Auxiliary treatment paste for gout and preparation method thereof

Abstract

The invention relates to the technical field of gout ointment, and particularly discloses gout adjuvant therapy ointment and a preparation method thereof.The gout adjuvant therapy ointment is prepared from, by mass, 20-30 parts of sunflower heads, 10-15 parts of lilies, 3-5 parts of Japanese chilies, 15-20 parts of clausena lansium, 8-12 parts of folium isatidis, 30-40 parts of honey and 15-20 parts of rock candy. According to the treatment ointment, natural plants such as sunflower discs, lilies, Japanese peppers, clausena lansium and folium isatidis serve as main raw materials, and compared with traditional gout treatment drugs, the treatment ointment has the advantages that the symptoms of gout are relieved, and meanwhile side effects on the body are greatly reduced. The invention provides a safer adjuvant therapy choice for gout patients, and is especially suitable for patients who cannot tolerate the side effects of traditional drugs or have poor compliance to drug treatment.

Description

Technical Field

[0001] The present invention belongs to the technical field of gout plasters, and particularly relates to a gout adjuvant therapy plaster and a preparation method thereof. Background Art

[0002] Gout is a common and complex type of arthritis, mainly caused by the deposition of monosodium urate crystals in joints, triggering an inflammatory response. Its clinical symptoms include joint pain, swelling, and deformity, seriously affecting the quality of life of patients. With the changes in people's lifestyles and eating habits, the incidence of gout shows an increasing trend year by year, bringing a heavy burden to patients and the social medical system.

[0003] Currently, the conventional treatment methods for gout mainly rely on drugs, such as colchicine, non-steroidal anti-inflammatory drugs, and urate-lowering drugs. Although these drugs can relieve symptoms and control the condition to a certain extent, long-term use is often accompanied by many side effects. For example, colchicine may cause gastrointestinal reactions such as nausea, vomiting, and diarrhea, and some urate-lowering drugs may damage liver and kidney functions. In addition, some patients have poor compliance with drug treatment, resulting in recurrence of the condition. Therefore, finding safe and effective gout adjuvant treatment methods or products has become a research hotspot in the medical field and the health industry.

[0004] In traditional medicine, many natural plants have been found to have potential medicinal values. Sunflower disk contains active ingredients such as alkaloids, flavonoids, and protein small peptides, which can specifically bind to uric acid, form a complex and be excreted through metabolism, thereby reducing the blood uric acid level. It can also dissolve gouty tophi, and has anti-inflammatory, swelling-reducing, and pain-relieving effects; Lily can not only moisten the lungs and relieve cough, soothe the nerves, but also has a certain immunomodulatory effect, helping to enhance the body's resistance and assisting the body in coping with gout and its complications; Wild pepper (Chinese prickly ash) is rich in various nutrients and has the effects of improving immunity, antibacterial and anti-inflammatory, which is beneficial to improving the physical condition of gout patients; Wampee contains rich acidic substances, phenols, amino acids, etc., which can aid digestion, resolve phlegm, relieve asthma, and improve immunity, and can help patients improve digestive function and enhance physical fitness during the treatment of gout; Folium Isatidis, as a classic heat-clearing and detoxifying drug, can cool the blood and eliminate macules, and has a certain relieving effect on symptoms such as fever and inflammation accompanied by acute gout attacks.

[0005] However, at present, there are few examples on the market of scientifically formulating these natural plants into gout adjuvant treatment products. The existing gout adjuvant treatment products lack systematicness in formula design and cannot fully exert the synergistic effects of various plant components. Summary of the Invention

[0006] The purpose of the present invention is to provide a gout adjuvant therapy plaster and a preparation method thereof to solve the problems raised in the above background art.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A gout adjuvant treatment paste, the treatment paste comprising the following raw materials in parts by mass: 20-30 parts of sunflower disc, 10-15 parts of lily, 3-5 parts of mountain pepper, 15-20 parts of wampee, 8-12 parts of folium isatidis, 30-40 parts of honey, and 15-20 parts of rock sugar.

[0009] Preferably, the treatment paste comprises the following raw materials in parts by mass: 20 parts of sunflower disc, 10 parts of lily, 3 parts of mountain pepper, 15 parts of wampee, 8 parts of folium isatidis, 30 parts of honey, and 15 parts of rock sugar.

