Consumable for aerosolizable formulations

Abstract

The present disclosure provides a consumable for an aerosolizable formulation comprising one or more sensory agents, a sweetening agent, and at least one compound as a humectant, where at least one sensory agent is a warming agent or a potting agent. A method of preparing an aerosol, an aerosolizable formulation containing the consumable and an aerosol supply system are also provided.

Description

Technical Field

[0001] The present disclosure relates to a consumable for an aerosolizable formulation, in particular an aerosolizable formulation suitable for use in an electronic aerosol delivery system such as an electronic cigarette. The present disclosure also relates to uses of the consumable, a container containing the formulation, and a method for generating an aerosol using the formulation. Background Art

[0002] Devices have been developed that allow users to replicate some of the smoking experience without using traditional cigarettes. Specifically, devices such as electronic cigarettes have been developed that allow users to generate an artificial aerosol that can then be inhaled to replicate the smoking experience. Aerosols are typically produced by vaporizing a liquid containing nicotine and an aerosol-forming component (such as glycerin). Vaporization occurs via a heater (or other aerosolizing device) powered by a power source such as a battery.

[0003] Other devices exist that attempt to replicate the smoking experience without using traditional cigarettes. These devices can be referred to as tobacco heating devices, as they generally have the ability to heat tobacco without burning it.

[0004] Electronic cigarettes and tobacco heating devices are collectively referred to as aerosol delivery devices or aerosol delivery systems. However, a potential disadvantage of such devices or systems, particularly electronic cigarettes, is that they may not fully replicate the sensory experience typically associated with smoking traditional cigarettes, which may be less than ideal for users of traditional cigarettes.

[0005] Therefore, it is desirable to provide an improved sensory experience delivered by an aerosol delivery device / aerosol supply system that more closely replicates the sensory experience of smoking. This can be achieved by improving one or more sensory properties of the aerosolizable formulation in the device so that it replicates the inhalation of a conventional cigarette. Summary of the Invention

[0006] The present disclosure relates to a combination of ingredients that can be used in aerosolizable formulations to improve at least one organoleptic property thereof. Specifically, a combination of one or more sensates, sweeteners, and humectants (e.g., triacetin) provides a consumable that can improve at least one organoleptic property of an aerosolizable formulation so that the formulation more closely replicates the puffing of a traditional cigarette when inhaled by a user. Thus, the improvement in organoleptic properties may be relative to a formulation that does not combine one or more sensates, sweeteners, and humectants (e.g., triacetin), wherein the organoleptic properties may be selected from taste, mouthfeel, and / or smoking experience. In one embodiment, the humectant defined in claim 1 is triacetin; however, the present disclosure is not limited to triacetin.

[0007] According to some embodiments described herein, there is provided a consumable for an aerosolizable formulation, wherein the consumable comprises (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent, (ii) a sweetener, and (iii) at least one compound that is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups. In some embodiments, compound (iii) has a boiling point of at least 200° C. at atmospheric pressure (760 mmHg; 101,325 Pa). In some embodiments, (ii) and (iii) are different.

[0008] According to some embodiments described herein, there is provided a consumable for an aerosolizable formulation, wherein the consumable comprises one or more sensates, a sweetener, and triacetin, wherein at least one sensate is a warming agent or a tingling agent, optionally wherein the weight ratio of the sensate to the sweetener is greater than about 1:1 to about 3:1.

[0009] According to some embodiments described herein, there is provided an aerosolizable formulation for use in an aerosol delivery system, comprising a consumable as defined herein, a carrier, and optionally nicotine.

[0010] According to some embodiments described herein, there is provided an aerosolizable formulation or an aerosol generating system comprising a consumable as defined herein, an aerosol former material, one or more binders and optionally a botanical material.

[0011] According to some embodiments described herein, there is provided an aerosolizable formulation for an aerosol supply system comprising a consumable product as defined herein, wherein the formulation comprises from about 0.0001 wt % to about 5 wt % of one or more sensates and from greater than about 1 wt % to less than about 35 wt % of a humectant (e.g., triacetin).

[0012] According to some embodiments described herein, there is provided an aerosolizable formulation for an aerosol supply system comprising a consumable product as defined herein, wherein the formulation comprises from about 0.001 wt % to about 1 wt % of one or more sensates and greater than about 5 wt % to less than about 20 wt % of a humectant (e.g., triacetin).

[0013] According to some embodiments described herein, there is provided an article comprising an aerosolizable formulation as defined herein.

[0014] According to some embodiments described herein, there is provided an aerosol supply system comprising an aerosol supply device and an article as defined herein.

[0015] According to some embodiments described herein, there is provided a method of forming an aerosol, the method comprising providing an aerosolizable formulation as defined herein and aerosolizing the formulation.

[0016] According to some embodiments described herein, there is provided a method of forming an aerosol, the method comprising providing an aerosol generating system or an aerosol supply system as defined herein, and aerosolising the formulation and / or consumable in the system.

[0017] According to some embodiments described herein, there is provided a sealed container comprising an article as defined herein, optionally wherein the container is hermetically sealed and formed from a material that inhibits or prevents the passage of ultraviolet light.

[0018] According to some embodiments described herein, there is provided the use of about 0.0001 wt % to about 5 wt % of one or more sensates in combination with a sweetener and a compound that is a humectant to alter at least one sensory characteristic of an aerosolizable formulation or an aerosol generating system, wherein at least one sensate is a warming or tingling agent, and wherein the compound has a boiling point of at least 200° C. at atmospheric pressure.

[0019] According to some embodiments described herein, about 0.0001 wt % to about 5 wt % of one or more sensates are provided with a sweetener and a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 Use of a compound combination of a hydrocarbon-based polyol to modify at least one sensory property of an aerosolizable formulation or an aerosol generating system, wherein at least one sensate is a warming or tingling agent, wherein the polyol comprises three or more hydroxyl groups.

[0020] According to some embodiments described herein, there is provided use of about 0.001 wt % to about 1 wt % of one or more sensates in combination with a sweetener and triacetin to improve at least one sensory characteristic of an aerosolizable formulation, wherein at least one sensate is a warming or tingling agent.

[0021] According to some embodiments, there is provided the use of a humectant to modify the mouthfeel of an aerosolizable formulation or an aerosol generating system, the humectant having a boiling point of at least 200°C at atmospheric pressure, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

[0022] According to some embodiments, there is provided a use of a humectant to modify the mouthfeel of an aerosolizable formulation or an aerosol generating system, wherein the humectant is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

[0023] According to some embodiments described herein, there is provided the use of about 0.0001 wt % to about 5 wt % of a warming or tingling agent in combination with a sweetener and a compound that is a humectant in a tobacco-flavored aerosolizable formulation or an aerosol-generating system to alter the tobacco flavor intensity of the formulation or consumable in the system, wherein the humectant compound has a boiling point of at least 200° C. at atmospheric pressure.

[0024] According to some embodiments described herein, there is provided the use of about 0.001 wt % to about 0.05 wt % of a warming or tingling agent in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation to modify its tobacco flavor intensity.

[0025] According to some embodiments described herein, there is provided a use of about 0.0001 wt % to about 5 wt % of one or more sensates in combination with a sweetener and a humectant in a tobacco flavor aerosolizable formulation to modify the tobacco flavor intensity thereof, wherein at least one sensate is a warming agent or a tingling agent, wherein the humectant has a boiling point of at least 200° C. at atmospheric pressure and / or is a C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups.

[0026] According to some embodiments described herein, there is provided the use of about 0.001 wt % to about 1 wt % of one or more sensates in combination with a sweetener and triacetin in a tobacco-flavored aerosolizable formulation to modify the tobacco flavor intensity thereof, wherein at least one sensate is a warming agent or a tingling agent.

[0027] These and other features, aspects, and advantages of the present disclosure will become apparent from the following detailed description and accompanying drawings. The present invention includes any combination of two, three, four, or more of the above-described embodiments, as well as any combination of two, three, four, or more features or elements set forth in this disclosure, regardless of whether these features or elements are explicitly combined in the detailed description of the embodiments herein. This disclosure is intended to be read as a whole so that any separable features or elements of the disclosed invention, unless the context clearly dictates otherwise, should be considered intended to be combinable in any of its various aspects and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Having described various aspects of the present disclosure in general terms above, reference will now be made to the accompanying drawings, which are not necessarily drawn to scale. The drawings are merely illustrative and should not be construed as limiting the present disclosure.

[0029] Figure 1 is a schematic diagram of an exemplary aerosol supply system.

[0030] Figure 2 This is a chart from Experiment 4, showing the product development test results.

[0031] Figure 3 This is a chart from Experiment 4, showing the product development test results.

[0032] Figure 4 This is a chart from Experiment 5, showing the product development test results.

[0033] Figure 5 This is a chart from Experiment 5, showing the product development test results. DETAILED DESCRIPTION

[0034] It should be understood that the present invention is not limited to the specific configurations, process steps, and materials disclosed herein, as these configurations, process steps, and materials may be varied. It should also be understood that the terminology used herein is for describing specific embodiments only and is not intended to be limiting, as the scope of the present invention will be limited only by the appended claims and their equivalents.

[0035] In this specification and claims, the singular forms "a," "an," and "the" include plural referents unless the context clearly dictates otherwise. References to "dry weight percent" or "dry weight basis" refer to the weight based on dry ingredients (i.e., all ingredients excluding water or carrier). References to "wet weight" refer to the weight of a formulation or composition, including water or carrier. Unless otherwise indicated, references to "weight percent" (or "wt %") of a formulation or composition reflect the total wet weight of the formulation or composition (i.e., including water / carrier).

[0036] Throughout this specification, unless otherwise indicated, the term "about" as used to modify the amount of an ingredient in a formulation of the invention or used in a method of the invention refers to variations in the numerical amount that may occur, for example, due to typical measurement and liquid handling procedures used to prepare concentrates or use solutions in the real world; due to inadvertent errors in these procedures; due to differences in the production, source, or purity of the ingredients used to prepare the formulation, or the method of implementation; etc. The term "about" also encompasses amounts that vary due to differences in equilibrium conditions of the formulation or composition resulting from a particular initial mixture. Whether or not modified by the term "about," the claims include equivalents of the amounts recited.

[0037] As described in the background above, aerosol delivery devices or systems typically allow users to replicate some aspects of the smoking experience without using traditional cigarettes. Specifically, aerosol delivery systems are designed to generate an artificial aerosol that users inhale to replicate the smoking experience. However, the aerosol produced by such systems does not fully replicate the sensory experience typically associated with smoking traditional cigarettes.

[0038] The "sensory gap" between using existing aerosolizable formulations and smoking traditional cigarettes includes one or more of taste, mouthfeel, and smoking experience. Unexpectedly, the compound combination of the present claims, namely one or more sensates (at least one of which is a warming / tingling agent), a humectant (e.g., triacetin) as defined in claim 1, and a sweetener, can modify (e.g., improve) at least one of these smoking sensations, thereby reducing this "sensory gap."

[0039] It will be understood by those skilled in the art that an "aerosolizable formulation" is a formulation that is capable of generating an aerosol when, for example, heated, irradiated, or energized in any other manner. For example, an "aerosolizable formulation," i.e., an aerosol-forming formulation, may be in the form of a solid, liquid, or semisolid (e.g., a gel), which may or may not contain an active substance and / or flavoring. In a preferred embodiment, the aerosolizable formulation is in the form of a liquid or a gel.

[0040] Cigarettes are used herein as exemplary combustible tobacco products; those skilled in the art will appreciate that the present disclosure is not limited to replicating one or more smoking sensations and may be equally applicable to replicating one or more sensations of smoking other combustible tobacco products, such as cigars, etc. These sensations may include taste, mouthfeel, smoking experience, or a combination thereof.

[0041] Taste is the sensation and / or perception of flavor, and in e-cigarettes, flavor is primarily delivered through aroma. When a user smokes an aerosol of a tobacco-flavored formulation (e.g., tobacco-flavored e-liquid or gel), they expect the aroma to be tobacco-like and to deliver a richness and complexity comparable to smoking.

[0042] Aerosol body and mouthfeel are the physical sensations that users experience in their oral cavity during and after smoking. Cigarette smoke is generally associated with "fullness" in the oral cavity and leaves a perceptible mouthcoating after use. The aftertaste of smoking can be described as lingering or indulgent. In the present disclosure, aerosolizable formulations and aerosol generating systems as defined herein can provide an aerosol body and mouthfeel comparable to those of smoking conventional cigarettes. Mouthfeel can include irritation and / or throat hit and mouthdrying, and mouthful of vapor (see properties in Experiments 1-5 below).

[0043] The smoking experience includes the desired nicotine sensorials of smoke and the sensory sensation of each puff gradually increasing to a perceived saturation level. Nicotine sensation includes nicotine "hit" (i.e., physiological reaction, sometimes referred to as "buzz") and impact (i.e., the user experiences stimulation and flavor), and is an indispensable part of the smoking experience. In the present disclosure, sweeteners have been shown to weaken / soften the nicotine sensation, while warming agents or tingling agents such as Symhea can provide a gradually increasing irritation, but this is rough and irritating. In contrast, the aerosolizable formulation of the present disclosure can provide a smoking experience that replicates cigarette smoke. The smoking experience can also include first-time puff satisfaction and visual steam, as described in Experiment 5 below.

[0044] Surprisingly, when used in an aerosol supply device, the consumables of the present disclosure improve the sensory experience of aerosolizable preparations. In addition, the level of the compound in the consumable can be adjusted to adjust the flavor intensity according to the consumer's preferences. This is beneficial because it maximizes the conversion and appeal of the aerosol supply system as a substitute for cigarettes or other combustible tobacco products. In addition to this range of smoking experiences, the consumables can also be combined with a range of flavors and substrates (such as e-liquids). For example, the consumables can be used with tobacco-flavored e-liquids, or with mint / menthol-flavored e-liquids or any plant preparation materials, for example, in the form of a gel.

[0045] For ease of reference, these and other aspects of the present invention are now discussed under appropriate section headings. However, the teachings under each section are not necessarily limited to each specific section. In other words, specific sections of this specification should not be read separately from other sections.

[0046] The ranges provided herein relate to preferred amounts of each component. Each of these ranges can be used alone or in combination with one or more other component ranges to provide preferred embodiments of the present invention.

[0047] Consumables for aerosolizable preparations

[0048] The present invention provides a consumable for an aerosolizable formulation, i.e., a consumable suitable for use in an aerosolizable formulation. The consumable may be as defined in claim 1; the consumable comprises (i) one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; (ii) a sweetener; and (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol includes three or more hydroxyl groups. Compound (iii) can have a boiling point of at least about 200° C. at atmospheric pressure, although the disclosure is not limited in this respect.

[0049] Without being bound by theory, it is believed that the moisturizing properties of compound (iii) are important for providing the replication of one or more smoking sensations. The term "humectant" is readily understood by those skilled in the art. It refers to a hygroscopic (water-absorbing) compound. Humectants are used in many products, including food, cosmetics, and pharmaceuticals. When used as a food additive, a humectant has the effect of retaining moisture in food. Therefore, a humectant can be described as attracting and retaining moisture in the air by absorption. In the context of the present disclosure, the moisturizing properties of compound (iii) can be beneficial in facilitating the observed changes in mouthfeel, thereby replicating one or more sensations experienced when smoking a combustible tobacco product (e.g., a cigarette). For example, a moisturizing compound (iii) can be a contributing factor to the perception of oral coating and / or oral "fullness" (i.e., aerosol alcohol thickness) after use, and each experience is changed to replicate the experience of smoking, for example, a traditional cigarette. Humectant compound (iii) can also be a contributing factor to the impact or throat hit of the product.

[0050] As described herein, a consumable for an aerosolizable formulation is also provided, wherein the consumable comprises: one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and triacetin, optionally wherein the weight ratio of the sensate to the sweetener is greater than about 1:1 to about 3:1. In some embodiments, a consumable for an aerosolizable formulation is provided, wherein the consumable comprises: one or more sensates, wherein at least one sensate is a warming agent or a tingling agent; a sweetener; and triacetin, wherein the weight ratio of the sensate to the sweetener is greater than about 1:1 to about 3:1. The aerosolizable formulation is configured to be suitable for use in an aerosol delivery system. This system is discussed further below.

[0051] Sensate

[0052] The consumables of the present disclosure comprise one or more sensates. At least one of the sensates is a warming agent or a tingling agent. The terms "sensate" or "sensate compound" (used interchangeably herein) refer to compounds that trigger a trigeminal nerve-mediated sensation in a user.

[0053] The use of sensory compounds is well documented in the food and pharmaceutical industries, and the sensations triggered include cooling, warming, and tingling. When used in aerosolizable formulations, these sensations should be experienced in the user's mouth, nose, and / or skin. The present disclosure is not limited in this regard, but it is preferred that these sensations be experienced in the mouth and / or nose. The terms "cooling," "warming," and "tingling" are well understood in the art.

[0054] Cooling agents, warming agents and tingling agents are typical small organic molecules that give users a cooling, warming or tingling sensation when they come into contact with the mouth, nose and / or skin. This sensation falls into the category of chemical senses and is produced because small organic molecules activate certain receptors in the skin and / or mucous membranes. Therefore, the experience of cooling, warming and / or tingling depends on the user's chemical sense. Chemical sense is also referred to in the art as "common chemical sense" or trigeminal chemical sense because it generally refers to sensations mediated by the trigeminal nerve, which are elements of the somatosensory system, distinguishing it from smell (the sense of smell and taste) and taste.

[0055] At least one sensate in the consumable of the present invention is a warming agent or a tingling agent. The warming agent or tingling agent can be selected from the group consisting of vanillin, sanshool, piperine, allyl isothiocyanate, cinnamyl phenylpropyl compound, ethyl ester, and combinations thereof, or the warming agent or tingling agent is an extract of at least one of horseradish oil, ginger oil, black pepper, long pepper, Szechuan pepper, cayenne pepper, Uzazi, or mustard oil.

[0056] Vanilloids are compounds with a vanillyl group, and many vanilloids bind to the transient receptor potential vanilloid type 1, or TRPV1, receptor, an ion channel that naturally responds to stimuli. TRPV1 is therefore a component of the mammalian somatosensory system. Vanilloids include capsaicin (8-methyl-N-vanillyl-6-nonamide) and nonivamide, as well as 3-phenylpropyl homovanillate, the main component of SymHeat PV used in the examples herein. Other vanilloids include gingerols, zingerone, and shogaols, as well as vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, and vanillyl butyl ether acetate. The chemical structures of capsaicin, 3-phenylpropyl homovanillate, gingerol, [6]-shogaol, and zingerone are shown in Appendix 1, along with vanillyl butyl ether.

[0057] Sanshool, exemplified by hydroxy-α-sanshool, is a compound responsible for the numbness and tingling sensations produced by foods prepared with szechuan peppercorns and uzashi. The term "sanshool" comes from the Japanese term for Japanese pepper, with the suffix "ol" meaning "alcohol." It is an agonist of TRPV1 and TRPA1 (an ion channel known to act as a sensor for pain, cold, and itch in humans and other mammals). Its chemical structure is shown in Appendix 1.

[0058] Cinnamylphenylpropyl compounds share the common structural characteristics of aromatically substituted primary alcohols / aldehydes / esters. They include 3-phenylpropylcinnamate and 3-phenyl-1-propanol, each of which has a spicy flavor and balsamic odor, as well as 3-phenylpropylisobutyrate, which has a fruity flavor and odor. In some embodiments, the cinnamylphenylpropyl compound is selected from 3-phenylpropylcinnamate, 3-phenyl-1-propanol, and combinations thereof.

[0059] In some embodiments, the warming agent or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or the warming agent or tingling agent is an extract of at least one of horseradish oil, mustard oil, ginger oil, black pepper, long pepper, numbing pepper, chili powder, or Uzazi.

[0060] In some embodiments, the warming or tingling agent is selected from the group consisting of vanilloids, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or the warming or tingling agent is an extract of at least one of ginger oil, black pepper, long pepper, or chili pepper.

[0061] In some embodiments, the warming agent or tingling agent comprises a vanillin, for example, the warming agent and tingling agent can comprise a combination of vanillin and a cinnamylphenylpropyl compound. In some embodiments, the warming agent or tingling agent is a vanillin, preferably 3-phenylpropyl homovanillate.

