Preparation method of Chinese herbal medicine atomization physiotherapy fumigation bar

Abstract

The invention relates to the field of medicine fumigation nursing, in particular to a preparation method of a Chinese herbal medicine atomization physiotherapy fumigation stick, which comprises the following steps: S1, drying traditional Chinese medicine raw materials, and crushing to obtain traditional Chinese medicine raw material powder; s2, adding an adhesive, a smoke agent and water into the traditional Chinese medicine raw material powder, and uniformly stirring to obtain an intermediate state mixture; s3, inputting the mixture in the intermediate state in the step S2 into a screw extruder, extruding a fumigating rod prototype with an internal cavity by adopting an integral forming process, and sequentially performing drying treatment and slitting treatment on the extruded fumigating rod prototype to obtain a semi-finished product of the fumigating rod; s4, performing microwave puffing treatment on the semi-finished product of the fumigating rod to obtain a fumigating rod with pores; and S5, the water-soluble medicinal material extract particles and the oil-soluble medicinal liquid microencapsulated powder are sprayed on the fumigating rod to form a semi-closed structure, and when the water-soluble medicinal material extract particles and the oil-soluble medicinal liquid microencapsulated powder are burnt along with the fumigating rod, the fumigating rod has the medicinal liquid slow-release effect.

Description

Technical Field

[0001] The present invention relates to the field of fumigation nursing, and more specifically, to a preparation method of a traditional Chinese medicine atomizing physiotherapy fumigation stick. Background Art

[0002] Atomization therapy, also known as aerosol inhalation therapy, is a way of local treatment by converting drugs into fine atomized particles for patients to inhale. It has the following remarkable characteristics: 1. Acting directly on the respiratory tract: Atomization therapy can directly act on the respiratory tract and lungs through breathing, and can quickly play a role, especially for treating respiratory diseases such as asthma and bronchitis. 2. The drug can be quickly absorbed: Since the atomized particles are very small, they can quickly enter the lungs, and the absorption speed of the drug is relatively fast, and the onset is relatively fast. 3. Wide application range: The atomizer is easy to use and is suitable for children, the elderly, and patients who cannot take oral medications.

[0003] In atomization therapy, the commonly used medical atomizers in clinics mainly include compressed atomizers, ultrasonic atomizers, mesh atomizers, and spray atomizers. Their common feature is that they all use liquid medicaments as the atomization medium and add them to the atomizer. However, there may be a risk of leakage during the use of liquid medicaments. In addition, liquid medicaments usually need to be extracted, processed, and compounded from traditional Chinese herbal medicine raw materials. In this process, not only may their active ingredients be damaged, but also the processing cost will be increased.

[0004] The traditional Chinese herbal medicine fumigation method uses combustion for treatment, such as the "moxibustion" method of burning mugwort. However, since mugwort is compacted by a press and then wrapped and burned, during the burning process, incomplete combustion is likely to occur, resulting in residues and environmental pollution. Moreover, the compacted mugwort is not conducive to heat transfer and the volatilization and release of active ingredients, resulting in slow heat transfer and difficult volatilization and release of active ingredients.

[0005] Therefore, a traditional Chinese medicine atomizing physiotherapy fumigation stick that is convenient for heat transfer and the volatilization and release of active ingredients is exactly what people urgently need at present. Therefore, it is necessary to propose a preparation method of a traditional Chinese medicine atomizing physiotherapy fumigation stick to solve the above problems. Summary of the Invention

[0006] The present invention aims to overcome at least one defect (shortcoming) of the above-mentioned prior art, and provides a preparation method of a traditional Chinese medicine atomizing physiotherapy fumigation stick.

[0007] To solve the above technical problems, the technical solution of the present invention is as follows: A preparation method of a traditional Chinese medicine atomizing physiotherapy fumigation stick includes the following steps:

[0008] S1. Dry the Chinese herbal medicine raw materials and then pulverize them to obtain Chinese herbal medicine raw material powder;

[0009] S2. Add binder, fuming agent and water to the Chinese herbal medicine raw material powder, and stir evenly to obtain an intermediate mixture;

[0010] S3. Input the intermediate mixture in step S2 into a screw extruder, and use an integrated molding process to extrude a fumigation stick prototype with an internal cavity. Then, successively perform drying treatment and cutting treatment on the extruded fumigation stick prototype to obtain a semi-finished fumigation stick;

[0011] S4. Perform microwave puffing treatment on the semi-finished fumigation stick to obtain a fumigation stick with pores;

[0012] S5. Spray water-soluble Chinese herbal medicine extract particles and oil-soluble liquid medicine microencapsulated powder on the fumigation stick to form a semi-closed structure. When the water-soluble Chinese herbal medicine extract particles and oil-soluble liquid medicine microencapsulated powder burn along with the fumigation stick, the fumigation stick has a liquid medicine slow-release effect.