[0010] A preparation method of a gout adjuvant treatment paste, comprising the following steps:

[0011] S1. Material pretreatment

[0012] Wash the sunflower disc, remove impurities, cut it into pieces, and soak it in clean water for 2 hours;

[0013] Break the lily into petals, rinse it with clean water, and remove the surface impurities and remaining outer skin;

[0014] Select the bad seeds and impurities from the mountain pepper (Chinese prickly ash), quickly rinse it with clean water, and drain the water;

[0015] Wash the wampee, remove the fruit stones, and cut the pulp into pieces for later use;

[0016] Wash the folium isatidis, remove the yellow leaves and impurities, and cut it into small sections;

[0017] S2. Extract the active ingredients

[0018] Water extraction: Put the pretreated sunflower disc, lily, wampee, and folium isatidis into an extraction tank, add 10 times the amount of water (calculated based on the total weight of the raw materials), soak for 30 minutes, then heat to boiling, and keep it in a slightly boiling state for extraction for 2 hours. After the extraction is completed, filter while it is hot, and collect the filtrate.

[0019] Secondary water extraction: Add 8 times the amount of water to the extraction tank, repeat the above extraction process for 1.5 hours, filter, and combine the two filtrates;

[0020] Chinese prickly ash oil extraction: Extract Chinese prickly ash oil from the mountain pepper (Chinese prickly ash) by steam distillation method. Put the Chinese prickly ash into a distillation device, add water, heat and distill, collect the distilled oil-water mixture, and separate the Chinese prickly ash oil through a separatory funnel for later use;

[0021] S3. Concentrate the filtrate

[0022] Transfer the combined filtrate to a concentration pot, and concentrate it under reduced pressure at 60-70 °C until the volume of the filtrate is reduced to about 1 / 3 of the original volume to obtain a concentrated solution;

[0023] S4. Boil the paste

[0024] Add rock sugar to the concentrated liquid and continue heating and stirring until the rock sugar is completely dissolved;

[0025] Add honey, stir, keep heating on low heat, and keep stirring to prevent the paste from sticking to the pan and burning;

[0026] Slowly drip the extracted prickly ash oil while stirring to evenly disperse the prickly ash oil in the paste;

[0027] Keep boiling, and constantly skim off the surface foam during this period until the paste becomes thick. When dipping the paste with chopsticks and the paste can hang on the chopsticks and flow down in a line, stop heating;

[0028] S5. Quality inspection and packaging

[0029] Conduct inspections on indicators such as the appearance, properties, relative density, and microbial limit of the boiled paste to ensure compliance with relevant quality standards. The appearance should be brownish-brown to dark brown, with a uniform and delicate texture; the relative density should meet the specified range; the microbial limit should comply with the national food safety standards.

[0030] After the paste cools to room temperature, use a sterile filling device to fill the paste into sterilized glass bottles and seal them for storage.

[0031] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0032] The present invention takes sunflower disk as the core ingredient. The alkaloids, flavonoids, protein small molecule peptides, etc. contained in it can specifically bind to uric acid to form a complex and be excreted from the body, effectively reducing the blood uric acid level. At the same time, it can also dissolve gouty tophi and play the effects of anti-inflammatory, detumescence, and pain relief. Lily can soothe the nerves, regulate the body functions, enhance the body's immunity, assist the body in coping with gout and its complications, and relieve the anxiety, insomnia, etc. caused by the disease in patients. Prickly ash (Sichuan pepper) helps prevent joint infections and other problems in gout patients by enhancing immunity, antibacterial, and anti-inflammatory effects. Wampee helps patients improve digestive function and enhance physical fitness by promoting digestion and enhancing immunity, providing support for the body's recovery. The heat-clearing and detoxifying, cooling blood and removing macules properties of Isatis indigotica Fort. play a good role in relieving the inflammation and fever symptoms during the acute attack of gout. These ingredients cooperate with each other to comprehensively condition gout symptoms from multiple angles and relieve the pain of patients.

[0033] At the same time, the treatment paste of the present invention uses natural plants such as sunflower disk, lily, prickly ash, wampee, and Isatis indigotica Fort. as the main raw materials. Compared with traditional gout treatment drugs, while reducing gout symptoms, it greatly reduces the side effects on the body. It provides a safer adjuvant treatment option for gout patients, especially suitable for those who cannot tolerate the side effects of traditional drugs or have poor compliance with drug treatment.

