capsules each time.

[0075] Continue to take the third traditional Chinese medicine composition for treatment during the premenstrual period until the next menstruation, or stop taking the medicine.

[0076] Toxicity experiment:

[0077] Purchase 40 adult Kunming mice (Supplier: Liaoning Changsheng Biotechnology Co., Ltd.), with half males and half females. Randomly divide them into four groups by drawing lots, namely Experimental Group 1, Experimental Group 2, Experimental Group 3, and Control Group.

[0078] Under normal feeding conditions, in the first experimental group, the first traditional Chinese medicine composition was intragastrically administered at a dose of 10 mg / kg per day, in the second experimental group, the second traditional Chinese medicine composition was intragastrically administered at a dose of 10 mg / kg per day, in the third experimental group, the third traditional Chinese medicine composition was intragastrically administered at a dose of 10 mg / kg per day, and the control group was intragastrically administered with normal saline, and the intragastric administration was carried out in two to three times a day.

[0079] On the third and seventh days after intragastric administration, the mental state, diet, and activity of the mice were observed, and three mice were randomly selected for dissection to observe the condition of the internal organs.

[0080] The mice in the first to third experimental groups and the control group were in a normal state on the third and seventh days, and there were no abnormalities in the internal organs.

[0081] Application cases.

[0082] The present invention has been applied to treat many people with difficulty in getting pregnant. According to the applicant's treatment experience using the present invention, in most people's menstrual cycles, the menstrual period is from 1 to 5 days of menstruation; in the postmenstrual period, it is from the 5th to 12th day of the menstrual cycle; in the intermenstrual period, which is also the ovulation period, it is about 13 to 18 days of the menstrual cycle; in the premenstrual period, it is about 19 to 28 days of the menstrual cycle. In specific treatment, on the basis of the above, the medication is adjusted adaptively according to the individual's menstrual cycle and the time of different stages.

[0083] The following is a typical case of treatment with the traditional Chinese medicine of Example 1.

[0084] Case 1: Wang XX, female, 38 years old. The initial diagnosis date was February 05, 2021, and the main complaint was infertility after 15 years of marriage;

[0085] Medical history:

[0086] Menstruation: Menarche at the age of 13, 3 - 5 days / 30 - 60 days, with less amount and dark color.

[0087] Usually, there is a dull pain in the lower abdomen, a large amount of leucorrhea, yellow in color and with an abnormal smell. The hands and feet are cold, the lower abdomen is cold, and she likes warmth. There is no breast distension before menstruation; the pain in the lower abdomen during menstruation is aggravated with soreness in the waist.

[0088] Last menstrual period: January 25, 2021;

[0089] In 2015, laparoscopy and hysteroscopy combined surgery was performed at the First Affiliated Hospital of Zhengzhou University: The fallopian tubes were patent but not smooth. Oral western medicine was taken for 3 months, but no pregnancy occurred.

[0090] In 2016, she was treated at Anyang People's Hospital for 6 months, but no pregnancy occurred.

[0091] In 2017, she took traditional Chinese medicine orally at Neihuang County Traditional Chinese Medicine Hospital for 6 months, but no pregnancy occurred.

[0092] There has been no further treatment in the past 5 years.

[0093] Past medical history: had been in good health.

[0094] Auxiliary examinations: The size of the uterus was normal, both adnexa were thickened, and there was 30 mm of pelvic effusion.

[0095] Both traditional Chinese and Western medicine diagnosed infertility.

[0096] After the initial diagnosis, the patient was given the third traditional Chinese medicine composition capsules for treatment.

[0097] On the second diagnosis on February 26, 2021, the lower abdominal pain improved significantly, the vaginal discharge decreased and had no odor. Menstruation occurred. Lmp: January 25th.

[0098] After the second diagnosis, the patient took the first traditional Chinese medicine composition capsules for treatment.

[0099] During the later stage of menstruation, the second traditional Chinese medicine composition was taken, and from the end of menstruation to the next menstrual period, the third traditional Chinese medicine composition capsules were continued to be taken.

