Novel monitoring and intervention system for parathyroid gland function protection in thyroid cancer operation

Abstract

The invention discloses a novel monitoring and intervention system for parathyroid gland function protection in a thyroid cancer operation, which comprises a nerve monitoring module, a measurement module, a light regulation and control module, an index monitoring module, a data regulation and control module, an intelligent feedback module and a postoperative monitoring module, comprising parathyroid gland specific fluorescent dye and a near-infrared light imaging system and is used for visualizing parathyroid glands in real time during an operation, and the measuring module is used for measuring the concentration value of calcium ions in a measured solution in real time and uploading the concentration value to the system to be stored and collected; blood circulation index data, lactic acid level data and peripheral perfusion parameters are collected through the index monitoring module, the accuracy and diversity of data collection in the operation process are improved, real-time field data collection is conducted on an operation site, and related blood circulation state data are collected through the measurement module and the light regulation and control module.

Description

Technical Field

[0001] The present invention relates to the technical field of thyroid surgery, and particularly to a novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery. Background Art

[0002] Parathyroid surgery is a common surgery for treating hyperparathyroidism. The parathyroid glands are located behind the thyroid gland, and their main function is to regulate calcium and phosphorus metabolism in the body. The surgery usually includes parathyroidectomy to treat primary, secondary or tertiary hyperparathyroidism. During parathyroid surgery, maintaining a stable blood circulation state is crucial for the success of the surgery. Changes in blood circulation may affect the patient's overall condition and lead to surgical complications. Monitoring the blood circulation state helps to promptly detect and handle intraoperative circulatory system abnormalities, ensuring the smooth progress of the surgery and patient safety.

[0003] In Chinese Patent 202110696763.4, only imaging can be used to guide the diagnosis of parathyroid function during thyroid surgery, and it is impossible to perform good monitoring and intervention during thyroid surgery. Therefore, the present invention proposes a novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery to solve the problems existing in the prior art. Summary of the Invention

[0004] In view of the above problems, the object of the present invention is to propose a novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery collects blood circulation index data, lactate level data, and peripheral perfusion parameters through an index monitoring module, improves the accuracy and diversity of data collection during the surgery process, performs real-time on-site data collection of the surgery site, collects relevant blood circulation state data through a measurement module and a light regulation module, and compares and judges the collected blood circulation state data.

[0005] To achieve the object of the present invention, the present invention is realized through the following technical solutions: A novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery, including a nerve monitoring module, a measurement module, a light regulation module, an index monitoring module, a data regulation module, an intelligent feedback module, and a postoperative monitoring module;

[0006] The nerve monitoring module is used to monitor the function of the recurrent laryngeal nerve in real time, including a parathyroid-specific fluorescent dye and a near-infrared light imaging system for real-time visualization of the parathyroid glands during the surgery;

[0007] The measurement module is used to measure the concentration value of calcium ions in the solution to be measured in real time and upload the concentration value to the system for storage and collection;

[0008] A regulation module, which is used to receive the control instructions of the system, regulate the light flux, and make the regulated light irradiate the solution to be measured;

[0009] An index monitoring module, which is used to detect during parathyroid surgery, collect the blood circulation index data, lactate level data and peripheral perfusion parameters of the patient's body restraint through a body index instrument, and transmit the blood circulation index data, lactate level data and peripheral perfusion parameters to the measurement module and the regulation module;

[0010] A data configuration module, which is used to configure the measurement module, generate control instructions according to the calcium ion concentration value uploaded by the measurement module, and send the control instructions to the regulation module to realize the monitoring and regulation of parathyroid hormone secretion;

[0011] An intelligent feedback module, the system provides real-time feedback and suggestions to the surgeon according to the monitored data and intelligent analysis results, and the feedback includes adjusting the surgical strategy, protection measures and taking preventive interventions;

[0012] A postoperative monitoring module, which is used to track the recovery of the patient's parathyroid function. Postoperative management includes supplementing calcium and vitamin D, and monitoring blood calcium levels and parathyroid hormone levels.