[0013] Furthermore, the following steps are also included in step S1:

[0014] S11. Select one or more combinations of Chinese herbal medicine raw materials and dry them;

[0015] S12. Use a crusher to crush the dried Chinese herbal medicine raw materials to obtain Chinese herbal medicine raw material powder with a mesh size of 80 - 100.

[0016] Even further, the following steps are also included in step S2:

[0017] S21. Mix one or more combinations of Chinese herbal medicine raw material powder evenly and pour it into a mixer;

[0018] S22. Pour binder, fuming agent and water into the mixer, and stir evenly with the Chinese herbal medicine raw material powder to obtain an intermediate mixture.

[0019] Furthermore, the following steps are also included in step S3:

[0020] S31. Set a cavity former for forming an internal cavity at the output end of the screw extruder, and input the intermediate mixture in step S2 into the screw extruder;

[0021] S32. Using an integrated molding process, the screw extruder extrudes the intermediate mixture to obtain a fumigation stick prototype with an internal cavity;

[0022] S32. Input the fumigation stick prototype into a dryer for drying treatment;

[0023] S33. Convey the fumigation stick prototype after drying treatment to the slitting mechanism for slitting to obtain semi-finished fumigation sticks.

[0024] Furthermore, the step S4 further includes the following steps:

[0025] S41. Control the microwave power of the microwave puffing machine at 300w - 1000w and put the semi-finished fumigation sticks into it.

[0026] S42. Heat the semi-finished fumigation sticks with the microwave puffing machine for 1 - 10 minutes so that after microwave puffing, the semi-finished fumigation sticks obtain fumigation sticks with pores on the surface.

[0027] Further, the step S5 further includes the following steps:

[0028] S51. Dissolve the water-soluble medicine in water to obtain an aqueous solution of the water-soluble medicinal material, and dissolve the β-cyclodextrin oil-soluble medicine in oil to obtain a mixed solution of β-cyclodextrin and oil.

[0029] S52. Convey the aqueous solution of the water-soluble medicinal material to a spray dryer and use the spray drying method to obtain water-soluble medicinal material extract particles. Convey the mixed solution of β-cyclodextrin and oil to a spray dryer and use the spray drying method to obtain oil-soluble liquid medicine microencapsulated powder.

[0030] S53. Spray the water-soluble medicinal material extract particles and the oil-soluble liquid medicine microencapsulated powder onto the fumigation sticks in sequence to form a semi-closed structure, so that when the fumigation sticks are lit, the water-soluble medicinal material extract particles and the oil-soluble liquid medicine microencapsulated powder have a slow-release effect during combustion.

[0031] Furthermore, the extrusion pressure of the screw extruder is controlled at 20 bar - 80 bar. The cross-section of the fumigation stick prototype is one of an annular shape, a pentagram shape, and a cross shape, and the wall thickness is 0.2 - 3 mm.

[0032] Further, the Chinese medicinal material raw material is one or a combination of more than one of Alstonia yunnanensis, Paris vietnamensis, Ardisia hanceana, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorus.

[0033] Furthermore, the binder is one or a combination of more than one of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan.

[0034] Further, the fuming agent is one or a combination of more than one of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate, or glyceryl caprylate.

[0035] Compared with the prior art, the beneficial effects of the technical solution of the present invention are:

[0036] The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick disclosed by the present invention follows the principles of traditional Chinese medicine. It uses a solid Chinese herbal medicine fumigation stick to replace the traditional liquid medicine as the atomizing matrix, and recombines the Chinese herbal medicine raw materials into a fumigation stick through an efficient and low-cost extrusion molding process. The active ingredients are more completely retained, not easily leaked, and convenient to carry. The produced fumigation stick is used in combination with the existing atomizing fumigation appliances on the market, and can accurately deliver the drug components to the upper respiratory tract and lungs, realizing stable release and efficient treatment, and having the potential to treat multiple diseases. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 is the flow chart of the preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick in the present invention.

