Anticorrosive composition containing piroctone olamine salt

Abstract

The invention relates to the technical field of compounding of piroctone olamine salts, and particularly discloses an anti-corrosion composition containing piroctone olamine salts. The invention relates to an anti-corrosion composition containing piroctone olamine salt. The anti-corrosion composition is prepared from the following raw materials in parts by weight: 0.5 to 1.5 parts of piroctone olamine salt, 30 to 40 parts of propylene glycol, 5 to 10 parts of pentanediol, 3 to 7 parts of folium ginkgo extract, 10 to 15 parts of nano zinc ricinoleate and 4 to 6 parts of sodium lauroyl sarcosinate. According to the present invention, the maximum antibacterial rates of the obtained preservative composition containing the piroctone olamine salt on malassezia furfur ATCC44344 at 5 min, 10 min and 30 min are respectively 74.2%, 95.3% and 99.9%, such that the antibacterial property of the preservative composition containing the piroctone olamine salt is improved.

Description

Technical Field

[0001] The present application relates to the field of compounding of piroctone olamine, and more specifically, to an anti-corrosion composition containing piroctone olamine. Background Art

[0002] Piroctone olamine is a broad-spectrum antibacterial agent. It mainly inhibits substrate transport such as the transport of leucine, resulting in changes in the cell membrane, and ultimately leading to cell rupture, achieving the effect of antibacterial and bactericidal, so as to achieve the purpose of anti-corrosion, and is widely used in the fields of personal care products and anti-dandruff shampoos. However, piroctone olamine has factors such as photo-instability and poor water solubility. Although it has low irritation to the skin and eyes, its antibacterial effect is weak.

[0003] In the related art, in order to ensure the dispersion stability of piroctone olamine in the anti-corrosion composition system, propylene glycol is selected as a solvent to solve the problem of poor water solubility, and then oxybenzone is added to improve the photo-instability of piroctone olamine, so as to improve the antibacterial agent of the anti-corrosion composition, but the improvement effect is not obvious. Summary of the Invention

[0004] In order to further improve the antibacterial property of piroctone olamine, the present application provides an anti-corrosion composition containing piroctone olamine.

[0005] In the first aspect, the present application provides an anti-corrosion composition containing piroctone olamine, and it adopts the following technical solution: An anti-corrosion composition containing piroctone olamine, which comprises the following raw materials in parts by weight: 0.5 - 1.5 parts of piroctone olamine, 30 - 40 parts of propylene glycol, 5 - 10 parts of pentylene glycol, 3 - 7 parts of ginkgo leaf extract, 10 - 15 parts of nano zinc ricinoleate, and 4 - 6 parts of sodium lauroyl sarcosinate.

[0006] For the anti-corrosion composition containing piroctone olamine of the present application, the raw materials are selected as 0.5 - 1.5 parts of piroctone olamine, 30 - 40 parts of propylene glycol, 5 - 10 parts of pentylene glycol, 3 - 7 parts of ginkgo leaf extract, 10 - 15 parts of nano zinc ricinoleate, and 4 - 6 parts of sodium lauroyl sarcosinate. Any value within their respective ranges can be selected, and all can, to varying degrees, improve the antibacterial property of the anti-corrosion composition containing piroctone olamine.

[0007] By adopting the above technical solution, adding propylene glycol can, on the one hand, dissolve piroctone olamine, and on the other hand, can damage the microbial cell membrane, improving the solubility and permeability of piroctone olamine, thereby improving the antibacterial property of piroctone olamine.

[0008] Pentanediol has a certain antibacterial effect. It can damage cell membranes and interfere with the microbial enzyme system, while piroctone olamine inhibits microbial energy metabolism and has a long-acting antibacterial effect. When the two are combined, pentanediol can increase the penetration rate of piroctone olamine through the stratum corneum and enhance follicle targeting, thereby improving the antibacterial property of the preservative composition and shortening the bactericidal time of piroctone olamine. In addition, pentanediol has a certain antioxidant capacity, which can reduce the photodegradation of piroctone and improve the photo-instability of piroctone olamine, thus ensuring the quality of piroctone olamine.

