Formula and preparation method of Liuwei Dihuang drink

Abstract

The formula comprises the following raw materials in percentage by weight: 0.1 to 0.2 percent of radix angelicae sinensis, 0.1 to 0.2 percent of spica prunellae, 2 to 6 percent of brown granulated sugar, 0.01 to 0.08 percent of radix rehmanniae praeparata extract, 0.01 to 0.08 percent of fructus corni extract, 0.01 to 0.08 percent of rhizoma dioscoreae extract, 0.01 to 0.08 percent of poria cocos extract and the balance of water. The traditional Chinese medicine raw materials are prepared into the traditional Chinese medicine health-care potion, and the traditional Chinese medicine health-care potion has the core effects of enriching yin and nourishing kidney, promoting blood circulation and regulating menstruation, and clearing heat and removing stasis, and is suitable for various diseases caused by deficiency of liver-yin and kidney-yin, blood stasis and stagnation or heat toxin accumulation, such as soreness and weakness of waist and knees, irregular menstruation, scrofula, gall and the like; the bitter taste of part of medicinal materials such as selfheal and prepared rehmannia root can be neutralized, so that the whole taste of the potion is more balanced, and the potion is easier to accept by people in taste compared with prepared pills.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine nourishing prescriptions, and particularly relates to a formula of a traditional Chinese medicine Liuwei Dihuang Decoction and a preparation method thereof. Background Art

[0002] Liuwei Dihuang Pills are a traditional Chinese medicine prescription developed according to TCM theory, mainly used to nourish yin and tonify the kidney. Nowadays, high pressure in life, frequent staying up late, excessive fatigue, etc. have caused the body to be in a sub-healthy state, showing symptoms of kidney yin deficiency. As people age, their various body functions gradually decline, and the elderly may experience symptoms of kidney yin deficiency. Liuwei Dihuang Pills can be used for conditioning, but the current ingredients and efficacy of Liuwei Dihuang Pills are relatively simple.

[0003] Patent CN120000742A discloses a concentrated Liuwei Dihuang Pill and its preparation method. On the basis of traditional Liuwei Dihuang Pill, nourishing agents, nourishing agents and supplements are specially added. The effective ingredients in the nourishing agents can nourish yin and moisten the lungs, benefit the kidneys and consolidate essence, and nourish the spleen and replenish qi, which is helpful for men's health. It can nourish the kidneys and protect the liver, strengthen yang and consolidate essence, and is beneficial for people with sexual neurasthenia such as impotence, premature ejaculation, and spermatorrhea. At the same time, the nourishing agents can effectively nourish the body and reduce the damage caused to the human body by tobacco and alcohol. Oyster essence powder is added, which is rich in taurine, glycogen and physiologically active substances unique to marine organisms, essential amino acids for the human body and a large number of trace elements beneficial to the human body, and has a good nourishing effect on the human body.

[0004] CN115340920A discloses a health-care liquor blended with Chinese medicinal herbs such as Rehmannia root, Momordica grosvenori, Salvia miltiorrhiza, Codonopsis pilosula, Astragalus membranaceus, and dried tangerine peel. This liquor has a medicinal taste and a liquor-like flavor, and has health-care functions, as well as the effects of protecting organs and preventing diseases. It can be consumed in small amounts for long periods of time. This liquor is different from traditional health-care liquors and other health-care liquors in that it has no medicinal taste and retains the liquor-like flavor.

[0005] In order to further meet people's needs for health care and promote Chinese traditional medicine culture, it is necessary to further expand Liuwei Dihuang Pills and develop a new health drink that not only has a health care effect in function, but is also more easily accepted by people in terms of taste, flavor and style. Summary of the Invention

[0006] The purpose of the present invention is to provide a formula of Liuwei Dihuang Drink, and providing a preparation method thereof is another purpose of the present invention.

[0007] In order to achieve the above-mentioned object of the invention, the present invention adopts the following technical solutions: A formula for a traditional Chinese medicine drink, Liuwei Dihuang Decoction, is composed of the following raw materials in percentage by weight: 0.1-0.2% of angelica sinensis, 0.1-0.2% of selfheal, 2-6% of brown sugar, 0.01-0.08% of prepared rehmannia root extract, 0.01-0.08% of cornus officinalis extract, 0.01-0.08% of yam extract, 0.01-0.08% of poria cocos extract, and the balance of water.

