Spreader for clinical treponema pallidum non-specific antibody detection test

Abstract

The invention discloses a coater for clinical treponema pallidum non-specific antibody detection test. The coater comprises a main body hollow handle, a rubber coating sleeve and a standby liquid injector, wherein the main body hollow handle comprises a handle body, a handle piston rod, a liquid injection port and a main body needle head; the rubber smearing sleeve is integrally formed and comprises an outer wrapping connector and a smearing wafer. And the liquid injection part comprises an independent standby injector. The coater can store liquid, is large and uniform in coating surface and convenient to operate, the liquid outlet amount is convenient to adjust due to piston type liquid outlet, the needle head, the coating wafer and the like can be replaced, the problem of coating a serum specimen is effectively solved, and the coater is used for coating a treponema pallidum non-specific antibody detection test specimen.

Description

Technical Field

[0001] The present invention belongs to the technical field of analytical methods and devices in the fields of analytical chemistry, biochemistry, medical diagnosis, etc., and particularly relates to an applicator for detecting non-specific antibodies of Treponema pallidum in clinical practice. Background Art

[0002] In clinical practice, when detecting non-specific antibodies of Treponema pallidum by the TRUST method, the step of "uniformly coating the specimen within the entire reaction circle" in the detection operation procedure is very crucial. Whether 50 μL of the serum / plasma specimen to be detected is uniformly coated within the entire reaction circle is very important, which directly affects the detection result. Failure to coat the entire reaction circle may result in false-negative results. The level of non-specific antibodies of syphilis is positively correlated with the strength of the immune reaction agglutination, reflecting the specific disease course status of the patient and the formulation of the treatment plan.

[0003] During clinical work and teaching, doctors found that interns, resident doctors, new employees with insufficient experience, and senior employees could not achieve ideal results in this simple specimen coating work. After investigation, it was found that the equipment currently used for coating specimens is not suitable enough. Currently, in clinical practice, a 200 μL pipette tip is used to coat the specimen. The contact area between the pipette tip and the serum / plasma is small, and it takes about 30 strokes to evenly coat the specimen throughout the circle, and air bubbles are likely to appear. However, there are so many clinical specimens every day, and not everyone will be so careful in doing this coating operation. Over time, the coated area does not meet the standard, and the pipette tip often scratches the reaction plate. The technical problem to be solved by the present invention is the non-compliance problem caused by excessive coating quantity and workload of serum specimens during the detection test of non-specific antibodies of Treponema pallidum. Summary of the Invention

[0004] The purpose of the present invention is to provide an applicator for detecting non-specific antibodies of Treponema pallidum in clinical practice. The contact surface of the applicator with the serum specimen is the center of the circle and has a large contact area, which is convenient for coating the specimen, achieving the required coating area for the test, and is not likely to appear holes and bubbles, affecting the subsequent mixing of serum and reagent and the interpretation of the result. It solves the problem of coating serum specimens during the detection test of non-specific antibodies of Treponema pallidum in the prior art.

[0005] To achieve the above purpose, the present invention adopts the following technical solutions to be implemented: An applicator for the clinical detection test of Treponema pallidum non-specific antibody, characterized in that it comprises: a main body hollow handle, a rubber coating sleeve and a spare syringe; wherein, the main body hollow handle 1 comprises a handle body, a handle piston rod, a liquid injection port and a main body needle; the rubber coating sleeve is integrally formed and comprises an outer wrapping joint and a coating disc; the liquid injection part comprises an independent spare syringe.

[0006] Preferably, the handle body is in a cylindrical shape, with one end open for the handle piston rod to retract and extend when it moves, and the other end is provided with a needle mounting part, and the main body needle is mounted on the needle mounting part.

[0007] Preferably, an axial long groove is formed on the side surface of the handle body 11 close to the open end of the cylinder, and a liquid injection port with a protruding edge is arranged at one end of the handle body close to the main body needle. The liquid injection port communicates with the outside, and threads are arranged both inside and outside the protruding edge.