[0034] The formula of the present invention has a wide range of applications: whether it is during the acute attack of gout, when patients experience symptoms such as joint swelling, heat and pain, fever, etc., or during the remission period of gout, when it is necessary to control uric acid levels, prevent gout attacks, and regulate body functions, this treatment cream can play an auxiliary therapeutic role. It can be used as a supplementary means of daily treatment for gout patients, combined with traditional drugs to enhance the therapeutic effect; it can also be used as a separate auxiliary conditioning product to help patients improve their physical condition and improve their quality of life. DETAILED DESCRIPTION

[0035] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0036] Embodiment 1:

[0037] A method for preparing a gout auxiliary treatment ointment comprises the following steps:

[0038] 1. Prepare the raw materials

[0039] Accurately weigh 25kg of sunflower discs, 12kg of lilies, 4kg of peppercorns, 18kg of yellow peel, 10kg of isatis indigo leaves, 35kg of honey, and 18kg of rock sugar.

[0040] 2. Material Pretreatment

[0041] Sunflower disk treatment: Use professional cleaning equipment, high-pressure spray cleaning machine, to rinse the sunflower disk at a water pressure of 0.3MPa to remove surface dust and impurities. After rinsing, use a vegetable cutter to cut into small pieces with a side length of about 1-2cm, put them in a stainless steel soaking pool, add clean water to completely immerse the sunflower disk pieces, and soak for 2 hours.

[0042] Lily processing: Wash the lilies in a drum-type washing machine at a speed of 20r / min to remove impurities and residual skin. After washing, break them into petals manually and rinse them again with clean water.

[0043] Processing of Sichuan pepper: Use a vibrating screening machine to screen the Sichuan pepper to remove bad seeds and impurities, then quickly rinse with clean water, place on a stainless steel drying tray to drain the water, place the drying tray in a well-ventilated drying room, keep the indoor temperature at 25°C, and control the humidity at 50% RH, and dry it in the sun for 2-3 hours.

[0044] Kumquat processing: After the kumquat is cleaned by a fruit and vegetable cleaning machine, the core is removed by a core remover, and then the flesh is cut into 0.5-1cm cubes by a fruit cutter for later use.

[0045] Treatment of Folium Isatidis: Wash Folium Isatidis with a chain-type washing machine to remove yellow leaves and impurities, and then cut it into small pieces of 2 - 3 cm with a forage cutter.

[0046] III. Extracting Active Ingredients

[0047] Water extraction: Put the pretreated sunflower discs, lilies, wampee fruits, and Folium Isatidis into a 500L multi-functional extraction tank, add 10 times the amount of purified water (calculated based on the total weight of the raw materials), turn on the stirring device, set the stirring speed to 60 r / min, and soak for 30 minutes. After soaking, heat with steam to raise the temperature in the extraction tank to 100 °C within 30 minutes, and maintain a slightly boiling state for extraction for 2 hours. After extraction, use a centrifugal pump to filter the extract through a 200-mesh filter screen into a temporary storage tank, and collect the filtrate.

[0048] Secondary water extraction: Add 8 times the amount of purified water to the extraction tank, repeat the above extraction process for 1.5 hours, control the extraction temperature at 95 - 100 °C, and the stirring speed at 50 r / min. After extraction, filter again, and combine the two filtrates into a concentration tank.

[0049] Extraction of prickly ash oil: Put the drained wild pepper (prickly ash) into a 50L steam distillation device, add 30L of clear water, turn on the steam heating, keep the pressure in the distillation device at 0.1 - 0.15 MPa, the temperature at 100 - 105 °C, and the distillation time at 3 - 4 hours. Collect the distilled oil-water mixture, separate the prickly ash oil through an oil-water separator, and transfer it to a brown glass bottle for sealed storage.

[0050] IV. Concentrating the Filtrate

[0051] Transfer the combined filtrate to a 200L vacuum concentration pot, turn on the vacuum pump to maintain the pressure in the pot at -0.08 - -0.09 MPa, control the temperature at 65 °C, and conduct vacuum concentration. During the concentration process, observe the relative density of the concentrated solution. When the relative density reaches 1.15 - 1.20 (20 °C), stop the concentration to obtain the concentrated solution.

