Traditional Chinese medicine composition for warming and activating meridians, dispelling wind and dredging arthralgia and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for warming and activating meridians, dispelling wind and dredging arthralgia and a preparation method thereof, the traditional Chinese medicine composition is prepared from the following raw materials: astragalus membranaceus, cassia twig, radix paeoniae alba, angelica sinensis, notopterygium root, radix angelicae pubescentis, divaricate saposhnikovia root, rhizoma wenyujin concisum, radix cyathulae, mistletoe, earthworm, honey-fried licorice root and vinegar frankincense. Astragalus mongholicus is sweet and warm, can tonify primordial qi, invigorate qi and blood, and can promote blood circulation and remove blood stasis to dredge collaterals, angelica sinensis can enrich blood and activate blood, angelica sinensis and astragalus mongholicus are used together to tonify qi and activate blood, eliminate arthralgia and dredge collaterals, and are used as monarch drugs; cassia twig, turmeric, radix paeoniae alba and radix cyathulae are used as ministerial drugs for promoting qi to activate blood, warming channels and relieving pain; mistletoe, notopterygium root, radix angelicae pubescentis and divaricate saposhnikovia root are added to dispel cold-dampness, tonify liver and kidney and strengthen tendons and bones; the vinegar frankincense and the earthworm have the effects of clearing and activating the channels and collaterals, and guiding all the medicines to directly reach the collaterals, and the liquorice relieves spasm and pain, harmonizes all the medicines and co-assistants; the medicines are combined for use to achieve the effects of warming meridians, activating collaterals, dispelling wind and dredging arthralgia, and various symptoms can be cured.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for warming the meridians and unblocking the collaterals, dispelling wind and relieving numbness, and a preparation method thereof. Background Art

[0002] Low back pain, also known as "lumbar pain," is a common clinical condition. It's often caused by the six exogenous pathogenic factors, strain, sprains, or kidney deficiency, which can lead to poor circulation of Qi and blood. This leads to poor nourishment of the lower back and tight tendons, resulting in paravertebral, interspinous, and supraspinal pain. Cold-dampness-induced stagnation is particularly common. Cold, a Yin pathogen, contracts and closes the body, invading the skin and meridians, and obstructing Wei Yang, causing poor Qi and blood circulation in the lower back.

[0003] Rheumatoid arthritis is a chronic, inflammatory, systemic autoimmune disease. Its fundamental pathological changes are synovitis, characterized by swelling, exudation, and neutrophil infiltration in the acute phase, and hyperplasia and thickening of the synovium in the chronic phase, with the formation of pannus. The latter is the pathological basis for joint destruction, deformity, and dysfunction, leading to the irreversible stage of the disease. Synovial inflammation and exudation, along with fibrotic degeneration of cartilage, are the primary processes that lead to joint swelling, stiffness, and deformation in human rheumatoid arthritis patients.

[0004] Traditional Chinese medicine categorizes rheumatoid arthritis into six types: dampness-induced exterior syndrome, mixed cold and heat syndrome, cold-damp stagnation syndrome, cold-coagulation and blood stasis syndrome, qi and blood deficiency syndrome with phlegm and stasis, and liver and kidney deficiency. Symptoms of rheumatoid arthritis in the cold-damp stagnation syndrome include cold, heavy, and painful joints and muscles, with localized pain, significant morning stiffness, severe joint pain, or even inability to flex or extend joints, increased pain with cold and reduced with warmth, a pale, puffy tongue with a white or greasy coating, and a wiry or deep pulse.

[0005] Currently, there are numerous medications and treatment options for rheumatoid arthritis. The emergence of biologics, in particular, has greatly improved clinical efficacy. However, these treatments also present challenges, such as high costs and various side effects and adverse reactions. Traditional Chinese Medicine (TCM) adheres to the principle of syndrome differentiation and treatment, formulating medications tailored to specific symptom types, offering significant advantages over Western medicine in both efficacy and cost-effectiveness. Therefore, it is crucial to identify safe and effective TCM formulas that warm the meridians, dredge the collaterals, and dispel wind and relieve numbness for the treatment of low back pain and rheumatoid arthritis. Summary of the Invention