[0062] In some embodiments, the warming agent or tingling agent is selected from the group consisting of vanillyl ethyl ether, vanillyl propyl ether, 3-phenylpropyl homovanillate, capsaicinoid, gingerols (e.g., [6], [8],

[10] and / or

[12] -gingerol), vanillyl butyl ether, vanillyl butyl ether acetate, sanshool, piperine, zingerone, shogaols (e.g., (6)-shogaol), allyl isothiocyanate, and combinations thereof, or the warming agent or tingling agent is an extract of at least one of horseradish oil, ginger oil, black pepper, long pepper, prickly ash, chili powder, Uzazi, or mustard oil.

[0063] In some embodiments, the warming or tingling agent is selected from the group consisting of vanillyl ethyl ether, vanillyl propyl ether, vanillyl butyl ether, vanillyl butyl ether acetate, 3-phenylpropyl homovanillate, and combinations thereof.

[0064] In some embodiments, the warming agent or tingling agent is selected from the group consisting of vanilloids, gingerols (e.g., [6], [8],

[10] and / or

[12] -gingerol), zingerone, shogaols (e.g., (6)-shogaol), and combinations thereof, or the warming agent and tingling agent is ginger oil extract.

[0065] Where appropriate, all embodiments include all enantiomers and tautomers of the compounds. One skilled in the art will recognize compounds having optical properties (one or more chiral carbon atoms) or tautomeric characteristics. The corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art.

[0066] Some compounds may also exist as stereoisomers and / or geometric isomers, e.g., they may have one or more asymmetric centers and / or geometric centers and may therefore exist as two or more stereoisomers and / or geometric isomers. Where appropriate, all embodiments include the use of all stereoisomers and geometric isomers of these compounds and mixtures thereof. The terms used in the claims encompass these forms. For example, piperine has four geometric isomers, including chavicine, isopiperine, and isopiperine. The term "piperine" is used herein to refer to all geometric isomers and mixtures thereof.

[0067] In some embodiments, the one or more sensate agents consist of a warming agent and a tingling agent.

[0068] In some embodiments, the one or more sensate agents consists of a warming agent.

[0069] In some embodiments, the one or more sensate agents consists of a tingling agent.

[0070] The one or more defined sensates may be present in the consumable in an amount of from about 0.001 wt % to about 10 wt % based on the total weight of the consumable. Those skilled in the art will appreciate that this concentration range applies to the total amount of sensates, e.g., the total amount of the warming or tingling agent and the optional cooling agent. The addition of cooling agents is discussed further below.

[0071] A concentration range of about 0.001 wt% to about 10 wt% also applies to the definition of one or more sensates. For example, a consumable may include about 0.001 wt% to about 10 wt% of one or more sensates, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or an extract of at least one of ginger oil, black pepper, long pepper, numbing pepper, chili powder, or Uzazi. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate.

[0072] In some embodiments, based on the total weight of the consumable, one or more sensory agents defined herein are present in the consumable in an amount of about 0.001 wt% to about 5 wt%, such as about 0.001 wt% to about 2.5 wt%, preferably about 0.001 wt% to about 1 wt%, more preferably about 0.001 wt% to about 0.5 wt%. In some particularly preferred embodiments, one or more sensory agents as defined herein are present in the consumable in an amount of about 0.001 wt% to about 0.25 wt%.

[0073] In some embodiments, the warming or tingling agent is present in a concentration of about 0.0001 wt % to about 5 wt % based on the total weight of the consumable, such as about 0.0001 wt % to about 3 wt %, preferably about 0.0001 wt % to about 2.5 wt % based on the total weight of the consumable.

[0074] In some embodiments, the warming or tingling agent is present at a concentration of about 0.0001 wt% to about 5 wt% based on the total weight of the aerosolizable formulation, such as about 0.0001 wt% to about 3 wt%, preferably about 0.0001 wt% to about 2.5 wt%, and more preferably about 0.0001 wt% to about 1 wt%, based on the total weight of the aerosolizable formulation. In some embodiments, the warming or tingling agent is present at a concentration of about 0.0001 wt% to about 0.05 wt%, based on the total weight of the aerosolizable formulation. These concentration ranges can be combined with any of the above concentrations for the total amount of sensate.

[0075] Preferably, the warming agent or tingling agent is present in a concentration of about 0.0001 wt % to about 0.025 wt % based on the total weight of the aerosolizable formulation. More preferably, the warming agent or tingling agent is present in a concentration of about 0.0001 wt % to about 0.025 wt % based on the total weight of the aerosolizable formulation and is selected from the group consisting of vanillin, sanshool, piperine, cinnamyl phenylpropyl compound, ethyl ester, and combinations thereof, or the warming agent or tingling agent is an extract of at least one of ginger oil, black pepper, long pepper, prickly ash, chili powder, or Uzazi, for example, vanillin.

[0076] Alternatively, the warming agent or tingling agent may be present in a concentration of about 0.0001 wt % to about 5 wt % based on the total weight of the aerosolizable formulation and may be selected from the group consisting of vanillin, sanshool, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or the warming agent and tingling agent may be an extract of at least one of ginger oil, black pepper, long pepper, prickly ash, chili powder, or Uzazi, for example, vanillin.

[0077] In some embodiments, the one or more sensates consist of a warming agent or a tingling agent, such that the "total" concentration of the one or more sensates is from about 0.0001 wt % to about 5 wt %, such as from about 0.0001 wt % to about 3 wt %, preferably from about 0.0001 wt % to about 2.5 wt %, and more preferably from about 0.0001 wt % to about 1 wt %, based on the total weight of the consumable or formulation.

[0078] In some embodiments, the one or more sensate agents consist of a warming agent or a tingling agent such that the "total" concentration of the one or more sensate agents is from about 0.0001 wt% to about 1 wt%, preferably from 0.0001 wt% to about 0.5 wt%, and more preferably from about 0.0001 wt% to about 0.25 wt%, based on the total weight of the aerosolizable formulation.

[0079] In some embodiments, the one or more sensates further comprise a cooling agent. The term "cooling agent" is as defined above. It may be menthol or a cooling agent of a compound of formula (I) or a salt and / or solvate thereof.

[0080]

[0081] wherein X is hydrogen or OR', wherein R' is alkyl or alkenyl, which may be taken together with R1 to form a three to five membered heterocyclic radical, wherein the heterocyclic radical is optionally substituted with one or more substituents selected from OH, O-alkyl, alkyl-OH, alkyl-O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2 and CN; and wherein R1 and R2 are each independently selected from hydrogen, OH, OR a 、C(O)NR b R c and C(O)OR b R c ; When a double bond is present, R2 does not exist;

[0082] where R a Alkyl, alkenyl, C(O)R f or C(O)-alkyl-C(O)R f wherein the alkyl and alkenyl groups are optionally substituted with one or more substituents selected from OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, and CN; and wherein R f is alkyl, alkenyl, OH, O-alkyl, NH2, NH-alkyl, or N-(alkyl)2, wherein the alkyl and alkenyl groups are optionally substituted with one or more substituents selected from OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, and CN;

[0083] where R b and R care each independently hydrogen, alkyl, alkenyl, aryl, aralkyl, heteroaryl or heteroaralkyl, wherein the alkyl, alkenyl, aryl and heteroaryl groups are optionally substituted with one or more groups selected from OH, O-alkyl, NH2, NH-alkyl, N-(alkyl)2, NO2, CN and C(O)R f substituted by a substituent.

[0084] In some embodiments, X is hydrogen.

[0085] In some embodiments, X is OR', wherein R' is alkyl or alkenyl, which together with R1 forms a three- to five-membered heterocyclyl, wherein the heterocyclyl is optionally substituted with OH, O-alkyl, or alkyl-OH. In some embodiments, X is OR', wherein R' is alkyl, which together with R1 forms a four- or five-membered heterocyclyl, wherein the heterocyclyl is optionally substituted with alkyl-OH. In some embodiments, X is OR', wherein R' is alkyl, which together with R1 forms a four- or five-membered heterocyclyl, wherein the heterocyclyl is optionally substituted with alkyl-OH, and wherein R1 is OR a , where R a is alkyl, and wherein R2 is absent or is hydrogen.

[0086] In some embodiments, R1 is selected from OH, OR a and C(O)NR b R c , and R2 is absent or selected from OH and OR a In some embodiments, R1 is OH. In some embodiments, R1 is OH, and R2 is selected from OH and OR a .

[0087] In some embodiments, X is hydrogen and R1 is selected from OH, OR a and C(O)NR b R c R2 is either absent or selected from OH and OR a In some embodiments, X is hydrogen, R1 is selected from OR a and C(O)NR b R c , and R2 is absent or selected from OH and OR a .

[0088] In some embodiments, R1 is OR a , and R a is an alkyl group substituted with one or more OH substituents. R2 may be hydrogen.

[0089] In some embodiments, R1 is OR a , and R a It is C(O)R fgroup, or C(O)-alkyl-C(O)R f Group, where R f is alkyl optionally substituted with one or more OH substituents, or R f is OH. R2 may be hydrogen.

[0090] In some embodiments, R1 is C(O)NR b R c , where R b and R c Each is independently hydrogen, alkyl, aryl, aralkyl, heteroaryl or heteroaralkyl. In some embodiments, R1 is C(O)NR b R c , and R b and R c At least one of R2 may be hydrogen.

[0091] In some embodiments, R1 is C(O)NR b R c , where R b is hydrogen, and R c is selected from the group consisting of alkyl, aryl, aralkyl and heteroaralkyl. R2 may be hydrogen.

[0092] As used herein, the term "alkyl" includes saturated straight and branched chain alkyl groups, which may be (single or multiple) substituted or unsubstituted. In some embodiments, the alkyl group is C 1-10 In some embodiments, the alkyl group is C 1-8 In some embodiments, the alkyl group is C 1-6 In some embodiments, the alkyl group is C 1-3 In some embodiments, the alkyl group includes, for example, methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl, pentyl, and hexyl. In some embodiments, the alkyl group includes methyl, ethyl, propyl, or isopropyl.

[0093] As used herein, the term "alkenyl" includes unsaturated straight and branched chain alkenyl groups, which may be (single or multiple) substituted or unsubstituted. In some embodiments, the alkenyl group is C 2-10 In some embodiments, the alkenyl group is C 2-8 In some embodiments, the alkenyl group is C 2-6 In some embodiments, the alkenyl group is C 2-3 Alkenyl.

[0094] As used herein, the term "aryl" refers to a C 6-12Aromatic groups. Typical examples include phenyl and naphthyl. In some embodiments, the aryl group is phenyl.

[0095] The term "aralkyl" is used as a combination of the terms alkyl and aryl given above. For example, an aryl group can be formed by a diradical alkylene bridge (-CH2-) n bonded to a compound of formula (I), wherein n is 1-10, and wherein "aryl" is as defined above. Alternatively, the alkyl group may be bonded to the compound of formula (I) via a diradical aryl bridge, such as a phenyl group, wherein "alkyl" is as defined above. In some embodiments, the term "aralkyl" refers to a phenyl-alkyl group in which the phenyl group is bonded to a compound of formula (I).

[0096] As used herein, the term "heteroaryl" refers to a monovalent aromatic group of 1-12 carbon atoms with one or more oxygen, nitrogen and sulfur heteroatoms in the ring. In some embodiments, there are 1-4 oxygen, nitrogen and / or sulfur heteroatoms in the ring. In some embodiments, there are 1-3 oxygen, nitrogen and / or sulfur heteroatoms in the ring. In some embodiments, there are 2 oxygen and / or nitrogen heteroatoms in the ring. In some embodiments, there is 1 oxygen or nitrogen heteroatom in the ring. The nitrogen and sulfur heteroatoms can be optionally oxidized. Such heteroaryl groups can have monocycles (e.g., pyridyl or furyl) or multiple fused rings, provided that the point of attachment is through heteroaromatic ring atoms.

[0097] In some embodiments, heteroaryl is selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl, pyrrolyl, indolyl, quinolyl, isoquinolyl, quinazolinyl, quinoxalinyl, furyl, thienyl, furyl, pyrrolyl, imidazolyl, oxazolyl, isoxazolyl, isothiazolyl, pyrazolyl, benzofuranyl and benzothienyl. The heteroaryl ring can be unsubstituted or substituted. In some embodiments, heteroaryl is selected from the group consisting of pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl and pyrrolyl. In some embodiments, heteroaryl is pyridyl.

[0098] As used herein, the term "heterocyclyl" refers to a fully saturated or unsaturated monocyclic group having one or more oxygen, sulfur, or nitrogen heteroatoms in the ring. In some embodiments, the heterocyclyl has 1-3 heteroatoms in the ring. In some embodiments, the heterocyclyl has 1-3 oxygen and / or nitrogen heteroatoms in the ring. In some embodiments, the heterocyclyl has 1-3 oxygen heteroatoms in the ring. The nitrogen and sulfur heteroatoms may be optionally oxidized and the nitrogen heteroatom may be optionally quaternized. The heterocyclic group may be unsubstituted or substituted.

[0099] Exemplary monocyclic heterocyclic groups include, but are not limited to, pyrrolidinyl, pyrrolyl, pyrazolyl, oxiranyl, oxetanyl, pyrazolinyl, imidazolyl, imidazolinyl, oxazolyl, oxazolidinyl, isoxazolinyl, isoxazolyl, thiazolyl, thiadiazolyl, thiazolidinyl, isothiazolyl, isothiazolidinyl, furanyl, tetrahydrofuranyl, thienyl, oxadiazolyl, piperidinyl, piperazinyl, 2-oxopiperazinyl, 2-oxopyrrolidinyl, 2-oxoazepanyl, azepanyl, 4-piperidonyl, pyridinyl, pyrazinyl, pyrimidinyl, pyridazinyl, tetrahydropyranyl, morpholinyl, thiomorpholinyl, thiomorpholine sulfoxide, thiomorpholine sulfone, 1,3-dioxolane and tetrahydro-1,1-dioxothiphenyl, triazolyl and triazinyl.

[0100] In some embodiments, the heterocyclyl group is selected from the group consisting of oxiranyl, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, and 1,3-dioxolane. In some embodiments, the heterocyclyl group is 1,3-dioxolane.

[0101] Where appropriate, all embodiments include all enantiomers, tautomers and geometric isomers of compounds of formula (I). One skilled in the art will recognize compounds having optical properties (one or more chiral carbon atoms) or tautomeric characteristics. The corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art. Some compounds of formula (I) can also exist as stereoisomers and / or geometric isomers—for example, they can have one or more asymmetric centers and / or geometric centers and can therefore exist in two or more stereoisomeric and / or geometric isomeric forms. Where appropriate, all embodiments include the use of all individual stereoisomers and geometric isomers of these compounds and mixtures thereof. The terms used in the claims encompass these forms.

[0102] Suitable salts of formula (I) compound include suitable acid addition salts or basic salts thereof. Such salts and solvates thereof are known in the art. Suitable acid addition salts include carboxylates (e.g., formate, acetate, trifluoroacetate, propionate, isobutyrate, enanthate, decanoate, octanoate, stearate, acrylate, caproate, acrylate, ascorbate, citrate, glucuronate, glutamate, glycolate, α-hydroxybutyrate, lactate, tartrate, phenylacetate, mandelate, phenylpropionate, benzoate, chlorobenzoate, methylbenzoate, hydroxybenzoate, methoxybenzoate, dinitrobenzoate, o-acetoxybenzoate, salicylate, nicotinate, isonicotinate, cinnamate, oxalate, malonate,

[0014] The present invention also includes but is not limited to succinate, suberate, sebacate, fumarate, malate, maleate, hydroxymaleate, hippurate, phthalate or terephthalate), a hydrohalide (such as hydrochloride, hydrobromide or hydroiodide), a sulfonate (for example, benzenesulfonate, methyl-, bromo- or chloro-benzenesulfonate, xylenesulfonate, methanesulfonate, ethanesulfonate, propanesulfonate, hydroxyethanesulfonate, 1- or 2-naphthalenesulfonate or 1,5-naphthalenedisulfonate) or a sulfate, pyrosulfate, bisulfate, sulfite, bisulfite, phosphate, hydrogenphosphate, dihydrogenphosphate, metaphosphate, pyrophosphate or nitrate.

[0103] In some embodiments, the one or more sensate agents further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthanecarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0104] In some embodiments, the cooling agent is selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthanecarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, 3-menthoxypropane-1,2-diol and menthyl succinate.

[0105] In some embodiments, the cooling agent is selected from the group consisting of:

[0106]

[0107] The above chemical formula as well as the trade name and chemical name are also shown in Appendix 1.

[0108] In some embodiments, the cooling agent is WS-23, ie, N,2-3-trimethyl-2-propan-2-ylbutanamide.

[0109] In some embodiments, the cooling agent is selected from the group consisting of: (1S, 2R, 5S) -N-ethyl-5-methyl-2-(propan-2-yl) cyclohexanecarboxamide, ethyl 2-[[(1R, 2S, 5R) -5-methyl-2-propan-2-ylcyclohexanecarbonyl] amino] ethyl acetate, (1R, 2S, 5R) -N- (4-methoxyphenyl) -p-menthanecarboxamide, (1R, 2S, 5R) -N- (2- (pyridin-2-yl) ethyl) menthylcarboxamide, (-) -menthone-1,2-glycerol ketal, (-) -menthyl lactate, (-) -isopulegol, 3-((-) -menthyloxy) propane-1,2-diol and (-) -menthyl succinate. These compounds are shown in Appendix 1.

[0110] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)--N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(4-methoxyphenyl)-p-menthanecarboxamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone-1,2-glycerol ketal, (-)-menthyl lactate, 3-((-)-menthoxy)propane-1,2-diol and (-)-menthyl succinate.

[0111] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)--N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(4-methoxyphenyl)-p-menthanecarboxamide, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone-1,2-glycerol ketal, (-)-menthyl lactate, (-)-isopulegol and 3-((-)-menthoxy)propane-1,2-diol.

[0112] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone-1,2-glycerol ketal, (-)-menthyl lactate, (-)-isopulegol and 3-((-)-menthoxy)propane-1,2-diol.

[0113] In some embodiments, the cooling agent is selected from the group consisting of: (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-[[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, (-)-menthone-1,2-glycerol ketal, (-)-menthyl lactate, and 3-((-)-menthoxy)propane-1,2-diol.

[0114] In some embodiments, the cooling agent is (1R,2S,5R)-N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide. In another embodiment, the cooling agent is (1S,2R,5S)-N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide.

[0115] As described above, all embodiments include all enantiomers and tautomers of the compounds, where appropriate. All embodiments include the use of all individual stereoisomers and geometric isomers of these compounds, and mixtures thereof, where appropriate. The terms used in the claims encompass these forms.

[0116] In some embodiments, the one or more sensates consist of a cooling agent and a warming agent. In some embodiments, the one or more sensates consist of a cooling agent and a tingling agent. In some embodiments, the one or more sensates consist of a cooling agent, a warming agent, and a tingling agent.

[0117] As described above, the concentration range of about 0.001 to about 10 wt% relates to the total amount of sensates (e.g., warming or tingling agents) and optional cooling agents in the consumable. For example, the consumable may contain about 0.001 wt% to about 10 wt% of one or more sensates, wherein at least one sensate is a warming or tingling agent, the warming or tingling agent being selected from vanilloids, sanshool, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or an extract of at least one of ginger oil, black pepper, long pepper, numbing pepper, chili powder, or Uzazi, and wherein the one or more sensates optionally also include a cooling agent. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate. Preferably, the cooling agent is selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-mentholcarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)mentholcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol and menthyl succinate.

[0118] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001 wt% to about 5 wt%, wherein at least one sensate is a warming or tingling agent comprising a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0119] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001 wt% to about 2.5 wt%, wherein at least one sensate is a warming or tingling agent comprising a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0120] In some embodiments, one or more sensates are present in the consumable in an amount from about 0.001 wt% to about 1 wt%, wherein at least one sensate is a warming or tingling agent comprising a vanillin, and wherein the one or more sensates optionally further comprise a cooling agent selected from the group consisting of menthol, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl 2-(5-methyl-2-propan-2-ylcyclohexanecarbonylamino)acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-2,3-trimethyl-2-propan-2-ylbutanamide, N-(2-pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, isopulegol, 3-menthoxypropane-1,2-diol, and menthyl succinate.

[0121] As described above, the warming or tingling agent can be present in a concentration of about 0.0001 wt % to about 5 wt % based on the total weight of the aerosolizable formulation, and this range can be combined with the above concentrations to achieve a total amount of sensate including cooling agents. Preferably, the warming or tingling agent is present in a concentration of about 0.0001 wt % to about 3 wt %, more preferably about 0.0001 wt % to about 2.5 wt %, based on the total weight of the aerosolizable formulation.