[0052] V. Boiling the Paste

[0053] Pour the concentrated solution into a 200L stainless steel boiling pot, add the weighed rock sugar, turn on the stirring device, set the stirring speed to 40 r / min, and slowly heat to 80 - 90 °C to completely dissolve the rock sugar.

[0054] Add honey, continue to stir evenly, keep heating with a low flame, control the temperature at 70 - 80 °C, and the stirring speed at 30 r / min to prevent the paste from sticking to the pot and burning.

[0055] Slowly drip the extracted prickly ash oil, controlling the dripping speed at 3 - 5 drops per second, and stir while dripping to ensure that the prickly ash oil is evenly dispersed in the paste.

[0056] Keep boiling over low heat, and constantly skim off the foam generated on the surface of the paste with a stainless - steel skimmer during this period. When dipping the paste with a glass rod, the paste can hang on the glass rod and flow down in a line, with the line length about 2 - 3 cm, then stop heating.

[0057] VI. Quality Inspection and Packaging

[0058] Quality Inspection

[0059] Appearance and properties: Randomly select 10 bottles of paste and observe under natural light. The paste should be brownish - black to black - brown, with uniform and delicate texture, and no visible impurities to the naked eye.

[0060] Relative density: Measure with a densitometer at 20°C, and the relative density should not be less than 1.30 (20°C).

[0061] Microbial limit: Detect according to the microbial limit inspection method of the Chinese Pharmacopoeia. The number of bacteria per gram of paste shall not exceed 1000 cfu, the number of molds and yeasts shall not exceed 100 cfu, and no pathogenic bacteria such as Escherichia coli and Staphylococcus aureus shall be detected.

[0062] Packaging: After the paste cools to room temperature, perform aseptic filling with an automatic filling machine. The filling accuracy of the filling machine is controlled within ±1 g. Fill the paste into 200 - g sterilized brown glass bottles, then use a capping machine to seal the bottle caps, affix product labels, and store in the warehouse.

[0063] Example 2:

[0064] I. Prepare raw materials

[0065] Prepare 250 g of sunflower plates, 120 g of lilies, 40 g of wild peppers (prickly ash), 180 g of wampee, 100 g of folium isatidis, 350 g of honey, and 180 g of rock sugar.

[0066] II. Material pretreatment

[0067] Sunflower plate treatment: Rinse the sunflower plates with clean water to remove the dust and impurities on the surface, and cut them into small pieces. Find a clean basin, put the sunflower plate pieces into it and add clean water, soak for 2 hours to make them fully absorb water and become soft.

[0068] Lily treatment: Break the lilies into petals one by one, carefully rinse them under running water to remove the impurities and remaining outer skins on the surface, and ensure the cleanliness of the lily petals.

[0069] Wild pepper (prickly ash) treatment: Put the wild pepper (prickly ash) on the chopping board, pick out the bad seeds and impurities, then quickly rinse it with clean water, and place it in a ventilated place to dry the moisture.

[0070] Processing of wampee: After washing the wampee with clean water, remove the fruit stones by hand or with a small knife, and then cut the pulp into small pieces for later use.

[0071] Processing of isatis leaf: Rinse the isatis leaf in clean water to remove the yellow leaves and impurities, and then cut it into small sections with a knife.

[0072] III. Extracting active ingredients

[0073] Water extraction: Put the processed sunflower trays, lilies, wampees, and isatis leaves into a large stainless-steel pot, add 10 times the amount of water (about 5 - 6 liters), stir well and soak for 30 minutes. After the soaking is over, cover the pot lid, turn on high heat to bring the water to a boil, and then turn to low heat to keep it boiling gently for 2 hours. During the boiling process, stir occasionally to prevent sticking to the bottom of the pot. After boiling, filter while it is hot with a strainer, and pour the filtrate into a clean basin.

[0074] Secondary water extraction: Add 8 times the amount of water (about 4 - 5 liters) to the raw materials that have been boiled just now, repeat the above heating process, and boil gently for 1.5 hours on low heat. After boiling, filter again, and combine the two filtrates together.

