Visceral organ perfusion device

Abstract

An organ perfusion device (1) is provided with: a chamber (100) that is open to the atmosphere and accommodates an organ; an inflow flow path (220) that receives the perfusate to be delivered to the organ; and an outflow flow path (210), one end of which can be connected to an entrance blood vessel of an organ, for delivering the perfusate received by the inflow flow path toward the entrance blood vessel. The chamber (100) is provided with a connection port (120) which is configured so as to be openable and closable and is configured so as to be connectable to the inflow flow path (220). In an organ perfusion device (1), an open loop is formed by connecting an end (401) of an inflow channel (220) that receives a perfusate to a connection port (120), and a closed loop is formed by closing the connection port and connecting an end (402) of the inflow channel that receives the perfusate to an exit blood vessel of an organ.

Description

Technical Field

[0001] The present invention relates to an organ perfusion device. Background Art

[0002] As a device for removing an organ for transplantation and preserving the organ in a state where its function is maintained, an organ perfusion device that perfuses a perfusion solution into the organ has been developed.

[0003] There are cases where organ perfusion is performed using an open system circuit in which at least a part of the circuit through which the perfusion solution circulates is open to the atmosphere, and cases where organ perfusion is performed using a closed system circuit in which no part open to the atmosphere is provided in the circuit through which the perfusion solution circulates.

[0004] Japanese Unexamined Patent Application Publication No. 2020-002062 (Patent Document 1) discloses an organ perfusion device in which one end of an inflow pipe is connected to the renal artery of a kidney and one end of an outflow pipe is connected to the renal vein of the kidney.

[0005] Prior Art Documents

[0006] Patent Documents

[0007] Patent Document 1: Japanese Unexamined Patent Application Publication No. 2020-002062 Summary of the Invention

[0008] Problems to be Solved by the Invention

[0009] Conventionally, organ perfusion devices have been designed specifically for each circuit. Therefore, the circuits that can be used by the user of the organ perfusion device are necessarily determined according to the type of the organ perfusion device at hand.

[0010] However, each of the open system circuit and the closed system circuit has advantages and disadvantages, and the inventors have found problems in determining the circuits that can be used according to the type of the organ perfusion device.

[0011] An object of the present disclosure is to provide an organ perfusion device that allows a user of the organ perfusion device to arbitrarily select an open system circuit and a closed system circuit.

[0012] Means for Solving the Problems

[0013] The organ perfusion device of the present disclosure is an organ perfusion device for perfusing a perfusion fluid into an organ. The organ perfusion device includes: a chamber that is open to the atmosphere and is used to accommodate the organ; an inflow flow path that is connected to the inlet blood vessel of the organ; and one or more outflow flow paths that are fluidly connected to the inflow flow path and are disposed on the outlet blood vessel side of the organ. The chamber includes a connection port that is configured to be able to be opened and closed and is configured to be able to be connected to the one or more outflow flow paths. The one or more outflow flow paths are configured to be selectively connected to either the connection port or the outlet blood vessel. In the organ perfusion device, an open system circuit is formed by connecting the one or more outflow flow paths to the connection port, and a closed system circuit is formed by connecting the one or more outflow flow paths to the outlet blood vessel.

[0014] Effects of the Invention

[0015] According to the present disclosure, a user of the organ perfusion device can arbitrarily select an open system circuit and a closed system circuit. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram showing the overall structure of the organ perfusion device.

[0017] Figure 2 It is a schematic structural diagram showing the overall structure of the organ perfusion device in which an open system circuit is formed.

[0018] Figure 3 It is a schematic structural diagram showing the overall structure of the organ perfusion device in which a closed system circuit is formed.

[0019] Figure 4 It is a side view of the chamber.

[0020] Figure 5 It is a diagram showing a part of the closed system circuit.

[0021] Figure 6 It is a flowchart showing a replenishment method. DETAILED DESCRIPTION

[0022] Hereinafter, embodiments of the present disclosure will be described in detail with reference to the drawings. In addition, the same or corresponding parts in the drawings are denoted by the same reference numerals, and their descriptions will not be repeated.

[0023] [Overall Structure of Organ Perfusion Device]

[0024] Figure 1It is a schematic diagram showing the overall structure of the organ perfusion device 1. The organ perfusion device 1 is a device for flowing a perfusion fluid through an organ removed from a donor to preserve and / or evaluate the removed organ. The "donor" can be either a human or a non-human animal. Regarding the "organ", as long as it is an organ such as a heart, kidney, lung, pancreas, stomach, small intestine, large intestine, testis, ovary, eyeball, etc., which has an inlet blood vessel for blood inflow and an outlet blood vessel for blood outflow, it can be any organ. In addition, as long as the organ has one or more inlet blood vessels and outlet blood vessels respectively. In the present embodiment, as an example of the organ, the liver 10 removed from a human is taken for illustration. The "perfusion fluid" is appropriately selected according to the purpose of perfusion. For example, it is physiological saline, an organ preservation solution, blood, etc.