[0008] The Rehmannia root extract, Cornus officinalis extract, Chinese yam extract and Poria cocos extract are all in powder form, and 95% of the particle size passes through an 80-mesh sieve.

[0009] The preparation method of the Chinese medicine Liuwei Dihuang Decoction comprises the following steps: 1) Wrapping the angelica and prunella vulgaris and soaking them in purified water at 80-100°C for 20-30 minutes, then heating the soaked angelica and prunella vulgaris in a mixing tank for extraction at 90-100°C for 60-80 minutes. After the extraction is complete, remove the angelica and prunella vulgaris residue to obtain the angelica and prunella vulgaris extract. 2) Add Rehmannia root extract, Cornus officinalis extract, Chinese yam extract, Poria cocos extract, and brown sugar in proportion to the mixing tank, stir for 10-15 minutes, filter through a 150-mesh filter, and let the filtrate enter a temporary storage tank. Add 70-85℃ purified water to continuously rinse the residual liquid in the mixing tank and pipeline until the temporary storage tank is fixed to 5000L, and stir for 20-30 minutes to obtain the fixed volume solution; 3) The constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for two homogenizations. The homogenization pressure of the first high-pressure homogenizer is set to 30-35Mpa, and the homogenization pressure of the second high-pressure homogenizer is set to 45-50Mpa. After homogenization, the homogenized liquid is pumped into a 3-ton temporary storage tank; 4) After the printed cans are cleaned inside and out with purified water, they are transported to the filling machine via a conveyor belt. The filling port of the filling machine is adjusted to the 242.4g mass scale. The filling volume must not be less than 233.4g before filling. 5) Place the filled finished product into the autoclave, set the sterilization temperature to 121-125℃, and the sterilization time to 18-20min. After sterilization, cool it down.

[0010] Preferably, in step 1), the soluble solids content of the angelica and prunella vulgaris extract should be 0.2% to 0.6%, the density should be 0.996 to 1.000, and the pH value should be 5.6 to 6.2.

[0011] Preferably, in step 2), the soluble solids content of the constant volume solution should be 3.2% to 3.7%, the density should be 1.006 to 1.012, and the pH value should be 5.2 to 5.8.

[0012] Preferably, in step 3), the homogenized liquid has a soluble solid content of 3.2% to 3.7%, a density of 1.006 to 1.012, and a pH of 5.2 to 5.8.

[0013] Preferably, in step 5), the soluble solids content of the sterilized sample should be 3.2% to 3.7%, the density should be 1.008 to 1.012, and the pH value should be 5.1 to 5.5.

[0014] In the present invention, the functions and effects of each raw material are as follows: Angelica sinensis, efficacy: tonifying blood and activating blood circulation, regulating menstruation and relieving pain, moistening intestines and promoting bowel movements; Effect: Targeting symptoms such as blood deficiency, sallow complexion, dizziness, palpitations, and irregular menstruation, it improves blood circulation by tonifying blood and activating blood circulation, and relieves symptoms related to blood stasis.

[0015] Prunella Vulgaris, effects: clearing away heat and purging fire, improving eyesight, dispersing stagnation and reducing swelling; function: used for symptoms such as red and swollen eyes, headache and dizziness, scrofula and goiter, etc., by clearing away heat and dispersing stagnation to eliminate lumps formed by accumulation of heat and toxins.

[0016] Brown sugar, efficacy: tonifies the middle and relieves urgency, promotes blood circulation and removes blood stasis, soothes the stomach and relieves pain; function: harmonizes the medicinal properties, relieves the stimulation of bitter and cold drugs on the spleen and stomach, and at the same time enhances the effect of promoting blood circulation and removing blood stasis, and assists in the treatment of blood stasis syndrome.