[0122] In some embodiments, one or more sensates and their concentrations are selected based on their solubility in the moisturizing compound (iii). For example, the consumable can include an amount of one or more sensates in the moisturizing compound (iii), wherein the moisturizing compound (iii) is present in an amount of 50 wt % or more of the consumable, such as 60 wt % or more of the consumable, preferably 70 wt % or more. The moisturizing compound (iii) is defined as follows.

[0123] In some embodiments, the humectant compound (iii) includes triacetin and one or more sensory agents, and its concentration is selected based on its solubility in triacetin. For example, the consumable can include one or more sensory agents in a certain amount of triacetin, wherein the triacetin is present in an amount of 50wt% or more of the consumable, such as 60wt% or more of the consumable, preferably 70wt% or more. However, as described in the previous paragraph, these concentrations are not only related to triacetin as the humectant compound (iii), but also apply to other humectants defined in the appended claims and herein. In a particularly preferred embodiment, the humectant compound (iii) is present in an amount of 80wt% or more of the consumable.

[0124] Thus, the present invention provides a consumable product for an aerosolizable formulation, wherein the consumable product comprises:

[0125] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 5 wt % based on the total weight of the consumable;

[0126] (ii) sweeteners; and

[0127] (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, the at least one compound being present in an amount of 50 wt % or more of the consumable.

[0128] In some embodiments, the consumable comprises:

[0129] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 3 wt % based on the total weight of the consumable;

[0130] (ii) sweeteners; and

[0131] (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diols or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, the at least one compound being present in an amount of 60 wt % or more of the consumable.

[0132] In some embodiments, the consumable comprises:

[0133] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 2.5 wt % based on the total weight of the consumable;

[0134] (ii) sweeteners; and

[0135] (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diols or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, the at least one compound being present in an amount of 70 wt % or more of the consumable.

[0136] In some embodiments, the consumable comprises:

[0137] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 1 wt % based on the total weight of the consumable;

[0138] (ii) sweeteners; and

[0139] (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diols or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, the at least one compound being present in an amount of 80 wt % or more of the consumable.

[0140] In each of these embodiments, the warming or tingling agent, sweetener and / or humectant compound is as defined herein. For example, the at least one compound (iii) may be selected from C4-C 18 Glycerides, C4-C 18 Hydrocarbon citrate, C3-C 18 Hydrocarbon diols and C4-C 18 Hydrocarbyl triol; the sweetener may be a compound that combines T1R2 and / or T1R3, or a compound selected from oxadiazine sweeteners, aspartame sweeteners, sulfamate, calcium cyclamate, sugar alcohols, natural sweeteners, saccharin, sucralose, gluconic acid, and mixtures thereof; the warming agent or tingling agent may be selected from vanillin, sanshool, piperine, allyl isothiocyanate, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof.

[0141] sweeteners

[0142] The consumables of the present invention include sweeteners. The term "sweetener" refers to a substance used to make food or beverages taste sweeter, used to replace sugar (sucrose), i.e., a sugar substitute. Sweeteners are easily identified in the art and those skilled in the art should understand the term well. Sweeteners can be any sweetener or sweetener combination in natural or artificial form, or a combination of natural and artificial sweeteners. Examples of natural sweeteners include fructose, glucose, maltose, mannose, galactose, lactose, stevia, etc. Examples of artificial sweeteners include sucralose, isomaltulose, maltodextrin, saccharin, aspartame, acesulfame K, neotame, etc.

[0143] Sweeteners can be defined as compounds that bind to T1R2 and / or T1R3. Those skilled in the art will understand that the phrase "binds to T1R2 and / or T1R3" refers to compounds that bind to the T1R2 receptor and / or the T1R3 receptor. T1R2, also known as "taste receptor type 1 member 2," is a human protein encoded by the TAS1R2 gene. Similarly, T1R3, also known as "taste receptor type 1 member 3," is a human protein encoded by the TAS1R3 gene. Human sweet taste receptors are primarily formed by dimers of T1R2 and T1R3. However, natural sweeteners are understood to interact with the orthosteric binding pocket of T1R2 or T1R3.

[0144] The binding of sweet substances to sweet taste receptors activates trimeric G proteins and produces second messengers in taste cells. Both cyclic AMP and calcium can act as second messengers. Sweeteners and receptors involve several molecular interactions (e.g., van der Waals, electrostatic, hydrogen bonding, hydrophobic, etc.) as well as physicochemical complementarity between receptors and sweeteners. Protein structure files (receptors) can be retrieved from the Protein Data Bank and described using X-ray diffraction. Details are as follows:

[0145] T1R2 / T1R3:PDB:5X2P, https: / / www.rcsb.org / structure / 5X2P , DOI:10.2210 / pdb5X2P / pdb

[0146] The active site pocket of a protein molecule is the site where sweeteners bind to proteins. Those skilled in the art will understand how to determine whether a compound binds to the active site pocket of T1R2 and / or T1R3. For example, these experiments may involve the use of a HEK-based (human embryonic kidney 293 cell) calcium fluorescence imaging assay described and used in Winnig et al., BMC Structural Biology 2007, 7:66, which involves neohesperidin dihydrochalcone.

[0147] In some embodiments, the sweetener can be selected from any suitable compound that binds to T1R2 and / or T1R3.

[0148] In some embodiments, the sweetener is selected from oxadiazine sweetener, aspartame sweetener, sulfamate, cyclamates (such as sodium or calcium), sugar alcohol, natural sweetener, saccharin, sucralose, gluconic acid and mixtures thereof. Sugar alcohol can include erythritol, arabitol, ribitol, isomalt, maltitol, galactitol, iditol, mannitol, xylitol, lactitol, sorbitol or a combination thereof. It will be understood by those skilled in the art that when sugar alcohol is included in consumables, it can be used as a sweetener or a humectant. In some embodiments, (ii) and (iii) are different. For example, erythritol is C4-C 18 Hydrocarbon polyols, having a boiling point of at least 200°C at atmospheric pressure, have a moisturizing effect. 18 When the consumable contains a hydroxyalkyl polyol (e.g., a hydroxyalkyl polyol), in some embodiments, an additional sweetener may be added to the consumable.

[0149] In some embodiments, the sweetener is selected from acesulfame K, acesulfame K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof.

[0150] In some embodiments, the sweetener includes at least one selected from aspartame, stevioside, swingle extract, glycyrrhizin, perillartine, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, rubus extract, rebaudioside A, saccharin, sucralose and sodium cyclamate. In some embodiments, the sweetener includes at least one selected from aspartame, stevioside, saccharin, sucralose and sodium cyclamate. Preferably, the sweetener includes at least one selected from acesulfame-K, aspartame, neotame, saccharin, sucralose and sodium cyclamate. More preferably, the sweetener is neotame or aspartame, eg, neotame.

[0151] Those skilled in the art will appreciate that any of the above sweeteners can be used in combination to provide a "sweetener" in a defined consumable. In this regard, blending of sweeteners is well known in the art. For example, it can advantageously produce a synergistic sweetening effect, improve taste characteristics, or improve temporal characteristics. For example, aspartame is known to have synergistic effects with acesulfame K, saccharin, and cyclamates. Sucralose has moderate synergistic effects with other nutritive and non-nutritive sweeteners.

[0152] The absolute concentration of the sweetener is not critical to the present invention. In some embodiments, the sweetener and its concentration are selected based on its solubility in the humectant compound (iii). In some embodiments, the humectant compound (iii) includes triacetin and a sweetener, and its concentration is selected based on its solubility in triacetin.

[0153] In some embodiments, the concentration of the sweetener can be defined by the concentration of one or more sensates, specifically the weight ratio of the sensate to the sweetener. As described above, among the one or more sensates, at least one sensate is a warming agent or a tingling agent. Without wishing to be bound by theory, it is believed that the level of the sweetener can depend on the sensate level because the sweetener can balance any irritation or aftertaste caused by the warming agent / tingling agent. In some embodiments, the weight ratio of the sensate to the sweetener is greater than about 1:1 to about 3:1, such as greater than about 1:1 to about 2:1, preferably wherein the weight ratio of the sensate to the sweetener is about 2:1.

[0154] In some embodiments, the weight ratio of sensate to sweetener can be adjusted to take into account the potency of the sweetener. Sweet potency refers to how many times sweetener is sweeter than sucrose. Sucrose can be assigned a value of 1 (for a 10% sucrose solution; see, e.g., Godshall MA., Sugar J. 2007; 69: 12-20), while a sweetness potency greater than 1 is "more potent" than sucrose, and a sweetness potency less than 1 is "less potent" than sucrose.

[0155] Neotame is the sweetener used in the examples herein. As reported in Godshall MA in 2007, neotame is 7,000-13,000 times sweeter than sucrose (using a 10 wt% sucrose solution as a reference), and its average sweetness is 8,000 times that of sucrose. Therefore, when the weight ratios defined above are defined with neotame as the sweetener, they can be adjusted accordingly to obtain a more or less potent sweetener. For example, sucralose is 600 times sweeter than sucrose, which is 13.33 times lower than the average sweetness of 8,000 for neotame. Therefore, for sucralose, a weight ratio of a sensate to a neotame-based sweetener of greater than about 1:1 to about 3:1 becomes greater than about 1:13 to about 3:13. Similarly, a weight ratio of a sensate to a neotame-based sweetener of greater than about 1:1 to about 2:1 becomes greater than about 1:13 to about 2:13 for sucralose.

[0156] The adjustment of the weight ratio of sweetness potency "greater than about 1:1 to about 3:1" can be expressed by the following expression (1):

[0157] Sensate:Sweetener = greater than about 1:(8000 / z) to about 3:(8000 / z)

[0158] Where z = sweetness potency of the sweetener relative to a 10 wt% sucrose solution

[0159] Expression (1)

[0160] The adjustment of the weight ratio of sweetness potency "greater than about 1:1 to about 2:1" can be expressed by the following expression (2):

[0161] Sensate:Sweetener = greater than about 1:(8000 / z) to about 2:(8000 / z)

[0162] Where z = sweetness potency of the sweetener relative to a 10 wt% sucrose solution

[0163] Expression (2)

[0164] It will be understood by those skilled in the art that when the sweeteners are a combination, the average potency of the combination should be calculated based on the respective amounts of the sweeteners in the combination.

[0165] Sweeteners are defined as described above. Similarly, one or more sensates, including warming agents or tingling agents, are also defined as described above. For example, the weight ratio of sensate to sweetener is greater than about 1:1 to about 3:1, wherein the warming agent or tingling agent includes vanillin, and the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. This weight ratio can be adjusted according to the above expression (1).

[0166] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 3:1, wherein the warming agent or tingling agent is selected from the group consisting of vanillin, sanshool, piperine, cinnamyl phenylpropyl compound, ethyl ester and combinations thereof, or the warming agent or tingling agent is an extract of at least one of ginger oil, black pepper, long pepper, prickly ash, chili powder or Uzazi, for example, vanillin, and the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, calcium cyclamate, erythritol, xylitol, maltitol, mannitol, sorbitol, isomalt, tagatose, xylose, glycyrrhizin, stevia, saccharin, sucralose, gluconic acid and mixtures thereof. The weight ratio can be adjusted according to the above expression (1).

[0167] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin, and wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to the above expression (1).

[0168] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin, and the sweetener is selected from aspartame, neotame, stevia, saccharin, sucralose, or a mixture thereof. The weight ratio can be adjusted according to the above expression (1).

[0169] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises vanillin and the sweetener is selected from aspartame, neotame, or a mixture thereof. The weight ratio can be adjusted according to the above expression (1).

[0170] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 3:1, wherein the warming or tingling agent comprises a vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to the above expression (1).

[0171] In some embodiments, the weight ratio of the sensate to the sweetener is greater than 1:1 to about 2:1, wherein the warming or tingling agent comprises a vanillin (e.g., 3-phenylpropyl homovanillate) and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to the above expression (2).

[0172] In some preferred embodiments, the weight ratio of the sensate to the sweetener is about 2:1, wherein the warming or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener is selected from aspartame, neotame, or a mixture thereof (e.g., neotame). The weight ratio can be adjusted according to the above expression (2).

[0173] As mentioned above, the concentration of sweetener is not critical to the present disclosure. Preferably, the sweetener is balanced relative to the sensate according to the weight ratio defined above. However, the sweetener can exist in an amount of about 0.0001wt% to about 5wt%, such as about 0.0001wt% to about 1wt%, preferably about 0.0001wt% to about 0.5wt%, more preferably about 0.0001wt%-0.25wt%. In a particularly preferred embodiment, the sweetener can exist in an amount of about 0.0001wt%-0.1wt% based on the gross weight of the consumables.

[0174] In an aerosolizable formulation, the sweetener may be present in an amount of about 0.0001 wt % to about 5 wt %, such as about 0.0001 wt % to about 3 wt %, preferably about 0.0001 wt % to about 2.5 wt %, more preferably about 0.0001 wt % to about 1 wt %.

[0175] In the same manner as the weight ratios of sensates to sweeteners described above, those skilled in the art will appreciate that these sweetener concentrations can be defined based on neotame and adjusted based on the sweetness potency of the sweetener used in the consumable (if not neotame). As described above, sucralose has a sweetness that is approximately 13.3 times lower than that of neotame; therefore, for sucralose, a neotame concentration of about 0.0001 wt% to about 1 wt% would become about 0.0013 wt% to about 13.3 wt% based on the total weight of the aerosolizable formulation.

[0176] The following expressions can be defined:

[0177] About x wt% to about y wt% of neotame = about (8000 / z)x wt% to about (8000 / z)y wt% of alternative sweetener

[0178] Where z = sweetness potency of alternative sweetener relative to 10 wt% sucrose solution

[0179] Expression (3)

[0180] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 10 wt%, a sweetener in an amount of about 0.0001 wt% to about 5 wt%, and at least one compound (iii) (e.g., triacetin), based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent and tingling agent are present at a concentration of about 0.0001 wt% to about 5 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizer compound is defined according to the following embodiments. For example, the warming agent or tingling agent includes vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, cyclamates, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratios can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0181] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 5 wt%, a sweetener in an amount of about 0.0001 wt% to about 3 wt%, and at least one compound (iii), based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001 wt% to about 3 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizer compound is defined according to the following embodiments. For example, the warming agent or tingling agent includes vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0182] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 5 wt%, a sweetener in an amount of about 0.0001 wt%-2.5 wt%, and at least one compound (iii), based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001 wt% to about 2.5 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizing compound is defined according to the following embodiments. For example, the hot or tingling agent includes vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, cyclamates, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0183] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 2.5 wt%, a sweetener in an amount of about 0.0001 wt% to about 2.5 wt%, and at least one compound (iii) (e.g., triacetin), based on the total weight of the aerosolizable formulation, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent and tingling agent are present at a concentration of about 0.0001 wt% to about 2.5 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizer compound is defined according to the following embodiments. For example, the warming agent or tingling agent comprises vanillin (e.g., 3-phenylpropyl homovanillate), wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0184] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 2.5 wt%, a sweetener in an amount of about 0.0001 wt% to about 1 wt%, and at least one compound (iii), based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent and tingling agent are present at a concentration of about 0.0001 wt% to about 1 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizer compound is defined according to the following embodiments. For example, the warming agent or tingling agent includes vanillin (e.g., 3-phenylpropyl homovanillate), wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0185] In some embodiments, the consumable comprises one or more sensates in an amount of about 0.0001 wt% to about 1 wt%, a sweetener in an amount of about 0.0001 wt% to about 1 wt%, and at least one compound (iii), based on the total weight of the consumable, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent and tingling agent are present at a concentration of about 0.0001 wt% to about 1 wt%, wherein the weight ratio of the sensate to the sweetener is optionally greater than about 1:1 to about 3:1, the sensate, warming agent / tingling agent, and sweetener are defined according to the above embodiments, and the moisturizer compound is defined according to the following embodiments. For example, the warming agent or tingling agent includes vanillin (e.g., 3-phenylpropyl homovanillate), and wherein the sweetener is selected from acesulfame K, acesulfame K-K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. The weight ratio can be adjusted according to expression (1). The sweetener concentration can be adjusted according to expression (3).

[0186] Compound (iii)

[0187] The consumable product comprises at least one compound (iii) as a humectant. Unexpectedly, it was found that this compound can change the mouthfeel of the aerosol produced by the aerosolizable formulation or the aerosol generating system, wherein the mouthfeel is changed to replicate one or more sensations of smoking a combustible tobacco product. For example, the altered sensation can be taste, mouthfeel and / or smoking experience, as shown in the examples herein, including impact, stimulation, aerosol body and / or mouth coating.

[0188] The term "humectant" is defined above. It refers to a hygroscopic (water-absorbing) compound. In the consumables of the present disclosure, it is believed that the humectant can bind any moisture contained therein and absorb moisture from the air before and during aerosolization. This may be a contributing factor to the change in the organoleptic properties of the aerosol produced by the aerosolizable formulation using the consumable. Those skilled in the art can easily determine whether a compound is a humectant because it is a well-known chemical compound. Examples of suitable compounds are also listed below.

[0189] In addition to being a humectant, at least one compound (iii) has a boiling point of at least 200°C at atmospheric pressure. The term "atmospheric pressure" refers to 101325 Pa, equivalent to 760 mmHg. Boiling refers to the formation of vapor bubbles below the surface of a liquid and occurs when the equilibrium vapor pressure of the compound is greater than or equal to the ambient pressure. The temperature at which boiling occurs is the boiling temperature or boiling point. The boiling points of various compounds at atmospheric pressure are reported in the literature and can be readily determined by one skilled in the art. Examples of boiling points for suitable humectant compounds are also listed below.

[0190] In some embodiments, the boiling point of the humectant compound has a lower limit of about 200° C. at atmospheric pressure. This is consistent with the requirement that the consumable is suitable for use in an aerosolizable formulation or an aerosol generating system, for example, a formulation suitable for a non-combustion aerosol supply device. As described above, the humectant compound (iii) can be a contributing factor to the post-use perception of oral coating and / or oral “bodyiness” (i.e., aerosol thickness) and aerosol impact, each of which is modified to replicate the effects of smoking, for example, a traditional cigarette. Therefore, the compound can be at least partially present in an aerosol generated by an aerosolizable formulation containing the consumable of the present disclosure. The compound can be aerosolized on its own, or can be loaded into the aerosol by other components, for example, an aerosol former material or carrier as defined herein. The present disclosure is not limited in this respect.

[0191] In some embodiments, the humectant compound has a boiling point of at least about 250° C. at atmospheric pressure. In some embodiments, the humectant compound has a boiling point of at least about 280° C. In some embodiments, the humectant compound has a boiling point of at least about 300° C.

[0192] When defining the boiling point, the upper boiling point of the at least one compound (iii) is not limited. In some embodiments, the upper boiling point may depend on the maximum heating temperature of the aerosol supply device using the consumable. In some embodiments, this may be about 450°C or 400°C.

[0193] In some embodiments, the at least one compound (iii) has a boiling point of at least about 200 to about 400° C. at atmospheric pressure. In some embodiments, the at least one compound (iii) has a boiling point of at least about 250 to about 400° C. at atmospheric pressure. In some embodiments, the at least one compound (iii) has a boiling point of at least about 280 to about 400° C. at atmospheric pressure. In some embodiments, the at least one compound (iii) has a boiling point of at least about 300 to about 400° C. at atmospheric pressure.

[0194] In other embodiments, the at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200 to about 350° C. In some embodiments, the at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200 to about 325° C. In some embodiments, the at least one compound (iii) has a boiling point at atmospheric pressure of at least about 200 to about 300° C.

[0195] The following table lists some boiling points of exemplary compounds; however, the present disclosure is not limited to the compounds listed.

[0196] Compound Boiling point at atmospheric pressure (℃) triacetin 258 Triethyl citrate 294 Tributyl citrate 325 1,3-Propanediol 214

[0197] In some embodiments, compound (iii) is not propylene glycol or glycerol.

[0198] In some embodiments, at least one compound (iii) is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 Hydrocarbyl polyols, wherein the polyols comprise three or more hydroxyls.Term " hydrocarbyl " refers to the univalent group formed by removing hydrogen atoms from hydrocarbon, and the hydrocarbyl can be any one of alkyl, alkenyl, alkynyl, aryl or aralkyl.The alkyl, alkenyl, alkynyl, aryl or aralkyl can be substituted alternatively.In some embodiments, the hydrocarbyl (alkyl, alkenyl, alkynyl, aryl, aralkyl) can be unsubstituted.