[0025] The organ perfusion device 1 includes: a chamber 100 that receives the liver 10; an outflow channel 210 disposed on the outlet blood vessel side of the liver 10; a reservoir 400 that stores the perfusion fluid from the outflow channel 210; and an inflow channel 220 that is connected to the inlet blood vessel of the liver 10. In addition, a reservoir 400 is provided between the outflow channel 210 and the inflow channel 220, and although the two channels are not directly connected, they are fluidly connected.

[0026] The chamber 100 is a container for accommodating the liver 10. An opening 102 is provided at the upper part of the chamber 100, so the inside of the chamber 100 is open to the atmosphere and exposed to the atmosphere. In addition, the chamber 100 may also include a lid for covering the opening 102. In addition, as long as the chamber 100 is open to the atmosphere of the space where the chamber 100 is provided. For example, when the chamber 100 is provided in a nitrogen atmosphere, the chamber 100 is open to the nitrogen atmosphere.

[0027] The chamber 100 includes a connection port 120 that is configured to be able to be opened and closed and is configured to be able to be connected to the outflow channel 210. The connection port 120 is configured to be able to mount either the lid 120a or the outflow channel 210.

[0028] In addition, the chamber 100 is connected to a waste liquid channel 240 for transporting the perfusion fluid in the chamber 100 to a waste liquid tank (not shown). The waste liquid channel 240 includes a waste liquid valve 242 for opening and closing the waste liquid channel 240. The perfusion fluid in the chamber 100 can be transported to the waste liquid tank through the waste liquid channel 240 by opening the waste liquid valve 242. In addition, the detailed structure of the chamber 100 will be described later with reference to Figure 4 and Figure 5 to describe.

[0029] The outflow channel 210 is a channel for receiving the perfusion fluid discharged from the liver 10. One end of the outflow channel 210 is configured to be connectable to the reservoir 400, and the other end is configured to be selectively connectable to either the connection port 120 or the hepatic vein 13.

[0030] In the present embodiment, the outflow channel 210 includes a first connection channel 212 and a second connection channel 214. One end of the first connection channel 212 is configured to be connectable to the connector 401 formed in the reservoir 400, and the other end is configured to be connectable to the connection port 120. One end of the second connection channel 214 is configured to be connectable to the connector 402 formed in the reservoir 400, and the other end is configured to be connectable to the hepatic vein 13.

[0031] The reservoir 400 is a container for storing the perfusion fluid and is a sealed container. The reservoir 400 is connected to the outflow channel 210 and the inflow channel 220. The perfusion fluid transported through the outflow channel 210 is transported to the reservoir 400. The perfusion fluid transported to the reservoir 400 is transported from the reservoir 400 to the liver 10 through the inflow channel 220.

[0032] The reservoir 400 includes a liquid level sensor 410 that measures the liquid level height of the perfusion fluid in the reservoir 400. In addition, the reservoir 400 is connected to a replenishment channel 230. The replenishment channel 230 receives the perfusion fluid replenished to the reservoir 400 to replenish the perfusion fluid to the reservoir 400. The replenishment channel 230 includes a replenishment valve 232 that opens and closes the replenishment channel 230.

[0033] In the present embodiment, the reservoir 400 includes at least five connectors 401 to 405. The connector 401 is configured to be connectable to the first connection channel 212. The connector 402 is configured to be connectable to the second connection channel 214. The connector 403 is configured to be connectable to the first inflow channel 222 of the inflow channel 220. The connector 404 is configured to be connectable to the second inflow channel 224 of the inflow channel 220. The connector 405 is configured to be connectable to the replenishment channel 230.

[0034] The inflow channel 220 is a channel that connects to the inlet blood vessels of the liver 10 as an organ and transports the perfusion fluid toward the liver 10. One end of the inflow channel 220 is connected to the inlet blood vessels of the organ, and the other end is connected to the reservoir 400. The liver 10 has two inlet blood vessels, the hepatic artery 11 and the portal vein 12. Therefore, in the present embodiment, the inflow channel 220 includes: a first inflow channel 222 that is connected to the hepatic artery 11; and a second inflow channel 224 that is connected to the portal vein 12. The first inflow channel 222 is a channel that connects the reservoir 400 and the hepatic artery 11. The second inflow channel 224 is a channel that connects the reservoir 400 and the portal vein 12.

