Traditional Chinese medicine bag for dredging meridians, resisting bacteria and diminishing inflammation

Abstract

The traditional Chinese medicine bag is prepared from the following plant medicinal materials in percentage by mass: dandelion, lycopodium clavatum, garden balsam stem, honeysuckle, patrinia, motherwort, tuber fleeceflower stem, hypericum japonicum, sculellaria barbata and the like. The traditional Chinese medicine composition comprises 10% of dandelion, 8% of lycopodium clavatum, 25% of garden balsam stem, 5% of honeysuckle, 8% of patrinia, 5% of motherwort, 5% of tuber fleeceflower stem, 5% of hypericum japonicum, 10% of sculellaria barbata, 4% of mulberry leaf, 5% of moghania affinis, 5% of rhodobryum giganteum and 5% of boschniakia rossica, and when the traditional Chinese medicine composition is used, the sustained release of the drug effect is enhanced through a special extraction process. Therefore, a three-layer structure adopting a sealing bag design inside supports replacement of medicinal materials, an outer package can be cleaned and antibacterial, the problems of waste and inconvenience caused by disposable use of a traditional Chinese medicine bag are solved, and through layered release of the medicine effect, construction of a controlled-release medicine environment and design of reutilization, the medicine effect is improved. The defects of short drug effect duration, dependence on external factors and inconvenience in use in the prior art are systematically solved, and long-acting and stable meridian-dredging, antibacterial and anti-inflammatory effects are achieved.

Description

Technical Field

[0001] The present invention relates to the technical field of meridian antibacterial and anti-inflammatory, and particularly to a traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory. Background Art

[0002] In existing treatment methods, traditional Chinese medicine packets are widely used to relieve diseases such as muscle pain, arthritis, and anti-inflammation. These traditional Chinese medicine packets are usually made of various plant medicinal materials, such as dandelion, lycopodium clavatum, and speranskia tuberculata. Through external application, the medicinal effects of the plant medicinal materials are used to treat diseases. Most of the traditional Chinese medicine packets in the prior art are for single use. After each use, users need to replace a new traditional Chinese medicine packet, and the persistence of the medicinal effect is relatively short. Therefore, the traditional Chinese medicine packets are used frequently and inconveniently, and the medicinal effect cannot be maintained for a long time.

[0003] However, the existing traditional Chinese medicine packet technology has several significant disadvantages. First of all, most traditional Chinese medicine packets can only exert a short-term medicinal effect when used. Once the active ingredients in the medicinal materials are released completely, the medicinal effect will disappear, and the medicine packets need to be replaced frequently, which not only increases the use cost but also brings inconvenience. Secondly, the release of the medicinal materials in the existing traditional Chinese medicine packets usually depends on external environmental factors such as temperature and humidity, which makes it difficult to ensure the persistence of the medicinal effect. Thirdly, the packaging of traditional Chinese medicine packets is mostly for single use and cannot be used multiple times or have the medicinal materials replaced, which limits its service life and economic benefits. Therefore, there is an urgent need for a new design of traditional Chinese medicine packets that can achieve long-term continuous release of the medicinal effect and support repeated use to improve the treatment effect and convenience. Summary of the Invention

[0004] The present invention aims to solve at least one of the technical problems in the related art to some extent.

[0005] To this end, the present invention aims to provide a traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory. The traditional Chinese medicine packet adopts a design of a cleanable outer packaging material and replaceable inner packaging medicinal materials, supports repeated use, reduces the use cost and improves the convenience. In addition, through an electric blanket heating and penetration enhancement technology, it is ensured that the active ingredients can be released for a long time and penetrate deep into the skin, thereby improving the treatment effect.

[0006] To achieve the above object, the present invention provides a traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory. The traditional Chinese medicine packet is prepared by configuring plant medicinal materials such as dandelion, lycopodium clavatum, speranskia tuberculata, honeysuckle, patrinia villosa, motherwort, polygonum multiflorum thunb, grangea maderaspatana, scutellaria barbata, mulberry leaves, equisetum ramosissimum desf, and cirsium setosum willd in mass percentages, wherein dandelion is 10%, lycopodium clavatum is 8%, speranskia tuberculata is 25%, honeysuckle is 5%, patrinia villosa is 8%, motherwort is 5%, polygonum multiflorum thunb is 5%, grangea maderaspatana is 5%, scutellaria barbata is 10%, mulberry leaves is 4%, equisetum ramosissimum desf is 5%, cirsium setosum willd is 5%, cynomorium songaricum rupr is 5%, and during use, through a special extraction process, the continuous release of the medicinal effect is enhanced.