[0009] Zinc ricinoleate nanoparticles have a relatively high antibacterial contact efficiency. It can reduce sebum secretion, weaken the survival environment of fungi, and also has a certain antioxidant capacity. It can slow down the photodegradation of piroctone olamine, improve the photo-instability of piroctone olamine, reduce the dosage of piroctone olamine, and also relieve the dryness caused by piroctone olamine. Therefore, zinc ricinoleate can improve the antibacterial property of the preservative composition containing piroctone olamine.

[0010] Adding ginkgo biloba extract can, on the one hand, reduce the dosage of piroctone olamine. On the other hand, the terpene lactones in ginkgo biloba extract can open the stratum corneum barrier of piroctone olamine and increase the follicle penetration rate of piroctone olamine. When it is combined with pentanediol, pentanediol can promote the penetration of ginkgo biloba extract through the microbial cell membrane and improve the antibacterial property of ginkgo biloba extract. The two have a synergistic antibacterial effect.

[0011] Sodium lauroyl sarcosinate is a relatively mild surfactant based on biological substances. It has biodegradability, antibacterial property and good compatibility, and has good foaming and cleaning ability. It can improve the dispersibility of raw materials such as piroctone olamine, pentanediol, and zinc ricinoleate nanoparticles in the preservative composition and improve the antibacterial property of the preservative composition.

[0012] As a preference: A preservative composition containing piroctone olamine comprises the following raw materials in parts by weight: 0.8 - 1.2 parts of piroctone olamine, 34 - 36 parts of propylene glycol, 7 - 9 parts of pentanediol, 4 - 6 parts of ginkgo biloba extract, 12 - 14 parts of zinc ricinoleate nanoparticles, and 4.5 - 5.5 parts of sodium lauroyl sarcosinate.

[0013] This application's preservative composition containing piroctone olamine selects 0.8 - 1.2 parts of piroctone olamine, 34 - 36 parts of propylene glycol, 7 - 9 parts of pentanediol, 4 - 6 parts of ginkgo biloba extract, 12 - 14 parts of zinc ricinoleate nanoparticles, and 4.5 - 5.5 parts of sodium lauroyl sarcosinate. Any value within their respective ranges can be selected, and it can improve the antibacterial property of the preservative composition containing piroctone olamine.

[0014] As a preference: The weight part ratio of the ginkgo biloba extract to pentanediol is 1:(1 - 2).

[0015] By adopting the above - mentioned scheme and adjusting the weight - part ratio of ginkgo leaf extract to pentylene glycol, the follicular penetration rate of piroctone olamine can be further improved, thereby enhancing the antibacterial property of piroctone olamine and improving the antibacterial effect of the compound preservative.

[0016] Preferably: The nano - zinc ricinoleate is prepared by coating modification, specifically: Preparing the wall material: Adding chitosan and glyceryl tripalmitate to water and stirring to dissolve to obtain the wall material; Coating: Adding nano - zinc ricinoleate to the wall material and spray - drying to obtain modified nano - zinc ricinoleate; The mass ratio of the nano - zinc ricinoleate to the volume of the wall material is 1:(4 - 5); the ratio of the sum of the masses of chitosan and glyceryl tripalmitate to the volume of water is 1:(90 - 100).

[0017] By adopting the above - mentioned scheme, using chitosan and glyceryl tripalmitate as the composite wall material, chitosan provides a flexible framework and bio - adhesiveness, but has low mechanical strength. Glyceryl tripalmitate has the functions of enhancing compressive resistance and physical barrier. The combination of the two can reduce the rupture of the wall material coated on the surface of nano - zinc ricinoleate. Moreover, chitosan can inhibit bacterial growth and protect nano - zinc ricinoleate from microbial degradation, and glyceryl tripalmitate blocks moisture and oxygen, slowing down the oxidation or hydrolysis reaction of nano - zinc ricinoleate to ensure the antibacterial effect of nano - zinc ricinoleate.

