Microbubble control method, device, equipment, medium and product

Abstract

The invention provides a microbubble control method and device, equipment, a medium and a product, a preset first mapping relation is obtained, the first mapping relation comprises the corresponding relation among opening orientations of multiple microbubble structures, the sizes of multiple openings, multiple ultrasonic frequencies and multiple flow field directions, the flow field directions are the flowing directions of fluid, and the flow field directions are different. The ultrasonic frequency is the frequency of ultrasonic waves applied to the microbubble structure; obtaining a preset second mapping relation, wherein the second mapping relation comprises a one-to-one correspondence relation between the opening sizes of the plurality of microbubble structures and the sizes of the plurality of target substances; obtaining a target size of a target substance and a target delivery position of the target substance; and delivering the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship. The embodiment of the invention can improve the delivery effect of the target substance.

Description

Technical Field

[0001] The present application relates to the field of ultrasonic control technology, and particularly to a microbubble control method, device, equipment, medium and product. Background Art

[0002] Malignant tumors are one of the important diseases that seriously endanger people's lives and health. Traditional cancer treatment methods do not have the functions of precision and targeting, and often cause certain harm to patients during treatment. How to quickly and controllably deliver drug payloads to the lesion area in extremely small blood vessels has become an important clinical problem in cancer treatment. Studying and solving this problem has broad medical and economic prospects.

[0003] In the prior art, the method of magnetic field driving and controlling is usually used to deliver drugs in blood vessels. However, due to limitations such as the large size of the control system device, inability to miniaturize, difficulty in integrating with microfluidic chips, and specific requirements for the driving object, the drug delivery effect of the current magnetic field driving method is not ideal. Summary of the Invention

[0004] A microbubble control method, device, equipment, medium and product provided by the present application can improve the delivery effect of target substances.

[0005] In a first aspect, an embodiment of the present application provides a microbubble control method, which is applied to a microbubble structure. The microbubble structure is arranged in a microchannel structure, and fluid flows in the microchannel structure. The microbubble structure is used to deliver a target substance. The method includes:

[0006] Obtain a preset first mapping relationship, where the first mapping relationship includes the corresponding relationship between the opening directions of a plurality of microbubble structures, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions. The flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure;

[0007] Obtain a preset second mapping relationship, where the second mapping relationship includes the one-to-one correspondence between the opening sizes of a plurality of microbubble structures and the size sizes of a plurality of target substances;

[0008] Obtain the target size of the target substance and the target delivery position of the target substance;

[0009] Based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, deliver the target substance to the target position.

[0010] In a second aspect, the present application provides a microbubble control device, which is applied to a microbubble structure. The microbubble structure is arranged in a microchannel structure, and fluid flows in the microchannel structure. The microbubble structure is used to deliver a target substance. The device includes:

[0011] A first acquisition module, configured to acquire a preset first mapping relationship, where the first mapping relationship includes the corresponding relationship between the opening directions of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions, the flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure;

[0012] A second acquisition module, configured to acquire a preset second mapping relationship, where the second mapping relationship includes the one-to-one corresponding relationship between multiple opening sizes of the microbubble structures and the size of multiple target substances;

[0013] A third acquisition module, configured to acquire the target size of the target substance and the target delivery position of the target substance;

[0014] A delivery module, configured to deliver the target substance to the target position based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship.

[0015] In a third aspect, an embodiment of the present application provides an electronic device, which includes: a processor and a memory storing computer program instructions;

[0016] When the processor executes the computer program instructions, it implements the microbubble control method in any one of the embodiments in the first aspect.

[0017] In a fourth aspect, an embodiment of the present application provides a computer storage medium, on which computer program instructions are stored, and when the computer program instructions are executed by a processor, the microbubble control method in any one of the embodiments in the first aspect is implemented.

[0018] In a fifth aspect, an embodiment of the present application provides a computer program product, and when the instructions in the computer program product are executed by the processor of the electronic device, the electronic device is caused to execute and implement the microbubble control method in any one of the embodiments in the first aspect above.

[0019] In a microbubble control method, device, equipment, medium and product provided by an embodiment of the present application, by obtaining a preset first mapping relationship, the first mapping relationship includes the corresponding relationship between the opening directions of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions, the flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure; obtaining a preset second mapping relationship, the second mapping relationship includes the one-to-one correspondence between the opening sizes of multiple microbubble structures and the size of multiple target substances; obtaining the target size of the target substance and the target delivery position of the target substance; based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, delivering the target substance to the target position. In the above manner, by obtaining the corresponding relationship between the opening direction, size and ultrasonic frequency of the microbubble structure and the flow field direction, highly precise control of fluid flow is achieved. It ensures the accurate transportation of drugs in the microchannel structure and can quickly and intuitively adapt to the microenvironment. Using the second mapping relationship, the opening size of the microbubble structure is made to correspond one-to-one with the size of different target substances, realizing the matching delivery of target substances of different sizes, so that it can be applicable to a variety of target substances of different sizes, improving the flexibility and applicability of the delivery, and thus improving the delivery effect of the target substance. Description of the Drawings

[0020] To more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the drawings required to be used in the embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other drawings can also be obtained based on these drawings.

[0021] Figure 1 is a schematic flowchart of a microbubble control method provided by an embodiment of the present application;

[0022] Figure 2 is a schematic diagram of the distribution of the flow field at different ultrasonic frequencies, different opening sizes and different opening directions provided by an embodiment of the present application;

[0023] Figure 3 is a schematic diagram of the relationship between the opening diameter of a microbubble and the delivery efficiency provided by an embodiment of the present application;

[0024] Figure 4 is a schematic diagram of the screening of particles of different particle sizes by a microvortex provided by an embodiment of the present application;

[0025] Figure 5 is a schematic diagram of the structure of a microbubble structure provided by an embodiment of the present application;

[0026] Figure 6 It is a schematic structural diagram of another microbubble structure provided by an embodiment of the present application;

[0027] Figure 7 It is a schematic structural diagram of another microbubble structure provided by an embodiment of the present application;

[0028] Figure 8 It is a schematic structural diagram of a microbubble control device provided by an embodiment of the present application;

[0029] Figure 9 It is a schematic structural diagram of an electronic device provided by an embodiment of the present application. Detailed implementation manners

[0030] In order to more clearly understand the above objects, features and advantages of the present disclosure, the solutions of the present disclosure will be further described below. It should be noted that, without conflict, the embodiments of the present disclosure and the features in the embodiments may be combined with each other.

