Preparation process of herbaceous plant with effects of consolidating basis and consolidating primordial qi

Abstract

The invention relates to the technical field of the efficacy of consolidating basis, in particular to a preparation process of a herbaceous plant with the efficacy of consolidating basis, which comprises 900 g of actinolite, 200 g of radix angelicae pubescentis, 200 g of radix paeoniae rubra, 300 g of fructus rosae laevigatae, 200 g of salvia miltiorrhiza, 150 g of pseudo-ginseng, 200 g of American ginseng, 300 g of herba epimedii, 200 g of morinda officinalis, 200 g of eucommia ulmoides and 200 g of radix rehmanniae preparata. Kidney-warming and yang-tonifying medicinal materials such as actinolite, herba epimedii and radix morindae officinalis can be scientifically matched and have a synergistic effect with qi-tonifying and superficies-strengthening medicines such as radix astragali, rhizoma atractylodis macrocephalae and American ginseng, and the radix rehmanniae preparata and the fructus schizandrae are combined for nourishing yin and tonifying kidney, so that medicine property balance of warming yang without dryness and nourishing yin without greasiness is formed; the traditional Chinese medicine composition is suitable for comprehensive conditioning of kidney-yang insufficiency, qi deficiency, body weakness and other symptoms, and the kidney-spleen-qi-blood multi-system consolidating basis is realized. The traditional Chinese medicine composition is suitable for comprehensive conditioning of kidney-yang insufficiency, qi deficiency, body weakness and the like.

Description

Technical Field

[0001] The present invention relates to the technical field of the efficacy of strengthening the primordial qi and cultivating the root, and specifically relates to a preparation process of herbal plants with the efficacy of strengthening the primordial qi and cultivating the root. Background Art

[0002] Strengthening the primordial qi and cultivating the root is one of the core theories in traditional Chinese medicine for preventing and treating deficiency syndromes, aiming to restore the fundamental functions of the body by regulating the zang-fu organs and supplementing qi, blood, yin and yang. At present, the herbal products with the efficacy of "strengthening the primordial qi and cultivating the root" on the market mainly include traditional Chinese medicine mixtures, medicinal wines, medicinal plasters, etc., and their preparation processes are mostly based on traditional soaking and decocting techniques. Generally, the following technical bottlenecks exist: the traditional single soaking process has insufficient consideration for both polar and non-polar components. For example, it is difficult to synchronously and fully release the mineral ions in actinolite and the flavonoid compounds in epimedium, resulting in a weak material basis for the medicinal effect and insufficient control of toxic components. For the preparations containing toxic herbs such as aconite and asarum, if the processing technology is not standardized, it is easy to cause the residue of toxic components such as aconitine to exceed the standard, and there are potential safety hazards in clinical applications. In the existing technology, there is a lack of quantitative standards for raw material treatment and key process parameters, resulting in significant fluctuations in the quality of products in different batches, and it is difficult to pass the modern preparation quality evaluation system. For the traditional processing of aconite, single water immersion or direct boiling is mostly used, lacking quantitative research on the synergistic detoxification of auxiliary materials such as licorice and black beans, and the removal rate of aconitine is unstable. In the calcination and quenching process of actinolite, the proportion of vinegar quenching and the grinding particle size are not standardized, resulting in a difference in the dissolution rate of magnesium oxide of more than 30%. The conventional soaking method does not consider the differential effect of temperature on the component dissolution. For example, the dissolution rate of fat-soluble components is less than 50% in a low-temperature environment, and heat-sensitive components are easily degraded in a high-temperature environment. During the decocting process, the filtration accuracy is insufficient, resulting in a high turbidity of the finished product, and the residual rate of active ingredients in the medicinal residues reaches 15%-20%. Most processes do not introduce modern pharmaceutical technologies such as vacuum concentration and aseptic filling, resulting in a high loss rate of heat-sensitive components and a significant risk of microbial contamination. Therefore, we propose a preparation process of herbal plants with the efficacy of strengthening the primordial qi and cultivating the root to solve the above-mentioned problems. Summary of the Invention

[0003] The purpose of the present invention is to provide a preparation process of herbal plants with the efficacy of strengthening the primordial qi and cultivating the root to solve the problems mentioned in the above background art.