[0100] On the third diagnosis on March 10, 2021, it was reported that the dysmenorrhea improved significantly. Lmp: March 4th.

[0101] After the third diagnosis, the patient continued to be treated with the first, second, and third traditional Chinese medicine compositions according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0102] On the fourth diagnosis on April 5, 2021, menstruation occurred during the fourth diagnosis. Lmp: April 5th; there was no obvious discomfort. The appetite was good, sleep was okay, and bowel and bladder movements were normal.

[0103] After the fourth diagnosis, the patient continued to be treated with the first, second, and third traditional Chinese medicine compositions according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0104] On the fifth diagnosis on June 9, 2021, Lmp: June 9th; Pmp: May 7th; tried to conceive this month

[0105] Ovulation period: June 22nd, 24th, 26th (had sexual intercourse).

[0106] The patient continued to be treated with the first, second, and third traditional Chinese medicine compositions according to the menstrual cycle. Stopped taking medicine during the premenstrual period.

[0107] On the sixth diagnosis on July 12, 2021, when visiting the doctor, the patient was not pregnant. Last menstrual period: July 12th.

[0108] After the sixth diagnosis, ovulation period: July 26th, 28th, 30th (had sexual intercourse).

[0109] And the patient continued to be treated with the first, second, and third traditional Chinese medicine compositions according to the menstrual cycle. Stopped taking medicine during the premenstrual period.

[0110] 7.24 Follicle monitoring by color Doppler ultrasound: 16x15mm

[0111] 7.26 Continue follicle detection: 18x19mm (instructed to have sexual intercourse).

[0112] On August 17, 2021, the seventh diagnosis, the menstruation was delayed for 5 days and did not come. Blood HCG and P indicated pregnancy.

[0113] Case 2: Jin Mou, female, 34 years old. The first diagnosis on September 4, 2022, chief complaint: poor pregnancy and childbirth, preparing to have a second child.

[0114] Situation of medical history taking:

[0115] At 8 weeks of pregnancy in 2020, the embryo stopped developing, and dilation and curettage was performed.

[0116] Menstruation started at the age of 12, and the menstrual cycle was regular. In the past 5 months, the menstrual cycle was 40 - 60 days, and the menstrual period was 3 - 5 days; the amount was small and the color was dark. There was a dull pain and distension in the lower abdomen during menstruation.

[0117] Last menstrual period: early July 2022.

[0118] The lower abdomen is cold, hands and feet are cold, and the buttocks are cold. The body is tired and weak, and it is easy to catch a cold. Poor sleep, not refreshed after waking up. Occasionally dizzy. Dry mouth. Bowel movement once every 2 - 3 days, not smooth, with a strong sense of falling.

[0119] The tongue is red, and the coating is peeled.

[0120] Urine pregnancy test (-).

[0121] Past history: Previous poor pregnancy and childbirth.

[0122] Diagnosis: Poor pregnancy and childbirth; Oligomenorrhea.

[0123] After the first diagnosis, the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition were taken for treatment according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken in the premenstrual period.

[0124] The second diagnosis on September 14, 2022, the menstruation has not come yet, and there is a slight breast distension. No other discomfort.

[0125] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken in the premenstrual period.

[0126] The third diagnosis on September 18, 2022, menstruation came today, lmp: 9.18; dull pain in the lower abdomen.

[0127] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken in the premenstrual period.

[0128] On the fourth diagnosis on January 10, 2023, after being infected with COVID-19, there were fever, spontaneous sweating, poor appetite, and loose stools. There was frequent urination and hematuria. The tongue coating was exfoliated. Lmp: December 20, 2022; Pmp: October 19, 2022;

[0129] After the fourth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle, and continuously take the third traditional Chinese medicine composition during the premenstrual period. After planning to condition for at least 3 months, prepare to conceive.

[0130] On the fifth diagnosis on May 11, 2023, the menstruation came on May 10 without obvious discomfort. Lmp: May 10; Pmp: April 5 / March 6 / January 28 (retrograde record of the last menstrual period).

[0131] After the fifth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine during the premenstrual period.