[0199] As used herein with respect to moisturizers, the term "alkyl" includes saturated straight and branched chain alkane groups, which may be (single or multiple) substituted or unsubstituted. In some embodiments, the alkyl group is C 3-18 or C 4-18 In some embodiments, the alkyl group is C 3-16 or C 4-16 In some embodiments, the alkyl group is C 3-12 or C 4-12 In some embodiments, the alkyl group is C 5-18In some embodiments, the alkyl group is C 6-18 In some embodiments, the alkyl group is C 7-18 alkyl.

[0200] As used herein with respect to moisturizers, the term "alkenyl" includes unsaturated straight and branched chain olefin groups, which may be (single or multiple) substituted or unsubstituted. In some embodiments, the alkenyl group is C 3-18 or C 4-18 In some embodiments, the alkenyl group is C 3-16 or C 4-16 In some embodiments, the alkenyl group is C 3-12 or C 4-12 In some embodiments, the alkenyl group is C 5-18 In some embodiments, the alkenyl group is C 6-18 In some embodiments, the alkenyl group is C 7-18 Alkenyl.

[0201] As used herein with respect to moisturizers, the term "alkynyl" includes unsaturated straight and branched chain alkyne groups, which may be (single or multiple) substituted or unsubstituted. In some embodiments, the alkynyl group is C 3-18 or C 4-18 In some embodiments, the alkynyl group is C 3-16 or C 4-16 In some embodiments, the alkynyl group is C 3-12 or C 4-12 In some embodiments, the alkynyl group is C 5-18 In some embodiments, the alkynyl group is C 6-18 In some embodiments, the alkynyl group is C 7-18 Alkynyl.

[0202] As used herein, the term "aryl" refers to a C 6-18 In some embodiments, the aromatic group is C 6-12 Aromatic groups. Typical examples include phenyl and naphthyl, etc. In some embodiments, the aryl group is phenyl.

[0203] The term "aralkyl" is used as a combination of the above terms alkyl and aryl.

[0204] If the hydrocarbon is a branched structure with substituents thereon, the substitution may be on the hydrocarbon backbone or on the side chains. Alternatively, the substitution may be on both the hydrocarbon backbone and the side chains. Examples of suitable substitutions include hydroxyl and alkoxy.

[0205] In appropriate cases, all embodiments include all enantiomers, tautomers and geometric isomers of moisturizing compound (iii). Those skilled in the art will recognize compounds with optical properties (one or more chiral carbon atoms) or tautomeric characteristics. The corresponding enantiomers and / or tautomers can be separated / prepared by methods known in the art. Some moisturizing compound (iii) can also exist in the form of stereoisomers and / or geometric isomers, for example, they can have one or more asymmetric centers and / or geometric centers, and therefore can exist in the form of two or more stereoisomers and / or geometric isomers. In appropriate cases, all embodiments include the uses of all stereoisomers and geometric isomers of these compounds and mixtures thereof. The terms used in the claims include these forms.

[0206] In some embodiments, C4-C 18 Hydrocarbon esters are C4-C 18 Alkyl esters.

[0207] The term "ester" refers to a compound derived from an acid in which at least one of the hydrogen atoms of the acidic hydroxyl group (-OH) of the acid is replaced by an organic radical (-R). 18 Alkyl esters will have at least one hydrogen of an acidic hydroxyl group which is substituted with an organic radical (-R), provided that the total number of carbon atoms in the compound is 4 to 18. Suitable organic radical groups are known in the art. Therefore, the term "ester" includes partial esters, i.e., compounds that include both an -OH group and an -OR group. Examples include trialkyl citrates, such as triethyl citrate and tributyl citrate.

[0208] In some embodiments, C4-C 18 Alkyl esters are esters derived from carboxylic acids, such as citrates or tartaric acid esters, preferably C4-C 18 In some embodiments, C4-C 18 The trialkyl ester is a trialkyl citrate, for example, triethyl citrate or tributyl citrate.

[0209] The term "ester" also includes glycerides, i.e., esters formed from glycerol and fatty acids. 18 Hydrocarbyl esters are glycerides. Glycerides are known in the art to be hydrophobic. Glycerol has three hydroxyl functional groups that can esterify with one, two or three fatty acids to form mono-, di- and tri-glycerides. The fatty acid alkyl groups of these structures are different because they can contain different carbon numbers, different unfilled senses and different configurations and positions of olefins. Yet, they are connected to glycerol with a chemical core structure.

[0210] In some embodiments, the C4-C 18 The hydrocarbyl ester is a mono-, di- or triglyceride, preferably a di- or triglyceride, such as a C4-C 16 A di- or triglyceride, for example, diacetin or triacetin. A particularly preferred embodiment is one in which the glyceride is a triglyceride, such as C4-C 16 Triglyceride, this article takes triacetin as an example.

[0211] Glyceryl triacetate is an organic compound whose chemical formula is shown in Appendix 1. It is classified as a triglyceride, a three-ester of glycerol, and is a common food additive, for example, as a solvent in condiments and for its moisturizing properties. It can be obtained from various commercial sources. In some embodiments, the consumable can include an amount of one or more sensates in triacetin, wherein the triacetin is present in an amount of 50% by weight or more of the consumable, such as 60% by weight or more of the consumable, and preferably 70% by weight or more.

[0212] In some embodiments, C4-C 18 The hydrocarbyl ester may be a compound of formula (II):

[0213]

[0214] wherein R1 is alkyl, alkenyl, alkynyl, aryl or aralkyl, preferably alkyl or alkenyl;

[0215] wherein R2, R3 and R4 are each independently selected from H, OH, alkyl, alkenyl, alkoxy or COOR' groups, alkyl and alkenyl groups being optionally substituted with OH, alkoxy or COOR' groups, wherein each R' is independently alkyl or alkenyl, provided that the sum of the carbon atoms of R1, R2, R3, R4 and R' is 4 to 18. Alkyl, alkenyl, alkynyl, aryl and aralkyl groups are as described above.

[0216] In some embodiments, at least one of R2, R3 and R4 is an alkyl, alkenyl, alkoxy or COOR' group, and the alkyl and alkenyl groups are optionally substituted with OH, alkoxy or COOR' groups, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4 and R' is 4-18.

[0217] In some embodiments, at least one of R2, R3, and R4 is a COOR' group or an alkyl or alkenyl group substituted with a COOR' group, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4, and R' is 5-18.

[0218] In some embodiments, R1 is an alkyl or alkenyl group, and R2, R3, and R4 are each independently selected from H, OH, an alkyl, an alkenyl, or a COOR' group, and the alkyl and alkenyl groups are optionally substituted with OH or COOR' groups, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4, and R' is 4-18.

[0219] In some embodiments, at least one of R2, R3 and R4 is an alkyl, alkenyl, alkoxy or COOR' group, and the alkyl and alkenyl groups are optionally substituted with OH, alkoxy or COOR' groups, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4 and R' is 5-18.

[0220] In some embodiments, at least one of R2, R3, and R4 is a COOR' group or an alkyl or alkenyl group substituted with COOR', wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4, and R' is 5-18.

[0221] In some embodiments, at least two of R2, R3, and R4 are COOR' groups or alkyl or alkenyl groups substituted with COOR' groups, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms of R1, R2, R3, R4, and R' is 7-18.

[0222] In some embodiments, C3-C 18 Hydrocarbon diols are C3-C 18 Alkyl or alkenyl diol, preferably C3-C 18 In some embodiments, C3-C 18 Hydrocarbon diols are C3-C 16 Alkyl glycol, preferably C3-C 12 Alkyl glycol, this article takes 1,3-propylene glycol as an example.

[0223] In some embodiments, C4-C 18 Hydrocarbon polyols are C4-C 18 Alkyl or alkenyl polyols, preferably C4-C 18 In some embodiments, C4-C 18 Hydrocarbon polyols are C4-C 16 Alkyl polyols, preferably C4-C 12 Alkyl polyols.

[0224] In some embodiments, C4-C 18 Hydrocarbyl polyols are C4-C 18 Alkyl or alkenyl polyols, preferably C4-C4 having up to six hydroxyl groups 18In some embodiments, C4-C 18 Hydrocarbyl polyols are C4-C 16 Alkyl polyols, preferably C4-C 12 Alkyl polyols.

[0225] In some embodiments, at least one compound (iii) is selected from C4-C 18 Alkyl esters, C3-C 18 Alkyl or alkenyl diols and C4-C 18 An alkyl or alkenyl polyol having at least three hydroxyl groups.

[0226] In some embodiments, at least one compound (iii) is selected from C4-C 18 Alkyl esters, C3-C 18 Alkyl glycol and C4-C 18 An alkyl polyol having at least three hydroxyl groups.

[0227] In some embodiments, at least one compound (iii) is selected from C4-C 18 Alkyl esters, C3-C 18 Alkyl glycol and C4-C 18 Alkyl polyols, the polyols having three to six hydroxyl groups.

[0228] In some embodiments, at least one compound (iii) is selected from the group consisting of compounds of formula (II) as defined above, C3-C 18 Alkyl glycol and C4-C 18 Alkyl polyols, the polyols having three to six hydroxyl groups.

[0229] In some embodiments, at least one compound (iii) is selected from C4-C 18 Glycerides, C4-C 18 Hydrocarbon citrate, C3-C 18 Hydrocarbon diols, C4-C 18 Hydrocarbyl triols.

[0230] In some embodiments, at least one compound (iii) is selected from C4-C 16 Triglycerides, C4-R 16 Hydrocarbon citrate and C3-C 16 Hydrocarbon diols.

[0231] In some embodiments, at least one compound (iii) is selected from C4-C 16 Triglycerides, C4-R 16 Alkyl citrate and C3-C 16 Alkyl glycol.

[0232] Thus, the present invention provides a consumable product for an aerosolizable formulation, wherein the consumable product comprises:

[0233] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 5 wt % based on the total weight of the consumable;

[0234] (ii) sweeteners; and

[0235] (iii) at least one compound as a humectant selected from the group consisting of C4-C 18 Alkyl esters, C3-C 18 Alkyl or alkenyl diols and C4-C 18 An alkyl or alkenyl polyol having at least three hydroxyl groups, the at least one compound being present in an amount of 50 wt % or more of the consumable.

[0236] In some embodiments, the consumable comprises:

[0237] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 3 wt % based on the total weight of the consumable;

[0238] (ii) sweeteners; and

[0239] (iii) at least one compound which is a humectant selected from the group consisting of C4-C 18 Alkyl esters, C3-C 18 Alkyl glycol and C4-C 18 An alkyl polyol having at least three hydroxyl groups, the at least one compound being present in an amount of 60 wt % or more of the consumable.

[0240] In some embodiments, the consumable comprises:

[0241] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 2.5 wt % based on the total weight of the consumable;

[0242] (ii) sweeteners; and

[0243] (iii) at least one compound which is a humectant selected from the group consisting of C4-C 18 Alkyl esters, C3-C 18 Alkyl glycol and C4-C 18An alkyl polyol having three to six hydroxyl groups, the at least one compound being present in an amount of 70 wt % or more of the consumable.

[0244] In some embodiments, the consumable comprises:

[0245] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent, said warming or tingling agent being present in a concentration of at least about 0.0001 wt % to about 1 wt % based on the total weight of the consumable;

[0246] (ii) sweeteners; and

[0247] (iii) at least one compound as a humectant selected from the group consisting of compounds of formula (II) as defined above, C3-C 18 Alkyl glycol and C4-C 18 An alkyl polyol having three to six hydroxyl groups, the at least one compound being present in an amount of 80 wt % or more of the consumable.

[0248] In any of the above embodiments, at least one compound (iii) may be selected from a compound of formula (II) or C3-C 18 Preferably, at least one compound (iii) may be selected from C4-C 16 Triglycerides, C4-R 16 Hydrocarbon citrate and C3-C 16 Hydrocarbon diols.

[0249] Other components

[0250] In addition to the above-mentioned sensory agents, sweeteners and moisturizing agents (such as triacetin), the consumables may also include one or more other components. The concentration of the one or more other components is not limited, and in some embodiments, it can be about 0.001wt% to about 10wt% of the consumables. In some embodiments, the consumables also include one or more compounds selected from 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furanthiol, fenugreek lactone (sotolone), 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone, β-damascenone, 2,6-dimethoxyphenol, geraniol (geraniol), dimethyl trisulfide (dimethyl trisulphide), 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylvaleric acid, butyric acid, β-damascenone, β-ionone, α-ionol, β-cyclocitral, safranal, maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione (coronol), mesifurane, maple furanone The above concentration ranges apply to compounds containing one or more of these compounds.

[0251] In some embodiments, the one or more compounds include at least one compound selected from 4-propylphenol, 4-ethyl-2-methoxyphenol, 3-ethylphenol, 2,6-dimethoxyphenol, trigonelline, and / or 2,4-lutidine.

[0252] In some embodiments, the one or more compounds are selected from 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furylthiol, fenugreek lactone, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone, β-damascenone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, or a combination thereof. In a preferred embodiment, the consumable comprises four or five compounds selected from 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furylthiol, fenugreek lactone, 2,4-lutidine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone, β-damascenone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, and 3-methylbutanal.

[0253] Particularly preferred are:

[0254] (i) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furylthiol, and trigonelline lactone;

[0255] (ii) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, and trigonelline lactone;

[0256] (iii) 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine;

[0257] (iv) trigonelline lactone, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone;

[0258] (v) 2-furylthiol, 2,4-dimethylpyridine, 3-ethylphenol, β-damascenone;

[0259] (vi) 2-ethyl-3,5-dimethylpyrazine, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide;

[0260] (vii) 2-furylthiol, trigonelline lactone, 2,4-lutidine, 3-ethylphenol, dimethyl trisulfide; or

[0261] (viii) 2-Furylmethanethiol, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine, furanone, and 3-methylbutanal.

[0262] In some embodiments, at least one compound is selected from Compounds A, B, C, D, E, and combinations thereof. Compounds A, B, C, D, and E are each defined as follows.

[0263] Compound A

[0264] In some embodiments, A is at least one compound selected from acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylvaleric acid, and butyric acid. In some embodiments, compound A is 3-methylbutyric acid, also known as isovaleric acid. In some embodiments, compound A is acetic acid. In some embodiments, compound A is 3-methylvaleric acid, also known as 3-methylvaleric acid. In some embodiments, compound A is 2-methylbutyric acid. In some embodiments, compound A is butyric acid, also known as butyric acid. In some embodiments, A is at least acetic acid and 2-methylbutyric acid. Preferably, A is at least one compound selected from acetic acid, 3-methylbutyric acid, and 3-methylvaleric acid.

[0265] Compound B

[0266] In some embodiments, B is at least one compound selected from β-damascenone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, and safranal. In some embodiments, B is at least two compounds selected from β-damascenone, β-damascenone and β-ionone, α-ionone, α-ionol, β-cyclocitral, and safranal. In some embodiments, B is at least β-damascenone, β-damascenone, and β-ionone. Preferably, B is at least one compound selected from β-damascenone, β-damascenone, and β-ionone.

[0267] Compound C

[0268] In some embodiments, C is at least one compound selected from maltol, ethyl maltol and trigonelline lactone. In some embodiments, C is at least two compounds selected from maltol, ethyl maltol and trigonelline lactone. Preferably, C is at least one compound selected from maltol and trigonelline lactone.

[0269] Compound D

[0270] In some embodiments, D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione, homomethylfuran, maple furanone, 4-propyl-2-methoxyphenol, benzaldehyde, and 4-allyl-2,6-dimethoxyphenol. Preferably, D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, and phenylacetic acid.

[0271] Compound E

[0272] In some embodiments, E is at least one compound selected from 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one. Preferably, E is 3-methyl-2,4-nonanedione.

[0273] In some embodiments, the consumable comprises three or more compounds selected from compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein. In some embodiments, the consumable comprises four or more compounds selected from compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein. In some embodiments, the consumable comprises at least compounds A, B, C, and D, wherein each of A, B, C, and D is as defined herein. In some embodiments, the consumable comprises a compound from each of compounds A, B, C, D, and E, wherein each of A, B, C, D, and E is as defined herein.

[0274] In some embodiments, when two or more different A compounds are present, they may be selected from two or more of the group consisting of acetic acid, 3-methylbutanoic acid, 3-methylvaleric acid, 2-methylbutanoic acid, and butanoic acid. In some embodiments, when two or more different A compounds are present, they are at least butanoic acid and 3-methylbutanoic acid.

[0275] In addition to compounds A, B, C and D, the consumable product of the present invention may also contain one or more of the following compounds belonging to component E: 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one.

[0276] When present, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B components): A:B (5-10):1; C:B (5-10):1; and D:B (10-15):1. In one embodiment, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B compounds): A:B (1-5):1; C:B (1-5):1; and D:B (5-10):1. In one embodiment, compounds A, C, and D may be present in the following weight ratios relative to compound B (total B compounds): A:B (5-10):1; C:B (15-25):1; and D:B (5-10):1.

[0277] Aerosolizable preparation or aerosol generating system

[0278] In some embodiments, an aerosolizable formulation for an aerosol delivery system is provided, comprising a consumable as described herein, a carrier, and optionally nicotine. In some embodiments, the formulation comprises a consumable as defined herein, a carrier, and nicotine. In some embodiments, the formulation comprises at least about 1 wt %, such as at least about 5 wt %, preferably at least about 10 wt % of the consumable. The consumable may be present in the formulation in an amount of no more than about 25 wt %, such as no more than about 20 wt %, preferably no more than about 15 wt %.

[0279] In some embodiments, the consumable may be present in the formulation in an amount of about 1 wt % to about 25 wt %, such as about 5 wt % to about 20 wt %, preferably about 10 wt %-15 wt %.

[0280] The aerosolizable formulation can be in various forms, including gel, liquid, or solid. In some preferred embodiments, the aerosolizable formulation is a liquid. In other preferred embodiments, the aerosolizable formulation is a gel. In some embodiments, the consumable is in the form of a liquid or a gel.

[0281] carrier

[0282] When the aerosolizable formulation is a liquid, the carrier of the formulation can be any suitable solvent so that the formulation can be vaporized for use. In some embodiments, the solvent is selected from glycerol, propylene glycol, water, and mixtures thereof. In some embodiments, the solvent is selected from glycerol, propylene glycol, and mixtures thereof. In some embodiments, the solvent is at least glycerol. In some embodiments, the solvent consists essentially of glycerol. In some embodiments, the solvent consists of glycerol. In some embodiments, the solvent is at least propylene glycol. In some embodiments, the solvent consists essentially of propylene glycol. In some embodiments, the solvent consists of propylene glycol. In some embodiments, the solvent is at least a mixture of propylene glycol and glycerol. In some embodiments, the solvent consists essentially of a mixture of propylene glycol and glycerol. In some embodiments, the solvent consists of a mixture of propylene glycol and glycerol.

[0283] The carrier of the preparation can be present in any suitable amount. In some embodiments, the carrier is present in an amount of about 50wt% to about 99wt% based on the gross weight of the preparation, preferably about 70wt% to about 98wt% based on the gross weight of the preparation, and preferably about 70wt% to about 95wt% based on the gross weight of the preparation.

[0284] In some embodiments, the formulation is a liquid and comprises about 1 wt % to about 25 wt % of the consumable, about 50 wt % to about 99 wt % of a carrier, and optionally nicotine, such as about 5 wt %-20 wt % of the consumable, about 60 wt %-98 wt % of a carrier, and optionally nicotine, preferably about 10 wt %-15 wt % of the consumable, about 70 wt %-95 wt % of a carrier, and optionally nicotine.

[0285] nicotine

[0286] When the formulation is aerosolized and inhaled by the user, nicotine can be provided in any suitable amount depending on the desired dosage. In some embodiments, nicotine is present in an amount of no more than about 6 wt % based on the total weight of the formulation. In some embodiments, nicotine is present in an amount of about 0.1 wt % to about 6 wt % based on the total weight of the formulation, such as in an amount of about 0.5 wt % to about 6 wt % based on the total weight of the formulation, preferably in an amount of about 0.5 wt % to about 5 wt % based on the total weight of the formulation.

[0287] In some embodiments, the aerosolizable formulation is a liquid and can comprise about 1 wt % to about 25 wt % of a consumable (wherein the consumable is defined according to the above embodiments), about 50 wt % to about 99 wt % of a carrier, and about 0.1 wt %-6 wt % of nicotine.