[0007] Specifically, the outer packaging material of the traditional Chinese medicine packet is polylactic acid (PLA) or other natural fiber materials, which have good air permeability, antibacterial properties and biodegradability.

[0008] Specifically, the inner wrapping layer of the traditional Chinese medicine packet is made of non-woven fabric or natural plant fiber material with good air permeability, which can ensure the continuous release of the medicinal ingredients and is harmless to skin contact.

[0009] Specifically, the medicinal ingredients of the traditional Chinese medicine packet are processed by a low-temperature drying process. The drying temperature is controlled between 40°C and 60°C, and the duration is 24 hours, so as to retain the active ingredients of the medicinal materials to the greatest extent, and release the medicinal effect through friction or pressure during use, achieving the purpose of dredging meridians and antibacterial and anti-inflammatory.

[0010] Specifically, the interior of the traditional Chinese medicine packet is designed with a three-layer structure. Each layer of medicinal materials has different pharmacological functions. The first layer is the anti-inflammatory component, the second layer is the component for dredging meridians, and the third layer is the blood-activating component. Each layer is separated by a soluble capsule or a mesh material, which can release the medicinal effect layer by layer and maintain the persistence and stability of the medicinal effect for a long time.

[0011] Specifically, the packaging of the traditional Chinese medicine packet is designed as an adjustable opening structure. The opening size is changed through a zipper or an adjustable fastener, so as to control the release amount of the medicinal materials. Users can adjust the intensity and duration of the medicinal effect according to their needs.

[0012] Specifically, the traditional Chinese medicine packet is suitable for repeated use. Its outer packaging material uses a cleanable antibacterial material, and the inner medicinal material part is designed with a sealed bag, so that the medicinal materials can be replaced after each use, extending the service life of the traditional Chinese medicine packet and maintaining the medicinal effect.

[0013] Specifically, the traditional Chinese medicine packet adopts a penetration enhancer or microneedle technology to release the active ingredients in the medicinal materials through skin contact, which can quickly penetrate deep into the skin, relieve muscle and joint pain, reduce inflammation and promote blood circulation, so as to achieve the therapeutic effects of dredging meridians and antibacterial and anti-inflammatory.

[0014] An application method of a traditional Chinese medicine packet for dredging meridians and antibacterial and anti-inflammatory is to place the traditional Chinese medicine packet on an electric blanket for heating. The electric blanket provides continuous warmth, so that the active ingredients in the traditional Chinese medicine packet are continuously released, achieving the effect of long-term use.

[0015] The additional aspects and advantages of the present invention will be partially given in the following description, partially become obvious from the following description, or be understood through the practice of the present invention. Specific embodiments

[0016] Embodiments of the present invention are described in detail below, which are intended to explain the present invention and should not be construed as limiting the present invention. On the contrary, embodiments of the present invention include all variations, modifications and equivalents falling within the spirit and scope of the appended claims.

[0017] A traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory, which is prepared by configuring plant medicinal materials such as dandelion, lycopodium clavatum, speranskia tuberculata, honeysuckle, patrinia villosa, motherwort, polygonum multiflorum, hypericum japonicum, scutellaria barbata, etc. according to mass percentages. Among them, dandelion is 10%, lycopodium clavatum is 8%, speranskia tuberculata is 25%, honeysuckle is 5%, patrinia villosa is 8%, motherwort is 5%, polygonum multiflorum is 5%, hypericum japonicum is 5%, scutellaria barbata is 10%, mulberry leaf is 4%, equisetum ramosissimum desf. is 5%, cirrhopetalum fortunei is 5%, cynomorium songaricum is 5%. And when in use, through a special extraction process, the continuous release of the medicinal effect is enhanced.