[0006] The present invention aims to address the deficiencies of the prior art by providing a traditional Chinese medicine composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness, as well as its preparation method and use. The composition significantly reduces the pain behavioral score of low back pain caused by cold-dampness stagnation, demonstrating a therapeutic effect on low back pain caused by cold-dampness stagnation and also has a positive therapeutic effect on rheumatoid arthritis.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] The first aspect of the present invention provides a traditional Chinese medicine composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness, wherein the traditional Chinese medicine composition is prepared from astragalus, cinnamon twig, white peony root, angelica, notopterygium root, angelica pubescens, saposhnikovia root, turmeric, cyathula, mistletoe, earthworm, roasted liquorice root and vinegar frankincense.

[0009] In some preferred embodiments of the present invention, the traditional Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness is made from the following raw materials in parts by weight: 25-35 parts of astragalus, 6-12 parts of cinnamon twig, 6-12 parts of white peony root, 6-12 parts of angelica, 6-12 parts of notopterygium, 6-12 parts of angelica root, 6-12 parts of notopterygium, 6-12 parts of siler, 6-12 parts of turmeric, 6-12 parts of cyathula, 6-12 parts of mistletoe, 4-8 parts of earthworm, 4-8 parts of roasted liquorice and 4-8 parts of vinegar frankincense.

[0010] In a preferred embodiment of the present invention, the traditional Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness is made from the following raw materials in parts by weight: 30 parts of astragalus, 9 parts of cinnamon twig, 9 parts of white peony root, 9 parts of angelica, 9 parts of notopterygium, 9 parts of angelica root, 9 parts of angelica root, 9 parts of saposhnikovia root, 9 parts of turmeric, 9 parts of cyathula, 9 parts of mistletoe, 6 parts of earthworm, 6 parts of roasted licorice and 6 parts of vinegar frankincense.

[0011] In a preferred embodiment of the present invention, the traditional Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness is made from the following raw materials in parts by weight: 25 parts of astragalus, 12 parts of cinnamon twig, 12 parts of white peony root, 6 parts of angelica, 6 parts of notopterygium, 12 parts of angelica pubescens, 12 parts of saposhnikovia divaricata, 6 parts of turmeric, 12 parts of cyathula, 6 parts of mistletoe, 8 parts of earthworm, 8 parts of roasted liquorice and 4 parts of vinegar frankincense.

[0012] In a preferred embodiment of the present invention, the traditional Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness is made from the following raw materials in parts by weight: 35 parts of astragalus, 6 parts of cinnamon twig, 6 parts of white peony root, 12 parts of angelica, 12 parts of notopterygium, 6 parts of angelica pubescens, 6 parts of saposhnikovia divaricata, 12 parts of turmeric, 12 parts of cyathula, 12 parts of mistletoe, 4 parts of earthworm, 4 parts of roasted licorice and 8 parts of vinegar frankincense.

[0013] The Chinese medicine composition of the present invention further comprises pharmaceutically acceptable excipients, including but not limited to solvents, solubilizers, cosolvents, colorants, disintegrants, fillers, lubricants, wetting agents, stabilizers, flavoring agents, preservatives, suspending agents, coating materials, anti-adhesive agents, integrities, plasticizers, etc. The dosage form of the Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or ointments.

[0014] Furthermore, the dosage form of the Chinese medicine composition for warming the meridians, dredging the collaterals, dispelling wind and relieving numbness is granules.

[0015] The second aspect of the present invention provides a preparation method of the traditional Chinese medicine composition for warming the meridians, dredge the collaterals, dispel wind and relieve numbness, which is specifically as follows: weigh the medicinal materials by weight, add water and boil twice, the first time adding water in an amount of 6-8 times the weight of the medicinal materials, boiling for 1-2 hours, and the second time adding water in an amount of 6-8 times the weight of the medicinal materials, boiling for 1-2 hours, and combining the decoctions.

[0016] Furthermore, the preparation method of the present invention is as follows: weigh the medicinal materials by weight, add water and boil twice, the first time adding water is 8 times the weight of the medicinal materials, boiling for 2 hours, the second time adding water is 6 times the weight of the medicinal materials, boiling for 1 hour, and combining the decoctions.