[0288] In some embodiments, the aerosolizable formulation is a liquid and can comprise about 5 wt % to about 20 wt % of a consumable (wherein the consumable is defined according to the above embodiments), about 60 wt % to about 98 wt % of a carrier, and about 0.5 wt % to about 6 wt % of nicotine.

[0289] In some preferred embodiments, the aerosolizable formulation is a liquid and may comprise from about 10 wt % to about 15 wt % of a consumable (wherein the consumable is defined according to the above embodiments), from about 70 wt % to about 95 wt % of a carrier, and from about 0.5 wt % to about 5 wt % of nicotine.

[0290] In some embodiments, in addition to nicotine (as an active agent), the preparation may also contain one or more acids. In some embodiments, the one or more acids may be one or more organic acids. In some embodiments, the one or more acids may be one or more organic acids selected from benzoic acid, levulinic acid, malic acid, maleic acid, fumaric acid, citric acid, lactic acid, acetic acid, succinic acid, and mixtures thereof. When included in the preparation in combination with nicotine, the one or more acids may provide a preparation in which nicotine is at least partially protonated (e.g., monoprotonated and / or diprotonated). In some preferred embodiments, the one or more acids include benzoic acid and / or levulinic acid. In some preferred embodiments, the one or more acids include benzoic acid.

[0291] Adhesives

[0292] In some embodiments, an aerosolizable formulation or aerosol generating system is provided, comprising a consumable as described herein, an aerosol former material, one or more binders, and optionally a botanical material. In a preferred embodiment, the binder is composed of one or more gelling agents.

[0293] Suitably, the aerosolizable formulation or aerosol generating system comprises from about 2 wt% to about 80 wt% of a binder, for example, from about 5 wt%, 7 wt%, 10 wt%, 15 wt%, 17 wt%, 20 wt% or 25 wt% to about 70 wt%, 60 wt%, 50 wt%, 45 wt%, 40 wt%, 35 wt% or 30 wt% of one or more binders (all calculated on a dry weight basis). For example, the aerosolizable formulation or aerosol generating system may comprise from about 5 wt% to 70 wt%, 7 wt% to 60 wt%, 10 wt% to 50 wt%, 15 wt% to 45 wt%, 17 wt% to 40 wt%, 20 wt% to 35 wt% or 25 wt% to 30 wt% of a binder.

[0294] In some embodiments, the one or more adhesives include one or more gelling agents. In some embodiments, the one or more adhesives consist of one or more gelling agents. In some embodiments, the gelling agent includes a hydrocolloid.

[0295] In some embodiments, the one or more binders include (or are) one or more compounds selected from polysaccharide gelling agents, such as alginates, pectins, starches or derivatives thereof, cellulose or derivatives thereof, pullulan, carrageenan, agar and agarose; gelatin; gums, such as xanthan gum, guar gum and gum arabic; silicon dioxide or silicone compounds such as PDMS and sodium silicate; clays, such as kaolin; and polyvinyl alcohol.

[0296] In some embodiments, one or more adhesives include (or are) one or more polysaccharide gelling agents. In some embodiments, the polysaccharide gelling agent is selected from alginate, pectin, starch or its derivatives, or cellulose or its derivatives. In some embodiments, the polysaccharide gelling agent is selected from alginate and cellulose derivatives.

[0297] In some embodiments, the one or more adhesives are polysaccharide gelling agents, optionally, wherein the polysaccharide gelling agent is selected from alginates and cellulose derivatives. In some embodiments, the polysaccharide gelling agent is alginate. In some embodiments, the alginate is sodium alginate.

[0298] In some embodiments, the polysaccharide gelling agent is a cellulose derivative. Without wishing to be bound by theory, it is believed that such a gelling agent does not react with calcium ions to form crosslinks. In some embodiments, the binder is not crosslinked. The absence of crosslinks in the gelling agent can facilitate faster delivery of the consumable product (and any optional other active substances and / or fragrances) from the aerosolizable formulation or aerosol generating system.

[0299] Examples of cellulose binders (also referred to herein as cellulose gelling agents or cellulose derivatives) include, but are not limited to, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose or its derivative is selected from hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose (CMC), hydroxypropyl methyl cellulose (HPMC), methyl cellulose, ethyl cellulose, cellulose acetate (CA), cellulose acetate butyrate (CAB), and cellulose acetate propionate (CAP). In some embodiments, the cellulose derivative is CMC. For example, in some embodiments, the binder includes (or is) one or more of alginate, pectin, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, pullulan, xanthan gum, guar gum, carrageenan, agarose, gum arabic, fumed silica, PDMS, sodium silicate, kaolin, and polyvinyl alcohol.

[0300] In some embodiments, the binder includes (or is) one or more of hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, guar gum, gum arabic, alginate and / or pectin.

[0301] In some cases, the binder comprises (or is) alginate and / or pectin and can be combined with a solidifying agent (such as a calcium source) during formation of the aerosolizable formulation or aerosol generating system. In some cases, the binder can include calcium cross-linked alginate and / or calcium cross-linked pectin.

[0302] In some embodiments, the binder includes (or is) alginate, optionally wherein the alginate is present in the aerosolizable formulation in an amount of about 5 wt%-70 wt%, 7 wt%-60 wt%, 10 wt%-50 wt% or 15 wt%-45 wt% (calculated on a dry weight basis) of the aerosolizable formulation or aerosol generating system.

[0303] In some embodiments, alginate is the only binder present in the aerosolizable formulation / aerosol generating system. In other embodiments, the binder includes alginate and at least one other binder, for example, pectin. In a particular embodiment, the binder is carboxymethyl cellulose, optionally wherein the carboxymethyl cellulose (CMC) is present in an amount of about 2wt%-80wt%, for example, about 5wt%-70wt%, 10wt%-60wt%, 15wt%-50wt%, 17wt%-45wt%, 20wt%-40wt% or about 30wt%. In some embodiments, CMC is the only binder present in the aerosolizable formulation / aerosol generating system.

[0304] filler

[0305] The aerosolizable formulation or aerosol-generating system may also include a filler. For example, if high levels of aerosol-forming material are present, the use of a filler may help reduce the viscosity of the aerosolizable formulation / aerosol-generating system. Suitably, the aerosolizable formulation / aerosol-generating system comprises from about 2 wt% to about 60 wt% of a binder and any optional filler.

[0306] In some embodiments, the filler is present in an amount of less than about 50 wt %, such as about 1 wt % to 50 wt %, or 5 wt % to 40 wt %, or 5 wt % to 30 wt %, or 10 wt % to 20 wt % of the filler. In other embodiments, the filler is present in an amount of less than 20 wt %, suitably less than 10 wt % or less than 5 wt %. In some cases, the aerosolizable formulation / aerosol generating system comprises less than 1 wt % of filler, and in some cases, comprises no filler.

[0307] Fillers, if present, may include one or more inorganic fillers such as calcium carbonate, perlite, vermiculite, diatomaceous earth, silica gel, magnesium oxide, magnesium sulfate, magnesium carbonate, and suitable inorganic adsorbents such as molecular sieves. Fillers may include one or more organic filler materials such as wood pulp; tobacco pulp; hemp fiber; starch and starch derivatives such as maltodextrin; chitosan; and cellulose and cellulose derivatives such as ground cellulose, microcrystalline cellulose, and nanocrystalline cellulose. In particular instances, the aerosolizable formulation does not contain calcium carbonate, such as chalk.

[0308] In embodiments that include a filler, the filler is fibrous. For example, the filler can be a fibrous organic filler material, such as wood pulp, tobacco pulp, hemp fiber, cellulose, or a cellulose derivative. In some embodiments, the fibrous organic filler material can be wood pulp, hemp fiber, cellulose, or a cellulose derivative. In some embodiments, the fibrous filler is wood pulp. Without wishing to be bound by theory, it is believed that the addition of a fibrous filler to the aerosolizable formulation can increase the tensile strength of the material. In instances where the aerosolizable formulation or aerosol generating system is provided in sheet form, this can be particularly advantageous, for example when the sheet wraps around a rod of aerosolizable or aerosol generating material.

[0309] Plant preparation materials

[0310] In some embodiments, the aerosolizable formulation or aerosol generating system comprises a botanical material.

[0311] The term "botanical" includes any material derived from a plant, including, but not limited to, extracts, leaves, bark, fiber, stems, roots, seeds, flowers, fruits, pollen, husks, shells, and the like. Alternatively, the material may comprise a synthetically derived active compound naturally occurring in the plant. The material may be in the form of a liquid, gas, solid, powder, dust, crushed particles, granules, pellets, chips, strips, sheets, and the like.

[0312] Examples of botanicals are tobacco, eucalyptus, star anise, hemp, cocoa, fennel, lemongrass, mint, spearmint, rooibos, chamomile, flax, ginger, ginkgo biloba, hazelnut, hibiscus, bay laurel, liquorice (licorice), matcha, mate, orange peel, papaya, rose, sage, tea such as green or black tea, thyme, cloves, cinnamon, coffee, aniseed (anise), basil, bay leaf, cardamom, coriander, cumin, nutmeg, oregano, paprika, rosemary, saffron, lavender, lemon peel, mint, juniper , elderflower, vanilla, wintergreen, basil, turmeric (curcuma), turmeric root (turmeric), sandalwood, coriander leaf, bergamot, orange blossom, myrtle, black currant, valerian, pimento, mace, damien, marjoram, olive, lemon balm, lemon basil, chives, caraway, verbena, tarragon, geranium, mulberry, ginseng, theanine, theophylline, maca, ashwagandha, damiana, guarana, chlorophyll, baobab, or any combination thereof. The mint may be selected from the following mint varieties: field mint (Mentha arvensis), cultivated mint varieties (Mentha cv), Egyptian mint (Mentha niliaca), European peppermint (Mentha piperita), lemon mint (Mentha piperita citrata cv), cultivated peppermint varieties (Mentha piperita cv), spearmint (Mentha spicata crispa), heartleaf spearmint (Mentha cordifolia), horse mint (Metha longifolia), pineapple mint (Mentha suaveolens variegata), lip calyx mint (Mentha pulegium), cultivated spearmint varieties (Menthaspicata cv) and apple mint (Mentha suaveolens).

[0313] In some embodiments, the botanical preparation is tobacco. In some embodiments, the botanical preparation is selected from eucalyptus, star anise, cocoa, and hemp. In some embodiments, the botanical preparation is selected from rooibos tea and fennel.

[0314] Aerosol-forming material

[0315] The aerosol-forming agent material may include one or more components capable of forming an aerosol. Suitably, the aerosolizable formulation or aerosol generating system may include about 5 wt % to about 30 wt %, for example, about 7 wt %, 10 wt % or 12 wt % to about 15 wt %, 17 wt %, 20 wt % or 25 wt % of aerosol-forming agent material (calculated on a dry weight basis). In some embodiments, the aerosolizable formulation or aerosol generating system may include about 5 wt %-25 wt % of aerosol-forming agent material. In some embodiments, the aerosolizable formulation or aerosol generating system may include about 5 wt %-20 wt %, for example, about 5 wt %-15 wt % of aerosol-forming agent material. In some embodiments, the aerosolizable formulation or aerosol generating system may include about 10 wt %-20 wt % of aerosol-forming agent material.

[0316] In some embodiments, the aerosol former material may include one or more of the following: glycerol, propylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, 1,3-butylene glycol, ethyl vanillate, ethyl laurate, diethyl suberate, benzyl benzoate, benzyl phenylacetate, tributyrin, lauryl acetate, lauric acid, myristic acid, and propylene carbonate.

[0317] In some embodiments, the aerosol-forming material can include one or more of propylene glycol or glycerol. In some cases, the aerosol-forming material comprises, consists essentially of, or consists of glycerol or a mixture of glycerol and propylene glycol.

[0318] In some embodiments, the aerosol former material comprises a mixture of glycerin and propylene glycol in a weight ratio of glycerin to propylene glycol of about 3:1-1:3, about 2:1-1:2, about 1.5:1-1:1.5, about 55:45-45:55, or about 45:55.

[0319] The aerosol-forming material can act as a plasticizer. If the plasticizer content is too high, the aerosolizable formulation may absorb water, resulting in the material not providing an adequate consumer experience during use. If the plasticizer content is too low, the aerosolizable formulation may become brittle and easily break. The plasticizer content specified herein provides flexibility to the aerosolizable formulation, allowing sheets of the aerosolizable formulation or aerosol-generating composition to be wound onto a spool, which is suitable for manufacturing aerosol-generating articles.

[0320] Other components

[0321] Aerosolizable preparation or aerosol generating system can comprise one or more other components. Specifically, one or more other ingredients can be selected from one or more activating agents, and / or one or more functional components. In some embodiments, the activating agent is a physiologically active agent, and can be selected from nicotine, nicotine salts (for example, nicotine bitartrate / nicotine bitartrate), nicotine-free tobacco substitutes, other alkaloids such as caffeine, or a mixture thereof. In other embodiments, the aerosolizable preparation or aerosol generating system are nicotine-free, which means that nicotine is not included in the aerosolizable preparation or aerosol generating system.

[0322] "Active agent" refers to an agent that has a biological effect, such as a sensory and / or physiological effect, on a subject when an aerosol is inhaled. In one aspect, "active agent" refers to an agent that has a physiological effect on a subject when an aerosol is inhaled. In some cases, the active agent can be a fragrance. The active agent can also be selected from nutraceuticals, nootropics, psychoactive agents, and sensory agents, wherein sensory agents are sensory agents other than those present in consumables. In some embodiments, the active agent is selected from nutraceuticals, nootropics, and psychoactive drugs. The active substance can be naturally occurring or synthetically obtained.

[0323] The active agent may include, for example, nicotine, caffeine, taurine, theophylline, vitamins such as B6 or B12 or C, melatonin, or components, derivatives, or combinations thereof. The active agent may include one or more components, derivatives, or extracts of tobacco or another plant. In some embodiments, the active agent includes caffeine, melatonin, or vitamin B12. The one or more active agents may be selected from nicotine, botanicals, and mixtures thereof. The one or more active agents may be synthetic or natural. The active agent may be a botanical extract, such as the Nicotiana plant extracts discussed above. In one aspect, the active agent is at least nicotine. In one aspect, as described above, the active agent consists of nicotine and / or its salts.

[0324] As described herein, the active agent may comprise or be derived from one or more botanicals or components, derivatives, or extracts thereof. In some embodiments, the active agent comprises or is derived from one or more botanicals or components, derivatives, or extracts thereof, and the botanical is tobacco. In some embodiments, the active agent comprises or is derived from one or more botanicals or components, derivatives, or extracts thereof, and the botanical is selected from eucalyptus, aniseed, cocoa, and hemp. In some embodiments, the active agent comprises or is derived from one or more botanicals or components, derivatives, or extracts thereof, and the plant is selected from Rooibos tea and fennel.

[0325] When nicotine is present in the formulation, it can be present in a protonated and / or unprotonated form. In some embodiments, the formulation comprises an unprotonated form of nicotine and a monoprotonated form of nicotine. Small amounts of diprotonated nicotine may also be present. In one aspect, the formulation comprises an unprotonated form of nicotine, a monoprotonated form of nicotine, and a diprotonated form of nicotine.

[0326] As discussed herein, the formulation may additionally comprise an unprotonated form of nicotine and a protonated form of nicotine. Those skilled in the art will appreciate that the protonated form of nicotine can be prepared by reacting the unprotonated form of nicotine with an acid. The acid is one or more suitable acids, such as an organic acid. In some embodiments, the acid is a carboxylic acid. The carboxylic acid can be any suitable carboxylic acid. In some embodiments, the acid is a monocarboxylic acid. In some embodiments, the acid is selected from acetic acid, benzoic acid, levulinic acid, lactic acid, formic acid, citric acid, pyruvic acid, succinic acid, tartaric acid, oleic acid, sorbic acid, propionic acid, phenylacetic acid, and mixtures thereof. In some embodiments, the acid is benzoic acid and / or levulinic acid. In some embodiments, the acid is benzoic acid.

[0327] In alternative embodiments, the aerosolizable formulation may be free of organic or inorganic acids and their corresponding salts. For example, the aerosolizable formulation may be free of carboxylic acids and free of phosphoric acid.

[0328] If present, the content of organic acid can vary. Based on the gross weight of preparation, described preparation can comprise the organic acid of about 0.01wt% to about 10wt%, exists with the form of one or more organic acids. In some embodiments, based on the gross weight of preparation, described preparation comprises at least about 0.01%, at least about 0.1wt%, about 0.2wt%, about 0.3wt%, about 0.4wt%, about 0.5wt%, about 0.6wt%, about 0.7wt%, about 0.8wt%, about 0.9wt%, about 1wt%, about 2wt%, about 3wt%, about 4wt%, about 5wt%, about 6wt%, about 7wt%, about 8wt%, about 9wt% or at least about 10wt% organic acid. In some preferred embodiments, said preparation comprises the organic acid of about 0.01wt% to about 5wt%. For example, said preparation comprises the organic acid of the amount of described preparation weight about 0.1wt% to about 2.5wt%. In the case of addition of an organic acid salt (eg, citric acid anhydrate), weight percentages are calculated based on the weight of the free acid, excluding any counterions that may be present.

[0329] In some embodiments, the other components are selected from "flavors" and / or "flavorants," which, where permitted by local regulations, may be used to create a desired taste or aroma in products for adult consumers. Those skilled in the art will recognize that, in the context of this disclosure, flavors or flavorants are not sensate compounds as defined herein. In some cases, the flavoring or flavoring agent may include one or more extracts (e.g., licorice, hydrangea, Japanese white magnolia leaf, chamomile, fenugreek, clove, Japanese mint, fennel, cinnamon, vanilla, wintergreen, cherry, berry, peach, apple, Drambuie, bourbon, scotch, whiskey, spearmint, mint, lavender, cardamom, celery, cascarilla, nutmeg, sandalwood, bergamot, geranium, honey essence, rose oil, vanilla, lemon oil, orange oil, cassia seed, caraway, cognac, jasmine, ylang ylang, sage, fennel, bell pepper, anise, coriander, coffee and other additives such as charcoal, chlorophyll, minerals or botanicals. They can be imitation, synthetic or natural ingredients or blends thereof. They can be in any suitable form, for example, oil, liquid or powder.

[0330] Flavorings may be added to the aerosolizable formulation as part of a so-called "flavor block," wherein one or more flavorings are blended together and subsequently added to the aerosolizable material. The "flavor block" may optionally include one or more sensate compounds as defined herein.

[0331] Where present, the flavoring agent can be included in the formulation in an amount of about 10 wt %, such as up to about 5 wt %, such as up to about 1 wt %, of the formulation weight. In some embodiments, the flavoring agent is present in an amount of about 0.01 wt % to about 5 wt %, preferably about 0.1 wt % to 2.5 wt %, and more preferably about 0.25 wt % to 1 wt %, of the formulation weight.

[0332] One or more other functional components can include one or more of a colorant, a preservative, a binder and / or a filler. For example, a filler can achieve multiple functions, such as enhancing certain organoleptic properties, such as texture and mouthfeel, enhancing the cohesion or compressibility of the product, etc. For more details, see above. In some embodiments, a binder (or combination of binders) can be used in the product in an amount that is enough to provide required physical properties and physical integrity for the product. For more details, see above. A colorant can be used in an amount that is enough to provide required physical properties for the product.

[0333] In some embodiments, the aerosolizable material comprises less than 12% w / w water. In some embodiments, the aerosolizable material comprises less than 11% w / w water. In some embodiments, the aerosolizable material comprises less than 10% w / w water. In some embodiments, the aerosolizable material comprises less than 5% w / w water. In some embodiments, the aerosolizable material comprises less than 1% w / w water. In some embodiments, the aerosolizable material comprises less than 0.5% w / w water. In some embodiments, the aerosolizable material is substantially free of water.

[0334] Concentration and weight ratio

[0335] In some embodiments, the aerosolizable formulation or aerosol generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 5 wt % of one or more sensates and from greater than about 1 wt % to less than about 35 wt % of at least one compound (iii), wherein at least one sensate is a warming or tingling agent, or a sweetener, the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of the sensate to the sweetener is from greater than about 1:1 to about 3:1. This weight ratio can be adjusted according to the above expression (1), i.e., sweetness potency.

