Detection and analysis equipment and control method thereof

Abstract

The invention discloses detection and analysis equipment and a control method thereof, and relates to the technical field of detection. The detection and analysis equipment comprises a shell, a sampler, a controller, and an identification code scanner, a magnetic stirring device, a position sensor, a temperature control module and an optical detection module which are arranged in the shell and electrically connected with the controller respectively; a test channel is arranged in the shell; the sampler is inserted into the test channel, and an identification code area and a light-transmitting area are arranged on the sampler; the sampler is used for containing a to-be-detected sample and a detection reagent; a scanning port of the identification code scanner faces the identification code area; the magnetic stirring device is arranged at the bottom of the sampler; the position sensor is arranged in the test channel; the temperature control module is arranged on the periphery of the test channel; the optical detection modules are arranged on the two sides of the sampler light-transmitting area. The detection and analysis equipment provided by the invention can realize home detection and improve the accuracy and reliability of autonomous detection.

Description

Technical Field

[0001] The present application relates to the field of detection technology, and in particular to a detection and analysis device suitable for home detection and a control method thereof. Background Art

[0002] Traditional medical tests typically need to be performed in medical institutions, but with the continued growth of the population, the burden on medical resources is also increasing. To address this, home testing technologies have been developed to reduce the medical burden. Currently, immunochromatographic test strips are widely used in home testing due to their simple detection process and low cost. Specifically, immunochromatographic test strips are a rapid detection technology based on immune reactions, which produces visual results by binding specific antibodies to the test substance. Although the self-testing process based on immunochromatographic test strips is much simpler than operating a dedicated instrument, when users use test strips for self-testing, they still need to strictly adhere to specific steps and time limits. For example, sample collection, processing, and test strip immersion time all need to be precisely controlled. When performing self-testing based on immunochromatographic test strips, any operational deviations can lead to inaccurate test results. As can be seen, the actual operation process of the test strips still has certain difficulties and complexities, making it difficult to guarantee the accuracy and reliability of self-testing. Summary of the Invention

[0003] The present application aims to solve at least one of the technical problems existing in the prior art. To this end, the present application proposes a detection and analysis device and a control method thereof, which can simplify the operation process of self-detection at home and improve the accuracy and reliability of self-detection.

[0004] In a first aspect, an embodiment of the present application provides a detection and analysis device, comprising: a housing, a sampler, an identification code scanner disposed in the housing, a magnetic stirring device, a position sensor, a temperature control module, an optical detection module, and a controller; wherein,

[0005] A test channel is provided in the housing;

[0006] The sampler is inserted into the test channel, and an identification code area and a light-transmitting area are provided on the sampler; the sampler is used to hold the sample to be tested and the detection reagent;

[0007] The scanning port of the identification code scanner faces the identification code area;

[0008] The magnetic stirring device is arranged at the bottom of the sampler;

[0009] The position sensor is arranged in the test channel;

[0010] The temperature control module is arranged on the periphery of the test channel;

[0011] The optical detection module is arranged at the bottom of the test channel and on both sides of the sampler;

[0012] The controller is electrically connected to the identification code scanner, the magnetic stirring device, the position sensor, the temperature control module, and the optical detection module respectively.

[0013] In a second aspect, an embodiment of the present application provides a control method for a detection and analysis device, which is applied to the controller of the detection and analysis device described in any one of the embodiments of the first aspect, wherein the detection and analysis device further includes: a housing, a sampler, a QR code scanner disposed in the housing, a magnetic stirring device, a position sensor, a temperature control module, and an optical detection module; the method includes:

[0014] When receiving the in-position signal emitted by the position sensor, it is determined that the sampler is inserted into the test channel and is located at the target test position, the QR code scanner is controlled to scan the QR code area to obtain the QR code information, and the heating control information, the detection reaction time, the reagent information, and the test control information are obtained from the QR code information;

[0015] After the incubation is completed, the magnetic stirring device is controlled to start and the sample to be tested and the detection reagent in the sampler are stirred and shaken;

[0016] controlling the temperature control module to perform a first heating process according to the heating control information, so that the ambient temperature in the instrument where the sampler is located reaches a target reaction temperature, so that the sample to be tested in the sampler and the detection reagent undergo a chemical reaction at the target reaction temperature to obtain a reactant;

[0017] According to the test control information, the optical detection module is controlled to start, and the reactant in the sampler is optically detected through the light-transmitting area to obtain an electrical detection signal;

[0018] The electrical detection signal is analyzed according to the reagent information to obtain a detection result.

[0019] In a third aspect, an embodiment of the present application provides a controller comprising at least one processor and a memory for communicating with the at least one processor; the memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor so that the at least one processor can execute the control method of the detection and analysis equipment as described in any one of the embodiments of the first aspect.

[0020] In a fourth aspect, an embodiment of the present application provides a computer-readable storage medium, which stores computer-executable instructions, and the computer-executable instructions are used to enable a computer to execute the control method of the detection and analysis equipment as described in any one of the embodiments of the first aspect.

[0021] The embodiments of the present application include: the detection and analysis equipment includes: a shell, a sampler, an identification code scanner arranged in the shell, a magnetic stirring device, a position sensor, a temperature control module, an optical detection module, and a controller; wherein, a test channel is arranged in the shell; the sampler is inserted in the test channel, and an identification code area and a light-transmitting area are arranged on the sampler; the sampler is used to hold the sample to be tested and the detection reagent; the scanning port of the identification code scanner faces the identification code area; the magnetic stirring device is arranged at the bottom of the sampler; the position sensor is arranged in the test channel; the temperature control module is arranged on the periphery of the test channel; the optical detection module is arranged at the bottom of the test channel and on both sides of the sampler; the controller is electrically connected to the identification code scanner, the magnetic stirring device, the position sensor, the temperature control module, and the optical detection module, respectively. When using the detection and analysis equipment for detection, the controller is used to: when receiving the in-place signal emitted by the position sensor, determine that the sampler is inserted in the test channel and is located at the target test position, first, control the identification code scanner to scan the identification code area, obtain the identification code information, and obtain the heating control information, detection reaction time, reagent information, and test control information from the identification code information; secondly, after the incubation is completed, control the magnetic stirring device to start, and stir and shake the sample to be tested and the detection reagent in the sampler; then, control the temperature control module to perform a first heating treatment according to the heating control information, so that the ambient temperature in the instrument where the sampler is located reaches the target reaction temperature, so that the sample to be tested in the sampler and the detection reagent undergo a chemical reaction at the target reaction temperature to obtain a reactant; finally, control the optical detection module to start according to the test control information, and optically detect the reactant in the sampler through the light-transmitting area to obtain an electrical detection signal; analyze the electrical detection signal according to the reagent information to obtain the detection result. Without the need for complex testing operations, the sampler containing the sample to be tested and the test reagent is inserted into the test channel, and the detection and analysis equipment can automatically detect the reactants obtained from the chemical reaction and obtain the test results, thereby improving the accuracy and reliability of the autonomous detection. In other words, the embodiments of the present application can simplify the operation process of the self-detection and improve the accuracy and reliability of the autonomous detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 This is a schematic diagram of the cross-sectional structure of a detection and analysis device provided in one embodiment of the present application;

[0023] Figure 2 This is a schematic diagram of electrical control connections of a detection and analysis device provided in one embodiment of the present application;

[0024] Figure 3 Schematic diagram of the arrangement of two cuvettes provided in one embodiment of the present application;

[0025] Figure 41 is a schematic diagram of the specific structure of three cuvettes provided in one embodiment of the present application;

[0026] Figure 5 Schematic diagram of the arrangement of four cuvettes provided in one embodiment of the present application;

[0027] Figure 6 This is a schematic diagram of a group of liquid storage tubes, capillary elements, and a pushing device corresponding to a cuvette in a sampler provided by an embodiment of the present application;

[0028] Figure 7A This is a structural diagram of a cuvette and an optical detection module provided in one embodiment of the present application;

[0029] Figure 7B is a structural schematic diagram of a cuvette and an optical detection module provided in another embodiment of the present application;

[0030] Figure 8A This is a schematic diagram of a first light path of a cuvette and an optical detection module provided in one embodiment of the present application;

[0031] Figure 8B This is a schematic diagram of a second optical path of a cuvette and an optical detection module provided in one embodiment of the present application;

[0032] Figure 9A Schematic diagram of a third optical path of a cuvette and an optical detection module provided in one embodiment of the present application;

[0033] Figure 9B 1 is a fourth optical path schematic diagram of a cuvette and an optical detection module provided in one embodiment of the present application;

[0034] Figure 10 Schematic diagram of the structure of two cuvettes and an optical detection module provided in one embodiment of the present application;

[0035] Figure 11A This is a schematic diagram of a first light path of two cuvettes and an optical detection module provided in one embodiment of the present application;

[0036] Figure 11B Schematic diagram of a second optical path of two cuvettes and an optical detection module provided in one embodiment of the present application;

[0037] Figure 12 Schematic diagram of the third optical path of two cuvettes and the optical detection module provided in one embodiment of the present application;

[0038] Figure 13 Schematic diagram of a fourth optical path of two cuvettes and an optical detection module provided in one embodiment of the present application;

[0039] Figure 14Schematic diagram of the fifth optical path of two cuvettes and the optical detection module provided in one embodiment of the present application;

[0040] Figure 15 Schematic diagram of the structure of three cuvettes and an optical detection module provided in one embodiment of the present application;