[0018] In addition, glyceryl tripalmitate as the wall material can be degraded by lipase in areas with strong sebum secretion, enhancing the release rate of nano - zinc ricinoleate.

[0019] Preferably: The mass ratio of chitosan to glyceryl tripalmitate is 1:(1 - 1.5).

[0020] By adopting the above - mentioned technical scheme, excessive use of chitosan may lead to too strong hydrophilicity, too fast release and short antibacterial time of the modified nano - zinc ricinoleate. Adjusting the mass ratio of glyceryl tripalmitate to chitosan can further improve the stability of the modified nano - zinc ricinoleate, thereby further enhancing the antibacterial property of the modified nano - zinc ricinoleate.

[0021] Preferably: The preservative composition containing piroctone olamine further includes the following raw materials in parts by weight: 0.5 - 1 part of sodium cocoamphoacetate.

[0022] By adopting the above - mentioned technical scheme, sodium cocoamphoacetate can prevent the precipitation of sodium lauroyl sarcosinate, thereby further improving the dispersibility of raw materials such as piroctone olamine, pentylene glycol, and nano - zinc ricinoleate in the preservative composition, and thus enhancing the antibacterial property of the preservative composition.

[0023] Preferably, the weight ratio of sodium lauroyl sarcosinate to sodium cocoamphoacetate is 1:(3 - 7).

[0024] By adopting the above technical solution, adjusting the weight ratio of sodium lauroyl sarcosinate to sodium cocoamphoacetate further improves the dispersibility of raw materials such as piroctone olamine, pentylene glycol, and zinc ricinoleate in the anti-corrosion composition, thereby enhancing the antibacterial property of the anti-corrosion composition.

[0025] In a second aspect, the present application provides a preparation method for the above-mentioned anti-corrosion composition containing piroctone olamine, which is specifically achieved through the following technical solution: A preparation method for an anti-corrosion composition containing piroctone olamine, which includes the following operating steps: Mix piroctone olamine with propylene glycol, stir and dissolve, add it to sodium lauroyl sarcosinate for further mixing, and then sequentially add other raw materials to obtain the anti-corrosion composition containing piroctone olamine.

[0026] In summary, the present application includes at least one of the following beneficial technical effects: (1) By controlling the types and dosages of raw materials of the anti-corrosion composition containing piroctone olamine, the present application enables the anti-corrosion composition containing piroctone olamine to have antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min of 70.1 - 70.3%, 91.2 - 92.3%, and 99.1 - 99.4% respectively, improving the antibacterial property of the anti-corrosion composition.

[0027] (2) By modifying zinc ricinoleate nanoparticles and adjusting the mass ratio of chitosan to tripalmitin to 1:(1 - 1.5), the present application enables the anti-corrosion composition containing piroctone olamine to have antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min of 71.5 - 72.1%, 93.5 - 94.0%, and 99.6 - 99.7% respectively, further improving the antibacterial property of the anti-corrosion composition.

[0028] (3) By adding sodium cocoamphoacetate to the raw materials of the anti-corrosion composition containing piroctone olamine and controlling the weight ratio of sodium lauroyl sarcosinate to sodium cocoamphoacetate, the present application enables the anti-corrosion composition containing piroctone olamine to have antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min of 73.8 - 74.2%, 95.0 - 95.3%, and 99.9% respectively, further improving the antibacterial property of the anti-corrosion composition. Specific Embodiments

[0029] The present application will be further described in detail below in conjunction with specific embodiments. The following raw materials in the present application are all commercially available products. To make the raw materials of the present application fully disclosed, it should not be construed as a limitation on the source of the raw materials. Specifically: piroctone olamine, the content of the active substance is 99%; propylene glycol, model 2022; pentylene glycol, the content of the active substance is 95%; ginkgo biloba extract, flavonoids 24% and lactones 6%; nano zinc ricinoleate, the particle size is 50 nm; sodium lauroyl sarcosinate, the content of the active substance is 99%; chitosan, the content of the active substance is 99%; tripalmitin, the content of the active substance is 99%; sodium cocoamphoacetate, the content of the active substance is 99%.