[0035] Thus, by connecting the first inflow passage 222 and the second inflow passage 224 to the liver 10, the perfusion fluid in the reservoir 400 flows through the first inflow passage 222 and is delivered from the hepatic artery 11 to the liver 10, and also flows through the second inflow passage 224 and is delivered from the portal vein 12 to the liver 10. In addition, bile produced by the liver 10 is delivered to the container 252 through the bile passage 250 connected to the bile duct 14.

[0036] In addition, the organ perfusion device 1 includes a pump 300, a supply device 600, a flow meter 700, and a pressure gauge 800.

[0037] The pump 300 is a device for delivering the perfusion fluid from the reservoir 400 toward the inlet blood vessel, and the pump 300 is provided in the inflow passage 220 in the present embodiment. With the driving of the pump 300, the perfusion fluid in the reservoir 400 is delivered to the inlet blood vessel through the inflow passage 220. In the present embodiment, the organ perfusion device 1 includes a first pump 310 and a second pump 320 as the pump 300. The first pump 310 is a device for delivering the perfusion fluid from the reservoir 400 toward the hepatic artery 11, and the first pump 310 is provided in the first inflow passage 222. The second pump 320 is a device for delivering the perfusion fluid from the reservoir 400 toward the portal vein 12, and the second pump 320 is provided in the second inflow passage 224.

[0038] The supply device 600 supplies oxygen to the perfusion fluid to be delivered to the organ, and the supply device 600 is provided in the inflow passage 220 in the present embodiment. For example, the supply device 600 is an artificial lung that supplies oxygen to the perfusion fluid to increase the oxygen concentration in the perfusion fluid. In the present embodiment, the organ perfusion device 1 includes a first supply device 610 and a second supply device 620 as the supply device 600. The first supply device 610 supplies oxygen to the perfusion fluid flowing through the first inflow passage 222, and the first supply device 610 is provided in the first inflow passage 222. The second supply device 620 supplies oxygen to the perfusion fluid flowing through the second inflow passage 224, and the second supply device 620 is provided in the second inflow passage 224.

[0039] The flow meter 700 measures the flow rate of the perfusion fluid flowing through the inflow passage 220. In the present embodiment, the organ perfusion device 1 includes a first flow meter 710 that measures the perfusion fluid flowing through the first inflow passage 222 and a second flow meter 720 that measures the perfusion fluid flowing through the second inflow passage 224 as the flow meter 700.

[0040] The pressure gauge 800 measures the pressure of the perfusion fluid flowing through the inflow passage 220. In the present embodiment, the organ perfusion device 1 includes a first pressure gauge 810 that measures the pressure of the perfusion fluid flowing through the first inflow passage 222 and a second pressure gauge 820 that measures the pressure of the perfusion fluid flowing through the second inflow passage 224 as the pressure gauge 800.

[0041] The control device 500 includes a CPU (Central Processing Unit) 501 as an arithmetic unit, a RAM (Random Access Memory) 502, and a storage device 503.

[0042] The CPU 501 controls the operations of the respective parts of the organ perfusion device 1 by reading out the programs stored in the storage device 503 and executing them. For example, the CPU 501 controls the pump by executing this program. In addition, in Figure 1 the example, a structure in which the CPU 501 is one is illustrated, but the organ perfusion device 1 may also be configured to have a plurality of CPUs.

[0043] The storage device 503 is implemented by a non-volatile storage device such as a ROM (Read Only Memory) or a hard disk. The storage device 503 stores programs executed by the CPU 501, data used by the CPU 501, and the like. This program may also be stored in a non-transitory computer-readable medium.

[0044] The control device 500 receives the measurement results from the liquid level sensor 410, the first flowmeter 710, the second flowmeter 720, the first pressure gauge 810, and the second pressure gauge 820, respectively. The control device 500 controls the opening and closing of the replenishing valve 232 according to the measurement result of the liquid level sensor 410. The control device 500 controls the first pump 310 according to the respective measurement results of the first flowmeter 710 and the first pressure gauge 810, and controls the second pump 320 according to the respective measurement results of the second flowmeter 720 and the second pressure gauge 820.

[0045] In addition, the control device 500 according to the present embodiment is connected to an input device 504 for inputting information capable of identifying whether the circuit configured in the organ perfusion device 1 is an open-system circuit or a closed-system circuit. The input device 504 can also accept input according to mechanical operations such as switches, for example. In addition, when a display device such as a liquid crystal display is further provided, the input device 504 may be composed of a touch panel, a keyboard, a mouse, or the like.

[0046] [Open-system circuit and closed-system circuit]

[0047] The organ perfusion device 1 includes: an outflow flow path 210 configured to be selectively connectable to either a connection port 120 or a hepatic vein 13; and a chamber 100 having the connection port 120. In the organ perfusion device 1, an open-loop circuit is formed by connecting the outflow flow path 210 to the connection port 120, and a closed-loop circuit is formed by connecting the outflow flow path 210 to the hepatic vein 13 of the liver 10. Hereinafter, with reference to Figure 2 and Figure 3 the open-loop circuit and the closed-loop circuit will be described.