[0008] Preferably, the long groove and the liquid injection port are arranged diagonally in the radial direction, and the long groove and the liquid injection port are respectively located on both sides of the handle body.

[0009] Preferably, the handle piston rod is installed inside the handle body. The handle piston rod comprises a piston, a piston rod and a plug. The piston and the plug are connected to both ends of the piston rod. A convex button is fixedly arranged on the piston rod, and the convex button can slide axially in the long groove.

[0010] Preferably, the liquid injection port comprises a concave cover with holes, a rubber top plug and an outer cover. The concave cover is threadedly installed inside the protruding edge of the liquid injection port. The rubber top plug is installed inside the concave cover, and the outer cover is screwed onto the thread on the protruding edge.

[0011] Preferably, there is a hole on the outer wrapping joint at one end of the rubber coating sleeve, which is sleeved on the outer cover of the liquid injection port on the protruding edge of the handle body to prevent the rubber coating sleeve from falling off the handle body. Preferably, the rubber top plug is for preventing liquid leakage, and the outer cover is for preventing the rubber top plug from being extruded and falling off.

[0012] Preferably, the concave cover is provided with an injection hole. The outer edge of the concave cover is stuck outside the protruding edge, and there is a certain distance between the concave cover body and the inner arc surface of the cylinder of the handle body 11 to prevent interference when the piston slides down or up.

[0013] Preferably, there is a hole in the outer connection joint at one end of the rubber coating sleeve, which is sleeved on the outer cover of the liquid injection port on the protruding edge of the handle body. The coating disc is fixedly arranged at the other end of the outer connection joint. The axis of the outer connection joint and the plane where the coating disc is located are inclined at 45°. The coating surface of the coating disc is a horizontal plane, and the center of the coating disc is provided with a liquid outlet hole.

[0014] Preferably, the handle body drives the piston to suck the liquid into the main body needle by sliding the convex button upward; the spare syringe injects the liquid to be applied into the handle body by unscrewing the outer cover, pulling out the rubber top plug, and inserting it into the injection hole on the concave cover.

[0015] Preferably, the plug of the handle piston rod has a dust-proof function. Sliding the convex button downward drives the piston to inject liquid into the rubber coating sleeve, and the coating liquid flows out from the liquid outlet hole at the center of the coating disc.

[0016] Compared with the prior art, the beneficial effects of the present invention are as follows: The main hollow handle of the applicator in this application can store liquid for multiple applications. The needle, coating disc, and rubber top plug of the applicator are disposable and replaceable. The coating surface of this application is relatively large and the coating is uniform. The main hollow handle is at a 45° angle for easy operation. This application adopts a piston injection type for liquid output, which is convenient for adjusting the liquid output volume. The spare syringe in this application serves as a spare liquid replenishing device. The handle piston rod of the main hollow handle of this application uses a side-pushing convex button, which is convenient for single-handed grasping and controlling the liquid output. Description of the Drawings

[0017] The drawings forming a part of the present invention are used to provide a further understanding of the present invention. The schematic embodiments and descriptions thereof of the present invention are used to explain the present invention and do not constitute an improper limitation to the present invention. In the drawings: Figure 1 It is a schematic diagram of the main structure in the applicator for the clinical detection test of treponema pallidum non-specific antibody in the present invention; Figure 2 It is a schematic diagram of the structure of the liquid injection port part in the applicator for the clinical detection test of treponema pallidum non-specific antibody in the present invention.

[0018] Main hollow handle 1, handle body 11, handle piston rod 12, piston 121, piston rod 122, plug 123, convex button 124, liquid injection port 13, concave cover 131, rubber top plug 132, outer cover 133, main body needle 14, needle mounting part 15, long groove 16; Rubber coating sleeve 2, outer connection joint 21, coating disc 22; Spare injector 3, spare syringe 31. Detailed Embodiments

[0019] Unless otherwise defined, the technical terms used in the following embodiments have the same meanings as commonly understood by those skilled in the art to which the present invention pertains. The test reagents used in the following embodiments are all conventional biochemical reagents unless otherwise specified; the experimental methods are all conventional methods unless otherwise specified.