[0017] Rehmannia root extract, efficacy: nourishes yin and replenishes blood, replenishes essence and fills marrow; effects: targets liver and kidney yin deficiency, soreness of waist and knees, bone steaming and hot flashes, etc., improves yin deficiency symptoms by nourishing yin and tonifying the kidney, and enhances the body's disease resistance.

[0018] Cornus officinalis extract, efficacy: nourishes the liver and kidneys, astringes essence and prevents loss of essence; function: used for symptoms such as dizziness, tinnitus, pain in the waist and knees, impotence and spermatorrhea, by nourishing the liver and kidneys to consolidate essence and prevent leakage of essence.

[0019] Chinese yam extract, efficacy: nourishes the spleen and stomach, promotes fluid production and benefits the lungs, nourishes the kidneys and astringes essence; effects: targets symptoms such as spleen deficiency, poor appetite, fatigue, loose stools and diarrhea, by nourishing the spleen and kidneys, strengthening the spleen and stomach's transportation and transformation functions and improving digestion and absorption.

[0020] Poria extract: Benefits: Diuresis and Dampness, Strengthening the Spleen and Calming the Heart; Uses: Treats spleen deficiency, diarrhea, restlessness, palpitations, insomnia, etc. It promotes water metabolism by strengthening the spleen and removing dampness, relieving edema and symptoms of spleen deficiency. The above-mentioned Chinese medicinal raw materials are made into a Chinese medicinal health-care drink, which has the core functions of nourishing yin and tonifying the kidney, promoting blood circulation and regulating menstruation, clearing away heat and dispersing stagnation. It is suitable for various diseases caused by liver and kidney yin deficiency, blood stasis or accumulation of heat and toxicity, such as soreness of the waist and knees, irregular menstruation, scrofula and goiter, etc. Brown sugar is added to the health-care drink, which can neutralize the bitterness of some medicinal materials such as Prunella vulgaris and Rehmannia glutinosa, making the overall taste of the drink more balanced, and it is more easily accepted by people than the taste of pills.

[0021] Compared with the prior art, the present invention can achieve the following technical effects: 1. The present invention mixes Chinese angelica, herb Prunella vulgaris, and brown sugar with extracts of Rehmannia root, Cornus officinalis, Chinese yam, and Poria cocos. The efficacy exhibits the characteristics of multi-target synergistic enhancement, and the overall effect is more comprehensive and complementary. Rehmannia root, Cornus officinalis, and Chinese yam jointly strengthen kidney yin, improving symptoms of yin deficiency such as soreness of the waist and knees, dizziness, and tinnitus. Chinese angelica promotes blood circulation and regulates menstruation, while herb Prunella vulgaris clears heat and disperses stagnation. The two form a "clearing-clearing" combination for blood stasis or accumulation of heat and toxins (such as breast nodules and thyroid nodules), relieving local swelling or pain. Yin deficiency constitution is often accompanied by blood stasis or heat and toxins. This formula combines nourishing yin and blood (treating the root cause) with promoting blood circulation and dispersing stagnation (treating the symptoms), treating both the symptoms and the root cause. Poria cocos strengthens the spleen and prevents endogenous dampness and turbidity, while brown sugar protects the stomach and aids in drug absorption. The two together improve the tolerability and durability of the overall formula.

[0022] 2. In the preparation process of the present invention, wrapping and soaking the angelica and Prunella vulgaris before extraction can effectively promote the dissolution of the active ingredients and reduce the heating time and energy consumption in the subsequent extraction process. Experiments have shown that to achieve similar extraction effects, the extraction time can be shortened by 80% using the soaking-extraction process of the present invention.

[0023] 3. During preparation, the present invention injects the constant volume liquid into a high-pressure homogenizer and then performs two high-pressure homogenizations, which can ensure that the particles in the mixed liquid are more evenly distributed and avoid agglomeration, thereby improving the physical stability of the overall preparation, reducing stratification or precipitation, and extending the shelf life. DETAILED DESCRIPTION

[0024] The following examples are given to illustrate the specific embodiments of the present invention in more detail, but the present invention is certainly not limited to these embodiments. Example 1

[0025] A formula for a traditional Chinese medicine drink, Liuwei Dihuang Drink, is composed of the following raw materials in the following weight percentages: 0.15% angelica sinensis, 0.15% selfheal, 4% brown sugar, 0.06% rehmannia root extract, 0.06% cornus officinalis extract, 0.06% yam extract, 0.06% poria extract, and the balance water. The rehmannia root extract, cornus officinalis extract, yam extract, and poria extract in this embodiment are all in powder form, and the particle size is 95% passing through an 80-mesh sieve.