[0013] A further improvement lies in that: the nerve monitoring module monitors the electrical activity of the recurrent laryngeal nerve in real time, places the monitoring electrode on the laryngeal muscle, fixes the electrode on the cricoid cartilage, monitors the electrical activity of the recurrent laryngeal nerve, and provides immediate feedback on the integrity of nerve function.

[0014] A further improvement lies in that: the measurement module includes a calcium ion measurement electrode, which is used to detect the calcium ion concentration in the solution to be measured and convert the calcium ion concentration into an electrical signal, including a signal amplifier, a signal conversion circuit, a numerical calculation module and a communication interface.

[0015] A further improvement lies in that: the regulation module realizes the regulation of the light flux, makes the regulated light irradiate the solution to be measured, and the regulation module includes a communication interface for establishing a connection with other modules, receiving control instructions, a light source, and a light source drive circuit for making the light source work according to the control instructions.

[0016] A further improvement lies in that: the arterial oxygen saturation data and central venous pressure data are extracted from the index monitoring module, and combined with the peripheral perfusion parameters and lactate level data, a numerical fluid dynamics model analysis is carried out on the blood pressure fluctuation range of the patient's body-restrained heart, and at the same time, the muscle and nervous system data of the patient's body restraint are collected.

[0017] A further improvement lies in that: the data configuration module is used to configure the regulation module, generate a control instruction according to the calcium ion concentration value uploaded by the measurement module, and send the control instruction to the data configuration module to realize the monitoring and regulation of parathyroid PTH secretion.

[0018] A further improvement lies in that: the intelligent feedback module collects data from various sensors and monitoring devices in real time, including nerve monitoring and parathyroid-specific fluorescence imaging. The module processes and analyzes the received data, and uses preset algorithms and models to identify potential risks and abnormal conditions.

[0019] A further improvement lies in that: the postoperative monitoring module imports the data generated during the operation into the postoperative monitoring module to conduct a comprehensive postoperative evaluation of the patient, including the determination of blood calcium level and parathyroid hormone level, as well as the observation of symptoms and signs.

[0020] A further improvement lies in that: the system further includes a display module for displaying the calcium ion concentration value and the light source working parameters, providing an intuitive user interface.

[0021] A further improvement lies in that: the measurement module, the light regulation module, the index monitoring module, and the data regulation module communicate through a wireless communication module.

[0022] The beneficial effects of the present invention are as follows: through the mutual cooperation of the nerve monitoring module, the measurement module, the light regulation module, the index monitoring module, the data regulation module, the intelligent feedback module, and the postoperative monitoring module, the index monitoring module collects blood circulation index data, lactic acid level data, and peripheral perfusion parameters, improving the accuracy and diversity of data collection during the operation, performing real-time on-site data collection of the operation site, collecting relevant blood circulation state data through the measurement module and the light regulation module, and comparing and judging the collected blood circulation state data. Through the measurement module, a parathyroid PTH secretion monitoring and regulation system is obtained, and the working state of the light regulation module is controlled according to the calcium ion concentration of the solution to be measured, so as to detect and adjust the secretion of parathyroid PTH, realize real-time monitoring of the calcium ion concentration in the solution to be measured, and regulate the PTH secretion according to the calcium ion concentration to achieve the metabolic balance of PTH, assisting doctors to timely discover changes in blood circulation and calcium ion concentration states and potential safety risks. Description of the Drawings

[0023] In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the following drawings are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0024] Figure 1 This is a schematic diagram of the system of the present invention. Specific embodiments