[0031] Many specific details are set forth in the following description in order to fully understand the present disclosure, but the present disclosure may be implemented in other ways different from those described herein; obviously, the embodiments in the specification are only a part of the embodiments of the present disclosure, rather than all the embodiments.

[0032] It should be noted that, in this text, relational terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements includes not only those elements, but also other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the phrase "comprising a..." does not exclude the existence of additional identical elements in the process, method, article or device comprising the element.

[0033] Malignant tumors are one of the important diseases that seriously endanger people's lives and health. Traditional cancer treatment methods do not have the functions of precision and targeting, and often cause certain harm to patients during treatment. How to quickly and controllably deliver drug payloads to the lesion area in extremely small blood vessels has become an important clinical problem in cancer treatment. Studying and solving this problem has broad medical and economic prospects. Due to the influence of the low Reynolds number effect at the microscale, microfluidics exhibits relatively high viscosity, and traditional convection and diffusion cannot achieve a satisfactory net flow effect. Currently, methods for generating a net driving force at the microscale include external magnetic field and acoustic field control methods. The external magnetic field control method can generate controllable motion in terms of direction and velocity in microfluidics by combining structures such as spirals. The external acoustic field control method is an effective, fast, and high-intensity driving and control method. Methods for generating high-intensity microvortices at the microscale include microbubbles and sharp-edge structures. Under the action of the acoustic field, microbubbles can generate a pair of symmetric microvortices at the gas-liquid interface of the bubbles; due to micro-perturbations, the sharp-edge structure can also generate a good microfluidic effect under the drive of the acoustic field.

[0034] Currently, the driving method of the magnetic field has limitations such as the large size of the control system device, inability to be miniaturized, difficulty in integrating with microfluidic chips, and specific requirements for the driving object. Compared with the magnetic field driving and control method, microscale ultrasonic driving and control has greater portability, high energy intensity, can be integrated on-chip, and is easy to miniaturize, which is favored by the academic and business communities. Ultrasonic frequency, ultrasonic amplitude, and ultrasonic phase are the main ultrasonic driving and control means. However, currently, the sharp-edge structure of ultrasonic driving and control does not have frequency specificity in microfluidics, and only shows a monotonic negative correlation between vortex intensity and frequency. The acoustic driving and control means at the microscale are relatively single. Microbubbles are an excellent acoustic driving and control carrier with frequency specificity, but their frequency difference responsiveness requires a large difference in bubble size. In addition, the regulation of microbubbles mainly focuses on intensity regulation, which is used for microscale mixing, aggregation, and screening, etc. The microscale microvortices generated by them are symmetric and cannot generate a net flow. Therefore, currently, there is a lack of methods for generating asymmetric acoustic streaming at the microscale, a lack of frequency-specific driving methods for microbubble arrays with similar sizes, and selective delivery and screening applications based on frequency-specific driving methods. By enriching the driving and control methods of microscale acoustics, it has potential applications in microfluidic driving, microfluidic direction selection, and selective screening under a specific microfluidic direction.

[0035] In order to solve the problems existing in the prior art, the embodiments of the present application provide a microbubble control method, device, equipment, medium, and product.

[0036] The embodiments of the present application provide a microbubble control method, device, equipment, medium, and product. First, the microbubble control method provided by the embodiments of the present application will be introduced as follows. As Figure 1As shown, this method is applied to a microbubble structure, which is disposed in a microchannel structure, where fluid flows in the microchannel structure, and the microbubble structure is used to deliver a target substance. The method specifically includes the following steps:

[0037] S100, obtain a preset first mapping relationship, where the first mapping relationship includes the corresponding relationship between the opening orientations of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions. The flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure.

[0038] Optionally, in the embodiments of the present application, a microbubble structure refers to a structure formed by small gas-encapsulated bubbles at the microscale. These tiny bubbles can be embedded in a liquid or other medium and have sizes ranging from micrometers to millimeters. The microbubble structure can generate a microfluidic effect in an ultrasonic field for drug delivery, mixing, or other microscale operations.

[0039] A microchannel structure refers to a channel or pipeline formed at the microscale, and its size is usually at the micrometer level. These microchannels can be composed of a microfluidic chip, a microfluidic device, or other microsystem components. The design of the microchannel structure can achieve precise manipulation and analysis of trace amounts of liquid. Among them, the fluid flowing in the microchannel can be a liquid. This liquid can include solutions, suspensions, or other forms of fluid media. The fluid in the microchannel can be subjected to external excitation, such as ultrasonic waves, to achieve precise flow control and drug delivery.

[0040] Optionally, in the embodiments of the present application, a target substance refers to the main object or the substance of concern in a specific application scenario, that is, the target substance is the substance that needs to be delivered through the microbubble structure and may be involved in fields such as medicine, drug delivery, and biology. The target substance can be various substances, specifically depending on the research or application requirements. For example, the target substance can be various drugs, substances used to treat diseases or achieve therapeutic effects; for another example, the target substance can be a biomarker in the body, used to detect, label, or study biological processes; the target substance may also be cells, used for specific cell therapy or research; the target substance can be nanoparticles, used for delivery, loading, or research at the nanoscale; the target substance may include various biomolecules, such as proteins, nucleic acids, etc., used for biomedical research or treatment; the target substance can also be a fluorescent marker, used for biological imaging or tracking specific molecules.

[0041] Optionally, in a feasible implementation manner of the present application, a series of experiments can be first carried out to obtain data by observing the behavior of the microbubble structure under different conditions. For example, the movement of microbubbles in an ultrasonic field can be observed through a microscope, and the behavior under different ultrasonic frequencies, different opening sizes, and different flow field directions can be recorded. Or, computational fluid dynamics or other numerical simulation methods can be used to simulate the behavior of microbubbles under different conditions in a computer. By adjusting parameters such as ultrasonic frequency, opening size, and flow field direction, a series of simulation data can be generated. Finally, after obtaining these experimental data or simulation data, the relationship between the opening orientation, opening size, ultrasonic frequency, and flow field direction of the microbubble structure can be determined through statistical analysis or establishing a mathematical model to form a first mapping relationship. This relationship will provide a basis for subsequent applications to better control the behavior of the microbubble structure under specific conditions.