[0038] Figure 2 is a schematic structural diagram of a Chinese herbal medicine atomizing physiotherapy fumigation stick;

[0039] Figure 3 is a schematic diagram of the pore structure and loaded liquid medicine of a Chinese herbal medicine atomizing physiotherapy fumigation stick;

[0040] Figure 4 is a microscopic morphology diagram of the pore structure of a Chinese herbal medicine atomizing physiotherapy fumigation stick;

[0041] Figure 5 (a) is a schematic diagram of the circular cross-section of the fumigation stick;

[0042] Figure 5 (b) is a schematic diagram of the pentagram cross-section of the fumigation stick;

[0043] Figure 5 (c) is a schematic diagram of the cross-shaped cross-section of the fumigation stick;

[0044] Figure 6 is a schematic diagram of the assembly effect of the fumigation stick, the adapted atomizing fumigation device and the filter device in Usage Scenario 1;

[0045] Figure 7 is a schematic diagram of the assembly effect of the fumigation stick, the adapted atomizing fumigation device and the filter device in Usage Scenario 2;

[0046] Figure 8 is a schematic diagram of the assembly effect of the fumigation stick, the adapted atomizing fumigation device and the filter device in Usage Scenario 3.

[0047] In the figures, 1 is the stick body of the fumigation stick, 1' is the internal cavity, 1" is the pore, 2 is the liquid medicine, 21 is the water-soluble medicinal material extract, 22 is the microencapsulated powder of the oil-soluble liquid medicine, 3 is the atomizing fumigation appliance, 4 is the feeding end, 5 is the suction end, 6 is the heating chamber, 7 is the filter device, 71 is the mouthpiece section, 72 is the base, 8 is the filtering section, and 9 is the cavity. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0048] The accompanying drawings are only for illustrative purposes and should not be construed as limiting the present patent. To better illustrate the embodiments, some components in the drawings may be omitted, enlarged or reduced, which do not represent the dimensions of the actual product. For those skilled in the art, it is understandable that some well-known structures and their descriptions in the drawings may be omitted.

[0049] In the description of the present invention, it should be noted that unless otherwise clearly specified and defined, the terms "installation" and "connection" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be directly connected or indirectly connected through an intermediate medium, and it can be said that the two components are internally connected. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances. The technical solutions of the present invention will be further described below with reference to the accompanying drawings and embodiments.

[0050] As Figure 1-8 shown, a preparation method of a traditional Chinese medicine atomization physiotherapy fumigation stick includes the following steps:

[0051] S1. Dry the traditional Chinese medicine raw materials and then perform a pulverization process to obtain traditional Chinese medicine raw material powder.

[0052] S2. Add an adhesive, a fuming agent, and water to the traditional Chinese medicine raw material powder, and stir evenly to obtain an intermediate state mixture.

[0053] S3. Input the intermediate state mixture in step S2 into a screw extruder, and use an integral molding process to extrude a fumigation stick prototype with an internal cavity, and successively perform a drying process and a cutting process on the extruded fumigation stick prototype to obtain a semi-finished fumigation stick.

[0054] S4. Perform a microwave puffing process on the semi-finished fumigation stick to obtain a fumigation stick with pores.

[0055] S5. Spray water-soluble traditional Chinese medicine extract particles and oil-soluble liquid medicine microencapsulation powder on the fumigation stick to form a semi-closed structure, so that the fumigation stick has a liquid medicine slow-release effect when the water-soluble traditional Chinese medicine extract particles and the oil-soluble liquid medicine microencapsulation powder burn along with the fumigation stick.

[0056] In the present invention, step S1 further includes the following steps:

[0057] S11. Select one or more combinations of traditional Chinese medicine raw materials and perform a drying process on them.

[0058] S12. Use a crusher to crush the dried traditional Chinese medicine raw materials to obtain traditional Chinese medicine raw material powder with a mesh size of 80-100.

[0059] In the present invention, step S2 further includes the following steps:

[0060] S21, After uniformly mixing the powders of one or more combined traditional Chinese medicine raw materials, pour them into a mixer.

[0061] S22, Pour the binder, fuming agent and water into the mixer, and stir evenly with the powders of traditional Chinese medicine raw materials to obtain an intermediate-state mixture.

[0062] In the present invention, step S3 further includes the following steps:

[0063] S31, Set a cavity former for forming an internal cavity at the output end of the screw extruder, and input the intermediate-state mixture in step S2 into the screw extruder.

