A bone defect repair device

Abstract

The application discloses a bone defect repairing device, which comprises a repairing part, wherein the repairing part uses titanium alloy as a main material as a metal implant, top and bottom walls of the repairing part are provided with extension assemblies, the repairing part is internally provided with a porous assembly, outer wall edges of the repairing part are uniformly provided with a plurality of fixing assemblies, and outer edges of the top and bottom walls of the repairing part are provided with release assemblies; the porous assembly comprises outer wall holes, a plurality of the outer wall holes are uniformly arranged on the top wall of the repairing part, and the bottom wall of the repairing part is uniformly provided with a plurality of inner wall holes, and the application relates to the technical field of bone repairing; the bone defect repairing device is provided with the porous assembly, the elastic modulus and stress shielding effect can be reduced through the multi-gradient pore size gradient change, the bone tissue is close to the inner wall holes, the bone is conveniently grown into the inner wall holes, the internal strength of the implant is increased, the biocompatibility is good, the rejection reaction is reduced, and the porous structure promotes the bone growth.

Description

Technical Field

[0001] This invention relates to the field of bone repair technology, specifically a bone loss repair device. Background Technology

[0002] Bone loss repair devices refer to a general term for medical devices or biomaterials used to repair bone defects or missing parts caused by trauma, infection, tumor resection, congenital malformation or degenerative diseases. They are a combination of materials, devices or technologies used to fill, repair and reconstruct missing bone tissue. They range from traditional autologous bone and allogeneic bone to artificially synthesized ceramics and polymers, to advanced metal implants (especially 3D printing), bioactive materials carrying growth factors or cells (tissue engineering products), and biomembranes that guide regeneration.

[0003] Regarding the aforementioned technologies, the applicant believes that: Currently, some bone repair components made of materials such as titanium alloys have become core materials for repairing defects in load-bearing parts due to their high specific strength and good biocompatibility. However, they have certain shortcomings in use, such as the problem of excessively high elastic modulus of the metal, which leads to stress shielding.

[0004] Therefore, the present invention provides a bone loss repair device to solve the above-mentioned problems. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a bone defect repair device that solves the aforementioned problems.

[0006] To achieve the above objectives, the present invention is implemented through the following technical solution: a bone loss repair device, comprising a repair component, wherein the repair component is a metal implant using titanium alloy as the main material, an extension component is installed on both the top and bottom walls of the repair component, a porous component is installed inside the repair component, a plurality of fixing components are evenly installed on the outer edge of the repair component, and a release component is installed at the outer edge of both the top and bottom walls of the repair component.

[0007] The porous component includes an outer wall hole, and a plurality of the outer wall holes are evenly opened at the top wall position of the repair component. A plurality of inner wall holes are evenly opened at the bottom wall of the repair component, and the plurality of the outer wall holes are all connected to the corresponding inner wall holes.

[0008] The porosity of the outer wall holes formed in the dense layer on the outer wall of the repair component is about 10%, and the porosity of the inner wall holes formed in the inner wall of the repair component is about 70%. The outer wall holes and inner wall holes on the repair component are a gradient porous design, and the pore size gradient of the outer wall holes and inner wall holes is 200μm on the surface → 600μm in the core.

[0009] The modulus of several outer wall holes is approximately 80 GPa, and the modulus of several inner wall holes is approximately 3-20 GPa. Through a multi-level gradient design, the outer and inner wall holes on the repair component can reduce the elastic modulus and stress shielding effect, and are close to bone tissue to facilitate bone ingrowth into the inner wall holes. At the same time, the internal strength of the implant is increased.

[0010] Through the above technical solution, the porous component is designed with gradient pore diameters for the outer and inner walls, which can reduce the elastic modulus and stress shielding effect of the repair component, thereby increasing the internal strength of the repair component and providing necessary mechanical support during bone healing.

[0011] Furthermore, the outer wall of the repair component is uniformly coated with a hydroxyapatite coating or graphene oxide, which can reduce the immune response, modify the surface of the titanium alloy of the repair component, and improve its biocompatibility.

[0012] The above technical solution modifies the surface of the repair component, thereby improving its biocompatibility with bone tissue and surrounding tissues.

[0013] Furthermore, the extension component includes two sets of stress relief grooves, which are arranged symmetrically from top to bottom. Each set of stress relief grooves consists of four grooves, which are evenly distributed at the four corners of the outer wall of the repair component. The stress relief grooves are mainly used for stress relief during use of the repair component. The arrangement of the stress relief grooves prevents stress concentration from causing deformation or damage to the internal structure of the repair component.