[0042] S200, obtain a preset second mapping relationship, where the second mapping relationship includes the one-to-one correspondence between the opening sizes of multiple microbubble structures and the size of multiple target substances.

[0043] Optionally, in a feasible implementation manner of the present application, a series of experiments can also be first carried out to obtain data by measuring the opening size of the microbubble structure and the size of the target substance. Tools such as a microscope can be used to measure the specific characteristics of the microbubbles, and at the same time, the size information of the target substance can be obtained through experimental means.

[0044] Or image processing and analysis techniques can be used to process the images of the microbubble structure and the target substance. In this way, the opening size of the microbubbles and the size of the target substance can be quantified, and the relationship between them can be established. Or computational methods can also be used to simulate the behavior of the microbubble structure and the target substance in a computer through a numerical simulation tool. By adjusting parameters such as the opening size, a series of simulation data can be generated and their correlations can be analyzed.

[0045] Through the above methods, data on the relationship between the opening size of the microbubble structure and the size of the target substance can be collected. These data can be used to establish a second mapping relationship, providing a basis for subsequent applications to better control the effect of the microbubble structure when delivering the target substance.

[0046] S300, obtain the target size of the target substance and the target delivery position of the target substance.

[0047] Optionally, in a specific implementation manner of this application, assuming that the target substance is a drug, medical imaging techniques such as magnetic resonance imaging and computed tomography can be used to obtain detailed information such as the morphology and size of the lesion or target tissue. This information can be used as a basis for the target size and delivery location of the target substance. Pathological tests can also be performed on the patient to obtain detailed information about the target tissue through histological analysis, including cell structure, size, etc., which also helps to determine the delivery location and size of the target substance. It is also possible to rely on the clinical diagnosis of clinicians. Combining the patient's medical history, symptoms, etc., the lesion location and size can be initially determined as the basis for the delivery of the target substance.

[0048] In other embodiments, in medical imaging, contrast agents or marker substances can be used to highlight the lesion, so as to more clearly observe the location and size of the target tissue. Or, based on the patient's individual data, including physiological parameters and pathological characteristics, computational models or algorithms can be used for prediction to obtain the target size and delivery location of the target substance. Through these methods, information on the target size and delivery location of the target substance can be obtained to varying degrees to guide the drug delivery plan.

[0049] Optionally, in another implementation manner of this application, for living cells, live cell microscopy and fluorescence imaging techniques can be used to monitor the distribution of the marker in the cell, and the cell morphology and the position of the marker can be observed. For fluorescent markers, the marker can be associated with spatial markers in the cell or tissue, such as cell organs or cell membranes. By observing the position of the marker relative to these structures, the delivery location of the marker can be indirectly understood.

[0050] S400, based on the first matching relationship between the target delivery location and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, deliver the target substance to the target location.

[0051] Optionally, in a specific implementation manner of this application, first, appropriate measurement means can be used to obtain the actual size of the target substance, such as particle size, cell diameter, etc. And according to specific requirements and treatment goals, determine the ideal delivery position of the target substance in the microchannel structure, which can be the lesion area or other specific positions that need treatment. Subsequently, through experiments or literature research, establish the relationship between the target delivery position and the opening orientation, opening size, ultrasonic frequency, and flow field direction of the microbubble structure. This can be an empirical matching relationship obtained through multiple experiments. Subsequently, an appropriate ultrasonic frequency, microbubble opening orientation, size, and flow field direction can be selected according to the first matching relationship to generate a flow field effect applicable to the target delivery position. Finally, through the action of ultrasonic waves, the microbubble structure generates a fluid flow field in the microchannel structure, and delivers the target substance along a predetermined path to the target position. Through this process, according to the size and delivery position of the target substance, the microbubble structure can be driven by ultrasonic waves to accurately deliver the target substance to the target position, thereby improving the delivery effect.

[0052] In a microbubble control method provided by an embodiment of this application, by obtaining a preset first mapping relationship, the first mapping relationship includes the corresponding relationship between the opening orientations of multiple microbubble structures, multiple opening sizes, multiple ultrasonic frequencies, and multiple flow field directions. The flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure; obtain a preset second mapping relationship, the second mapping relationship includes the one-to-one corresponding relationship between the opening sizes of multiple microbubble structures and the size sizes of multiple target substances; obtain the target size of the target substance and the target delivery position of the target substance; based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, deliver the target substance to the target position. In the above manner, by obtaining the corresponding relationship between the opening orientation, size, and ultrasonic frequency of the microbubble structure and the flow field direction, highly accurate control of fluid flow is achieved. Ensure the accurate transportation of drugs in the microchannel structure, and can quickly and intuitively adapt to the microenvironment. Using the second mapping relationship, the opening size of the microbubble structure is made to correspond one-to-one with the size sizes of different target substances, realizing the matching delivery of target substances of different sizes, so that it can be applicable to a variety of target substances of different sizes, improving the flexibility and applicability of the delivery, and thus improving the delivery effect of the target substance.

[0053] In one embodiment, step 400 above can specifically be executed as follows:

[0054] S401, based on the target size, obtain the target opening of the microbubble structure that matches the target size from the second mapping relationship;

[0055] S402. Determine the first delivery path of the target substance in the microchannel structure based on the target delivery location;

[0056] S403. Determine the first flow field direction of the fluid based on the first delivery path;

[0057] S404. Based on the first flow field direction and the target opening, obtain the first ultrasonic frequency matching the first flow field direction and the first orientation of the target bubble structure from the first mapping relationship, where the opening size of the target bubble structure is the target opening;

[0058] S405. Arrange the target bubble structure in the microchannel structure according to the first orientation, and apply ultrasonic waves with the first ultrasonic frequency to the target bubble structure to deliver the target substance to the target delivery location along the first delivery path.