[0030] The following is a preparation example of modified nano zinc ricinoleate: Preparation Example 1 The modified nano zinc ricinoleate of Preparation Example 1 was obtained through the following operation steps: Preparation of wall material: 1 kg of chitosan and 0.5 kg of tripalmitin were added to 200 L of water, stirred and dissolved to obtain the wall material; Coating: 1 kg of nano zinc ricinoleate was added to 5 L of the wall material, and spray-dried to obtain modified nano zinc ricinoleate.

[0031] Preparation Examples 2-5 The preparation method of the modified nano chitosan quaternary ammonium salt in Preparation Examples 2-5 is the same as that of Preparation Example 1 and the types of raw materials, except that the amounts of chitosan and tripalmitin are 750 g and 750 g, 680 g and 820 g, 600 g and 900 g, 500 g and 1000 g respectively, and the dosages of the remaining raw materials are the same as those in Preparation Example 1.

[0032] Example 1 The anti-corrosion composition containing piroctone olamine in Example 1 was prepared through the following operation steps: According to the dosages in Table 1, piroctone olamine was mixed with propylene glycol, stirred and dissolved, added to sodium lauroyl sarcosinate for further mixing, and other raw materials were added in sequence to obtain the anti-corrosion composition containing piroctone olamine.

[0033] Examples 2-5 The anti-corrosion compositions containing piroctone olamine in Examples 2-5 are exactly the same as those in Example 1 in terms of preparation method and types of raw materials, except that the dosages of ginkgo biloba extract and pentylene glycol are different. For details, see Table 1.

[0034] Table 1 Dosages of each raw material in the anti-corrosion compositions containing piroctone olamine in Examples 1-5 (kg) Example 1 Example 2 Example 3 Example 4 Example 5 Piroctone olamine 1 1 1 1 1 Propylene glycol 35 35 35 35 35 Pentylene glycol 5.4 5 6 8 7.5 Ginkgo biloba extract 6 5 4 4 3 Zinc ricinoleate nanometer 13 13 13 13 13 Sodium lauroyl sarcosinate 5 5 5 5 5 Examples 6-10 The anti-corrosion compositions containing piroctone olamine salt in Examples 6 - 10 have the same preparation method and types and dosages of raw materials as those in Example 3, except that the modified nano-zinc ricinoleate prepared in Preparation Examples 1 - 5 is respectively selected, and the dosages of the remaining raw materials are the same as those in Example 1.

[0035] Examples 11 - 15 The anti-corrosion compositions containing piroctone olamine salt in Examples 11 - 15 have the same preparation method and types and dosages of raw materials as those in Example 8, except that sodium cocoamphoacetate is respectively further added to the composite antibacterial agent raw materials, and the details are shown in Table 2.

[0036] Table 2 Dosages of each raw material of the anti-corrosion composition containing piroctone olamine salt in Examples 11 - 15 (kg) Example 11 Example 12 Example 13 Example 14 Example 15 Piroctone olamine 1 1 1 1 1 Propylene glycol 35 35 35 35 35 Pentylene glycol 6 6 6 6 6 Ginkgo biloba extract 4 4 4 4 4 Zinc ricinoleate nanometer 13 13 13 13 13 Sodium lauroyl sarcosinate 5 5 5 5 5 Sodium cocoamphoacetate 1 0.83 0.71 0.55 0.5 Comparative Example 1 The anti-corrosion composition containing piroctone olamine salt in Comparative Example 1 has the same preparation method as that in Example 1, except that the ginkgo leaf extract in the anti-corrosion composition raw materials is replaced with pentylene glycol in equal amount, and the remaining raw materials and dosages are the same as those in Example 1.