[0017] The third aspect of the present invention provides use of the Chinese medicinal composition for warming the meridians and dredging the collaterals, dispelling wind and relieving numbness in the preparation of a medicine for preventing or treating low back pain.

[0018] In a preferred embodiment of the present invention, the low back pain is low back pain caused by cold and dampness.

[0019] The fourth aspect of the present invention provides use of the traditional Chinese medicine composition for warming the meridians, dredging the collaterals, dispelling wind and relieving numbness in the preparation of a drug for preventing or treating rheumatoid arthritis.

[0020] Compared with the prior art, the present invention has the following beneficial effects:

[0021] In the prescription of the present invention, astragalus root is sweet and warm and can greatly invigorate vital energy and replenish qi and blood, so that qi is strong and blood circulates, blood stasis is removed and collaterals are unblocked; angelica root replenishes blood and activates blood circulation, and angelica root and astragalus root are used together to invigorate qi and activate blood circulation, relieve numbness and dredge collaterals, and are the main medicines; cinnamon twig, turmeric, white peony root and rhizome of Sichuan cyperus are used as assistant medicines to promote qi, activate blood circulation, warm the meridians and relieve pain; mistletoe, notopterygium root, angelica root and saposhnikovia root are added as auxiliary medicines to dispel cold and dampness, invigorate the liver and kidneys, and strengthen the tendons and bones; vinegar frankincense and earthworm can dredge the meridians and activate the collaterals, and have special effects on the circulation, leading all the medicines to directly reach the collaterals; liquorice relieves urgency and stops pain, harmonizes all the medicines, and are used as auxiliary medicines; all the medicines are used together to warm the meridians, activate the collaterals, dispel wind and relieve numbness, and various symptoms can be cured.

[0022] SP is an important neuropeptide that plays a crucial role in the pathogenesis of inflammation and pain. The Chinese medicinal composition of the present invention reduced paw swelling and lowered SP levels in plasma and synovium in rats with adjuvant arthritis, suggesting that the Chinese medicinal composition of the present invention has significant anti-inflammatory and analgesic effects in rats with adjuvant arthritis.

[0023] The traditional Chinese medicine composition of the present invention significantly reduces the pain behavior score of the cold-dampness stagnation type low back pain model and has a therapeutic effect on the cold-dampness stagnation type low back pain.

[0024] The Chinese medicine composition of the present invention has significant effects, provides a medicine for clinical treatment of cold-dampness stagnation type low back pain that is easy to use, has significant effects, and has no toxic side effects, and has high practical value. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1The paw swelling of rats in each group was compared. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0026] Figure 2 Comparison of plasma SP levels in rats of each group. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05).

[0027] Figure 3 Comparison of SP content in the synovium of rats in each group. Different lowercase letters above the bar graph indicate significant differences among different groups (P<0.05). DETAILED DESCRIPTION

[0028] The embodiments of the present invention will be described in detail below with reference to examples. However, those skilled in the art will understand that the following examples are only used to illustrate the present invention and should not be construed as limiting the scope of the present invention.

[0029] Example 1

[0030] Astragalus 30g, cinnamon twig 9g, white peony root 9g, angelica 9g, notopterygium root 9g, duhuo 9g, siler 9g, turmeric 9g, chuanxiong 9g, mistletoe 9g, earthworm 6g, roasted liquorice root 6g, and vinegar frankincense 6g.

[0031] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water 8 times the weight of the medicinal materials and boil for 2 hours. The second time, add water 6 times the weight of the medicinal materials and boil for 1 hour. Combine the decoctions.

[0032] Example 2

[0033] Astragalus 25g, cinnamon twig 12g, white peony root 12g, angelica 6g, notopterygium root 6g, duhuo 12g, siler 12g, turmeric 6g, chuanxiong 12g, mistletoe 6g, earthworm 8g, roasted liquorice root 8g, and vinegar frankincense 4g.

[0034] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water 7 times the weight of the medicinal materials and boil for 1.5 hours. The second time, add water 8 times the weight of the medicinal materials and boil for 1 hour. Combine the decoctions.

[0035] Example 3

[0036] Astragalus 35g, cinnamon twig 6g, white peony root 6g, angelica 12g, notopterygium root 12g, duhuo 6g, siler 6g, turmeric 12g, cyperus rotundus 12g, mistletoe 12g, earthworm 4g, roasted liquorice root 4g and vinegar frankincense 8g.