[0059] Optionally, in a feasible implementation manner of this application, first use the second mapping relationship to match the size of the target substance with the opening size of the microbubble structure to determine the target opening of the microbubble structure required for the target substance. Subsequently, through experiments or simulations, determine the ideal delivery path of the target substance in the microchannel structure, that is, the first delivery path. Subsequently, according to the first delivery path, determine the flow direction of the fluid in the microchannel structure, that is, the first flow field direction. And use the first mapping relationship to match the first flow field direction and the target opening size to obtain the corresponding ultrasonic frequency and the orientation of the target bubble structure. Finally, according to the obtained first ultrasonic frequency and orientation, arrange the target bubble structure in the microchannel structure, and then by applying the corresponding ultrasonic waves, realize delivering the target substance to the target delivery location along the first delivery path. This process can adjust the movement of the target bubble structure by controlling the parameters of the ultrasonic waves, so as to achieve precise delivery of the target substance.

[0060] Optionally, in a specific implementation manner of this application, as Figure 2 shown, (a) is the flow field distribution driven by the ultrasonic frequency f1; (b) is the flow field distribution driven by the ultrasonic frequency f2. Multiple microbubble structures are arranged in the microstructured channel, where the microbubbles 1-1, 1-2, etc. have different opening sizes, and the microbubbles with different opening sizes have different orientations in the microstructured channel. A flow field consistent with the orientation of the microbubble 1-1 is generated in the channel under the drive of the ultrasonic frequency f1, as Figure 2 (a) shown. A flow field consistent with the orientation of the microbubble 1-2 is generated under the drive of the ultrasonic frequency f2, as Figure 2 (b) shown.

[0061] As Figure 3As shown, the opening size is related to the microbubble vortex intensity and shows a correlation with the ultrasonic excitation frequency. The ultrasonic delivery method can deliver different materials and micro / nano payloads of different sizes, such as magnetic and non-magnetic, and even deliver living cells, micro / nano robots, etc., and can achieve long-distance delivery. As Figure 4 shown, for micro / nano payloads of different sizes, larger particles are more difficult to escape the confinement of the vortex, and smaller particles can escape from the vortex, thus realizing the screening of particles of different particle sizes (i.e., constructing the second mapping relationship).

[0062] In these alternative embodiments, by obtaining the corresponding microbubble structure and ultrasonic parameters according to the size and delivery position of the target substance, precise delivery of the target substance is achieved. This helps to improve the delivery efficiency of therapeutic drugs, living cells, etc. at the microscale. By determining the first delivery path, the flow path of the target substance in the microchannel structure can be flexibly controlled to reach the target delivery position in a set direction. This helps to avoid complex vascular structures and improve the delivery accuracy.

[0063] Using ultrasonic waves as the driving means, which has the characteristics of high frequency, high intensity, and strong controllability, helps the microbubble structure to generate a fine flow field effect in the microchannel, thereby promoting the net flow of the target substance. Such an ultrasonic driving method has greater portability and applicability compared with the traditional magnetic field driving. By dynamically adjusting the ultrasonic frequency and the arrangement of the bubble structure, real-time monitoring and control of the delivery process can be achieved, ensuring the immediacy and flexibility of the delivery effect. Generally speaking, the present application can improve the delivery accuracy, speed, and controllability of the target substance at the microscale, providing new possibilities for treating diseases such as cancer and having important medical and clinical application prospects.

[0064] In one embodiment, the microbubble structure includes a plurality of first sub-bubbles, and the microchannel includes a plurality of first sub-channels; the above step 400 can specifically further perform the following steps:

[0065] S406, based on the target size, obtain the first size range that matches the target size from the second mapping relationship;

[0066] S407, based on the target delivery position, determine the second delivery path of the target substance in each first sub-channel;

[0067] S408, for any one of the multiple first sub-channels to be transported, based on the second delivery path corresponding to the to-be-transported channel, determine the second flow field direction of the fluid in the to-be-transported channel;

[0068] S409. Based on the second flow field direction and the first size range, obtain from the first mapping relationship the second ultrasonic frequency that matches the second flow field direction, and the second orientations corresponding to multiple first target sub-bubbles, where the multiple first sub-bubbles include the multiple first target sub-bubbles, and the opening size of each first target sub-bubble is within the first size range;

[0069] S410. Arrange each first target sub-bubble in the channel to be transported according to the second orientation corresponding to each first target sub-bubble, and apply ultrasonic waves with the second ultrasonic frequency to each first target sub-bubble, so that the target substance flows in the channel to be transported along the second delivery path.

[0070] Optionally, in a feasible implementation manner of the present application, the size of the target microbubble structure can be obtained first through a microscope, an imaging device, or an image processing method. And find the first size range that matches the target size in the second mapping relationship. Subsequently, use hydrodynamic simulation or experimental data to determine the movement path of the target substance in each first sub-channel. And combine the target delivery position and the channel geometric characteristics to determine the second delivery path of the target substance in each first sub-channel. For each channel to be transported, based on its corresponding second delivery path, determine the second flow field direction of the fluid in the channel. Subsequently, according to the first mapping relationship, find the second ultrasonic frequency and the second orientation that match the second flow field direction and the first size range.

[0071] Optionally, in the embodiments of the present application, as Figure 5 shown, by setting multiple groups of different-sized bubble combinations, 4-1, 4-2, 4-3, and 4-4 represent microbubbles with different openings. Under the drive and control of ultrasonic signals with different frequencies, the controllable movement of the microstructures on the plane can be achieved.

[0072] In these optional embodiments, based on the target size and the delivery position, the size range of the microbubble structure and the delivery path of the target substance in each channel are determined. This enables precise control and regulation of the target substance at the microscale. Through the parameter matching of the second delivery path, the flow field direction, the ultrasonic frequency, and the bubble structure, a flow field with a specific direction is generated in the channel to be transported. This helps to achieve the orderly and directional transportation of the fluid in the microfluidic environment. Arrange the bubbles in the channel to be transported according to the second orientation corresponding to each first target sub-bubble, and apply ultrasonic waves with the second ultrasonic frequency, which realizes the efficient energy transfer to the target substance. This can improve the delivery efficiency and reduce the additional impact on the target substance.

[0073] And since this application includes multiple first sub-channels and corresponding microbubble structures, parallel processing of multiple target substances can be achieved. Such a multi-channel design helps to improve the efficiency and speed of delivery. Generally speaking, this technical solution realizes the directional and precise delivery of target substances by acoustic means at the microscale, has strong controllability and applicability, is applicable to fields such as microfluidics and micro-nano payload delivery, and provides new ideas and solutions for the fine operation of microfluidic systems.