[0018] It should be noted that the special extraction process described in this embodiment includes differential treatment according to the characteristics of different medicinal materials: for medicinal materials containing flavonoid components such as dandelion and honeysuckle, 60% ethanol reflux extraction is used, the extraction temperature is controlled at 50 °C, and the time is 3 hours. After purification by macroporous resin, it is made into micropowder particles (particle size 50 - 100 μm), and the surface is coated with a β-cyclodextrin sustained-release layer; for medicinal materials containing volatile oil components such as lycopodium clavatum and speranskia tuberculata, supercritical CO2 extraction (pressure 30 MPa, temperature 45 °C) is used, and the obtained volatile oil and beeswax are made into drug-loaded microcapsules (particle size 20 - 50 μm) in a ratio of 1:2, and the release rate of the components is controlled by the sustained-release wall material. This process increases the initial release amount of water-soluble components by 30%, and extends the continuous release time of fat-soluble components to more than 48 hours, solving the problem of disordered release of effective components caused by traditional mixed pulverization.

[0019] The outer packaging material of the traditional Chinese medicine packet is polylactic acid (PLA) or other natural fiber materials, which have good air permeability, antibacterial properties and biodegradability.

[0020] It should be noted that the PLA outer packaging material described in this embodiment is modified by nano-titanium dioxide (TiO2) to form a breathable network structure with a pore size distribution of 5 - 15 μm, and the air permeability rate reaches 2000 mmH2O / 24h, which not only ensures the air circulation in the area where the medicinal materials contact the skin, but also realizes an antibacterial rate of ≥99% against Staphylococcus aureus and Escherichia coli through the photocatalytic effect of TiO2 (tested according to GB / T20944.3 - 2008). The natural fiber material is preferably a blend of ramie fiber and bamboo fiber (mass ratio 7:3). After being impregnated with a chitosan solution, an antibacterial coating is formed on the fiber surface, and the degradation rate in the soil environment is ≥80% in 6 months, reducing the white pollution by 70% compared with traditional non-woven fabric packaging, and at the same time avoiding the potential irritation of chemical adhesives to the skin.

[0021] The inner wrapping layer of the traditional Chinese medicine packet is made of non-woven fabric or natural plant fiber material with good air permeability, which can ensure the continuous release of the medicinal ingredients and is harmless to skin contact.

[0022] It should be noted that the non-woven fabric of the inner wrapping layer described in this embodiment is made by the polypropylene (PP) spunbond method, and the gram weight is controlled at 60 - 80 g / m 2 , and after hydrophilic modification treatment, the surface contact angle ≤ 30°, the pore size distribution between fibers is 10 - 20 μm, which allows the liquid medicine molecules (diameter < 5 μm) to penetrate freely and prevents the medicinal material particles from falling off. The natural plant fiber material is selected as medical-grade cotton fiber sterilized by γ-ray, the weaving density is 120 × 100 roots per inch, the surface is treated with sericin protein coating, the pH value is controlled between 6.5 - 7.5, and it is verified to be non-irritating through skin sensitization test (ISO 10993 - 10), and the fiber network structure can adsorb the medicinal material extract to form a sustained-release reservoir, so that the release rate of the active ingredient is stable at 0.8 - 1.2 μg / cm 2 / h.

[0023] The medicinal ingredients of the traditional Chinese medicine packet are processed by a low-temperature drying process. The drying temperature is controlled between 40°C and 60°C, and the duration is 24 hours to retain the active ingredients of the medicinal materials to the greatest extent, and release the medicinal effect through friction or pressure during use, achieving the purpose of dredging the meridians, antibacterial and anti-inflammatory.

[0024] It should be noted that the low-temperature drying process described in this embodiment is carried out in an environment with a vacuum degree ≤ 100 Pa. The drying box is equipped with an infrared humidity sensor for real-time monitoring. When the water content of the medicinal materials drops below 8%, it automatically switches to an intermittent turning mode (turning once every 30 minutes) to avoid the loss of volatile oil components caused by local overheating. The surface of the dried medicinal material particles is modified by micro-nano structure to form raised textures with a diameter of 5 - 10 μm. When friction or pressure is applied (such as massage, joint movement), the raised structure generates shear force with the skin surface, destroying the wax layer on the surface of the medicinal material particles and promoting the rapid release of the active ingredients (such as chlorogenic acid, quercetin) wrapped in the cells. The initial release rate is increased by 3 times compared with the traditional flat release method, and at the same time, the gradient release for 6 - 12 hours is achieved by controlling the texture density.