[0037] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water 6 times the weight of the medicinal materials and boil for 1 hour. The second time, add water 8 times the weight of the medicinal materials and boil for 1.5 hours. Combine the decoctions.

[0038] Example 4

[0039] Astragalus 25g, cinnamon twig 10g, white peony root 12g, angelica 10g, notopterygium root 8g, duhuo 9g, siler 6g, turmeric 12g, cyperus rotundus 10g, mistletoe 6g, earthworm 6g, roasted liquorice root 4g and vinegar frankincense 8g.

[0040] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water 6 times the weight of the medicinal materials and boil for 1 hour. The second time, add water 6 times the weight of the medicinal materials and boil for 1.5 hours. Combine the decoctions.

[0041] Example 5

[0042] Astragalus 35g, cinnamon twig 12g, white peony root 6g, angelica 12g, notopterygium root 6g, duhuo 6g, siler 12g, turmeric 9g, cyperus 9g, mistletoe 10g, earthworm 8g, roasted liquorice root 6g, and vinegar frankincense 4g.

[0043] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water in an amount of 8 times the weight of the medicinal materials and boil for 2 hours. The second time, add water in an amount of 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions.

[0044] Example 6

[0045] Astragalus 30g, cinnamon twig 9g, white peony root 12g, angelica 6g, notopterygium root 9g, duhuo 10g, siler 9g, turmeric 10g, cyperus rotundus 12g, mistletoe 6g, earthworm 6g, roasted liquorice root 4g, and vinegar frankincense 4g.

[0046] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water 6 times the weight of the medicinal materials and boil for 1.5 hours. The second time, add water 6 times the weight of the medicinal materials and boil for 1.5 hours. Combine the decoctions.

[0047] Example 7

[0048] Astragalus 30g, cinnamon twig 6g, white peony root 9g, angelica 9g, notopterygium root 6g, duhuo 12g, siler 6g, turmeric 9g, cyperus rotundus 10g, mistletoe 12g, earthworm 4g, roasted liquorice root 8g, and vinegar frankincense 6g.

[0049] Preparation method: Weigh the medicinal materials by weight, add water and boil twice. The first time, add water in an amount of 8 times the weight of the medicinal materials and boil for 2 hours. The second time, add water in an amount of 6 times the weight of the medicinal materials and boil for 2 hours. Combine the decoctions.

[0050] Comparative Example 1

[0051] 9g of cinnamon twig, 9g of white peony root, 9g of notopterygium root, 9g of angelica root, 9g of saposhnikovia root, 9g of turmeric, 9g of Sichuan cyathula, 9g of mistletoe, 6g of earthworm, 6g of roasted liquorice root and 6g of vinegar and frankincense.

[0052] Compared with Example 1, the invention does not contain astragalus and angelica, and other ingredients and contents remain unchanged.

[0053] Comparative Example 2

[0054] Astragalus 30g, White Peony 9g, Chinese Angelica 9g, Notopterygium 9g, Duhuo 9g, Saposhnikovia 9g, Cyathula 9g, Mistletoe 9g, Earthworm 6g, Roasted Licorice 6g, and Vinegar and Frankincense 6g.

[0055] Compared with Example 1, the invention does not contain cassia twig and turmeric, and other ingredients and contents remain unchanged.

[0056] Comparative Example 3

[0057] Astragalus 30g, cinnamon twig 9g, angelica 9g, notopterygium root 9g, duhuo 9g, siler 9g, fangfeng 9g, turmeric 9g, mistletoe 9g, earthworm 6g, roasted liquorice 6g and vinegar frankincense 6g.

[0058] Compared with Example 1, the invention does not contain white peony root and Sichuan cyathula, and other components and contents remain unchanged.

[0059] Comparative Example 4

[0060] Astragalus 30g, cinnamon twig 9g, white peony root 9g, angelica 9g, Duhuo 9g, Saposhnikovia 9g, turmeric 9g, Sichuan cyperus 9g, earthworm 6g, roasted liquorice 6g and vinegar frankincense 6g.