[0004] The technical solution of the present invention is: A preparation process of a herbal plant with the efficacy of strengthening the body resistance and nourishing the primordial qi, including 900 grams of actinolite, 200 grams of angelica pubescens, 200 grams of red peony root, 300 grams of rose laurel fruit, 200 grams of salvia miltiorrhiza, 150 grams of pseudo-ginseng, 200 grams of american ginseng, 300 grams of epimedium, 200 grams of morinda officinalis, 200 grams of eucommia ulmoides, 200 grams of rehmannia glutinosa, 300 grams of schisandra chinensis, 200 grams of atractylodes macrocephala, 300 grams of astragalus membranaceus, 200 grams of gardenia jasminoides, 200 grams of coptis chinensis, 200 grams of picrorhiza kurrooa, 300 grams of cynomorium songaricum, 400 grams of cistanche deserticola, 200 grams of akebia quinata, 200 grams of dahurian angelica root, 150 grams of dried ginger, 200 grams of prepared aconite root, 100 grams of asarum sieboldii, 200 grams of clerodendrum bungei, 200 grams of cistanche salsa, 150 grams of acorus tatarinowii, 1000 grams of honey, 4000 grams of white liquor; including the following steps: S1: Remove impurities from the raw materials except actinolite, honey and white liquor, wash them, dry them to a water content ≤ 12%, and cut them into 3 - 5 mm slices. Among them, eucommia ulmoides and morinda officinalis need to be crushed to a particle size ≤ 2 mm; S2: Calcinate actinolite with strong fire for 2 hours until it is completely red, pour it into rice vinegar according to the weight ratio of stone to vinegar of 1:0.5 for quenching and crisping, dry it and grind it to a passing rate of ≥ 95% through an 80 - mesh sieve; S3: Soak the purified aconite root for 10 - 15 days, boil it with licorice and black beans according to the weight ratio of 1:0.3:0.6 for 3 hours, cut it into 2 mm thin slices and dry it to a water content ≤ 8%; S4: Mix the slices with actinolite powder, add 52° white liquor according to the material - liquid ratio of 1:5, soak it at 25℃ for 10 days first, and then raise the temperature to 30℃ for continuous soaking for 10 days; S5: Decoct the soaking solution and the materials with slow fire for 2.5 hours, filter it, add the same amount of white liquor to the medicinal residues for re - decocting for 1.5 hours, and combine the filtrates; S6: Concentrate the filtrate under the conditions of - 0.07 MPa vacuum degree and 65℃ to a relative density of 1.18; S7: Heat the honey to 115℃ to refine it into medium honey, cool it to 45℃, add the clear paste according to the weight ratio of honey to paste of 1:1.2, and stir it at 100 r / min for 15 minutes; S8: Age the mixture in a cool place for 15 days, filter it through diatomaceous earth and then fill it aseptically.

[0005] Preferably, during the first soaking in S4, it needs to be stirred once a day, and during the continuous soaking period, it needs to be stirred once every other day.

[0006] Preferably, the first decoction liquid in S5 needs to be filtered through a 120 - mesh sieve while it is hot, and the re - decoction liquid needs to be filtered through a 200 - mesh sieve after cooling to room temperature.

[0007] Preferably, during the process of S6, the evaporation rate needs to be controlled to reduce the volume of the filtrate by 15% - 20% per hour.

[0008] Preferably, the relative density is measured at a blending temperature of 25°C, and the relative density of the honey to be detected at S7 is 1.37 - 1.40.

[0009] Preferably, the addition amount of diatomaceous earth in the step S8 is 0.3% - 0.5% of the weight of the mixture.

[0010] Preferably, the aseptic filling process needs to be carried out in an environment with a cleanliness of ≥10,000 levels, and the filling temperature is controlled at 30 - 40°C.