[0041] Figure 16 This is a schematic diagram of a first optical path of three cuvettes and an optical detection module provided in one embodiment of the present application;

[0042] Figure 17 Schematic diagram of a second optical path of three cuvettes and an optical detection module provided in one embodiment of the present application;

[0043] Figure 18 Schematic diagram of the third optical path of three cuvettes and the optical detection module provided in one embodiment of the present application;

[0044] Figure 19 Schematic diagram of the fourth optical path of three cuvettes and the optical detection module provided in one embodiment of the present application;

[0045] Figure 20 Schematic diagram of the fifth optical path of three cuvettes and the optical detection module provided in one embodiment of the present application;

[0046] Figure 21 Schematic diagram of the structure of four cuvettes and an optical detection module provided in one embodiment of the present application;

[0047] Figure 22 This is a schematic diagram of a first optical path of four cuvettes and an optical detection module provided in one embodiment of the present application;

[0048] Figure 23 Schematic diagram of the second optical path of four cuvettes and an optical detection module provided in one embodiment of the present application;

[0049] Figure 24 Schematic diagram of the third optical path of four cuvettes and the optical detection module provided in one embodiment of the present application;

[0050] Figure 25 Schematic diagram of a fourth optical path of four cuvettes and an optical detection module provided in one embodiment of the present application;

[0051] Figure 26 Schematic diagram of the structure of the test channel and magnetic stirring device provided in one embodiment of the present application;

[0052] Figure 27 This is a schematic structural diagram of a detection and analysis device for placing two cuvettes provided in one embodiment of the present application;

[0053] Figure 28is a schematic structural diagram of a display assembly provided in one embodiment of the present application;

[0054] Figure 29 This is a schematic structural diagram of a detection and analysis device for placing three cuvettes arranged in an inverted triangle, provided in one embodiment of the present application;

[0055] Figure 30 This is a schematic structural diagram of a detection and analysis device for placing four cuvettes provided in one embodiment of the present application;

[0056] Figure 31 This is a schematic structural diagram of a detection and analysis device provided by an embodiment of the present application that does not include a display component;

[0057] Figure 32 This is a flow chart of a control method for a detection and analysis device provided in one embodiment of the present application;

[0058] Figure 33 is a schematic diagram of a first analysis curve provided in one embodiment of the present application;

[0059] Figure 34 is a schematic diagram of a third analysis curve provided in one embodiment of the present application;

[0060] Figure 35 This is a schematic diagram of the hardware structure of the controller provided in one embodiment of the present application. DETAILED DESCRIPTION

[0061] In order to make the purpose, technical solutions and advantages of this application more clear, this application is further described in detail below with reference to the accompanying drawings and embodiments.

[0062] It should be understood that in the description of this application, descriptions of orientations, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, they cannot be understood as limitations on this application.

[0063] It should be noted that although a logical order is shown in the flowchart in the description of this application, in some cases, the steps shown or described may be performed in an order different from that in the flowchart. In the description of this application, "several" means one or more, and "more" means two or more. The description of "first" and "second" is only used to distinguish technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0064] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this application pertains. The terms used herein are for the purpose of describing the embodiments of this application only and are not intended to limit this application.

[0065] The embodiments of the present application provide a detection and analysis device, a control method for the detection and analysis device, a controller and a computer-readable storage medium. The detection and analysis device of the present application includes: a shell, a sampler, a controller, an identification code scanner arranged in the shell and electrically connected to the controller respectively, a magnetic stirring device, a position sensor, a temperature control module, and an optical detection module; a test channel is arranged in the shell; the sampler is inserted in the test channel, and an identification code area and a light-transmitting area are provided on the sampler; the sampler is used to hold the sample to be tested and the detection reagent; the scanning port of the identification code scanner faces the identification code area; the magnetic stirring device is arranged at the bottom of the sampler; the position sensor is arranged in the test channel; the temperature control module is arranged on the periphery of the test channel; the optical detection module is arranged at the bottom of the test channel and on both sides of the sampler; the detection and analysis device provided by the present application can simplify the operation process of self-detection, obtain quantitative detection results, and improve the portability and reliability of autonomous detection.

[0066] The embodiments of the present application are further described below with reference to the accompanying drawings.

[0067] First, as Figure 1 and Figure 2 As shown, the embodiment of the present application provides a detection and analysis device 1000, comprising: a housing 200, a sampler 100, an identification code scanner 300 arranged in the housing 200, a magnetic stirring device 400, a position sensor 500, a temperature control module 600, an optical detection module 700, and a controller 800; wherein a test channel 210 is provided in the housing 200; the sampler 100 is inserted into the test channel 210, and an identification code area and a light-transmitting area are provided on the sampler 100; the sampler 100 is used to hold the sample to be tested and the test sample agent; the scanning port of the identification code scanner 300 faces the identification code area; the magnetic stirring device 400 is arranged at the bottom of the sampler 100; the position sensor 500 is arranged in the test channel 210; the temperature control module 600 is arranged on the periphery of the test channel 210; the optical detection module 700 is arranged at the bottom of the test channel 210 and on both sides of the sampler 100; the controller 800 is electrically connected to the identification code scanner 300, the magnetic stirring device 400, the position sensor 500, the temperature control module 600, and the optical detection module 700, respectively.

[0068] Specifically, the shell 200 is used to accommodate and protect the various modules and devices inside. This application does not impose specific restrictions on the shape and material of the shell 200. The sampler 100 is used to collect samples to be tested and to hold samples to be tested and detection reagents, providing a reaction place for the samples to be tested and the detection reagents to undergo biochemical reactions. The identification code scanner 300 is used to scan the identification code area of the sampler 100 to obtain identification code information, laying the foundation for subsequent heating and heat preservation treatment, detection and analysis. The magnetic stirring device 400 is used to stir and shake the samples to be tested and the detection reagents in the sampler 100, so that the samples to be tested and the detection reagents are fully in contact and react, which is conducive to improving the accuracy of the detection.

[0069] Specifically, the position sensor 500 is used to determine whether the sampler 100 has reached the target test position. When the position sensor 500 detects that the sampler 100 has reached the target test position, it will send an in-position signal to the controller 800 to prompt the controller 800 that the sampler 100 is inserted in the test channel 210 and is located at the target test position; when the position sensor 500 does not detect that the sampler 100 has reached the target test position, it will not send an in-position signal or send an out-of-position signal. Specifically, the position sensor 500 can adopt a photoelectric sensor, an ultrasonic ranging sensor, a visual sensor, etc., and designers can choose different types of position sensors 500 according to actual needs. Therefore, this application does not impose specific restrictions on the type of position sensor 500 used.

[0070] Specifically, the temperature control module 600 is used to detect the ambient temperature of the instrument in which the sampler 100 is located in real time, and to perform a heating process under the control of the controller 800 so that the ambient temperature of the instrument in which the sampler 100 is located reaches the target reaction temperature. It can be understood here that the main purpose is to ensure that the biochemical reaction is carried out at the optimal temperature. For example, antibody-antigen binding requires sufficient time to reach equilibrium. Specifically, for example, the antibody and antigen are incubated at 37°C to ensure specific binding.

[0071] Specifically, the optical detection module 700 is used to perform optical detection on the light-transmitting area in the sampler 100 , convert the collected optical signal into an electrical detection signal, and send the electrical detection signal to the controller 800 .

[0072] Specifically, the controller 800 is used to execute the control method of the detection and analysis equipment 1000 provided in the embodiment of the present application. There is no need to perform complicated detection operations. The sampler 100 containing the sample to be tested and the detection reagent is inserted into the test channel 210. The detection and analysis equipment 1000 can automatically detect the reactants obtained by the chemical reaction and obtain the detection results, thereby improving the accuracy and reliability of autonomous detection.

[0073] The detection and analysis device 1000 provided in the embodiment of the present application can simplify the operation process of self-detection. More importantly, it is miniaturized in design, easy to carry, and suitable for home detection.

[0074] According to some embodiments of the present application, the sampler 100 includes at least one cuvette (n≥1), and the cuvette and the optical detection module 700 are matched and arranged; wherein, when the number of cuvettes n=1, the cuvettes are arranged in arbitrary positions; when the number of cuvettes n=2, the cuvettes are arranged linearly; and when the number of cuvettes n≥3, they are arranged linearly or in a two-dimensional geometric or grid arrangement.

[0075] According to some embodiments of the present application, Figure 3 As shown, each cuvette 110 is provided with a communicating accommodating chamber 111 and a reaction chamber 112, and the side wall of the reaction chamber 112 is light-transmissive; the reaction chamber 112 is used to mix the liquid to be tested and the detection reagent, to cause a biochemical reaction, and to contain the reactants produced by the chemical reaction.

[0076] It is understood that each cuvette 110 in the sampler 100 is provided with a communicating accommodating chamber 111 and a reaction chamber 112, the reaction chamber 112 contains the first reagent, and the side wall of the reaction chamber 112 is light-transmissive to facilitate subsequent use of the optical detection module 700 (see Figure 7A and Figure 7B ) Capture the light signals before and after the biochemical reaction for detection and analysis.