[0020] The technical solutions of the present invention will be further described below through specific embodiments. Those skilled in the art should understand that the embodiments are only for helping to understand the present invention and should not be regarded as specific limitations on the invention.

[0021] As Figure 1 and Figure 2 shown, this embodiment provides an applicator for the clinical detection test of non-specific antibodies of Treponema pallidum, which is characterized by including: a main body hollow handle 1, a rubber coating sleeve 2, and a spare injector 3; wherein, the main body hollow handle 1 includes a handle body 11, a handle piston rod 12, a liquid injection port 13, and a main body needle 14; the rubber coating sleeve 2 is integrally formed and includes an outer connection joint 21 and a coating disc 22; the liquid injection part 3 includes an independent spare syringe 31.

[0022] The handle body 11 is in a cylindrical shape, with one end open for the handle piston rod 12 to retract and extend when it moves, and the other end is provided with a needle mounting part 15, and the main body needle 14 is mounted on the needle mounting part 15.

[0023] The side surface of the handle body 11 close to the open end of the cylinder is provided with an axial long groove 16, and the end of the handle body 11 close to the main body needle 14 is provided with a liquid injection port 13 with a protruding edge. The liquid injection port 13 communicates with the outside, and threads are provided both inside and outside the protruding edge.

[0024] The long groove 16 and the liquid injection port 13 are arranged radially diagonally, and the long groove 16 and the liquid injection port 13 are respectively located on both sides of the handle body 11.

[0025] The handle piston rod 12 is installed inside the handle body 11. The handle piston rod 12 includes a piston 121, a piston rod 122, and a plug 123. The piston 121 and the plug 123 are connected to both ends of the piston rod 122. A convex button 124 is fixedly provided on the piston rod 122, and the convex button 124 can axially slide in the long groove 16.

[0026] The liquid injection port 13 includes a concave cover 131 with holes, a rubber top plug 132, and an outer cover 133. The concave cover 131 is threadedly installed inside the protruding edge of the liquid injection port 13. The rubber top plug 132 is installed inside the concave cover 131, and the outer cover 133 is screwed on the thread on the protruding edge.

[0027] One end of the rubber coating sleeve 2 has a hole in the outer connection joint 21 thereof, which is sleeved on the outer cover 133 of the liquid injection port 13 at the protruding edge of the handle body 11 to prevent the rubber coating sleeve 2 from falling off the handle body 11. The rubber plug 132 is for preventing liquid leakage, and the outer cover 133 is for preventing the rubber plug 132 from being extruded and falling off.

[0028] The concave cover 131 is provided with an injection hole. The outer edge of the concave cover 131 is stuck outside the protruding edge, and the body of the concave cover 131 is at a certain distance from the inner arc surface of the cylinder of the handle body 11 to prevent interference when the piston 121 slides down or up.

[0029] One end of the rubber coating sleeve 2 has a hole in the outer connection joint 21 thereof, which is sleeved on the outer cover 133 of the liquid injection port 13 at the protruding edge of the handle body 11. The coating disc 22 is fixedly arranged at the other end of the outer connection joint 21. The axis of the outer connection joint 21 and the plane where the coating disc 22 is located are inclined at 45°. The coating surface of the coating disc 22 is a horizontal plane, and the center of the coating disc 22 is provided with a liquid outlet hole.

[0030] The handle body 11 drives the piston 121 to suck liquid into the main body needle 14 by sliding the convex button 124 upward; the spare syringe 31 injects the liquid to be applied into the handle body 11 by unscrewing the outer cover 133, pulling out the rubber plug 132, and extending into the injection hole on the concave cover 131.

[0031] The plug 123 of the handle piston rod 12 has a dust-proof function. Sliding the convex button 124 downward drives the piston 121 to inject liquid into the rubber coating sleeve 2, and the coating liquid flows out from the liquid outlet hole at the center of the coating disc 22.