[0074] In one embodiment, the microbubble structure includes multiple bubble groups, each bubble group includes multiple second sub-bubbles, and the microchannel includes multiple second sub-channels; the above step 400 can specifically further perform the following steps:

[0075] S411, obtain a preset third mapping relationship, where the third mapping relationship includes the one-to-one correspondence between multiple bubble groups, multiple ultrasonic frequencies, and multiple flow field directions;

[0076] S412, based on the target delivery position and the arrangement positions of multiple second sub-channels, determine the shortest delivery path of the target substance in multiple second sub-channels. The shortest delivery path includes at least one target channel, and the target channel is the flow channel of the target substance. Multiple second sub-channels include at least one target channel;

[0077] S413, for any target sub-channel in at least one target channel, based on the sub-path corresponding to the target sub-channel, determine the third flow field direction of the target sub-channel;

[0078] S414, based on the third flow field direction, obtain the target bubble group and the third ultrasonic frequency that match the third flow field direction from the third mapping relationship;

[0079] S415, arrange the target bubble group in the target sub-channel and apply ultrasonic waves with the third ultrasonic frequency to the target bubble group, so that the target substance flows in the target sub-channel according to the sub-path.

[0080] Optionally, in a feasible implementation manner of this application, a series of experiments or simulations can be first carried out to determine the relationship between different bubble groups, ultrasonic frequencies, and flow field directions. By systematically testing different parameters, record the behavior of the bubble group under different ultrasonic frequencies and flow field directions. Subsequently, using a path planning algorithm, based on the delivery position of the target substance and the arrangement positions of multiple second sub-channels, calculate the shortest delivery path. The algorithm needs to consider the spatial layout of the channels and any physical obstacles. Subsequently, according to the preset mapping relationship, map the sub-path corresponding to the target sub-channel to the corresponding flow field direction. It may be necessary to establish a table or mapping function to map the sub-path to the numerical value of the flow field direction.

[0081] Finally, according to the third flow field direction, the target bubble group and the third ultrasonic frequency that match it can be obtained from the preset mapping relationship. Then, the obtained target bubble group is arranged in the target sub-channel, and ultrasonic waves with the third ultrasonic frequency are applied to these bubble groups through the ultrasonic system. This can be achieved through the precise control of the ultrasonic generator and the sensor.

[0082] Optionally, in a specific implementation manner of the present application, as Figure 6 shown, by arranging bubble groups 6-3 that can generate different flow directions in four different channels 6-4, 6-5, 6-6, and 6-7, the bubble group is composed of microbubbles 6-1 and 6-2 with different orientations. By driving with different ultrasonic frequencies, flows in any direction can be achieved in the microchannel.

[0083] In these optional embodiments, by designing the layout of the bubble group and the regulation of the ultrasonic frequency, flows in any direction can be achieved in the microchannel. This provides more flexible flow control for the microfluidic system to adapt to different actual needs. Microbubbles with different orientations can generate different flow directions. Combining with the control of the ultrasonic frequency, highly directional microfluidic flows can be achieved. This is very important for applications that require precise control at the microscale. By adjusting the ultrasonic frequency and the layout of the microbubble group, real-time, flexible, and adjustable adjustments of the fluid flow direction can be achieved to meet the needs of different experimental or application scenarios. Compared with other microfluidic control methods, this design may reduce the complexity of the system, making the experiment or application easier to implement and maintain. Generally speaking, this method of achieving flows in any direction through different ultrasonic frequencies and microbubble combinations brings more flexibility and adjustability to the field of microfluidic control, which helps to improve the efficiency and precision of the microfluidic system.

[0084] In one embodiment, the microbubble structure is enclosed by multiple surfaces;

[0085] At least one sub-bubble is arranged on each surface, and the opening sizes of the sub-bubbles located on the same surface are the same.

[0086] Optionally, in an embodiment of the present application, as Figure 5 shown, by setting multiple groups of bubble combinations with different sizes, 4-1, 4-2, 4-3, and 4-4 represent microbubbles with different openings. Under the drive and control of ultrasonic signals with different frequencies, the controllable movement of the micro-structure on the plane can be achieved.

[0087] In one embodiment, the microbubble structure includes multiple extension parts, and the multiple extension parts are circumferentially arranged on the main body part of the microbubble structure;

[0088] One sub-bubble is arranged on one extension part.

[0089] Optionally, in an embodiment of the present application, as Figure 7As shown, by arranging microbubbles 5-1 and 5-2 with different opening sizes in a circumference and applying ultrasonic excitation signals with different frequencies, the rotational motion of the microstructures can be achieved.

[0090] In these alternative embodiments, by using microbubbles with different opening sizes and excitation of ultrasonic frequencies, the rotational motion of the microstructures can be achieved. This provides an effective means for precise manipulation at the microscale. The application of the ultrasonic excitation signal is a non-contact manipulation method, which does not require direct contact with the microstructures, reduces the interference to the microstructures, and can achieve precise control at the microscale. By changing the arrangement and excitation parameters, various motion modes of the microstructures can be designed, expanding the possibilities of the motion of the microstructures in microfluidic and micromechanical systems.

[0091] Optionally, in the embodiments of the present application, three regulation methods are developed based on acoustic driving and controlling of microbubbles. The first is to generate asymmetric vortices through the interaction between the microbubbles and the boundary, induce streamline escape, and generate a net flow of the microfluid. The second is to achieve the controllable flow of the microfluid in the microchannel through ultrasonic frequency regulation. The third is to utilize the different ratios of the microchannel velocity to the microvortex velocity under the microfluids in different directions generated at different ultrasonic frequencies to achieve the screening and delivery of different microloads.

[0092] And the present application can be used for the rapid, large-scale, and controllable delivery of micro-nano loads in microchannels; it can also be used for the controllable transportation in the forward and reverse directions in the field of microfluidics; it can also be used for the screening of loads with different particle sizes in the microfluidic environment; it can also be used for delivering active substances such as cells and maintaining their activity; it can also be used for the controllable motion of microstructures in a low Reynolds number environment; it can also be used for achieving the controllable selection of different channels in the microchannel.