[0014] The above technical solution addresses the issue of stress concentration when the repair component provides mechanical support to bone tissue. By incorporating stress relief grooves at the four corners of the repair component, stress can be released during mechanical support, preventing structural damage to the component.

[0015] Furthermore, the top and bottom walls of the repair component are uniformly provided with a plurality of extension grooves at positions corresponding to the outer and inner wall holes. Each of the extension grooves is provided with a connecting groove. The connecting grooves on the top wall of the repair component are connected to the corresponding outer wall holes, and the connecting grooves on the bottom wall of the repair component are connected to the corresponding inner wall holes. The arrangement of the extension grooves and connecting grooves is for the coverage and connection growth of bone tissue and surrounding tissue.

[0016] Through the above technical solution, when the extension groove and the connecting groove are set and connected to the inner wall hole, a surface or groove body is provided so that the host bone cells can crawl and grow along its surface or pores.

[0017] Furthermore, the fixing component includes a fixing member, one end of which is fixedly connected to the outer wall of the repair component. The top wall of the fixing member has a receiving opening, and the bottom wall of the fixing member has a through opening corresponding to the receiving opening. The through opening and the receiving opening are connected.

[0018] The above technical solution connects the receiving port and the through port on the fastener, which is mainly used for installing fasteners.

[0019] Furthermore, fasteners for fixing the repair piece are installed on the inner walls of both the receiving port and the through port. These fasteners are mainly screwed to and fixed to the surrounding bone tissue.

[0020] Through the above technical solution, the fasteners are mainly screwed and fixed to the surrounding bone tissue, which can install and fix the repair parts.

[0021] Furthermore, the release component includes a pH-sensitive hydrogel rod, the front and rear parts of which are fixedly connected to the bottom wall of the repair component via a fixing seat. The pH-sensitive hydrogel rod is mainly used to release antibiotics when tissue infection occurs.

[0022] Through the above technical solution, pH-sensitive hydrogel rods are mainly used to release antibiotics when tissue infection occurs, reducing the problem of inflammation or rejection reaction of repair parts.

[0023] Furthermore, the top and bottom walls of the repair component are uniformly provided with receiving annular grooves, the inner walls of the two receiving annular grooves are each covered with double-sided adhesive, the front and rear parts of the outer walls of the two double-sided adhesives are each covered with several growth factor microspheres, the left and right sides of the outer walls of the two double-sided adhesives are each covered with several bioactive ion spheres, and the inner walls of the two receiving annular grooves are each equipped with a protective film.

[0024] The protective film, as described above, is designed to protect growth factor microspheres and bioactive ion spheres. The protective film is removed during the installation of the repair component.

[0025] Furthermore, the growth factor microspheres and bioactive ion spheres all use a PLGA shell approximately 10 μm thick. The release curves of the growth factor microspheres and bioactive ion spheres are: burst release <20% within 7 days, sustained release >70% within 30 days. The growth factor microspheres are mainly used to directly direct stem cell differentiation and angiogenesis through time-controlled release of signaling molecules, and to promote the differentiation of mesenchymal stem cells into osteoblasts, thus solving the problems of short half-life and burst release failure of traditional growth factors. The bioactive ion spheres are mainly used to regulate bone metabolism balance and antibacterial immune microenvironment through continuous release of metal ions, thus solving the problems of biological inertness and infection risk of metal materials.

[0026] The above technical solution, through the setting of growth factor microspheres and bioactive ion spheres, can stimulate the differentiation of undifferentiated mesenchymal stem cells in the host into osteoblasts and regulate bone metabolism balance and antibacterial immune microenvironment.

[0027] Furthermore, several triangular protrusions are evenly fixedly installed on the front and rear walls of the repair component, and all of the triangular protrusions are arranged with their planes facing upwards.

[0028] The above technical solution allows for the use of triangular protrusions to hook and fix bone tissue during the installation of the repair component, thereby providing auxiliary fixation for the repair component. Beneficial effects

[0029] This invention provides a bone loss repair device. Compared with the prior art, it has the following advantages:

[0030] (1) The bone loss repair device, through the setting of porous components and the multi-gradient pore size gradient, can reduce the elastic modulus and stress shielding effect, approach the bone tissue to facilitate bone ingrowth into the inner wall pores, and at the same time increase the internal strength of the implant, resulting in good biocompatibility, reducing rejection reaction, and the porous structure promotes bone ingrowth.