[0336] In some embodiments, an aerosolizable formulation or an aerosol generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 3 wt % of one or more sensates and from greater than about 1 wt % to less than about 30 wt % of at least one compound (iii), wherein at least one sensate is a warming or tingling agent, or a sweetener, the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of sensate to sweetener is from greater than about 1:1 to about 3:1. This weight ratio can be adjusted according to the above expression (1), i.e., sweetness potency.

[0337] In some embodiments, an aerosolizable formulation or an aerosol generating system comprises a consumable as defined herein, wherein the formulation or system comprises from about 0.0001 wt % to about 2.5 wt % of one or more sensates and from greater than about 1 wt % to less than about 20 wt % of at least one compound (iii), wherein at least one sensate is a warming or tingling agent, or a sweetener, the wt % values being based on the total weight of the formulation or system, optionally wherein the weight ratio of sensate to sweetener is from greater than about 1:1 to about 3:1. This weight ratio can be adjusted according to the above expression (1), i.e., sweetness potency.

[0338] According to the above embodiments, these embodiments can also be defined by the consumables, carriers and / or nicotine concentrations. It should be understood that for the sake of simplicity, these features will not be repeated here.

[0339] Since the aerosolizable formulation and aerosol generating system embodiments include consumables as defined herein, it will be understood that the components of the consumables, such as sensates, include warming agents, tingling agents, and optionally cooling agents, sweeteners, at least one compound (iii), and any other components as described above. For the sake of brevity, this definition will not be repeated here, but it applies equally to the description of the aerosolizable formulation and aerosol generating system.

[0340] The one or more defined sensates are present in the formulation in an amount of about 0.0001 wt % to about 5 wt %, based on the total weight of the formulation. It will be understood by those skilled in the art that this concentration range applies to the total amount of sensates, such as warming or tingling agents and optional cooling agents. A concentration range of about 0.0001 wt % to about 5 wt % also applies to the above definition of the one or more sensates. For example, the consumable may contain about 0.0001 wt % to about 5 wt % of one or more sensates, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is selected from vanilloids, sanshool, piperine, cinnamyl phenylpropyl compounds, ethyl esters, and combinations thereof, or an extract of at least one of ginger oil, black pepper, long pepper, prickly ash, chili powder, or Uzazi. Preferably, the warming or tingling agent comprises a vanilloid, such as 3-phenylpropyl homovanillate.

[0341] In some embodiments, one or more sensates as defined herein are present in the consumable in an amount of about 0.0001 wt% to about 3 wt%, such as about 0.0001 wt% to about 2.5 wt%, preferably about 0.0001 wt%-1 wt%, based on the total weight of the aerosolizable formulation.

[0342] In some embodiments, one or more sensates are present in the formulation in an amount of about 0.0001 wt% to about 5 wt%, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the formulation in an amount of about 0.0001 wt% to about 3 wt%, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the formulation in an amount of about 0.0001 wt% to about 2.5 wt%, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the formulation in an amount of about 0.0001 wt% to about 1 wt%, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin. In some embodiments, one or more sensates as defined herein are present in the formulation in an amount of about 0.0001 wt% to about 0.1 wt%, based on the total weight of the formulation, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent comprises a vanillin.

[0343] In some embodiments, the warming or tingling agent is present at a concentration of about 0.0001 wt% to about 0.005 wt% based on the total weight of the aerosolizable formulation. For the total amount of sensates, a concentration range of about 0.0001 wt% to about 0.005 wt% can be combined with any of the above concentrations. In some embodiments, one or more sensates consist of a warming or tingling agent, such that the "total" concentration of the one or more sensates is about 0.0001 wt% to about 5 wt%, preferably about 0.0001 wt% to about 3 wt%, with the wt% values being based on the total weight of the formulation. For each concentration range, the warming or tingling agent can be as defined above. For example, the warming or tingling agent can include vanillin. The absolute concentration of the sweetener is not critical to the present disclosure. In some embodiments, the weight ratio of sensate to sweetener is greater than about 1:1 to about 3:1, for example, greater than about 1:1 to about 2:1, preferably wherein the weight ratio of sensate to sweetener is about 2:1. When the sweetener is not neotame, the weight ratio can be adjusted according to the above expression (1) or (2). However, the sweetener can be present in an amount of about 0.0001wt% to about 5wt%, such as about 0.0001wt% to about 3wt%, preferably about 0.0001wt% to about 2.5wt%, more preferably about 0.0001wt% to about 1wt%. In a particularly preferred embodiment, based on the gross weight of the preparation, the sweetener can be present in an amount of about 0.0001wt%-0.1wt%. When the sweetener is not neotame, the concentration of the sweetener can be adjusted according to the above expression (3).

[0344] In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001 wt% to about 5 wt%, a sweetener in an amount of about 0.0001 wt% to about 5 wt%, and the humectant compound (iii) in an amount of greater than about 1 wt% to less than about 35 wt%, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001 wt% to about 5 wt%, the sensate, warming agent / tingling agent, sweetener, and humectant compound (iii) being defined according to the above embodiments, and the wt% values being based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0345] In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001 wt% to about 3 wt%, a sweetener in an amount of about 0.0001 wt% to about 3 wt%, and the humectant compound (iii) in an amount of greater than about 1 wt% to less than about 30 wt%, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001 wt% to about 3 wt%, the sensate, warming agent / tingling agent, sweetener, and humectant compound (iii) being defined according to the above embodiments, and the wt% values being based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0346] In some embodiments, the formulation comprises one or more sensates in an amount of about 0.0001 wt % to about 2.5 wt %, a sweetener in an amount of about 0.0001 wt % to about 2.5 wt %, and the humectant compound (iii) in an amount of greater than about 1 wt % to less than about 20 wt %, wherein at least one sensate is a warming agent or a tingling agent, and the warming agent or tingling agent is present at a concentration of about 0.0001 wt % to about 2.5 wt %, the sensate, warming agent / tingling agent, sweetener, and humectant compound (iii) being defined according to the above embodiments, and the wt % values being based on the total weight of the aerosolizable formulation. When the sweetener is not neotame, the sweetener concentration can be adjusted according to the above expression (3).

[0347] In any of the above embodiments, the warming or tingling agent may include vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener may be selected from compounds that bind to T1R2 and / or T1R3, sulfacetamide, sulfacetamide K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. Furthermore, the weight ratio of the sensate to the sweetener may be greater than about 1:1 to about 3:1 (optionally adjusted according to the above expression (1)).

[0348] In any of the above embodiments, at least one compound (iii) is selected from the group consisting of compounds of formula (II) and C3-C 18 In a preferred embodiment, at least one compound (iii) is selected from C4-C 18 Glycerides, C4-C 18 Hydrocarbon citrate and C3-C 16 Hydrocarbon diol. Based on the aerosolizable formulation, at least one compound (iii) is present in an amount of about 1 wt% to less than about 35 wt%. In some embodiments, based on the aerosolizable formulation, at least one compound (iii) is present in an amount of about 1 wt% to less than about 30 wt%.

[0349] In some embodiments, the aerosolizable formulations of the present disclosure include greater than about 5 wt% to less than about 20 wt% of triacetin. Triacetin is an organic compound with the formula shown in Appendix 1. It is classified as a triglyceride, a triester of glycerol, and is a common food additive, for example, as a solvent in condiments and for its moisturizing properties. It is available from various commercial sources.

[0350] Based on the total weight of the aerosolizable formulation, triacetin may be present in an amount of greater than about 8 wt % to less than about 20 wt %, such as greater than about 8 wt % to less than about 18 wt %, preferably greater than about 10 wt % to greater than about 18 wt %, and more preferably greater than about 10 wt % to less than about 14 wt %. In some embodiments, the formulation comprises about 0.001 wt % to about 1 wt % of one or more sensates, about 0.001 wt % to about 0.5 wt % of a sweetener, and greater than about 8 wt % to less than about 20 wt % of triacetin, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is present at a concentration of about 0.001 wt % to about 0.05 wt %, and the sensate, warming / tingling agent, and sweetener are defined according to the above embodiments.

[0351] In some embodiments, the formulation comprises from about 0.001 wt% to about 0.5 wt% of one or more sensates, from about 0.001 wt% to about 0.1 wt% of a sweetener, and from greater than about 8 wt% to less than about 18 wt% of triacetin, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is present at a concentration from about 0.001 wt% to about 0.05 wt%, and the sensates, warming / tingling agents, and sweeteners are defined according to the above embodiments.

[0352] In some embodiments, the formulation comprises from about 0.001 wt% to about 0.25 wt% of one or more sensates, from about 0.001 wt% to 0.05 wt% of a sweetener, and from greater than about 10 wt% to less than about 18 wt% of triacetin, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is present at a concentration of from about 0.001 wt% to about 0.05 wt%, and the sensates, warming / tingling agents, and sweeteners are defined according to the above embodiments.

[0353] In some embodiments, the formulation comprises about 0.001 wt% to about 0.1 wt% of one or more sensates, about 0.001 wt%-0.025 wt% of a sweetener, and greater than about 10 wt% to less than about 14 wt% of triacetin, wherein at least one sensate is a warming or tingling agent, and the warming or tingling agent is present at a concentration of about 0.001 wt% to about 0.005 wt%, and the sensates, warming / tingling agents, and sweeteners are defined according to the above embodiments.

[0354] In any of the above embodiments, the warming or tingling agent may include vanillin (e.g., 3-phenylpropyl homovanillate), and the sweetener may be selected from compounds that bind to T1R2 and / or T1R3, sulfacetamide, sulfacetamide K, aspartame, neotame, sodium cyclamate, stevia, saccharin, sucralose, gluconic acid, and mixtures thereof. Furthermore, the weight ratio of the sensate to the sweetener may be greater than about 1:1 to about 3:1 (optionally adjusted according to the above expression (1)).

[0355] The present inventors have found that the amounts of sensates, sweeteners and humectants (such as triacetin) as described above can provide a beneficial effect of changing or improving at least one organoleptic property of the aerosolizable formulation. The organoleptic property can be selected from taste, mouthfeel, smoking experience or a combination thereof to replicate smoking while ensuring consumer safety.

[0356] Products, aerosol delivery systems and containers

[0357] In another aspect, an article comprising an aerosolizable formulation as defined herein is provided. The article may be a container, such as a bottle, or may be a component for use with an aerosol supply device. For example, the article may include an area for receiving the aerosolizable formulation as defined herein (storage element), an aerosol generating component, an aerosol generating region, and an optional mouthpiece.

[0358] In some embodiments, an article for use with an aerosol supply system is provided, the article comprising a store containing an aerosolizable formulation as described herein, an aerosol generating component (such as a heater), an aerosol generating region, a delivery element, and a mouthpiece.

[0359] The aerosolizable material (aerosolizable formulation) can be transferred from a storage element for receiving the aerosolizable material to the aerosol generating component via a transfer element (e.g., a wick, a pump, etc.). A person skilled in the art will be able to select a suitable transfer element based on the type of aerosolizable material to be transferred and the rate at which it must be delivered. Particularly noteworthy are transfer elements formed from fiber materials, foam materials, sintered materials, woven materials, and nonwoven materials, such as wicks.

[0360] The airflow path typically extends through the article (optionally via the device) to the outlet. The path is oriented so that the generated aerosol is entrained in the airflow, thereby enabling it to be delivered to the outlet for inhalation by the user.

[0361] In some embodiments, the aerosol generating component is a heater.

[0362] Typically, the area for receiving aerosolizable material will allow the article to be refilled with the aerosolizable material as it becomes depleted during use.

[0363] In another aspect, there is provided an aerosol supply system comprising an aerosol supply device and an article as defined herein.The aerosol supply system is preferably non-combustible. The non-flammable aerosol supply system is Systems that release compounds from aerosol-generating materials without burning the aerosol-generating materials, such as electronic cigarettes, tobacco heating products, and hybrid systems that use a combination of aerosol-generating materials to generate aerosols. According to the present disclosure, a "non-combustible" aerosol supply system refers to a system in which the constituent aerosol-generating materials of the aerosol supply system (or its components) do not burn or ignite to assist in delivering at least one substance to a user. The system can heat the aerosol-generating material / system or aerosolizable formulation or a consumable of the system / formulation to a temperature of at least about 200°C, preferably at least about 250°C. In some embodiments, the aerosol supply system generates an aerosol by heating to a temperature of about 250 to about 400°C.

[0364] The aerosol supply system may also be referred to herein as an aerosol delivery system. In some embodiments, the delivery system is a non-combustible aerosol supply system, such as an electrically powered non-combustible aerosol supply system. In some embodiments, the non-combustible aerosol supply system is an electronic cigarette, also known as an electronic cigarette device or an electronic nicotine delivery system (END), but it is worth noting that the presence of nicotine in the aerosol-generating material is not required.

[0365] In some embodiments, the non-combustible aerosol supply system is an aerosol-generating material heating system, also known as a heat-not-burn system. An example of such a system is a tobacco heating system.

[0366] In some embodiments, the non-combustible aerosol delivery system is a hybrid system that generates an aerosol using a combination of aerosol-generating materials, one or more of which can be heated. Each aerosol-generating material can be in the form of, for example, a solid, liquid, or gel, and can contain or not contain nicotine. In some embodiments, the hybrid system comprises a liquid or gel aerosol-generating material and a solid aerosol-generating material. The solid aerosol-generating material can include, for example, tobacco or non-tobacco products.

[0367] Generally speaking, the non-combustible aerosol supply system may include a non-combustible aerosol supply device and consumables for use with the non-combustible aerosol supply device. The consumables are as defined herein.

[0368] In some embodiments, the non-combustible aerosol supply system, such as a non-combustible aerosol supply device thereof, can include an energy source and a controller. For example, the energy source can be an electrical source or an exothermic energy source. In some embodiments, the exothermic energy source comprises a carbon substrate that can be electrically powered to distribute power in the form of heat to the aerosol-generating material or a heat transfer material near the exothermic energy source.

[0369] Figure 1 is a highly schematic illustration (not to scale) of an exemplary aerosol delivery system, such as an electronic cigarette 10, to which various embodiments are applicable, but not limited thereto. The electronic cigarette has a generally cylindrical shape extending along a longitudinal axis indicated by a dashed line (although aspects of the present invention are applicable to electronic cigarettes constructed in other shapes and arrangements), and includes two main components, namely, an aerosol delivery device 20 and an article 30.

[0370] The article 30 includes a storage element for an aerosolizable material (source liquid) 38, the storage element containing the aerosolizable material from which an aerosol is generated. The article 30 also includes an aerosol generating component (heating element or heater) 36 for heating the aerosolizable material to generate an aerosol. A transfer element or wicking element or wick 37 is provided to deliver the aerosolizable material from the storage element 38 to the heating element 36. One or more portions of the wick 37 are in fluid communication with the aerosolizable material in the storage element 38, and the aerosolizable material is drawn along or through the wick 37 to one or more portions of the wick 37 in contact with the heater 36 by wicking or capillary action.

[0371] By applying thermal energy to the aerosolizable material, vaporization occurs, and the aerosolizable material vaporizes at the interface between the wick 37 and the heater 36, thereby generating an aerosol. The aerosolizable material, the wick 37, and the heater 36 may be collectively referred to as an aerosol or vapor source. The wick 37 and the heater 36 may be collectively referred to as a vaporizer or atomizer 15.

[0372] Typically there is one wick, but it is envisaged that there may be multiple wicks, for example, two, three, four or five wicks.

[0373] As described above, the wick may be formed from a sintered material. The sintered material may include sintered ceramic, sintered metal fibers / powder, or a combination of both. The sintered wick (or at least one / all) may have a resistive heater deposited thereon / embedded therein. Such a heater may be formed from a thermally conductive alloy such as a NiCr alloy. Alternatively, the sintered material may have electrical properties such that it is heated when an electric current is passed through it. Thus, the aerosol generating assembly and the wick may be considered to be integrated. In some embodiments, the aerosol generating assembly and the wick are formed from the same material and form a single assembly.

[0374] In some embodiments, the wick is formed from a sintered metal material, typically in the form of a planar sheet. Thus, the wick element can have a substantially thin, flat shape. For example, it can be considered a sheet, layer, film, substrate, etc. This means that the thickness of the wick is less than or significantly less than at least one of its length and width. Thus, the wick thickness (its smallest dimension) is less than or significantly less than its longest dimension.

[0375] The wick may be made of a uniform, granular, fibrous or flocculent sintered metal to form a capillary structure. The wick element may be made of a conductive material that is a non-woven sintered porous mesh structure comprising metal fibers such as stainless steel fibers. For example, the stainless steel may be AISI (American Iron and Steel Institute) 316L (corresponding to European Standard 1.4404). The weight of the material may be between 100 and 300 g / m². 2 within the range.

[0376] Where the wick is generally planar, the thickness of the wick may be in the range of 75-250 μm. A typical fiber diameter is about 12 μm, while a typical average pore size (the size of the spaces between the fibers) is about 32 μm. An example of this type of material is Bekipor (RTM) ST porous metal fiber media manufactured by NV Bekaert SA of Belgium, a series of porous nonwoven fiber matrix materials made by sintering stainless steel fibers.

[0377] Also note that while the material is described as planar, this refers to the relative dimensions of the sheet material and the wick (thickness being many times smaller than length and / or width), and does not necessarily indicate flatness, particularly the flatness of the final wick made from the material. A wick may be flat, but may alternatively be formed from the sheet material into a non-planar shape, such as curved, corrugated, corrugated, ridged, tubular, or otherwise made concave and / or convex.

[0378] The wick element can have a variety of properties. It is formed of a porous material so that the desired wicking or capillary effect can be achieved to draw the source liquid from the storage element of aerosolizable material (where the wick meets the aerosolizable material at the storage element contact location) to the vaporization interface. The porosity is typically provided by a plurality of interconnected or partially interconnected channels (holes or gaps) running through the material and open to the outer surface of the material. Depending on the material, the channel size and the desired wicking rate, any level of porosity can be used. For example, a porosity of 30%-85% can be selected, such as 40%-70%, 50%-80%, 35%-75% or 40%-75%. This may be an average porosity value for the entire wick element, as the porosity may or may not be uniform across the core. For example, the pore size at the storage element contact location may be different from the pore size near the heater.

[0379] It is useful for the wick to have sufficient rigidity to be self-supporting within the article. For example, it may be mounted at or near one or both edges and needs to substantially maintain its position without bending, flexing, or sagging. For example, porous sintered ceramic is a useful material for the wick element. Any ceramic with a suitable porosity can be used. If a porous ceramic is chosen as the porous wick material, it can be obtained as a powder that can be formed into a solid by sintering (heating to cause agglomeration, possibly under applied pressure). Sintering then solidifies the ceramic to form the porous wick.

[0380] The article 30 also includes a mouthpiece 35 having an opening through which a user can inhale the aerosol generated by the vaporizer 15. The aerosol for inhalation can be described as an aerosol stream or an inhalable gas stream.

[0381] The aerosol delivery device 20 includes a power source (rechargeable battery or battery 14, hereinafter referred to as a battery) for providing power to the electronic cigarette 10, and a controller (printed circuit board (PCB)) 28 and / or other electronic devices for generally controlling the electronic cigarette 10. Therefore, the aerosol delivery device can also be considered as a battery portion, a control unit, or a portion.

[0382] During operation of the device, the controller will determine that the user has initiated a request to generate an aerosol. This can be achieved by a button on the device, which signals the controller that the aerosol generator should be powered on. Alternatively, a sensor located in or near the airflow path can detect the airflow through the airflow path and transmit this detection result to the controller. In addition to the presence of a button, a sensor can also be present because it can be used to determine certain usage characteristics, such as airflow, the timing of aerosol generation, etc.

[0383] For example, in use, when the heater 36 receives power from the battery 14, as may be controlled by the circuit board 28 in response to pressure changes detected by an air pressure sensor (not shown), the heater 36 vaporizes the aerosolizable material delivered by the wick 37 to generate an aerosol, and the aerosol stream is then inhaled by the user through the opening in the mouthpiece 35. As the user inhales on the mouthpiece, the aerosol is drawn from the aerosol source along the air passage ( ) connecting the aerosol source to the mouthpiece opening. Figure 1 (not shown) is transferred to the suction nozzle 35.

[0384] In this embodiment, the device 20 and the article 30 can be detached from each other by separating in a direction parallel to the longitudinal axis, such as Figure 1 1 , but when the system 10 is in use they are connected together by cooperating engagement elements 21, 31 (e.g., screw, magnetic or bayonet fittings) to provide a mechanical and electrical connection between the device 20 and the article 30, and in particular to connect the heater 36 to the battery 14. As known to those skilled in the art, the battery can be recharged.