[0132] And the ovulation period: May 28, May 30, June 1 (having sexual intercourse)

[0133] On July 22, 2023, on the sixth diagnosis, the man had a cold from May to June and did not have sexual intercourse. Had sexual intercourse in July. Now the menstruation is postponed for 7 days and has not come yet, and the urine pregnancy test is (+), and she is already pregnant. Instructed to take traditional Chinese medicine to protect the fetus until 12 weeks of pregnancy.

[0134] Case 3: Gong Mou, female, 30 years old. The initial diagnosis date was January 2, 2023. When visiting the doctor, the main complaint was infertility 1 year after induced abortion.

[0135] Medical history inquiry: Delivered two girls by cesarean section in 2015 and 2019

[0136] At 8 weeks of pregnancy in 2017, there was a fetal arrest

[0137] At 5 weeks of pregnancy in 2022, there was a biochemical pregnancy, and at 9 weeks of pregnancy, there was an induced abortion; G5A2

[0138] Menstruation: 3 days / 30 days, the amount and color are okay, accompanied by severe dysmenorrhea and low back pain. The hands and feet are cold, and the lower abdomen is cold. Prone to oral ulcers 7 days before menstruation. Lmp: December 23, 2022

[0139] Usually dry mouth, no bad breath. Bowel movements and urination are normal. In the past year, there has been urgent urination, frequent urination and vulvar itching after sexual intercourse; the leucorrhea is large in amount, yellow in color, thick in texture, and occasionally has an odor.

[0140] Past medical history: Previous pregnancy-induced hypertension.

[0141] Diagnosed with secondary infertility.

[0142] After the initial diagnosis, take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0143] On the second diagnosis on February 19, 2023, menstruation occurred. LMP: 2.19; PMP: 1.19; There was internal heat and dry throat 7 days before menstruation.

[0144] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0145] On the third diagnosis on March 26, 2023, LMP: 3.19; Menstruation ended in 5 days. The tongue was red with yellow and greasy coating; There were acne on the lips.

[0146] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0147] On the fourth diagnosis on May 12, 2023, trying to conceive this month. Due to going out to work, taking medicine with her. Lmp: 4.16. Expected menstruation: 5.17.

[0148] After the fourth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking medicine during the premenstrual period.

[0149] Ovulation period: June 2, June 4, June 6 (having intercourse).

[0150] On the fifth diagnosis on June 14, 2023, menstruation occurred. Lmp: 6.14.

[0151] After the fifth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking medicine during the premenstrual period.

[0152] Ovulation period: June 30, July 2, July 4 (having intercourse)

[0153] On the sixth diagnosis on July 11, 2023, menstruation occurred. Lmp: 7.11.

[0154] After the sixth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking medicine during the premenstrual period.

[0155] On the seventh diagnosis on September 20, 2023, amenorrhea for 38 days, and blood HCG indicated pregnancy. Instructed to take traditional Chinese medicine to protect the fetus until 12 weeks of pregnancy.

[0156] Case 4: Yuan, female, 39 years old. The first diagnosis on March 6, 2022, with the main complaint of having had 3 times of adverse pregnancy outcomes.

[0157] Medical history inquiry: In 2019, at 4+ weeks of pregnancy, biochemical pregnancy

[0158] 2020, 8 weeks of pregnancy, fetal arrest

[0159] 2021, 8 weeks of pregnancy, fetal arrest, no fetal heartbeat

[0160] 2022.1 Menstruation was delayed for more than 10 days. Self-test of urine pregnancy (weak +?), blood progesterone: 10?; after curettage, it was suggested: endometrial polyp. Henan Provincial People's Hospital recommended assisted reproduction.

[0161] Menstruation: Cycle 28-32 days, menstrual period 5-7 days; normal volume, dark color, with blood clots. Occasionally dysmenorrhea; no lower abdomen coldness or cold hands and feet. Lmp: 2.16; Pmp: 1.12

[0162] The vaginal discharge is heavy, yellow, and has a foul odor. The stool is dry and the urine is yellow. There is sometimes bad breath. There is a noticeable beard around the lips.