[0075] Extraction of prickly ash oil: Find a small pot with a lid, put the wild pepper (prickly ash) in it, add an appropriate amount of water (just enough to cover the prickly ash), cover the pot lid, and turn on low heat to cook slowly. After cooking for a while, you will see a layer of oil floating on the water surface. Prepare a small bowl, place a strainer on the bowl, and slowly pour the water for cooking the prickly ash into the strainer, leaving the oil floating in the bowl to separate the prickly ash oil, and set it aside for later use.

[0076] IV. Concentrating the filtrate

[0077] Pour the combined filtrate into a stainless-steel pot, turn on low heat to cook slowly, and let the water evaporate slowly. Keep stirring constantly during the cooking process to prevent burning at the bottom. Cook until the volume of the filtrate is reduced to about 1 / 3 of the original, becoming a relatively thick liquid, and thus obtain the concentrated liquid.

[0078] V. Boiling to make paste

[0079] Add rock sugar to the concentrated liquid, continue to heat on low heat, and stir constantly with a spoon until the rock sugar is completely dissolved.

[0080] Add honey, stir well, keep on low heat, and keep stirring to avoid the paste sticking to the pot.

[0081] Dip a chopstick into a little of the previously separated prickly ash oil, slowly drip it into the pot, and stir while dripping to evenly disperse the prickly ash oil in the paste.

[0082] Simmer over low heat continuously. When there are foams on the surface of the paste, skim them off with a spoon. When dipping the paste with chopsticks, if the paste can stick to the chopsticks and drips in a line, it means it is cooked well, then stop heating.

[0083] VI. Quality Inspection and Preservation

[0084] Quality Inspection: Observe the cooked paste. Under normal circumstances, the paste should be brownish - black to black - brown in color, with uniform texture, no obvious particles and impurities. After the paste cools down, take a little to taste. The taste should be sweet with a special fragrance of Chinese prickly ash, without any strange smell.

[0085] Preservation: Prepare a clean glass bottle without water and oil, preferably with a sealed lid. After the paste has completely cooled down, put the paste into the glass bottle, tighten the lid, and store it in a cool and dry place. Every time when taking it, use a clean spoon without water to avoid contaminating the paste.

[0086] In summary, the present invention processes traditional Chinese medicinal materials into a paste. Because of its spiciness, it can be eaten simultaneously with meals. At the same time, it maintains the physical properties of traditional Chinese medicinal materials. After combination, the atoms and molecules of each medicinal material can play the greatest role in the human body, accelerating the decomposition, disappearance and excretion of acid - base salt stones in the bodies of gout patients.

[0087] Application Principle. The following is the principle of material combination and the basic medicinal effects of the present invention:

[0088] I. The anti - gout effect of sunflower disk is reflected in the following aspects:

[0089] 1. Lowering blood uric acid: Active ingredients in sunflower disk, such as alkaloids, flavonoids, protein small - molecule peptides, etc., can specifically bind to uric acid to form a sunflower - alkali uric - acid complex, which is excreted from the body through the metabolism of the liver and then through the kidneys, thus quickly reducing the uric acid level.

[0090] 2. Dissolving gout stones: As an enzyme preparation that can be directly absorbed by the intestine, small - molecule peptides can enter the blood to regulate uric acid metabolism and renal tubular transport proteins, control uric acid production, and increase the excretion amount of uric acid, which helps to dissolve the already formed gout stones.

[0091] 3. Anti - inflammatory, detumescence and pain relief: The flavonoid components in sunflower disk can inhibit the chemotaxis of inflammatory cells and reduce the release of inflammatory factors, and have a unique anti - inflammatory, detumescence and pain - relief effect on acute gouty arthritis.

[0092] 4. Clearing heat and cooling blood, and soothing the liver to relieve pain: Sunflower disk is cold in nature and enters the meridian of liver and blood aspect, which can clear heat and cool blood, and is often used to treat dysmenorrhea in women. Sunflower disk enters the liver meridian, can soothe the liver to relieve pain and clear heat, and can treat dizziness, headache, hypertension, blurred vision, etc. caused by hyperactivity of liver - yang.

[0093] It should be noted that although sunflower heads have the above-mentioned anti-gout effects, they are not the first choice for treating gout. Gout patients should use drugs such as colchicine and ibuprofen sustained-release capsules under the guidance of a doctor, and pay attention to dietary regulation and improvement of living habits.