[0011] The present invention provides an improved preparation process of herbal plants with the efficacy of strengthening the root and cultivating the primordial qi. Compared with the prior art, it has the following improvements and advantages: First: In the present invention, by first soaking at a low temperature to promote the dissolution of polar components, and then raising the temperature to accelerate the release of fat-soluble components, combined with segmented decoction of "slow fire - strong fire", components such as minerals in actinolite, aconitine in aconite, and active enzymes in honey are fully dissolved. Compared with the traditional single soaking process, the extraction rate of active ingredients is increased by about 25%. The low-temperature and reduced-pressure environment avoids the degradation of thermosensitive components. At the same time, viscous protective films are formed by refining honey to enhance the stability of active ingredients. The content of ginsenoside Rg1 in the finished product is 18% higher than that of the conventional process.

[0012] Second: In the present invention, by scientifically combining warm kidney and strengthening yang medicinal materials such as actinolite, epimedium, and morinda officinalis, synergistically acting with qi-tonifying and surface-strengthening drugs such as astragalus membranaceus, atractylodes macrocephala, and american ginseng, and combining the nourishing yin and tonifying the kidney of rehmannia glutinosa and schisandra chinensis, a balance of medicinal properties of "warming yang without dryness and nourishing yin without greasiness" is formed. At the same time, blood-activating and collaterals-unblocking components such as notoginseng, salvia miltiorrhiza, and clerodendrum bungei can improve blood circulation and assist yang qi to reach the whole body, realizing the overall strengthening of the root and cultivation of the primordial qi of multiple systems of "kidney - spleen - qi and blood", and is suitable for the comprehensive conditioning of symptoms such as insufficient kidney yang and weak qi.

[0013] Third: In the present invention, through double processing of prepared aconite by "soaking and rinsing - co-boiling with licorice and black beans", the aconitine content is reduced to less than 0.02 mg / g. Combined with calcining and quenching actinolite to remove impurities, the toxicity risk is reduced from the source. Quantitative standards are set for process nodes such as raw material factory inspection, intermediate product filtration accuracy, and aging environment to ensure that the component content fluctuation between finished product batches is ≤5%. And diatomaceous earth filtration is used to remove tiny impurities, and the clarity reaches the standard of mixture. Brief Description of the Drawings

[0014] The present invention will be further explained below with reference to the drawings and embodiments: Figure 1 is the process flow chart of the preparation process of the present invention; Figure 2 is the comparison chart of the dissolution rate of active ingredients of the present invention; Figure 3 is the heat map of storage condition stability of the present invention; Detailed Embodiments

[0015] The present invention will be described in detail below. The technical solutions in the embodiments of the present invention will be clearly and completely described. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts belong to the scope of protection of the present invention.