[0163] The chromosomes of the couple are normal.

[0164] Past history: Past health.

[0165] Diagnose adverse pregnancy and delivery.

[0166] After the initial diagnosis, the first Chinese medicine composition, the second Chinese medicine composition and the third Chinese medicine composition are taken for treatment according to the menstrual cycle. The third Chinese medicine composition is taken continuously during the premenstrual period.

[0167] On the second visit on March 15, 2022, the bowel movement improved; the sleep was poor and dreamy. The vagina was occasionally dry. The amount of vaginal discharge was acceptable, without yellow discharge. The last menstrual period was March 13.

[0168] After the second visit, the first, second and third Chinese medicine compositions are continued to be taken according to the menstrual cycle for treatment. The third Chinese medicine composition is continued to be taken during the premenstrual period.

[0169] On April 20, 2022, the third visit, bowel movements were normal. Last menstrual period: April 20 (delayed for 7 days).

[0170] After the third visit, the first, second and third Chinese medicine compositions are continued to be taken according to the menstrual cycle for treatment. The third Chinese medicine composition is continued to be taken during the premenstrual period.

[0171] Fourth visit on May 19, 2022, menstruation came today, lmp: 5.19; trying to get pregnant this month.

[0172] After the fourth diagnosis, the patient continued to take the first, second and third Chinese medicine compositions according to the menstrual cycle for treatment. The medication was stopped during the premenstrual period.

[0173] Ovulation period: June 4, June 6, June 8 (intercourse).

[0174] The fifth diagnosis was on June 20, 2022. Menstruation occurred on June 19, lmp: 6.19; Continue to try to conceive this month.

[0175] After the fifth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine before menstruation.

[0176] Ovulation period: July 5, July 7, July 9 (intercourse).

[0177] The sixth diagnosis was on July 20, 2022. Menstruation has not occurred yet. Self-test urine pregnancy test was weakly positive.

[0178] On July 25: Self-test urine pregnancy test was positive; On August 3, the color Doppler ultrasound at the maternity and child care center showed early intrauterine pregnancy.

[0179] Instruct to take traditional Chinese medicine to protect the fetus until 12 weeks of pregnancy.

[0180] A baby girl was delivered vaginally on March 23, 2023.

[0181] A baby girl was delivered vaginally on September 27, 2024 (second child).

[0182] Case 5: Zhang, female, 32 years old. The first diagnosis was on April 4, 2022. Chief complaint: One case of adverse pregnancy and one case of ectopic pregnancy.

[0183] Medical history inquiry: In 2018, at 5 weeks of pregnancy, there was a biochemical pregnancy.

[0184] Hysterosalpingography: Obstruction of the left fallopian tube, the right side is normal.

[0185] Menstrual cycle disorder: Irregular, with cycles of 30 - 35 - 40 - 60 days; Menstrual period is 7 days. Menstrual volume is moderate, color is red, with blood clots. Breast distension pain, lower abdominal pain, and irritability before menstruation. Lower abdominal pain on the 1st - 2nd day of menstruation. Feet are cold. Appetite is good, digestion is normal. Sleep is normal. Bowel movements are regular, urine is red, hot, and yellow in color. Leukorrhea volume is moderate, occasionally yellow in color, no vulvar pruritus, occasionally with an odor. Last menstrual period (lmp): 3.3; pmp: 1.20. Auxiliary examination: Color Doppler ultrasound shows that the cervix is of normal size and smooth, without contact bleeding. There is no tenderness in both adnexa.

[0186] Past medical history: History of previous ectopic pregnancy; Gravida 2, Para 0.

[0187] Diagnosis: Adverse pregnancy and childbirth.

[0188] After the first diagnosis, take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continue to take the third traditional Chinese medicine composition before menstruation.

[0189] The second diagnosis was on April 9, 2022. There was no discomfort after taking the medicine. Menstruation occurred. Today is the 4th day of menstruation and it has not completely stopped. lmp: 4.5; Abdominal pain was obvious on the 1st - 2nd day of menstruation, buttocks were cold, feet were cold.