[0031] (2) The bone loss repair device, through the setting of the fixing components, when installing the titanium alloy repair part, is screwed to the bone tissue and surrounding structures by fasteners, and abuts against the bone tissue by the triangular protrusion, thereby achieving the fixation of the repair part.

[0032] (3) The bone loss repair device, through the setting of the extension component, the extension groove and the connecting groove, enables the host bone cells to crawl and grow along its surface or pores, so that the repair part has osteoconductive properties. At the same time, the stress relief groove is set. When the repair part provides necessary mechanical support during the bone healing process, there will be a certain stress concentration. By setting the stress relief groove at the four corners of the repair part, stress concentration can be prevented to avoid structural damage to the repair part.

[0033] (4) The bone loss repair device, through the setting of the release component, allows the protective film to be torn open when using growth factor microspheres and bioactive ion spheres so that they can come into contact with external bone tissue. The growth factor microspheres are mainly used to directly command stem cell differentiation and angiogenesis through time-controlled release of signal molecules, and promote the differentiation of mesenchymal stem cells into osteoblasts, thus solving the problems of short half-life and burst release failure of traditional growth factors. The bioactive ion spheres are mainly used to regulate bone metabolism balance and antibacterial immune microenvironment by continuously releasing metal ions, thus solving the problems of biological inertness and infection risk of metal materials. Attached Figure Description

[0034] Figure 1 This is a front view of the overall structure of the present invention;

[0035] Figure 2 This is a top view of the external structure of the present invention;

[0036] Figure 3 This is a bottom view of the external structure of the present invention;

[0037] Figure 4 This is a schematic diagram of the external structure of the present invention on the right side;

[0038] Figure 5 This is an exploded view of the internal structure of the release component of the present invention;

[0039] Figure 6 This is the invention Figure 5 Enlarged view of the structure at point A;

[0040] Figure 7 This is a schematic diagram of the internal structure of the release component of the present invention when opened;

[0041] Figure 8 This is a schematic diagram of the external structure of the repair component of the present invention.

[0042] In the diagram: 1. Repair component; 2. Fixing component; 21. Fixing component; 22. Fastener; 23. Through port; 24. Receiving port; 3. Extension component; 31. Stress relief groove; 32. Extension groove; 33. Connecting groove; 4. Release component; 41. Receiving ring groove; 42. Double-sided adhesive; 43. Growth factor microspheres; 44. Bioactive ion spheres; 45. Protective film; 46. pH-sensitive hydrogel rod; 47. Fixing base; 5. Porous component; 51. Outer wall hole; 52. Inner wall hole; 6. Triangular protrusion. Detailed Implementation

[0043] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0044] Example 1

[0045] Please see Figure 1-8 A bone loss repair device includes a repair component 1, which is a metal implant made of titanium alloy as the main material. The top and bottom walls of the repair component 1 are equipped with extension components 3. The inside of the repair component 1 is equipped with a porous component 5. Several fixing components 2 are evenly installed on the outer edge of the repair component 1. Release components 4 are installed on the outer edges of the top and bottom walls of the repair component 1.

[0046] The porous component 5 includes an outer wall hole 51. Several outer wall holes 51 are evenly opened on the top wall of the repair component 1. Several inner wall holes 52 are evenly opened on the bottom wall of the repair component 1. Several outer wall holes 51 are connected to the corresponding inner wall holes 52.

[0047] The porosity of the outer wall holes 51 formed in the dense layer of the outer wall of the repair part 1 is about 10%, and the porosity of the outer wall holes 51 formed in the inner wall of the repair part 1 is about 70%. The several outer wall holes 51 and inner wall holes 52 on the repair part 1 are designed with a gradient porous structure. The pore size gradient of the outer wall holes 51 and inner wall holes 52 is 200μm on the surface → 600μm in the core.

[0048] The modulus of several outer wall holes 51 is about 80 GPa, and the modulus of several inner wall holes 52 is about 3-20 GPa. Through multi-level gradient design, the outer wall holes 51 and inner wall holes 52 on the repair component 1 can reduce the elastic modulus and stress shielding effect, and are close to bone tissue to facilitate bone ingrowth into the inner wall holes 52. At the same time, the internal strength of the implant is increased.

[0049] The outer wall of repair part 1 is uniformly sprayed with a hydroxyapatite coating or graphene oxide, which can reduce the immune response and modify the surface of the titanium alloy of repair part 1 to improve biocompatibility.