[0016] The present invention provides an improved preparation process of a herbal plant with the efficacy of strengthening the root and cultivating the primordial qi. The technical solution of the present invention is as follows: As Figure 1 - Figure 3 shown, a preparation process of a herbal plant with the efficacy of strengthening the root and cultivating the primordial qi includes 900 grams of actinolite, 200 grams of angelica pubescens, 200 grams of red peony root, 300 grams of fructus rosae laevigatae, 200 grams of salvia miltiorrhiza, 150 grams of notoginseng, 200 grams of american ginseng, 300 grams of epimedium, 200 grams of morinda officinalis, 200 grams of eucommia ulmoides, 200 grams of rehmannia glutinosa, 300 grams of schisandra chinensis, 200 grams of atractylodes macrocephala, 300 grams of astragalus membranaceus, 200 grams of gardenia jasminoides, 200 grams of coptis chinensis, 200 grams of ground gall, 300 grams of cynomorium songaricum, 400 grams of cistanche deserticola, 200 grams of akebia quinata, 200 grams of angelica dahurica, 150 grams of dried ginger, 200 grams of prepared aconite root, 100 grams of asarum sieboldii, 200 grams of clerodendrum bungei, 200 grams of cistanche salsa, 150 grams of acorus tatarinowii, 1000 grams of honey, and 4000 grams of white wine; it includes the following steps: S1: Remove impurities from the raw materials except actinolite, honey, and white wine, wash them, dry them to a water content of ≤ 12%, and cut them into 3 - 5 mm slices. Among them, eucommia ulmoides and morinda officinalis need to be crushed to a particle size of ≤ 2 mm; S2: Calcinate actinolite with strong fire for 2 hours until it is completely red, pour it into rice vinegar according to the weight ratio of stone to vinegar of 1:0.5, quench it until it becomes brittle, dry it, and grind it until the passing rate through an 80 - mesh sieve is ≥ 95%; S3: Soak the clean aconite root for 10 - 15 days, boil it with licorice and black beans according to the weight ratio of 1:0.3:0.6 for 3 hours, cut it into 2 mm thin slices, and dry it to a water content of ≤ 8%; S4: Mix the slices with actinolite powder, add 52° white wine according to the material - liquid ratio of 1: five, soak it at 25°C for 10 days first, and then raise the temperature to 30°C and continue to soak for 10 days; S5: Decoct the soaking solution and the materials with slow fire for 2.5 hours, filter, add the same amount of white wine to the medicinal residues and decoct for 1.5 hours, and combine the filtrates; S6: Concentrate the filtrate under the conditions of a vacuum degree of - 0.07 MPa and 65°C to a relative density of 1.18 (measured at 60°C); S7: Heat the honey to 115°C and refine it into medium honey. When the temperature drops to 45°C, add the clear paste according to the weight ratio of honey to paste of 1:1.2, and stir it at 100 r / min for 15 minutes; S8: The mixture is aged for 15 days in a cool place, filtered through diatomaceous earth, and then aseptically filled.

[0017] Furthermore, during the first soaking in S4, it is necessary to stir once a day, and during the subsequent soaking, stir once every other day. By differentiating the stirring frequency, the dissolution efficiency of the components is improved.

[0018] Furthermore, the first decoction liquid in S5 needs to be filtered through a 120-mesh sieve while it is still hot, and the re-decocted liquid is filtered through a 200-mesh sieve after cooling to room temperature. Using high temperature to reduce the viscosity of the filtrate can quickly intercept larger particulate impurities, and at the same time avoid the precipitation of resinous components due to temperature drop, which may block the sieve. The filtration efficiency is increased by 30%.

[0019] Furthermore, during the process of S6, it is necessary to control the evaporation rate to reduce the volume of the filtrate by 15%-20% per hour. Uniform evaporation can avoid the degradation of active ingredients caused by local overheating.

[0020] Furthermore, the relative density is measured at a blending temperature of 25°C. During S7, it is necessary to detect that the relative density of the honey is 1.37 - 1.40. The reducing sugar in the qualified honey can form Maillard reaction precursors with the amino acids in the drug, slowly release trace active substances, and enhance the persistence of the tonic effect of the finished product.

[0021] Furthermore, the addition amount of diatomaceous earth in step S8 is 0.3%-0.5% of the weight of the mixture. As a filter aid, the porous structure of diatomaceous earth can adsorb colloidal particles and metal ions with a size of ≤10μm in the filtrate. When the addition amount is optimized to 0.3%-0.5%, it can not only form a uniform filter cake layer to improve the filtration speed, but also avoid the loss of active ingredients caused by excessive use.

[0022] Furthermore, the aseptic filling process needs to be carried out in an environment with a cleanliness level of ≥10,000. The filling temperature is controlled at 30 - 40°C. The filling temperature of 30 - 40°C is close to the human body temperature, which can reduce the adhesion of the highly viscous extract to the container wall, and at the same time avoid the solidification of honey components at low temperature, which may block the filling head, thus improving the production efficiency.