[0077] like Figure 6 As shown, the sampler 100 also includes: a liquid storage tube 120, a capillary element 130, and a pushing device 140. Among them, the liquid storage tube 120 is detachably connected to the accommodating chamber 111, and the opening of the liquid storage tube 120 is provided with a sealing film, and the liquid storage tube 120 is used to hold the second reagent. The capillary element 130 is used to collect the sample to be tested. The pushing device 140 includes a pushing cylinder, which is detachably connected to the capillary element 130; it is used to push the capillary element 130 toward the liquid storage tube 120, so that the sampling head of the capillary element 130 pierces the sealing film, so that the second reagent and the sample to be tested flow into the reaction chamber 112. It can be understood that in the sampler 100, each cuvette 110 is correspondingly configured as follows Figure 12 A set of liquid storage tubes 120 , capillary elements 130 , and pushing devices 140 are shown.

[0078] It is understandable that the detection reagent includes: a first reagent in the reaction chamber 112 and a second reagent in the liquid storage tube 120 .

[0079] Specifically, see Figure 6The method of using the sampler 100 is as follows: when the pushing cylinder and the capillary element 130 in the pushing device 140 are in a disassembled state, the capillary action of the sampling head of the capillary element 130 is used to collect the sample to be tested, which eliminates the complicated sampling operation steps and reduces the difficulty of sampling; after the collection is completed, the capillary element 130 is connected to the pushing cylinder of the pushing device 140, the capillary element 130 is sent into the accommodating cavity 111, and the pushing cylinder is pushed to move the capillary element 130 toward the liquid storage tube 120, so that the sampling head pierces the sealing membrane of the liquid storage tube 120, so that the second reagent and the sample to be tested flow into the reaction chamber 112 and produce a chemical reaction with the first reagent, and the detection is achieved without the need for complicated detection operations, thereby ensuring the accuracy and reliability of home self-testing. Therefore, the sampler 100 provided by the present application can provide simpler sampling and detection operations to ensure the accuracy and reliability of home self-testing.

[0080] It should be noted here that in the context of this application, the sampler refers to an integral component used to collect samples to be tested and to perform reactions. The test channel is a cavity that matches the sampler and accommodates the sampler. The test channel here is also an integral component, and the sub-channels correspond to the various cuvettes that form the sampler as a whole. For example, when there is only one cuvette constituting the sampler, then the main component of the sampler is a cuvette, and there is only one sub-channel corresponding to the test channel. When there are two cuvettes constituting the sampler, there are two corresponding test sub-channels, and these two test sub-channels constitute the entirety of the test channel, and so on. Of course, it is understandable that the sampler also includes other markings such as fool-proof design elements, and capillary elements and push rods that match the cuvettes. For example, Figure 3 The two cuvettes in the sampler constitute the sampler. Figure 4 The three cuvettes in the sampler constitute the sampler. Figure 5 The four cuvettes in the sampler constitute the sampler, and the sampler also includes Figure 6 The pushing device, capillary element, and liquid storage tube are shown.

[0081] It is understood that the arrangement of the sampler cuvettes can be seen in Figure 3 、 Figure 4 and Figure 5 For example, when the number of cuvettes n=1, the cuvettes are arranged at random positions, when the number of cuvettes n=2, the cuvettes are arranged linearly, and when the number of cuvettes n≥3, the cuvettes are arranged linearly or in a two-dimensional geometric or grid arrangement, for example Figure 3 The two cuvettes are arranged in parallel. Figure 4 The three cuvettes are distributed in a triangle. Figure 5 The four cuvettes are arranged in a parallelogram.

[0082] It should also be noted that the cuvette mentioned in the context of this application is not the cuvette in the prior art, but is specially designed according to the needs of the optical detection module and biochemical reactions. For details, please refer to the explanation in the context of this application. It should also be noted that the matching setting of the cuvette and the optical detection module does not necessarily mean that the number of cuvettes and the number of optical detection modules are completely equal, nor does it necessarily mean that the number of test channels of the cuvette and the number of optical detection modules are completely equal. It should be understood that what should be referred to here is that the number of test sub-channels corresponding to the cuvette has corresponding detection channels. It is understandable that the optical detection module mainly includes a light source exciter and a signal receiver, and of course may also include other components. Other possible components are not described here. Therefore, the matching setting of the cuvette and the optical detection module here should be understood in a broad sense.

[0083] According to some embodiments of the present application, Figure 3 and Figure 27 As shown, the sampler 100 includes at least two cuvettes 110, which are arranged side by side. On the plane defined by the X-axis and the Y-axis, the two cuvettes 110 can be arranged side by side horizontally along the X-axis, side by side along the Y-axis, or arranged in any direction parallel to the plane defined by the X-axis and the Y-axis.

[0084] See for example Figure 7A 、 Figure 7B 、 Figure 8A 、 Figure 8B 、 Figure 9A and Figure 9B , it should be noted here that, Figure 8A 、 Figure 8B 、 Figure 9A and Figure 9B (Including subsequent Figure 11A 、 Figure 11B 、 Figures 12 to 14 、 Figures 16-20 and Figures 22 to 25 ) is shown by a circle in which the cuvette 110 or the test sub-channel is shown, by a triangle in which the light source generator 710 is shown, and by a square in which the optical signal receiver 720 is shown. The shapes and sizes in the drawings do not mean any limitation on the actual structure of the present application, but are only for the convenience of explaining the matching setting of the cuvette and the optical path and the process of receiving the optical signal.

[0085] Specifically, see Figure 7A 、 Figure 7B 、 Figure 8A 、 Figure 8BWhen the number of cuvettes is one, the optical detection module can be provided with one light source generator for emitting excitation light, and one light signal receiver for receiving light signals. In this case, the light source generator 710 and the light signal receiver 720 may be distributed on both sides of the cuvette and in a straight line, for example Figure 7A and Figure 9A In the embodiment, the light source generator 710 and the light signal receiver 720 are connected to Figure 7A and Figure 9A The light transmission area of the cuvette 110 shown in FIG. 1 is in a straight line. It is known to those skilled in the art that light generally propagates along a straight line. In this case, the light source generator 710 and the light signal receiver 720 are aligned with each other. Figure 7A and Figure 9A The straight line formed by the light-transmitting area of the cuvette 110 shown in the figure is perpendicular to the horizontal plane. For example, in the case of being perpendicular to the horizontal plane, the direction vector is (0, 0, ± 1), which is perpendicular to the horizontal plane (XY plane) and parallel to the Z axis. It can be understood that the above situation is a vertical arrangement situation. There is also a horizontal arrangement situation, which is not shown in the figure, that is, the light source generator 710 and the optical signal receiver 720 are arranged horizontally. Figure 7A and Figure 9A The straight line formed by the light-transmitting area of the cuvette 110 shown in FIG is parallel to the horizontal plane. For the case where the straight line is parallel to the horizontal plane, the direction vector is (a, b, 0), which is parallel to the horizontal plane and projected onto the XY plane. The positions of the corresponding light source generator 710 and the optical signal receiver 720 can be interchanged, and this application does not impose specific limitations on this.

[0086] Continuing, see Figure 7B 、 Figure 8A and Figure 8B At this time, the light source generator 710 and the optical signal receiver 720 are connected to Figure 7B 、 Figure 8A and Figure 8B The light-transmitting area of the cuvette 110 shown in the figure is still on a straight line, but is non-orthogonal to the horizontal plane. It can be understood as an oblique straight line, that is, it is neither parallel nor perpendicular to the horizontal plane, the direction vector satisfies (a, b, c) and c≠0, and the angle θ formed with the horizontal plane satisfies 0°<θ<90°.

[0087] The above is a case where the light source generator 710 and the light signal receiver 720 are distributed on both sides of the cuvette 110. Another case is that when the number of cuvettes is 1, the light source generator 710 and the light signal receiver 720 are on the same side of the cuvette 110, see Figure 9BIn this case, an optical reversing device 730, specifically a beam splitter element such as a prism, is added to the optical path between the cuvette 110 and the optical signal receiver 720. This allows the optical signal from the cuvette 110 to reach the optical signal receiver 720 through reflection or transmission. Thus, when n = 1, the matching arrangement of the cuvette 110 and the optical detection module 700 means that the number of cuvettes 110 and the number of optical detection modules 700 are equal.

[0088] See also Figure 10-14 When the number of cuvettes is 2, it means that the sampler 100 corresponding to the cuvette 110 has 2 test channels. Therefore, the optical detection module can be provided with 2 light source generators and 2 optical signal receivers, that is, each test channel corresponds to a set of light source generators 710 and optical signal receivers 720, and the light source generators 710 and optical signal receivers 720 are located on both sides of the test channel and in a straight line, see Figure 10 、 Figure 11A At this time, the light source generator 710 and the light signal receiver 720 are located on a straight line parallel to the Z axis and perpendicular to the horizontal plane with the cuvette 110, and the two test sub-channels (or cuvettes) of the sampler 100 are horizontally parallel (see Figure 10 and Figure 11A ) or arranged in parallel vertically (see Figure 12 ). Continue to see Figure 11B At this time, the light source generator 710 and the light signal receiver 720 are located on a straight line parallel to the Z axis and perpendicular to the horizontal plane with the cuvette 110, but the two test sub-channels (or cuvettes) of the sampler 100 are neither horizontally nor vertically parallel, but are staggered.