[0094] II. Efficacy and functions of lilies

[0095] 1. Moistening the lungs and relieving cough

[0096] Sweet, cool and moistening, mainly entering the lung and heart meridians, it is good at clearing the lung and moistening dryness to relieve cough, clearing the heart and calming the mind to relieve uneasiness. It is used to treat dry cough due to dryness-heat in lung yin deficiency, chronic cough due to lung deficiency, blood in phlegm, hemoptysis due to consumptive disease, etc., and is commonly used for dry cough due to lung dryness and restlessness of the heart.

[0097] 2. Calming the mind and soothing the nerves

[0098] Lily enters the heart meridian and is slightly cold in nature. It can clear away heart-fire and relieve restlessness, calm the mind and soothe the nerves. It is used for symptoms such as remaining fever after febrile diseases, absent-mindedness, insomnia and dreaminess, depression, and crying easily due to grief.

[0099] 3. Beautifying the face and nourishing the skin

[0100] Lilies are white and delicate. Fresh lilies are rich in mucilage and vitamins, which are beneficial to the metabolism of skin cells. Regular consumption of lilies has a certain beauty effect.

[0101] 4. Preventing and treating cancer

[0102] Lily contains a variety of alkaloids, which can prevent leukopenia, increase blood cells, and has a therapeutic effect on cytopenia after chemotherapy and radiotherapy. Lily can also promote and enhance the mononuclear cell system and phagocytic function in the body, and improve the body's humoral immune ability. Therefore, lily has a good preventive and therapeutic effect on various cancers.

[0103] III. The efficacy and functions of mountain pepper mainly include the following aspects:

[0104] Supplementing nutrition: Mountain pepper contains rich nutritional components such as vitamin C, vitamin B1, carotene, dietary fiber, etc. Appropriate consumption can supplement the nutrients required by the human body.

[0105] Promoting digestion: The dietary fiber in mountain pepper can promote gastrointestinal peristalsis, which is beneficial to the digestion and absorption of food.

[0106] Increasing appetite: Mountain pepper has a special aroma, which can increase appetite and improve the situation of loss of appetite.

[0107] Assisting in protecting the eyes: Vitamin A in mountain pepper can promote the development of the optic nerve in the eyes and improve eyesight.

[0108] Antioxidation: Nutrients such as vitamin C and vitamin E in mountain pepper can scavenge free radicals in the body, help reduce the appearance of wrinkles, and achieve the effect of antioxidation.

[0109] Weight loss: Capsaicin can stimulate the brain to release endorphins, relieve pain, and speed up metabolism, keeping people slim.

[0110] Lowering blood pressure and lipid: It can reduce the levels of cholesterol, low-density lipoprotein, and triglycerides, promote blood circulation, and prevent diseases such as heart disease and stroke.

[0111] Strengthening the spleen and promoting digestion: Capsicum contains capsaicin and crude fiber, which can stimulate the secretion of saliva and gastric juice, strengthen the spleen and stomach, and promote appetite.

[0112] Other effects: Eliminating stomach cold; Capsicum has a significant effect on preventing colds, arteriosclerosis, night blindness, and scurvy.

[0113] Warming the middle-jiao and relieving pain: Mountain pepper can be used to treat symptoms such as stomach cold vomiting, abdominal pain and diarrhea, playing the role of warming the middle-jiao and relieving pain.

[0114] Insecticidal and antipruritic: Mountain pepper has a certain insecticidal effect, can be used to treat diseases such as ascariasis, hookworm disease, and pinworm disease, and can relieve symptoms such as skin itching

[0115] Regulating qi and promoting digestion: Mountain pepper helps to promote gastrointestinal peristalsis, accelerate food digestion, and relieve symptoms such as food retention and qi stagnation, abdominal distension and pain, and loss of appetite.

[0116] Expelling cold and relieving pain: Mountain pepper is warm in nature, can expel cold and relieve pain, and improve discomfort symptoms such as abdominal cold pain, diarrhea, and joint pain.

[0117] Relieving cough and asthma: Mountain pepper also has the effect of relieving cough and asthma, and can assist in the treatment of diseases such as bronchial asthma and cough.

[0118] Antibacterial and anti-inflammatory: The volatile oil and capsaicin in mountain pepper have strong antibacterial and anti-inflammatory effects, and can prevent and treat diseases such as gastrointestinal infections.