[0048] Figure 2 FIG. is a schematic structural diagram showing the overall structure of the organ perfusion device in which an open-loop circuit is formed. Figure 3 FIG. is a schematic structural diagram showing the overall structure of the organ perfusion device in which a closed-loop circuit is formed. In Figure 2 and Figure 3 some of the reference numerals are omitted to simplify the drawings.

[0049] (Open-loop circuit)

[0050] With reference to Figure 2 , an open-loop circuit is formed by connecting the end of the outflow flow path 210 that receives the perfusion fluid to the connection port 120. More specifically, one end of the first connection flow path 212 is connected to a connector 401 formed in a liquid storage tank 400, and the other end of the first connection flow path 212 is connected to the connection port 120. In addition, since the second connection flow path 214 is not required in the open-loop circuit, there is no need to connect the second connection flow path 214 to the connector 402. A lid 402a is attached to the connector 402.

[0051] The perfusion fluid in the chamber 100 is transported from the connection port through the first connection flow path 212 to the liquid storage tank 400. With the driving of each of the first pump 310 and the second pump 320, the perfusion fluid in the liquid storage tank 400 is transported from the hepatic artery 11 or the portal vein 12 to the liver 10 through the first inflow flow path 222 and the second inflow flow path 224, respectively. The perfusion fluid transported to the liver 10 is discharged into the chamber 100 in an atmosphere-open manner from the hepatic vein 13. The discharged perfusion fluid is transported to the liver 10 again through the first connection flow path 212, the liquid storage tank 400, the first inflow flow path 222, and the second inflow flow path 224. In this way, an open-loop circuit is formed by connecting the first connection flow path 212 to the connection port 120.

[0052] (Closed-loop circuit)

[0053] With reference to Figure 3, a closed-loop circuit is formed by connecting the end of the outflow passage 210 that receives the perfusion fluid to the hepatic vein 13 and closing the connection port 120. More specifically, one end of the second connection passage 214 is connected to the connector 402 formed in the liquid storage tank 400, and the other end of the second connection passage 214 is connected to the hepatic vein 13. Additionally, in the closed-loop circuit, the first connection passage 212 is not required, so there is no need to connect the first connection passage 212 to the connector 401. The lid 401a is installed on the connector 401.

[0054] In addition, the supplementary passage 230 is connected to the infusion bag 234, and the opening and closing of the supplementary valve 232 are performed according to the measurement result of the liquid level sensor 410 to supplement the perfusion fluid from the infusion bag 234. The detailed supplementary method will be described later with reference to Figure 6 to describe the detailed supplementary method.

[0055] The perfusion fluid delivered to the liver is discharged into the liquid storage tank 400 through the second connection passage 214 from the hepatic vein 13 in a manner not open to the atmosphere. Since the liquid storage tank 400 is a closed container, the perfusion fluid is discharged into the liquid storage tank 400 in a manner not open to the atmosphere. Similarly to the open-loop circuit, with the driving of each of the first pump 310 and the second pump 320, the perfusion fluid in the liquid storage tank 400 is delivered to the liver 10. Thus, a closed-loop circuit is formed by closing the connection port 120 and connecting the second connection passage 214 to the hepatic vein 13.

[0056] (Advantages and disadvantages of each of the open-loop circuit and the closed-loop circuit)

[0057] In the open-loop circuit, the hepatic vein 13 is open to the atmosphere, so the risk of applying excessive pressure inside the liver 10 is low. Additionally, regarding the administration of reagents and the supplementation of the perfusion fluid, these operations can be easily performed as long as they are directly carried out from the chamber 100 open to the atmosphere.

[0058] However, in the open-loop circuit, the perfusion fluid returning to the liver 10 comes into contact with the atmosphere inside the chamber 100. Therefore, there is a risk of contamination. Additionally, in order to discharge the perfusion fluid from the hepatic vein 13 into the chamber 100 and return the perfusion fluid discharged into the chamber 100 to the liver 10, not only is it necessary to fill the passage with the perfusion fluid but also to fill the inside of the chamber 100 with the perfusion fluid, and a large amount of perfusion fluid is required in the open-loop circuit.

[0059] On the other hand, in the closed-loop circuit, the perfusion fluid does not come into contact with the atmosphere, so the risk of contamination is low. Additionally, there is no need to fill the inside of the chamber 100 with the perfusion fluid for perfusion, so the total amount of the perfusion fluid used can be reduced, and it is easy to analyze metabolites, etc. from the liver 10 in the closed-loop circuit.