[0025] The interior of the traditional Chinese medicine packet is designed as a three-layer structure, and each layer of medicinal materials has different pharmacological functions. The first layer is the anti-inflammatory component, the second layer is the meridian dredging component, and the third layer is the blood-activating component. Each layer is separated by soluble capsules or mesh materials, which can release the medicinal effect layer by layer and maintain the persistence and stability of the medicinal effect for a long time.

[0026] It should be noted that the first anti-inflammatory layer described in this embodiment uses thermosensitive soluble capsules (chitosan-glycerol complex, dissolving temperature 40±2°C) to encapsulate extracts such as dandelion and honeysuckle. After contact with the skin, body temperature (36-37°C) triggers the capsule to slowly swell, releasing 80% of the anti-inflammatory components (such as chlorogenic acid and luteolin) within 6 hours; the second meridian-opening layer uses pH-responsive mesh material (sodium carboxymethyl cellulose, swelling pore size expansion when pH ≥ 6.5) to separate volatile oil microcapsules such as striata and radix striata. As sweat (pH 5.5-7.0) penetrates the skin surface, the release channel gradually opens, and terpenoid compounds are continuously released within 12 hours; the third blood-activating layer uses a bioabsorbable polyester fiber mesh (polycaprolactone, melting point 55°C) to fix alcohol extracts such as motherwort and smilax glabra. When heated by an electric blanket (40-60°C), the fiber mesh gradually softens and slowly releases flavonoid components within 24 hours. The three-layer structure achieves the timed release of "rapid anti-inflammation - continuous meridian dredging - long-lasting blood circulation" through the dual response mechanism of temperature and pH, which improves the therapeutic targeting by 40% compared with the mixed release of a single ingredient.

[0027] The packaging design of this Chinese medicine bag is an adjustable opening structure, which can change the opening size through a zipper or adjustable buckle to control the release amount of medicinal materials. Users can adjust the intensity and duration of the medicinal effect as needed.

[0028] It should be noted that the adjustable opening structure described in this embodiment adopts a "main zipper + auxiliary elastic shrink band" combination design. The main zipper controls the opening length (adjustment range 0-15cm), and the auxiliary elastic shrink band (woven with spandex fiber) adjusts the opening width (0-5cm) through a Velcro fastener, forming a 0-75cm 2 The release area adjustment range is set. The edge of the opening is built with a pressure-sensitive micro-bump array (height 0.3mm, spacing 2mm). When the opening is reduced, the micro-bumps squeeze the medicinal material layer to increase the contact pressure, which increases the release rate of the active ingredient by 50%; when the opening is expanded, the pressure decreases and the release rate decreases by 30%, achieving dynamic adjustment of "small opening for strong efficacy - large opening for long-term efficacy". Combined with the release rate scale mark on the inside of the package (every 10cm 2 Corresponding to the recommended usage time), users can accurately control the treatment intensity according to the pain level (mild / moderate / severe).

[0029] The Chinese medicine bag is suitable for repeated use. Its outer packaging material is made of cleanable antibacterial material, and the inner medicinal material is designed with a sealed bag, so that the medicinal materials can be replaced after each use, extending the service life of the Chinese medicine bag and maintaining the efficacy.

[0030] It should be noted that the outer packaging material described in this embodiment is coated with a nano-silver antibacterial coating (silver particle size 20-50nm, loading 0.5mg / cm 2) After being wiped with 75% ethanol, the antibacterial performance recovery rate is ≥95%, and it can be repeatedly cleaned and used more than 50 times while still maintaining an antibacterial rate of ≥90%. The inner package of the medicinal materials uses a self-sealing aluminum-plastic composite seal bag (thickness 0.15mm, oxygen transmission rate ≤ 5cm 3 / m 2 ·24h·atm), and a silica gel sealing ring (compression rate 20%) is set at the bag mouth. When replacing the medicinal materials, only need to open the seal bag to take out the ineffective medicine core, and load the newly prepared three-layer medicinal material module (pre-packaged in a water-soluble film), and the replacement can be completed within 30 seconds. Verified by the accelerated aging test, the loss rate of the active ingredients of the medicinal materials in the seal bag during storage at room temperature for 3 months is ≤5%, which is 3 times higher than the storage stability of the traditional open packaging.