[0026] The preparation method of Liuwei Dihuang Decoction in this embodiment comprises the following steps: 1) Wrapping angelica and prunella vulgaris and soaking them in purified water at 100°C for 20 minutes, then placing the soaked angelica and prunella vulgaris bags in a mixing tank for heating extraction at 100°C for 60 minutes, removing the angelica and prunella vulgaris residue after the extraction to obtain an angelica and prunella vulgaris extract; the angelica and prunella vulgaris extract having a soluble solids content of 0.5%, a density of 0.998, and a pH of 5.8; 2) Add Rehmannia root extract, Cornus officinalis extract, Chinese yam extract, Poria cocos extract, and brown sugar in proportion to the mixing tank, stir for 12 minutes, filter through a 150-mesh filter, and transfer the filtrate to a temporary storage tank. Add 80°C purified water to continuously rinse the residual liquid in the mixing tank and pipeline until the temporary storage tank is filled to 5000L and stir for 25 minutes. At this time, the soluble solids content in the fixed volume solution should be 3.5%, the density should be 1.008, and the pH value should be 5.6. 3) The constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for two homogenizations. The homogenization pressure of the first high-pressure homogenizer is set to 32 MPa, and the homogenization pressure of the second high-pressure homogenizer is set to 48 MPa. After homogenization, the homogenized liquid is pumped into a 3-ton temporary storage tank. The soluble solids content of the homogenized liquid is 3.5%, the density is 1.008, and the pH value should be 5.6; 4) After the printed cans are cleaned inside and out with purified water, they are transported to the filling machine via a conveyor belt. The filling port of the filling machine is adjusted to the 242.4g mass scale. The filling volume must not be less than 233.4g before filling. 5) Place the filled finished product into the autoclave, set the sterilization temperature to 124°C, and the sterilization time to 19 minutes. Cool it after sterilization and take a sample after sterilization. The soluble solids content of the sterilized sample should be 3.5%, the density should be 1.009, and the pH value should be 5.4. Example 2

[0027] A formula for a traditional Chinese medicine drink, Liuwei Dihuang Drink, is composed of the following raw materials in percentage by weight: 0.1% angelica sinensis, 0.1% selfheal, 2% brown sugar, 0.01% rehmannia root extract, 0.01% cornus officinalis extract, 0.01% yam extract, 0.01% poria extract, and the balance water.

[0028] The Rehmannia root extract, Cornus officinalis extract, Chinese yam extract and Poria cocos extract are all in powder form, and 95% of the particle size passes through an 80-mesh sieve.

[0029] The preparation method of Liuwei Dihuang Decoction in this embodiment comprises the following steps: 1) Wrapping angelica and prunella vulgaris and soaking them in 80°C purified water for 20 minutes, then placing the soaked angelica and prunella vulgaris bags in a mixing tank for heating extraction at 90°C for 80 minutes, removing the angelica and prunella vulgaris residue after the extraction, thereby obtaining an angelica and prunella vulgaris extract; the angelica and prunella vulgaris extract having a soluble solids content of 0.2%, a density of 0.996, and a pH of 5.6; 2) Add Rehmannia root extract, Cornus officinalis extract, Chinese yam extract, Poria cocos extract, and brown sugar in proportion to the mixing tank, stir for 10 minutes, filter through a 150-mesh filter, and transfer the filtrate to a temporary storage tank. Add 70°C purified water to continuously rinse the residual liquid in the mixing tank and pipeline until the temporary storage tank is fixed to 5000L and stir for 20 minutes. At this time, the soluble solids content in the fixed volume solution should be 3.2%, the density should be 1.006, and the pH value should be 5.2; 3) The constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for two homogenizations. The homogenization pressure of the first high-pressure homogenizer is set to 30 MPa, and the homogenization pressure of the second high-pressure homogenizer is set to 45 MPa. After homogenization, the homogenized liquid is pumped into a 3-ton temporary storage tank. The soluble solids content of the homogenized liquid is 3.2%, the density is 1.006, and the pH value should be 5.2; 4) After the printed cans are cleaned inside and out with purified water, they are transported to the filling machine via a conveyor belt. The filling port of the filling machine is adjusted to the 242.4g mass scale. The filling volume must not be less than 233.4g before filling. 5) Place the filled finished product into the autoclave, set the sterilization temperature to 121°C, and the sterilization time to 20 minutes. Cool it after sterilization and take a sample after sterilization. The soluble solids content of the sterilized sample should be 3.2%, the density should be 1.008, and the pH value should be 5.1. Example 3