[0032] All documents mentioned in the present invention are cited herein as references, just as if each document was individually cited as a reference. In addition, it should be understood that after reading the above teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0033] The above are only the preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims

1. An applicator for the clinical detection test of Treponema pallidum non-specific antibody, characterized in that, Comprising: A hollow main body handle (1), a rubber coating sleeve (2), and a spare injector (3); wherein, the hollow main body handle (1) includes a handle body (11), a handle piston rod (12), a liquid injection port (13), and a main body needle (14); the rubber coating sleeve (2) is integrally formed and includes an outer wrapping joint (21) and a coating disc (22); the liquid injection part (3) includes an independent spare syringe (31); the handle body (11) is in a cylindrical shape, with one end open for the handle piston rod (12) to retract and extend during operation, and the other end is provided with a needle mounting part (15), on which the main body needle (14) is mounted; a longitudinal slot (16) is axially formed on the side of the handle body (11) close to the open end of the cylinder, and a liquid injection port (13) with a protruding edge is provided at one end of the handle body (11) close to the main body needle (14), the liquid injection port (13) communicates with the outside, and threads are provided both inside and outside the protruding edge.

2. The coater according to claim 1, characterized in that, The longitudinal slot (16) and the liquid injection port (13) are arranged diagonally in the radial direction, and the longitudinal slot (16) and the liquid injection port (13) are respectively located on both sides of the handle body (11).

3. The coater according to claim 1, wherein, The handle piston rod (12) is installed inside the handle body (11), and the handle piston rod (12) includes a piston (121), a piston rod (122), and a plug (123). The piston (121) and the plug (123) are connected to both ends of the piston rod (122), and a convex knob (124) is fixedly provided on the piston rod (122), and the convex knob (124) can axially slide in the longitudinal slot (16).

4. The coater according to claim 1, characterized in that The liquid injection port (13) includes a concave inner cover (131) with holes, a rubber top plug (132), and an outer cover (133). The concave inner cover (131) is threadedly installed inside the protruding edge of the liquid injection port (13), the rubber top plug (132) is installed inside the concave inner cover (131), and the outer cover (133) is screwed onto the thread on the protruding edge.

5. The coater according to claim 1, characterized in that, There is a hole on the outer wrapping joint (21) at one end of the rubber coating sleeve (2), which is sleeved on the outer cover (133) of the liquid injection port (13) of the protruding edge of the handle body (11) to prevent the rubber coating sleeve (2) from falling off the handle body (11).

6. The coater according to claim 1, characterized in that, The rubber top plug (132) is for preventing liquid leakage, and the outer cover (133) is for preventing the rubber top plug (132) from being extruded and falling off.

7. The coater according to claim 1, characterized in that, The concave inner cover (131) is provided with an injection hole, the outer edge of the concave inner cover (131) is stuck outside the protruding edge, and the body of the concave inner cover (131) is at a certain distance from the inner arc surface of the cylinder of the handle body 11 to prevent interference when the piston (121) slides down or up.

8. The coater according to claim 1, characterized in that, One end of the rubber coating sleeve (2) has a hole on the outer connecting joint (21), which is sleeved on the outer cover (133) of the liquid injection port (13) on the protruding edge of the handle body (11). The coating disc (22) is fixedly arranged at the other end of the outer connecting joint (21). The axis of the outer connecting joint (21) is inclined at 45° to the plane where the coating disc (22) is located. The coating surface of the coating disc (22) is a horizontal plane, and the center of the coating disc (22) is provided with a liquid outlet hole.

9. The coater according to claim 1, characterized in that, The handle body (11) drives the piston (121) by sliding the convex button (124) upward to suck the liquid into the main body needle head (14); the spare syringe (31) injects the liquid to be applied into the handle body (11) by unscrewing the outer cover (133), pulling out the rubber top plug (132), and inserting it into the injection hole on the inner concave cover (131).

10. The coater according to claim 1, characterized in that, The plug (123) of the handle piston rod (12) has a dust-proof function. Sliding the convex button (124) downward drives the piston (121) to inject liquid into the rubber coating sleeve (2), and the coating liquid flows out from the liquid outlet hole at the center of the coating disc (22).

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