[0385] In some embodiments, the article comprises / forms a sealed container. For example, the sealed container can be hermetically sealed. The hermetically sealed container can include a blister pack having one or more hermetically sealed compartments for storing one or more articles comprising an aerosolizable formulation as described herein.

[0386] In some embodiments, the article includes a shell, and the aerosolizable formulation is contained in the shell. The shell can be transparent so that the aerosolizable formulation can be observed from the outside of the shell. It is also possible that the shell has a certain degree of opacity so that light is restricted from passing through the shell. This may be important so as to prevent light (such as ultraviolet light) from entering the shell and damaging the stability of the aerosolizable material. In some embodiments, the shell is formed by a material that suppresses / prevents ultraviolet light from passing through. In some embodiments, the above-mentioned sealed container can be formed by a material with opacity, thereby limiting the passage of light through the sealed container. In addition, the above-mentioned sealed container can be formed by a material that suppresses / prevents ultraviolet light from passing through. This can also be a case where the sealed container is hermetically sealed and / or includes a blister package having one or more sealed compartments for storing one or more articles comprising the aerosolizable material described herein.

[0387] Methods and uses

[0388] In some embodiments described herein, a method of forming an aerosol is provided, the method comprising providing an aerosolizable formulation as defined herein and aerosolizing the formulation. The method may alternatively comprise providing an aerosol generating system as described herein or an aerosol supply system as defined herein, and aerosolizing the formulation or consumable in the system.

[0389] According to some embodiments, there is provided the use of about 0.0001 wt % to about 5 wt % of one or more sensates in an aerosolizable formulation in combination with a sweetener and a compound that acts as a humectant to modify at least one sensory characteristic of the formulation, wherein at least one sensate is a warming agent or a tingling agent, wherein the compound has a boiling point of at least 200° C. at atmospheric pressure. The aerosolizable formulation is characterized by any of the characteristics defined and discussed herein. The humectant function and boiling point of the compound correspond to the humectant function and boiling point of “compound (iii)” of the consumable described above. However, this use is not necessarily limited to the esters, diols, or polyols defined above.

[0390] According to other embodiments, about 0.0001 wt % to about 5 wt % of one or more sensates are provided in an aerosolizable formulation with a sweetener and a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 Use of a combination of hydrocarbon polyol compounds to modify at least one sensory property of a formulation, wherein at least one sensory agent is a warming or tingling agent, wherein the polyol comprises three or more hydroxyl groups. The aerosolizable formulation is characterized by any of the characteristics defined and discussed herein. The moisturizing function and chemical properties of the compound correspond to "compound (iii)" of the consumable described above. However, this use is not necessarily limited to a boiling point of at least about 200°C as defined above.

[0391] According to some embodiments described herein, there is provided the use of about 0.0001 wt % to about 1 wt % of one or more sensates in an aerosolizable formulation in combination with a sweetener and triacetin to improve at least one sensory characteristic of the formulation, wherein the at least one sensate is a warming agent or a tingling agent. The aerosolizable formulation is characterized by any of the characteristics defined and discussed herein.

[0392] In some embodiments, the use comprises altering or improving at least one organoleptic property selected from taste, mouthfeel, smoking experience, and combinations thereof. The mouthfeel and / or smoking experience can include a sense of fullness, aftertaste, punch, and nicotine throat hit to replicate smoking. The alteration or improvement can be relative to an aerosolizable formulation that does not employ a combination of one or more sensates, sweeteners, and humectant compounds (e.g., triacetin), wherein at least one sensate is a warming agent or a tingling agent.

[0393] In some embodiments, the use includes changing or improving the taste of the preparation to replicate smoking. In some embodiments, the use includes changing or improving the mouthfeel of the preparation to replicate smoking. In some embodiments, the use includes changing or improving the saturation to replicate smoking. In some embodiments, the use includes changing or improving the aftertaste to replicate smoking. In some embodiments, the use includes changing or improving the nicotine throat hit to replicate smoking. In some embodiments, the use includes modifying or improving the impact to replicate smoking. In some embodiments, the use includes modifying or improving the smoking experience to replicate smoking. In some embodiments, the use includes improving the nicotine sensation to replicate smoking.

[0394] According to some embodiments, there is provided a use of a humectant for modifying the mouthfeel of an aerosolizable formulation or an aerosol generating system, the humectant having a boiling point of at least 200° C. at atmospheric pressure, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product (preferably a cigarette). The aerosolizable formulation or aerosol generating system is characterized by any of the features defined and discussed herein. The moisturizing function and boiling point of the compound correspond to "compound (iii)" of the consumable discussed above. However, this use is not necessarily limited to esters, diols, and polyols as defined herein.

[0395] According to some embodiments, there is provided a use of a humectant for modifying the mouthfeel of an aerosolizable formulation or an aerosol generating system, wherein the humectant is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette. The aerosolizable formulation or aerosol generating system is characterized by any of the features defined and discussed herein. The moisturizing function and chemical properties of the compound correspond to "compound (iii)" of the consumable described above. However, the use is not necessarily limited to a boiling point of at least about 200° C. as defined above.

[0396] These sensory properties are defined herein and measured by a trained sensory panel. A trained sensory panel is a team of trained evaluators who define the sensory attributes (e.g., taste, mouthfeel, and / or smoking experience) that best describe the product being evaluated. The trained sensory panel is composed of smokers and / or dualists (i.e., users of both cigarettes and e-cigarettes).

[0397] According to some embodiments, there is provided a use of about 0.0001 wt % to about 5 wt % of a warming or tingling agent in combination with a sweetener and a humectant in a tobacco-flavored aerosolizable formulation or an aerosol-generating system to alter the tobacco flavor intensity of a consumable product in the formulation or system, wherein the humectant compound has a boiling point of at least 200° C. at atmospheric pressure and / or is a C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups. In each of these uses, the aerosolizable formulation or aerosol generating system may be characterized as defined herein.

[0398] According to some embodiments, there is provided a use of about 0.0001 to about 0.05 wt% of a warming agent or tingling agent in a tobacco flavor aerosolizable formulation in combination with a sweetener and triacetin to modify the tobacco flavor intensity thereof. According to some embodiments, there is provided a use of about 0.0001 to about 1 wt% of one or more sensates in a tobacco flavor aerosolizable formulation in combination with a sweetener and triacetin to modify the tobacco flavor intensity thereof, wherein at least one sensate is a warming agent or tingling agent. In each of these uses, the aerosolizable formulation may be characterized by the features defined herein.

[0399] The invention will now be described with reference to the following non-limiting examples.

[0400] Example

[0401] An investigation was conducted to address the sensory gap between using an aerosol delivery device (i.e., an e-cigarette product) and smoking a conventional cigarette. A baseline aerosolizable formulation was used for comparison, chosen because of its popularity among smokers in the UK market.

[0402] The sensory focus areas are: flavor, aerosol body / mouthfeel, and smoking experience, including sensory fullness, aftertaste, and / or nicotine “throat hit.” These areas represent consumer-specified differences between aerosol delivery devices and traditional cigarettes.

[0403] The survey addressed the use of sweeteners, flavorings, cooling agents (such as WS-23), warming / tingling agents, natural oils, menthol, increased water levels, and reduced acid levels.

[0404] The materials used to prepare the aerosolizable formulation are shown in Table 1 below.

[0405] Table 1: Materials used for aerosolizable formulations

[0406]

[0407] Experiment 1

[0408] Consumables containing the compounds described in Table 1 were prepared in ethanol. Specifically, stock solutions of each compound were prepared in ethanol. For the final formulation, specific aliquots of each stock solution were combined and brought to a specified volume to achieve the target concentration. Various formulations were prepared as shown in Table 2.

[0409] Subsequently, a sensory analysis was conducted by a trained sensory panel of 10 smokers and / or dual users. This panel was selected for their expertise and knowledge of the design and sensory properties of traditional cigarettes. Samples of each formulation were prepared according to the details in Table 2, and the panelists compared the sensory experience of each formulation in an aerosol delivery device relative to tobacco-flavored e-liquid. Table 2 summarizes the feedback from the trained sensory panel. Weight % values are relative to the total weight of the formulation.

[0410] Table 2

[0411]

[0412]

[0413]

[0414] ————————————

[0415] 1 FMC = factory-made cigarettes

[0416] Comparing Examples 1a, 1b, 2a, 2b, and 4 shows how a single compound does not change a single sensory factor. In contrast, when triacetin and Symheat were each independently added to tobacco-flavored e-liquids, multifactorial changes were observed. Unexpectedly, triacetin was found to change mouthfeel and aerosol body, but did not have the desired effect or irritation. Unexpectedly, Symheat (3-phenylpropyl homovanillate) was found to change the impact, but unexpectedly increased the roughness and irritation of the aerosol. Symheat is also reported to change the location of the impact sensation.

[0417] The combination of Symheat and triacetin (Comparative Example 3) is advantageous in some respects because it improves oral coating, mouthfeel, and residue. However, this combination is problematic for users due to the irritation and impact. Panelists reported additional irritation that was "tingling" and left an unpleasant "pepper" sensation on the tongue. The combination of neotame and Symheat (Comparative Example 5) made the irritation produced by Symheat alone more palatable, but the e-liquid left a residual taste.

[0418] Comparative Example 6 investigated the addition of water to tobacco flavored e-liquid, but this resulted in lower flavor intensity and mouthfeel.

[0419] In Examples 7, 8, 9, and 10, only the triple combination of triacetin, Symheat, and neotame resulted in panelists reporting an "FMC-like" experience. This triple combination is also noteworthy because it reported increased body, mouthfeel, and mouthfullness, while the nicotine sensation remained, providing the desired aftertaste. Examples 7, 8, 9, and 10 also included the same higher impact and stimulating feedback as smoking.

[0420] Experiment 2

[0421] Aerosolizable formulations containing the compounds in Table 1 were prepared in ethanol in the same manner as in Experiment 1. Specifically, a stock solution of each compound was prepared in ethanol. For the final formulation, specific aliquots of each stock solution were combined and brought to a specified volume to achieve the target concentration. Various formulations were prepared as shown in Table 3. Tobacco Flavor 1 and Tobacco Flavor 2 are e-cigarette liquids commercially available from Nicoventures Retail (UK) Limited. The wt% values are relative to the total weight of the formulation.

[0422] Table 3

[0423]

[0424] Sensory analysis was performed by a trained sensory panel consisting of 10 smokers and / or dual users (ie, consumers of cigarettes and aerosol delivery devices).

[0425] Panelists individually compared the sensory experience of each formulation in a VuseGo device supplied by Nicoveventures Retail (UK) Limited with each tobacco-flavored e-liquid. This e-liquid was selected as the benchmark due to consumer preferences in the UK market. Panelists' comments are summarized in Table 4.

[0426] Table 4

[0427]

[0428] When added to Tobacco Flavor 1, Examples 11, 13, and 15 reported varying levels of tobacco flavor intensity. Example 11 was described as having a "similar sensation during puff to FMC," with increased impact and a low "head buzz," while Example 13 provided a "medium intensity" and Example 15 had a "light tobacco flavor." This varying intensity is advantageous because it allows the formulation to be manipulated according to the desired level of sensation, a quality that e-cigarette product users increasingly desire to customize and control.

[0429] When added to Tobacco Flavor 2, Examples 12, 14, and 16 similarly resulted in varying tobacco flavor intensities. Example 12 had a "near Virginia blend cigarette flavor," while Example 14 was "very aromatic" with a "mild cigarette flavor," and Example 16 had a "complex flavor" mixed with a "cigarette flavor without the smoky or burnt notes." As with Tobacco Flavor 1, this is advantageous because it provides flexibility to formulators and choice to consumers.

[0430] Experiment 3

[0431] To explore the effects of varying levels of warming / tingling agents compared to Example 1, the aerosolizable formulations described in Table 5 below were prepared and subjected to product developer testing (PDT) (sensory testing) of e-liquids. All concentrations are in wt% based on the total weight of the formulation.

[0432] This preparation was prepared using the same method as in Experiment 2 above.

[0433] PDT was performed using a sequential monadic scale (1-10) to evaluate the sensory properties of the formulations in Table 5 compared to a similar FMC experience. Specifically, the purpose was to determine the effect of warming / tingling agent inclusion on throat hit and irritation.

[0434] Ten participants were asked to rate throat hit and pungency, and / or the overall true throat hit of the product offered relative to the FMC experience. Participants were also asked if there was a burnt taste or unpleasant aftertaste.

[0435] All samples used the same aerosol delivery device. This was a non-flammable aerosol delivery device. All participants were given the same instructions. The only difference between each test was the formulation used in the non-flammable aerosol delivery device. These formulations differed in the concentration of a warming / tingling agent, such as Symheat (CAS No. 105025-99-8). The control formulation included 0.01 wt% Symheat, while the other test formulations included 2x, 5x, or 10x Symheat.

[0436] Table 5

[0437]

[0438] Based on the data, we concluded that a range of concentrations of warming / tingling agents could be used to deliver the desired "FMC-like" experience, particularly throat hit and stimulation.

[0439] Experiment 4

[0440] To investigate the use of consumables in gel-like aerosolizable formulations, the gels detailed in Table 6 below were prepared, formed into sticks, and subjected to a Product Developer's Test (PDT) in a non-flammable aerosol delivery system for sensory evaluation. All concentrations are in wt% based on the total weight of the formulation.

[0441] In order to prepare this preparation, glycerine and adhesive are placed in the blender and premixed, filler is converged to form slurry respectively.Then tobacco extract and triacetin (if present) are slowly added in the slurry, then premixed glycerine and adhesive.The mixture of said convergence is blended, and then neotame and Symheat solution are joined in the final slurry (if present).Said preparation is cast on metal plate and is dried and forms gelatinous sheet.

[0442] PDT was conducted using an ordinal unary scale (1-7) to evaluate the sensory performance of the formulations in Table 6 compared to a similar FMC experience. In doing so, five participants were asked to evaluate the level of heat intake, immediate smoke satisfaction, flavor level, aerosol consistency, overall flavor amplitude, puff strength, aerosol body, visible aerosol, irritation level, and punch level of the products provided. These five participants were regular smokers.

[0443] Each formulation was administered using the same apparatus. The apparatus was a non-flammable aerosol delivery system. All participants were given the same instructions. The only difference between the tests was the formulation being tested, which differed in that consumables according to the present disclosure (and a corresponding balance of fillers) were included, as shown in Table 6. Formulation 2 included 0.01 wt% neotame and 0.01 wt% Symheat, based on the total weight of the formulation.

[0444] Table 6

[0445] Preparation 1 Preparation 2 Filler (wood pulp) 6.00 6.00 Adhesives 4.00 4.00 Tobacco extract 45.00 45.00 Aerosol former material (glycerin) 20.00 20.00 Filler (cellulose) 25.00 23.90 triacetin 0.00 10.00 Neotame (10wt% solution) 0.00 0.10 Symheat (1 wt% solution) 0.00 1.00

[0446] The results are as follows Figure 2 and Figure 3 As shown. Figure 2 In , Formula 1 is the inner graph and Formula 2 is the outer graph. Figure 3 In the figure, formulation 1 is the lower figure, and formulation 2 is the upper figure.

[0447] according to Figure 2 It can be seen how the addition of the consumable product according to the present disclosure alters the sensory experience of the aerosolizable formulation, bringing it closer to the FMC experience. Specifically, Formulation 2 received higher ratings for immediate smoke sensation, aerosol consistency, overall flavor amplitude, aerosol body, visible aerosol, irritation level, and punch level. Changing irritation, punch, and aerosol body is important and highly beneficial in replicating the FMC experience.

[0448] Figure 3 Shows the Figure 2 The same results, but using absolute values. It can also be seen that Formulation 2 received higher ratings in terms of immediate smoke sensation, aerosol consistency, overall flavor amplitude, aerosol body, visible aerosol, irritation level, and punch level. Notably, the punch level increased from 5.8 to 7, the irritation level increased from 5.2 to 7, and the aerosol body increased from 5 to 5.8. These factors are particularly beneficial when attempting to replicate the smoking of combustible tobacco products such as cigarettes.

[0449] Experiment 5

[0450] Based on the results of Experiments 1-4, alternative humectant compounds were evaluated in the aerosolizable formulations described in Table 7. These formulations were compared with formulations containing triacetin and subjected to product developer testing (PDT) (sensory testing) of e-cigarette liquids to determine whether the consumables replicated one or more sensations of smoking a traditional cigarette.

[0451] This formulation was prepared using the same method as in Experiment 2. Tobacco Flavor 3 is an e-cigarette liquid commercially available from Nicoventures Retail (UK) Limited. All wt% values are relative to the total weight of the formulation.

[0452] All samples were administered using the same apparatus, a non-flammable aerosol delivery system. All participants were given the same instructions. The only difference between the tests was the formulation tested, which varied in terms of the humectant compound and / or its concentration.

[0453] Formulation A is the baseline formulation; it includes 10 wt% of triacetin as the humectant compound.

[0454] Formulation B included 1 wt% of triethyl citrate (TEC) as the humectant compound.

[0455] Formulation C included 5 wt% of triethyl citrate as the humectant compound.

[0456] Formulation D included 10 wt% of triethyl citrate as the humectant compound.

[0457] Formulation E included 5 wt% of 1,3-propylene glycol as the humectant compound.

[0458] Table 7

[0459]

[0460]

[0461] PDT was performed using an ordinal unary scale (1-7) to evaluate the sensory properties of the formulations in Table 7. The PDT panelists in this study were either smokers or dual users. Panelists were asked to rate each sample individually based on the attributes listed below on a scale of 1-7, followed by an open-ended question about mouthfeel. Panelists were then asked to compare the samples and rate them in order of most FMC.

[0462] Attributes: First puff satisfaction; mouth fullness of vapor; punch; pungency; flavor intensity; mouth coating; mouth dryness; nicotine throat hit; and visible vapor.

[0463] The results of the attribute ratings were averaged, e.g. Figure 4 and Figure 5 As shown. The following conclusions can be drawn:

[0464] - The 10% TEC (D) and 5% 1,3-propylene glycol (E) samples were rated closest to the benchmark (A) for mouth residue and dry mouth.

[0465] 1,3-Propanediol scored highest for both mouthfullness and visible vapor (E), but overall, all samples received similar ratings.

[0466] - First-puff satisfaction scores were similar across all samples, with the highest scores for 1,3-propylene glycol (E).

[0467] Irritation ratings did not vary with the level of TEC in the formulation. One potential reason for this is that ymheat is known to cause irritation during use. Therefore, if there is residual irritation from the previous sample, this may affect the scores of subsequent samples. The fact that the 5% TEC sample (C) was the first to be tested and received the lowest score indirectly suggests this may be the case.

[0468] The open-ended questions and their responses are shown in Table 8. The ranking of “most similar to FMC” is shown in Table 9.

[0469] Table 8

[0470]

[0471] Table 9

[0472]

[0473] There was no clear trend between samples that indicated a similar FMC experience. 10% TEC was rated closest to an FMC-like experience by the majority of panelists, but an equal number also rated it as being the most different from an FMC-like experience. Most panelists ranked 1% TEC in the top three, while most ranked the 10% triacetin benchmark second.

[0474] Therefore, the subtle differences between BE and A support the use of these alternative compounds instead of triacetin.

[0475] Overall, these data support the advantages of the humectant compounds described herein. Specifically, these data support the use of humectants to modify the mouthfeel of an aerosolizable formulation or an aerosol-generating system, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product. These data also support the use of humectant compounds in combination with warming / tingling agents and sweeteners to modify the tobacco flavor intensity of the formulation and / or at least one organoleptic characteristic of the aerosolizable formulations described herein.

[0476] The present invention is described in further detail in the following numbered embodiments.

[0477] 1. A consumable product for an aerosolizable formulation, wherein the consumable product comprises:

[0478] (i) one or more sensates, wherein at least one sensate is a warming or tingling agent;

[0479] (ii) sweeteners; and

[0480] (iii) triacetin, optionally wherein the weight ratio of sensate to sweetener is from greater than about 1:1 to about 3:1.

[0481] 2. The consumable according to claim 1, wherein the sweetener is selected from the group consisting of oxadiazine sweeteners, aspartame sweeteners, sulfamate, calcium cyclamate, sugar alcohols, natural sweeteners, saccharin, sucralose, gluconic acid, and mixtures thereof.