[0089] There is another case where the number of cuvettes is 1, and the light source generator 710 and the light signal receiver 720 can also be located on the same side of the test channel at the same time. Here, optical elements such as prisms are added. No further details are given here. This case can be applied to subsequent cases such as n=3, n=4, etc. In addition, there is another case where, see Figure 13 , there may be only one light source generator 710, but the light source generator 710 is a tunable light source generator, that is, the light source generator 710 can emit excitation light of different wavelengths to illuminate the test channels. The number of optical signal receivers 720 corresponds to the number of test channels, while the number of light source generators 710 is only one, so they are not completely corresponding; see Figure 14It is also possible that the number of optical signal receivers 720 is one, but two light source generators are provided. In this way, each light source generator emits excitation light of different wavelengths corresponding to different test channels, but an optical reversing device (such as a spectrometer) is provided on the receiving optical path so that light signals at different excitation wavelengths arrive at the receiver at different times or the light signal of the target test channel is collected through a filter. In this way, there will be two light source generators and one optical signal receiver. Of course, it is also understandable that there may be only one tunable light source generator and one optical signal receiver with an additional spectrometer, which are not shown in the drawings. Therefore, at this time, the number of optical detection modules does not correspond to the number of cuvettes, nor does it correspond to the number of test channels.

[0090] According to some embodiments of the present application, see Figures 15-20 The sampler 100 includes at least three cuvettes 110, which are arranged in one or more rows, and the cuvettes 110 in each row are arranged in parallel. Figure 15 、 Figure 19 and Figure 20 As shown, when the number of the cuvettes 110 is three, the three cuvettes 110 are arranged in a triangle. It is understandable that the three cuvettes 110 can be arranged in an equilateral triangle or an inverted triangle. Figure 16 , the three cuvettes 110 can be arranged vertically in a straight line, see Figure 17 The three cuvettes 110 can also be arranged horizontally in a straight line, see Figure 18 , the three cuvettes 110 can also be distributed in three rows, but the center point line of the three cuvettes presents an inclined straight line. Specifically, the detection and analysis equipment for placing three cuvettes arranged in an equilateral triangle is as follows: Figure 28 As shown; the detection and analysis equipment for placing three cuvettes arranged in an inverted triangle is as shown Figure 29 shown.

[0091] It is understood that each side of the triangle in the triangular arrangement can be considered to comprise a row of cuvettes 110. Adjacent cuvettes 110 are fixedly connected in parallel and side by side. It is understood that the cuvettes 110 can be arranged compactly to fully utilize the space within the housing 200. The distance between two side-by-side cuvettes can also be determined based on actual circumstances.

[0092] It is understandable that when the sampler 100 in the context of this application involves multiple cuvettes 110, the size, inner diameter, and volume capacity of the cuvettes 110 need to be specially designed according to the requirements of the sample to be tested and the detection reagent contained therein, which will not be repeated here.

[0093] According to some embodiments of the present application, see Figure 21-Figure 25 When the number of the cuvettes 110 is four and they are arranged in multiple rows, the cuvettes 110 between two adjacent rows are arranged in a staggered manner. Specifically, Figure 21 、 Figure 25 、 Figure 30 As shown, when there are four cuvettes 110 and they are arranged in two rows, with two cuvettes 110 in each row, the cuvettes 110 are staggered and arranged in pairs between two adjacent rows; so that an optical detection module 700 is matched with each cuvette 110, and the optical detection module 700 can detect the corresponding cuvette 110. In another embodiment, the following can also be set: Figure 24 As shown, when the number of cuvettes 110 is four and they are arranged in two rows, one row has three cuvettes arranged side by side, and the other row has one cuvette arranged alone, and the cuvettes in the independent row are staggered and arranged between any two adjacent cuvettes in the other row. Figure 22 , the four cuvettes are arranged in a straight line in the longitudinal direction. Another possibility is to see Figure 23 , the four cuvettes are distributed in a straight line in the horizontal direction.

[0094] According to some embodiments of the present application, the number of light source generators 710 is equal to the number of cuvettes 110, and there is at least one light signal receiver 720. Specifically, the optical detection module 700 is used to detect the chemical reaction in the cuvette 110. By capturing the light signals before and after the chemical reaction and analyzing them, the optical detection module 700 achieves automatic detection, ensuring the accuracy and reliability of self-monitoring at home.

[0095] Specifically, the light source generator 710 can emit a first light signal and irradiate the first light signal to the reaction chamber 112, and the light signal receiver 720 can receive a second light signal emitted after passing through the cuvette 110, so that the controller 800 can subsequently analyze the light signal to obtain a detection result.

[0096] It is understood that the number of light source generators 710 matches the number of cuvettes 110, and the light source output port of the light source generator 710 is aligned with the light-transmitting area of the cuvette 110 to emit excitation light to excite the sample and detection reagent therein. The light source generator 710 can emit excitation light of different wavelengths to the corresponding light-transmitting area of the cuvette 110. Therefore, this application does not impose specific restrictions on the number of light source generators 710 or the type of the first optical signal sent by the light source generator 710.

[0097] It is understood that the number of optical signal receivers can match the number of cuvettes 110, so that the corresponding second optical signals emitted from the cuvettes 110 can be received and captured, thereby enabling the detection and analysis of specific substances in the sample. The number of light source generators 710 and optical signal receivers 720 matches the number of cuvettes 110, ensuring that each cuvette 110 can receive uniform and independent illumination and signal reception. Therefore, this application does not impose any specific restrictions on the number of optical signal receivers. Specifically, the number of optical signal receivers 720 can also be set to only one. When only one optical signal receiver 720 is provided or the number of optical signal receivers 720 is less than the number of cuvettes 110, an optical reversing device 730 capable of changing the direction of light propagation is provided between each cuvette 110 and the target optical signal receiver 720, corresponding to each cuvette 110. The optical reversing device 730 is used to change the propagation direction of the optical signal emitted from the cuvette 110 so that the optical signal emitted from the cuvette 110 is incident on the optical signal receiver 720. The location and orientation of the optical reversing device 730 can be adjusted based on actual circumstances. Specifically, the optical reversing device 730 can be a reflector, and this application does not impose any specific restrictions on the type of optical reversing device employed. Furthermore, this application can adjust the number of light source generators 710 based on the actual number of cuvettes. There must be at least one optical signal receiver 720, and therefore, this application does not impose any specific restrictions on the number of optical signal receivers 720 or the number of optical signal receivers 720.

[0098] It is understandable that when the sampler 100 includes different numbers of cuvettes 110 and different arrangements of the cuvettes 110, the corresponding configuration of the optical detection module 700 will also be different. Further, the corresponding configuration of the optical detection module 700 will be described based on the number of cuvettes.

[0099] Specifically, when there is only one cuvette, a light source generator 710 and a light signal receiver 720 are arranged on both sides of the cuvette. Figure 6 As shown, a light source generator 710 and a light signal receiver 720 are provided for each cuvette 110; the light signal propagation path between the corresponding set of light source generators 710 and light signal receivers 720 is as shown in FIG. Figure 6 As shown by the dotted line. Figure 25 It can be seen that when three, four, or more cuvettes 110 are arranged side by side, a light source generator 710 and a light signal receiver 720 are provided for each cuvette 110. The positions of the corresponding light source generator 710 and the corresponding light signal receiver 720 can be interchanged, and this application does not impose any specific restrictions on this.

[0100] Specifically, if Figure 19 and Figure 20 As shown, when there are three cuvettes 110 and the three cuvettes 110 are arranged in a triangle, three light source generators 710 and three optical signal receivers 720 are correspondingly provided, wherein the emission wavelengths of the light source generators 710 at both ends are both 550 nm, and the emission wavelength of the middle emitter is 365 nm.

[0101] Specifically, if Figure 25 As shown, when there are four cuvettes 110 and they are arranged in two rows with two cuvettes in each row, the cuvettes 110 are staggered and arranged in the air between the two adjacent rows. Similarly, a light source generator 710 and a light signal receiver 720 are set corresponding to each cuvette 110. Figure 25 As shown; the corresponding optical signal propagation path between a group of light source generators 710 and optical signal receivers 720 is as shown Figure 25 Shown by dotted line.

[0102] Specifically, if Figure 23 and Figure 24 As shown, when there are four cuvettes 110 and they are arranged in two rows, one row has three cuvettes 110 arranged side by side, and the other row has one cuvette 110 arranged alone, and the cuvettes 110 in the row are staggered and arranged between any two adjacent cuvettes in the other row. Similarly, a light source generator 710 and a light signal receiver 720 are set corresponding to each cuvette 110. Figure 23 As shown; the corresponding optical signal propagation path between a group of light source generators 710 and optical signal receivers 720 is as shown Figure 23 Specifically, Figure 24 As shown, a group of light source generators 710 and light signal receivers 720 can also be arranged along an oblique line, and the specific light propagation direction is as follows: Figure 24 shown by the dotted line.

[0103] Specifically, refer to Figure 22-23When there are four cuvettes 110 arranged in a row, a light source generator 710 is provided on the same side of each cuvette 110. On the other side of the cuvette 110, a light signal receiver 720 is provided. Correspondingly, an optical reversing device 730 capable of changing the direction of light propagation is provided between each cuvette and the target light signal receiver 720. The optical reversing device 730 changes the direction of light propagation of the light signal emitted from the cuvette 110 so that the light signal emitted from the cuvette 110 is incident on the light signal receiver 720. The optical signal propagation path between the corresponding set of light source generators 710 and light signal receivers 720 is indicated by a dotted line. It will be appreciated that a single light signal receiver 720 can receive multiple light signals emitted from multiple cuvettes 110. As the number of cuvettes 110 increases, the number of light signal receivers 720 used can also be adaptively adjusted.