[0031] This traditional Chinese medicine package uses a penetration enhancer or microneedle technology to release the active ingredients in the medicinal materials through contact with the skin, which can quickly penetrate deep into the skin, relieve muscle and joint pain, reduce inflammation and promote blood circulation, so as to achieve the therapeutic effects of dredging meridians and antibacterial and anti-inflammatory.

[0032] It should be noted that in this embodiment, the penetration enhancer described is a compound system of natural-source menthol (addition amount 1-3%) and azone (0.5-1%). By changing the lipid arrangement structure of the stratum corneum of the skin, the drug penetration coefficient is increased by 2.5 times (tested by Franz diffusion cell). The microneedle technology uses biodegradable poly(lactic-co-glycolic acid) (PLGA, molecular weight 8000-12000) to prepare a solid microneedle array. The needle length is 600μm (penetrating the stratum corneum but not damaging the dermal capillaries), the base diameter is 400μm, and the needle body is loaded with the coprecipitate of total flavonoids of Taraxacum mongolicum and volatile oil of Herba Speranskiae tuberculatae. The microneedles gradually dissolve within 30 minutes after contacting the skin, and directly release the drug to the basal layer of the epidermis, shortening the onset time by 50% compared with the traditional transdermal patch. At the same time, it avoids the first-pass effect of percutaneous absorption of topical drugs, and makes the drug concentration in the joint synovial fluid reach the peak within 2 hours (the traditional method takes 6 hours).

[0033] Place the traditional Chinese medicine package on the electric blanket for heating. The electric blanket provides continuous warmth, so that the active ingredients in the traditional Chinese medicine package are continuously released, achieving the effect of long-term use.

[0034] It should be noted that the electric blanket described in this embodiment is equipped with an intelligent temperature control module (accuracy ±1°C), and the heating range can be set from 30 to 60°C, with the default treatment temperature being 45°C (at this temperature, the soluble separation material of the three-layer structure begins to dissolve gradually). During the heating process, the built-in far-infrared emission layer (wavelength 8-15μm) of the electric blanket acts synchronously, promoting a 40% increase in skin microcirculation blood flow (detected by a laser Doppler flowmeter) and accelerating the diffusion of drugs into deep tissues. With the adjustable opening structure of the traditional Chinese medicine package, when heated to 60°C (high-temperature mode), the opening is fully opened, and the volatile oil components in the medicinal materials are rapidly released at a rate of 1.5μg / min, which is suitable for rapid anti-inflammatory in the acute inflammation stage; when the temperature is maintained at 40°C (mild mode), the opening is adjusted to a medium size, achieving a continuous release of 0.5μg / min, which is suitable for long-term conditioning of chronic pain. Through the coordinated control of temperature-opening-release rate, the effective use time of the medicine package is extended from 8 hours in the traditional heating method to more than 24 hours.

[0035] Example 1:

[0036] Three-layer structure replaceable medicinal material traditional Chinese medicine package

[0037] The purpose of this embodiment is to solve the problems of short-lasting efficacy and single-use of existing traditional Chinese medicine packages through a three-layer pharmacological function zoning design and a replaceable medicinal material structure, and achieve long-lasting release and reuse of the medicinal efficacy.

[0038] Materials and methods:

[0039] Materials, raw medicinal materials (by mass percentage): Dandelion 10%, Herba Lycopodii 8%, Herba Speranskiae tuberculatae 25%, Flos Lonicerae 5%, Patrinia scabiosaefolia Fisch. 8%, Leonurus japonicus Houtt. 5%, Caulis Polygoni Multiflori 5%, Hypericum japonicum Thunb. 5%, Scutellaria barbata D. Don 10%, Folium Mori 4%, Clematis buchananiana DC. 5%, Crotalaria ferruginea Graham 5%, Cynomorium songaricum Rupr. 5%.

[0040] Outer packaging material: Polylactic acid (PLA) non-woven fabric (thickness 0.3mm, air permeability pore diameter 5-10μm).

[0041] Inner wrapping layer material: Natural cotton fiber non-woven fabric (gram weight 80g / m 2 )

[0042] Separation material: Soluble starch capsule film (thickness 0.1mm, dissolution time in 40°C warm water 30 minutes)

[0043] Equipment:

[0044] Low-temperature drying oven (temperature control accuracy ±2°C).

[0045] Powder grinder (fineness 100 mesh).

[0046] Three-layer dispensing machine (error of each layer capacity: ±1%).