[0030] A formula for a traditional Chinese medicine drink, Liuwei Dihuang Yin, is composed of the following raw materials in percentage by weight: 0.2% angelica sinensis, 0.2% selfheal, 6% brown sugar, 0.08% rehmannia root extract, 0.08% cornus officinalis extract, 0.08% yam extract, 0.08% poria extract, and the balance water.

[0031] The Rehmannia root extract, Cornus officinalis extract, Chinese yam extract and Poria cocos extract are all in powder form, and 95% of the particle size passes through an 80-mesh sieve.

[0032] The preparation method of Liuwei Dihuang Decoction in this embodiment comprises the following steps: 1) Wrapping angelica and prunella vulgaris and soaking them in purified water at 100°C for 30 minutes, then placing the soaked angelica and prunella vulgaris bags in a mixing tank for heating extraction at 100°C for 60 minutes, removing the angelica and prunella vulgaris residue after the extraction, thereby obtaining an angelica and prunella vulgaris extract; the angelica and prunella vulgaris extract having a soluble solids content of 0.6%, a density of 1.000, and a pH of 6.2; 2) Add Rehmannia root extract, Cornus officinalis extract, Chinese yam extract, Poria cocos extract, and brown sugar in proportion to the mixing tank, stir for 15 minutes, filter through a 150-mesh filter, and transfer the filtrate to a temporary storage tank. Add 85°C purified water to continuously rinse the residual liquid in the mixing tank and pipeline until the temporary storage tank is filled to 5000L and stir for 30 minutes. At this time, the soluble solids content in the fixed volume solution should be 3.7%, the density should be 1.012, and the pH value should be 5.8. 3) The constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for two homogenizations. The homogenization pressure of the first high-pressure homogenizer is set to 32 MPa, and the homogenization pressure of the second high-pressure homogenizer is set to 48 MPa. After homogenization, the homogenized liquid is pumped into a 3-ton temporary storage tank. The soluble solids content of the homogenized liquid is 3.7%, the density is 1.012, and the pH value should be 5.8; 4) After the printed cans are cleaned inside and out with purified water, they are transported to the filling machine via a conveyor belt. The filling port of the filling machine is adjusted to the 242.4g mass scale. The filling volume must not be less than 233.4g before filling. 5) Place the filled finished product into an autoclave, set the sterilization temperature to 125°C, and the sterilization time to 20 minutes. Cool it after sterilization and take a sample after sterilization. The soluble solids content of the sterilized sample should be 3.7%, the density should be 1.012, and the pH value should be 5.6.

[0033] Comparative Example 1 This comparative example is the same as Example 1, except that, in step 3), the constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for one homogenization, and the homogenization pressure is set to 32 MPa.

[0034] Comparative Example 2 This comparative example is the same as Example 1, except that, in step 3), the constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for one homogenization, and the homogenization pressure is set to 48 MPa.

[0035] Stability tests were conducted on the medium drinks obtained in Examples 1, 2, 3 and Comparative Examples 1 and 2. Each group of samples was placed in a stability test chamber and the precipitation was observed after 0, 1, 2, and 3 months. The results are shown in Table 1 below.