[0025] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0026] In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the communication inside two components. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0027] In Document 202110696763.4, by applying white light imaging technology in an endoscope to obtain clear color images of the surgical field background, near-infrared fluorescence technology is used to locate the parathyroid gland, laser speckle flow imaging technology is used to detect the blood supply of the parathyroid gland, and the decorrelation algorithm is used to process the laser speckle, avoiding the disadvantages of the traditional algorithm such as the small dynamic range of the contrast ratio K and low signal-to-noise ratio. Then, combined with the fusion registration technology, the decorrelated speckle fusion image of the parathyroid gland is displayed, so as to understand whether its function is lost and whether transplantation is needed, and to guide the diagnosis of parathyroid function during thyroid surgery, reducing the occurrence of postoperative hypoparathyroidism. However, it cannot be well monitored during thyroid surgery. The system proposed in this application provides a basis for optimizing the surgical process for surgical personnel, ensuring surgical safety, integrating multiple data acquisition and analysis devices and processes, and saving labor operation costs.

[0028] According to Figure 1 As shown, this embodiment provides a new monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery, including a nerve monitoring module, a measurement module, a light regulation module, an index monitoring module, a data regulation module, an intelligent feedback module, and a postoperative monitoring module;

[0029] The nerve monitoring module is used to monitor the function of the recurrent laryngeal nerve in real time, including a parathyroid-specific fluorescent dye and a near-infrared light imaging system for visualizing the parathyroid gland in real time during surgery;

[0030] A measurement module, which is used to measure the concentration value of calcium ions in the solution to be measured in real time, and upload the concentration value to the system for storage and collection;

[0031] A regulation module, which is used to receive the control instructions of the system, realize the regulation of the light flux, and make the regulated light irradiate the solution to be measured;

[0032] An index monitoring module, which is used to detect during parathyroid surgery, collect the blood circulation index data, lactate level data and peripheral perfusion parameters of the patient's body constraints through a body index instrument, and transmit the blood circulation index data, lactate level data and peripheral perfusion parameters to the measurement module and the regulation module;

[0033] A data configuration module, which is used to configure the measurement module, generate control instructions according to the calcium ion concentration value uploaded by the measurement module, and send the control instructions to the regulation module to realize the monitoring and regulation of parathyroid hormone secretion;

[0034] An intelligent feedback module, the system provides real-time feedback and suggestions to the surgeon according to the monitored data and intelligent analysis results, and the feedback includes adjusting the surgical strategy, protection measures and taking preventive interventions;

[0035] A postoperative monitoring module, which is used to track the recovery of the patient's parathyroid function. Postoperative management includes supplementing calcium and vitamin D, as well as monitoring blood calcium levels and parathyroid hormone levels.

[0036] The nerve monitoring module monitors the electrical activity of the recurrent laryngeal nerve in real time. The monitoring electrode is placed on the laryngeal muscle, and the electrode is fixed on the cricoid cartilage to monitor the electrical activity of the recurrent laryngeal nerve, providing immediate feedback on the integrity of the nerve function. When abnormal nerve electrical activity is detected, the nerve monitoring module will issue a warning, indicating the risk of nerve injury to the surgeon.

[0037] The measurement module includes a calcium ion measurement electrode, which is used to detect the calcium ion concentration in the solution to be measured and convert the calcium ion concentration into an electrical signal; a signal amplifier, which is used to amplify the electrical signal by a preset multiple; a signal conversion circuit, which is used to convert the amplified electrical signal into a digital signal; a numerical calculation module, which is used to convert the digital signal into a calcium ion concentration value. The numerical calculation module uses a single-chip microcomputer to convert the calcium ion concentration value. A communication interface is used to establish a connection with the upper-level subsystem to realize data interaction. The reason for choosing the calcium ion concentration as the measurement target parameter of the solution to be measured is determined according to the characteristics of the solution to be measured. The solution to be measured is usually human body fluid, a specially configured solution to be measured, which contains PTH and expresses a vector that regulates the secretion of parathyroid PTH. PTH is an important calcium and phosphorus homeostasis regulator secreted by the chief cells of the parathyroid gland.