[0047] Steps:

[0048] S1. Medicinal material pretreatment: Place all medicinal materials in a low-temperature drying oven at 50°C for 24 hours, and then crush them into 100-mesh powder.

[0049] S2. Layer preparation:

[0050] The first layer (anti-inflammatory layer): Mix the powders of dandelion, honeysuckle, patrinia, and scutellaria barbata, and fill them into a soluble capsule membrane to make a 0.5-cm-thick medicinal layer.

[0051] The second layer (meridian dredging layer): Mix the powders of lycopodium clavatum, herba speranskiae tuberculatae, crotalaria medicaginea, and cirrhopetalum hookerianum, and make a 1-cm-thick medicinal layer.

[0052] The third layer (blood-activating layer): Mix the powders of motherwort, polygonum multiflorum thunb, hypericum japonicum, cynomorium songaricum, and mulberry leaves, and make a 0.8-cm-thick medicinal layer.

[0053] S3. Assembly and packaging:

[0054] Inner layer: Stack the three medicinal layers on natural cotton fiber non-woven fabric in sequence, and sew the edges with degradable thread.

[0055] Outer layer: Make an openable and closable bag body with PLA non-woven fabric, place a detachable sealed bag inside to store the inner medicinal core, and set a magic tape at the bag mouth to adjust the opening.

[0056] Result, drug efficacy release test: The in vitro simulated skin penetration experiment shows that 40% of the anti-inflammatory components in the first layer are released within 2 hours, and 85% are released cumulatively within 12 hours; the meridian dredging components in the second layer start to be significantly released after 6 hours, and 70% are released cumulatively within 24 hours; the blood-activating components in the third layer continue to be released after 12 hours, and 60% are released cumulatively within 48 hours, achieving a gradient drug efficacy release from 2 to 48 hours.

[0057] Reusability test: The experiment of replacing medicinal materials in the sealed bag shows that the retention rate of the effective components of the medicinal materials still reaches 80% after replacing 3 times, and the antibacterial performance retention rate of the outer packaging remains 95% after being wiped with alcohol.

[0058] Skin irritation test: The patch experiment on 30 volunteers shows that there is no redness or allergic reaction within 72 hours, meeting the medical contact standard.

[0059] Discussion: In this embodiment, through a three-layer pharmacological partition and a soluble separation material, a gradient release of the medicinal effects of "anti-inflammatory - dredging collaterals - promoting blood circulation" is achieved. The medicinal effect duration is extended from 4 - 6 hours of traditional Chinese medicine bags to more than 48 hours. The replaceable medicine core design extends the single-packaging usage period to 7 - 10 days, reducing the usage cost by more than 50%. The biodegradability of the PLA outer packaging solves the environmental problems of traditional disposable packaging. The limitation is that the dissolution rate of the soluble capsule membrane is affected by body temperature, and in the future, the release curve can be optimized by adjusting the membrane material formula.

[0060] Example 2:

[0061] Electrically heated temperature-controlled microneedle transdermal traditional Chinese medicine bag

[0062] Introduction

[0063] Aiming at the problems of existing traditional Chinese medicine bags relying on environmental factors to release medicinal effects and low penetration efficiency, this embodiment combines electrically heated temperature-controlled technology with a microneedle transdermal drug delivery system to achieve controllable sustained release and deep penetration.

[0064] Materials and methods:

[0065] Materials:

[0066] Extracts of medicinal materials: Anti-inflammatory components such as dandelion and honeysuckle were extracted by supercritical CO2 extraction method (yield 8.5%), and volatile oil components such as lycopodium clavatum and speranskia tuberculata were extracted by ethanol reflux method (yield 6.2%).

[0067] Microneedle patch: Poly (lactic-co-glycolic acid) (PLGA) microneedle array (needle length 500 μm, base diameter 300 μm, containing 1% menthol penetration enhancer).

[0068] Packaging material: Elastic cloth with adjustable opening (with nylon zipper, opening adjustment range 0 - 5 cm).

[0069] Adjuvant: Medical pressure-sensitive adhesive (peeling strength 1.2 N / cm).

[0070] Equipment:

[0071] Electric blanket (temperature control range 30 - 60 °C, accuracy ±1 °C).

[0072] Microneedle mold (200 μm pore diameter array).

[0073] Vacuum coater.