[0093] Figure 8 The structural schematic diagram of the microbubble control device provided by another embodiment of the present application is shown. For the sake of convenience of description, only the parts related to the embodiments of the present application are shown.

[0094] Refer to Figure 8 , the microbubble control device is applied to a microbubble structure. The microbubble structure is arranged in a microchannel structure, and the fluid flows in the microchannel structure. The microbubble structure is used to deliver the target substance. The microbubble control device may include:

[0095] A first acquisition module 801, configured to acquire a preset first mapping relationship, where the first mapping relationship includes the corresponding relationship between the opening orientations of a plurality of microbubble structures, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions. The flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure;

[0096] The second acquisition module 802 is configured to acquire a preset second mapping relationship, where the second mapping relationship includes a one-to-one correspondence between the opening sizes of multiple microbubble structures and the size of multiple target substances;

[0097] The third acquisition module 803 is configured to acquire the target size of the target substance and the target delivery position of the target substance;

[0098] The delivery module 804 is configured to deliver the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship.

[0099] In one embodiment, the delivery module 804 may include:

[0100] The first acquisition sub-module is configured to acquire a target opening of a microbubble structure that matches the target size from the second mapping relationship based on the target size;

[0101] The first determination sub-module is configured to determine a first delivery path of the target substance in the microchannel structure based on the target delivery position;

[0102] The second determination sub-module is configured to determine a first flow field direction of the fluid based on the first delivery path;

[0103] The second acquisition sub-module is configured to acquire a first ultrasonic frequency that matches the first flow field direction and a first orientation of the target bubble structure from the first mapping relationship based on the first flow field direction and the target opening, where the opening size of the target bubble structure is the target opening;

[0104] The first arrangement sub-module is configured to arrange the target bubble structure in the microchannel structure according to the first orientation and apply ultrasonic waves with the first ultrasonic frequency to the target bubble structure to deliver the target substance to the target delivery position according to the first delivery path.

[0105] In one embodiment, the microbubble structure includes a plurality of first sub-bubbles, and the microchannel includes a plurality of first sub-channels; the delivery module 804 may further include:

[0106] The third acquisition sub-module is configured to acquire a first size range that matches the target size from the second mapping relationship based on the target size;

[0107] The third determination sub-module is configured to determine a second delivery path of the target substance in each first sub-channel based on the target delivery position;

[0108] The fourth determination sub-module is configured to, for any one of the plurality of first sub-channels to be transported, determine a second flow field direction of the fluid in the to-be-transported channel based on the second delivery path corresponding to the to-be-transported channel;

[0109] A fourth acquisition sub-module, configured to obtain, based on the second flow field direction and the first size range, a second ultrasonic frequency that matches the second flow field direction from the first mapping relationship, and a second orientation corresponding to a plurality of first target sub-bubbles, the plurality of first sub-bubbles including the plurality of first target sub-bubbles, and the opening size of each first target sub-bubble being within the first size range;

[0110] A second arrangement sub-module, configured to arrange each first target sub-bubble in the channel to be transported according to the second orientation corresponding to each first target sub-bubble, and apply ultrasonic waves with the second ultrasonic frequency to each first target sub-bubble, so that the target substance flows in the channel to be transported along the second delivery path.

[0111] In one embodiment, the micro-bubble structure includes a plurality of bubble groups, each bubble group includes a plurality of second sub-bubbles, and the micro-channel includes a plurality of second sub-channels; the delivery module 804 may further include:

[0112] A fifth acquisition sub-module, configured to obtain a preset third mapping relationship, where the third mapping relationship includes a one-to-one correspondence between a plurality of bubble groups, a plurality of ultrasonic frequencies, and a plurality of flow field directions;

[0113] A fifth determination sub-module, configured to determine, based on the target delivery position and the arrangement positions of the plurality of second sub-channels, a shortest delivery path of the target substance in the plurality of second sub-channels, the shortest delivery path including at least one target channel, the target channel being a flow channel of the target substance, and the plurality of second sub-channels including at least one target channel;

[0114] A sixth determination sub-module, configured to, for any target sub-channel in at least one target channel, determine a third flow field direction of the target sub-channel based on the sub-path corresponding to the target sub-channel;

[0115] A sixth acquisition sub-module, configured to obtain, based on the third flow field direction, a target bubble group that matches the third flow field direction and a third ultrasonic frequency from the third mapping relationship;

[0116] A third arrangement sub-module, configured to arrange the target bubble group in the target sub-channel and apply ultrasonic waves with the third ultrasonic frequency to the target bubble group, so that the target substance flows in the target sub-channel along the sub-path.

[0117] In one embodiment, the micro-bubble structure is enclosed by a plurality of surfaces;

[0118] At least one sub-bubble is arranged on each surface, and the opening sizes of the sub-bubbles located on the same surface are the same.

[0119] In one embodiment, the micro-bubble structure includes a plurality of extensions, and the plurality of extensions are circumferentially arranged on the main body of the micro-bubble structure;

[0120] A sub-bubble is provided in an extension part.

[0121] It should be noted that the information interaction, execution process, etc. between the above-mentioned devices / modules are based on the same concept as the method embodiments of this application, and are devices corresponding to the above-mentioned battery thermal runaway warning method. All implementation manners in the above method embodiments are applicable to the embodiments of this device. For its specific functions and the technical effects brought, please refer to the method embodiment part for details, and will not be elaborated here.

[0122] Those skilled in the art can clearly understand that, for the convenience and conciseness of description, only the above-mentioned division of each functional unit / module is used as an example for illustration. In actual applications, the above-mentioned functions can be allocated to different functional units / modules according to needs, that is, the internal structure of the device can be divided into different functional units or modules to complete all or part of the functions described above. Each functional unit / module in the embodiment can be integrated into a processing unit, or each unit can exist physically alone, or two or more units can be integrated into one unit. The above-mentioned integrated unit can be implemented in the form of hardware or in the form of a software functional unit. In addition, the specific names of each functional unit / module are only for the convenience of mutual distinction and do not limit the protection scope of this application. The specific working process of the units / modules in the above system can refer to the corresponding process in the foregoing method embodiments and will not be elaborated here.

[0123] Figure 9 The schematic hardware structure diagram of the electronic device provided by the embodiment of this application is shown.