[0038] The regulation module realizes the regulation of luminous flux, so that the regulated light irradiates the solution to be measured. The regulation module includes a communication interface for establishing a connection with other modules and receiving control instructions, a light source, and a light source drive circuit for making the light source work according to the control instructions. The light source is an LED lamp panel, and the wavelength of the LED is selected within the blue light band. There is a carrier for regulating the secretion of parathyroid PTH. The carrier includes a photosensitive gene and a PTH promoter that specifically recognizes parathyroid chief cells. The photosensitive gene is a gene that can express a cell membrane channel protein sensitive to blue light. The photosensitive protein opens the channel under irradiation at a specific wavelength, such as 470 nm, allowing cations to enter the cytoplasm, resulting in an increase in the cell membrane potential, thereby realizing the regulation of cell activity and achieving the purpose of highly spatiotemporally precisely and specifically regulating parathyroid chief cells.

[0039] The index monitoring module extracts arterial oxygen saturation data, central venous pressure data, and combines peripheral perfusion parameters and lactate level data to perform numerical hydrodynamic model analysis on the blood pressure fluctuation range of the heart with the patient's body restrained. At the same time, it collects muscle and nervous system data of the patient's body restrained, and performs electromyogram analysis on the collected muscle and nervous system data to obtain the frequency components of the electromyographic signal. When the frequency components of the electromyographic signal show that the low, medium, and high frequency parameters in the muscle and nervous system data exceed the physiological safety value, blood circulation status monitoring is performed and a safety prompt is issued. When the low, medium, and high frequency parameters in the muscle and nervous system data are lower than the physiological safety value, the operation continues.

[0040] The data configuration module is used to configure the regulation module, generate a control instruction according to the calcium ion concentration value uploaded by the measurement module, and send the control instruction to the data configuration module to realize the monitoring and regulation of parathyroid PTH secretion. The data configuration module generates a control instruction according to the calcium ion concentration value uploaded by the measurement module. When the calcium ion concentration value is higher than the first threshold, according to the difference between the calcium ion concentration value and the first threshold, a light illumination strategy is determined, and the light illumination strategy is generated into a control instruction. The light illumination strategy includes at least one parameter of light intensity, driving light source delay time, and light illumination frequency. The larger the difference, the higher the calcium ion concentration, and the stronger the intensity and duration of light illumination are required.

[0041] The intelligent feedback module collects data from various sensors and monitoring devices in real time, including nerve monitoring and parathyroid-specific fluorescence imaging. The module processes and analyzes the received data, uses preset algorithms and models to identify potential risks and abnormal situations. According to the analysis results, the intelligent feedback module evaluates the risk of parathyroid function impairment and determines whether intervention measures need to be taken. The module feeds back the analysis results and risk assessment to the surgeon in a visual form in real time for display through a display screen.

[0042] The postoperative monitoring module imports the data generated during the operation into the postoperative monitoring module to comprehensively evaluate the patient after the operation, including the determination of blood calcium levels and parathyroid hormone levels, as well as the observation of symptoms and signs. Regularly monitor the patient's blood calcium and PTH levels, as well as possible hypocalcemia symptoms, and analyze to evaluate the patient's recovery and treatment effects.

[0043] The system also includes a display module for displaying the calcium ion concentration value and the light source operating parameters, providing an intuitive user interface that enables surgeons to easily view the monitoring data, risk assessment, and intervention suggestions.

[0044] The measurement module, light regulation module, index monitoring module, and data regulation module communicate through the wireless communication module.

[0045] When the new monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery is used, multiple internal modules quickly identify the safety risks caused by changes in the local blood circulation status and calcium ion concentration values during the operation, and make timely feedback to help the surgical staff optimize the plan, eliminate the potential damage caused by changes in the local blood circulation status. This system can effectively enhance the data acquisition ability during parathyroid surgery, ensure the timely control of the surgical staff, optimize the surgical process in a timely manner to reduce the pollution of the local blood circulation status, and ensure surgical safety.

[0046] The above has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited by the above embodiments. The above embodiments and the descriptions in the specification only illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed. The scope of protection of the present invention is defined by the appended claims and their equivalents.