[0060] However, in a closed-loop system, since it is not open to the atmosphere, there is a risk of applying excessive pressure inside the liver 10, or a control system that does not apply excessive pressure needs to be constructed. In addition, since the perfusion fluid flows through the closed loop, it takes effort to administer reagents to the perfusion fluid or replenish the perfusion fluid.

[0061] Thus, each of the open-loop system and the closed-loop system has advantages / disadvantages. As Figure 2 and Figure 3 shown, the organ perfusion device 1 according to the present embodiment can be both an open-loop system and a closed-loop system by providing an openable / closable connection port 120 configured to be connectable to the inflow passage 220 in the chamber 100. Therefore, a user such as a doctor can appropriately select a loop according to the state of the organ, the purpose of perfusion, etc., taking into account the advantages / disadvantages of each loop by using the organ perfusion device 1 according to the present embodiment.

[0062] [Structure of the chamber]

[0063] Refer to Figure 4 to describe the detailed structure of the chamber 100. Figure 4 is a side view of the chamber. A convex portion 140 protruding outward toward the side opposite to the side where the liver 10 is housed is formed on at least a part of the bottom surface of the chamber 100.

[0064] A connection port 120 and a waste liquid port 122 are formed in the convex portion 140. Both the connection port 120 and the waste liquid port 122 are provided so as to face the outside of the chamber 100 and both have a cylindrical shape.

[0065] A cylindrical connector 130 is provided in the chamber 100 so as to penetrate the side surface. Refer to Figure 5 to describe the connector 130 provided on the side surface of the chamber. Figure 5 is a diagram showing a part of the closed-loop system. In addition, in Figure 5 some reference numerals and drawings are omitted to simplify the drawing.

[0066] Refer to Figure 5 , the connector 130 includes: a first connection portion 132 provided so as to face inward from the wall of the chamber 100; and a second connection portion 134 provided so as to face outward from the wall of the chamber 100.

[0067] The second connection flow path 214 includes two flow paths 214a and 214b connected by a connector 130. The flow path 214a is configured as a cannula that can be mounted at one end to the hepatic vein 13. The other end of the flow path 214a can be connected to the first connection portion 132 of the connector 130. The flow path 214b can be connected to the second connection portion 134 of the connector 130 and the connector 402 of the liquid storage tank 400.

[0068] In this way, by connecting the two flow paths 214a and 214b via the connector 130, the second connection flow path 214 can be formed and the second connection flow path 214 can be installed in the hepatic vein 13.

[0069] In the present embodiment, the connection port 120 is formed on the bottom surface of the chamber 100. In the open system circuit, the perfusion fluid is directly discharged from the hepatic vein 13 into the chamber 100. At this time, when the hepatic vein 13 protrudes upward compared to the water surface of the perfusion fluid, there is a problem of the perfusion fluid foaming. In the present embodiment, by forming the connection port 120 on the bottom surface of the chamber 100, it is possible to prevent air bubbles from invading the flow path from the connection port 120, and as a result, it is possible to prevent air bubbles from invading the liver 10.

[0070] Moreover, in the present embodiment, the connection port 120 is formed on the convex portion 140 provided at the bottom of the chamber 100. Thereby, it is possible to prevent the liver 10 from coming into contact with the connection port 120, and as a result, it is possible to prevent the liver 10 from being damaged due to the unevenness of the connection port 120, or to prevent the suction pressure from the first connection flow path 212 from being applied to the liver 10 in the case where the connection port 120 is blocked by the liver 10.

[0071] In addition, in the present embodiment, the flow path cross-sectional area A1 (refer to Figure 2 ) of the first connection flow path 212 for the open system circuit is larger than the flow path cross-sectional area A2 (refer to Figure 3 ) of the second connection flow path 214 for the closed system circuit. Therefore, the outer diameter a1 of the connection port 120 is larger than the outer diameter a2 of the connector 130. For example, the outer diameter a1 of the connection port 120 is 9 mm to 18 mm, and the outer diameter a2 of the connector 130 is 6 mm to 15 mm.

[0072] By increasing the flow path cross-sectional area of the first connection flow path 212, it is possible to reduce the pressure loss in the first connection flow path 212, and it is possible to efficiently transport the perfusion fluid in the chamber 100 to the liquid storage tank 400 using the atmospheric pressure of the perfusion fluid applied to the chamber 100.

[0073] [Control during use of the closed system circuit]

[0074] When the state of the liver 10 is not good, the liver 10 sometimes stores the perfusion fluid. In such a case, it is impossible to achieve the balance between the amount of the perfusion fluid delivered to the liver 10 and the amount of the perfusion fluid exiting from the liver 10, and there is a case where the perfusion fluid in the storage tank 400 decreases and worst-case becomes empty. If the pump 300 is driven in a state where there is no perfusion fluid in the storage tank 400, air will enter the liver 10.