[0023] The above description enables those skilled in the art to implement or use the present invention. Various modifications to these embodiments will be obvious to those skilled in the art. The general principles defined herein can be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to these embodiments shown herein, but rather will be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A preparation process of a herbaceous plant with the efficacy of strengthening the root and cultivating the primordial qi, including 900 grams of actinolite, 200 grams of angelica pubescens, 200 grams of red peony root, 300 grams of rose laurel fruit, 200 grams of salvia miltiorrhiza, 150 grams of notoginseng, 200 grams of American ginseng, 300 grams of epimedium, 200 grams of morinda officinalis, 200 grams of eucommia ulmoides, 200 grams of rehmannia glutinosa, 300 grams of schisandra chinensis, 200 grams of atractylodes macrocephala, 300 grams of astragalus membranaceus, 200 grams of gardenia jasminoides, 200 grams of coptis chinensis, 200 grams of ground gall, 300 grams of cynomorium songaricum, 400 grams of desertliving cistanche, 200 grams of akebia quinata, 200 grams of angelica dahurica, 150 grams of dried ginger, 200 grams of prepared aconite root, 100 grams of asarum, 200 grams of clerodendrum bungei, 200 grams of cistanche salsa, 150 grams of acorus tatarinowii, 1000 grams of honey, and 4000 grams of white liquor; it is characterized in that: It includes the following steps: S1: Remove impurities from the raw materials except actinolite, honey, and white liquor. After washing, dry them to a water content of ≤12%, and cut them into 3-5 mm slices. Eucommia ulmoides and morinda officinalis need to be crushed to a particle size of ≤2 mm; S2: Calcinate actinolite with strong fire for 2 hours until it is completely red, pour it into rice vinegar at a weight ratio of stone to vinegar of 1:0.5 for quenching and crisping, dry it and grind it until the passing rate through an 80-mesh sieve is ≥95%; S3: Soak the cleaned aconite for 10-15 days (changing water twice a day), boil it with licorice and black beans at a weight ratio of 1:0.3:0.6 for 3 hours, cut it into 2 mm thin slices and dry it to a water content of ≤8%; S4: Mix the slices with actinolite powder, add 52° white liquor at a material-liquid ratio of 1:5, soak it at 25°C for 10 days first, and then raise the temperature to 30°C for continuous soaking for 10 days; S5: Decoct the soaking solution and the materials with gentle fire (temperature ≤90°C) for 2.5 hours, filter, and decoct the residue with an equal amount of white liquor for 1.5 hours, and combine the filtrates; S6: Concentrate the filtrate under a vacuum of -0.07 MPa and at 65°C to a relative density of 1.18 (measured at 60°C); S7: Heat the honey to 115°C to refine it into medium honey, cool it to 45°C, and add the clear paste at a weight ratio of honey paste to 1:1.2, and stir it at 100 r / min for 15 minutes; S8: Age the mixture in a cool place (temperature ≤20°C, humidity ≤50%) for 15 days, filter it through diatomite and then fill it aseptically; 2. The preparation process of a herbaceous plant with the efficacy of strengthening the root and cultivating the primordial qi according to claim 1, characterized in that: During the first soaking in S4, it needs to be stirred once a day, and during the continuous soaking period, it needs to be stirred once every other day.

3. The preparation process of a herbaceous plant with the efficacy of strengthening the primordial qi and cultivating the root, as described in claim 1, is characterized in that: The first decoction liquid in S5 needs to be filtered through a 120-mesh sieve while it is hot, and the re-decocted liquid needs to be filtered through a 200-mesh sieve after cooling to room temperature.

4. The preparation process of a herbaceous plant with the efficacy of strengthening the root and cultivating the primordial qi according to claim 1, characterized in that: During the process of S6, it is necessary to control the evaporation rate to reduce the volume of the filtrate by 15%-20% per hour.

5. The preparation process of a herbal plant with the efficacy of strengthening the primordial qi according to claim 1, characterized in that: The relative density is measured at a blending temperature of 25°C, and during S7, the relative density of the honey needs to be detected as 1.37-1.

40.

6. The preparation process of a herbaceous plant with the efficacy of strengthening the primordial qi according to claim 1, characterized in that: The addition amount of diatomite in step S8 is 0.3%-0.5% of the weight of the mixture.

7. The preparation process of a herbaceous plant with the efficacy of strengthening the primordial qi and cultivating the root, as described in claim 1, is characterized in that: The aseptic filling process needs to be carried out in an environment with a cleanliness level of ≥10,000, and the filling temperature is controlled at 30-40°C.

Images