[0124] The device may include a processor 901 and a memory 902 storing program instructions.

[0125] When the processor 901 executes the program, it implements the steps in any of the above method embodiments.

[0126] Exemplarily, the program can be divided into one or more modules / units, and one or more modules / units are stored in the memory 902 and executed by the processor 901 to complete this application. One or more modules / units can be a series of program instruction segments capable of completing specific functions, and the instruction segments are used to describe the execution process of the program in the device.

[0127] Specifically, the above-mentioned processor 901 may include a central processing unit (CPU), or an application specific integrated circuit (ASIC), or one or more integrated circuits configured to implement the embodiments of this application.

[0128] The memory 902 may include a mass storage for data or instructions. By way of example and not limitation, the memory 902 may include a hard disk drive (HDD), a floppy disk drive, flash memory, an optical disc, a magneto-optical disc, magnetic tape, or a universal serial bus (USB) drive, or a combination of two or more of these. In a suitable case, the memory 902 may include removable or non-removable (or fixed) media. In a suitable case, the memory 902 may be inside or outside of the integrated gateway disaster recovery device. In a specific embodiment, the memory 902 is a non-volatile solid-state memory.

[0129] The memory may include a read-only memory (ROM), a random access memory (RAM), a magnetic disk storage media device, an optical storage media device, a flash memory device, an electrical, optical, or other physical / tangible memory storage device. Thus, generally, the memory includes one or more tangible (non-transitory) readable storage media (e.g., memory devices) encoded with software including computer-executable instructions, and when the software is executed (e.g., by one or more processors), it is operable to perform the operations described with reference to the method according to one aspect of the present disclosure.

[0130] The processor 901 reads and executes the program instructions stored in the memory 902 to implement any one of the methods in the above embodiments.

[0131] In one example, the electronic device may further include a communication interface 903 and a bus 910. Among them, the processor 901, the memory 902, and the communication interface 903 are connected through the bus 910 to complete communication with each other.

[0132] The communication interface 903 is mainly used to implement communication between the various modules, devices, units, and / or devices in the embodiments of the present application.

[0133] The bus 910 includes hardware, software, or both, and couples the components of the online data flow metering device to each other. By way of example and not limitation, the bus may include an Accelerated Graphics Port (AGP) or other graphics bus, an Extended Industry Standard Architecture (EISA) bus, a Front Side Bus (FSB), a HyperTransport (HT) interconnect, an Industry Standard Architecture (ISA) bus, an InfiniBand interconnect, a Low Pin Count (LPC) bus, a memory bus, a MicroChannel Architecture (MCA) bus, a Peripheral Component Interconnect (PCI) bus, a PCI-Express (PCI-X) bus, a Serial Advanced Technology Attachment (SATA) bus, a Video Electronics Standards Association Local (VLB) bus, or other suitable bus or a combination of two or more of these. Where appropriate, the bus 910 may include one or more buses. Although the embodiments of the present application describe and illustrate specific buses, the present application contemplates any suitable bus or interconnect.

[0134] In addition, in combination with the methods in the above embodiments, the embodiments of the present application may be implemented by providing a storage medium. Program instructions are stored on the storage medium; when the program instructions are executed by a processor, any one of the methods in the above embodiments is implemented.

[0135] The embodiments of the present application further provide a chip, which includes a processor and a communication interface. The communication interface is coupled to the processor. The processor is used to run programs or instructions to implement each process of the above method embodiments, and can achieve the same technical effects. To avoid repetition, it will not be described in detail here.

[0136] It should be understood that the chip mentioned in the embodiments of the present application may also be referred to as a system-on-chip, system chip, chip system, or system-on-chip, etc.

[0137] The embodiments of the present application provide a computer program product, which is stored in a storage medium. The program product is executed by at least one processor to implement each process of the above method embodiments, and can achieve the same technical effects. To avoid repetition, it will not be described in detail here.

[0138] It should be clear that the present application is not limited to the specific configurations and processes described above and shown in the figures. For the sake of brevity, the detailed description of known methods is omitted here. In the above embodiments, several specific steps are described and illustrated as examples. However, the method process of the present application is not limited to the specific steps described and shown. Those skilled in the art can make various changes, modifications, and additions, or change the order between steps after understanding the spirit of the present application.

[0139] The functional modules shown in the above structural block diagram can be implemented as hardware, software, firmware, or a combination thereof. When implemented in hardware, it can be, for example, an electronic circuit, an application specific integrated circuit (ASIC), appropriate firmware, a plug-in, a functional card, and so on. When implemented in software, the elements of the present application are programs or code segments for performing the required tasks. The program or code segment can be stored in a machine-readable medium, or transmitted over a transmission medium or communication link via a data signal carried in a carrier wave. A "machine-readable medium" can include any medium capable of storing or transmitting information. Examples of machine-readable media include electronic circuits, semiconductor memory devices, ROM, flash memory, erasable ROM (EROM), floppy disks, CD-ROMs, optical discs, hard disks, fiber optic media, radio frequency (RF) links, and so on. The code segment can be downloaded via a computer network such as the Internet, an intranet, and so on.

[0140] It should also be noted that in the exemplary embodiments mentioned in the present application, some methods or systems are described based on a series of steps or devices. However, the present application is not limited to the order of the above steps, that is, the steps can be executed in the order mentioned in the embodiments, or different from the order in the embodiments, or several steps can be executed simultaneously.

[0141] As described above with reference to the flowcharts and / or block diagrams of methods, apparatuses (systems), and program products according to embodiments of the present disclosure. It should be understood that each block in the flowchart and / or block diagram, and the combinations of blocks in the flowchart and / or block diagram, can be implemented by computer program instructions. These program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing device to produce a machine such that the instructions executed by the processor of the computer or other programmable data processing device enable the implementation of the functions / actions specified in one or more blocks of the flowchart and / or block diagram. Such a processor can be, but is not limited to, a general-purpose processor, a special-purpose processor, a special application processor, or a field programmable logic circuit. It is also understood that each block in the block diagram and / or flowchart, and the combinations of blocks in the block diagram and / or flowchart, can also be implemented by dedicated hardware for performing the specified functions or actions, or by a combination of dedicated hardware and computer instructions.