[0064] S32, Adopt an integral molding process, and the screw extruder extrudes the intermediate-state mixture to obtain a fumigation rod prototype with an internal cavity.

[0065] S32, Input the fumigation rod prototype into a dryer for drying treatment.

[0066] S33, Transport the dried fumigation rod prototype to a slitting mechanism for slitting to obtain a semi-finished fumigation rod.

[0067] In the present invention, step S4 further includes the following steps:

[0068] S41, Control the microwave power of the microwave puffing machine at 300w - 1000w, and put the semi-finished fumigation rod into it.

[0069] S42, Use the microwave puffing machine to heat the semi-finished fumigation rod for 1 - 10 minutes, so that after the semi-finished fumigation rod is microwave-puffed, a fumigation rod with pores on the surface is obtained.

[0070] In the present invention, step S5 further includes the following steps:

[0071] S51, Dissolve the water-soluble drug in water to obtain an aqueous solution of the water-soluble traditional Chinese medicine, and dissolve the β-cyclodextrin oil-soluble drug in oil to obtain a mixed solution of β-cyclodextrin and oil.

[0072] S52, Transport the aqueous solution of the water-soluble traditional Chinese medicine to a spray dryer and use the spray drying method to obtain water-soluble traditional Chinese medicine extract particles, and transport the mixed solution of β-cyclodextrin and oil to a spray dryer and use the spray drying method to obtain oil-soluble medicament microencapsulation powder.

[0073] S53, Spray the water-soluble traditional Chinese medicine extract particles and the oil-soluble medicament microencapsulation powder onto the fumigation rod in sequence to form a semi-closed structure, so that when the fumigation rod is lit, the water-soluble traditional Chinese medicine extract particles and the oil-soluble medicament microencapsulation powder have a sustained-release effect during combustion.

[0074] In the present invention, the extrusion pressure of the screw extruder is controlled at 20 bar to 80 bar. The cross-section of the fumigation rod prototype is one of an annular shape, a pentagram shape, and a cross shape, and the wall thickness is 0.2 to 3 mm. The traditional Chinese medicine raw materials are one or a combination of several of Alstonia yunnanensis, Aristolochia kwangsiensis, Ardisia obovata, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorus. The binder is one or a combination of several of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan. The fumigant is one or a combination of several of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate, or glyceryl caprylocaprate. Specific Example 1

[0076] In this example, the traditional Chinese medicine atomizing physiotherapy fumigation rod produced by the method disclosed in the present invention includes a fumigation rod body 1, an internal cavity 1', and pores 1". The fumigation rod body 1 is cylindrical, with an outer diameter of 7.0 mm. The fumigation rod body 1 has an internal cavity 1' inside. The axis of the internal cavity 1' coincides with the axis of the fumigation rod body 1 and is located exactly in the middle of the cavity structure. The internal cavity 1' and the fumigation rod body 1 have the same length, both being 45 mm. The axial cross-section of the internal cavity 1' is annular, and the wall thickness is 0.2 mm.

[0077] The fumigation rod body 1 also has pores 1" with a pore size of 1 to 60 μm, which are arranged evenly in a honeycomb shape, facilitating heat transfer and the volatilization and release of active ingredients. At the same time, it can carry the liquid medicine 2, which matches the traditional Chinese medicine raw materials of the fumigation rod body, further enhancing the medicinal effect. Among them, the liquid medicine 2 includes directly added water-soluble medicinal extracts 21 and microencapsulated powders 22 of oil-soluble liquid medicine after embedding treatment. The microencapsulated powders 22 of oil-soluble liquid medicine are prepared by spray drying after mixing and dispersing β-cyclodextrin and the liquid medicine evenly, forming a semi-closed structure, enabling the liquid medicine to have a sustained-release effect.

[0078] The preparation method of the traditional Chinese medicine atomizing physiotherapy fumigation rod: Using traditional Chinese medicine raw materials, after drying and pulverizing, a certain amount of binder, fumigant, and water are added. After extrusion by a screw extruder, a semi-finished product is obtained through drying and cutting, and then a fumigation rod finished product with a porous structure is obtained after microwave puffing treatment. The extrusion pressure is between 20 bar, the microwave power is 600 w, and the treatment time is 2 minutes.