[0050] In this embodiment of the invention, the purpose of this arrangement is that the porous component 5 can reduce the elastic modulus of the repair component 1 and avoid the problem of stress shielding effect. With the design of the gradient change of the pore size of the outer wall hole 51 and the inner wall hole 52, it is convenient for bone tissue to connect and grow into the outer wall hole 51 and the inner wall hole 52, so as to increase the overall strength of the repair component 1.

[0051] When a hydroxyapatite coating or graphene oxide is uniformly sprayed onto the surface of the repair component 1, the surface of the repair component 1 can be modified, improving biocompatibility and reducing the probability of inflammation or rejection.

[0052] Example 2

[0053] Please see Figure 1-8This embodiment provides a technical solution based on embodiment one: the extension component 3 includes two sets of stress relief grooves 31, which are arranged symmetrically in the upper and lower parts. Each set of stress relief grooves 31 consists of four grooves, which are evenly distributed at the four corners of the outer wall of the repair component 1. The stress relief grooves 31 are mainly used for stress relief during use of the repair component 1. The arrangement of the stress relief grooves 31 prevents stress concentration from causing deformation or damage to the internal structure of the repair component 1. Several extension grooves 32 are evenly opened on the top and bottom walls of the repair component 1, corresponding to the outer wall holes 51 and inner wall holes 52. Each extension groove 32 has a connecting groove 33. The connecting grooves 33 on the top wall of the repair component 1 are connected to the corresponding outer wall holes 51, and the connecting grooves 33 on the bottom wall of the repair component 1 are connected to the corresponding inner wall holes 52. The extension grooves 32 and the connecting grooves 33 are used for the growth of bone tissue and surrounding tissue covering and connecting.

[0054] In this embodiment of the invention, the purpose of this arrangement is that the extension component 3 is connected to the inner wall hole 52 through the designed extension groove 32 and connecting groove 33. It is mainly used to provide a crawling growth guidance area for the growth of bone tissue and surrounding tissue. When the repair component 1 is used to mechanically support the bone tissue, stress concentration will occur. The stress is relieved by stress relief groove 31 to prevent structural changes or damage to the repair component 1.

[0055] Example 3

[0056] Please see Figure 1-8 This embodiment provides a technical solution based on embodiment one: the fixing component 2 includes a fixing member 21, one end of the fixing member 21 is fixedly connected to the outer wall of the repair member 1, the top wall of the fixing member 21 is provided with a receiving opening 24, the bottom wall of the fixing member 21 is provided with a through opening 23 at the position corresponding to the receiving opening 24, the through opening 23 and the receiving opening 24 are connected, and fasteners 22 for fixing the repair member 1 are installed on the inner walls of the receiving opening 24 and the through opening 23. The fasteners 22 are mainly screwed and fixed to the surrounding bone tissue.

[0057] In this embodiment of the invention, the purpose of this arrangement is that the fixing component 2, after the fastener 22 passes through the receiving port 24 and the through port 23, is screwed and fixed to the bone tissue around the repair component 1, thereby providing a stable fixing effect on the repair component 1.

[0058] Example 4

[0059] Please see Figure 1-8This embodiment provides a technical solution based on Embodiment 1: the release component 4 includes a pH-sensitive hydrogel rod 46. The front and rear parts of the outer wall of the pH-sensitive hydrogel rod 46 are fixedly connected to the bottom wall of the repair component 1 through fixing seats 47. The pH-sensitive hydrogel rod 46 is mainly used to release antibiotics when tissue infection occurs. The top and bottom walls of the repair component 1 are evenly provided with receiving ring grooves 41. Double-sided tape 42 is pasted on the inner wall of each of the two receiving ring grooves 41. Several growth factor microspheres 43 are pasted on the front and rear parts of the outer wall of each of the two double-sided tapes 42. Several bioactive ion balls 44 are pasted on the left and right sides of the outer wall of each of the two double-sided tapes 42. A protective film 45 is installed on the inner wall of each of the two receiving ring grooves 41. Several growth factor microspheres 43 and bioactive ion spheres 44 are all encased in PLGA shells approximately 10 μm thick. The release curves of the growth factor microspheres 43 and bioactive ion spheres 44 show a burst release of <20% within 7 days and a sustained release of >70% within 30 days. The growth factor microspheres 43 are mainly used to directly direct stem cell differentiation and angiogenesis through time-controlled release of signaling molecules, and to promote the differentiation of mesenchymal stem cells into osteoblasts, thus solving the problems of short half-life and burst release failure of traditional growth factors. The bioactive ion spheres 44 are mainly used to regulate bone metabolism balance and antibacterial immune microenvironment through the continuous release of metal ions, thus solving the problems of biological inertness and infection risk of metal materials.