[0075] In the case of forming an open system loop, it is possible to easily replenish the perfusion fluid from the upper part of the chamber 100, but in the case of forming a closed system loop, it is impossible to replenish the perfusion fluid from the chamber 100. In addition, since the storage tank 400 is also airtight, it is impossible to easily replenish the perfusion fluid. And, in the closed system loop, the total amount of the perfusion fluid flowing in the loop is smaller than this total amount in the open system loop, and thus the risk of the storage tank 400 becoming empty is higher than this risk in the open system loop.

[0076] The control device 500 according to the present embodiment monitors the liquid level height of the storage tank 400 through the liquid level sensor 410 in the case where a closed system loop is formed, and replenishes the perfusion fluid to the storage tank 400 in the case where the liquid level height of the storage tank 400 is lower than a predetermined threshold value.

[0077] Refer to Figure 6 to explain the replenishment method. Figure 6 is a flowchart showing the replenishment method. Figure 6 Each process (step) shown is a process executed by the control device 500, and is realized by the CPU 501 executing various programs stored in the storage device 503.

[0078] In addition, the control device 500 determines whether the formed loop is a closed system loop based on the information input from the input device 504. In the case where the control device 500 determines that the formed loop is not a closed system loop, in other words, in the case where it determines that it is an open system loop, it does not execute Figure 6 the process shown. In the case where the control device 500 determines that the formed loop is a closed system loop, it starts Figure 6 the process shown. In addition, the control device 500 can also automatically detect the formed loop. For example, it may be that a detector capable of detecting whether the flow path is connected to each of the connectors 401 and 402 is provided, and the control device 500 detects the formed loop based on the detection result of this detector. In addition, the control device 500 can also start Figure 6 the process shown in the case where an open system loop is formed.

[0079] In step S1, the control device 500 determines whether the liquid level height of the storage tank 400 is lower than a predetermined first threshold value H1 based on the measurement result of the liquid level sensor 410.

[0080] When it is determined that the liquid level height of the liquid storage tank 400 is not less than the first threshold value H1 (being "No" in step S1), in other words, when it is determined that the liquid level height of the liquid storage tank 400 is above the first threshold value H1, the control device 500 causes the process to proceed to step S3. When it is determined that the liquid level height of the liquid storage tank 400 is lower than the first threshold value H1 (being "Yes" in step S1), the control device 500 causes the process to proceed to step S2.

[0081] In step S2, the control device 500 opens the replenishment valve 232. Thereby, the perfusion liquid is replenished from the infusion bag 234 containing the perfusion liquid toward the liquid storage tank 400 through the replenishment flow path 230. In addition, the infusion bag 234 is arranged, for example, above the liquid storage tank 400 in the vertical direction. Thereby, the perfusion liquid flows from 234 toward the liquid storage tank 400 due to gravity.

[0082] In step S3, the control device 500 determines whether the liquid level height of the liquid storage tank 400 is above a predetermined second threshold value H2 based on the measurement result of the liquid level sensor 410. The second threshold value H2 is set to a value larger than the first threshold value H1.

[0083] When it is determined that the liquid level height of the liquid storage tank 400 is not above the second threshold value H2 (being "No" in step S3), in other words, when it is determined that the liquid level height of the liquid storage tank 400 is less than the second threshold value H2, the control device 500 ends the process. When it is determined that the liquid level height of the liquid storage tank 400 is above the second threshold value H2 (being "Yes" in step S3), the control device 500 causes the process to proceed to step S4.

[0084] In step S4, the control device 500 closes the replenishment valve 232 to end the process. Thereby, the replenishment of the perfusion liquid from 234 to the liquid storage tank 400 is stopped.

[0085] The control device 500 executes the Figure 6 process shown at a predetermined cycle. Thereby, the liquid level height of the perfusion liquid in the liquid storage tank 400 is maintained above the first threshold value H1. As a result, it is possible to prevent the inside of the liquid storage tank 400 from becoming empty and air from being delivered to the liver 10. In addition, the liquid level height of the perfusion liquid in the liquid storage tank 400 is maintained to be less than the second threshold value H2. As a result, the total amount of the perfusion liquid used in the closed loop can be controlled within a predetermined range.

[0086] [Modification Example]

[0087] In the above-described embodiment, it is assumed that the organ is the liver 10. Since the liver 10 has two inlet blood vessels, the organ perfusion device 1 is provided with a first inflow passage 222 and a second inflow passage 224 as the inflow passage 220. In addition, when an organ having only one inlet blood vessel is targeted, the organ perfusion device 1 is provided with one inflow passage, and when an organ having three inlet blood vessels is targeted, the organ perfusion device 1 is provided with three inflow passages. That is, it is only necessary to set the inflow passage according to the number of inlet blood vessels of the targeted organ.