[0104] According to some embodiments of the present application, Figure 4 As shown, an identification code area 113 is provided on the side wall of the accommodating cavity 111 of at least one cuvette 110 .

[0105] Specifically, for example, an identification code is affixed to the identification code area 113, and the identification code information in the identification code area 113 can be obtained after scanning. If the detection reagents contained in multiple cuvettes 110 are exactly the same, the identification code information corresponding to each cuvette 110 can be integrated into a single identification code, thereby requiring only one identification code. Alternatively, corresponding identification codes can be generated for each cuvette 110 with different detection functions and affixed to the identification code area 113 of the corresponding cuvette 110, thereby facilitating accurate acquisition of the identification code information corresponding to each cuvette 110, and obtaining heating control information, detection reaction time, reagent information, test control information, etc. from the identification code information.

[0106] For example, when detecting kidney disease markers, the reagents in the three cuvettes 110 are fixed, so a single identification code containing three types of identification code information can be used. Scanning this identification code once can obtain the three types of identification code information, thereby improving scanning efficiency and information acquisition efficiency. Therefore, the embodiment of the present application does not impose a specific limitation on the number of identification code areas 113 provided.

[0107] According to some embodiments of the present application, Figure 4 and Figure 26As shown, an identification code window 212 is correspondingly provided on the side wall of the test channel 210, and the identification code window 212 is used to expose the identification code area 113. By providing the identification code window on the side wall of the test channel 210, the identification code area 113 on the cuvette 110 of the sampler 100 is exposed, so that the identification code scanner 300 can scan the identification code in the identification code area 113 to obtain the identification code information. In addition, the number of identification code windows 212 provided on the side wall of the test channel 210 is the same as the number of identification code areas 113 provided. Therefore, the embodiment of the present application does not impose any specific restrictions on the number of identification code windows 212 provided.

[0108] According to some embodiments of the present application, Figure 26 As shown, the test channel 210 includes sub-channels 211. The number of sub-channels 211 is the same as the number of cuvettes 110. The sub-channels 211 are arranged in the same manner as the arrangement of the cuvettes 110. One sub-channel 211 is used to place one cuvette 110. This facilitates fixing the sampler 100 for subsequent testing.

[0109] According to some embodiments of the present application, the detection and analysis device 1000 also includes: an annular guide rail fixedly connected to the shell 200, the annular guide rail is arranged around the test channel 210, the identification code scanner 300 is connected to the annular guide rail, and the identification code scanner 300 can move along the annular guide rail.

[0110] Specifically, when there are three cuvettes 110, the three cuvettes 110 are arranged in a triangle; and an identification code area 113 is provided on the side wall of the accommodating cavity 111 of each cuvette 110; the identification code scanner 300 can move along the annular guide rail to a preset scanning position, scan each identification code area 113 in turn, and obtain the identification code information on each cuvette 110 in turn; it can scan each identification code area 113 without omission, thereby improving the reliability of self-detection.

[0111] According to some embodiments of the present application, the optical detection module 700 includes: a light source generator 710 and an optical signal receiver 720 arranged opposite to each other, the light source generator 710 is arranged on one side of the reaction chamber 112 of the sampler 100; the optical signal receiver 720 is arranged on the other side of the reaction chamber 112 of the sampler 100.

[0112] It should be noted that when the sample to be tested and the detection reagent in the cuvette 110 undergo a chemical reaction under the action of the excitation light, a specific light signal will be generated, such as a change in fluorescence or absorption light or the color of the solution. The light signal receiver 720 can receive these light signals from the cuvette 110. The received light signal is analyzed by the controller 800 built into the detection and analysis device 1000, and qualitative or quantitative information of the sample can be obtained. In this way, the detection and analysis device 1000 of the embodiment of the present application is equipped with multiple light source generators 710 and at least one light signal receiver 720, which can perform optical detection on the mixed liquid after the reaction in multiple cuvettes 110 in parallel, thereby greatly improving the detection efficiency. The detection and analysis device 1000 can automatically perform light source excitation, receive light signals and process data, making the detection process simpler and more efficient.

[0113] In the present embodiment, a light source generator 710 and a light signal receiver 720 are provided, with each cuvette 110 being equipped with a light source generator 710. These light source generators 710 are capable of emitting excitation light of different wavelengths. Light of different wavelengths is suitable for exciting specific types of materials, thereby targeting the specific spectral properties of different chemical substances or biomarkers. For example, ultraviolet light can be used to excite specific fluorescent markers, or visible light can be used to detect certain color changes. Simultaneously, a light signal receiver 720 is positioned opposite or in an appropriate location on each cuvette 110. This light signal captures a second light signal emitted from the cuvette 110. This second light signal can be either reflected light or transmitted light. The second light signal is converted by the light signal receiver 720 into an electrical detection signal, which is then processed and analyzed by the controller 800 of the detection and analysis device 1000 to determine the information or concentration of the sample being tested. During operation, when a sample is placed in the cuvette 110, the light source generator 710 emits light of a specific wavelength that illuminates the light-transmitting area of the cuvette 110. This light passes through or reflects from the sample, where it is absorbed or scattered by molecules within the sample. The altered light is captured by the optical signal receiver 720 corresponding to the cuvette 110 and converted into an electrical detection signal. This electrical detection signal is then transmitted to the controller 800, which analyzes the sample's characteristics based on the intensity or wavelength changes of the optical signal.

[0114] According to some embodiments of the present application, Figure 26As shown, a first accommodating groove 213 and a second accommodating groove 214 are provided on the sidewall edge of the bottom of the test channel 210. The first accommodating groove 213 is used to accommodate the light source generator 710, and the second accommodating groove 214 is used to accommodate the optical signal receiver 720. The shape and size of the first accommodating groove 213 and the second accommodating groove 214 can be set according to the actual shape and size of the light source generator 710 and the optical signal receiver 720 used. The present application provides the first accommodating groove 213 and the second accommodating groove 214 to facilitate the installation and placement of the light source generator 710 and the optical signal receiver 720.

[0115] According to some embodiments of the present application, the magnetic stirring device 400 includes: magnetic beads and a magnetic device; the magnetic beads are placed in the chamber of the reaction chamber 112; Figure 13 As shown, the magnetic device includes a magnetic block 401 and a motor 402. The magnetic block 401 is arranged on the outside of the bottom cavity wall of the reaction chamber 112. The magnetic block 401 is magnetically connected to the magnetic beads, and the motor 402 is driven and connected to the magnetic block 401. Specifically, the motor 402 is electrically connected to the controller 800, and the magnetic beads are placed in the first reagent of the reaction chamber 112. When the sample to be tested and the second reagent flow into the reaction chamber 112, the sample to be tested, the second reagent, and the first reagent are mixed to produce a chemical reaction, then the controller 800 energizes the motor 402 and drives the magnetic block 401 to move. Based on the magnetic connection between the magnetic block 401 and the magnetic beads, the magnetic block 401 drives the magnetic beads to rotate and stir, so that the sample to be tested and the detection reagent are evenly mixed, ensuring that the chemical reaction is fully carried out, which is conducive to improving the reliability and accuracy of the self-detection.

[0116] According to some embodiments of the present application, the temperature control module 600 includes: a thermally conductive insulation layer, a heating device and a temperature sensor, the thermally conductive insulation layer covers the outer wall of the test channel 210 and wraps the test channel 210; the heating device is arranged in the thermally conductive insulation layer, and the heating device and the temperature sensor are both electrically connected to the controller 800; the temperature sensor is used to detect the ambient temperature inside the test instrument.

[0117] Specifically, the thermally conductive insulation layer is an aluminum alloy sleeve, which plays the role of heat preservation and uniform heat conduction. It is understandable that other metal materials can also be used to make the thermally conductive insulation layer. This application does not impose specific restrictions on the material of the thermally conductive insulation layer. The thermally conductive insulation layer covers the outer wall of the test channel 210, and the thermally conductive insulation layer does not cover the identification code window 212, the first accommodating groove 213, and the second accommodating groove 214 opened on the test channel 210; to ensure that the identification code scanner can scan the identification code area 113, while ensuring that it does not affect the operation of the optical detection module 700.

[0118] Specifically, the heating device is a thermocouple, which plays a heating role. The number of heating devices can be set according to actual needs. Therefore, this application does not make a specific limit on the number of heating devices.

[0119] In the embodiment of the present application, the temperature control module 600 is provided to monitor the ambient temperature in the instrument where the sampler 100 is located in real time, and the ambient temperature in the instrument can be changed to provide suitable temperature conditions for the chemical reaction carried out in the sampler 100.

[0120] According to some embodiments of the present application, Figure 1 and Figure 28 As shown, the detection and analysis device 1000 also includes a display component 900, which is arranged on the surface of the housing 200 and is electrically connected to the controller 800. The display component 900 is used to display the test results of the sample to be tested obtained by analysis. After the detection and analysis device 1000 analyzes and obtains the test results, the display component 900 can intuitively display the test results of the sample to be tested in a visual form, such as digital readings, charts, trend analysis, etc. The present application provides a display component 900 so that users can quickly and conveniently obtain and understand this data.