[0079] Among them, the traditional Chinese medicine raw materials are one or a combination of several of Alstonia yunnanensis, Aristolochia kwangsiensis, Ardisia obovata, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorus, and are powders with a mesh size of 80 - 100 after drying and crushing treatment. The raw materials have good medicinal effects and a high expansion rate. The binder is one or a combination of several of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan. The fumigant is one or a combination of several of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate, or glyceryl caprylocaprate. Specific Embodiment 2

[0081] In this embodiment, the Chinese herbal medicine atomizing physiotherapy fumigation stick produced by the method disclosed in the present invention includes a fumigation stick body 1, an internal cavity 1' and pores 1". The fumigation stick body 1 is cylindrical with an outer diameter of 6.5 mm. The fumigation stick body 1 has an internal cavity 1' inside. The axis of the internal cavity 1' coincides with the axis of the fumigation stick body 1 and is located exactly in the middle of the internal cavity 1'. The internal cavity 1' and the fumigation stick body 1 have the same length, both being 45 mm. The axial cross-section of the internal cavity 1' is an annular shape with a wall thickness of 2.0 mm.

[0082] The fumigation stick body 1 has pores 1" with a pore size of 1 - 80 μm, arranged in a honeycomb-like pattern evenly, facilitating heat transfer and the volatilization and release of active ingredients. At the same time, it can carry the liquid medicine 2, which matches the Chinese herbal medicine raw material of the fumigation stick body 1 to further enhance the medicinal effect.

[0083] Among them, the liquid medicine 2 includes directly added water-soluble medicinal material extracts 21 and microencapsulated powders 22 of oil-soluble liquid medicine after embedding treatment. The microencapsulated powders 22 of oil-soluble liquid medicine are prepared by spray drying after mixing β-cyclodextrin and the liquid medicine evenly, forming a semi-closed structure to make the liquid medicine have a slow-release effect.

[0084] The preparation method of this Chinese herbal medicine atomizing physiotherapy fumigation stick: Using Chinese herbal medicine raw materials, after drying and pulverizing, a certain amount of binder, smoke generator and water are added. After being extruded by a screw extruder, a semi-finished product is obtained through drying and cutting. Then, through microwave puffing treatment, a fumigation stick finished product with a porous structure is obtained. The extrusion pressure is between 60 bar, the microwave power is 800 w, and the treatment time is 2 minutes.

[0085] The Chinese herbal medicine raw materials are one or a combination of more than one of Alstonia scholaris, Paris vietnamensis, Ardisia crispa, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorum, and are powders with a mesh size of 80 - 100 after drying and crushing treatment. The raw materials have good medicinal effects and a high expansion rate. The binder is one or a combination of more than one of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan. The smoke generator is one or a combination of more than one of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate, or glyceryl caprylate. Specific Embodiment 3

[0087] In this embodiment, the Chinese herbal medicine atomizing physiotherapy fumigation stick produced by the method disclosed in the present invention includes a fumigation stick body 1, an internal cavity 1', and pores 1". The fumigation stick body 1 is cylindrical with an outer diameter of 6.5 mm. The fumigation stick body 1 has an internal cavity 1' inside. The axis of the internal cavity 1' coincides with the axis of the fumigation stick body 1 and is located in the exact middle of the internal cavity. The internal cavity 1' and the fumigation stick body 1 have the same length, both being 45 mm. The axial cross-section of the internal cavity structure 1' is an annular shape with a wall thickness of 2.0 mm.

[0088] The fumigation stick body 1 has pores 1" with a pore size of 1 - 80 μm, arranged uniformly in a honeycomb shape, facilitating heat transfer and the volatilization and release of active ingredients. At the same time, it can carry the liquid medicine 2, which matches the Chinese herbal medicine raw materials of the fumigation stick body 1, further enhancing the medicinal effect.

[0089] Among them, the liquid medicine 2 includes directly added water-soluble medicinal material extracts 21 and microencapsulated powders 22 of oil-soluble liquid medicines after embedding treatment. The microencapsulated powders 22 of oil-soluble liquid medicines are prepared by mixing β-cyclodextrin and the liquid medicine evenly and then through spray drying, forming a semi-closed structure, enabling the liquid medicine to have a sustained-release effect.