[0190] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0191] On the third diagnosis on April 23, 2022, it was reported that there were no adverse reactions.

[0192] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0193] On the fourth diagnosis on May 2, 2022, amenorrhea for 47 days, urine pregnancy test (+). No obvious discomfort. Case 6: Ms. Jian, female, 32 years old. First diagnosis on December 11, 2021, chief complaint: unable to conceive after 1 year of marriage without contraception.

[0194] Medical history inquiry: Usually, the menstrual cycle is irregular, occurring every 2 - 3 months, or even every six months. There is strong discomfort in the lower abdomen before menstruation, without dysmenorrhea. Last menstrual period: 12.10 (60 - day cycle)

[0195] In 2020, at Henan Provincial Hospital of Traditional Chinese Medicine, oral traditional Chinese medicine was taken to regulate menstruation to occur once every two months. Color Doppler ultrasound showed no abnormalities in the uterus and bilateral adnexa. Sex hormone six - item test: normal. Semen analysis of the male partner was normal.

[0196] Five months ago, at Henan Provincial Hospital of Traditional Chinese Medicine, a clomiphene citrate + HMG injection ovulation - induction protocol was carried out for 3 months, without dominant follicles and without pregnancy.

[0197] Sleep is light and easy to wake up. Appetite is okay; bowel movements and urination are normal.

[0198] Past medical history: Previously in good health.

[0199] Diagnosis: Infertility.

[0200] After the first diagnosis, take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0201] On December 14, 2021, it was reported that there was no discomfort after taking the medicine.

[0202] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0203] On the third diagnosis on January 11, 2022, menstruation occurred today; LMP: 1.11.

[0204] Observe the menstrual situation next month. If not pregnant, check the fallopian tube condition.

[0205] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine before menstruation.

[0206] Ovulation period: January 30th, February 1st, February 3rd (sexual intercourse).

[0207] On the fourth diagnosis on February 20, 2022, the patient contacted via WeChat. The menstruation did not occur, and the urine pregnancy test was (+).

[0208] On November 24, 2022, a baby boy was delivered smoothly.

[0209] Case 7: Han XX, female, 23 years old. On December 11, 2021, the chief complaint was difficulty in getting pregnant.

[0210] Medical history inquiry: Menstruation: 6 - 7 days / 37 - 40 days, menstrual cycle irregular, amount less, color dark, no blood clots. Waist cold, buttocks cold, limbs not warm. Lmp: November 8th; urine pregnancy test (-); vaginal discharge amount moderate, no odor, no vulvar itching; appetite and sleep normal, bowel and bladder movements regular.

[0211] Auxiliary examination: Six - item sex hormone test: Testosterone is on the high side, the rest are normal; Color Doppler ultrasound: Uterus and adnexa are normal.

[0212] Past medical history: Previously in good health.

[0213] Traditional Chinese medicine diagnosis: Uterine cold syndrome.

[0214] After the first diagnosis, take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the pre - menstrual period.

[0215] On the second diagnosis on December 27, 2021, menstruation occurred today, lmp: December 27th; slight pain in the lower abdomen, no other discomfort.

[0216] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine before menstruation.

[0217] Ovulation period: January 15th, January 17th, January 19th, 2022 (sexual intercourse).

[0218] On the third diagnosis on January 9, 2022, it was reported that there was no discomfort during taking the medicine.

[0219] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the pre - menstrual period.

[0220] On the fourth diagnosis on February 9, 2022, the menstruation did not occur before the fourth diagnosis, and only the third traditional Chinese medicine composition was used for treatment.

[0221] Color Doppler ultrasound shows: early intrauterine pregnancy, consistent with 5+ weeks of gestation.

[0222] Case 8: Dong, female, 21 years old. First diagnosis on November 23, 2019. Chief complaint: not using contraception for 2 years and not being pregnant.

[0223] Medical history inquiry:

[0224] Pregnant for 8 weeks in 2017, with fetal arrest.