[0142] The above is only the specific implementation manner of the present application. Those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working processes of the systems, modules, and units described above can refer to the corresponding processes in the foregoing method embodiments and will not be elaborated herein. It should be understood that the protection scope of the present application is not limited thereto. Any person skilled in the art within the technical scope disclosed in the present application can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present application.

Claims

1. A microbubble control method, characterized in that, Applied to a microbubble structure, the microbubble structure is disposed in a microchannel structure, fluid flows in the microchannel structure, and the microbubble structure is used to deliver a target substance. The method includes: Obtaining a preset first mapping relationship, the first mapping relationship including the corresponding relationship between the opening orientations of a plurality of the microbubble structures, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions, where the flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the microbubble structure; Obtaining a preset second mapping relationship, the second mapping relationship including the one-to-one correspondence between a plurality of the opening sizes of the microbubble structures and a plurality of the size sizes of the target substances; Obtaining the target size of the target substance and the target delivery position of the target substance; Based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, delivering the target substance to the target delivery position.

2. The method according to claim 1, wherein The delivering the target substance to the target delivery position based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship includes: Based on the target size, obtaining the target opening of the microbubble structure that matches the target size from the second mapping relationship; Based on the target delivery position, determining the first delivery path of the target substance in the microchannel structure; Based on the first delivery path, determining the first flow field direction of the fluid; Based on the first flow field direction and the target opening, obtaining the first ultrasonic frequency that matches the first flow field direction and the first orientation of the target bubble structure from the first mapping relationship, where the opening size of the target bubble structure is the target opening; Arranging the target bubble structure in the microchannel structure according to the first orientation and applying ultrasonic waves with the first ultrasonic frequency to the target bubble structure to deliver the target substance to the target delivery position according to the first delivery path.

3. The method according to claim 1, wherein The microbubble structure includes a plurality of first sub-bubbles, and the microchannel includes a plurality of first sub-channels; The delivering the target substance to the target delivery position based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship further includes: Based on the target size, obtaining the first size range that matches the target size from the second mapping relationship; Based on the target delivery position, determining the second delivery path of the target substance in each first sub-channel; For any one of the plurality of first sub-channels to be transported, based on the second delivery path corresponding to the sub-channel to be transported, determining the second flow field direction of the fluid in the sub-channel to be transported; Based on the second flow field direction and the first size range, obtain from the first mapping relationship a second ultrasonic frequency that matches the second flow field direction, and a second orientation corresponding to a plurality of first target sub-bubbles, where the plurality of first sub-bubbles includes the plurality of first target sub-bubbles, and the opening size of each first target sub-bubble is within the first size range; Arrange each first target sub-bubble in the channel to be transported according to the second orientation corresponding to each first target sub-bubble, and apply ultrasonic waves with the second ultrasonic frequency to each first target sub-bubble, so that the target substance flows in the channel to be transported along the second delivery path.

4. The method according to claim 1, characterized in that The micro-bubble structure includes a plurality of bubble groups, each bubble group includes a plurality of second sub-bubbles, and the micro-channel includes a plurality of second sub-channels; Based on the first matching relationship between the target delivery position and the first mapping relationship, and the second matching relationship between the target size and the second mapping relationship, delivering the target substance to the target delivery position further includes: Obtain a preset third mapping relationship, where the third mapping relationship includes a one-to-one correspondence between the plurality of bubble groups, a plurality of ultrasonic frequencies, and a plurality of flow field directions; Based on the target delivery position and the arrangement positions of the plurality of second sub-channels, determine the shortest delivery path of the target substance in the plurality of second sub-channels, where the shortest delivery path includes at least one target channel, the target channel is the flow channel of the target substance, and the plurality of second sub-channels includes the at least one target channel; For any target sub-channel in the at least one target channel, determine the third flow field direction of the target sub-channel based on the sub-path corresponding to the target sub-channel; Based on the third flow field direction, obtain from the third mapping relationship a target bubble group that matches the third flow field direction, and a third ultrasonic frequency; Arrange the target bubble group in the target sub-channel, and apply ultrasonic waves with the third ultrasonic frequency to the target bubble group, so that the target substance flows in the target sub-channel along the sub-path.

5. The method according to claim 3, characterized in that, The micro-bubble structure is enclosed by a plurality of surfaces; At least one of the sub-bubbles is arranged on each surface, and the opening sizes of the sub-bubbles located on the same surface are the same.

6. The method according to claim 3, characterized in that, The micro-bubble structure includes a plurality of extensions, and the plurality of extensions are circumferentially arranged on the main body of the micro-bubble structure; One sub-bubble is arranged on one extension.

7. A microbubble control device, characterized in that, Applied to a micro-bubble structure, the micro-bubble structure is arranged in a micro-channel structure, fluid flows in the micro-channel structure, and the micro-bubble structure is used to deliver a target substance. The device includes: A first acquisition module, configured to acquire a preset first mapping relationship, where the first mapping relationship includes a correspondence between a plurality of opening orientations of the micro-bubble structure, a plurality of opening sizes, a plurality of ultrasonic frequencies, and a plurality of flow field directions, the flow field direction is the flow direction of the fluid, and the ultrasonic frequency is the frequency of the ultrasonic wave applied to the micro-bubble structure; A second acquisition module, configured to acquire a preset second mapping relationship, where the second mapping relationship includes a one-to-one correspondence between the opening sizes of a plurality of the microbubble structures and the size of a plurality of target substances; A third acquisition module, configured to acquire the target size of the target substance and the target delivery position of the target substance; A delivery module, configured to deliver the target substance to the target delivery position based on a first matching relationship between the target delivery position and the first mapping relationship and a second matching relationship between the target size and the second mapping relationship.

8. An electronic device, characterized in that, The device includes: a processor and a memory storing computer program instructions; When the processor executes the computer program instructions, the microbubble control method according to any one of claims 1-6 is implemented.

9. A computer-readable storage medium, characterized in that, Computer program instructions are stored on the computer-readable storage medium, and when the computer program instructions are executed by a processor, the microbubble control method according to any one of claims 1-6 is implemented.

10. A computer program product, characterized in that, When the instructions in the computer program product are executed by the processor of the electronic device, the electronic device is caused to execute the microbubble control method according to any one of claims 1-6.

Images