Claims

1. A novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery, characterized in that, It includes a nerve monitoring module, a measurement module, a light regulation module, an index monitoring module, a data regulation module, an intelligent feedback module, and a postoperative monitoring module; The nerve monitoring module is used to monitor the function of the recurrent laryngeal nerve in real time, including a parathyroid-specific fluorescent dye and a near-infrared light imaging system for real-time visualization of the parathyroid gland during surgery; The measurement module is used to measure the concentration value of calcium ions in the solution to be measured in real time, and upload the concentration value to the system for storage and collection; The regulation module is used to receive the control instructions of the system, realize the regulation of the light flux, and make the regulated light irradiate the solution to be measured; The index monitoring module is used to detect during parathyroid surgery, collect the blood circulation index data, lactate level data, and peripheral perfusion parameters of the patient's body restraint through a body index instrument, and transmit the blood circulation index data, lactate level data, and peripheral perfusion parameters to the measurement module and the regulation module; The data configuration module is used to configure the measurement module, generate control instructions according to the calcium ion concentration value uploaded by the measurement module, and send the control instructions to the regulation module to realize the monitoring and regulation of parathyroid hormone secretion; The intelligent feedback module provides real-time feedback and suggestions to the surgeon according to the monitored data and intelligent analysis results. The feedback includes adjusting the surgical strategy, protection measures, and taking preventive interventions; The postoperative monitoring module is used to track the recovery of the patient's parathyroid function. Postoperative management includes supplementing calcium and vitamin D, and monitoring blood calcium levels and parathyroid hormone levels.

2. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The nerve monitoring module monitors the electrical activity of the recurrent laryngeal nerve in real time, places the monitoring electrode on the laryngeal muscle, fixes the electrode on the cricoid cartilage, monitors the electrical activity of the recurrent laryngeal nerve, and provides immediate feedback on the integrity of the nerve function.

3. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The measurement module includes a calcium ion measurement electrode for detecting the calcium ion concentration in the solution to be measured, converting the calcium ion concentration into an electrical signal, which includes a signal amplifier, a signal conversion circuit, a numerical calculation module, and a communication interface.

4. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The regulation module realizes the regulation of the light flux, makes the regulated light irradiate the solution to be measured. The regulation module includes a communication interface for establishing a connection with other modules and receiving control instructions, a light source, and a light source drive circuit for making the light source work according to the control instructions.

5. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, characterized in that: The index monitoring module extracts arterial oxygen saturation data and central venous pressure data, and combines peripheral perfusion parameters and lactate level data to perform numerical fluid dynamics model analysis on the blood pressure fluctuation range of the patient's body-restrained heart.

6. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The data configuration module is used to configure the regulation module, generate control instructions according to the calcium ion concentration value uploaded by the measurement module, and send the control instructions to the data configuration module to realize the monitoring and regulation of parathyroid PTH secretion.

7. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The intelligent feedback module collects data from various sensors and monitoring devices in real time, including nerve monitoring and parathyroid-specific fluorescence imaging. The module processes and analyzes the received data, and uses preset algorithms and models to identify potential risks and abnormal situations.

8. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The postoperative monitoring module imports the data generated during the operation into the postoperative monitoring module to comprehensively evaluate the patient after the operation, including the determination of blood calcium level and parathyroid hormone level, as well as the observation of symptoms and signs. Regularly monitor the patient's blood calcium and PTH levels, as well as possible hypocalcemia symptoms, and conduct analysis to evaluate the patient's recovery and treatment effects.

9. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, wherein: The system further includes a display module for displaying the calcium ion concentration value and the light source working parameters, providing an intuitive user interface.

10. The novel monitoring and intervention system for protecting parathyroid function during thyroid cancer surgery according to claim 1, characterized in that: The measurement module, the light regulation module, the index monitoring module, and the data regulation module communicate through a wireless communication module.

Images