[0061] Compared with Example 1, the invention does not contain Notopterygium wilfordii and Viscum album, and other ingredients and contents remain unchanged.

[0062] Comparative Example 5

[0063] Astragalus 30g, cinnamon twig 9g, white peony root 9g, angelica 9g, notopterygium root 9g, duhuo 9g, siler 9g, turmeric 9g, chuanxiong 9g, mistletoe 9g and roasted liquorice root 6g.

[0064] Compared with Example 1, the invention does not contain vinegar frankincense and earthworm, and other ingredients and contents remain unchanged.

[0065] The preparation methods of the Chinese medicine compositions of Comparative Examples 1-5 refer to Example 1.

[0066] Efficacy Example 1 Therapeutic effect of the Chinese medicine composition of the present invention on rats with low back pain caused by cold-dampness stagnation

[0067] 1. Experimental Methods

[0068] Fifty-four SPF male SD rats, weighing 160-200 g, were housed in a room maintained at 20-25°C with free access to water and food. After 7 days of quarantine, six rats were randomly selected as a blank control group, and the remaining rats were used for modeling.

[0069] Except for the blank control group, the abdomens of all rats were disinfected alternately with iodine-containing disinfectant and 75% ethanol. Under sterile conditions, anesthesia was achieved by intraperitoneal injection of 30 mg / kg of sodium pentobarbital. The rats were placed in the prone position on the operating table. The back hair was trimmed and disinfected. A sterile drape was placed over the rats. The skin was incised along the midline of the back, and the subcutaneous tissue and muscle were separated layer by layer to expose the lumbar vertebrae 2-4. The supraspinal ligaments and interspinous ligaments of the lumbar vertebrae 2-4 and the upper and lower articular process joints on both sides were resected and damaged. After compression and hemostasis, the incisions were sutured layer by layer.

[0070] On the third day after surgery, penicillin was injected intramuscularly into the buttocks of rats at a dose of 20,000 U / 100 g to prevent infection.

[0071] The rats in the blank control group were kept in standard environment cages, and the model rats were kept in a simulated cold and humid environment cage for 6 hours a day, at a temperature of 4-6°C and an air relative humidity of 60%-75%, for 6 consecutive weeks.

[0072] After modeling, the rats showed clinical characteristics of cold-dampness syndrome, such as fear of cold and preference for warmth, less physical activity, limb fatigue, and loose stools.

[0073] The modeled rats were randomly divided into model control group, Example 1 group, Example 2 group, Comparative Example 1 group, Comparative Example 2 group, Comparative Example 3 group, Comparative Example 4 group, and Comparative Example 5 group, with 6 rats in each group.

[0074] Two weeks after modeling, Example 1-2 groups and Comparative Example 1-5 groups were gavaged with the corresponding composition at a dose of 16.6 g / kg, and the blank control group and model control group were gavaged with an equal volume of normal saline, once a day for 3 consecutive weeks.

[0075] 2. Index detection

[0076] Spontaneous pain behavior scores were evaluated in rats of each group 2 weeks after model establishment and 3 weeks after drug administration.

[0077] The scoring criteria are as follows:

[0078] 0 points, normal motor behavior and no deformity of the hind paws;

[0079] 1 point, basically normal motor behavior, obvious deformity of the hind paw, licking and biting of the limbs ≤ 2 times;

[0080] 2 points, mild abnormality in motor behavior, with lameness and foot drop, 2 times≤ licking and biting of limbs≤4 times;

[0081] 3 points: severely abnormal motor behavior, atrophy of the hind paws, licking phenomenon, licking and biting of the limbs ≥ 5 times.

[0082] 3. Statistical methods

[0083] Graphpad Prism 7.0 software was used for data processing and the measurement data were The comparison among multiple groups was performed by one-way analysis of variance, and the comparison between groups was performed by SNK-q. The difference was considered statistically significant when P < 0.05.

[0084] 4. Experimental Results

[0085] Table 1 Comparison of spontaneous pain behavior scores ( n=6, points)

[0086]

[0087] Note: *Compared with the blank control group, P < 0.05; **Compared with the blank control group, P < 0.01;

[0088] #Compared with the model control group, P<0.05; ##Compared with the model control group, P<0.01.