[0037] Comparative Example 2 The anti-corrosion composition containing piroctone olamine salt in Comparative Example 2 has the same preparation method as that in Example 1, except that the pentylene glycol in the anti-corrosion composition raw materials is replaced with ginkgo leaf extract in equal amount, and the remaining raw materials and dosages are the same as those in Example 1.

[0038] Comparative Example 3 The anti-corrosion composition containing piroctone olamine salt in Comparative Example 3 has the same preparation method as that in Example 1, except that nano-zinc ricinoleate is not added to the anti-corrosion composition raw materials, and the remaining raw materials and dosages are the same as those in Example 1.

[0039] Comparative Example 4 The anti-corrosion composition containing piroctone olamine salt in Comparative Example 4 has the same preparation method as that in Example 1, except that sodium lauroyl sarcosinate is not added to the anti-corrosion composition raw materials, and the remaining raw materials and dosages are the same as those in Example 1.

[0040] Performance detection The anti-corrosion compositions obtained in different Examples 1 - 15 and Comparative Examples 1 - 4 are respectively subjected to performance detection by using the following detection standards or methods, and the detection results are shown in Table 3.

[0041] Make Malassezia furfur ATCC44344 into a concentration of 10 5For the bacterial suspension of CFU / mL, the anti-corrosion composition obtained in this application was diluted with a culture medium to a sample solution of 15 v / v%. 1 mL of the bacterial suspension was added to 2 mL of the sample solution, and 2 mL of the culture medium was added to the control group. After the bacterial suspension and the sample solution were mixed evenly, timing started. 1 mL of the mixed solution was taken at 5 min, 10 min, and 30 min respectively, and the viable bacteria count method was used to measure the number of viable bacteria to calculate the antibacterial rate.

[0042] Table 3 Performance test results of the anti-corrosion composition The test results in Table 2 show that the anti-corrosion composition containing piroctone olamine obtained in this application has the highest antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min, which are 74.2%, 95.3%, and 99.9% respectively, improving the antibacterial property of the anti-corrosion composition containing piroctone olamine.

[0043] In Examples 1-5, the anti-corrosion compositions containing piroctone olamine in Examples 2-4 have antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min of 70.1-70.3%, 91.2-92.3%, and 99.1-99.4% respectively, all higher than those in Examples 1 and 5; it shows that the weight ratio of ginkgo leaf extract to pentylene glycol of 1:(1-2) is more appropriate, improving the antibacterial property of the anti-corrosion composition containing piroctone olamine. It may be related to the fact that the terpene lactone in the ginkgo leaf extract can open the cutin barrier of piroctone olamine and improve the follicular penetration rate of piroctone olamine.

[0044] In Examples 6-10, the anti-corrosion compositions containing piroctone olamine in Examples 7-9 have antibacterial rates against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min of 71.5-72.1%, 93.5-94.0%, and 99.6-99.7% respectively, all higher than those in Examples 6 and 10; it shows that coating and modifying nano-zinc ricinoleate can improve the antibacterial property of the anti-corrosion composition, and when the mass ratio of chitosan to glyceryl tripalmitate is 1:(1-1.5), it is more appropriate, which can further improve the antibacterial property of the anti-corrosion composition containing piroctone olamine. It may be related to the fact that chitosan can inhibit the growth of bacteria and protect nano-zinc ricinoleate from microbial degradation, and glyceryl tripalmitate can block moisture and oxygen, slowing down the oxidation or hydrolysis reaction of nano-zinc ricinoleate, and the two have a synergistic effect.