[0119] Enhancing immunity: Multiple nutrients and active substances in mountain pepper can enhance immunity and strengthen the body's resistance.

[0120] IV. Wampee is a fruit rich in nutrients and high in medicinal value. The following are the main functions and effects of wampee:

[0121] 1. Nutrient supplementation: Wampee fruits contain a large number of essential nutrients for the human body, such as water, protein, fat, crude fiber, carbohydrates, etc.

[0122] 2. Promote digestion: Wampee fruits contain a large amount of acidic substances, such as ascorbic acid and various amino acids, which can increase the acidity of human gastric juice and help digest food.

[0123] 3. Reduce phlegm and relieve asthma: Wampee fruits contain wampiocinnamide A, B, C, D, as well as phenols, various amino acids, flavonoid glycosides, etc. They can not only regulate qi movement but also astringe the lung qi. At the same time, they can also relieve the spasm of smooth muscles, playing a role in reducing phlegm and relieving asthma.

[0124] 4. Promote digestion and regulate qi: The main effects of wampee are to promote qi movement to relieve stagnation, relieve exterior syndrome and disperse heat, and can also relieve pain and reduce phlegm. Clinically, it can treat stomachache, abdominal pain, cold, fever, etc.

[0125] 5. Clear summer heat: The main effects of wampee are to promote qi movement to relieve stagnation, relieve exterior syndrome and disperse heat, and can also relieve pain and reduce phlegm. Clinically, it can treat stomachache, abdominal pain, cold, fever, etc.

[0126] 6. Aid digestion and strengthen the spleen: Wampee fruits help strengthen the spleen and aid digestion. There is a folk saying: "Eat lychees when hungry, eat wampees when full", indicating that people in ancient times had already discovered that wampees are helpful for digestion and strengthening the spleen.

[0127] 7. Enhance immunity: Wampee fruits help enhance human immunity.

[0128] 8. Relieve cough and reduce phlegm: Wampee fruits contain wampiocinnamide and phenols, various amino acids, etc., which help astringe the lung qi and relieve the spasm of smooth muscles, having the effect of reducing phlegm and relieving asthma.

[0129] 9. Relieve summer heat and promote fluid production: Wampee fruits help relieve summer heat and promote fluid production.

[0130] 10. Promote fluid production and quench thirst: Wampee fruits pickled with rock sugar have a good effect of promoting fluid production and quenching thirst. For thirst, dry mouth, and throat discomfort caused by reduced body fluids, eating wampee fruits pickled with rock sugar can significantly promote the production of saliva in the mouth and relieve thirst and dry mouth.

[0131] 11. Relieve fatigue and restore physical strength: Boiling wampee fruits with rock sugar can supplement the body with rich carbohydrates, that is, sugars. These sugars can well replenish the glycogen in muscles. For some laborers, especially manual laborers, if they appropriately consume wampee fruits boiled with rock sugar, they can relieve fatigue and restore physical strength by supplementing glycogen.

[0132] 12. Strengthen the spleen and stomach: Traditional Chinese medicine believes that sweetness can well improve the function of the spleen and stomach, and wampee fruits boiled with rock sugar taste sweet, which can promote the transportation and transformation function of the spleen and stomach and improve the digestive ability.

[0133] 13. Strengthen the heart and relax the tension of chest and abdominal muscles: Modern research shows that wampee can stimulate bile secretion, promote digestion, enhance the absorption function, and also has the effects of strengthening the heart, relaxing the tension of chest and abdominal muscles, and reducing or eliminating distension.

[0134] 14. Diuretic and detumescence, promoting qi and relieving pain: The pericarp and seed of wampee are also excellent medicinal materials, with the effects of diuretic and detumescence, promoting qi and relieving pain, etc.