[0089] Two weeks after modeling and three weeks after administration, the spontaneous pain behavioral scores of rats in the model control group increased compared with the blank control group. Compared with the model control group, the spontaneous pain behavioral scores of rats in Example 1 and Example 2 were significantly reduced. The effect of reducing the spontaneous pain behavioral scores in Example 1 was the best, and was significantly better than those in Comparative Examples 1-5. The results are shown in Table 1.

[0090] The above-mentioned efficacy examples achieve the purpose of destroying the mechanical stability of the spine, reducing the strength of the rat's back muscles and the influence of cold and dampness on the cause of the disease through the experimental method of partial resection of the posterior column structure of the lumbar vertebra + cold and damp environment feeding, and construct an animal model of cold and dampness blocking type low back pain in rats. The Chinese medicine composition of the present invention significantly reduces the pain behavior score and has a therapeutic effect on cold and dampness blocking type low back pain.

[0091] Efficacy Example 2 Therapeutic Effect of the Chinese Medicine Composition of the Present Invention on Adjuvant Arthritis Rats

[0092] 1. Experimental Methods

[0093] Fifty-four SPF male SD rats, weighing 160-200 g, were housed in a room maintained at 20-25°C with free access to water and food. After 7 days of quarantine, six rats were randomly selected as a blank control group, and the remaining rats were used for modeling.

[0094] Except for the blank control group, the other rats were intradermally injected with 0.1 ml of complete Freund's adjuvant at the plantar part of the right hind limb, and the blank control group rats were injected with 0.1 ml of normal saline. The rats after modeling were randomly divided into a model control group, an embodiment 1 group, an embodiment 3 group, a comparative example 1 group, a comparative example 2 group, a comparative example 3 group, a comparative example 4 group, and a comparative example 5 group, with 6 rats in each group. The embodiment 1, 3 groups, and comparative example 1-5 groups were gavaged with the corresponding composition at a dose of 16.6 g / kg, and the blank control group and the model control group were gavaged with an equal volume of normal saline, once per gavage day, and administered continuously for 30 days.

[0095] 2. Index detection

[0096] 2.1 Determination of foot swelling

[0097] On the 30th day after inflammation, the rats were weighed and the plantar swelling of the right hind paw of each rat was measured.

[0098] 2.2 Determination of substance P (SP) content

[0099] Blood was collected from rat veins and centrifuged to extract plasma. The synovium of rat knee joints was prepared and the supernatant was extracted. The SP content in the plasma and synovium was determined using a kit.

[0100] 3. Statistical methods

[0101] Graphpad Prism 7.0 software was used for data processing and the measurement data were The comparison among multiple groups was performed by one-way analysis of variance, and the comparison between groups was performed by SNK-q. The difference was considered statistically significant when P < 0.05.

[0102] 4. Experimental Results

[0103] 4.1 Effect on rat foot swelling

[0104] Compared with the blank control group, the paw swelling of rats in the model control group increased. Compared with the model control group, the paw swelling of Example 1 and Example 3 groups were significantly reduced. The effect of Example 1 on reducing paw swelling was the best, significantly better than that of Comparative Examples 1-5 groups. Figure 1 .

[0105] 4.2 Effects on SP content in rats

[0106] Compared with the blank control group, the SP content in the plasma and synovial membrane of the rats in the model control group increased. Compared with the model control group, the SP content in the plasma and synovial membrane of the Example 1 and Example 3 groups were significantly reduced. The effect of reducing the SP content in the plasma and synovial membrane of the Example 1 group was the best, and was significantly better than the comparative examples 1-5 groups. Figure 2 、 Figure 3 .

[0107] Freund's adjuvant arthritis is a fundamental animal model for rheumatoid arthritis. SP is an important neuropeptide that plays a crucial role in the pathogenesis of inflammation and pain. The Chinese herbal composition of the present invention reduced paw swelling and lowered SP levels in plasma and synovium in rats with adjuvant arthritis, demonstrating a significant anti-inflammatory and analgesic effect in rats with adjuvant arthritis.

[0108] While the present invention has been described in detail above using general descriptions and specific embodiments, it will be apparent to those skilled in the art that modifications and improvements may be made to the present invention. Therefore, such modifications and improvements, without departing from the spirit of the present invention, are intended to be within the scope of the present invention.