[0121] Specifically, the display component 900 can be a liquid crystal display (LCD), an organic light emitting diode display (OLED) or other types of electronic display devices for clearly displaying text, numbers, charts or images. The display component 900 can display various types of detection data, including but not limited to concentration values, reaction times, spectrograms, trend analysis, etc. The display component 900 is usually combined with a user interface (UI) design to provide easy-to-operate menus, buttons and instructions so that users can easily navigate and select the required information. Therefore, this application does not place specific restrictions on the type of display component 900.

[0122] According to some embodiments of the present application, when the detection and analysis device 1000 does not include a display component (such as Figure 31 As shown), the detection and analysis device 1000 is connected to the terminal device for communication.

[0123] According to some embodiments of the present application, Figure 1 and Figure 2 As shown, the detection and analysis device 1000 also includes a power supply assembly A, which is electrically connected to the identification code scanner 300, the magnetic stirring device 400, the position sensor 500, the temperature control module 600, the optical detection module 700, the controller 800, and the display assembly 900. The power supply assembly A can provide stable power to ensure the normal operation of each component of the device.

[0124] Specifically, the power supply component A can be a built-in battery, an external power adapter, or other forms of power supply devices to ensure that the detection and analysis device 1000 can work normally in different environments. Therefore, this application does not make specific restrictions on the implementation of the power supply component A.

[0125] It will be understood that the controller 800 is used to execute the operating instructions of the detection and analysis device 1000. Specifically, the controller 800 includes a processor, memory, and control circuitry, and is responsible for receiving, processing, and executing user input operating instructions, as well as for the automatic operation of the device itself. The controller 800, programmed through software or firmware, implements operational control of various components of the device, controlling the coordinated operation of the identification code scanner 300, magnetic stirring device 400, position sensor 500, temperature control module 600, and optical detection module 700.

[0126] Specifically, the operation method of the sampler 100 and the detection and analysis equipment 1000 in the embodiment of the present application is as follows: the cuvette 110 is placed in the test channel 210 of the detection and analysis instrument, the temperature control module 600 preheats the ambient temperature in the instrument to the incubation temperature, and the capillary element 130 of the sampler 100 is used to absorb the sample to be tested; the capillary element 130 is connected to the push cylinder, the sealing film at the upper end of the liquid storage tube 120 of the sampler 100 is removed, and the capillary element 130 is inserted into the liquid storage tube 120; the push cylinder is operated to make the capillary element 130 pierce the liquid storage tube 120. The sealing membrane at the lower end of liquid storage tube 120 is penetrated, allowing the second reagent in liquid storage tube 120 to mix with the sample to be tested in capillary element 130 and flow into reaction chamber 112 to react with the first reagent. Light source generator 710 is activated to emit excitation light of a specific wavelength (i.e., the first light signal). This causes light signal receiver 720 to capture the second light signal reflected or transmitted from cuvette 110, convert it into an electrical detection signal, and transmit it to controller 800. Controller 800 automatically processes the electrical detection signal, converts it into a readable detection result, and displays it on display assembly 900. This simplifies sampling and detection operations, ensuring the accuracy and reliability of self-testing at home.

[0127] It is understandable that the detection and analysis equipment 1000 also includes mounting elements such as a mounting plate, a base, and screws to install and fix each module. Here, this application does not elaborate on the specific settings of the mounting elements.

[0128] Those skilled in the art will understand that the system structure shown in the figure does not constitute a limitation on the embodiments of the present application, and may include more or fewer components than shown in the figure, or a combination of certain components, or a different arrangement of components.

[0129] Those skilled in the art will understand that the system architecture and application scenarios described in the embodiments of the present application are intended to more clearly illustrate the technical solutions of the embodiments of the present application, and do not constitute a limitation on the technical solutions provided in the embodiments of the present application. Those skilled in the art will know that with the evolution of the system architecture and the emergence of new application scenarios, the technical solutions provided in the embodiments of the present application are also applicable to similar technical problems.

[0130] Based on the above system structure, various embodiments of the control method of the detection and analysis equipment of the present application are proposed below.

[0131] Second, as Figure 32 As shown, the control method of the detection and analysis device can be applied to Figure 1 The controller of the detection and analysis equipment shown in the figure, the detection and analysis equipment also includes: a shell, a sampler, an identification code scanner arranged in the shell, a magnetic stirring device, a position sensor, a temperature control module, and an optical detection module; the control method of the detection and analysis equipment may include but is not limited to steps S110 to S150.

[0132] Step S110: When the in-place signal from the position sensor is received, it is determined that the sampler is installed in the test channel and is located at the target test position, the identification code scanner is controlled to scan the identification code area, and the identification code information is obtained. The heating control information, detection reaction time, reagent information, and test control information are obtained from the identification code information.

[0133] Step S120: After the incubation is completed, the magnetic stirring device is controlled to start and the sample to be tested and the detection reagent in the sampler are stirred and shaken evenly.

[0134] Step S130: Control the temperature control module to perform a first heating process according to the heating control information, so that the ambient temperature in the instrument where the sampler is located reaches the target reaction temperature, so that the sample to be tested in the sampler and the detection reagent react chemically at the target reaction temperature to obtain a reactant.

[0135] Step S140: According to the test control information, the optical detection module is controlled to start, and the reactants in the sampler are optically detected through the light-transmitting area to obtain an electrical detection signal.

[0136] Step S150: Analyze the electrical detection signal according to the reagent information to obtain a detection result.

[0137] According to some embodiments of the present application, before step S110, that is, before receiving the in-position signal emitted by the position sensor, the control method of the detection and analysis device further includes: receiving a device startup instruction issued when the power switch of the detection and analysis device is triggered; in response to the device startup instruction, controlling the temperature control module to perform a second heating process to increase the ambient temperature in the instrument where the sampler is located to the target incubation temperature. When the outdoor temperature is low, the self-starting preheating is used to preliminarily increase the current ambient temperature in the instrument, laying the foundation for the subsequent rapid increase to the target test temperature. Specifically, the target incubation temperature is thirty-seven degrees Celsius.

[0138] Specifically, in step S110, the identification code information includes but is not limited to: heating control information, detection reaction time, reagent information, test control information, sample information and sampling information.

[0139] Specifically, the heating control information includes heating time and target reaction temperature, so that the heating time and target reaction temperature of the temperature control module can be directly controlled by the heating control information.

[0140] Specifically, reagent information includes but is not limited to: test item information, which is used to indicate the biochemical test items that need to be performed, such as specific analysis types or parameters; reagent names, to identify specific reagents, used to indicate the selection of corresponding operating procedures; batch information, to ensure the use of the same batch of reagents, to ensure experimental consistency, and to facilitate traceability; expiration date, used to verify whether the test reagents are within the validity period to avoid expired use; reference interval and linear range, used to set the result judgment standard and the effective range of detection; reaction curve, used to analyze the data after optical signal conversion and calculate the concentration.

[0141] Specifically, the test control information includes: test start time and test duration, which are used to determine the moment to start or shut down the optical detection module.

[0142] Specifically, the sample information includes: a sample number and a sample type, which are unique numbers used to identify each sample, as well as the sample type (such as blood, saliva, tissue, etc.).

[0143] Specifically, sampling information includes the sampling time and date. Accurate sampling dates and times facilitate tracking when samples are collected. Furthermore, if a dedicated operator is involved, sampling information may also include the sampling personnel's name or employee ID for accountability and record-keeping; a link or phone number so that personnel can scan an identification code and directly access the online system for sample tracking or contact relevant personnel.

[0144] When the detection and analysis equipment is used for detection through steps S110 to S150, the controller is used to: when receiving the in-place signal emitted by the position sensor, determine that the sampler is inserted in the test channel and is located at the target test position, first, control the identification code scanner to scan the identification code area, obtain the identification code information, and obtain the heating control information, detection reaction time, reagent information, and test control information from the identification code information; secondly, after the incubation is completed, control the magnetic stirring device to start, and stir and shake the sample to be tested and the detection reagent in the sampler; then, control the temperature control module to perform a first heating treatment according to the heating control information, so that the ambient temperature in the instrument where the sampler is located reaches the target reaction temperature, so that the sample to be tested in the sampler and the detection reagent undergo a chemical reaction at the target reaction temperature to obtain a reactant; finally, control the optical detection module to start according to the test control information, and optically detect the reactant in the sampler through the light-transmitting area to obtain an electrical detection signal; analyze the electrical detection signal according to the reagent information to obtain a detection result. Without the need for complex testing operations, the sampler containing the sample to be tested and the test reagent is inserted into the test channel, and the detection and analysis equipment can automatically detect the reactants obtained by the chemical reaction and obtain the test results, thereby improving the accuracy and reliability of the autonomous detection. Therefore, the embodiments of the present application can simplify the operation process of the self-detection and improve the accuracy and reliability of the autonomous detection.

[0145] According to some embodiments of the present application, the temperature control module includes: a heating device and a temperature sensor; step S130: controlling the temperature control module to perform a first heating treatment according to the heating control information so that the ambient temperature in the instrument where the sampler is located reaches the target reaction temperature, including but not limited to steps S131 to S132.

[0146] Step S131: Obtaining heating time and target reaction temperature from heating control information;

[0147] Step S132: Controlling the heating time of the heating device. When the temperature sensor detects that the ambient temperature in the instrument where the sampler is located is equal to the target reaction temperature, the heating device is controlled to stop working.

[0148] It is understandable that when detecting some markers in the sample to be tested, a higher temperature is required, so the operation of the heating device is controlled to reach the target reaction temperature to facilitate the normal progress of the chemical reaction.