[0482] 3. A consumable according to clause 1 or clause 2, wherein the sweetener comprises at least one selected from the group consisting of aspartame sweetener, stevioside, monk fruit extract, glycyrrhizin, perilla frutescens, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, raspberry extract, rebaudioside A, saccharin, sucralose and sodium cyclamate, preferably wherein the sweetener comprises at least one selected from the group consisting of acesulfame-K, aspartame, neotame, saccharin, sucralose or sodium cyclamate, preferably wherein the sweetener is neotame or aspartame.

[0483] 4. The consumable according to any one of clauses 1 to 3, wherein the weight ratio of sensate to sweetener is greater than about 1:1 to about 2:1, preferably wherein the weight ratio is about 2:1.

[0484] 5. A consumable according to any one of clauses 1 to 4, wherein the one or more sensate further comprises a cooling agent, preferably wherein the cooling agent is selected from menthol, N,2,3-trimethyl-2-propan-2-ylbutanamide, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[(5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, N-(4-methoxyphenyl)-menthylcarboxamide, N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, 3-(menthoxy)propane-1,2-diol and menthyl succinate.

[0485] 6. A consumable according to any one of clauses 1 to 5, wherein the warming agent or the tingling agent is selected from the group consisting of vanilloids, sanshool, piperine, allyl isothiocyanate, cinnamyl phenylpropyl compounds, ethyl esters and combinations thereof.

[0486] 7. A consumable according to clause 6, wherein the warming or tingling agent is a vanillin, preferably 3-phenylpropyl homovanillate.

[0487] 8. The consumable according to any one of clauses 1 to 7, wherein the consumable further comprises one or more selected from 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furylthiol, trigonelline, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone, β-damascenone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylvaleric acid, butyric acid , β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, safranal, maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione (coronol), mesifurane, maple furanone, benzaldehyde, 4-propyl-2-methoxyphenol, 4-allyl-2,6-dimethoxyphenol, 3-methyl-2,4-nonanedione, 5,6,7-trimethylocta-2,5-dien-4-one or a combination thereof.

[0488] 9. The consumable according to clause 8, wherein at least one compound is selected from the group consisting of compounds A, B, C, D, E and combinations thereof,

[0489] wherein A is at least one compound selected from acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylpentanoic acid and butyric acid, preferably A is at least one compound selected from acetic acid, 3-methylbutyric acid, 3-methylpentanoic acid;

[0490] B is at least one compound selected from β-damascenone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral and safranal, preferably B is at least another compound selected from β-damascenone, β-damascenone and β-ionone;

[0491] C is at least one compound selected from maltol, ethyl maltol and trigonelline lactone, preferably C is at least one compound selected from maltol and trigonelline lactone;

[0492] D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione, homomethylfuran, maple furanone, 4-propyl-2-methoxyphenol, benzaldehyde and 4-allyl-2,6-dimethoxyphenol, preferably D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-methoxyphenol and phenylacetic acid; and

[0493] E is at least one compound selected from 3-methyl-2,4-nonanedione and 5,6,7-trimethylocta-2,5-dien-4-one, and preferably E is 3-methyl-2,4-nonanedione.

[0494] 10. An aerosolizable formulation for use in an aerosol delivery system comprising a consumable according to any one of clauses 1 to 9, a carrier and optionally nicotine.

[0495] 11. An aerosolizable formulation for an aerosol supply system comprising a consumable according to any one of clauses 1 to 10, wherein the formulation comprises from about 0.001 wt% to about 1 wt% of one or more sensates and from greater than about 5 wt% to less than about 20 wt% of triacetin.

[0496] 12. An aerosolizable formulation according to clause 12, wherein the formulation comprises a carrier and optionally an active agent, preferably wherein the active agent is nicotine.

[0497] 13. An aerosolizable formulation according to any one of clauses 11 to 13, wherein the carrier is present in an amount of 50 wt% or more based on the total weight of the formulation, preferably wherein the carrier is present in an amount of 70 wt% or more based on the total weight of the formulation, preferably wherein the carrier comprises propylene glycol and / or glycerol.

[0498] 14. An aerosolizable formulation according to any one of clauses 11 to 13, wherein the triacetin is present in a concentration of greater than about 10 wt% up to about 18 wt%, preferably greater than about 10 wt% to about 14 wt%.

[0499] 15. An aerosolizable formulation according to any one of clauses 11 to 14, wherein the one or more sensate agents are present in a concentration of about 0.001 wt% to about 0.5 wt%, about 0.001 wt% to about 0.1 wt%, or about 0.001 wt%-0.05 wt%.

[0500] 16. An aerosolizable formulation according to clause 16, wherein the warming or tingling agent is present in a concentration of about 0.001 wt% to about 0.005 wt%, preferably about 0.001 wt% to about 0.0025 wt%.

[0501] 17. An article comprising the aerosolizable formulation of any one of clauses 11 to 16.

[0502] 18. An article according to clause 17, comprising a storage element for receiving the aerosolizable formulation according to any one of clauses 11 to 16, an aerosol generating component, an aerosol generating region, a delivery element and an optional mouthpiece, preferably wherein the aerosol generating component comprises a heater and / or wherein the delivery element is a wick.

[0503] 19. An aerosol supply system comprising an aerosol supply device and an article according to clause 18.

[0504] 20. A method of forming an aerosol, the method comprising providing an aerosolizable formulation according to any one of clauses 11 to 16, and aerosolizing the formulation.

[0505] 21. A sealed container comprising an article according to clause 18, optionally wherein the container is hermetically sealed and formed from a material that inhibits or prevents the passage of ultraviolet light.

[0506] 22. Use of about 0.001 wt% to about 1 wt% of one or more sensates in combination with a sweetener and triacetin to improve at least one organoleptic property of an aerosolizable formulation, wherein at least one sensate is a warming or tingling agent, preferably wherein the aerosolizable formulation is characterized according to any one of clauses 1 to 16.

[0507] 23. The use according to clause 22, wherein the organoleptic properties are selected from taste, mouthfeel and smoking experience, and the organoleptic properties are improved relative to an aerosolizable formulation that does not employ the combination of one or more sensates (at least one of which is a warming agent or a tingling agent), a sweetener and triacetin, while replicating smoking a cigarette.

[0508] 24. Use of about 0.001 to about 0.05 weight percent of a warming or tingling agent in a tobacco flavored aerosolizable formulation in combination with a sweetener and triacetin to alter the tobacco flavor intensity thereof.

[0509] 25. Use according to clause 24, wherein the aerosolizable formulation is characterized by the features according to any one of clauses 1 to 16.

[0510] The various embodiments described herein are intended only to assist in understanding and teaching the claimed features. These embodiments are provided only as representative samples of the various embodiments and are not exhaustive and / or exclusive. It should be understood that the advantages, embodiments, examples, functions, features, structures and / or other aspects described herein should not be regarded as limitations on the scope of the invention as defined by the claims or limitations on the equivalents of the claims, and other embodiments may be used and modified without departing from the scope of the invention as claimed. In addition to those specifically described herein, the various embodiments of the present invention may appropriately include, consist of or essentially consist of suitable combinations of the disclosed elements, components, features, parts, steps, devices, etc. In addition, the present disclosure may include other inventions that are not currently claimed but may be claimed in the future.

[0511] appendix

[0512]

[0513]

[0514]

[0515]

Claims

1. A consumable product for an aerosolizable formulation, wherein the consumable product comprises: (i) one or more sensates, wherein at least one sensate is a warming or tingling agent; (ii) sweeteners; and (iii) at least one compound which is a humectant and is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups.

2. The consumable product according to claim 1, wherein: At least one compound (iii) has a boiling point of at least about 200°C at atmospheric pressure.

3. The consumable product according to claim 2, wherein: At least one compound (iii) has a boiling point of at least about 200 to about 400°C at atmospheric pressure.

4. A consumable product according to any one of the preceding claims, wherein The C4-C 18 The hydrocarbyl ester is a glyceride.

5. The consumable product according to claim 4, wherein: The glyceride is diglyceride or triglyceride, preferably C4-C 16 Diglycerides or triglycerides.

6. The consumable product according to claim 5, wherein: The glyceride is a triglyceride, preferably wherein the glyceride is a C4-C 16 Triglycerides.

7. The consumable product according to claim 6, wherein: The triglyceride is glyceryl triacetate.

8. The consumable product according to any one of claims 1 to 3, wherein: The C4-C 18 Hydrocarbon esters are C4-C 18 Hydrocarbon partial esters.

9. The consumable product according to claim 8, wherein: The C4-C 18 Hydrocarbon partial esters are C4-C 18 Alkyl partial esters.

10. The consumable product according to claim 9, wherein: The C4-C 18 The alkyl partial ester is a trialkyl citrate.

11. The consumable product according to claim 10, wherein: The trialkyl citrate is triethyl citrate or tributyl citrate.

12. The consumable product according to any one of claims 1 to 3, wherein: The C4-C 18 Hydrocarbyl esters are compounds of formula (II): wherein R1 is an alkyl, alkenyl, alkynyl, aryl or aralkyl group, preferably an alkyl or alkenyl group; wherein R2, R3 and R4 are each independently selected from H, OH, alkyl, alkenyl, alkoxy or COOR' groups, said alkyl and alkenyl groups being optionally substituted with OH, alkoxy or COOR' groups, wherein each R' is independently alkyl or alkenyl, provided that the sum of the carbon atoms in R1, R2, R3, R4 and R' is 4-18.

13. The consumable product according to claim 12, wherein: At least one of R2, R3 and R4 is a COOR' group or an alkyl or alkenyl group substituted by a COOR' group, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms in R1, R2, R3, R4 and R' is 5-18, preferably at least two of R2, R3 and R4 are COOR' groups or alkyl or alkenyl groups substituted by a COOR' group, wherein each R' is independently an alkyl or alkenyl group, provided that the sum of the carbon atoms in R1, R2, R3, R4 and R' is 7-18.

14. The consumable product according to any one of claims 1 to 3, wherein: The C3-C 18 Hydrocarbon diols are C3-C 18 Alkyl glycol, preferably C3-C 12 Alkyl glycol.

15. The consumable product according to any one of claims 1 to 3, wherein: The C4-C 18 Hydrocarbon polyols are C4-C 18 Alkyl or alkenyl polyols, preferably C4-C 18 Alkyl glycol.

16. The consumable product according to claim 15, wherein: The C4-C 18 Hydrocarbon polyols are C4-C 16 Alkyl glycol.

17. A consumable product according to any one of the preceding claims, wherein At least one compound (iii) is selected from C4-C 18 Glycerides, C4-C 18 Hydrocarbon citrate, C3-C 18 Hydrocarbon diols and C4-C 18 Hydrocarbyl triols.

18. The consumable product according to claim 17, wherein: At least one compound (iii) is selected from C4-C 16 Triglycerides, C4-C 18 Hydrocarbon citrate and C3-C 16 Hydrocarbon diols.

19. A consumable product according to any one of the preceding claims, wherein The sweetener is a compound that binds to T1R2 and / or T1R3, or is a compound selected from oxadiazine sweeteners, aspartame sweeteners, sulfamate, calcium cyclamates, sugar alcohols, natural sweeteners, saccharin, sucralose, glucuronic acid and mixtures thereof.

20. A consumable product according to any one of the preceding claims, wherein The sweetener comprises at least one selected from aspartame, stevioside, monk fruit extract, glycyrrhizin, perilla, naringin dihydrochalcone, neohesperidin dihydrochalcone, mogroside V, rubusoside, raspberry extract, rebaudioside A, saccharin, sucralose and sodium cyclamate, preferably, the sweetener comprises at least one selected from acesulfame K, aspartame, neotame, saccharin, sucralose and sodium cyclamate.

21. A consumable product according to any one of the preceding claims, wherein The weight ratio of sensate to sweetener is from greater than about 1:1 to about 3:1, preferably wherein the weight ratio is from greater than about 1:1 to about 2:

1.

22. A consumable product according to any one of the preceding claims, wherein The one or more sensates further comprise a cooling agent, preferably wherein the cooling agent is selected from menthol, N,2,3-trimethyl-2-propan-2-ylbutanamide, N-ethyl-5-methyl-2-(propan-2-yl)cyclohexanecarboxamide, ethyl-2-[(5-methyl-2-propan-2-ylcyclohexanecarbonyl]amino]acetate, N-(4-methoxyphenyl)-p-menthanecarboxamide, N-(2-(pyridin-2-yl)ethyl)menthylcarboxamide, menthone-1,2-glycerol ketal, menthyl lactate, 3-(menthoxy)propane-1,2-diol, and menthyl succinate.

23. A consumable product according to any one of the preceding claims, wherein The warming agent or the tingling agent is selected from vanillin, sanshool, piperine, allyl isothiocyanate, cinnamyl phenylpropyl compound, ethyl ester and a combination thereof.

24. The consumable product according to claim 23, wherein: The warming agent or the tingling agent is vanillin or a combination thereof, preferably 3-phenylpropyl homovanillate.

25. A consumable product according to any one of the preceding claims, wherein The consumables also include one or more selected from 4-propylphenol, indole, 4-ethyl-2-methoxyphenol, 2-furylthiol, fenugreek lactone, 2,4-dimethylpyridine, 2-ethyl-3,5-dimethylpyrazine, 3-ethylphenol, furanone, β-damascenone, 2,6-dimethoxyphenol, geraniol, dimethyl trisulfide, 3-methylbutanal, acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylvaleric acid, butyric acid, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral, Tibetan A compound (iv) comprising maltol, maltol, ethyl maltol, 2-methoxyphenol, 4-methyl-2-methoxyphenol, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, phenylacetic acid, methylcyclopentenolone, ethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione, homomethylfuran, maple furanone, benzaldehyde, 4-propyl-2-methoxyphenol, 4-allyl-2,6-dimethoxyphenol, 3-methyl-2,4-nonanedione, 5,6,7-trimethylocta-2,5-dien-4-one or a combination thereof.

26. The consumable product according to claim 26, wherein: At least one compound (iv) is selected from compounds A, B, C, D, E and combinations thereof, wherein A is at least one compound selected from acetic acid, 2-methylbutyric acid, 3-methylbutyric acid, 3-methylpentanoic acid and butyric acid, preferably A is at least one compound selected from acetic acid, 3-methylbutyric acid, 3-methylpentanoic acid; B is at least one compound selected from β-damascenone, β-damascenone, β-ionone, α-ionone, α-ionol, β-cyclocitral and safranal, preferably B is at least one compound selected from β-damascenone, β-damascenone and β-ionone; C is at least one compound selected from maltol, ethyl maltol and trigonelline lactone, preferably C is a compound selected from maltol and trigonelline lactone; D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-dimethoxyphenol, phenylacetic acid, 3-hydroxy-4,5-dimethyl-2(5H)-furanone, methylcyclopentenolone, ethylmethylcyclopentenolone, 3,5-dimethyl-1,2-cyclohexanedione, homomethylfuran, maple furanone, 4-propyl-2-methoxyphenol, benzaldehyde and 4-allyl-2,6-diformylphenol, preferably D is at least one compound selected from 2-methoxyphenol, 4-methyl-2-methoxyphenol, 4-propyl-2-methoxyphenol, 2,6-methoxyphenol and phenylacetic acid; and E is at least one compound selected from 3-methyl-2,4-nonanedione and 5,6,7-trimethyl-octa-2,5-dien-4-one, and preferably E is 3-methyl-2,4-nonanedione.

27. An aerosolizable formulation for use in an aerosol delivery system, comprising a consumable product according to any preceding claim, a carrier and optionally nicotine.

28. The aerosolizable formulation according to claim 27, wherein The carrier is present in an amount of about 50 wt% or more based on the total weight of the formulation, preferably wherein the carrier is present in an amount of about 70 wt% or more based on the total weight of the formulation.

29. The aerosolizable formulation according to claim 27 or claim 28, wherein The carrier includes propylene glycol, glycerin, water or a combination thereof.

30. An aerosolizable formulation or an aerosol generating system comprising a consumable product according to any one of claims 1 to 26, an aerosol former material, one or more binders and optionally a botanical material, preferably wherein the one or more binders consist of one or more gelling agents.

31. An aerosolizable formulation according to any one of claims 27 to 30 or an aerosol generating system according to claim 30, comprising from about 0.0001 wt% to about 5 wt% of the one or more sensates and from about 1 wt% to less than about 35 wt% of at least one compound (iii), preferably from about 0.0001 wt% to about 3 wt% of the one or more sensates and from about 1 wt% to less than about 30 wt% of at least one compound (iii).

32. An aerosolizable formulation according to any one of claims 27 to 31 or an aerosol generating system according to claim 30 or claim 31 , wherein The one or more sensates are present in a concentration of about 0.0001 wt% to about 2.5 wt%, about 0.0001 wt% to about 1 wt%.

33. An aerosolizable formulation according to any one of claims 27 to 32 or an aerosol generating system according to any one of claims 30 to 32, wherein The preparation or the consumable is in liquid or gel form.

34. An article comprising the aerosolizable formulation according to any one of claims 27 to 33.

35. An article according to claim 34, comprising a storage member for receiving an aerosolizable formulation according to any one of claims 27 to 33, an aerosol-generating component, an aerosol-generating region, a transport element and optionally a mouthpiece, preferably wherein the aerosol-generating component comprises a heater and / or wherein the transport element is a wick.

36. An aerosol supply system comprising an aerosol supply device and an article according to claim 34 or claim 35, preferably wherein the aerosol supply device is non-flammable.

37. A method for forming an aerosol, the method comprising providing an aerosolizable formulation as defined in any one of claims 27 to 33, an aerosol generating system as defined in any one of claims 30 to 33 or an aerosol supply system as defined in claim 36, and aerosolizing the formulation or the consumable in the system.

38. Use of from about 0.0001 wt% to about 5 wt% of one or more sensates in combination with a sweetener and a compound that is a humectant to modify at least one sensory property of an aerosolizable formulation or an aerosol generating system, wherein at least one sensate is a warming or tingling agent, wherein the compound has a boiling point of at least about 200°C at atmospheric pressure, preferably wherein the aerosolizable formulation is characterized by the features of any one of claims 27 to 33, or wherein the aerosol generating system is characterized by the features of any one of claims 30 to 33.

39. About 0.0001 wt% to about 5 wt% of one or more sensates with a sweetener and a humectant and a C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 Use of a compound combination of hydrocarbon-based polyols to modify at least one sensory property of an aerosolizable formulation or an aerosol-generating system, wherein at least one sensate is a warming or tingling agent, wherein the polyol comprises three or more hydroxyl groups, preferably wherein the aerosolizable formulation is characterized by the features of any one of claims 27 to 33, or wherein the aerosol-generating system is characterized by the features of any one of claims 30 to 33.

40. The use according to claim 38 or claim 39, wherein The sensory property is selected from the group consisting of taste, mouthfeel, smoking experience, and combinations thereof, and wherein the sensory property is altered relative to an aerosolizable formulation or aerosol generating system that does not employ the combination of one or more sensate, sweetener, and humectant compounds, and wherein at least one sensate is a warming agent or a tingling agent.

41. The use according to claim 40, wherein The modification of the organoleptic properties provides an aerosolizable formulation or an aerosol generating system that replicates the smoking of a combustible tobacco product, preferably a cigarette.

42. Use of a humectant having a boiling point of at least about 200°C at atmospheric pressure to modify the mouthfeel of an aerosolizable formulation or an aerosol generating system, wherein the mouthfeel modification replicates one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

43. Use of a humectant to modify the mouthfeel of an aerosolizable formulation or an aerosol generating system, wherein the humectant is C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups, wherein the mouthfeel is modified to replicate one or more sensations of smoking a combustible tobacco product, preferably a cigarette.

44. The use according to claim 42 or 43, wherein The aerosolizable formulation or the aerosol generating system further comprises at least one sensate and / or sweetener, the sensate being a warming agent or a tingling agent.

45. Use of about 0.0001 to about 5 wt% of a warming or tingling agent in combination with a sweetener and a compound as a humectant in a tobacco-flavored aerosolizable formulation or an aerosol generating system to alter the tobacco flavor intensity of a consumable product in said formulation or said system, wherein said humectant compound has a boiling point of at least about 200° C. at atmospheric pressure and / or is a C4-C 18 Hydrocarbon esters, C3-C 18 Hydrocarbon diol or C4-C 18 A hydrocarbyl polyol, wherein the polyol comprises three or more hydroxyl groups.

46. The use according to any one of claims 42 to 45, wherein The aerosolizable formulation is characterized by the features according to any one of claims 27-33, or wherein the aerosol generating system is characterized by the features according to any one of claims 30-33.

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