[0036] Judging from the test results, no precipitation occurred in one month regardless of whether the homogenization was performed in one step or two steps. When the experiment was carried out for two months, a small amount of precipitation began to appear in the medium drink when one step was used for homogenization. However, no precipitation occurred in the present invention after three months, indicating that the medium drink obtained by the two-step high-pressure homogenization of the present invention has better stability.

[0037] The above embodiments are merely illustrative of the detailed methods of the present invention, but the present invention is not limited to the above detailed methods, nor does it mean that the present invention must rely on the above detailed methods in order to be implemented. Those skilled in the art will appreciate that any improvements to the present invention, equivalent replacements of raw materials for the products of the present invention, addition of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present invention.

Claims

1. A formula of Liuwei Dihuang Drink, characterized in that: The raw materials are composed according to the following weight percentages: 0.1-0.2% of angelica sinensis, 0.1-0.2% of selfheal, 2-6% of brown sugar, 0.01-0.08% of rehmannia root extract, 0.01-0.08% of cornus officinalis extract, 0.01-0.08% of yam extract, 0.01-0.08% of poria extract and the balance of water.

2. The Chinese medicine Liuwei Dihuang Drink formula according to claim 1, characterized in that: The Rehmannia root extract, Cornus officinalis extract, Chinese yam extract and Poria cocos extract are all in powder form, and 95% of the particle size passes through an 80-mesh sieve.

3. The preparation method of the Chinese medicine Liuwei Dihuang Decoction according to claim 1, characterized in that: The following steps are involved: 1) Wrapping the angelica and prunella vulgaris and soaking them in purified water at 80-100°C for 20-30 minutes, then heating the soaked angelica and prunella vulgaris in a mixing tank for extraction at 90-100°C for 60-80 minutes. After the extraction is complete, remove the angelica and prunella vulgaris residue to obtain the angelica and prunella vulgaris extract. 2) Add Rehmannia root extract, Cornus officinalis extract, Chinese yam extract, Poria cocos extract, and brown sugar in proportion to the mixing tank, stir for 10-15 minutes, filter through a 150-mesh filter, and let the filtrate enter a temporary storage tank. Add 70-85℃ purified water to continuously rinse the residual liquid in the mixing tank and pipeline until the temporary storage tank is fixed to 5000L, and stir for 20-30 minutes to obtain the fixed volume solution; 3) The constant volume liquid in the temporary storage tank is pumped into a high-pressure homogenizer for two homogenizations. The homogenization pressure of the first high-pressure homogenizer is set to 30-35Mpa, and the homogenization pressure of the second high-pressure homogenizer is set to 45-50Mpa. After homogenization, the homogenized liquid is pumped into a 3-ton temporary storage tank; 4) After the printed cans are cleaned inside and out with purified water, they are transported to the filling machine via a conveyor belt. The filling port of the filling machine is adjusted to the 242.4g mass scale. The filling volume must not be less than 233.4g before filling. 5) Place the filled finished product into the autoclave, set the sterilization temperature to 121-125℃, and the sterilization time to 18-20min. After sterilization, cool it down.

4. The preparation method of the Chinese medicine Liuwei Dihuang Decoction according to claim 3, characterized in that: In step 1), the soluble solids content of the angelica and prunella vulgaris extract should be 0.2% to 0.6%, the density should be 0.996 to 1.000, and the pH value should be 5.6 to 6.

2.

5. The preparation method of the Chinese medicine Liuwei Dihuang Decoction according to claim 3, characterized in that: In step 2), the soluble solids content of the volume-fixing solution should be 3.2% to 3.7%, the density should be 1.006 to 1.012, and the pH value should be 5.2 to 5.

8.

6. The preparation method of the Chinese medicine Liuwei Dihuang Decoction according to claim 3, characterized in that: In step 3), the homogenized liquid has a soluble solid content of 3.2% to 3.7%, a density of 1.006 to 1.012, and a pH of 5.2 to 5.

8.

7. The preparation method of the Chinese medicine Liuwei Dihuang Decoction according to claim 3, characterized in that: In step 5), the soluble solids content of the sterilized sample should be 3.2%~3.7%, the density should be 1.008~1.012, and the pH value should be 5.1~5.5.

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