[0149] Through step S131 to step S132, the operation of the heating device is automatically controlled based on the two preset parameters of heating time and target reaction temperature, thereby simplifying the operation process and ensuring that the reaction proceeds normally.

[0150] According to some embodiments of the present application, after step S132, that is, after controlling the heating device to stop working, the method further includes: obtaining the ambient temperature of the instrument in which the sampler is currently located through a temperature sensor; when the ambient temperature of the instrument in which the sampler is currently located is less than the target reaction temperature, controlling the heating device to heat so that the ambient temperature of the instrument in which the sampler is located is raised to the target reaction temperature. In this way, a dynamic insulation mechanism is implemented to ensure that the ambient temperature of the instrument in which the sampler is located is suitable for the chemical reaction to occur. It is understandable that in some special areas or some special climates, the temperature will drop faster, which is not conducive to detection. Therefore, the insulation mechanism of the embodiment of the present application ensures that the chemical reaction in the reaction chamber proceeds normally, thereby improving the reliability of self-detection.

[0151] According to some embodiments of the present application, the optical detection module includes: a light source generator and an optical signal receiver arranged opposite to each other;

[0152] According to the test control information, step S140 is further described. Step S140: according to the test control information, the optical detection module is controlled to start, and the reactants in the sampler are optically detected through the light-transmitting area to obtain an electrical detection signal, including but not limited to steps S141 to S144.

[0153] Step S141: Determine the test start time and test duration from the test control information;

[0154] Step S142: at the test start time, controlling the light source generator to emit a first light signal, causing the first light signal to be incident on the reaction chamber of the sampler, and causing the light signal receiver to receive a second light signal emitted after passing through the reaction chamber;

[0155] Step S143: controlling the optical signal receiver to convert the second optical signal into an electrical detection signal;

[0156] Step S144: After the test time has elapsed, the optical detection module is controlled to stop detection.

[0157] It is understood that the wavelength of the first optical signal can be set according to actual needs. The test start time and test duration can also be determined according to the actual test items and test types. This application does not impose specific restrictions on the wavelength of the first optical signal, the test start time, and the test duration.

[0158] The present application controls the test start time and test end time of the optical detection module through steps S141 to S144 to ensure detection accuracy, and collects electrical detection signals for subsequent analysis by the controller.

[0159] According to some embodiments of the present application, the sampler includes at least three cuvettes, each cuvette is provided with a connected accommodating chamber and a reaction chamber; the detection results include: marker concentration information, curve analysis information; step S150: analyzing the electrical detection signal according to the reagent information to obtain the detection result, including but not limited to steps S151 to S154.

[0160] Step S151: Obtaining a reagent standard curve of the detection reagent from the reagent information.

[0161] Step S152: Determine the absorbance of the sample to be tested based on the electrical detection signal, substitute the absorbance into the reagent standard curve, and calculate the marker concentration of the target analyte in the sample to be tested.

[0162] Step S153: When the sampler includes at least three cuvettes, the marker concentration of the target analyte in each cuvette is analyzed accordingly.

[0163] Step S154: performing a plotting process based on the absorbance of each sample to be tested and the marker concentration of each target analyte to obtain curve analysis information.

[0164] For example, when the sample to be tested is urine, the target analyte (also called a marker) is a kidney disease marker, such as creatinine, urine microalbumin, uric acid, etc. It is understood that different samples to be tested have different target analytes. This application does not impose any specific restrictions on the type of target analyte.

[0165] Specifically, further explaining step S154, the curve analysis information includes but is not limited to: a first analysis curve of each target analyte, which is used to indicate the change trend of the absorbance OD of the corresponding target analyte with the reaction time t, such as Figure 31 As shown; the second analysis curve is used to indicate the trend of concentration values of different markers changing with time t; the third analysis curve is used to indicate the trend of absorbance OD of different markers changing with concentration values, as shown Figure 34 As shown; the fourth analysis curve is used to indicate the relationship between the light signal intensity obtained by converting the absorbance OD and the time t. By obtaining multiple analysis curves through multi-dimensional analysis, the marker can be analyzed more comprehensively and the detection reliability can be improved. It is understandable that since the concentration of the target analyte in the sample to be tested affects the reaction rate, different samples to be tested may have N such curves, that is, Figure 33 C1, C2, C3, C4...Cn in it.

[0166] Through steps S151 to S154, automated analysis is completed to obtain detection results including marker concentration information and curve analysis information, thereby improving the efficiency of detection and analysis.

[0167] According to some embodiments of the present application, the detection and analysis device further includes: a display component; after analyzing the electrical detection signal based on the reagent information to obtain a detection result, the control method further includes: obtaining sample information and sampling information from the identification code information; associating and storing the sample information and sampling information with the corresponding detection result to obtain associated information; and displaying the associated information on the display component. By associating and displaying the sample information and sampling information with the corresponding detection result, the user can easily call and view the information, thereby improving the ease of use of the device.

[0168] According to some embodiments of the present application, when the detection and analysis device does not include a display component and is communicatively connected to a terminal device; after analyzing the electrical detection signal according to the reagent information to obtain the detection result, the control method further includes: obtaining sample information and sampling information from the identification code information; associating the sample information and sampling information with the corresponding detection result to obtain associated information; generating a new identification code according to the associated information, and sending the new identification code to the terminal device; or sending the associated information directly to the terminal device. After associating the sample information and sampling information with the corresponding detection result, the associated information is directly pushed to the APP in the terminal device for the user to view the detection result; or a new identification code is generated based on the associated information for the user to scan and obtain the detection result; thus, the convenience of use is improved.

[0169] For example, when the sampler has three cuvettes, the specific use process of the detection and analysis equipment is as follows: the detection and analysis equipment is used in conjunction with a special sampler with three cuvettes. After the detection and analysis equipment is turned on, it can automatically detect whether the temperature control module, magnetic stirring device and optical detection module are operating normally. After the detection is completed and confirmed to be operating normally, it will be turned on normally. The internal temperature sensor of the detection and analysis equipment can detect the ambient temperature inside the instrument, and after the power is turned on, the temperature control module automatically raises the internal temperature of the instrument to 37°C. After the cuvette filled with reagents is inserted into the test channel, the position sensor is used to determine whether the cuvette has reached the correct target test position. When the cuvette has reached the correct target test position, the identification code scanner is started to scan the identification code information on the cuvette. The QR code information contains information such as the reagent name, batch, expiration date, as well as the reference range, linear range, reaction curve, test temperature, test time and other information of the reagent. Once the above information is recognized, the identification code scanner transmits the information to the processing chip (also known as the controller) on the main control board. The controller automatically controls the heating time of the temperature control module and the target reaction temperature to be achieved based on the above information, controls the magnetic stirring device to mix the reagents after the incubation is completed, controls the optical detection module to start the test at the specified time, and controls the test to end according to the established method. After the test is completed, the optical detection module converts the light signal into an electrical signal and transmits it to the controller. The controller substitutes the test result into the reagent curve, calculates the final concentration in the sample, and displays the final result on the instrument display.

[0170] like Figure 35 As shown, the present invention also provides a controller, including: a processor 1101, which can be implemented by a general-purpose central processing unit, a microprocessor, an application-specific integrated circuit, or one or more integrated circuits, and is used to execute relevant programs to implement the technical solutions provided by the embodiments of the present application; a memory 1102, which can be implemented in the form of a read-only memory, a static storage device, a dynamic storage device, or a random access memory. The memory 1102 can store an operating system and other application programs. When the technical solutions provided in the embodiments of this specification are implemented through software or firmware, the relevant program codes are stored in the memory 1102, and the processor 1101 calls and executes the control method of the detection and analysis device of the embodiment of the present application; the input / output interface 1103 is used to realize information input and output; the communication interface 1104 is used to realize communication interaction between this device and other devices, and communication can be realized through wired means (such as USB, network cable, etc.) or wireless means (such as mobile network, WIFI, Bluetooth, etc.); the bus 1105 transmits information between the various components of the device (such as the processor 1101, memory 1102, input / output interface 1103 and communication interface 1104); wherein the processor 1101, memory 1102, input / output interface 1103 and communication interface 1104 realize communication connection with each other within the device through the bus 1105.

[0171] An embodiment of the present application further provides a storage medium, which is a computer-readable storage medium and stores a computer program. When the computer program is executed by a processor, the control method of the above-mentioned detection and analysis device is implemented.

[0172] The memory, as a non-transient computer-readable storage medium, can be used to store non-transient software programs and non-transient computer executable programs. In addition, the memory may include a high-speed random access memory, and may also include a non-transient memory, such as at least one disk storage device, a flash memory device, or other non-transient solid-state storage device. In some embodiments, the memory optionally includes a memory remotely located relative to the processor, and these remote memories can be connected to the processor via a network. Examples of the above-mentioned networks include but are not limited to the Internet, an intranet, a local area network, a mobile communication network and a combination thereof. The device embodiments described above are merely schematic, wherein the units described as separate components may or may not be physically separated, and are located in one place, or may be distributed to multiple network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the present embodiment.

[0173] The above is a specific description of the preferred implementation of the present application, but the present application is not limited to the above implementation mode. Technical personnel familiar with the field can also make various equivalent modifications or substitutions without violating the spirit of the present application. These equivalent modifications or substitutions are all included in the scope defined by the present application.