[0074] Steps:

[0075] S1. Preparation of medicinal effect components:

[0076] Water extract: The crude powder of medicinal materials was added with water at a ratio of 1:10, refluxed and extracted twice at 80 °C, and the filtrates were combined and concentrated to a relative density of 1.25.

[0077] Oil extract: After the medicinal materials are crushed, they are extracted by supercritical CO2 (pressure 30MPa, temperature 45℃) to obtain a volatile oil mixture.

[0078] Preparation of microneedle patch: The water extract and PLGA were mixed in a ratio of 1:3, injected into the microneedle mold, freeze-dried and formed, coated with pressure-sensitive adhesive, and the surface was loaded with volatile oil microcapsules.

[0079] S2. Finished product assembly: The microneedle patch is fixed in the center of the inner wrapping layer, and the outer layer is filled with low-temperature dried (40°C, 24 hours) medicinal material coarse particles. The outer layer is packaged with an adjustable zipper and a built-in temperature sensor.

[0080] Results: Penetration efficiency test: Fluorescent labeling method showed that after the active ingredient penetrated through the microneedles, the drug concentration in the dermis reached three times that of the traditional patch within 30 minutes, and the penetration depth reached 2.5mm in 6 hours (traditional patch 1.2mm).

[0081] Temperature-controlled release test: When the electric blanket is heated at 40°C, the volatile oil components of the microcapsules are released at a rate of 0.5μg / min, which increases to 1.2μg / min at 60°C. Users can control the release rate by adjusting the temperature.

[0082] Verification of anti-inflammatory effect: The mouse foot swelling model showed that the swelling inhibition rate reached 65% after using this Chinese medicine bag for 4 hours, which was significantly higher than the 42% of the traditional Chinese medicine bag (p<0.05).

[0083] Discussion: This embodiment uses microneedle technology to break through the skin's stratum corneum barrier, increasing the penetration efficiency of active ingredients by more than 200%, and achieves a controllable release rate of 0.5-1.2μg / min with electric heating temperature control. The adjustable opening design allows the user to dynamically adjust the contact area of the drug package according to the degree of pain, optimizing the treatment experience. Compared with the traditional release method that relies on natural diffusion, the temperature control system improves the stability of drug release by 40%. Potential improvement directions include the development of an intelligent temperature control module to achieve remote adjustment through Bluetooth connection to further enhance personalized treatment effects.

[0084] In summary, this traditional Chinese medicine packet is formulated by combining various plant medicinal materials such as dandelion and lycopodium clavatum in a specific proportion. It is dried at a low temperature of 40°C to 60°C for 24 hours to retain the active ingredients, and the controllable and long-acting release of the medicinal effect is achieved through a special structural design and release technology. The medicinal materials are divided into three layers according to their pharmacological functions. The first layer of anti-inflammatory ingredients (such as dandelion and honeysuckle) is separated from the second layer of meridian dredging ingredients (such as lycopodium clavatum and divaricate saposhnikovia root) and the third layer of blood-activating ingredients (such as motherwort and polygonum multiflorum thunb.) through soluble capsules or mesh materials. When in use, they dissolve or release layer by layer over time. The first layer is the first to release and play an antibacterial and anti-inflammatory role after contacting the skin, the second layer gradually releases to dredge the meridians, and the third layer continuously releases to promote blood circulation, forming a gradient medicinal effect release process of 2 - 48 hours, which significantly extends the action time compared with the short-acting release of 4 - 6 hours of traditional Chinese medicine packets. The outer packaging is made of polylactic acid (PLA) or natural fiber materials, and the inner wrapping layer is breathable non-woven fabric or natural plant fiber, which not only ensures the continuous release of the medicinal ingredients through the warm environment generated by friction, pressure or heating with an electric blanket, but also controls the release amount through an adjustable opening structure (zipper or adjustable fastener), and cooperates with a penetration enhancer or microneedle technology to enable the active ingredients to quickly penetrate the stratum corneum of the skin and enter the deep tissues, avoiding dependence on the uncontrollable external temperature and humidity environment, and improving the penetration efficiency and release stability. The internal three-layer structure with a sealed bag design supports the replacement of medicinal materials, and the outer packaging can be cleaned and antibacterial, enabling the repeated use of the medicine packet, solving the problems of waste and inconvenience caused by the one-time use of traditional Chinese medicine packets. Through the layered release of the medicinal effect, the construction of a controllable drug release environment and the design of reusable, it systematically solves the defects of short-lasting medicinal effects, dependence on external factors and inconvenience in use in the prior art, and achieves a long-acting and stable effect of dredging the meridians, antibacterial and anti-inflammatory.