[0135] V. The functions and effects of folium isatidis

[0136] Folium isatidis is a very classic drug for clearing heat and detoxifying. This drug is bitter and cold, and belongs to the heart meridian and stomach meridian. It can purge the fire of the heart meridian and stomach meridian, and is used for high fever. We call it heat entering nutrient blood, with symptoms such as spots, rashes, and bleeding points on the body. It can cool blood and eliminate spots, and is used to treat high fever diseases. In addition, the bitter cold property of folium isatidis can treat jaundice, that is, damp-heat in the liver and gallbladder, and can also treat dysentery. It can also treat epidemic parotitis, formerly known as mumps, and can also treat the swelling and pain of the throat wall and pharynx, because folium isatidis belongs to the stomach meridian. In addition, it can also treat erysipelas, that is, streptococcal infection, and various carbuncles and boils. Generally, folium isatidis plays the role of clearing heat and detoxifying, cooling blood and eliminating spots.

[0137] It should be understood that in the development process of any actual implementation, such as in any engineering or design project, a large number of specific implementation decisions can be made. Such development efforts may be complex and time-consuming, but for those ordinary technical personnel who benefit from this disclosure, without excessive experimentation, the development efforts will be a routine work of design, manufacturing and production.

[0138] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not restrictive. Although the present invention has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention, and they should all be covered by the scope of the claims of the present invention.

Claims

1. A gout adjuvant therapy paste, characterized in that, The therapeutic paste comprises the following raw materials in parts by mass: 20-30 parts of sunflower disc, 10-15 parts of lily, 3-5 parts of mountain pepper, 15-20 parts of wampee, 8-12 parts of folium isatidis, 30-40 parts of honey, and 15-20 parts of rock sugar.

2. The adjuvant therapeutic plaster for gout according to claim 1, wherein: The therapeutic paste comprises the following raw materials in parts by mass: 20 parts of sunflower disc, 10 parts of lily, 3 parts of mountain pepper, 15 parts of wampee, 8 parts of folium isatidis, 30 parts of honey, and 15 parts of rock sugar.

3. The preparation method of a gout adjuvant therapy paste according to any one of claims 1-2, characterized in that: It includes the following steps: S1. Material pretreatment Wash the sunflower disc, remove impurities, cut it into pieces, and soak it in clean water for 2 hours; Break the lily into petals, rinse it with clean water, and remove the surface impurities and remaining outer skin; Select the bad seeds and impurities from the mountain pepper (Chinese prickly ash), quickly rinse it with clean water, and drain the water; Wash the wampee, remove the fruit stones, and cut the pulp into pieces for standby; Wash the folium isatidis, remove the yellow leaves and impurities, and cut it into small sections; S2. Extract the active ingredients Water extraction: Put the pretreated sunflower disc, lily, wampee, and folium isatidis into an extraction tank, add 10 times the amount of water (calculated based on the total weight of the raw materials), soak for 30 minutes, then heat to boiling, and keep it boiling gently for extraction for 2 hours. After the extraction is completed, filter while it is hot, and collect the filtrate; Secondary water extraction: Add 8 times the amount of water to the extraction tank, repeat the above extraction process for 1.5 hours, filter, and combine the two filtrates; Extraction of Chinese prickly ash oil: Extract Chinese prickly ash oil from the mountain pepper (Chinese prickly ash) by steam distillation method. Put the Chinese prickly ash into a distillation device, add water, heat and distill, collect the distilled oil-water mixture, and separate the Chinese prickly ash oil through a separating funnel for standby; S3. Concentrate the filtrate Transfer the combined filtrate to a concentration pot, and concentrate it under reduced pressure at 60-70 °C until the volume of the filtrate is reduced to about 1 / 3 of the original, obtaining a concentrated solution; S4. Boil the paste Add rock sugar to the concentrated solution, continue to heat and stir until the rock sugar is completely dissolved; Add honey, stir, keep heating with a low flame, and keep stirring to prevent the paste from sticking to the pan and burning; Slowly drip the extracted Chinese prickly ash oil, stir while adding, and make the Chinese prickly ash oil evenly dispersed in the paste; Continue to boil, constantly skimming off the surface foam during this period, until the paste becomes thick. When dipping the paste with chopsticks and the paste can hang on the chopsticks and flow down in a line, stop heating; S5. Quality inspection and packaging Conduct inspections on the indexes such as appearance, properties, relative density, and microbial limit of the boiled paste to ensure compliance with relevant quality standards. The appearance should be brownish-brown to dark brown, with uniform and delicate texture; the relative density should meet the specified range; the microbial limit should comply with the national food safety standard; After the paste is cooled to room temperature, use a sterile filling device to fill the paste into sterilized glass bottles and seal them for storage.