[0090] The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick: Using Chinese herbal medicine raw materials, after drying and pulverizing, a certain amount of binder, smoke generator, and water are added. After extrusion by a screw extruder, a semi-finished product is obtained through drying and cutting. Then, after microwave puffing treatment, a fumigation stick finished product with a porous structure is obtained. The extrusion pressure is between 60 bar, the microwave power is 1000 w, and the treatment time is 2 minutes.

[0091] The Chinese herbal medicine raw materials are one or a combination of several of Alstonia yunnanensis, Stephania japonica, Ardisia hanceana, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorus, and are powders with a mesh size of 80 - 100 after drying and crushing treatment. The raw materials have good medicinal effects and a high expansion rate. The binder is one or a combination of several of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan. The smoke generator is one or a combination of several of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate, or glyceryl caprylate. Specific Example 4

[0093] In this embodiment, the Chinese herbal medicine atomizing physiotherapy fumigation stick produced by the method disclosed in the present invention has a fumigation stick body 1 that is cylindrical with an outer diameter of 6.5 mm. The fumigation stick body 1 has an internal cavity 1' inside. The axis of the internal cavity coincides with the axis of the fumigation stick body and is located in the exact middle of the internal cavity. The internal cavity 1' and the fumigation stick body 1 have the same length, both being 45 mm. The axial cross-section of the internal cavity structure 1' is an annular shape with a wall thickness of 3.0 mm.

[0094] The fumigation stick body 1 has a pore structure 1", with a pore size of 1 - 100 μm, arranged uniformly in a honeycomb shape, facilitating heat transfer and the volatilization and release of active ingredients. At the same time, it can carry the liquid medicine 2, which matches the Chinese herbal medicine raw materials of the fumigation stick body 1, further enhancing the medicinal effect.

[0095] The liquid medicine 2 includes the directly added water-soluble herbal extract 21 and the microencapsulated powder 22 of the oil-soluble liquid medicine after embedding treatment. The microencapsulated powder 22 of the oil-soluble liquid medicine is prepared by mixing β-cyclodextrin and the liquid medicine evenly and then through spray drying, forming a semi-closed structure, enabling the liquid medicine to have a sustained release effect.

[0096] Preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick: Using Chinese herbal medicine raw materials, after drying and pulverizing, a certain amount of binder, fuming agent and water are added. After extrusion by a screw extruder, a semi-finished product is obtained through drying and cutting, and then a finished fumigation stick with a porous structure is obtained after microwave puffing treatment. The extrusion pressure is between 60 bar, the microwave power is 1000 w, and the treatment time is 2 minutes.

[0097] The Chinese herbal medicine raw materials are one or a combination of several of Alstonia mairei, Stephania japonica, Ardisia hanceana, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, Platycodon grandiflorum, etc., and are powders with a mesh size of 80 - 100 after drying and crushing treatment. The raw materials have good medicinal effects and a high expansion rate. The binder is one or a combination of several of sodium alginate, methyl cellulose, carboxymethyl cellulose, konjac glucomannan, etc. The fuming agent is one or a combination of several of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, glyceryl triacetate or glyceryl caprylate.

[0098] In the present invention, the hardness, active ingredient content and atomized particle size of the Chinese herbal medicine atomizing physiotherapy fumigation sticks prepared in specific examples 1 - 4 are also measured. The hardness is measured by the point pressure method, the atomized particle size is measured by an aerosol particle size spectrometer, and the active ingredient content of the stick body is measured by a liquid chromatograph. The test results are shown in Table 1:

[0099] Table 1

[0100]

[0101] Put the Chinese herbal medicine atomizing physiotherapy fumigation sticks prepared in Examples 1 - 4 into the heating cavity of the atomizing fumigator, control the heating temperature at 200°C - 500°C, generate atomized particles by heating the fumigation stick with the atomizing fumigator, and test the active ingredient release rate. The active ingredient release rate = the active ingredient content of the atomized particles / the active ingredient content of the stick body × 100%. When inhaling different numbers of breaths, the test results of the active ingredient release rate are shown in Table 2:

[0102] Table 2

[0103] Inhale 1 puff Inhale 3 puffs Inhale 5 puffs Inhale 7 puffs Inhale 9 puffs Inhale 12 puffs Example 1 6％ 26％ 40％ 53％ 76％ 76％ Example 2 9％ 28％ 46％ 62％ 88％ 89％ Example 3 13％ 35％ 56％ 78％ 95％ 96％ Example 4 11％ 33％ 52％ 74％ 92％ 92％