[0060] Several triangular protrusions 6 are evenly fixedly installed on the front and rear walls of the repair component 1, and all the triangular protrusions 6 are arranged with the plane facing upward.

[0061] In this embodiment of the invention, the purpose of this setting is that the pH-sensitive hydrogel rod 46 provided by the release component 4 can improve the biocompatibility of the repair component 1 and reduce the problems of inflammation and rejection. The growth factor microspheres 43 and bioactive ion spheres 44 are provided to promote the differentiation of mesenchymal stem cells into osteoblasts and regulate the balance of bone metabolism and the antibacterial immune microenvironment.

[0062] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0063] The working principle of this device is as follows: The repair component 1 is made of titanium alloy and serves as the main material for repairing bone defects. The repair component 1 can be installed at the location of the bone defect through the fixed component 2. The movable fastener 22 passes through the receiving port 24 and the through port 23 on the fixed component 21 and is screwed to the surrounding bone tissue for fixation. The triangular protrusion 6 is inserted into the surrounding tissue to provide auxiliary fixation for the repair component 1, thereby installing and fixing the repair component 1.

[0064] The extension component 3 releases the stress of the repair component 1 and guides the growth of bone tissue. The stress relief groove 31 is mainly used to release the stress of the repair component 1 during use, preventing stress concentration from causing internal structural changes or structural damage. The extension groove 32 and the connecting groove 33 are connected to the inner wall hole 52. When bone tissue or surrounding tissue grows, it can pass through the inner wall hole 52, the extension groove 32 and the connecting groove 33 to connect with each other, so that the bone tissue has connection and support strength after growth.

[0065] The release component 4 is designed to release antibiotics via pH-sensitive hydrogel rods 46 when tissue infection occurs, thereby inhibiting the infection and promoting the normal growth of bone tissue and surrounding tissues. When installing the repair component 1, the protective film 45 is removed from the surface of the receiving ring groove 41 on the repair component 1, exposing the growth factor microspheres 43 and bioactive ion spheres 44 attached to the double-sided adhesive 42 in the receiving ring groove 41 to the bone tissue and surrounding tissues. The growth factor microspheres 43 are mainly used to directly direct stem cell differentiation and angiogenesis through time-controlled release of signal molecules, and promote the differentiation of mesenchymal stem cells into osteoblasts, solving the problems of short half-life and burst release failure of traditional growth factors. The bioactive ion spheres 44 are mainly used to regulate bone metabolism balance and antibacterial immune microenvironment by continuously releasing metal ions, solving the problems of biological inertness and infection risk of metal materials.

[0066] The porous component 5 reduces the elastic modulus and stress shielding effect, and its proximity to bone tissue facilitates bone ingrowth into the inner wall pore 52. At the same time, the internal strength of the implant is increased. The outer wall of the repair component 1 is uniformly coated with a hydroxyapatite coating or graphene oxide, which can reduce the immune response. The surface modification of the titanium alloy of the repair component 1 and the improvement of biocompatibility are achieved. The multi-level gradient design of the outer wall pore 51 and inner wall pore 52 on the outer and inner walls of the repair component 1 can reduce the elastic modulus and stress shielding effect.