Claims

1. A Chinese medicine composition for warming the meridians and dredging the collaterals, dispelling wind and relieving numbness, characterized in that: The traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is prepared from the following raw materials in parts by weight: 25-35 parts of astragalus, 6-12 parts of cinnamon twig, 6-12 parts of white peony root, 6-12 parts of angelica, 6-12 parts of notopterygium root, 6-12 parts of pubescens, 6-12 parts of saposhnikovia root, 6-12 parts of turmeric, 6-12 parts of cyathula, 6-12 parts of mistletoe, 4-8 parts of earthworm, 4-8 parts of roasted liquorice root and 4-8 parts of vinegar frankincense.

2. The Chinese medicine composition for warming the meridians and dredging the collaterals, dispelling wind and relieving numbness according to claim 1, characterized in that: The traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is prepared from the following raw materials in parts by weight: 30 parts of astragalus, 9 parts of cinnamon twig, 9 parts of white peony root, 9 parts of angelica, 9 parts of notopterygium root, 9 parts of pubescens, 9 parts of saposhnikovia root, 9 parts of turmeric, 9 parts of cyathula, 9 parts of mistletoe, 6 parts of earthworm, 6 parts of roasted liquorice and 6 parts of vinegar frankincense.

3. The Chinese medicine composition for warming the meridians and dredging the collaterals, dispelling wind and relieving numbness according to claim 1, characterized in that: The traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is prepared from the following raw materials in parts by weight: 25 parts of astragalus, 12 parts of cinnamon twig, 12 parts of white peony root, 6 parts of angelica, 6 parts of notopterygium root, 12 parts of pubescens, 12 parts of saposhnikovia root, 6 parts of turmeric, 12 parts of cyathula, 6 parts of mistletoe, 8 parts of earthworm, 8 parts of roasted liquorice and 4 parts of vinegar frankincense.

4. The Chinese medicine composition for warming the meridians and dredging the collaterals, dispelling wind and relieving numbness according to claim 1, characterized in that The traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is prepared from the following raw materials in parts by weight: 35 parts of astragalus, 6 parts of cinnamon twig, 6 parts of white peony root, 12 parts of angelica, 12 parts of notopterygium root, 6 parts of pubescens, 6 parts of saposhnikovia root, 12 parts of turmeric, 12 parts of cyathula, 12 parts of mistletoe, 4 parts of earthworm, 4 parts of roasted liquorice and 8 parts of vinegar frankincense.

5. The Chinese medicine composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness according to any one of claims 1 to 4, characterized in that: The dosage form of the Chinese medicinal composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is decoction, granules, tablets, capsules, mixtures, syrups, pills, gels, powders or pastes.

6. The Chinese medicine composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness according to any one of claims 1 to 4, characterized in that: The preparation method of the traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is as follows: weigh the medicinal materials according to weight, add water and boil twice, the first time adding water in an amount of 6-8 times the weight of the medicinal materials, boiling for 1-2 hours, the second time adding water in an amount of 6-8 times the weight of the medicinal materials, boiling for 1-2 hours, and combining the liquids to make a decoction.

7. The Chinese medicine composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness according to any one of claims 1 to 4, characterized in that: The preparation method of the traditional Chinese medicine composition for warming the meridians, unblocking the collaterals, dispelling wind and relieving numbness is as follows: weigh the medicinal materials according to weight, add water and boil twice, the first time adding water in an amount of 8 times the weight of the medicinal materials and boiling for 2 hours, the second time adding water in an amount of 6 times the weight of the medicinal materials and boiling for 1 hour, and combining the decoctions.

8. Use of the Chinese medicinal composition for warming the meridians and dredge the collaterals, dispelling wind and relieving numbness according to any one of claims 1 to 4 in the preparation of a medicine for preventing or treating lumbago.

9. The use according to claim 8, characterized in that The low back pain is cold-dampness blocking type low back pain.

10. Use of the traditional Chinese medicine composition for warming the meridians, dredging the collaterals, dispelling wind and relieving numbness according to any one of claims 1 to 4 in the preparation of a medicament for preventing or treating rheumatoid arthritis.

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