[0104] From the above data, it can be seen that the physical parameters such as the cavity wall thickness and pore size of the Chinese herbal medicine atomizing physiotherapy fumigation stick of the present invention can directly affect the application effect of the fumigation stick product. Comparing Examples 1 to 4, it can be seen that when the cavity wall thickness of the fumigation stick is 0.2 - 3.0 mm and the pore size is 0.1 - 30 μm, the hardness and atomized particle size of the fumigation stick basically meet the product requirements. However, the content of the active ingredient in Example 1 is relatively low, which is related to the relatively small cavity wall thickness of the fumigation stick, the small number of microwave-expanded pore structures and the small pore diameter. Comparing the data of the active ingredient release rate at different numbers of inhalation ports, it can be seen that the active ingredient release rate gradually increases with the increase of the number of inhalation ports, and reaches the peak value when inhaled 9 times, which can achieve the rapid release of the active ingredient. Among them, the treatment effect of Example 3 is the best.

[0105] The working process of the Chinese herbal medicine atomizing physiotherapy fumigation stick prepared by the present invention through this preparation method is as follows:

[0106] The Chinese herbal medicine atomizing physiotherapy fumigation stick disclosed in the present invention is adapted to the existing atomizing fumigation appliances on the market, and its heating temperature is controlled at 300 °C. The atomizing fumigation appliance 3 includes a feeding end 4 and a suction end 5. The feeding end 4 and the interior of the atomizing fumigation appliance 3 form a cylindrical heating chamber 6, which is used to place the Chinese herbal medicine atomizing physiotherapy fumigation stick. The diameter of the heating chamber 6 is 7.5 mm and the length is 60 mm. When in use, the Chinese herbal medicine atomizing physiotherapy fumigation stick is placed in the heating chamber 6 of the atomizing fumigation appliance 3, and atomized particles with a particle size less than 2.5 μm are generated by heating the fumigation stick through the atomizing fumigation appliance 3. Consumers can accurately deliver the drug components to the upper respiratory tract and lungs by biting the filter device, realizing stable release and high-efficiency treatment, and having the potential for treating multiple diseases.

[0107] Usage Scenario 1: When the Chinese herbal medicine atomizing physiotherapy fumigation stick is used in combination with the atomizing fumigation appliance 3, the stick body 1 of the fumigation stick is inserted from the bottom feeding end of the atomizing fumigation appliance 3, and the remaining length is 20 mm, which is convenient for disassembly and assembly. After the heating chamber 6 inside the atomizing fumigation appliance 3 heats the stick body 1 of the fumigation stick, atomized particles are generated.

[0108] Usage Scenario 2: The stick body 1 of the fumigation stick is inserted from the top feeding end 4 of the atomizing fumigation appliance 3. The filter device 7 sleeved above the heating chamber 6 includes a mouthpiece section 71 and a base 72. The mouthpiece section 71 and the base 72 are connected as a whole and have an internal hollow structure. The inner bottom edge of the base 72 has a card slot, which can be exactly and hermetically sleeved with the atomizing fumigation appliance 3. The material of the filter device 7 is low-density polyethylene resin (LDPE). The outer diameter of the top of the mouthpiece section 71 is 6 mm, the outer diameter of the bottom is 7.0 mm, and the length is 15 mm. The hollow structure is filled with a filter cotton stick, and the length of the cotton stick is 10 mm. The height of the base 72 is 25 mm.

[0109] Usage Scenario 3: The fumigation stick body 1 is inserted from the top feeding end 4 of the atomizing fumigator. The filter device 7 above the heating chamber 6 is a paper tube filter directly sleeved with the remaining part of the fumigation stick body 1. One end inside the paper tube is filled with a filtering section 8, and the filtering section 8 is a cotton swab with a length of 10 mm. The other end is a cavity 9 with an inner diameter of 6.7 mm and a length of 15 mm, which can be directly sleeved with the fumigation stick.

[0110] In the figure, the description of the positional relationship is only for illustrative purposes and should not be construed as a limitation of this patent. Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the implementation manners of the present invention. For those of ordinary skill in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to enumerate all the implementation manners here. Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention shall be included in the protection scope of the claims of the present invention.