[0088] In addition, when an organ having two outlet blood vessels is targeted, the organ perfusion device 1 only needs to be provided with two second connection passages 214 for the closed system circuit. That is, it is only necessary to set the outflow passage (connection passage) for the closed system circuit according to the number of outlet blood vessels of the targeted organ.

[0089] In the above-described embodiment, it is assumed that the organ perfusion device 1 is provided with a first pump 310 for flowing the perfusion liquid through the first inflow passage 222, and a second pump 320 for flowing the perfusion liquid through the second inflow passage 224. In addition, the organ perfusion device 1 may also implement the functions of the first pump 310 and the second pump 320 by one pump.

[0090] In the above-described embodiment, it is assumed that the organ perfusion device 1 is provided with a liquid storage tank 400. In addition, the organ perfusion device 1 may not be provided with the liquid storage tank 400. In this case, it is only necessary to connect the outflow passage 210 and the inflow passage 220 via one passage. Any device or the like may also be provided between the outflow passage 210 and the inflow passage 220, as long as the outflow passage 210 and the inflow passage 220 are fluidly connected.

[0091] In the above-described embodiment, it is assumed that in order to increase the flow passage cross-sectional area of the passage connected to the connection port 120, the organ perfusion device 1 forms a connector 401 and a connector 402 in the liquid storage tank 400 and separately uses the first connection passage 212 and the second connection passage 214 according to the circuit. In addition, when the flow passage cross-sectional area of the passage connected to the connection port 120 is the same as that of the passage connected to the hepatic vein 13, it is not necessary to separately use the passage according to the circuit, and the connector on the outflow passage 210 side formed in the liquid storage tank 400 may also be one. In other words, in the above-described embodiment, the outflow passage 210 only needs to have a structure capable of selectively connecting to either the connection port 120 or the outlet blood vessel, and may also be composed of one connection passage.

[0092] In the above-described embodiment, it is assumed that the liquid storage tank 400 has at least five connectors. In addition, the liquid storage tank 400 only needs to have at least a connector for connecting the outflow passage 210 and the inflow passage 220, and only needs to have two or more connectors. The number of connectors provided in the liquid storage tank 400 only needs to be set according to the number of passages that may be connected to the liquid storage tank 400, and is not limited to five.

[0093] [Mode]

[0094] Those skilled in the art understand that the above-described embodiment is a specific example of the following mode.

[0095] (First item) An organ perfusion device according to one mode is an organ perfusion device for perfusing a perfusion liquid into an organ. The organ perfusion device includes: a chamber that is open to the atmosphere and is used to accommodate the organ; an inflow passage that is connected to the inlet blood vessel of the organ; and one or more outflow passages that are fluidly connected to the inflow passage and are arranged on the outlet blood vessel side of the organ. The chamber includes a connection port that is configured to be able to be opened and closed and is configured to be able to be connected to one or more outflow passages. The one or more outflow passages are configured to be able to selectively connect to either the connection port or the outlet blood vessel. In the organ perfusion device, an open-system circuit is formed by connecting the one or more outflow passages to the connection port, and a closed-system circuit is formed by connecting the one or more outflow passages to the outlet blood vessel.

[0096] According to the organ perfusion device described in the first item, the user of the organ perfusion device can arbitrarily select an open-system circuit and a closed-system circuit.

[0097] (Second item) In the organ perfusion device described in the first item, the connection port is formed at the bottom of the chamber.

[0098] According to the organ perfusion device described in the second item, in the case where an open-system circuit is formed, even if the perfusion liquid foams when the perfusion liquid discharged from the outlet blood vessel is directly discharged into the chamber, it is possible to prevent bubbles from invading the passage from the connection port. As a result, it is possible to prevent bubbles from invading the organ.

[0099] (Third item) In the organ perfusion device described in the second item, the chamber includes a convex portion that is formed on the bottom surface and protrudes toward the outside of the chamber opposite to the side that receives the organ. The connection port is formed on the convex portion.

[0100] According to the organ perfusion device described in the third item, it is possible to prevent damage to the organ due to unevenness of the connection port, etc., or to prevent the suction pressure from the inflow passage from being applied to the organ in the case where the connection port is blocked by the organ.

[0101] (Fourth) The organ perfusion device according to any one of the first to third items further includes a liquid storage tank that stores the perfusion liquid. One or more outflow flow paths include: a first flow path that is connected to the liquid storage tank and selectively connected to the connection port to form an open system circuit; and a second flow path that is connected to the liquid storage tank and selectively connected to the outlet blood vessel to form a closed system circuit. The flow path cross-sectional area of the first connection flow path is larger than that of the second connection flow path.