[0045] In Examples 11 - 15, the antibacterial rates of the preservative compositions containing piroctone olamine against Malassezia furfur ATCC44344 at 5 min, 10 min, and 30 min in Examples 12 - 14 were 73.8 - 74.2%, 95.0 - 95.3%, and 99.9% respectively, which were all higher than those in Examples 11 and 15; it was shown that it was more appropriate to add sodium cocoyl amphoacetate to the raw materials of the preservative composition, and the weight ratio of sodium lauroyl sarcosinate to sodium cocoyl amphoacetate was 1:(6 - 9), which improved the antibacterial property of the preservative composition containing piroctone olamine. It might be related to the fact that sodium cocoyl amphoacetate could prevent the precipitation of sodium lauroyl sarcosinate, thereby further improving the dispersibility of raw materials such as piroctone olamine, pentylene glycol, and zinc ricinoleate nanosuspension in the preservative composition, thus improving the antibacterial property of the preservative composition.

[0046] In addition, by combining the various index data of the preservative compositions containing piroctone olamine in Comparative Examples 1 - 4 and Example 1, it was found that adding pentylene glycol, ginkgo biloba extract, zinc ricinoleate nanosuspension, and sodium lauroyl sarcosinate to the raw materials of the preservative composition containing piroctone olamine in this application could all improve the antibacterial property of the preservative composition to varying degrees.

[0047] This specific embodiment is only an interpretation of this application and does not limit this application. After reading this specification, those skilled in the art can make modifications to this embodiment without creative contributions as needed, but as long as it is within the scope of the claims of this application, it is protected by the patent law.

Claims

1. An anti-corrosion composition containing piroctone olamine, characterized in that, It comprises the following raw materials in parts by weight: 0.5 - 1.5 parts of piroctone olamine, 30 - 40 parts of propylene glycol, 5 - 10 parts of pentylene glycol, 3 - 7 parts of ginkgo biloba extract, 10 - 15 parts of nano - zinc ricinoleate, and 4 - 6 parts of sodium lauroyl sarcosinate.

2. The antiseptic composition containing piroctone olamine salt according to claim 1, characterized in that, It comprises the following raw materials in parts by weight: 0.8 - 1.2 parts of piroctone olamine, 34 - 36 parts of propylene glycol, 7 - 9 parts of pentylene glycol, 4 - 6 parts of ginkgo biloba extract, 12 - 14 parts of nano - zinc ricinoleate, and 4.5 - 5.5 parts of sodium lauroyl sarcosinate.

3. The antiseptic composition containing piroctone olamine salt according to claim 1, characterized in that, The weight - part ratio of the ginkgo biloba extract to pentylene glycol is 1:(1 - 2).

4. The antiseptic composition containing piroctone olamine salt according to claim 1, characterized in that, The nano - zinc ricinoleate is prepared by coating modification, specifically: Preparing the wall material: adding chitosan and glyceryl tripalmitate into water, stirring and dissolving to obtain the wall material; Coating: adding nano - zinc ricinoleate into the wall material, and spray - drying to obtain modified nano - zinc ricinoleate; The volume ratio of the mass of the nano - zinc ricinoleate to the wall material is 1:(4 - 5); the ratio of the sum of the masses of chitosan and glyceryl tripalmitate to the volume of water is 1:(90 - 100).

5. The antiseptic composition containing piroctone olamine salt according to claim 4, characterized in that: The mass ratio of chitosan to glyceryl tripalmitate is 1:(1 - 1.5).

6. The antiseptic composition containing piroctone olamine salt according to claim 1, characterized in that, The anti - corrosion composition containing piroctone olamine further comprises the following raw materials in parts by weight: 0.5 - 1 part of sodium cocoamphoacetate.

7. The anticorrosive composition containing piroctone olamine salt according to claim 6, characterized in that: The weight - part ratio of sodium lauroyl sarcosinate to sodium cocoamphoacetate is 1:(6 - 9).

8. A method for preparing an anti-corrosion composition containing piroctone olamine according to any one of claims 1-7, characterized in that, It includes the following operation steps: mixing piroctone olamine and propylene glycol, stirring and dissolving, adding the mixture into sodium lauroyl sarcosinate for further mixing, and then adding other raw materials in sequence to obtain the anti - corrosion composition containing piroctone olamine.

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