Claims

1. A preparation method of a Chinese herbal medicine atomizing physiotherapy fumigation stick, characterized in that, It includes the following steps: S1. Dry the Chinese herbal medicine raw materials and then perform pulverization treatment to obtain Chinese herbal medicine raw material powder; S2. Add a binder, a fumigant, and water to the Chinese herbal medicine raw material powder, and stir evenly to obtain an intermediate state mixture; S3. Input the intermediate state mixture in step S2 into a screw extruder, and use an integral molding process to extrude a fumigation rod prototype with an internal cavity, and successively perform drying treatment and cutting treatment on the extruded fumigation rod prototype to obtain a semi-finished fumigation rod; S4. Perform microwave puffing treatment on the semi-finished fumigation rod to obtain a fumigation rod with pores; S5. Spray water-soluble Chinese herbal medicine extract particles and oil-soluble liquid medicine microencapsulated powder on the fumigation rod to form a semi-closed structure. When the water-soluble Chinese herbal medicine extract particles and the oil-soluble liquid medicine microencapsulated powder burn along with the fumigation rod, the fumigation rod has a liquid medicine slow-release effect.

2. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, wherein, The following steps are further included in step S1: S11. Select one or more combinations of Chinese herbal medicine raw materials and perform drying treatment on them; S12. Use a crusher to crush the dried Chinese herbal medicine raw materials to obtain Chinese herbal medicine raw material powder with a mesh size of 80 - 100; 3. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The following steps are further included in step S2: S21. Mix one or more combinations of Chinese herbal medicine raw material powder evenly and pour it into a mixer; S22. Pour the binder, the fumigant, and water into the mixer, and stir evenly with the Chinese herbal medicine raw material powder to obtain an intermediate state mixture.

4. The preparation method of the Chinese herbal medicine atomization physiotherapy fumigation stick according to claim 1, characterized in that, The following steps are further included in step S3: S31. Set a cavity former for forming an internal cavity at the output end of the screw extruder, and input the intermediate state mixture in step S2 into the screw extruder; S32. Use an integral molding process, and the screw extruder extrudes the intermediate state mixture to obtain a fumigation rod prototype with an internal cavity; S32. Input the fumigation rod prototype into a dryer for drying treatment; S33. Transport the dried fumigation rod prototype to a cutting mechanism for cutting to obtain a semi-finished fumigation rod.

5. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The following steps are further included in step S4: S41. Control the microwave power of the microwave puffing machine at 300w - 1000w, and put the semi-finished fumigation rod into it; S42. Use the microwave puffing machine to heat the semi-finished fumigation rod for 1 - 10 minutes, so that after the semi-finished fumigation rod is microwave-puffed, a fumigation rod with pores on the surface is obtained.

6. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The following steps are further included in step S5: S51. Dissolve the water-soluble medicine in water to obtain an aqueous solution of water-soluble Chinese herbal medicine, and dissolve the β-cyclodextrin oil-soluble medicine in oil to obtain a mixed solution of β-cyclodextrin and oil; S52. Transport the aqueous solution of water-soluble Chinese herbal medicine to a spray dryer and use spray drying to obtain water-soluble Chinese herbal medicine extract particles, and transport the mixed solution of β-cyclodextrin and oil to a spray dryer and use spray drying to obtain oil-soluble liquid medicine microencapsulated powder; S53. Spray the water-soluble Chinese herbal medicine extract particles and the oil-soluble liquid medicine microencapsulated powder onto the fumigation rod in sequence to form a semi-closed structure, so that when the fumigation rod is ignited, the water-soluble Chinese herbal medicine extract particles and the oil-soluble liquid medicine microencapsulated powder have a slow-release effect during combustion.

7. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 4, characterized in that, The extrusion pressure of the screw extruder is controlled at 20 bar to 80 bar. The cross-section of the fumigation rod prototype is one of an annular shape, a pentagram shape, and a cross shape, and the wall thickness of the fumigation rod prototype is 0.2 to 3 mm.

8. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The Chinese medicinal material raw material is one or a combination of several of Alstonia scholaris, Aristolochia kaempferi, Geophila herbacea, Momordica grosvenori, Lonicera japonica, Ophiopogon japonicus, and Platycodon grandiflorum.

9. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The binder is one or a combination of several of sodium alginate, methyl cellulose, carboxymethyl cellulose, and konjac glucomannan.

10. The preparation method of the Chinese herbal medicine atomizing physiotherapy fumigation stick according to claim 1, characterized in that, The fuming agent is one or a combination of several of propylene glycol, glycerol, polyethylene glycol, triethyl citrate, triacetin, or glyceryl caprylate.

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