Claims

1. A detection and analysis device, characterized in that: include: A housing, a sampler, an identification code scanner, a magnetic stirring device, a position sensor, a temperature control module, an optical detection module, and a controller arranged in the housing; wherein, A test channel is provided in the housing; The sampler is inserted into the test channel, and an identification code area and a light-transmitting area are provided on the sampler; the sampler is used to hold the sample to be tested and the detection reagent; The scanning port of the identification code scanner faces the identification code area; The magnetic stirring device is arranged at the bottom of the sampler; The position sensor is arranged in the test channel; The temperature control module is arranged on the periphery of the test channel; The optical detection module is arranged at the bottom of the test channel and on both sides of the sampler; The controller is electrically connected to the identification code scanner, the magnetic stirring device, the position sensor, the temperature control module, and the optical detection module respectively.

2. The detection and analysis equipment according to claim 1, characterized in that: The sampler includes at least one cuvette (n≥1), and the cuvette is matched with the optical detection module; wherein, The number of cuvettes n=1 is arranged in any position, The number of cuvettes n=2 is arranged linearly, The number n≥3 of the cuvettes is arranged in a linear or two-dimensional geometric or grid pattern.

3. The detection and analysis equipment according to claim 2, characterized in that: Each cuvette is provided with a communicating accommodating chamber and a reaction chamber, and the side wall of the reaction chamber is light-transmissive; the reaction chamber is used to mix the sample to be tested and the detection reagent and to react biochemically, and to contain the reactants produced by the biochemical reaction.

4. The detection and analysis equipment according to claim 3, characterized in that: The identification code area is provided on the side wall of the accommodating cavity of at least one of the cuvettes.

5. The detection and analysis equipment according to claim 1, characterized in that: An identification code window is correspondingly opened on the side wall of the test channel, and the identification code window is used to display the identification code area.

6. The detection and analysis equipment according to any one of claims 2 to 4, characterized in that: The test channel includes sub-channels, the number of the sub-channels is the same as the number of the cuvettes, and one sub-channel is used to place one corresponding cuvette.

7. The detection and analysis equipment according to claim 1, characterized in that: The detection and analysis equipment further includes: an annular guide rail fixedly connected to the housing, the annular guide rail being arranged around the test channel, the identification code scanner being connected to the annular guide rail, and the identification code scanner being movable along the annular guide rail.

8. The detection and analysis equipment according to claim 6, characterized in that: Each of the optical detection modules includes: a light source generator and a light signal receiver that are arranged opposite to each other, wherein the light source generator is arranged on one side of the reaction chamber of the cuvette; and the light signal receiver is arranged on the other side of the reaction chamber of the cuvette.

9. The detection and analysis equipment according to any one of claim 8, characterized in that: There is at least one light source generator and at least one optical signal receiver.

10. The detection and analysis equipment according to claim 8, characterized in that: A first accommodating groove and a second accommodating groove are provided on the side wall edge of the bottom of the test channel; the first accommodating groove is used to accommodate the light source generator; and the second accommodating groove is used to accommodate the optical signal receiver.

11. The detection and analysis equipment according to claim 8, characterized in that: The magnetic stirring device includes: magnetic beads and a magnetic device; the magnetic beads are placed in the chamber of the reaction chamber; the magnetic device includes a magnetic block and a motor, the magnetic block is arranged on the outside of the bottom cavity wall of the reaction chamber, the magnetic block is magnetically connected to the magnetic beads, and the motor is drivingly connected to the magnetic block.

12. The detection and analysis equipment according to claim 1, characterized in that: The temperature control module includes: a thermally conductive insulation layer, a heating device and a temperature sensor. The thermally conductive insulation layer covers the outer wall of the test channel and wraps the test channel. The heating device is arranged in the thermally conductive insulation layer. The heating device and the temperature sensor are both electrically connected to the controller. The temperature sensor is used to detect the ambient temperature inside the test instrument.

13. The detection and analysis equipment according to claim 1, characterized in that: The detection and analysis device further includes: a display component, which is arranged on the surface of the housing and electrically connected to the controller.

14. The detection and analysis equipment according to claim 1, characterized in that: When the detection and analysis device does not include a display component, the detection and analysis device is communicatively connected with a terminal device.

15. A control method for a detection and analysis device, characterized in that: The controller of the detection and analysis device according to any one of claims 1 to 14 is applied thereto, wherein the detection and analysis device further comprises: a housing, a sampler, an identification code scanner disposed within the housing, a magnetic stirring device, a position sensor, a temperature control module, and an optical detection module; and the method comprises: When receiving the in-position signal emitted by the position sensor, it is determined that the sampler is inserted into the test channel and is located at the target test position, the identification code scanner is controlled to scan the identification code area to obtain the identification code information, and the heating control information, the detection reaction time, the reagent information, and the test control information are obtained from the identification code information; After the incubation is completed, the magnetic stirring device is controlled to start and the sample to be tested and the detection reagent in the sampler are stirred and shaken; controlling the temperature control module to perform a first heating process according to the heating control information, so that the ambient temperature in the instrument where the sampler is located reaches a target reaction temperature, so that the sample to be tested in the sampler and the detection reagent undergo a chemical reaction at the target reaction temperature to obtain a reactant; According to the test control information, the optical detection module is controlled to start, and the reactant in the sampler is optically detected through the light-transmitting area to obtain an electrical detection signal; The electrical detection signal is analyzed according to the reagent information to obtain a detection result.

16. The control method of the detection and analysis equipment according to claim 15, characterized in that: Before receiving the in-position signal sent by the position sensor, the method further includes: receiving a device startup instruction issued when a power switch of the detection and analysis device is triggered; In response to the device startup instruction, the temperature control module is controlled to perform a second heating process to adjust the ambient temperature in the instrument where the sampler is located to the target incubation temperature.

17. The control method of the detection and analysis equipment according to claim 15, characterized in that: The temperature control module includes: a heating device and a temperature sensor; The step of controlling the temperature control module to perform a first heating process according to the heating control information so that the ambient temperature in the instrument where the sampler is located reaches a target reaction temperature includes: Obtaining a heating duration and a target reaction temperature from the heating control information; The heating device is controlled to work for the heating time, and when the temperature sensor detects that the ambient temperature in the instrument where the sampler is located is equal to the target reaction temperature, the heating device is controlled to stop working.

18. The control method of the detection and analysis equipment according to claim 17, characterized in that: After controlling the heating device to stop working, the method further includes: Acquiring the ambient temperature of the instrument where the sampler is currently located through the temperature sensor; When the ambient temperature in the instrument where the sampler is currently located is lower than the target reaction temperature, the heating device is controlled to heat the instrument so as to increase the ambient temperature in the instrument where the sampler is located to the target reaction temperature.

19. The control method of the detection and analysis equipment according to claim 15, characterized in that: The optical detection module includes: a light source generator and an optical signal receiver arranged opposite to each other; The method of controlling the optical detection module to start according to the test control information and optically detecting the reactant in the sampler through the light-transmitting area to obtain an electrical detection signal includes: Determining a test start time and a test duration from the test control information; At the test start time, controlling the light source generator to emit a first light signal, causing the first light signal to be incident on the reaction chamber of the sampler, and causing the light signal receiver to receive a second light signal emitted after passing through the reaction chamber; controlling the optical signal receiver to convert the second optical signal into the electrical detection signal; After the test time has elapsed, the optical detection module is controlled to stop detection.

20. The control method of the detection and analysis equipment according to claim 19, characterized in that: The sampler includes at least two cuvettes, each of which is provided with a communicating accommodating chamber and a reaction chamber; The test results include: marker concentration information and curve analysis information; The step of analyzing the electrical detection signal according to the reagent information to obtain a detection result includes: Obtaining a reagent standard curve of the detection reagent from the reagent information; Determining the absorbance of the sample to be tested according to the electrical detection signal, substituting the absorbance into the reagent standard curve, and calculating the marker concentration of the target analyte in the sample to be tested; When the sampler includes at least two cuvettes, the marker concentration of the target analyte of the sample to be tested in each of the cuvettes is analyzed accordingly; The curve analysis information is obtained by plotting the absorbance of each sample to be tested and the marker concentration of each target analyte.

21. The control method of the detection and analysis equipment according to claim 19, characterized in that: The detection and analysis equipment further includes: a display component; After analyzing the electrical detection signal according to the reagent information to obtain a detection result, the method further includes: Obtaining sample information and sampling information from the identification code information; Associating and saving the sample information, the sampling information and the corresponding detection result to obtain associated information; The associated information is displayed on the display component.

22. The control method of the detection and analysis equipment according to claim 19, characterized in that: When the detection and analysis device is connected to the terminal device for communication; After analyzing the electrical detection signal according to the reagent information to obtain a detection result, the method further includes: Obtaining sample information and sampling information from the identification code information; Associating and saving the sample information, the sampling information and the corresponding detection result to obtain associated information; A new identification code is generated according to the association information, and the new identification code is sent to the terminal device; or the association information is directly sent to the terminal device.

23. A controller, characterized in that: It includes at least one processor and a memory for communicating with the at least one processor; the memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to execute the control method of the detection and analysis equipment as described in any one of claims 15 to 22.

24. A computer-readable storage medium, characterized in that The computer-readable storage medium stores computer-executable instructions, and the computer-executable instructions are used to enable a computer to execute the control method of the detection and analysis device according to any one of claims 15 to 22.

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