[0225] Menstruation is usually delayed, once every 35 days. Menstrual period is 5 - 7 days, the amount and color of menstrual blood are normal; there is soreness in the waist during menstruation. Usually, hands and feet are cold.

[0226] Lmp: 11.16

[0227] In Neihuang County Hospital in March 2019: The six - item sex hormone is basically normal;

[0228] Hysteroscopy was performed in the First Affiliated Hospital of Zhengzhou University in August 2019: The uterine cavity morphology is normal; both fallopian tubes are unobstructed. The karyotypes of both parties are normal.

[0229] Auxiliary examination: Color Doppler ultrasound: The size of the uterus is normal, bilateral ovaries show polycystic changes, and there is a small amount of pelvic effusion

[0230] Gynecological examination: The cervix is of normal size, there is no tenderness in bilateral adnexa; viscous secretions can be seen in the vagina

[0231] Past medical history: Healthy.

[0232] Diagnosis: Infertility.

[0233] After the first diagnosis, the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition were taken according to the menstrual cycle for treatment. The third traditional Chinese medicine composition was continuously taken in the pre - menstrual period.

[0234] Second diagnosis on November 29, 2019. After taking the medicine, there is no discomfort, the bowel movement is regular, once a day, and formed.

[0235] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle for treatment. The third traditional Chinese medicine composition was continuously taken in the pre - menstrual period.

[0236] Third diagnosis on December 12, 2019. Menstruation has not come yet, no breast distension. Occasionally, there is soreness in the waist.

[0237] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle for treatment. The third traditional Chinese medicine composition was continuously taken in the pre - menstrual period.

[0238] Fourth diagnosis on December 24, 2019. Menstruation still has not come yet, lmp: 11.16.

[0239] After the four diagnostic methods, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0240] On the fifth diagnosis on December 28, 2019, menstruation came today: lmp: 12.28 (42-day cycle).

[0241] After the fifth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0242] On the sixth diagnosis on January 14, 2020.

[0243] After the sixth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking medicine during the premenstrual period.

[0244] Ovulation period: 1.15, 1.17, 1.19 (sexual intercourse).

[0245] On the seventh diagnosis on February 7, 2020, contacted by WeChat: Menstruation was delayed for more than 10 days and did not come; self-tested urine pregnancy (weak +).

[0246] Instructed: Stay in bed and rest quietly; take traditional Chinese medicine for fetal protection intermittently (during the epidemic).

[0247] On March 7, 2020, color Doppler ultrasound: 7+ weeks of pregnancy, fetal heart visible. Seek medical advice if unwell.

[0248] Case 9: Xu, female, 34 years old. The first diagnosis on August 14, 2023, chief complaint: Preparing for a second child, having difficulty getting pregnant.

[0249] Medical history inquiry: 2 pregnancies, 1 childbirth, 1 induced abortion (gave birth to a son naturally)

[0250] Usually has regular menstruation, cycle 28 days, menstrual period 3 - 4 days, amount and color are normal, no discomfort during menstruation;

[0251] lmp: 7.25; constipation; sleep is okay, appetite is okay.

[0252] Auxiliary examination: Color Doppler ultrasound shows: linear echo in the right fallopian tube; OGTT: impaired glucose tolerance;

[0253] Past medical history: History of hyperglycemia

[0254] Diagnosed with infertility.

[0255] After the first diagnosis, take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0256] On the second diagnosis on August 23, 2023, consulted by WeChat: No discomfort after taking medicine, occasional breast distension.

[0257] After the second diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0258] On the third diagnosis on September 6, 2023, through WeChat consultation: LMP: 8.29; no discomfort during menstruation. Vulvar pruritus after menstruation.

[0259] After the third diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Continuously take the third traditional Chinese medicine composition during the premenstrual period.

[0260] On the fourth diagnosis on October 3, 2023, LMP: 9.24; requests to try pregnancy this month.

[0261] After the fourth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine during the premenstrual period.

[0262] Ovulation period: October 6, 8, 10 (sexual intercourse).

[0263] On the fifth diagnosis on October 23, 2023, through WeChat consultation: LMP: 10.20; no discomfort during menstruation.