[0067] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0068] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A bone loss repair device, comprising a repair component (1), characterized in that: The repair component (1) is a metal implant made of titanium alloy as the main material. The top and bottom walls of the repair component (1) are equipped with extension components (3). The inside of the repair component (1) is equipped with a porous component (5). Several fixing components (2) are evenly installed on the outer edge of the repair component (1). Release components (4) are installed on the outer edges of the top and bottom walls of the repair component (1). The porous component (5) includes an outer wall hole (51), and a plurality of the outer wall holes (51) are evenly opened at the top wall position of the repair component (1). A plurality of inner wall holes (52) are evenly opened at the bottom wall of the repair component (1), and the plurality of the outer wall holes (51) are all connected to the corresponding inner wall holes (52). The porosity of the outer wall holes (51) formed in the dense layer of the outer wall of the repair component (1) is 10%, and the porosity of the inner wall holes (52) formed in the inner wall of the repair component (1) is 70%. The outer wall holes (51) and inner wall holes (52) on the repair component (1) are a gradient porous design, and the pore size gradient of the outer wall holes (51) and inner wall holes (52) is 200 μm on the surface → 600 μm in the core. The modulus of several outer wall holes (51) is 80 GPa, and the modulus of several inner wall holes (52) is 3-20 GPa. The outer wall holes (51) and inner wall holes (52) on the repair component (1) are designed with a multi-level gradient to reduce the elastic modulus and stress shielding effect, and to be close to bone tissue to facilitate bone ingrowth into the inner wall holes (52). At the same time, the internal strength of the implant is increased. The extension component (3) includes two sets of stress relief grooves (31), which are arranged symmetrically up and down. Each set of stress relief grooves (31) consists of four grooves, which are evenly distributed at the four corners of the outer wall of the repair component (1). The stress relief grooves (31) are mainly used for stress relief during use of the repair component (1). The arrangement of the stress relief grooves (31) prevents stress concentration from causing deformation or damage to the internal structure of the repair component (1). The release component (4) includes a pH-sensitive hydrogel rod (46). The front and rear parts of the outer wall of the pH-sensitive hydrogel rod (46) are fixedly connected to the bottom wall of the repair component (1) through a fixing seat (47). The pH-sensitive hydrogel rod (46) is mainly used to release antibiotics when tissue infection occurs. The repair component (1) has uniformly formed receiving annular grooves (41) on its top and bottom walls. Double-sided adhesive tape (42) is pasted on the inner walls of both receiving annular grooves (41). Several growth factor microspheres (43) are pasted on the front and back parts of the outer walls of both double-sided adhesive tapes (42). Several bioactive ion spheres (44) are pasted on the left and right sides of the outer walls of both double-sided adhesive tapes (42). A protective film (45) is installed on the inner walls of both receiving annular grooves (41).

2. The bone loss repair device according to claim 1, characterized in that: The outer wall of the repair component (1) is uniformly sprayed with a hydroxyapatite coating or graphene oxide, which can reduce the immune response, modify the surface of the titanium alloy of the repair component (1), and improve its biocompatibility.

3. The bone loss repair device according to claim 1, characterized in that: The repair component (1) has a plurality of extension grooves (32) evenly provided on its top and bottom walls, corresponding to the outer wall hole (51) and inner wall hole (52). Each of the extension grooves (32) has a connecting groove (33). The connecting grooves (33) on the top wall of the repair component (1) are connected to the corresponding outer wall hole (51), and the connecting grooves (33) on the bottom wall of the repair component (1) are connected to the corresponding inner wall hole (52). The extension grooves (32) and connecting grooves (33) are provided for the growth of bone tissue and surrounding tissue covering and connecting.

4. The bone loss repair device according to claim 1, characterized in that: The fixing component (2) includes a fixing member (21), one end of which is fixedly connected to the outer wall of the repair component (1). The top wall of the fixing member (21) is provided with a receiving opening (24), and the bottom wall of the fixing member (21) is provided with a through opening (23) corresponding to the receiving opening (24). The through opening (23) and the receiving opening (24) are connected.

5. The bone loss repair device according to claim 4, characterized in that: The inner walls of the receiving port (24) and the through port (23) are equipped with fasteners (22) for fixing the repair piece (1), and the fasteners (22) are mainly screwed to the surrounding bone tissue for fixation.

6. The bone loss repair device according to claim 1, characterized in that: The growth factor microspheres (43) and bioactive ion spheres (44) all use PLGA shells with a thickness of 10 μm. The release curves of the growth factor microspheres (43) and bioactive ion spheres (44) are <20% burst release within 7 days and >70% sustained release within 30 days. The growth factor microspheres (43) are mainly used to directly direct stem cell differentiation and angiogenesis through time-controlled release of signaling molecules, and promote the differentiation of mesenchymal stem cells into osteoblasts, thus solving the problems of short half-life and burst release failure of traditional growth factors. The bioactive ion spheres (44) are mainly used to regulate bone metabolism balance and antibacterial immune microenvironment through continuous release of metal ions, thus solving the problems of biological inertness and infection risk of metal materials.

7. The bone loss repair device according to claim 1, characterized in that: The repair component (1) has several triangular protrusions (6) evenly fixed on its front and rear walls, and all of the triangular protrusions (6) are arranged with their planes facing upwards.

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