[0102] According to the organ perfusion device described in the fourth item, by increasing the flow path cross-sectional area of the first connection flow path, the pressure loss can be reduced. In the case where an open system circuit is formed, the perfusion liquid in the chamber can be efficiently transported to the liquid storage tank by using the atmospheric pressure of the perfusion liquid applied to the chamber.

[0103] (Fifth) The organ perfusion device described in the fourth item further includes: a replenishment flow path that is connected to the liquid storage tank and is used to receive the perfusion liquid replenished to the liquid storage tank; a valve that opens and closes the replenishment flow path; a liquid level sensor that measures the liquid level height of the perfusion liquid in the liquid storage tank; and a control device. When the liquid level height is less than the first threshold value, the control device performs replenishment control to open the valve to replenish the perfusion liquid to the liquid storage tank.

[0104] According to the organ perfusion device described in the fifth item, it is possible to prevent the liquid storage tank from becoming empty and air from being transported to the organ.

[0105] (Sixth) In the organ perfusion device described in the fifth item, when a closed system circuit is formed, the control device performs replenishment control.

[0106] According to the organ perfusion device described in the sixth item, replenishment control is performed in a closed system circuit where the total amount of the perfusion liquid flowing through the circuit is less than that of the open system circuit and the risk of the liquid storage tank becoming empty is higher than that of the open system circuit. Therefore, the risk of the liquid storage tank becoming empty can be reduced.

[0107] It should be considered that the embodiments disclosed this time are illustrative in all aspects and not restrictive. The scope of the present invention is shown not by the description of the above embodiments but by the claims, and is intended to include all changes within the meaning and scope equivalent to the claims.

[0108] Explanation of reference numerals

[0109] 1: Organ perfusion device; 10: Liver; 11: Hepatic artery; 12: Portal vein; 13: Hepatic vein; 14: Bile duct; 100: Chamber; 102: Opening; 120: Connection port; 120a, 401a, 402a: Cover; 122: Waste liquid port; 130, 401 - 405: Connector; 132: First connection part; 134: Second connection part; 140: Protrusion; 210: Outflow path; 212: First connection flow path; 214: Second connection flow path; 220: Inflow path; 222: First inflow path; 224: Second inflow path; 230: Supplementary flow path; 232: Supplementary valve; 234: Infusion bag; 240: Waste liquid flow path; 242: Waste liquid valve; 250: Bile flow path; 252: Container; 300: Pump; 310: First pump; 320: Second pump; 400: Liquid storage tank; 410: Liquid level sensor; 500: Control device; 503: Storage device; 504: Input device; 600: Supply device; 610: First supply device; 620: Second supply device; 700: Flowmeter; 710: First flowmeter; 720: Second flowmeter; 800: Pressure gauge; 810: First pressure gauge; 820: Second pressure gauge.

Claims

1. An organ perfusion device for perfusing a perfusion fluid into an organ, the organ perfusion device comprising: a chamber that is open to the atmosphere and is for accommodating the organ; an inflow passage that is connected to the inlet blood vessel of the organ; and one or more outflow passages that are fluidly connected to the inflow passage and are disposed on the outlet blood vessel side of the organ, Among them, the chamber includes a connection port that is configured to be openable and closable and is configured to be connectable to the one or more outflow passages, the one or more outflow passages are configured to be selectively connectable to either the connection port or the outlet blood vessel, an open system circuit is formed by connecting the one or more outflow passages to the connection port, a closed system circuit is formed by connecting the one or more outflow passages to the outlet blood vessel.

2. The organ perfusion device according to claim 1, wherein the connection port is formed at the bottom of the chamber.

3. The organ perfusion device according to claim 2, wherein the chamber includes a convex portion that is formed on the bottom surface and protrudes toward the outside of the chamber opposite to the side for receiving the organ, the connection port is formed in the convex portion.

4. The organ perfusion device according to claim 1, wherein it further comprises a liquid storage tank that stores the perfusion fluid, the one or more outflow passages include: a first passage that is connected to the liquid storage tank and is selectively connectable to the connection port to form the open system circuit; and a second passage that is connected to the liquid storage tank and is selectively connectable to the outlet blood vessel to form the closed system circuit, the flow cross-sectional area of the first passage is larger than the flow cross-sectional area of the second passage.

5. The organ perfusion device according to claim 4, wherein, It further comprises: a replenishment passage that is connected to the liquid storage tank and is for receiving the perfusion fluid replenished to the liquid storage tank; a valve that opens and closes the replenishment passage; a liquid level sensor that measures the liquid level height of the perfusion fluid in the liquid storage tank; and a control device, when the liquid level height is less than a first threshold value, the control device performs replenishment control of opening the valve to replenish the perfusion fluid to the liquid storage tank.

6. The organ perfusion device according to claim 5, wherein when the closed system circuit is formed, the control device performs the replenishment control.

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