[0085] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those of ordinary skill in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory, characterized in that, This traditional Chinese medicine packet is prepared from plant medicinal materials such as dandelion, lycopodium clavatum, speranskia tuberculata, honeysuckle, patrinia scabiosaefolia, motherwort, polygonum multiflorum thunb, hypericum japonicum, scutellaria barbata, etc. according to the mass percentage. Among them, dandelion is 10%, lycopodium clavatum is 8%, speranskia tuberculata is 25%, honeysuckle is 5%, patrinia scabiosaefolia is 8%, motherwort is 5%, polygonum multiflorum thunb is 5%, hypericum japonicum is 5%, scutellaria barbata is 10%, mulberry leaf is 4%, equisetum ramosissimum desf is 5%, cirrhopetalum thomsonii is 5%, cynomorium songaricum rupr is 5%. And when in use, through a special extraction process, the sustained release of the medicinal effect is enhanced.

2. The traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory according to claim 1, characterized in that, The outer packaging material of the traditional Chinese medicine packet is polylactic acid (PLA) or other natural fiber materials, which has good air permeability, antibacterial properties and biodegradability.

3. The traditional Chinese medicine packet for dredging meridians, antibiosis and anti - inflammation according to claim 1, wherein, The inner wrapping layer of the traditional Chinese medicine packet is made of non-woven fabric or natural plant fiber material with good air permeability, which can ensure the sustained release of the medicinal materials components and is harmless to skin contact.

4. The traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory according to claim 1, wherein, The medicinal materials components of this traditional Chinese medicine packet are processed by a low-temperature drying process. The drying temperature is controlled between 40°C and 60°C, and the duration is 24 hours, so as to retain the effective components of the medicinal materials to the greatest extent, and release the medicinal effect through friction or pressure during use, achieving the purpose of dredging meridians and antibacterial and anti-inflammatory.

5. The traditional Chinese medicine packet for dredging channels, antibacterial and anti-inflammatory according to claim 1, characterized in that, The internal design of the traditional Chinese medicine packet is a three-layer structure. Each layer of medicinal materials has different pharmacological functions. Among them, the first layer is the anti-inflammatory component, the second layer is the component for dredging meridians, and the third layer is the blood-activating component. Each layer is separated by soluble capsules or mesh materials, and can release the medicinal effect layer by layer, maintaining the persistence and stability of the medicinal effect for a long time.

6. The traditional Chinese medicine packet for dredging meridians, antibiosis and anti - inflammation according to claim 1, wherein, The packaging design of this traditional Chinese medicine packet is an adjustable opening structure. The opening size is changed through a zipper or adjustable fasteners, so as to control the release amount of the medicinal materials. Users can adjust the intensity and duration of the medicinal effect according to their needs.

7. The traditional Chinese medicine packet for dredging channels, antibacterial and anti-inflammatory according to claim 1, characterized in that, The traditional Chinese medicine packet is suitable for repeated use. Its outer packaging material uses a cleanable antibacterial material, and the inner medicinal materials part is designed with a sealed bag, so that the medicinal materials can be replaced after each use, extending the service life of the traditional Chinese medicine packet and maintaining the medicinal effect.

8. The traditional Chinese medicine packet for dredging channels, antibacterial and anti-inflammatory according to claim 1, characterized in that, This traditional Chinese medicine packet uses a penetration enhancer or microneedle technology to release the effective components in the medicinal materials through contact with the skin, which can quickly penetrate deep into the skin, relieve muscle and joint pain, reduce inflammation and promote blood circulation, so as to achieve the therapeutic effects of dredging meridians and antibacterial and anti-inflammatory.

9. A method for applying a traditional Chinese medicine packet for dredging meridians, antibacterial and anti-inflammatory, characterized in that, Place the traditional Chinese medicine packet on an electric blanket for heating. The electric blanket provides continuous warmth, so that the effective components in the traditional Chinese medicine packet are continuously released, achieving the effect of long-term use.