[0264] After the fifth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine during the premenstrual period.

[0265] Ovulation period: November 2, 4, 6 (sexual intercourse).

[0266] On the sixth diagnosis on November 17, 2023, through WeChat consultation: Menstruation has come today, LMP: 11.17.

[0267] After the sixth diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle. Stop taking the medicine during the premenstrual period.

[0268] Ovulation period: November 29, December 1, 3 (sexual intercourse).

[0269] On the seventh diagnosis on January 20, 2024, LMP: 1.18; PMP: 12.18.

[0270] After the seventh diagnosis, continue to take the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition for treatment according to the menstrual cycle.

[0271] On the eighth diagnosis on March 19, 2024, by color Doppler ultrasound: A gestational sac with a size of about 10.4x28 mm can be detected in the uterus.

[0272] Case 10: Zuo, female, 30 years old. First diagnosis on June 5, 2023. Chief complaint: Not pregnant after 2 years of unprotected intercourse.

[0273] Medical history inquiry: Menstruation: Menarche at 12 years old, 7 days / 28 - 33 days; Moderate amount, bright red color, lower abdominal distension during menstruation; LMP: May 15th.

[0274] Auxiliary examinations: Hysterosalpingography: Both fallopian tubes are basically unobstructed; Pelvic local adhesion cannot be excluded. AMH: 5.22; Thyroid function is normal, OGTT and insulin release test: Normal;

[0275] Past medical history: Hyperandrogenism.

[0276] Diagnosis: Infertility (phlegm-dampness obstruction in the uterus).

[0277] After the first diagnosis, the patient was treated with the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0278] Second diagnosis on June 15, 2023. Menstruation came on June 14th, LMP: June 14th.

[0279] After the second diagnosis, the patient continued to be treated with the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0280] Third diagnosis on July 3, 2023. No discomfort after taking the medicine, defecation once a day, slightly loose.

[0281] After the third diagnosis, the patient continued to be treated with the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0282] Fourth diagnosis on July 17, 2023. Menstruation came yesterday, LMP: July 16th; Lower abdominal distension and discomfort.

[0283] After the fourth diagnosis, the patient continued to be treated with the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle. The third traditional Chinese medicine composition was continuously taken during the premenstrual period.

[0284] Fifth diagnosis on August 17, 2023. LMP: August 14th;

[0285] After the fifth diagnosis, the patient continued to be treated with the first traditional Chinese medicine composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition according to the menstrual cycle. Stopped taking the medicine during the premenstrual period.

[0286] Ovulation period: August 30th, September 2nd, September 4th (sexual intercourse)

[0287] Sixth diagnosis on November 26, 2023. Consultation via WeChat: 8 + weeks pregnant.

[0288] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A traditional Chinese medicine for regulating menstruation and promoting pregnancy, characterized in that, It includes a first traditional Chinese medicine composition, a second traditional Chinese medicine composition and a third traditional Chinese medicine composition; The first traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 5 - 15 parts, Ligusticum wallichii 3 - 10 parts, Prunus persica 6 - 20 parts, Leonurus japonicus 10 - 20 parts, Paeonia lactiflora 10 - 20 parts, Salvia miltiorrhiza 10 - 20 parts, stir-fried Artemisia argyi 8 - 15 parts, Cyperus rotundus 5 - 15 parts, Lindera aggregata 5 - 15 parts, Aucklandia lappa 5 - 15 parts, Cinnamomum cassia 5 - 15 parts, Glycyrrhiza uralensis 3 - 10 parts; The second traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 8 - 18 parts, Paeonia lactiflora 8 - 18 parts, Rehmannia glutinosa 12 - 25 parts, Cuscuta chinensis 20 - 40 parts, Astragalus complanatus 10 - 20 parts, Plantago asiatica 10 - 20 parts, Lycium barbarum 5 - 15 parts, Schisandra chinensis 5 - 15 parts, Trigonella foenum-graecum 10 - 20 parts, Polygonatum sibiricum 10 - 20 parts; The third traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 10 - 20 parts, Curcuma longa 5 - 15 parts, Salvia miltiorrhiza 20 - 40 parts, Paeonia lactiflora 10 - 20 parts, Eupatorium lindleyanum 10 - 20 parts, Cistanche deserticola 10 - 20 parts, Eucommia ulmoides 10 - 20 parts, Dioscorea opposita 10 - 20 parts, Curcuma aromatica 8 - 20 parts, Cinnamomum cassia 3 - 15 parts, Spatholobus suberectus 10 - 20 parts, Sargentodoxa cuneata 10 - 20 parts, Cyathula officinalis 10 - 20 parts.

2. The traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 1, wherein The first traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 10 parts, Ligusticum wallichii 6 parts, Prunus persica 9 parts, Leonurus japonicus 15, Paeonia lactiflora 15 parts, Salvia miltiorrhiza 15 parts, stir-fried Artemisia argyi 10 parts, Cyperus rotundus 10 parts, Lindera aggregata 10 parts, Aucklandia lappa 10 parts, Cinnamomum cassia 10 parts, Glycyrrhiza uralensis 6 parts.

3. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 1, wherein The second traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 12 parts, Paeonia lactiflora 12 parts, Rehmannia glutinosa 20 parts, Cuscuta chinensis 30 parts, Astragalus complanatus 15 parts, Plantago asiatica 15 parts, Lycium barbarum 10 parts, Schisandra chinensis 10 parts, Trigonella foenum-graecum 15 parts, Polygonatum sibiricum 15 parts.

4. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 1, wherein The third traditional Chinese medicine composition is composed of raw materials in the following weights: Angelica sinensis 15 parts, Curcuma longa 10 parts, Salvia miltiorrhiza 30 parts, Paeonia lactiflora 15 parts, Eupatorium lindleyanum 15 parts, Cistanche deserticola 15 parts, Eucommia ulmoides 15 parts, Dioscorea opposita 15 parts, Curcuma aromatica 12 parts, Cinnamomum cassia 6 parts, Spatholobus suberectus 15 parts, Sargentodoxa cuneata 15 parts, Cyathula officinalis 15 parts.

5. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to any one of claims 1 to 4, wherein The first traditional Chinese medicine composition, the second traditional Chinese medicine composition and the third traditional Chinese medicine composition are respectively added with pharmaceutically acceptable adjuvants to prepare oral preparations.

6. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 5, wherein The oral preparation is a capsule, a tablet, an oral solution or a pill.

7. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 6, wherein When the oral preparation is a capsule, its preparation method includes the following steps: S1: Process the raw drugs; S2: After separately pulverizing the raw drugs, sieve them through 100 meshes; S3: Take the raw drugs in proportion and mix them, and respectively prepare the first traditional Chinese medicine composition, the second traditional Chinese medicine composition and the third traditional Chinese medicine composition; S4: Just fill the separately prepared first traditional Chinese medicine composition, second traditional Chinese medicine composition, and third traditional Chinese medicine composition into capsules respectively.

8. A traditional Chinese medicine for regulating menstruation and promoting pregnancy according to claim 7, characterized in that The specific operations for the processing of the medicine in step S1 are as follows: Angelica sinensis in the first traditional Chinese medicine composition and the second traditional Chinese medicine composition is stir-fried with wine; Ligusticum chuanxiong in the first traditional Chinese medicine composition is stir-fried with wine, and Lindera aggregata is stir-fried with vinegar; Peach kernels in the first traditional Chinese medicine composition are stir-fried yellow with bran heating; Cyperus rotundus in the first traditional Chinese medicine composition is stir-fried yellow with vinegar; Prepared rehmannia root in the second traditional Chinese medicine composition is steamed nine times in a pot by heating; Schisandra chinensis in the second traditional Chinese medicine composition is stir-fried with salt, and Trigonella foenum-graecum seeds are stir-fried with salt; 9. Use of the traditional Chinese medicine for regulating menstruation and promoting pregnancy according to any one of claims 1 to 8 in the preparation of a drug for treating / assisting in treating infertility or adverse pregnancy outcomes.